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1. Pouessel D, Thezenas S, Culine S, Becht C, Senesse P, Ychou M: Hepatic metastases from carcinomas of unknown primary site. Gastroenterol Clin Biol; 2005 Dec;29(12):1224-32
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  • [Title] Hepatic metastases from carcinomas of unknown primary site.
  • AIM: Hepatic metastases are often present at diagnosis of carcinoma of unknown primary site (CUP).
  • The objective of this study was to describe the diagnostic and therapeutic strategies used.
  • METHODS: One hundred and eighteen patients were treated at the Cancer Center of Montpellier from 1993 to 2002 for CUP initially metastatic to the liver.
  • RESULTS: The most frequent histological types observed were adenocarcinoma, undifferentiated, neuroendocrine and squamous-cell carcinomas.
  • Pretreatment computed tomography scans of the chest, abdomen and pelvis evaluation were available for more than 80% of patients.
  • One hundred and seven patients had received at least a front-line of chemotherapy.
  • Seventy-four patients had received platin salt-based chemotherapy, 67 in front-line treatment and 10 in second line.
  • In first-line chemotherapy, overall response rates with or without platin were 19.4 and 20% respectively.
  • CONCLUSIONS: According to this study, pretreatment evaluations, which were very extensive in some patients, were insufficient to identify the primary site of liver metastases.
  • Because of the poor prognostic, chemotherapy, in absence of clinically demonstrated benefit, has to be reserved for patients with better prognosis.
  • [MeSH-major] Liver Neoplasms / mortality. Liver Neoplasms / secondary. Neoplasms, Unknown Primary / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma / mortality. Carcinoma / secondary. Carcinoma / therapy. Female. France / epidemiology. Humans. L-Lactate Dehydrogenase / blood. Male. Middle Aged. Multivariate Analysis. Neuroendocrine Tumors / mortality. Neuroendocrine Tumors / secondary. Neuroendocrine Tumors / therapy. Prognosis. Retrospective Studies

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  • (PMID = 16518276.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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2. Endo K, Kohnoe S, Toh Y, Haraguchi M, Nishiyama K, Okamura T, Baba H, Maehara Y: A case of esophageal small cell carcinoma with multiple liver metastases responding to chemotherapy with irinotecan plus cisplatin. J Exp Clin Cancer Res; 2005 Dec;24(4):647-50
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  • [Title] A case of esophageal small cell carcinoma with multiple liver metastases responding to chemotherapy with irinotecan plus cisplatin.
  • We report a case of small cell esophageal carcinoma (SCEC) with multiple liver metastases treated with some success by chemotherapy with irinotecan (CPT-11) plus cisplatin (CDDP).
  • Radiologic and endoscopic examination of a 75-year-old man with multiple liver tumors disclosed a 4.0-cm type 2 tumor in the middle third of the esophagus.
  • An endoscopically obtained biopsy specimen was diagnosed as undifferentiated small cell carcinoma.
  • Multiple liver metastases were confirmed but lymph node metastases and distant metastases other than those in the liver were not detected.
  • After six courses of chemotherapy with CPT-11 plus CDDP, the primary lesion showed complete response and liver metastases showed partial response.
  • However, because all lesions almost immediately relapsed or progressed, arterial infusion chemotherapy for liver metastases and radiation for the primary lesion were given as second-line treatment.
  • The primary lesion showed complete response with radiation.
  • Arterial infusion chemotherapy prevented the progression of liver metastases once, but the patient died of liver failure at last.
  • No distant lesions including metastatic lymph nodes were confirmed over the course of his illness, and the patient survived for a year after first diagnosis.
  • Although the prognosis of SCEC is quite unfavorable due to highly aggressive behavior, a better prognosis is possible with effective chemotherapy and second-line treatment is important in improving prognosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Esophageal Neoplasms / drug therapy. Liver Neoplasms / drug therapy
  • [MeSH-minor] Aged. Camptothecin / analogs & derivatives. Camptothecin / therapeutic use. Cisplatin / therapeutic use. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 16471329.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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3. Thurnher D, Kletzmayr J, Formanek M, Quint C, Czerny C, Burian M, Kornek G: Chemotherapy-related hemolytic-uremic syndrome following treatment of a carcinoma of the nasopharynx. Oncology; 2001;61(2):143-6
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  • [Title] Chemotherapy-related hemolytic-uremic syndrome following treatment of a carcinoma of the nasopharynx.
  • OBJECTIVE: A cisplatin-containing regimen followed by radiation therapy is the recommended treatment for patients with advanced nasopharyngeal carcinoma.
  • We report a case of a 58-year-old woman with hemolytic-uremic syndrome (HUS) who received induction chemotherapy for undifferentiated squamous cell carcinoma of the nasopharynx.
  • PATIENTS AND METHODS: During the 2nd course of chemotherapy (consisting of bleomycin, cisplatin and epirubicin), the patient developed hemolytic anemia, thrombocytopenia, and acute renal failure.
  • RESULTS: Twice daily therapeutic plasma exchange (TPE) with fresh-frozen plasma, hemodialysis and high-dose cortisone was performed.
  • Six weeks after the administration of the second course of chemotherapy, the patient had fully recovered from HUS, and radiation therapy was carried out as planned.
  • The patient responded well to treatment, but died 9 months after the diagnosis due to liver metastases.
  • CONCLUSION: We demonstrated that early TPE with fresh-frozen plasma and high-dose cortisone is a potentially successful treatment modality for the usually fatal, fulminant form of chemotherapy-induced HUS.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Cisplatin / adverse effects. Hemolytic-Uremic Syndrome / chemically induced. Nasopharyngeal Neoplasms / drug therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Chemotherapy, Adjuvant / adverse effects. Combined Modality Therapy. Cortisone / therapeutic use. Epirubicin / administration & dosage. Fatal Outcome. Female. Humans. Middle Aged. Plasma. Plasma Exchange. Renal Dialysis

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  • [Copyright] Copyright 2001 S. Karger AG, Basel
  • (PMID = 11528253.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 3Z8479ZZ5X / Epirubicin; Q20Q21Q62J / Cisplatin; V27W9254FZ / Cortisone
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4. Cheng JC, Esparza SD, Knez VM, Sakamoto KM, Moore TB: Severe lactic acidosis in a 14-year-old female with metastatic undifferentiated carcinoma of unknown primary. J Pediatr Hematol Oncol; 2004 Nov;26(11):780-2
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  • [Title] Severe lactic acidosis in a 14-year-old female with metastatic undifferentiated carcinoma of unknown primary.
  • The diagnosis of an undifferentiated carcinoma of unknown primary was made after open breast biopsy of the mass with negative immunohistochemical studies for breast malignancies.
  • Further evaluation showed extensive metastatic disease affecting the bone marrow, ribs, liver, and brain with magnetic resonance imaging evidence of carcinomatous meningitis.
  • Despite 2 months of chemotherapy and intensive supportive care, the patient died of severe lactic acidosis and disseminated intravascular coagulation after exaggerated menstrual bleeding.
  • The association of severe lactic acidosis and undifferentiated carcinoma of unknown primary in an adolescent has not been previously described.
  • [MeSH-major] Acidosis, Lactic / etiology. Carcinoma / complications. Carcinoma / pathology
  • [MeSH-minor] Adolescent. Breast Neoplasms / pathology. Disseminated Intravascular Coagulation / etiology. Fatal Outcome. Female. Hemorrhage / etiology. Humans. Neoplasm Metastasis / diagnosis. Neoplasm Metastasis / pathology

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  • (PMID = 15543020.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Silva EG, Deavers MT, Bodurka DC, Malpica A: Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma? Int J Gynecol Pathol; 2006 Jan;25(1):52-8
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  • [Title] Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma?
  • The association of this type of tumor with undifferentiated carcinoma is rare.
  • The endometrioid carcinoma involved the endometrium in 14 cases, the endometrium and 1 or both ovaries in 9 cases, and the ovaries in 2 cases.
  • Undifferentiated carcinoma associated with low-grade endometrioid carcinoma was found at presentation in 19 grade 1 or 2 endometrioid carcinomas: 15 in the endometrium and 5 in the ovary.
  • In one of these cases, undifferentiated carcinoma was found in the endometrium and the ovary.
  • Undifferentiated carcinoma was found after resection of low-grade endometrioid carcinoma in six cases, involving the retroperitoneum, pelvis, vagina, or liver.
  • The undifferentiated carcinoma was composed exclusively of diffuse sheets and solid nests of epithelial cells in l0 cases.
  • Twenty-two patients received additional therapy as follows: chemotherapy (), radiotherapy (), and tamoxifen ().
  • In four cases, the diagnosis was made recently, with short follow-ups of 3 and 4 months.
  • Foci of undifferentiated carcinoma may be confused with solid endometrioid adenocarcinoma erroneously leading to the diagnosis of a grade 3 or a significantly less aggressive grade 2 endometrioid carcinoma.
  • The recognition of undifferentiated carcinoma in an otherwise low-grade endometrioid adenocarcinoma is extremely important because it indicates aggressive behavior.
  • In asynchronous cases, being aware of this association can explain the absence of a second primary.
  • [MeSH-major] Carcinoma, Endometrioid / pathology. Cell Transformation, Neoplastic. Endometrial Neoplasms / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Humans. Immunoenzyme Techniques. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Second Primary

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  • [ErratumIn] Int J Gynecol Pathol. 2006 Jul;25(3):304
  • (PMID = 16306785.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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6. Scherwitz P, Lindenfelser R, Krüger I: [Localization of primary small cell carcinoma with liver metastasis: a rare combination of colonic adenocarcinoma and undifferentiated small cell carcinoma]. Chirurg; 2002 Aug;73(8):859-61
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  • [Title] [Localization of primary small cell carcinoma with liver metastasis: a rare combination of colonic adenocarcinoma and undifferentiated small cell carcinoma].
  • We present a case of a 67-year-old female patient with liver metastasis of SCC.
  • Initially, the primary tumor was not found and the patient underwent chemotherapy.
  • Microscopic examination revealed that the adenocarcinoma was combined with an undifferentiated carcinomatous component.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Small Cell / secondary. Colonic Neoplasms / diagnosis. Liver Neoplasms / secondary. Neoplasms, Multiple Primary. Neoplasms, Unknown Primary. Paclitaxel / analogs & derivatives. Taxoids
  • [MeSH-minor] Aged. Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Colectomy. Colon / pathology. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Immunohistochemistry. Liver / pathology. Time Factors. Vincristine / administration & dosage

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  • (PMID = 12425166.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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7. Kanoh T, Ohnishi T, Tono T, Takemoto H, Shiozaki K, Kimura Y, Iwazawa T, Nakano Y, Yano H, Monden T: [A case of successfully treated unresectable multiple liver metastases from colon cancer by hepatic arterial infusion chemotherapy and systemic chemotherapy]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1953-5
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  • [Title] [A case of successfully treated unresectable multiple liver metastases from colon cancer by hepatic arterial infusion chemotherapy and systemic chemotherapy].
  • Sigmoidectomy was performed for a 69-year-old man with sigmoid colon cancer and unresectable multiple liver metastases.
  • The histological diagnosis was undifferentiated carcinoma of sigmoid colon.
  • Hepatic arterial infusion chemotherapy with 5 FU and systemic chemotherapy with CPT-11 were performed after the operation.
  • A complete response (CR) was achieved for liver metastases.
  • This combination therapy is expected to be an alternative treatment of colorectal cancer with unresectable multiple liver metastases.
  • [MeSH-major] Camptothecin / analogs & derivatives. Carcinoma / pathology. Fluorouracil / administration & dosage. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Sigmoid Neoplasms / pathology

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  • (PMID = 17212157.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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8. Ho CL, Lee SH, Chen LM, Chao TY: Epstein-Barr virus early ribonucleic acids as a diagnostic adjunct for relapsed metastatic tumors in patients with cured primary undifferentiated nasopharyngeal carcinoma. Am J Otolaryngol; 2000 Mar-Apr;21(2):80-4
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  • [Title] Epstein-Barr virus early ribonucleic acids as a diagnostic adjunct for relapsed metastatic tumors in patients with cured primary undifferentiated nasopharyngeal carcinoma.
  • PURPOSE: Epstein-Barr virus (EBV) has been consistently shown to be associated with undifferentiated nasopharyngeal carcinoma (NPC).
  • In this article, the authors attempt to detect Epstein-Barr virus in distant relapsed metastatic sites in undifferentiated NPC patients with cured primary cancer.
  • We used a nonisotopical ISH technique to examine the presence of EBERs in paraffin-embedded tissues obtained from 1 paired specimen of primary NPC and its metastatic counterpart at liver and 2 metastatic specimens of retroperitoneal lymph nodes and bone.
  • RESULTS: All the primary lesions and the metastatic tumors of NPC with undifferentiated histology contained EBERs that could be clearly detected in the nuclei of cancer cells.
  • These results suggest that this nonisotopical ISH method of EBERs can be potentially used to diagnose NPC patients developing distant relapsed metastatic lesions with cured primary cancer early.
  • It can offer quick information as to institute suitable salvage chemotherapy for these patients.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / diagnosis. Carcinoma / secondary. Herpesvirus 4, Human / isolation & purification. Nasopharyngeal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / virology
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Bone Neoplasms / diagnosis. Bone Neoplasms / secondary. Bone Neoplasms / therapy. Bone Neoplasms / virology. Female. Humans. In Situ Hybridization. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Liver Neoplasms / virology. Lymphatic Metastasis. Male. RNA, Viral / analysis. Sensitivity and Specificity

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  • (PMID = 10758991.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Viral
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9. Foltys D, Linkermann A, Heumann A, Hoppe-Lotichius M, Heise M, Schad A, Schneider J, Bender K, Schmid M, Mauer D, Peixoto N, Otto G: Organ recipients suffering from undifferentiated neuroendocrine small-cell carcinoma of donor origin: a case report. Transplant Proc; 2009 Jul-Aug;41(6):2639-42
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  • [Title] Organ recipients suffering from undifferentiated neuroendocrine small-cell carcinoma of donor origin: a case report.
  • Undifferentiated neuroendocrine small-cell carcinoma is an aggressive tumor with the tendency to spread.
  • The recipient of the liver graft presented with suspected nodules on routine abdominal ultrasound.
  • After computed tomography (CT) scan, biopsy confirmed the diagnosis of a small-cell carcinoma.
  • Despite chemotherapy the patient died 7 months after orthotopic liver transplantation (OLT).
  • All involved transplantation centers were informed immediately following diagnosis.
  • One year after transplantation, liver metastases caused by a histologically proven small-cell carcinoma from the same donor were apparent.
  • Chemotherapy was immediately started and the graft was removed.
  • Despite continued treatment the tumor progressed and the patient died after repeated intestinal complications.
  • CONCLUSION: Therapeutic regimens in recipients suffering from donor-derived carcinoma differ depending on the transplanted organ.
  • Graft removal of non-life-sustaining organs and discontinuation of immunosuppressive medication should result in complete tumor rejection.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Carcinoma, Small Cell / pathology. Embolization, Therapeutic / methods. Liver Neoplasms / surgery. Liver Transplantation / methods. Tissue Donors. alpha 1-Antitrypsin Deficiency / surgery
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Carboplatin / therapeutic use. DNA Fingerprinting. Etoposide / therapeutic use. Heart Transplantation / immunology. Heart Transplantation / pathology. Humans. Immunosuppressive Agents / therapeutic use. Kidney Transplantation / immunology. Kidney Transplantation / pathology. Male. Middle Aged. Neoplasm Metastasis / genetics. Neoplasm Metastasis / pathology. Nephrectomy


10. Yamamoto R, Hosokawa S, Yamatodani T, Morita S, Okamura J, Mineta H: [Eight cases of neuroendcrine carcinoma of the head and neck]. Nihon Jibiinkoka Gakkai Kaiho; 2008 Jul;111(7):517-22
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  • [Title] [Eight cases of neuroendcrine carcinoma of the head and neck].
  • Small cell neuroendocrine carcinoma of the head and neck is rare, and diagnosis may be difficult.
  • We reported eight cases of stage IV small cell neuroendocrine carcinoma of the head and neck, all in men with a mean onset age of 62 years (range: 45 to 80 years).
  • Histological analysis by hematoxylin-eosin staining tentatively revealed malignant lymphoma and undifferentiated carcinoma in two cases each, while immunohistological and/or electron microscopy analysis confirmed histological diagnosis.
  • All were treated by chemotherapy (VP-16, CDDP) and seven cases with radiotherapy based on the schedule of small cell carcinoma of the lung and two cases with lesional resection.
  • Chemotherapy and radiotherapy were effective locally.
  • Five patients died of distant metastasis to the brain, bone, lung, liver, or skin within 12 months.
  • One is alive with liver metastasis.
  • Long-term survival thus requires the effective treatment of distant metastasis.
  • [MeSH-major] Carcinoma, Neuroendocrine / pathology. Carcinoma, Neuroendocrine / therapy. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Cisplatin / administration & dosage. Combined Modality Therapy. Diagnosis, Differential. Epirubicin / administration & dosage. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy

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  • (PMID = 18697475.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 3Z8479ZZ5X / Epirubicin; Q20Q21Q62J / Cisplatin; PE regimen
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11. Rosito P, Mancini AF, Semeraro M, Paone G, Lima M, Federici S, Domini M, Burnelli R, Baroncini S, Gentili A, Paolucci G, Domini R: [Malignant primary tumors of the liver in childhood]. Pediatr Med Chir; 2002 May-Jun;24(3):200-7
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  • [Title] [Malignant primary tumors of the liver in childhood].
  • Twenty-one children (16 males, 5 females) with malignant primary hepatic tumors were admitted to the Pediatric Clinic of the University of Bologna between June 1973 and July 2001.
  • The diagnosis was hepatoblastoma (HBL) in 16 cases; hepatocellular carcinoma (HCA) in 3 cases; undifferentiated sarcoma in 1, malignant rhabdoid tumour of the liver in 1.
  • Median age at diagnosis was 1.8 year (1 mounth-13 years).
  • At diagnosis 3 pts presented lung metastases.
  • In 10 patients, initially with unresesectable tumor, chemotherapy was started first.
  • Drugs used were mostly Cisplatinum or Carboplatinum with Doxorubicin.
  • We conclude that excluding metastases at diagnosis (3 deaths), the main prognostic factor is resectability and radical surgery: in our experience 4 patients with unresectable tumor died, as 2 patients with microscopical residual after surgery.
  • [MeSH-major] Liver Neoplasms / epidemiology
  • [MeSH-minor] Algorithms. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Retrospective Studies

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  • (PMID = 12236033.001).
  • [ISSN] 0391-5387
  • [Journal-full-title] La Pediatria medica e chirurgica : Medical and surgical pediatrics
  • [ISO-abbreviation] Pediatr Med Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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12. Lau JS, Yeo W, Chan YL, Chan W, Hui P, Leung SF, Kwan WK, Chan AT: Intracranial metastasis from nasopharyngeal carcinoma: Report of three cases and review of literature. J Clin Oncol; 2004 Jul 15;22(14_suppl):5608

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  • [Title] Intracranial metastasis from nasopharyngeal carcinoma: Report of three cases and review of literature.
  • : 5608 Background: Brain metastasis (mets) from nasopharyngeal carcinoma (NPC) is a controversial entity.
  • All 3 patients received whole brain radiation therapy (WBRT) for the brain mets.
  • Static disease was achieved with chemotherapy.
  • Histology of the lesion revealed metastatic undifferentiated carcinoma, staining positive for Epstein-Barr virus-encoded RNA (EBER).
  • He received WBRT and remained alive at the most recent follow-up, which was 1 year after the diagnosis of brain mets.
  • At 32 months follow-up he was found to have mets in the lungs, liver and bone.
  • Partial response was achieved with chemotherapy.
  • Biopsy confirmed undifferentiated carcinoma consistent with mets of NPC.

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  • (PMID = 28015287.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Almogy G, Lieberman S, Gips M, Pappo O, Edden Y, Jurim O, Simon Slasky B, Uzieli B, Eid A: Clinical outcomes of surgical resections for primary liver sarcoma in adults: results from a single centre. Eur J Surg Oncol; 2004 May;30(4):421-7
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  • [Title] Clinical outcomes of surgical resections for primary liver sarcoma in adults: results from a single centre.
  • BACKGROUND: Primary hepatic sarcoma is a rare tumour with a poor prognosis.
  • METHODS: From 1997 to 2002 eight patients had liver resection for primary sarcoma of the liver at our institution.
  • The clinical characteristics, imaging findings, surgical procedures, adjuvant therapy and outcome were retrospectively reviewed.
  • There were two patients each with angiosarcoma (AS), leiomyosarcoma (LMS), and undifferentiated embryonal sarcoma (UES), one patient with epithelioid hemangioendothelioma (EHE) and one patient with malignant peripheral nerve sheath sarcoma (PNSS).
  • Preoperative diagnosis of a primary liver sarcoma was made in 7/8 cases, either by fine needle aspiration (n = 5) or angiography (n = 2).
  • Two patients developed complications and there was one death.
  • Systemic chemotherapy led to tumour regression in both patients with UES which enabled a second hepatic resection.
  • CONCLUSIONS: The majority of patients with primary liver sarcoma present with right upper quadrant pain, fever and a liver mass.
  • Differentiating the rare primary liver sarcoma from the much more common hepatocellular carcinoma (HCC) may aid in planning therapy.
  • Liver resection combined with adjuvant chemotherapy are the mainstays of treatment for UES in the adult.
  • [MeSH-major] Liver Neoplasms / surgery. Sarcoma / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Diagnosis, Differential. Female. Hepatectomy / methods. Humans. Length of Stay. Liver Function Tests. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15063896.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Wada Y, Yamamoto T, Kita Y, Fukunishi S, Ashida K: [An autopsy case of encephalopathy associated with small cell carcinoma of the stomach with nonconvulsive status epilepticus resembling Creutzfeldt-Jakob disease]. No To Shinkei; 2003 May;55(5):423-8
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  • [Title] [An autopsy case of encephalopathy associated with small cell carcinoma of the stomach with nonconvulsive status epilepticus resembling Creutzfeldt-Jakob disease].
  • A 64-year-old man developed progressive dementia and altered consciousness with myoclonus over 2 months.
  • Since his consciousness level fluctuated and the PSD were spiky, we came to a diagnosis of nonconvulsive status epilepticus (NCSE).
  • Biopsy of the periaortic lymph node by laparotomy revealed undifferentiated adenocarcinoma with its origin being unclear.
  • Chemotherapy didn't work well for the tumor and the patient underwent a downhill course, although his mental and neurological manifestation were mostly unremarkable.
  • Autopsy confirmed small cell carcinoma originating in the stomach and metastases in the liver and lungs.
  • [MeSH-major] Brain Diseases / pathology. Carcinoma, Small Cell / complications. Creutzfeldt-Jakob Syndrome / diagnosis. Status Epilepticus / diagnosis. Stomach Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging. Electroencephalography. Humans. Male


15. Hu Y, Lu T, Mai W, Han F, Huang Y, Liu H, Zhang E: [Important prognostic factors in patients with skull base erosion from nasopharyngeal carcinoma after radiotherapy]. Zhonghua Er Bi Yan Hou Ke Za Zhi; 2001 Dec;36(6):463-7
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  • [Title] [Important prognostic factors in patients with skull base erosion from nasopharyngeal carcinoma after radiotherapy].
  • OBJECTIVE: To evaluate the long-term outcome and prognostic factors in patients with skull base erosion from nasopharyngeal carcinoma (NPC) after initial radiation therapy.
  • METHODS: From January 1985 to December 1986, 100 patients (71 male, 29 female) with the diagnosis of NPC were found to have skull base erosion from computed tomography (CT).
  • Ninety-six patients had World Health Organization (WHO) type III undifferentiated carcinoma while four had type I carcinomas.
  • Metastatic workup including chest radiography, liver ultrasound and liver function test were negative.
  • All patients underwent external beam radiotherapy alone to 66-80 Gy over 6-8 weeks.
  • Daily fraction size of 2 Gy was delivered utilizing cobalt-60 or linear accelerator.
  • No patient received chemotherapy.
  • CONCLUSION: This report presents one of the longest follow-ups of patients with nasopharyngeal carcinoma invading skill base.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Nasopharyngeal Neoplasms / diagnosis. Skull Base Neoplasms / diagnosis

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  • (PMID = 12761966.001).
  • [ISSN] 0412-3948
  • [Journal-full-title] Zhonghua er bi yan hou ke za zhi
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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16. Lu TX, Mai WY, Teh BS, Hu YH, Lu HH, Chiu JK, Carpenter LS, Woo SY, Butler EB: Important prognostic factors in patients with skull base erosion from nasopharyngeal carcinoma after radiotherapy. Int J Radiat Oncol Biol Phys; 2001 Nov 1;51(3):589-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Important prognostic factors in patients with skull base erosion from nasopharyngeal carcinoma after radiotherapy.
  • PURPOSE: To evaluate the long-term outcome and prognostic factors in patients with skull base erosion from nasopharyngeal carcinoma after initial radiotherapy (RT).
  • METHODS AND MATERIALS: From January 1985 to December 1986, 100 patients (71 males, 29 females) with a diagnosis of nasopharyngeal carcinoma were found on computed tomography (CT) to have skull base erosion.
  • Ninety-six patients had World Health Organization type III undifferentiated carcinoma, and 4 had type I.
  • The metastatic workup, including chest radiography, liver ultrasound scanning, and liver function test was negative.
  • All patients underwent external beam RT (EBRT) alone to 66-80 Gy during 6-8 weeks.
  • A daily fraction size of 2 Gy was delivered using 60Co or a linear accelerator.
  • No patient received chemotherapy.
  • A difference in the time course of local recurrence and distant metastasis was observed.
  • CONCLUSIONS: We present one of the longest follow-ups of patients with nasopharyngeal carcinoma invading the skull base.
  • [MeSH-minor] Adolescent. Adult. Aged. Analysis of Variance. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / mortality. Neoplasm Staging. Prognosis. Proportional Hazards Models. Skull Base / pathology. Time Factors

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  • (PMID = 11597797.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Czauderna P, Popadiuk S, Korzon M, Stoba C, Szymik-Kantorowicz S, Sawicz-Birkowska K, Lopatka B, Bogusławska-Jaworska J, Kowalczyk J, Sopyło B, Madziara W, Juszkiewicz P, Swiatkiewicz V, Skotnicka-Klonowicz G, Włodarczyk A: Multicenter retrospective analysis of various primary pediatric malignant hepatic tumors--management in a series of 47 Polish patients (1985-1995). Eur J Pediatr Surg; 2001 Apr;11(2):82-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multicenter retrospective analysis of various primary pediatric malignant hepatic tumors--management in a series of 47 Polish patients (1985-1995).
  • Forty-seven children treated in various Polish centers between 1985 and 1995 for primary malignant liver tumors were retrospectively analyzed.
  • There were 6 hepatocarcinoma (HCC) cases and 2 cases of undifferentiated sarcoma (UDS).
  • In 44% of HB patients the tumor involved both liver lobes.
  • 18% of children with HB presented with pulmonary metastases at diagnosis.
  • Chemotherapy was applied in 92% of cases (preoperatively in 67%).
  • Overall survival of patients with hepatoblastoma was 43.6%, while it was 50% for hepatocarcinoma and 100% for undifferentiated sarcoma (2 cases only).
  • Mean observation time was 58 months.
  • Involvement of both lobes of the liver and multifocality of the tumor were other adverse prognostic factors.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hepatoblastoma / surgery. Liver Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / surgery
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Male. Poland / epidemiology. Retrospective Studies. Survival Rate

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  • (PMID = 11371041.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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18. Parker LP, Duong JL, Wharton JT, Malpica A, Silva EG, Deavers MT: Desmoplastic small round cell tumor: report of a case presenting as a primary ovarian neoplasm. Eur J Gynaecol Oncol; 2002;23(3):199-202
Hazardous Substances Data Bank. TAXOL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoplastic small round cell tumor: report of a case presenting as a primary ovarian neoplasm.
  • BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is an intra-abdominal malignancy that typically has extensive peritoneal spread at the time of diagnosis.
  • During tumor reductive surgery the right ovary, omentum, and liver were found to be involved.
  • Initial histologic examination favored an undifferentiated small cell carcinoma of the ovary.
  • The patient received two cycles of Taxol and cisplatin chemotherapy and was referred to the University of Texas M. D.
  • Upon review of the pathology material at the time of the referral, a diagnosis of DSRCT was made.
  • Despite two additional cycles of chemotherapy, the tumor progressed, and the patient returned home.
  • CONCLUSION: DSRCT may mimic an ovarian primary tumor by presenting with involvement of the ovary and an elevated CA-125 level, and should be included in the differential diagnosis of ovarian neoplasms in young patients.
  • [MeSH-major] Carcinoma, Small Cell / diagnosis. Liver Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. CA-125 Antigen / blood. Cisplatin / administration & dosage. Diagnosis, Differential. Female. Humans. Omentum / pathology. Paclitaxel / administration & dosage


19. Petraki C, Vaslamatzis M, Petraki K, Revelos K, Alevizopoulos N, Papanastasiou P, Gregorakis A: Prostate cancer with small-cell morphology: an immunophenotypic subdivision. Scand J Urol Nephrol; 2005;39(6):455-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To study the immunophenotypic characteristics and clinical outcome of morphologically undifferentiated prostatic carcinoma with small-cell morphology (U-PC-SCM).
  • The streptavidin-biotin complex immunohistochemical method was used on paraffin-embedded tissue sections to test positivity for prostate-specific antigen, prostate-specific acid phosphatase, CD57, androgen receptors, CK8-18, epithelial membrane antigen, carcinoembryonic antigen, CD56, neuron-specific enolase, chromogranin, synaptophysin, serotonin, various hormones, thyroid transcriptional factor-1 and Ki-67/MIB1.
  • The final diagnosis was U-PC (Gleason score 10) in Group 1 (n=9) and pure or mixed neuroendocrine small-cell carcinoma in Group 2 (n=7).
  • The third patient showed a partial response (PR) for 18 months but eventually relapsed with liver metastatic lesions.
  • He was then treated with cisplatin + etoposide and showed a PR for 3 months and survived for 5 months after the initiation of the second-line chemotherapy (CTH) treatment.
  • [MeSH-major] Biomarkers, Tumor / immunology. Carcinoma, Small Cell / immunology. Immunophenotyping. Prostatic Neoplasms / immunology

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  • (PMID = 16303720.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen
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20. Kakudo Y, Yoshioka T, Noguchi S, Hanada M, Otsuka K, Sakayori M, Chiba N, Shibata H, Kato S, Shimodaira H, Ohori H, Takahashi S, Takahashi M, Yamaura G, Yasuda K, Ishioka C: [A case of malignant melanoma from the esophagus responding to weekly paclitaxel therapy]. Gan To Kagaku Ryoho; 2006 Jul;33(7):969-72
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  • [Title] [A case of malignant melanoma from the esophagus responding to weekly paclitaxel therapy].
  • A 44-year-old man had a tumor in the lower thoracic esophagus at a health check, and was initially diagnosed as an undifferentiated carcinoma of the esophagus by the esophago-gastric endoscope.
  • Although curative chemoradiotherapy was scheduled after the diagnosis, the interim evaluation revealed that the tumor was malignant melanoma of the esophagus with right renal metastasis.
  • Since then, CVD (cisplatin, vindesine and dacarbazine) therapy, palliative radiotherapy and DAC-Tam (dacarbazine, nimustine, cisplatin and tamoxifen) therapy were carried out, but all of them proved ineffective, and multiple newly metastatic lesions appeared in liver and lymph nodes.
  • As a fourth-line therapy, weekly paclitaxel therapy was started, and his oral intake was improved after the second course.
  • He received the therapy as an outpatient for four months.
  • Consequently, five courses of the therapy were performed with modest adverse effects.
  • Weekly paclitaxel therapy was reasonably safe as reported in other reports and considered to be a promising regimen for malignant melanoma of the esophagus.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / administration & dosage. Esophageal Neoplasms / drug therapy. Melanoma / drug therapy. Paclitaxel / administration & dosage
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Drug Administration Schedule. Humans. Kidney Neoplasms / drug therapy. Kidney Neoplasms / radiotherapy. Kidney Neoplasms / secondary. Liver Neoplasms / drug therapy. Liver Neoplasms / radiotherapy. Liver Neoplasms / secondary. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Quality of Life

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  • (PMID = 16835489.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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21. Rickman T, Garmany R, Doherty T, Benson D, Okusa MD: Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. Am J Kidney Dis; 2001 Apr;37(4):838-46
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  • We report a 69-year-old white man with a history of high-grade prostate carcinoma and widely metastatic adenocarcinoma who presented with metabolic alkalosis, hypokalemia, and hypertension secondary to ectopic ACTH and CRH secretion.
  • Abdominal CT scan and magnetic resonance imaging showed multiple small liver lesions and multiple thoracic and lumbar intensities consistent with diffuse metastatic disease.
  • Histological analysis of a biopsy specimen from the thoracic spine showed an undifferentiated adenocarcinoma consistent with a prostate primary tumor.
  • In this case report, we describe an unusual tumor associated with ectopic ACTH and CRH production and the pharmacodynamic relationship of plasma cortisol levels and urinary cortisol excretion with ketoconazole treatment.
  • [MeSH-major] Adenocarcinoma / secondary. Alkalosis / diagnosis. Cushing Syndrome / diagnosis. Hypertension / diagnosis. Hypokalemia / diagnosis. Prostatic Neoplasms / secondary
  • [MeSH-minor] ACTH Syndrome, Ectopic / diagnosis. ACTH Syndrome, Ectopic / drug therapy. ACTH Syndrome, Ectopic / epidemiology. Adrenocorticotropic Hormone / blood. Aged. Comorbidity. Corticotropin-Releasing Hormone / blood. Corticotropin-Releasing Hormone / secretion. Humans. Hydrocortisone / blood. Ketoconazole / therapeutic use. Male. Neoplasm Metastasis / diagnosis. Paraneoplastic Endocrine Syndromes / diagnosis. Paraneoplastic Endocrine Syndromes / epidemiology. Tomography, X-Ray Computed


22. Torrejón Reyes PN, Frisancho O, Gómez A, Yábar A: [Malignant peritoneal mesothelioma]. Rev Gastroenterol Peru; 2010 Jan-Mar;30(1):82-7
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  • The peritoneal mesothelioma is a rare pathology with unspecific symptoms reason to be a difficult diagnosis.
  • We report a case of a 58 year old man with diabetes mellitus type 2, arterial hypertension and smoking; without precedent of asbestos exposure.
  • The abdomen distended by ascites, not painful, liver and spleen not examined.
  • Cytology: mesothelial cells with changes of type reagent, Block cell for tumour cells: negative.
  • The report of the peritoneal biopsy was informed as suggestive of undifferentiated carcinoma; the reappraisal with inmunohystochemic (calretinin +,cytokeratin +, vimentin +) indicated malignant peritoneal mesothelioma, type epithelial.
  • The patient was transferred to the Service of Oncology where they initiated chemotherapy with Cysplatin (CDDP) and died 20 days later.
  • The malignant mesothelioma peritoneal is a unfrequent entity, with limited therapeutic options; generally detected late, with a palliative treatment.

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  • (PMID = 20445731.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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