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1. Sampath P, Park MC, Huang D, Deville C, Cortez S, Chougule P: Esthesioneuroblastoma (olfactory neuroblastoma) with hemorrhage: an unusual presentation. Skull Base; 2006 Aug;16(3):169-73
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  • Esthesioneuroblastoma (olfactory neuroblastoma) is an uncommon neuroectodermal tumor.
  • Treatment options consist of surgical resection followed by radiation therapy for primary lesions and the addition of chemotherapy for advanced, recurrent, or metastatic lesions.
  • However, we report the highly unusual case of a patient with an esthesioneuroblastoma who presented with atypical symptoms of headaches, sinus congestion, and fatigue before acutely losing consciousness.
  • Imaging showed a large frontal skull-based tumor associated with intratumoral hemorrhage.
  • The findings prompted an emergent combined anterior craniofacial resection with gross total resection of the tumor.
  • Postoperatively, she received adjuvant intensity-modulated radiation therapy and chemotherapy.

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  • (PMID = 17268590.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1586171
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2. Cheng C, Long Xb: [Diagnosis and treatment of esthesioneuroblastoma in the nasal cavity and sinuses]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Oct;30(10):2402-3, 2405
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  • [Title] [Diagnosis and treatment of esthesioneuroblastoma in the nasal cavity and sinuses].
  • OBJECTIVE: To discuss the clinical characteristics, diagnosis and treatment of esthesioneuroblastoma (ENB).
  • METHODS: The clinical data of 7 patients with ENB were analyzed retrospectively, and the clinical characteristics, diagnosis, surgical approaches and prognosis of the disease were discussed.
  • RESULTS: The 7 patients received surgical treatment combined with radiotherapy and chemotherapy.
  • Tumor relapse occurred within one year in two cases, which were treated with a second operation combined with radiotherapy, and one patient died and one survived with tumor after a one-year follow-up.
  • CONCLUSION: Early diagnosis of ENB can be difficult.
  • Transnasal-frontal approach with nasal endoscope is effective approach to ENB treatment, and the patients may benefit from postoperative radiotherapy and chemotherapy to improve the prognosis.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory. Nose Neoplasms. Paranasal Sinus Neoplasms

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  • (PMID = 20965857.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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3. Uzuka T, Kakita A, Inenaga C, Takahashi H, Tanaka R, Takahashi H: Frontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course. Case report. Neurol Med Chir (Tokyo); 2007 Apr;47(4):174-7
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  • [Title] Frontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course. Case report.
  • Neuroimaging studies revealed a right frontal tumor.
  • Histological examinations of biopsy specimens revealed that the tumor was oligodendroglial in nature.
  • Total resection was repeated four times, and malignant change was evident within the tissues.
  • The final diagnosis was anaplastic oligodendroglioma.
  • Despite irradiation, combination chemotherapy, and interstitial hyperthermia, the tumor grew rapidly but was confined to the cavity created by previous removal operations.
  • At autopsy, generalized metastases from the tumor were identified at various sites, including the dura mater covering the frontal lobes and thoracic cord, cavernous sinus, tuberculum sellae, spleen, liver, pancreas, lungs, paratracheal lymph nodes, vertebral bodies, ribs, sternum, pelvis, dorsal root ganglia, and iliopsoas muscle.
  • This rare case of cerebral anaplastic oligodendroglioma developed in adolescence, and rapid hematogenous spread of the glioma cells into the systemic organs occurred after a relatively long clinical course.
  • [MeSH-major] Brain Neoplasms / pathology. Frontal Lobe. Oligodendroglioma / secondary
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Time Factors

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  • (PMID = 17457022.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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4. Mishra A, El-Naggar AK, DeMonte F, Hanna EY: Endodermal sinus tumor of the paranasal sinuses. Head Neck; 2008 Apr;30(4):539-43
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  • [Title] Endodermal sinus tumor of the paranasal sinuses.
  • BACKGROUND: We report a rare case of endodermal sinus tumor (EST) of the paranasal sinus in a 59-year-old man with a 6-week history of nasal obstruction.
  • METHODS AND RESULTS: High-resolution MRI showed a right nasoethmoid mass with obstructive changes in the sphenoid, frontal, and right maxillary sinuses and orbital and intracranial extension.
  • Immunohistochemical studies showed strong keratin staining in both components and restricted positivity of alpha-fetoprotein in the endodermal sinus-like component.
  • The patient underwent 3 cycles of neoadjuvant chemotherapy consisting of ifosfamide, paclitaxel, and cisplatin, which resulted in significant regression of the tumor, but after the fourth cycle, the mass showed a slight increase in size.
  • The tumor was excised with clear margins through an anterior craniofacial approach to the skull base.
  • Histologic examination of the resected specimen showed extensive fibrosis with residual areas of viable tumor composed mainly of the poorly differentiated component with only residual microscopic foci of EST.
  • Adjuvant postoperative intensity-modulated radiation therapy was administered.
  • At 1-year follow-up, the patient was tumor free, with normal alpha-fetoprotein levels.
  • CONCLUSION: Because of the rarity of this entity, no standardized treatment protocol has been defined.
  • The involvement of the anterior skull base in our case necessitated a radical craniofacial resection, despite a partial response to chemotherapy.
  • [MeSH-major] Carcinoma / pathology. Endodermal Sinus Tumor / pathology. Neoplasms, Multiple Primary / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Humans. Ifosfamide / administration & dosage. Magnetic Resonance Imaging. Male. Middle Aged. Nasal Obstruction / etiology. Neoadjuvant Therapy. Paclitaxel / administration & dosage. Radiotherapy, Adjuvant. Skull Base / pathology

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  • (PMID = 17902152.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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5. Abrahão M, Gonçalves AP, Yamashita R, Dedivitis RA, Santos RO, Nascimento LA, Mudo ML, Ferraz FA, Cervantes O: Frontal sinus adenocarcinoma. Sao Paulo Med J; 2000 Jul 6;118(4):118-20

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  • [Title] Frontal sinus adenocarcinoma.
  • CONTEXT: Paranasal sinus cancer is considered rare, with an incidence of less than 1 per 100,000 per year, with the frontal sinus being the primary site in only 0.3%.
  • We report a case of adenocarcinoma arising in the frontal sinus.
  • CASE REPORT: A 59-year-old woman, secretary, came in February 1998 with a 4-month history of low intensity frontal headache.
  • CT scan showed a soft-tissue mass involving frontal sinus with intracranial invasion through the posterior wall.
  • The anterior ethmoid sinus and the medial aspect of the right orbit were also involved.
  • MRI demonstrated dural thickening in communication with the frontal mass.
  • She underwent an en-bloc tumor resection by craniotomy including orbital clearance.
  • After surgery she had tumor recurrence, and chemotherapy and radiotherapy were started resulting in partial improvement.
  • [MeSH-major] Adenocarcinoma / diagnosis. Frontal Sinus. Paranasal Sinus Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 10887389.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] BRAZIL
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6. Netalkar AS, Sharma RR, Mahapatra AK, Sousa J, Lad SD, Pawar SJ, Mishra GP, Musa MM: An unusual presentation of an intra-parenchymatous frontal yolk sac tumour : case report. Neurol India; 2001 Dec;49(4):395-7
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  • [Title] An unusual presentation of an intra-parenchymatous frontal yolk sac tumour : case report.
  • CT scan showed an intra-parenchymatous right frontal ring enhancing lesion of 2 cms diameter.
  • The patient underwent microsurgical total excision of the tumour, followed by chemotherapy.
  • [MeSH-major] Brain Neoplasms / radiography. Brain Neoplasms / surgery. Endodermal Sinus Tumor / radiography. Endodermal Sinus Tumor / surgery. Frontal Lobe
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Female. Humans. Microsurgery. Tomography, X-Ray Computed. Vinblastine / therapeutic use

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  • (PMID = 11799415.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; PVB protocol
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7. Honda M, Baba H, Yonekura M, Iseki M: Cerebral composite atypical teratoid/rhabdoid tumor and yolk sac tumor in the frontal lobe of an infant. Case report. Neurol Med Chir (Tokyo); 2005 Jun;45(6):318-21
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  • [Title] Cerebral composite atypical teratoid/rhabdoid tumor and yolk sac tumor in the frontal lobe of an infant. Case report.
  • A 1-year-old male infant presented with a rare cerebral composite tumor consisting of atypical teratoid/rhabdoid tumor (AT/RT) with epithelial and mesenchymal components and yolk sac tumor (YST) with Schiller-Duval bodies.
  • Computed tomography and magnetic resonance imaging revealed a large, intra-axial solid tumor with a cyst in the left frontal lobe.
  • Total resection of the tumor was performed.
  • Initial total resection of the tumor was subsequently followed by local recurrence, hydrocephalus, and spinal metastasis.
  • Despite adjuvant chemotherapy, the patient died 9 months after admission.
  • The present case of composite AT/RT and YST in the frontal lobe indicates the poor prognosis of such tumors.
  • [MeSH-major] Brain Neoplasms / pathology. Endodermal Sinus Tumor / pathology. Frontal Lobe / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology

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  • (PMID = 15973067.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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8. Bambakidis NC, Cohen AR: Intracranial complications of frontal sinusitis in children: Pott's puffy tumor revisited. Pediatr Neurosurg; 2001 Aug;35(2):82-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial complications of frontal sinusitis in children: Pott's puffy tumor revisited.
  • The objective of the present study is to describe the diagnosis and treatment of intracranial complications of frontal sinusitis (Pott's puffy tumor) in a series of pediatric patients at our institution.
  • A rare entity, Pott's puffy tumor has been reported in only 21 pediatric cases in the literature of the antibiotic era.
  • The hospital records and radiographic files at Rainbow Babies and Childrens Hospital, Cleveland, Ohio, USA, over the previous 16 years were retrospectively reviewed in a search for patients with the diagnosis of Pott's puffy tumor, defined as scalp swelling and associated intracranial infection.
  • All patients presented with frontal scalp swelling, and other common symptoms included headache, fever, nasal drainage and frontal sinus tenderness.
  • [MeSH-major] Brain Abscess / etiology. Frontal Sinusitis / complications
  • [MeSH-minor] Adolescent. Adult. Anti-Bacterial Agents / therapeutic use. Bacterial Infections / drug therapy. Child. Female. Frontal Lobe / diagnostic imaging. Frontal Lobe / pathology. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2001 S. Karger AG, Basel
  • (PMID = 11549918.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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9. Hatta C, Ogasawara H, Okita J, Kubota A, Ishida M, Sakagami M: Non-Hodgkin's malignant lymphoma of the sinonasal tract--treatment outcome for 53 patients according to REAL classification. Auris Nasus Larynx; 2001 Jan;28(1):55-60
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  • [Title] Non-Hodgkin's malignant lymphoma of the sinonasal tract--treatment outcome for 53 patients according to REAL classification.
  • The primary sites were the nasal cavity (67.8%), maxillary sinus (20.8%), ethmoidal sinus (9.4%), and frontal sinus (1.9%).
  • Based on the origin of the tumor cells, the authors classified NHL of the sinonasal tract into five groups with the REAL classification of Japan: diffuse large B-cell lymphoma (22.6%), peripheral T-cell lymphomas (15.1%), angiocentric lymphoma (35.9%), other lymphomas and unclassified types.
  • Of 53 patients, 39 (73.6%) received chemotherapy and radiotherapy, eight patients received chemotherapy alone, and four patients received radiotherapy alone.
  • The cumulative 5-year survival rates were 28.5% for all of the types, 55.0% for diffuse large B-cell lymphoma, 33.3% for peripheral T-cell lymphoma, and 19.7% for angiocentric lymphoma.
  • Results suggest that conventional combined treatment (CHOP chemotherapy+radiotherapy) is ineffective for NHL of the sinonasal tract, and especially so for NHL in the nasal cavity, NHL with tumor cells with positive T-cell markers, NHL further than Stage IIE and NHL with B symptoms.
  • CONCLUSION:. (1) In light of this ineffectiveness, new therapies must be developed to improve patient outcome instead of the conventional combined treatment;.
  • [MeSH-major] Lymphoma, Non-Hodgkin / therapy. Paranasal Sinus Neoplasms / drug therapy. Paranasal Sinus Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging / classification. Survival Rate. Treatment Outcome

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  • (PMID = 11137364.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
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10. Kajikawa H, Chatani M, Matsushiro N, Kamakura T, Kitamura T, Okumura S: [A case of advanced adenocarcinoma of the ethmoid sinus treated by chemoradiation with S-1]. Gan To Kagaku Ryoho; 2009 May;36(5):871-3
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  • [Title] [A case of advanced adenocarcinoma of the ethmoid sinus treated by chemoradiation with S-1].
  • We report a case of advanced adenocarcinoma in the left ethmoid sinus invading the frontal sinus, the frontal skull base and the orbits(T4bN0M0 and Stage IVB).
  • With the goal of functional preservation, we carried out radiation therapy with total 60 Gy irradiation and chemotherapy with S-1 80 mg/body/day before a radical operation.
  • The tumor clinically disappeared without surgical treatment, and there was no sign of recurrence for 2.5 years.
  • When we decide the treatment policy for advanced adenocarcinoma of the ethmoid sinus, chemoradiotherapy wit S-1 might be one of the effective treatments before radical operation to control the disease with preservation of functions.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ethmoid Sinus. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy. Oxonic Acid / therapeutic use. Tegafur / therapeutic use
  • [MeSH-minor] Combined Modality Therapy. Drug Combinations. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Remission Induction. Tomography, X-Ray Computed

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  • (PMID = 19461198.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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11. Kumar A, Bentley T: Sinonasal poorly differentiated carcinoma presenting clinically as esthesioneuroblastoma. J Clin Oncol; 2004 Jul 15;22(14_suppl):5605

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  • METHOD: A 54 year old white male presented with progressive double vision, left nasal congestion, proptosis of left eye and intermittent pain in left eye and frontal sinus region of 7-8 months duration.
  • Examination revealed a large deforming mass involving the left proximal nasal cavity extending into the mid forehead protruding through the frontal bone.
  • Intranasal cavity revealed edematous mucosa with soft tissue mass filling mid aspect of nasal cavity on the left.
  • CT scan revealed a large destructive mass involving the left nasal cavity and ethmoid sinus extending into the left orbit with displacement of the globe and destruction of the anterior cranial fossa including the frontal bone.
  • MRI revealed a large sinonasal tumor (5.2x7x7.5cm) extending through the cribriform plate, anteromedial floor of the middle cranial fossa and through the inner and outer table of the frontal bones, more to the left than to the right of midline.
  • He is currently being treated with combined radiation therapy and chemotherapy (carboplatin/paclitaxel).
  • ONB is a rare tumor located in the roof of the nasal cavity and paranasal sinuses.
  • Most patients have locally extensive disease and often, distant metastases at diagnosis.
  • Multimodality approaches (eg, sequential chemotherapy, radiation therapy and craniofacial resection) can cure some patients with localized disease.

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  • (PMID = 28015298.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Neves MC, Lessa MM, Voegels RL, Butugan O: Primary non-Hodgkin's lymphoma of the frontal sinus: case report and review of the literature. Ear Nose Throat J; 2005 Jan;84(1):47-51

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  • [Title] Primary non-Hodgkin's lymphoma of the frontal sinus: case report and review of the literature.
  • Most cases of primary non-Hodgkin's lymphoma of the sinonasal tract occur in the maxillary sinus, ethmoid sinus, and nasal cavity; its occurrence in the frontal sinus is extremely rare.
  • We report a case of primary type B non-Hodgkin's lymphoma of the frontal sinus in a 43-year-old man.
  • The patient complained of frontal headaches that had not improved with analgesic drugs, and he presented with a frontal bulge that involved the left upper eyelid; the bulge had progressively enlarged over a 3-month period A biopsy of the mass identified the type B non-Hodgkin's lymphoma.
  • Immunohistochemical study not only confirmed the histologic type of the tumor, it also provided some important information about the primary tumor site.
  • Advances in immunohistochemistry have shown that type B non-Hodgkin's lymphoma is more common in North American and European patients, whereas subtype T is more common in Asians and in some Latin Americans.
  • The treatment of this condition is still controversial, but the combination of radiotherapy and chemotherapy has yielded the best results in all stages of the disease.
  • [MeSH-major] Frontal Sinus. Lymphoma, B-Cell / diagnosis. Lymphoma, B-Cell / therapy. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / therapy

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  • (PMID = 15742775.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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13. Demirci H, Marentette LJ, Nelson CC: The transglabellar/subcranial approach for surgical excision of periocular second tumors in retinoblastoma. Orbit; 2008;27(4):285-91
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  • METHODS: Seven retinoblastoma patients with periocular second tumor involving anterior skull base underwent surgical resection by transglabellar/subcranial approach in a single center.
  • RESULTS: The most common presenting symptom in retinoblastoma patients with periocular second tumor was difficulty in maintaining the prosthesis in three patients (43%), followed by epistaxis in one (14%), palpable orbital mass in one (14%), persistent periocular swelling in one (14%), and visual loss in one (14%) patient.
  • Surgical resection by the transglabellar/subcranial approach was the only treatment in one (14%) patient with sphenoid wing meningioma and was combined with chemotherapy in three (43%) patients, and with both external beam radiotherapy and chemotherapy in three (43%) patients.
  • The transglabellar/subcranial approach can be used for surgical resection of periocular second tumor involving skull base with low morbidity.
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Eye Enucleation. Eyebrows. Female. Frontal Bone. Humans. Leiomyosarcoma / surgery. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Orbital Neoplasms / surgery. Osteosarcoma / surgery. Paranasal Sinus Neoplasms / surgery. Radiotherapy. Retrospective Studies. Survival Rate. Tomography, X-Ray Computed

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  • (PMID = 18716966.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Nguyen MM, Corr AS, Evans CP: Testicular cancer metastatic exclusively to the brain and spleen. Urology; 2004 Jan;63(1):176-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient initially presented with seizures and underwent craniotomy for presumed primary brain tumor, with a delayed diagnosis of testicular cancer as the true primary.
  • [MeSH-major] Frontal Lobe / pathology. Splenic Neoplasms / secondary. Supratentorial Neoplasms / secondary. Teratoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Craniotomy. Diagnosis, Differential. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / secondary. Endodermal Sinus Tumor / surgery. Etoposide / administration & dosage. Humans. Male. Middle Aged. Neoadjuvant Therapy. Orchiectomy. Remission Induction. Seizures / etiology. Seminoma / diagnosis. Seminoma / drug therapy. Seminoma / secondary. Seminoma / surgery. Splenectomy


15. Durko M, Murlewska A, Gryczyński M, Ratyńska M, Pietruszewska W: [Angiofibroma of the nasal cavity and anterior ethmoid cells--problems in differential diagnosis]. Otolaryngol Pol; 2007;61(5):736-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Angiofibroma of the nasal cavity and anterior ethmoid cells--problems in differential diagnosis].
  • It is a relatively rare benign fibrovascular tumor originating in the posterior lateral wall of the nasopharynx with only a very few cases diagnosed in females.
  • Patient presented in past medical history: lymphoma malignum--abdominal location--surgical treatment and chemotherapy (1986) with no clinical signs of recurrence.
  • Diagnosis based on histopathologic examination with immunochemical staining (vimentin, actin, desmin, S-100 protein).
  • CT of paranasal sinuses in frontal and axial plains--left nasal cavity filled with a solid pathologic tissue.
  • In the left anterior ethmoid cells extension of the tumor could be seen.
  • Surgical treatment--tumor has been surgically resected with no complications.
  • CONCLUSION: Although angiofibroma in females is an extremely rare tumor of a sinonasal tract it should be taken into consideration in the differential diagnosis of all nasal cavity tumors (especially solitary fibrous tumor).
  • It is not possible to make differential diagnosis on physical examination.
  • The only way to confirm the diagnosis is histopathologic examination with immunochemical staining.
  • [MeSH-major] Angiofibroma / pathology. Ethmoid Sinus / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Nasal Cavity / surgery. Tomography, X-Ray Computed

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  • (PMID = 18552009.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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16. Greci V, Stefanello D, Di Giancamillo M, Mortellaro CM: Sinonasal tumor in 3 dogs after successful topical treatment for frontal sinus aspergillosis. Can Vet J; 2009 Nov;50(11):1191-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sinonasal tumor in 3 dogs after successful topical treatment for frontal sinus aspergillosis.
  • Three dogs diagnosed with aspergillosis developed sinonasal tumors several months after successful treatment with topical clotrimazole solution.
  • Chronic rhinosinusitis was also detected in all cases prior to diagnosis of sinonasal tumors.
  • The inflammatory response to Aspergillus, clotrimazole treatment, and chronic inflammation after treatment are discussed as possible neoplastic promoting factors.
  • [MeSH-major] Antifungal Agents / adverse effects. Clotrimazole / adverse effects. Dog Diseases / chemically induced. Paranasal Sinus Neoplasms / veterinary
  • [MeSH-minor] Administration, Intranasal. Administration, Topical. Animals. Aspergillosis / drug therapy. Dogs. Fatal Outcome. Female. Frontal Sinus / microbiology. Frontal Sinus / pathology. Male

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  • (PMID = 20119545.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal = La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antifungal Agents; G07GZ97H65 / Clotrimazole
  • [Other-IDs] NLM/ PMC2764461
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17. Narasimhan K, Kucuk O, Lin HS, Heilbrun LK, Carron M, Venkatramanamoorthy R, Mathog R: Sinonasal mucosal melanoma: a 13-year experience at a single institution. Skull Base; 2009 Jul;19(4):255-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most common anatomic locations were the maxillary sinus and nasal cavity.
  • Seventy-two percent presented with tumors extending to the skull base, frontal sinus, orbit, or cranium.
  • Tumor size ranged from 0.3 cm to 5.3 cm.
  • Most common surgical procedure was medial maxillectomy (12 patients).
  • Eight patients received chemotherapy, ten received radiotherapy and six received both.
  • CONCLUSION: SNMM remains a disease that has eluded breakthroughs in treatment.
  • Further research in adjuvant therapies will be necessary to improve outcomes.

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  • (PMID = 20046593.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA022453
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2731469
  • [Keywords] NOTNLM ; Melanoma / nasal cavity / sinonasal mucosal melanoma / sinus
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18. Hanna E, DeMonte F, Ibrahim S, Roberts D, Levine N, Kupferman M: Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results. Arch Otolaryngol Head Neck Surg; 2009 Dec;135(12):1219-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS: All patients with biopsy-proved malignant neoplasm of the sinonasal region who were treated with endoscopic resection between 1992 and 2007 were included in the study, and their charts were reviewed for demographics, histopathologic findings, treatment details, and outcome.
  • RESULTS: Of a total of 120 patients, 93 (77.5%) underwent an exclusively endoscopic approach (EEA) and 27 (22.5%) underwent a cranioendoscopic approach (CEA) in which the surgical resection involved the addition of a frontal or subfrontal craniotomy to the transnasal endoscopic approach.
  • Of the 120 patients, 41% presented with previously untreated disease, 46% presented with persistent disease that had been partially resected, and 13% presented with recurrent disease after prior treatment.
  • The most common site of tumor origin was the nasal cavity (52%), followed by the ethmoid sinuses (28%).
  • The most common tumor types were esthesioneuroblastoma (17%), sarcoma (15%), adenocarcinoma (14%), melanoma (14%), and squamous cell carcinoma (13%).
  • Of the 120 patients, 50% were treated with surgery alone, 37% received postoperative radiation therapy, and 13% were treated with surgery, radiation therapy, and chemotherapy.
  • Our results suggest that, in well-selected patients and with appropriate use of adjuvant therapy, endoscopic resection of sinonasal cancer results in acceptable oncologic outcomes.
  • [MeSH-major] Endoscopy. Paranasal Sinus Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / surgery. Chemotherapy, Adjuvant. Child. Craniotomy. Disease-Free Survival. Esthesioneuroblastoma, Olfactory / surgery. Ethmoid Sinus. Female. Humans. Male. Melanoma / surgery. Middle Aged. Neoplasm Recurrence, Local. Nose Neoplasms / mortality. Nose Neoplasms / surgery. Radiotherapy, Adjuvant. Retrospective Studies. Sarcoma / surgery

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  • (PMID = 20026819.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Ortega JM, Gómez-Angulo JC, Aragonés P, Jerez P, Alcázar L, Rodríguez-Barbero JM, Salazar F, del Pozo JM: [Leiomyosarcoma of the paranasal sinuses with intracranial involvement: report of a clinical case and review of the literature]. Neurocirugia (Astur); 2001 Aug;12(4):331-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Leiomiosarcoma de senos paranasales con extensión intracraneal: presentación de un caso clínico y revisión de la literatura.
  • We describe a 53 year old man with a two months history of frontal headache and right visual loss, with complete right blindness at the moment of diagnosis.
  • Computerized Tomography showed a neoplasm involving both paranasal sinuses and sellar region, with bilateral orbital extension.
  • The patient died of cerebellar metastasis 4 months after the initial diagnosis and treatment.
  • Leiomyosarcoma of the sinonasal tract is an unusual tumor, and we have found only 63 cases previously reported.
  • Surgery is the treatment of choice, as far as radiotherapy or chemotherapy do not appear to slow disease progression.
  • Leiomyosarcoma of the sinonasal tract may be regarded as a locally aggressive neoplasm with only limited metastatic potential.
  • [MeSH-major] Brain Neoplasms / diagnosis. Leiomyosarcoma / diagnosis. Paranasal Sinus Neoplasms / diagnosis
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 11706678.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 28
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20. Danesi G, Panizza B, Mazzoni A, Calabrese V: Anterior approaches in juvenile nasopharyngeal angiofibromas with intracranial extension. Otolaryngol Head Neck Surg; 2000 Feb;122(2):277-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although surgery is regarded as the mainstay of treatment for juvenile nasopharyngeal angiofibromas (JNAs), ancillary treatment modalities such as radiotherapy and on rare occasions chemotherapy are still recommended by many for intracranial extension with apparent radiologic involvement of the cavernous sinus and internal carotid artery.
  • Further, most authors undertaking surgical excision of this subgroup of patients would recommend a lateral or combined frontal and lateral approach for its removal.
  • Although in these cases, on radiography the cavernous sinus often looked to be invaded and the internal carotid artery was displaced superolaterally, there was no difficulty in establishing a plane of dissection.
  • Total removal was achieved in 11 of the 14 cases with a single-stage procedure.
  • Of the 3 cases with residual tumor, only 1 occurred intracranially.
  • For the extracranial residual tumors 1 required a midface degloving and the other, with a 1-cm residual tumor in the nasopharynx, has been treated conservatively for 6 years with no evidence of growth.
  • On the rare occasion that a lateral approach, with its attendant permanent conductive hearing loss, is found to be necessary for total tumor removal, this can be done as a staged procedure.
  • This may be necessary when the tumor has spread lateral to the horizontal internal carotid artery.
  • [MeSH-minor] Adolescent. Adult. Carotid Artery, Internal / pathology. Cavernous Sinus / pathology. Child. Humans. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 10652407.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Hamilton JF, Bartkowski HB, Rock JP: Management of CNS mucormycosis in the pediatric patient. Pediatr Neurosurg; 2003 Apr;38(4):212-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rhinocerebral mucormycosis (RM) is a rare, rapidly progressive disorder caused by fungi from the Mucoraceae family.
  • Mucormycosis normally presents in poorly controlled diabetics, intravenous drug abusers and immunocompromised patients.
  • Many have advocated radical surgical resection (i.e. exenteration of the cavernous sinus with carotid sacrifice and en bloc resection) with administration of amphotericin B.
  • A 14-year-old diabetic male presented with RM with involvement of the bilateral frontal lobes, right basal ganglia and temporal lobe.
  • Additionally, there was involvement of the sphenoid sinus and right cavernous sinus with extension into the posterior fossa along the course of the trigeminal nerve and encasement with narrowing of the right carotid artery.
  • The patient underwent sinus endoscopy with debridement of necrotic fungal tissue and bone.
  • The patient continued to receive intrathecal and intravenous antibiotics as well as hyperbaric oxygen therapy.
  • The patient was clinically and radiographically free of disease 1 year after diagnosis.
  • While invasive RM is generally a fatal disease, this rare disorder can be treated successfully without radical resection, particularly if multimodality treatment options are implemented.

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  • [Copyright] Copyright 2003 S. Karger AG, Basel
  • (PMID = 12646741.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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