[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Item 1 of about 1
1. Gollnick H: Current concepts of the pathogenesis of acne: implications for drug treatment. Drugs; 2003;63(15):1579-96
Hazardous Substances Data Bank. BENZOYL PEROXIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current concepts of the pathogenesis of acne: implications for drug treatment.
  • The pathogenesis of acne is complex, with strong evidence supporting the involvement of sebaceous hyperplasia, follicular hyperkeratinisation, bacterial hypercolonisation, as well as immune reactions and inflammation.
  • This leads to further increased production of the pro-inflammatory cytokines interleukin-1alpha and tumour necrosis factor alpha by T cells and keratinocytes, leading to proliferation of both cell types.
  • Follicular keratinocytes fail to differentiate by apoptosis and produce hypergranulosis similar to the impermeable skin outer layer, resulting in the formation of microcomedones.
  • Retinoids aid the differentiation and reduce the hyperproliferation of keratinocytes, and can inhibit the migration of leucocytes.
  • Combination therapy using retinoids plus benzoyl peroxide or antibacterials can treat existing acne lesions faster than the individual agents alone and can also prevent the development of new lesions.
  • When added to antibacterial therapy, topical retinoids demonstrate faster and significantly greater reduction of inflammatory acne lesions and comedones than antibacterials alone.
  • [MeSH-major] Acne Vulgaris / drug therapy. Acne Vulgaris / etiology. Anti-Bacterial Agents / therapeutic use. Benzoyl Peroxide / therapeutic use. Retinoids / therapeutic use
  • [MeSH-minor] Administration, Oral. Administration, Topical. Androgens / metabolism. Dermatitis / drug therapy. Dermatitis / metabolism. Dermatitis / microbiology. Drug Therapy, Combination. Epithelial Cells / metabolism. Epithelial Cells / microbiology. Epithelial Cells / pathology. Gram-Positive Bacterial Infections / drug therapy. Humans. Linoleic Acid / deficiency. Propionibacterium acnes / drug effects. Propionibacterium acnes / pathogenicity. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Sebum / metabolism

  • MedlinePlus Health Information. consumer health - Acne.
  • MedlinePlus Health Information. consumer health - Antibiotics.
  • Hazardous Substances Data Bank. LINOLEIC ACID .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Dermatology. 1998;196(1):93-4 [9557238.001]
  • [Cites] Biochem Cell Biol. 1998;76(6):889-98 [10392703.001]
  • [Cites] J Dermatol. 1991 Sep;18(9):489-99 [1838558.001]
  • [Cites] Br J Dermatol. 2000 Jun;142(6):1084-91 [10848729.001]
  • [Cites] Dermatology. 1998;196(1):38-42 [9557222.001]
  • [Cites] Br J Dermatol. 1976 Jun;94(6):633-7 [132960.001]
  • [Cites] J Invest Dermatol. 1989 Apr;92(4):593-7 [2649596.001]
  • [Cites] Arch Dermatol Res. 1996 Oct;288(11):703-8 [8931874.001]
  • [Cites] Exp Dermatol. 1994 Aug;3(4):151-60 [8000703.001]
  • [Cites] J Dermatol. 2000 May;27(5):318-23 [10875198.001]
  • [Cites] Dermatology. 1998;196(1):75-9 [9557233.001]
  • [Cites] J Invest Dermatol. 1999 Dec;113(6):1011-20 [10594745.001]
  • [Cites] J Invest Dermatol. 1999 Feb;112(2):157-64 [9989790.001]
  • [Cites] J Invest Dermatol. 1988 Dec;91(6):566-71 [2461419.001]
  • [Cites] Dermatologica. 1987;175(1):5-9 [2956135.001]
  • [Cites] J Invest Dermatol. 1992 Oct;99(4):509-11 [1402009.001]
  • [Cites] Semin Dermatol. 1992 Jun;11(2):100-5 [1498012.001]
  • [Cites] Dermatology. 1998;196(1):21-31 [9557220.001]
  • [Cites] Br J Dermatol. 1992 Dec;127(6):585-8 [1476918.001]
  • [Cites] J Cell Sci. 1995 Aug;108 ( Pt 8):2741-6 [7593315.001]
  • [Cites] Acta Derm Venereol Suppl (Stockh). 1975 Jan 27-29;74:111-5 [130772.001]
  • [Cites] Dermatology. 1994;189(4):344-9 [7873817.001]
  • [Cites] Dermatol Nurs. 1999 Jun;11(3):205-8 [10670337.001]
  • [Cites] Clin Exp Dermatol. 1998 Mar;23(2):56-8 [9692305.001]
  • [Cites] J Invest Dermatol. 1996 Jan;106(1):176-82 [8592071.001]
  • [Cites] Am J Clin Nutr. 2000 Jan;71(1 Suppl):361S-6S [10617998.001]
  • [Cites] J Invest Dermatol. 1990 Nov;95(5 Suppl):44S-46S [16788631.001]
  • [Cites] Exp Cell Res. 1993 Nov;209(1):118-22 [8223996.001]
  • [Cites] Dermatology. 1998;196(1):53-4 [9557226.001]
  • [Cites] J Invest Dermatol. 1998 Apr;110(4):410-5 [9540984.001]
  • [Cites] Cutis. 1996 Jan;57(1 Suppl):13-9 [8654127.001]
  • [Cites] Br J Dermatol. 1979 Sep;101(3):315-20 [159713.001]
  • [Cites] Br J Dermatol. 1998 Oct;139 Suppl 52:26-33 [9990418.001]
  • [Cites] Dermatology. 1998;196(1):98-9 [9557240.001]
  • [Cites] J Am Acad Dermatol. 1997 Nov;37(5 Pt 1):746-54 [9366821.001]
  • [Cites] Cutis. 2001 Jun;67(6 Suppl):4-9 [11499329.001]
  • [Cites] Clin Exp Dermatol. 1994 Jul;19(4):303-8 [7955470.001]
  • [Cites] Infect Immun. 1995 Aug;63(8):3158-65 [7542639.001]
  • [Cites] Dermatology. 1998;196(1):86-8 [9557236.001]
  • [Cites] Dermatology. 1998;196(1):9-15 [9557218.001]
  • [Cites] Br J Dermatol. 1980 Dec;103(6):651-5 [6450605.001]
  • [Cites] Dermatology. 1998;196(1):43-6 [9557223.001]
  • [Cites] Pediatr Dermatol. 1997 Nov-Dec;14(6):480-8 [9436851.001]
  • [Cites] Gynecol Obstet Invest. 1986;22(4):206-11 [2950033.001]
  • [Cites] Aust Fam Physician. 1999 May;28(5):447-51 [10376368.001]
  • [Cites] Inflammation. 1980 Sep;4(3):261-9 [7429606.001]
  • [Cites] J Invest Dermatol. 1999 Feb;112(2):226-32 [9989800.001]
  • [Cites] J Immunol. 1986 May 1;136(9):3317-23 [3007615.001]
  • [Cites] J Invest Dermatol. 1974 Mar;62(3):308-20 [4274208.001]
  • [Cites] Dermatology. 1998;196(1):51-2 [9557225.001]
  • [Cites] Cutis. 2002 Feb;69(2 Suppl):12-9 [12095064.001]
  • [Cites] Br J Dermatol. 1998 Oct;139 Suppl 52:48-56 [9990421.001]
  • [Cites] Dermatology. 1998;196(1):80-1 [9557234.001]
  • [Cites] Postgrad Med J. 1999 Jun;75(884):328-31 [10435165.001]
  • [Cites] Br J Dermatol. 1978 Jul;99(1):43-7 [150284.001]
  • [Cites] J Oral Maxillofac Surg. 1998 May;56(5):651-5 [9590347.001]
  • [Cites] J Am Acad Dermatol. 1986 Feb;14(2 Pt 1):221-5 [2936775.001]
  • [Cites] Br J Dermatol. 1994 Jun;130(6):731-7 [8011498.001]
  • [Cites] Adolesc Med. 1990 Jun;1(2):301-314 [10350714.001]
  • [Cites] J Invest Dermatol. 1975 Oct;65(4):379-81 [1176788.001]
  • [Cites] Infect Immun. 1979 Oct;26(1):183-6 [159261.001]
  • [Cites] J Invest Dermatol. 1992 Jun;98(6):895-901 [1534342.001]
  • [Cites] Br J Dermatol. 1986 Sep;115(3):386 [2944538.001]
  • [Cites] Br J Dermatol. 1987 Aug;117(2):175-83 [2958076.001]
  • [Cites] Dermatology. 1998;196(1):55-8 [9557227.001]
  • [Cites] Dermatology. 1998;196(1):32-7 [9557221.001]
  • [Cites] Horm Res. 2000;54(5-6):269-74 [11595816.001]
  • [Cites] Crit Rev Oral Biol Med. 1995;6(4):284-301 [8664420.001]
  • [Cites] J Invest Dermatol. 1974 Mar;62(3):288-307 [4361988.001]
  • [Cites] Br J Dermatol. 1997 Aug;137(2):246-50 [9292074.001]
  • [Cites] J Eur Acad Dermatol Venereol. 1998 Sep;11 Suppl 1:S8-12; discussion S28-9 [9891903.001]
  • [Cites] Lancet. 1999 Aug 28;354(9180):739-40 [10475188.001]
  • [Cites] Br J Dermatol. 1997 May;136(5):730-3 [9205507.001]
  • [Cites] Int J Dermatol. 1983 Jan-Feb;22(1):41-3 [6219964.001]
  • [Cites] J Eur Acad Dermatol Venereol. 2001;15 Suppl 3:63-7 [11843237.001]
  • [Cites] Curr Pharm Des. 2000 Jun;6(9):919-31 [10828316.001]
  • [Cites] J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S110-2 [9204087.001]
  • [Cites] Endocr Rev. 2000 Aug;21(4):363-92 [10950157.001]
  • [Cites] Br J Dermatol. 1994 May;130(5):576-82 [7515637.001]
  • [Cites] Br J Dermatol. 1988 May;118(5):651-9 [2969256.001]
  • [Cites] Curr Probl Dermatol. 1995;22:91-7 [7587341.001]
  • [Cites] J Invest Dermatol. 1978 Nov;71(5):324-9 [152335.001]
  • [Cites] Br J Dermatol. 1998 Nov;139(5):846-50 [9892952.001]
  • [Cites] J Am Acad Dermatol. 1998 Aug;39(2 Pt 3):S34-7 [9703121.001]
  • [Cites] Dermatology. 1998;196(1):135-9 [9557248.001]
  • [Cites] Dermatology. 1998;196(1):148-52 [9557250.001]
  • [Cites] Acta Derm Venereol. 1998 Nov;78(6):451-6 [9833047.001]
  • [Cites] J Invest Dermatol. 1990 Apr;94(4):496-8 [2138202.001]
  • [Cites] Br J Dermatol. 1997 Feb;136(2):166-71 [9068725.001]
  • [Cites] J Clin Microbiol. 1980 Nov;12(5):672-5 [7276142.001]
  • [Cites] Arch Dermatol Res. 1982;274(3-4):267-75 [6219635.001]
  • [Cites] Br J Dermatol. 2001 Jul;145(1):19-27 [11453902.001]
  • [Cites] J Invest Dermatol. 1990 Sep;95(3):271-4 [2143521.001]
  • [Cites] Horm Res. 2000;54(5-6):230-42 [11595811.001]
  • [Cites] Arch Fam Med. 2000 Feb;9(2):179-87 [10693736.001]
  • [Cites] J Dermatol. 1998 Dec;25(12):793-802 [9990771.001]
  • [Cites] Int J Dermatol. 2000 Oct;39(10):784-8 [11095202.001]
  • [Cites] Int J Mol Med. 2000 Aug;6(2):217-21 [10891569.001]
  • [Cites] Dermatology. 1998;196(1):140-7 [9557249.001]
  • [Cites] J Appl Bacteriol. 1979 Dec;47(3):383-94 [541303.001]
  • [Cites] Arch Dermatol. 1998 Apr;134(4):454-8 [9554297.001]
  • [Cites] J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S104-9 [9204086.001]
  • [Cites] J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S113-5 [9204088.001]
  • [Cites] Dermatology. 1998;196(1):59-66 [9557228.001]
  • [Cites] Agents Actions. 1990 Jan;29(1-2):56-8 [2109510.001]
  • [Cites] J Am Acad Dermatol. 1996 Mar;34(3):482-5 [8609263.001]
  • [Cites] J Invest Dermatol. 1995 Aug;105(2):209-14 [7636302.001]
  • [Cites] Eur J Dermatol. 1999 Dec;9(8):621-3 [10586129.001]
  • [Cites] J Am Acad Dermatol. 1998 Aug;39(2 Pt 3):S38-44 [9703122.001]
  • [Cites] Dis Mon. 1999 Aug;45(8):301-30 [10481765.001]
  • [Cites] J Am Acad Dermatol. 2001 Nov;45(5):S143-9 [11606946.001]
  • [Cites] Cutis. 1976 Mar;17(3):585-90 [138552.001]
  • [Cites] Br J Dermatol. 1996 Feb;134(2):247-56 [8746337.001]
  • [Cites] Br J Dermatol. 1986 May;114(5):543-52 [2941050.001]
  • [Cites] J Invest Dermatol. 1994 Jan;102(1):89-92 [8288915.001]
  • (PMID = 12887264.001).
  • [ISSN] 0012-6667
  • [Journal-full-title] Drugs
  • [ISO-abbreviation] Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Androgens; 0 / Anti-Bacterial Agents; 0 / Retinoids; 9KJL21T0QJ / Linoleic Acid; W9WZN9A0GM / Benzoyl Peroxide
  • [Number-of-references] 126
  •  go-up   go-down


Advertisement





Advertisement