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Items 1 to 36 of about 36
1. Smith Y, Hadway P, Ahmed S, Perry MJ, Corbishley CM, Watkin NA: Penile-preserving surgery for male distal urethral carcinoma. BJU Int; 2007 Jul;100(1):82-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile-preserving surgery for male distal urethral carcinoma.
  • OBJECTIVE: To evaluate medium-term outcome data from patients with distal urethral cancers treated with penile-preserving surgery.
  • PATIENTS AND METHODS: We analysed prospectively 18 consecutive men referred for the management of urethral carcinoma.
  • Tumours were staged according to the Tumour-Node-Metastasis classification and the patients offered penile-preserving surgery when tumours were limited to the glanular or penile urethra.
  • RESULTS: All 18 patients were suitable for penile-preserving surgery; the procedures were: three hypospadias formation with or without topical chemotherapy; four buccal mucosa urethroplasty; three glansectomy and reconstruction; six glansectomy, distal corporectomy, reconstruction and hypospadias formation; two urethrectomy with or with no excision of adjacent tunica albuginea.
  • CONCLUSION: Medium-term data show that penile-preserving surgery is a feasible treatment for men with distal urethral carcinoma, providing excellent local control without prejudicing survival; a longer follow-up is needed.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Penis / surgery. Urethral Neoplasms / surgery. Urologic Surgical Procedures, Male / standards
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Feasibility Studies. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies. Treatment Outcome

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  • (PMID = 17488307.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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2. Libby B, Chao D, Schneider BF: Non-surgical treatment of primary female urethral cancer. Rare Tumors; 2010;2(3):e55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-surgical treatment of primary female urethral cancer.
  • Primary carcinomas of the female urethra are extremely rare, with an annual incidence of less than ten in one million.
  • However, there have been several case reports demonstrating the efficacy of chemoradiation in the treatment of female urethral cancer.
  • In this report we present two cases of female primary urethral adenocarcinoma that were treated by concomitant chemotherapy and external beam radiotherapy, followed by interstitial brachytherapy.

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  • (PMID = 21139970.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994528
  • [Keywords] NOTNLM ; high-dose rate / low-dose rate. / urethral cancer
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3. Koizumi T, Bando S, Kanda K, Inai T: [Two cases of primary female urethral cancer]. Nihon Hinyokika Gakkai Zasshi; 2007 Sep;98(6):790-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Two cases of primary female urethral cancer].
  • Herein, we report two cases of female urethral cancer.
  • Magnetic resonance imaging (MRI) revealed a urethral tumor in both cases.
  • Histopathological examination of transperineal biopsy specimens from both patients suggested clear cell adenocarcinoma in case 1 and squamous cell carcinoma in case 2.
  • With reference to case 1, obturator lymph node metastases were observed during surgery, and treatment comprised combined radiotherapy to 60 Gy and chemotherapy with 5-fluorouracil and cisplatin following surgery.
  • However, metastases appeared in the lung 6 months after initial treatment and she died 20 months after surgery.
  • For case 2, tumor marker failure was observed 5 months after surgery.
  • The same combined treatment was performed and a complete response was obtained.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Urethral Neoplasms / drug therapy. Urethral Neoplasms / radiotherapy
  • [MeSH-minor] Adenocarcinoma, Clear Cell / drug therapy. Adenocarcinoma, Clear Cell / radiotherapy. Adenocarcinoma, Clear Cell / surgery. Aged. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Humans. Middle Aged. Radiotherapy Dosage. Radiotherapy, Adjuvant

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  • (PMID = 17929463.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; CF regimen
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4. Hara I, Hikosaka S, Eto H, Miyake H, Yamada Y, Soejima T, Sugimura K, Kamidono S: Successful treatment for squamous cell carcinoma of the female urethra with combined radio- and chemotherapy. Int J Urol; 2004 Aug;11(8):678-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment for squamous cell carcinoma of the female urethra with combined radio- and chemotherapy.
  • We report on two cases of women with locally advanced squamous cell carcinoma of the urethra.
  • Treatment comprised combined radiotherapy to 60 Gy and chemotherapy with 5-fluorouracil and cisplatin.
  • Patient 1 experienced recurrent inguinal lymph node metastasis on the contralateral side at 42 months after initial treatment, and the same treatment was performed followed by surgical excision.
  • Both patients remain alive with no evidence of disease, at 12 months after recurrence in Patient 1, and at 27 months after treatment in Patient 2.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Urethral Neoplasms / drug therapy. Urethral Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Antineoplastic Agents / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Therapy, Combination. Female. Fluorouracil / administration & dosage. Humans. Middle Aged

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  • (PMID = 15285764.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
  • [Number-of-references] 9
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5. Eng TY, Naguib M, Galang T, Fuller CD: Retrospective study of the treatment of urethral cancer. Am J Clin Oncol; 2003 Dec;26(6):558-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrospective study of the treatment of urethral cancer.
  • Urethral cancer is rare, encompassing less than 1% of all malignancies.
  • Therefore, it is imperative to share all available information regarding urethral cancer treatment via reportage of pertinent cases, thus enabling more complete comprehension and decision-making options by both clinicians and researchers.
  • A retrospective review of 18 consecutive patients with primary urethral cancer was performed.
  • An analysis was performed of clinical stage, treatment modality, and outcome.
  • Seven of 10 patients with low-stage diagnosis remained disease free.
  • Comparatively, only one of eight patients with high-stage cancer had no apparent disease.
  • Patients with advanced cancer treated with surgery alone had a shorter disease-free survival (23.3 months) versus those treated with combination chemo/radiation therapy (45.2 months).
  • Patients with low-stage disease exhibited increased survival with single-modality therapy.
  • However, patients with advanced cancer benefited from combined treatment using chemotherapy and radiation therapy.
  • [MeSH-major] Urethral Neoplasms / therapy

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  • (PMID = 14663371.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Karnes RJ, Breau RH, Lightner DJ: Surgery for urethral cancer. Urol Clin North Am; 2010 Aug;37(3):445-57
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery for urethral cancer.
  • Primary urethral cancers represent less than 1% of genitourinary malignancy.
  • Given this is an uncommon disease, there are limited data to guide diagnostic and treatment strategies.
  • Surgical extirpation remains the standard for most patients, with the addition of chemotherapy and radiation therapy in select patients.
  • The surgical approach to urethral cancer depends largely on the location and extent of the tumor.
  • [MeSH-major] Urethral Neoplasms / surgery

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20674699.001).
  • [ISSN] 1558-318X
  • [Journal-full-title] The Urologic clinics of North America
  • [ISO-abbreviation] Urol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Bakkali H, Benjaafar N, Mansouri A, Errihani H, Kettani F, Benchekroun A, El Gueddari Bel K: [Primary adenocarcinoma of the male urethra. A case report]. Cancer Radiother; 2002 Dec;6(6):358-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary adenocarcinoma of the male urethra. A case report].
  • [Transliterated title] L'adénocarcinome primitif de l'urètre masculin. A propos d'un cas.
  • Primary adenocarcinoma of the male urethra is very uncommon, accounts for 5% of primary urethral cancers.
  • All types of urethral carcinomas account for less than 1% of urinary malignancies in man.
  • The prognosis remains poor despite the wide surgical treatment.
  • The place of chemotherapy combined with radiotherapy must be defined by other studies.
  • We report a case of primary locally advanced adenocarcinoma arising in the bulbo-membranous urethra.
  • He was treated by combined external beam radiotherapy (total dose 67Gy) and chemotherapy (Cisplatinum).
  • A marked reduction of tumor volume has been noted but the patient died because of the appearance of bone metastasis which failed to the systemic therapy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Urethral Neoplasms / drug therapy. Urethral Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Male. Neoplasm Metastasis. Prognosis. Treatment Outcome

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  • (PMID = 12504773.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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8. Melonakos EJ, Santucci RA: Treatment of low-grade bulbar transitional cell carcinoma with urethral instillation of mitomycin C. Adv Urol; 2008;:173694

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of low-grade bulbar transitional cell carcinoma with urethral instillation of mitomycin C.
  • A 63-year old man was referred to us after three rapid recurrences of low-grade urethral papillary transitional cell carcinoma of the bulbar urethra, after repeated primary excision.
  • Cystoscopy confirmed 3-4 low-grade urethral transitional cell carcinomas, which were subsequently fulgurated.
  • After urethral healing, a solution of Mitomycin C (40 mg/80 cc) was instilled into the urethra for fifteen minutes and held in place with a penile clamp.
  • Urethral instillations were repeated weekly for six weeks.
  • This case highlights the successful treatment of urethral carcinoma with topical chemotherapy, which is usually reserved for the bladder, using a slight modification of standard technique.

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  • [Cites] BJU Int. 2006 Sep;98(3):526-31 [16925747.001]
  • [Cites] J Urol. 2000 Oct;164(4):1305 [10992392.001]
  • [Cites] J Urol. 2000 Oct;164(4):1306 [10992393.001]
  • [Cites] Urology. 1999 Jun;53(6):1126-32 [10367840.001]
  • (PMID = 18989359.001).
  • [ISSN] 1687-6369
  • [Journal-full-title] Advances in urology
  • [ISO-abbreviation] Adv Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2575232
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9. Gómez Díaz ME, Castaño González-Coto D, Cuervo Calvo J, Muruamendiaraz Fernández V: [Cancer of the female urethra. Report of a new case a review of the literature]. Arch Esp Urol; 2002 Jun;55(5):568-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cancer of the female urethra. Report of a new case a review of the literature].
  • [Transliterated title] Cáncer de uretra femenino. Aportación de un nuevo caso y revisión de la literatura.
  • OBJECTIVE: To review the main features of female urethral cancer, the only genitourinary neoplasm with a predilection for women, the ratio being 4:1.
  • Female urethral cancer is an uncommon neoplasm that accounts for only 0.02% of all cancers found in women.
  • METHODS: A case of female urethral cancer in a 52-year-old woman is presented.
  • RESULTS/CONCLUSIONS: Female urethral cancer is an uncommon neoplasm.
  • For patients with Ta-2N0M0 tumors, multimodality therapy may not be required.
  • For patients with T3-4N0M0 tumors, the best results are obtained with multimodal radiation and chemotherapy with surgical resection.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Urethral Neoplasms / pathology

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  • (PMID = 12174428.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 9
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10. Trabulsi EJ, Hoffman-Censits J: Chemotherapy for penile and urethral carcinoma. Urol Clin North Am; 2010 Aug;37(3):467-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy for penile and urethral carcinoma.
  • Although surgery is the mainstay of curative treatment of carcinomas of the penis and urethra, there is a role for systemic cytotoxic chemotherapy for locally advanced, unresectable, or metastatic tumors.
  • Although this field is limited by a paucity of clinical trials or prospective data, the available single institutional retrospective reviews indicate that multi-agent cisplatin-based combination chemotherapy regimens have significant activity and may allow curative surgery for patients with otherwise unresectable tumors.
  • This article reviews the available literature on chemotherapy for carcinoma of the penis and urethra in the neoadjuvant, adjuvant, and metastatic setting.
  • [MeSH-major] Penile Neoplasms / drug therapy. Urethral Neoplasms / drug therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Chemotherapy, Adjuvant. Humans. Male. Neoadjuvant Therapy. Taxoids / therapeutic use

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20674701.001).
  • [ISSN] 1558-318X
  • [Journal-full-title] The Urologic clinics of North America
  • [ISO-abbreviation] Urol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Taxoids
  • [Number-of-references] 34
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11. Segura Huerta A, Molina Saera J, Palomar Abad L, Pellín Ariño L, Guerrero Zotano A, Calderero Aragón V: [Advanced urethral carcinoma. Which is the best management of a infrequent disease?]. Actas Urol Esp; 2004 Jan;28(1):57-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Advanced urethral carcinoma. Which is the best management of a infrequent disease?].
  • [Transliterated title] Carcinoma uretral con extensión locorregional importante. Cómo manejamos una patología infrecuente?
  • Urethral cancer is an uncommon tumor (<0.1% of all genitourinary neoplasms).
  • Most of them are squamous carcinoma, adenocarcinomas are about 5% of all urethral cancer.
  • Surgery is the only curative treatment.
  • Chemotherapy (CT) and radiotherapy (RT) must be used in patients in which surgery is not possible.
  • Due to the low incidence of this neoplasm is not well established the best therapeutic approach.
  • We present the case of a female (35 years old) with a diagnosis of urethral adenocarcinoma.
  • Surgery was impossible and the patient received chemotherapy and radiotherapy.
  • [MeSH-major] Adenocarcinoma / therapy. Urethral Neoplasms / therapy

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  • (PMID = 15046483.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas espanolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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12. Koontz BF, Lee WR: Carcinoma of the urethra: radiation oncology. Urol Clin North Am; 2010 Aug;37(3):459-66

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the urethra: radiation oncology.
  • Urethral cancer is a rare but aggressive neoplasm.
  • Early-stage distal lesions can be successfully treated with a single modality.
  • Results for definitive radiotherapy using either or both external beam radiation therapy and brachytherapy have shown excellent cure rates in men and women.
  • Advanced tumors, however, have poor outcomes with single modality treatment.
  • Results have been improved using a combination of radiotherapy and chemotherapy, chiefly 5-fluorouracil and mitomycin C.
  • [MeSH-major] Carcinoma / radiotherapy. Urethral Neoplasms / radiotherapy
  • [MeSH-minor] Combined Modality Therapy. Humans. Neoplasm Staging

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20674700.001).
  • [ISSN] 1558-318X
  • [Journal-full-title] The Urologic clinics of North America
  • [ISO-abbreviation] Urol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Freiha F, Srinivas S: Invasive renal pelvis transitional cell carcinoma. J Clin Oncol; 2004 Jul 15;22(14_suppl):4694

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive renal pelvis transitional cell carcinoma.
  • : 4694 Background: Upper tract tumors of the renal pelvis and ureter represent a small proportion of patients with transitional cell carcinoma.
  • We report our experience with invasive renal pelvis and proximal ureter transitional cell carcinoma.
  • Of the 37 patients, 13 were ineligible (6= distal ureters; 3=non invasive cancers; 1=urethral cancer; 1=co existing lung cancer; 2=no follow up).
  • RESULTS: The median age was 72(47-92), 2/3 of the patients were men; renal pelvis was the primary site in 21, upper ureter in 3; 13 (54%) were smokers; ten patients (42%)had bladder tumors either preceding the renal pelvis tumor or after; six (25%) of the patients had distant metastases; ten (42%) had nodal metastases;The median overall survival was 27 months.
  • In those patients without nodal metastases, the T stage determined prognosis.
  • Adjuvant chemotherapy in this small series did not have an impact on survival.
  • The overall survival of patients with distant metastases in bladder cancer varies from 9 months to 33 months depending on the performance status and visceral metastases.
  • CONCLUSIONS: The median survival of patients with metastatic renal pelvis and upper tract tumors is worse than bladder cancer.
  • Early detection and adjuvant chemotherapy may have an impact and should be studied in larger number of patients.

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  • (PMID = 28015643.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Hamasaki T, Kondo Y, Ogata Y, Yoshida K, Kimura G, Shimizu H, Nishimura T: Advanced carcinoma of the prostatic urethra in a patient with marked response to chemotherapy, leading to preservation of the bladder. Int J Clin Oncol; 2010 Feb;15(1):109-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Advanced carcinoma of the prostatic urethra in a patient with marked response to chemotherapy, leading to preservation of the bladder.
  • Pathological examination diagnosed poorly differentiated urothelial carcinoma of the urethra with broad prostatic permeation.
  • Random bladder biopsies showed no malignancy, but a second TUR-P revealed urothelial carcinoma in the prostate and bladder neck.
  • Computed tomography (CT) showed lymph node metastases from para-aortic to right/left external iliac and left obturator nodes, so clinical stage T3N2M0 carcinoma of the prostatic urethra was diagnosed.
  • Given the presence of lymph node metastases, neoadjuvant chemotherapy using cisplatin 70 mg/m(2), ifosfamide 1.2 g/m(2) and docetaxel 70 mg/m(2) (PIT) was considered.
  • After chemotherapy, CT showed complete response (CR) of all lymph nodes.
  • Pathological findings of surgical specimens showed no residual carcinoma in the prostatic urethra or lymph nodes, although prostatic adenocarcinoma was recognized.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Prostatic Neoplasms / secondary. Urethral Neoplasms / drug therapy
  • [MeSH-minor] Aged. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Neoadjuvant Therapy. Prostatectomy. Prostatic Hyperplasia / surgery

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  • [Cites] Urology. 1996 Nov;48(5):703-10 [8911513.001]
  • [Cites] Am J Clin Pathol. 1963 Aug;40:183-9 [14060023.001]
  • [Cites] J Urol. 1973 Mar;109(3):457-60 [4348139.001]
  • [Cites] Am J Surg Pathol. 2001 Jun;25(6):794-801 [11395558.001]
  • [Cites] Hinyokika Kiyo. 2000 Jul;46(7):495-8 [10965459.001]
  • [Cites] Urology. 1984 Dec;24(6):544-9 [6506393.001]
  • [Cites] J Urol. 1997 Aug;158(2):338-41 [9224298.001]
  • [Cites] Br J Urol. 1979 Dec;51(6):575-8 [534844.001]
  • [Cites] J Urol. 2005 Nov;174(5):1771-5; discussion 1775-6 [16217281.001]
  • [Cites] Cancer. 2000 Apr 1;88(7):1671-8 [10738226.001]
  • [Cites] Urology. 2007 Jan;69(1 Suppl):50-61 [17280908.001]
  • [Cites] Hinyokika Kiyo. 1970 Apr;16(4):157-61 [5463380.001]
  • (PMID = 20087614.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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15. Sopena JM, González JA, Queralt MP, Sariol JC, Redorta JP, Mavrich HV: [Metastasic urethral squamous-cell a cancer]. Actas Urol Esp; 2009 Jun;33(6):712-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastasic urethral squamous-cell a cancer].
  • [Transliterated title] Carcinoma escamoso de uretra metastático.
  • Urethral cancer is an infrequent pathology, less than 1% of the genitourinary tumors.
  • The most frequent histology being squamous cell carcinoma.
  • The interval between the onset of symptoms and diagnosis may be as long as three years.
  • Therefore most of these tumors are locally advanced at the time of diagnosis with generally poor prognosis despite aggressive treatment.
  • Therapeutic management varies with the stage and location of the lesion.
  • Because of the rarity of this pathology, no consensus has been reached on treatment modalities, but seems to be that must be a multimodal one, including surgery, radiotherapy and chemotherapy.
  • We present the case of an 80 year-old male, with a diagnosis of urethral squamous-cell cancer, locally advanced at the time of diagnosis.
  • The patient underwent chemotherapy and radiotherapy with evidence of quick progression thereafter.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Urethral Neoplasms / secondary

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  • (PMID = 19711759.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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16. Dimarco DS, Dimarco CS, Zincke H, Webb MJ, Bass SE, Slezak JM, Lightner DJ: Surgical treatment for local control of female urethral carcinoma. Urol Oncol; 2004 Sep-Oct;22(5):404-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment for local control of female urethral carcinoma.
  • We reviewed 53 patients (mean age 63 years) who underwent partial urethrectomy (n = 26) or radical extirpation (n = 27) for primary female urethral cancer from 1948 through 1999.
  • Clinical stage, histology, high pathologic stage (3 or 4) and grade, tumor location, nodal status, surgery type, adjuvant therapy, and treatment decade were candidate outcome predictors.
  • For adjuvant therapy, 20 patients had radiation (8 preoperatively), 2 had radiation + chemotherapy, and 1 had chemotherapy alone.
  • Of patients undergoing partial urethrectomy for pT1-3 tumors, 6/27 (22%) had urethral recurrence.
  • Recurrence-free survival +/- standard error (SE) at 10 years was 45 + 8%.
  • Those who recurred had a cancer mortality rate of 71% at 5 years postrecurrence.
  • The estimated 10-year cancer-specific survival (CSS) and crude survival (CS) rates were 60 +/- 8% and 42 +/- 7%, respectively.
  • Upon review, partial urethrectomy resulted in a high urethral recurrence rate (22%) with no bladder recurrences.
  • [MeSH-major] Carcinoma / surgery. Neoplasm Recurrence, Local. Urethral Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Humans. Middle Aged. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Sex Factors. Treatment Outcome

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  • (PMID = 15464921.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Hakenberg OW, Franke HJ, Froehner M, Wirth MP: The treatment of primary urethral carcinoma--the dilemmas of a rare condition: experience with partial urethrectomy and adjuvant chemotherapy. Onkologie; 2001 Feb;24(1):48-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The treatment of primary urethral carcinoma--the dilemmas of a rare condition: experience with partial urethrectomy and adjuvant chemotherapy.
  • BACKGROUND: Primary urethral carcinoma is a very rare condition, and no large-scale experience with such cases has been published.
  • Treatment will therefore have to follow rules established for the treatment of similar conditions.
  • PATIENTS: Six cases of primary urethral carcinoma (5 male, 1 female) who had been treated at our institution between 1995 and 1999 were retrospectively analyzed.
  • In 3 male cases, a primary urothelial carcinoma of the distal urethra was treated by distal urethrectomy only.
  • In 3 other cases with locally advanced tumors and/or lymph node metastases surgical treatment was followed by adjuvant cisplatinum-containing chemotherapy.
  • RESULTS: In the 3 cases with distal urethral carcinoma, partial urethrectomy with preservation of the penis resulted in cure, with a follow-up of 12-71 months.
  • In the cases with advanced disease, adjuvant chemotherapy after surgery has resulted in complete remissions in all 3 cases, with a follow-up of 4-47 months at present.
  • CONCLUSIONS: In localized, noninvasive carcinoma of the distal male urethra, partial urethrectomy seems adequate and the avoidance of penile amputation justified.
  • In advanced cases, after local excision and lymphadenectomy adjuvant chemotherapy which by necessity must follow the guidelines established for the treatment of other urothelial or squamous cell malignancies seems to be beneficial.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Carcinoma, Transitional Cell / surgery. Urethral Neoplasms / surgery
  • [MeSH-minor] Adult. Biopsy. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Urethra / pathology. Urethra / surgery

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  • [Copyright] Copyright 2001 S. Karger GmbH, Freiburg
  • (PMID = 11441281.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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18. Parada D, Páez A, Acosta M, Caricote L, Trujillo E, Luigi JC, Farías RM: [Primary urothelial carcinoma of the bulbomembranous urethra. Histologic and immunohistochemical study of a case]. Arch Esp Urol; 2003 Dec;56(10):1144-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary urothelial carcinoma of the bulbomembranous urethra. Histologic and immunohistochemical study of a case].
  • [Transliterated title] Carcinoma urotelial primario de uretra bulbomembranosa. Estudio histológico e inmunohistoquímico de un caso.
  • OBJECTIVE: We report a case of a primary urothelial carcinoma of the bulbomembranous urethra, with special emphasis on histopathological and immunohistochemical findings.
  • METHODS/RESULTS: A 63-year-old man presented urethral obstruction symptoms.
  • A radical phalectomy was performed and a 4.5 x 4 cm bulbomembranous urethral tumor was observed.
  • Histopathological analysis disclosed an urothelial carcinoma, that showed positive immunostaining for cytokeratin AE1/AE3, cytokeratin 7, carcinoembrionic antigen and epithelial membrane antigen.
  • The patient received radiotherapy and adjuvant chemotherapy and is currently free of disease.
  • CONCLUSION: Posterior male urothelial carcinoma of the urethra is a rare neoplasm that usually is mistaken clinically for a benign lesion.
  • [MeSH-major] Carcinoma, Transitional Cell / pathology. Urethral Neoplasms / pathology

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  • (PMID = 14763421.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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19. Varol C, Thalmann GN, Burkhard FC, Studer UE: Treatment of urethral recurrence following radical cystectomy and ileal bladder substitution. J Urol; 2004 Sep;172(3):937-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of urethral recurrence following radical cystectomy and ileal bladder substitution.
  • PURPOSE: With the introduction of orthotopic bladder substitution after radical cystectomy in patients with invasive bladder cancer urethral recurrences have become a therapeutic challenge.
  • MATERIALS AND METHODS: We retrospectively evaluated our patients with urethral recurrences treated with a urethra sparing approach after orthotopic bladder substitution.
  • Depending on the extension of recurrence and eventual concomitant metastases patients were treated with urethrectomy, no treatment, systemic chemotherapy or intraurethral bacillus Calmette-Guerin (BCG).
  • Three times the common dose of BCG (ImmuCyst, Aventis, Paris, France or OncoTICE, Organon, West Orange, New Jersey) in 150 ml NaCl 0.9% was used for intraurethral BCG perfusion therapy according to an institutional protocol using a modified Foley catheter.
  • RESULTS: Between 1985 and 2001, 15 of 371 patients (4%) who received an orthotopic bladder substitute had urethral recurrence.
  • Two patients were treated with systemic chemotherapy (methotrexate, vinblastine, doxorubicin and cisplatin) alone due to metastatic disease and 10 received intraurethral BCG therapy.
  • Five of 6 patients (83%) with carcinoma in situ remained free of recurrence following treatment with BCG, while in 4 with papillary or invasive disease treatment failed.
  • Three patients underwent urethrectomy, including 2 following failed BCG therapy for papillary disease.
  • CONCLUSIONS: Carcinoma in situ urethral recurrence following orthotopic bladder substitution can be treated successfully with intraurethral BCG perfusion therapy in approximately 80% of patients.
  • However, papillary and invasive transitional cell urethral recurrence should be treated with urethrectomy.
  • [MeSH-major] Carcinoma, Transitional Cell / secondary. Carcinoma, Transitional Cell / therapy. Cystectomy. Urethral Neoplasms / secondary. Urethral Neoplasms / therapy. Urinary Bladder Neoplasms / surgery. Urinary Reservoirs, Continent
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. BCG Vaccine / administration & dosage. Humans. Male. Middle Aged. Urethra / surgery

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  • (PMID = 15311003.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / BCG Vaccine
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20. Tiguert R, Ravery V, Madjar S, Gousse AE: [Acute urinary retention secondary to clear cell adenocarcinoma of the urethra]. Prog Urol; 2001 Feb;11(1):70-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Acute urinary retention secondary to clear cell adenocarcinoma of the urethra].
  • [Transliterated title] Rétention urinaire aiguë secondaire à un adénocarcinome à cellules claires de l'urèthre.
  • The authors report a case of primary clear cell cancer of the urethra in a woman presenting with acute urinary retention.
  • The diagnosis was based on cystoscopy and confirmed by histological examination of urethral biopsies.
  • Treatment consisted of urethrocystectomy with creation of an "Indiana pouch".
  • She was treated with 3 courses of chemotherapy (mitomycin and 5-fluorouracil) combined with radiotherapy.
  • This case report emphasizes the rarity of this histological type and describes the management of urinary retention in a woman when an underlying specific disease is suspected.
  • [MeSH-major] Adenocarcinoma, Clear Cell / complications. Urethral Neoplasms / complications. Urinary Retention / etiology

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  • (PMID = 11296650.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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21. Troiano M, Corsa P, Raguso A, Cossa S, Piombino M, Guglielmi G, Parisi S: Radiation therapy in urinary cancer: state of the art and perspective. Radiol Med; 2009 Feb;114(1):70-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation therapy in urinary cancer: state of the art and perspective.
  • Invasive urinary tumours are relatively rare, and their treatment may cause important changes in urinary, sexual and social functions.
  • A systematic review of external radiation therapy studies in urinary cancers was performed.
  • There are few controlled clinical trials using adjuvant or radical radiotherapy with or without chemotherapy in cancer of the kidney, ureter and urethra.
  • There are several reports on multimodality treatment in invasive bladder cancer: intravesical surgery and neoadjuvant chemotherapy to radiotherapy or concomitant radiochemotherapy with organ preservation.
  • The conclusions reached for renal cancer are controversial, and data on cancers of the urethra and ureter are few and inconclusive.
  • Sufficient data now exist in the literature to demonstrate that conservative management with organ preservation is a valuable alternative to radical cystectomy, the traditional gold standard, in invasive bladder cancer.
  • [MeSH-minor] Brachytherapy. Combined Modality Therapy. Controlled Clinical Trials as Topic. Cystectomy. Data Interpretation, Statistical. Dose Fractionation. Female. Humans. Kidney / pathology. Kidney Neoplasms / mortality. Kidney Neoplasms / pathology. Kidney Neoplasms / radiotherapy. Kidney Neoplasms / surgery. Male. Meta-Analysis as Topic. Neoplasm Staging. Nephrectomy. Organ Preservation. Prospective Studies. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Time Factors. Ureter / pathology. Ureteral Neoplasms / drug therapy. Ureteral Neoplasms / mortality. Ureteral Neoplasms / pathology. Ureteral Neoplasms / radiotherapy. Urethra / pathology. Urethral Neoplasms / drug therapy. Urethral Neoplasms / mortality. Urethral Neoplasms / pathology. Urethral Neoplasms / radiotherapy. Urinary Bladder / pathology. Urinary Bladder Neoplasms / pathology. Urinary Bladder Neoplasms / radiotherapy. Urinary Bladder Neoplasms / surgery

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  • [Cites] Radiother Oncol. 2000 Jul;56(1):29-35 [10869752.001]
  • [Cites] Oncologist. 2000;5(6):471-6 [11110598.001]
  • [Cites] Anticancer Res. 1998 May-Jun;18(3B):1931-4 [9677446.001]
  • [Cites] Am J Clin Oncol. 2003 Dec;26(6):558-62 [14663371.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1998 Jan 1;40(1):121-7 [9422567.001]
  • [Cites] Cancer. 2004 Dec 1;101(11):2540-8 [15481058.001]
  • [Cites] Cancer. 1994 Nov 15;74(10):2819-27 [7954243.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Aug 30;33(1):173-8 [7642415.001]
  • [Cites] Radiother Oncol. 1997 May;43(2):155-7 [9192960.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1992;23(3):511-7 [1612951.001]
  • [Cites] J Urol. 1958 Feb;79(2):196-201 [13514867.001]
  • [Cites] J Urol. 2004 Oct;172(4 Pt 1):1271-5 [15371822.001]
  • [Cites] Radiother Oncol. 1992 May;24(1):41-4 [1620886.001]
  • [Cites] J Urol. 1982 Apr;127(4):671-4 [7069829.001]
  • [Cites] Strahlenther Onkol. 2005 Oct;181(10):632-7 [16220401.001]
  • [Cites] Semin Surg Oncol. 1997 May-Jun;13(3):208-14 [9143060.001]
  • [Cites] Radiother Oncol. 2005 Apr;75(1):34-43 [15878099.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1994 Feb 1;28(3):783 [8113125.001]
  • [Cites] J Clin Oncol. 2006 Dec 10;24(35):5536-44 [17158539.001]
  • [Cites] Cancer. 1993 Nov 15;72(10):3044-51 [8221572.001]
  • [Cites] Urology. 1977 Nov;10(5):414-7 [411207.001]
  • [Cites] Radiology. 1994 Dec;193(3):725-30 [7972814.001]
  • [Cites] J Clin Oncol. 2002 Jul 15;20(14):3061-71 [12118019.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1997 Jan 15;37(2):259-67 [9069295.001]
  • [Cites] Urology. 2002 Jul;60(1):62-7; discussion 67-8 [12100923.001]
  • [Cites] Anticancer Res. 1997 Nov-Dec;17(6D):4771-80 [9494605.001]
  • [Cites] J Urol. 1996 Jun;155(6):1903-6 [8618283.001]
  • [Cites] Lancet. 2003 Jun 7;361(9373):1927-34 [12801735.001]
  • [Cites] Int J Cancer. 2000 Oct 20;90(5):287-94 [11091353.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1990 Sep;19(3):693-9 [2211217.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1993 Apr 2;25(5):783-90 [8478228.001]
  • [Cites] Cancer. 1970 Jan;25(1):26-40 [5410313.001]
  • [Cites] Tumori. 2006 May-Jun;92(3):202-6 [16869236.001]
  • [Cites] J Clin Oncol. 1996 Nov;14(11):2901-7 [8918486.001]
  • [Cites] Transplantation. 1986 Jan;41(1):63-6 [3510497.001]
  • [Cites] Semin Oncol. 1983 Dec;10(4):417-21 [6198728.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1992;24(3):463-8 [1399731.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):665-72 [14529770.001]
  • [Cites] Neoplasma. 1998;45(6):380-3 [10210113.001]
  • [Cites] Radiother Oncol. 2005 Apr;75(1):44-7 [15878100.001]
  • [Cites] Strahlentherapie. 1985 Nov;161(11):673-7 [3907021.001]
  • [Cites] J Urol. 1998 Nov;160(5):1673-7 [9783929.001]
  • [Cites] J Urol. 1997 Mar;157(3):805-7; discussion 807-8 [9072571.001]
  • [Cites] Urology. 1995 Oct;46(4):499-504; discussion 504-5 [7571218.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1998 May 1;41(2):273-8 [9607341.001]
  • [Cites] J Surg Oncol. 1983 Aug;23(4):263-8 [6876802.001]
  • [Cites] J Clin Oncol. 2001 Feb 1;19(3):666-75 [11157016.001]
  • [Cites] J Urol. 1970 Jul;104(1):53-61 [5426710.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1998 Jun 1;41(3):535-41 [9635699.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1168-73 [16376486.001]
  • [Cites] Clin Oncol (R Coll Radiol). 2006 Feb;18(1):52-9 [16477920.001]
  • [Cites] Acta Oncol. 2006;45(7):870-5 [16982552.001]
  • [Cites] Int Urol Nephrol. 1984;16(1):29-32 [6724827.001]
  • [Cites] Cancer. 1988 Jan 15;61(2):255-62 [3334959.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2003 Jul 1;56(3):726-33 [12788178.001]
  • [Cites] Radiother Oncol. 2005 Oct;77(1):88-95 [15972239.001]
  • [Cites] J Clin Oncol. 1993 Nov;11(11):2150-7 [8229129.001]
  • [Cites] Br J Urol. 1982 Apr;54(2):136-51 [7044462.001]
  • [Cites] J Chin Med Assoc. 2005 Nov;68(11):522-30 [16323396.001]
  • [Cites] J Urol. 1991 Jan;145(1):45-50 [1984097.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 May 15;32(2):331-40 [7751174.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2003 Dec 1;57(5):1310-6 [14630267.001]
  • [Cites] J Urol. 2001 Apr;165(4):1111-6 [11257649.001]
  • [Cites] Urology. 2004 Jan;63(1):73-7 [14751352.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1990 May;18(5):1131-7 [2347721.001]
  • [Cites] Radiother Oncol. 1999 Jul;52(1):1-14 [10577680.001]
  • [Cites] Lancet. 1999 Aug 14;354(9178):533-40 [10470696.001]
  • [Cites] J Clin Oncol. 1997 Mar;15(3):1022-9 [9060542.001]
  • [Cites] Tumori. 2002 Nov-Dec;88(6):500-2 [12597146.001]
  • [Cites] J Clin Oncol. 1998 Nov;16(11):3576-83 [9817278.001]
  • [Cites] Strahlentherapie Sonderb. 1981;76:169-75 [7303093.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2000 May 1;47(2):373-8 [10802362.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1987 May;13(5):665-72 [3553111.001]
  • [Cites] Br J Cancer. 2004 Jun 1;90(11):2106-11 [15150587.001]
  • [Cites] J Clin Oncol. 1996 Jan;14(1):119-26 [8558186.001]
  • [Cites] Br J Urol. 1997 Jul;80(1):44-9 [9240179.001]
  • [Cites] Scand J Urol Nephrol. 1977;11(3):277-81 [594674.001]
  • (PMID = 19082788.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 80
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22. Dalbagni G, Donat SM, Eschwège P, Herr HW, Zelefsky MJ: Results of high dose rate brachytherapy, anterior pelvic exenteration and external beam radiotherapy for carcinoma of the female urethra. J Urol; 2001 Nov;166(5):1759-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Results of high dose rate brachytherapy, anterior pelvic exenteration and external beam radiotherapy for carcinoma of the female urethra.
  • PURPOSE: We evaluated a multimodality approach to locally advanced urethral carcinoma in women.
  • MATERIALS AND METHODS: Between August 1996 and July 1999, 6 women were treated for locally advanced carcinoma of the urethra with anterior pelvic exenteration followed by high dose 192iridium intraoperative radiation therapy.
  • Four of the 6 patients were also treated with neoadjuvant or concomitant platinum based chemotherapy.
  • [MeSH-major] Brachytherapy. Carcinoma, Transitional Cell / radiotherapy. Carcinoma, Transitional Cell / surgery. Pelvic Exenteration. Urethral Neoplasms / radiotherapy. Urethral Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Humans. Middle Aged. Neoplasm Recurrence, Local. Survival Analysis

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  • (PMID = 11586218.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Nicholson S, Tsang D, Summerton D: Aggressive combined-modality therapy for squamous cell carcinoma of the female urethra. Nat Clin Pract Urol; 2008 Oct;5(10):574-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive combined-modality therapy for squamous cell carcinoma of the female urethra.
  • INVESTIGATIONS: Pelvic examination under anesthetic by both a urologist and gynecologist, biopsy of the urethral tumor and of the cervix, pathological analysis, MRI of the pelvis, CT of the chest, abdomen and pelvis.
  • DIAGNOSIS: Poorly differentiated squamous cell carcinoma of the urethra, T4N0M0.
  • MANAGEMENT: The patient received two cycles of neoadjuvant TIP (paclitaxel, ifosfamide, cisplatin) chemotherapy, resulting in complete remission, followed by consolidative chemoradiation therapy (radiation therapy given with synchronous weekly cisplatin).
  • She remained relapse-free 48 months after diagnosis, with normal voiding and sexual function.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Urethral Neoplasms / drug therapy. Urethral Neoplasms / radiotherapy
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Middle Aged

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  • (PMID = 18762780.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Xiao MZ, Gou X, He ZM: [Diagnosis and treatment of urethral condyloma acuminatum in male patients]. Zhonghua Nan Ke Xue; 2002;8(2):112-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and treatment of urethral condyloma acuminatum in male patients].
  • OBJECTIVES: To present experience on the diagnosis and treatment of urethral condyloma acuminatum (CA) in male patients.
  • METHODS: Twenty-one cases of urethral CA were studied.
  • The lesion of urethral meatus and intraurethal were resected by electrofulguration or operation and Urethroscopy, respectively.
  • All patients were received intraurethral instillation and local therapy of 5% 5-fluorouracil solution.
  • CONCLUSIONS: Transurethral endoscopy is a reliable diagnosis and treatment method.
  • Intraurethral instillation and local therapy of 5% 5-fluorouracil solution may prevent the recurrence of CA.
  • [MeSH-major] Condylomata Acuminata / diagnosis. Fluorouracil / therapeutic use. Urethral Diseases / diagnosis
  • [MeSH-minor] Follow-Up Studies. Humans. Instillation, Drug. Male. Treatment Outcome

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  • MedlinePlus Health Information. consumer health - Urethral Disorders.
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  • (PMID = 12479023.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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25. Tazi K, Moudouni S, Karmouni T, Koutani A, Hachimi M, Lakrissa A: [Epidermoid carcinoma of the male urethra]. Prog Urol; 2000 Sep;10(4):600-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Epidermoid carcinoma of the male urethra].
  • [Transliterated title] Carcinome épidermoïde de l'urèthre masculin.
  • Squamous cell carcinoma of the male urethra is exceptional, as all urethral tumours represent less than 1% of urinary tract tumours.
  • Treatment depends on the stage and site of the lesion, but the prognosis remains very poor despite aggressive treatment, including mutilating resection surgery with or without associated radiotherapy.
  • However, the current hope for patients with squamous cell carcinoma of the urethra resides in radiotherapy-chemotherapy combination protocols based on the results obtained in squamous cell cancers of the oesophagus and anus.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Urethral Neoplasms / diagnosis

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  • (PMID = 11064906.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] FRANCE
  • [Number-of-references] 15
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26. Ruoppolo M, Gozo M, Milesi R, Spina R, Fragapane G: [Urethral recurrence of invasive carcinoma following BCG treatment for bladder Ca in situ]. Urologia; 2010 Oct-Dec;77 Suppl 17:72-7
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  • [Title] [Urethral recurrence of invasive carcinoma following BCG treatment for bladder Ca in situ].
  • [Transliterated title] Recidiva uretrale di Ca infiltrante dopo trattamento con BCG per Ca in situ vescicale.
  • CIS is a flat, high-grade, non-invasive microscopic urothelial carcinoma.
  • It is considered a precursor of invasive bladder cancer.
  • CIS is classified as primary, secondary or concurrent, when occurred as isolated CIS without cuncurrent papillary tumors, or detected during the follow-up of patients with a previous papillary tumor, or finally in the presence of bladder neoplasm.
  • BCG is widely established as the treatment of choice for CIS with a success rate of approximately 70%.
  • BCG reduces the risk of progression of CIS into invasive carcinoma in 30 to 50% of cases.
  • Direct and prolonged contact between the urothelium and BCG is a prerequisite for successful therapy.
  • Discovery of CIS in the prostatic or membranous urethra represents an ominous sign.
  • CIS may be present only in the epithelial lining of the prostatic urethra or in the ducts, or in the worst case it may be found in the prostatic tissue stroma.
  • Urethral involvement by CIS is at high risk of tumor progression and development of metastases due to reduced thickness of lamina propria and absence of muscolaris mucosa.
  • 83 patients, enrolled from 1/1996 to 12/2005 at our urological department with CIS: primary (focal and multifocal) in 25, secondary in 7 and cuncurrent in 51 (associated with T1bG3 cancer in 37 cases), and urethral CIS in 5 and conservatively treated by TUR and intravescical instillations of BCG, 4 developed afterwords only invasive cancer of the urethra in the absence of bladder involvement.
  • In 2 cases cancer arised from the prostatic fossa after TURP, in 1 from membranous urethra and in the last from prostatic ducts.
  • Among the 4 patients, 3 were treated by cystoprostatourethrectomy and Platinum-based chemotherapy, 1 refused surgical treatment.
  • In the last patient cancer relapsed at 36-month's follow-up.
  • We conclude that prostatic/urethral involvement during follow-up after successful intravesical treatment with BCG in CIS represents a high risk of developing invasive and incontrolled cancer.
  • [MeSH-major] BCG Vaccine / therapeutic use. Carcinoma in Situ / therapy. Carcinoma, Transitional Cell / secondary. Urethral Neoplasms / secondary. Urinary Bladder Neoplasms / therapy
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Cystectomy / methods. Disease Progression. Female. Follow-Up Studies. Humans. Immunotherapy. Male. Neoplasm Invasiveness. Organoplatinum Compounds / administration & dosage. Prostatectomy / methods. Prostatic Neoplasms / secondary. Risk. Treatment Outcome. Urethra / surgery

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  • (PMID = 21308679.001).
  • [ISSN] 1724-6075
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BCG Vaccine; 0 / Organoplatinum Compounds
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27. Iborra F, Rigaud J, Bastide C, Mottet N, les membres du sous-comité organes génitaux externes du comité de cancérologie de l'AFU: [Treatment of primary urethral carcinoma. Guidelines from the French Urological Association. Cancer committee]. Prog Urol; 2009 Mar;19(3):170-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of primary urethral carcinoma. Guidelines from the French Urological Association. Cancer committee].
  • [Transliterated title] Prise en charge thérapeutique des tumeurs de l'urètre. Recommandations du comité de cancérologie de l'Association française d'urologie.
  • The litterature dealing with the treatment of primary uretral carcinoma is very limited.
  • The treatment modality is mainly based on the lesion topography and not on the histology.
  • For more advanced lesions, the combination of radiotherapy and chemotherapy is the standard of care.
  • [MeSH-major] Carcinoma / therapy. Urethral Neoplasms / therapy
  • [MeSH-minor] BCG Vaccine / therapeutic use. Brachytherapy. Chemotherapy, Adjuvant. France. Humans. Radiotherapy, Adjuvant

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  • (PMID = 19268254.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Practice Guideline; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / BCG Vaccine
  • [Number-of-references] 28
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28. Ouzaid I, Hermieu JF, Dominique S, Fernandez P, Choudat L, Ravery V: Management of adenocarcinoma of the female urethra: case report and brief review. Can J Urol; 2010 Oct;17(5):5404-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of adenocarcinoma of the female urethra: case report and brief review.
  • INTRODUCTION: We present a case of a differentiated adenocarcinoma of the female urethra, which caused dysuria and voiding dysfunction.
  • RESULTS: An ultrasound-guided biopsy showed a urethral carcinoma.
  • A magnetic resonance imaging (MRI) scan showed a high-stage tumor.
  • CONCLUSION: Urethral carcinoma is a rare malignancy.
  • A biopsy is necessary to make a diagnosis.
  • MRI is the best imaging for tumor staging.
  • Advanced disease should be treated with a multimodality of options including neoadjuvant radiotherapy given concomitantly with chemotherapy followed by surgery.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Urethral Neoplasms / radiotherapy. Urethral Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Middle Aged. Pelvic Exenteration. Treatment Outcome. Urologic Surgical Procedures / adverse effects

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  • (PMID = 20974039.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
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29. Chen Q, Huang Z, Luck D, Beckers J, Brun PH, Wilson BC, Scherz A, Salomon Y, Hetzel FW: Preclinical studies in normal canine prostate of a novel palladium-bacteriopheophorbide (WST09) photosensitizer for photodynamic therapy of prostate cancers. Photochem Photobiol; 2002 Oct;76(4):438-45
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preclinical studies in normal canine prostate of a novel palladium-bacteriopheophorbide (WST09) photosensitizer for photodynamic therapy of prostate cancers.
  • Photodynamic therapy (PDT) uses light to activate a photosensitizer to achieve localized tumor control.
  • In this study, PDT mediated by a second-generation photosensitizer, palladium-bacteriopheophorbide WST09 (Tookad) was investigated as an alternative therapy for prostate cancer.
  • PDT was performed by irradiating the surgically exposed prostate superficially or interstitially at 763 nm to different total fluences (100 or 200 J/cm2; 50, 100 or 200 J/cm) at 5 or 15 min after intravenous administration of the drug (2 mg/kg).
  • All animals recovered well, without urethral complications.
  • During the 1 week to 3 month post-treatment period, the prostates were harvested for histopathological examination.
  • The PDT-induced lesions showed uniform hemorrhagic necrosis and atrophy, were well delineated from the adjacent normal tissue and increased linearly in diameter with the logarithm of the delivered light fluence.
  • A maximum PDT-induced lesion size of over 3 cm diameter could be achieved with a single interstitial treatment.
  • At therapeutic PDT levels, there was no structural or functional urethral damage even when the urethra was within the treated region.
  • Hence, Tookad-PDT appears to be a promising candidate for prostate ablation in patients with recurrent, or possibly even primary, prostate cancer.
  • [MeSH-major] Bacteriochlorophylls / pharmacology. Photochemotherapy. Photosensitizing Agents / pharmacology. Prostate / drug effects. Prostatic Neoplasms / drug therapy

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  • (PMID = 12405153.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01-CA43892
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacteriochlorophylls; 0 / Photosensitizing Agents; 0 / palladium-bacteriopheophorbide
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30. Hettiarachchi JA, Johnson GB, Panageas E, Drinis S, Konno S, Das AK: Malignant priapism associated with metastatic urethral carcinoma. Urol Int; 2001;66(2):114-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant priapism associated with metastatic urethral carcinoma.
  • We present a 40-year-old man with malignant priapism secondary to urethral squamous cell carcinoma.
  • Magnetic resonance imaging revealed the tumor originating from the bulbous urethra, extending into the penile urethra and corpora spongiosa and cavernosa.
  • A penile biopsy confirmed poorly differentiated squamous cell carcinoma of the urethra.
  • Despite administration of systemic chemotherapy, the prognosis of the patient has worsened due to the extensive metastatic disease.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / secondary. Priapism / etiology. Urethral Neoplasms / complications. Urethral Neoplasms / secondary

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  • [Copyright] Copyright 2001 S. Karger AG, Basel
  • (PMID = 11223757.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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31. Place RJ, Gregorcyk SG, Huber PJ, Simmang CL: Outcome analysis of HIV-positive patients with anal squamous cell carcinoma. Dis Colon Rectum; 2001 Apr;44(4):506-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome analysis of HIV-positive patients with anal squamous cell carcinoma.
  • PURPOSE: With improved antiretroviral therapy, HIV-positive patients are achieving a longer life expectancy.
  • METHODS: We conducted a review based on our tumor registry from 1980 through 1999.
  • We identified 73 patients with anal squamous cell carcinoma treated at the University of Texas Southwestern Medical Center affiliated hospitals; 23 were HIV positive (18 had AIDS).
  • Data collected included age, CD4 count, treatment, complications, and survival; these data were analyzed by Student's t-test.
  • Those with squamous cell cancer of the anus were offered radiation therapy and chemotherapy.
  • Beginning in 1998, all patients received highly active antiretroviral therapy before treatment.
  • Seven of 14 anal squamous cell carcinoma patients had their therapy adjusted owing to toxicity.
  • Morbidity included proctocolitis and diarrhea (n = 2) requiring diversion (n = 1), hemorrhagic cystitis (n = 1), neutropenic fever (n = 3), bone marrow suppression (n = 1), and urethral stricture (n = 1).
  • Mean age was 42 years for anal squamous cell carcinoma patients and 36 years for squamous cell carcinoma in situ patients (P = 0.05).
  • Mean CD4 count was 222 cells/ml in patients with infiltrating carcinoma and 200 in the in situ patients (P = NS).
  • One-year and five-year mortality rates, respectively, were 40 percent and 80 percent for infiltrating carcinoma patients and 17 percent and 50 percent for the in situ patients.
  • Both of the in situ patients who died had CD4 counts <20 cells/ml at diagnosis, whereas the rest had CD4 counts >100 cells/ml and are currently without anal disease.
  • Mean CD4 count at diagnosis for all patients who died was 133 cells/ml, whereas for those surviving, it was 261 cells/ml (P = 0.03).
  • Eight (all with infiltrating carcinoma) of the 10 patients who died had persistent anal disease, but none had metastasis.
  • A low CD4 count at diagnosis without highly active antiretroviral therapy predicts a poor prognosis.
  • Because these patients appear to succumb to their HIV status and not the anal disease, anal squamous cell carcinoma should be included with cervical squamous cell carcinoma as an AIDS-defining illness.
  • HIV-positive patients, particularly AIDS patients, with invasive anal cancers and without effective antiretroviral therapy obtain little benefit and significant toxicity from current radiation therapy and chemotherapy.
  • Initiation of highly active antiretroviral therapy in HIV-positive patients before radiation therapy and chemotherapy are begun may decrease toxicity and improve survival.
  • [MeSH-major] Anus Neoplasms / complications. Carcinoma in Situ / complications. Carcinoma, Squamous Cell / complications. HIV Infections / complications
  • [MeSH-minor] Adult. Antiretroviral Therapy, Highly Active. CD4 Lymphocyte Count. Combined Modality Therapy. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome


32. Lee JS, Chang JS, Lee JY, Kim JA: Capsaicin-induced apoptosis and reduced release of reactive oxygen species in MBT-2 murine bladder tumor cells. Arch Pharm Res; 2004 Nov;27(11):1147-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Capsaicin-induced apoptosis and reduced release of reactive oxygen species in MBT-2 murine bladder tumor cells.
  • Bladder cancer is a common cancer with high risk of recurrence and mortality.
  • Intravesicle chemotherapy after trans-urethral resection is required to prevent tumor recurrence and progression.
  • It has been known that antioxidants enhance the antitumor effect of bacillus Calmette-Guerin (BCG), the most effective intravesical bladder cancer treatment.
  • Capsaicin, the major pungent ingredient in genus Capsicum, has recently been tried as an intravesical drug for overactive bladder and it has also been shown to induce apoptotic cell death in many cancer cells.
  • In this study, we investigated the apoptosis-inducing effect and alterations in the cellular redox state of capsaicin in MBT-2 murine bladder tumor cells.
  • Capsaicin induced apoptotic MBT-2 cell death in a time- and dose-dependent manner.
  • Furthermore, capsaicin at the concentration of inducing apoptosis also markedly reduced the level of reactive oxygen species and lipid peroxidation, implying that capsaicin may enhance the antitumor effect of BCG in bladder cancer treatment.
  • These results further suggest that capsaicin may be a valuable intravesical chemotherapeutic agent for bladder cancers.
  • [MeSH-major] Apoptosis / drug effects. Capsaicin / pharmacology. Reactive Oxygen Species / metabolism
  • [MeSH-minor] Amino Acid Chloromethyl Ketones / pharmacology. Animals. Blotting, Western. Caspase 3. Caspase Inhibitors. Caspases / metabolism. Cell Line, Tumor. Cysteine Proteinase Inhibitors / pharmacology. Cytochromes c / metabolism. Cytosol / drug effects. Cytosol / metabolism. DNA Fragmentation / drug effects. Electrophoresis, Agar Gel. Enzyme Activation / drug effects. Flow Cytometry. Mice. Mitochondria / drug effects. Mitochondria / metabolism. Oligopeptides / pharmacology. Proto-Oncogene Proteins c-bcl-2 / metabolism. Time Factors. Urinary Bladder Neoplasms / metabolism. Urinary Bladder Neoplasms / pathology. bcl-2-Associated X Protein

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  • (PMID = 15595419.001).
  • [ISSN] 0253-6269
  • [Journal-full-title] Archives of pharmacal research
  • [ISO-abbreviation] Arch. Pharm. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Amino Acid Chloromethyl Ketones; 0 / Bax protein, mouse; 0 / Caspase Inhibitors; 0 / Cysteine Proteinase Inhibitors; 0 / Oligopeptides; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Reactive Oxygen Species; 0 / aspartyl-glutamyl-valyl-aspartal; 0 / bcl-2-Associated X Protein; 0 / benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; 9007-43-6 / Cytochromes c; EC 3.4.22.- / Casp3 protein, mouse; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases; S07O44R1ZM / Capsaicin
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33. Murphy DR, Morris NJ: Transitional cell carcinoma of the urethra [correction of ureter] in a patient with buttock pain: a case report. Arch Phys Med Rehabil; 2008 Jan;89(1):150-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transitional cell carcinoma of the urethra [correction of ureter] in a patient with buttock pain: a case report.
  • This case reports on a patient with an unusual presentation of a rare tumor: urethral transitional cell carcinoma (TCC).
  • Urethral TCC occurs in approximately 0.7% to 4.0% of patients who have had primary bladder cancer.
  • The patient was initially suspected to have piriformis syndrome, but when he did not respond as expected to treatment, and because of his history of primary bladder cancer, further evaluation was undertaken and the diagnosis was made.
  • The patient responded well to radiation and chemotherapy.
  • Musculoskeletal physicians should be particularly suspicious of the presence of urethral TCC in a patient with a history of primary bladder cancer who reports low back or buttock pain, particularly if the patient does not respond quickly to treatment.
  • [MeSH-major] Carcinoma, Transitional Cell / complications. Low Back Pain / etiology. Urethral Neoplasms / complications
  • [MeSH-minor] Aged. Buttocks. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Neoplasms, Multiple Primary. Prostatic Neoplasms. Urinary Bladder Neoplasms

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  • (PMID = 18164345.001).
  • [ISSN] 1532-821X
  • [Journal-full-title] Archives of physical medicine and rehabilitation
  • [ISO-abbreviation] Arch Phys Med Rehabil
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Parisi S, Troiano M, Corsa P, Raguso A, Cossa S, Piazzolla EE, Munafò T, Sanpaolo G, Natuno A, Maiello E: Role of external radiation therapy in urinary cancers. Ann Oncol; 2007 Jun;18 Suppl 6:vi157-61
MedlinePlus Health Information. consumer health - Bladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of external radiation therapy in urinary cancers.
  • Invasive urinary tumors are relatively rare and their treatment may cause important changes in urinary, sexual, and social functions.
  • A systematic review of external radiation therapy studies in urinary cancers has been carried out.
  • There are few controlled clinical trials using adjuvant or radical radiotherapy +/- chemotherapy in kidney, ureter, and urethra cancers; there are several reports of muscle-invasive bladder cancer using multimodality treatment: intravesical surgery and neo-adjuvant chemotherapy to radiotherapy or concomitant radiochemotherapy with organ preservation.
  • The conclusions reached for renal cancer are controversial; urethra and ureter cancers data are few and inconclusive; sufficient data now exist in literature to demonstrate that conservative management with organ preservation, for muscle-invasive bladder cancer, is a valid alternative to radical cystectomy, viewed as the gold standard.

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  • (PMID = 17591812.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 34
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35. Palou J, Baniel J, Klotz L, Wood D, Cookson M, Lerner S, Horie S, Schoenberg M, Angulo J, Bassi P: Urothelial carcinoma of the prostate. Urology; 2007 Jan;69(1 Suppl):50-61
MedlinePlus Health Information. consumer health - Prostate Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Urothelial carcinoma of the prostate.
  • This study was conducted to explore the diagnosis and management of urothelial carcinoma of the prostate in superficial disease and carcinoma in situ, stromal invasion, primary urothelial carcinoma, and urethral recurrence after radical surgery.
  • A consensus conference convened by the World Health Organization (WHO) and the Société Internationale d'Urologie (SIU) reviewed the diagnosis and management of urothelial carcinoma of the bladder.
  • English-language literature about urothelial carcinoma of the prostate was identified and reviewed.
  • Evidence-based recommendations for the diagnosis and management of urothelial carcinoma were made.
  • Many recommendations were level 3 or 4 citations involving the diagnosis and management of superficial urothelial carcinoma; a few were level 2 citations.
  • Level 1 citations related only to chemotherapy and radiotherapy in patients with stromal invasion, although these were not related specifically to invasive prostatic involvement.
  • Published reports on the diagnosis and treatment of superficial urothelial disease of the prostate primarily consist of short case series from individual centers.
  • In invasive disease of the prostate, the only large series were designed to investigate invasive bladder cancer.
  • [MeSH-major] Carcinoma, Transitional Cell. Prostatic Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Global Health. Humans. Incidence. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Prognosis. Prostatectomy

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  • (PMID = 17280908.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 65
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36. VanderMolen LA, Sheehy PF, Dillman RO: Successful treatment of transitional cell carcinoma of the urethra with chemotherapy. Cancer Invest; 2002;20(2):206-7
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  • [Title] Successful treatment of transitional cell carcinoma of the urethra with chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Transitional Cell / drug therapy. Urethral Neoplasms / drug therapy

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  • (PMID = 11901541.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; YL5FZ2Y5U1 / Methotrexate; M-VAC protocol
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