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Items 1 to 26 of about 26
1. Dartnell J, Pilling J, Ferner R, Cane P, Lang-Lazdunski L: Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor. J Thorac Oncol; 2009 Jan;4(1):135-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant triton tumor of the brachial plexus invading the left thoracic inlet: a rare differential diagnosis of pancoast tumor.
  • Malignant triton tumor is a divergent malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation.
  • We report a case of malignant triton tumor arising in the brachial plexus of a 28-year-old women with neurofibromatosis type 1.
  • Fluorodeoxyglucose-positron emission tomography-computed tomography before excision demonstrated a tumor with a maximum standard uptake value of 21 at 4 hours postinjection.
  • The patient underwent complete excision of the tumor through median sternotomy and left supraclavicular approach.
  • Adjuvant radiotherapy and chemotherapy were planned but the patient died of metastatic disease within 3 months of surgical resection.
  • [MeSH-major] Brachial Plexus / pathology. Neurilemmoma / diagnosis. Pancoast Syndrome / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Thoracic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Female. Fluorodeoxyglucose F18. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neurofibromatosis 1 / complications. Positron-Emission Tomography. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • (PMID = 19096322.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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2. Chen YM, Hu GC, Cheng SJ: Bilateral neuralgic amyotrophy presenting with left vocal cord and phrenic nerve paralysis. J Formos Med Assoc; 2007 Aug;106(8):680-4
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  • This article reports the difference between neuralgic amyotrophy and neuropathy caused by chemotherapy and radiation treatment which manifested with severe shoulder pain followed by marked weakness of bilateral upper arms and involvement of cranial nerves.
  • The diagnosis of neuralgic amyotrophy was supported and differentiated from tumor-induced and radiation-induced neuropathy by clinical presentation, electrophysiologic and imaging studies.
  • Unlike previous reports of the onset of neuralgic amyotrophy being associated with initiation of radiation treatment in cancer patients, this report demonstrates that neuralgic amyotrophy can occur at any point of the malignant disease process after radiation and chemotherapy.

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  • (PMID = 17711804.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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3. Davis GA, Knight S: Pancoast tumor resection with preservation of brachial plexus and hand function. Neurosurg Focus; 2007;22(6):E15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancoast tumor resection with preservation of brachial plexus and hand function.
  • Modern treatment includes induction chemotherapy and radiotherapy prior to resection, but many authors also resect the T-1 nerve root (with or without the C-8 nerve root and the lower trunk of the brachial plexus) as part of the therapy, causing significant loss of hand function in many patients.
  • The current authors determined whether a different approach allowing preservation of the brachial plexus and hand function could be adopted without compromising patient survival.
  • METHODS: Five patients harboring Pancoast tumors with brachial plexus involvement underwent surgery performed by both a neurosurgeon and thoracic surgeon.
  • In all cases the tumor was resected from the brachial plexus using neurolysis while preserving the C-8 and T-1 nerve roots and lower trunk of the brachial plexus.
  • CONCLUSIONS: Although this patient series is small, the findings are extremely encouraging and suggest that the described treatment paradigm preserves survival as well as hand function in patients with Pancoast tumors.
  • [MeSH-major] Brachial Plexus / physiology. Brachial Plexus / surgery. Hand / physiology. Pancoast Syndrome / surgery. Peripheral Nervous System Neoplasms / surgery. Recovery of Function / physiology

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  • (PMID = 17613206.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Smith ER, Ott M, Wain J, Louis DN, Chiocca EA: Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature. J Neurosurg; 2002 Jan;96(1 Suppl):107-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature.
  • Involvement of peripheral nerves by meningioma, either by a primary tumor or through secondary extension of an intraaxial lesion, is a much rarer entity; there have been only two reported primary brachial plexus meningiomas and one description of secondary involvement of the brachial plexus by extension of an intraaxial lesion.
  • The authors present the case report of a 36-year-old man who was initially treated for a thoracic spinal meningioma that infiltrated the brachial plexus.
  • After resection, progressive and massive growth with infiltration of the brachial plexus and pleural cavity occurred over a 5-year period despite radio- and chemotherapy.
  • [MeSH-major] Brachial Plexus Neuropathies / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neoplasm Recurrence, Local / surgery. Peripheral Nervous System Neoplasms / surgery. Thoracic Neoplasms / surgery
  • [MeSH-minor] Adult. Decompression, Surgical. Fatal Outcome. Follow-Up Studies. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Neoplasm Invasiveness. Reoperation. Thoracic Vertebrae / pathology. Thoracic Vertebrae / surgery. Tomography, X-Ray Computed

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  • (PMID = 11795697.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Rawal A, Yin Q, Roebuck M, Sinopidis C, Kalogrianitis S, Helliwell TR, Frostick S: Atypical and malignant peripheral nerve-sheath tumors of the brachial plexus: report of three cases and review of the literature. Microsurgery; 2006;26(2):80-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical and malignant peripheral nerve-sheath tumors of the brachial plexus: report of three cases and review of the literature.
  • Tumor involvement of the brachial plexus is uncommon.
  • The most common intrinsic neoplasms involving the brachial plexus are benign neurilemmomas and neurofibromas that are usually associated with neurofibromatosis-1 (NF-1).
  • MPNST of the brachial plexus should be treated with an adequate wide local excision, with adjuvant high-dose radiotherapy pre- or postoperatively.
  • The role of chemotherapy in the treatment of MPNST is not clearly defined, but it may have some benefit in salvaging treatment failures.
  • [MeSH-major] Brachial Plexus. Nerve Sheath Neoplasms / pathology. Nerve Sheath Neoplasms / surgery

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  • (PMID = 16538633.001).
  • [ISSN] 0738-1085
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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6. Vranken JH, Zuurmond WW, de Lange JJ: Continuous brachial plexus block as treatment for the Pancoast syndrome. Clin J Pain; 2000 Dec;16(4):327-33

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  • [Title] Continuous brachial plexus block as treatment for the Pancoast syndrome.
  • BACKGROUND: Six patients with severe neuropathic pain caused by a Pancoast tumor were treated with the continuous administration of local anesthetics.
  • These patients had not responded to any other treatment, including nonsteroidal anti-inflammatory drugs, opioids, dexamethasone, tricyclic antidepressants, anticonvulsants, ketamine, and transcutaneous electric nerve stimulation.
  • INTERVENTIONS: An axillary catheter was placed in the brachial plexus using a posterior approach that has not been described previously.
  • CONCLUSIONS: We conclude that neuropathic pain may be treated by local anesthetics administered through an axillary catheter placed in the brachial plexus.
  • [MeSH-major] Brachial Plexus. Nerve Block / methods. Neuralgia / drug therapy. Neuralgia / etiology. Pancoast Syndrome / complications
  • [MeSH-minor] Aged. Aged, 80 and over. Anesthetics, Local / administration & dosage. Axilla. Brachial Plexus Neuropathies / etiology. Brachial Plexus Neuropathies / therapy. Catheterization / methods. Female. Humans. Male. Middle Aged. Pain Measurement. Patient Satisfaction

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  • (PMID = 11153789.001).
  • [ISSN] 0749-8047
  • [Journal-full-title] The Clinical journal of pain
  • [ISO-abbreviation] Clin J Pain
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Local
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7. Hébert-Blouin MN, Bishop AT, Shin AY, Wetmore C, Spinner RJ: Tardy spinal cord tumor following avulsive brachial plexus injury: coincidental or causal? World Neurosurg; 2010 Aug-Sep;74(2-3):368-73
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  • [Title] Tardy spinal cord tumor following avulsive brachial plexus injury: coincidental or causal?
  • OBJECTIVE: Late neurologic deterioration after brachial plexus injury (BPI) is uncommon and may be caused by multiple etiologies.
  • RESULTS: Magnetic resonance imaging and computed tomography myelogram revealed spinal cord herniation at the same level of the previous nerve root avulsions.
  • Despite craniospinal radiotherapy and different regimens of chemotherapy, he died 4 years later from leptomeningeal spread.
  • The probable coincidental versus possible causal interrelationship of these two processes (BPI and spinal cord tumor) is discussed, but no conclusions can be reached.
  • [MeSH-major] Astrocytoma / etiology. Brachial Plexus / injuries. Spinal Cord Neoplasms / etiology
  • [MeSH-minor] Antineoplastic Agents, Alkylating / therapeutic use. Child. Combined Modality Therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Fatal Outcome. Horner Syndrome / complications. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Meningocele / pathology. Muscle Weakness / etiology. Neurosurgical Procedures. Off-Road Motor Vehicles. Reconstructive Surgical Procedures. Spine / pathology

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] World Neurosurg. 2010 Aug-Sep;74(2-3):275-6 [21492559.001]
  • (PMID = 21492572.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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8. Vranken JH, van der Vegt MH, Zuurmond WW, Pijl AJ, Dzoljic M: Continuous brachial plexus block at the cervical level using a posterior approach in the management of neuropathic cancer pain. Reg Anesth Pain Med; 2001 Nov-Dec;26(6):572-5
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  • [Title] Continuous brachial plexus block at the cervical level using a posterior approach in the management of neuropathic cancer pain.
  • BACKGROUND AND OBJECTIVES: Neuropathic cancer pain due to tumor growth near the brachial plexus is often treated with a combination of nonsteroidal anti-inflammatory drugs, tricyclic antidepressants, anticonvulsants, and oral or transdermal opioids.
  • We propose placement of a catheter along the brachial plexus using a posterior approach for patients not responding to the above-mentioned treatment.
  • CASE REPORT: We describe 2 patients with neuropathic cancer pain in the arm and shoulder despite treatment with dexamethasone, amitriptyline, gabapentin, opioids, and, in 1 patient, oral ketamine.
  • Continuous administration of local anesthetics via a brachial plexus catheter inserted at the cervical level using a posterior approach resulted in a markedly improved analgesia and decreased opioid requirement.
  • CONCLUSION: Continuous brachial plexus block should be considered in patients with severe neuropathic cancer pain in the arm and shoulder.
  • To achieve sufficient pain relief for prolonged periods of time, a catheter was inserted to block the brachial plexus using a posterior approach.
  • [MeSH-major] Brachial Plexus. Neoplasms / complications. Nerve Block. Pain / drug therapy. Pain / etiology

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  • (PMID = 11707798.001).
  • [ISSN] 1098-7339
  • [Journal-full-title] Regional anesthesia and pain medicine
  • [ISO-abbreviation] Reg Anesth Pain Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Local; Y8335394RO / Bupivacaine
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9. Qayyum A, MacVicar AD, Padhani AR, Revell P, Husband JE: Symptomatic brachial plexopathy following treatment for breast cancer: utility of MR imaging with surface-coil techniques. Radiology; 2000 Mar;214(3):837-42
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  • [Title] Symptomatic brachial plexopathy following treatment for breast cancer: utility of MR imaging with surface-coil techniques.
  • PURPOSE: To investigate the clinical utility and diagnostic accuracy of magnetic resonance (MR) imaging in patients with symptomatic brachial plexopathy following treatment for breast cancer.
  • MATERIALS AND METHODS: Fifty patients with symptoms of brachial plexopathy (principally pain, weakness, and paresthesia) who had received treatment for breast cancer, which included surgery, radiation therapy, and cytotoxic chemotherapy, underwent MR imaging at 1.5 T.
  • MR imaging was performed by using a body coil, which was supplemented with surface-coil imaging of the cervical spine and shoulder-coil imaging of the brachial plexus.
  • At review, two observers attempted to discriminate between tumor recurrence and nonmalignant causes of symptoms.
  • RESULTS: Of 27 patients demonstrated to have tumor recurrence, 26 were correctly identified by using MR imaging; the recurrence was directly related to the brachial plexus in 17.
  • The MR criteria used for detection of tumor yielded a sensitivity of 96%, specificity of 95%, positive predictive value of 96%, and negative predictive value of 95%.
  • CONCLUSION: MR imaging is reliable and accurate in the diagnosis of symptomatic brachial plexopathy following breast cancer therapy.
  • [MeSH-major] Brachial Plexus Neuropathies / diagnosis. Breast Neoplasms / therapy. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Brachial Plexus / pathology. Combined Modality Therapy. Female. Humans. Image Enhancement. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Sensitivity and Specificity


10. Rao RD, Robins HI: Non-Hodgkin's tumor and Pancoast's syndrome. Oncol Rep; 2001 Jan-Feb;8(1):165-6
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  • [Title] Non-Hodgkin's tumor and Pancoast's syndrome.
  • Chest X-ray and MRI revealed a right apical lung tumor (presumed to be a primary lung cancer), with brachial plexus infiltration and spinal cord compression.
  • The patient subsequently received chemotherapy, and is now in remission.
  • This case illustrates the importance of a tissue diagnosis before initiating therapy for a Pancoast's tumor.
  • [MeSH-major] Carcinoma / diagnosis. Lung Neoplasms / diagnosis. Lymphoma, Non-Hodgkin / diagnosis. Pancoast Syndrome / etiology

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  • (PMID = 11115591.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] GREECE
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11. Peláez R, Pascual G, Aguilar JL, Atanassoff PG: Paravertebral cervical nerve block in a patient suffering from a Pancoast tumor. Pain Med; 2010 Dec;11(12):1799-802
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  • [Title] Paravertebral cervical nerve block in a patient suffering from a Pancoast tumor.
  • In patients with aggressive tumors resistant to conventional pain treatment, regional anaesthesia frequently becomes an alternative therapy.
  • Cervical paravertebral nerve block among several access options to the brachial plexus is barely ever used.
  • We present a case with severe shoulder and upper extremity pain owing to an expanding Pancoast tumor exhibiting compression upon the brachial plexus.
  • Continuous intrathecal morphine infusion and adjuvant treatment was not sufficient to render the patient pain-free.
  • [MeSH-major] Morphine / therapeutic use. Nerve Block / methods. Nerve Compression Syndromes. Pain / drug therapy. Pancoast Syndrome / complications
  • [MeSH-minor] Adult. Analgesics, Opioid / therapeutic use. Brachial Plexus / pathology. Catheters, Indwelling. Cervical Vertebrae. Humans. Male

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  • [Copyright] Wiley Periodicals, Inc.
  • (PMID = 21134120.001).
  • [ISSN] 1526-4637
  • [Journal-full-title] Pain medicine (Malden, Mass.)
  • [ISO-abbreviation] Pain Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 76I7G6D29C / Morphine
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12. Goubier JN, Teboul F, Oberlin C: [Desmoid tumors and brachial plexus]. Chir Main; 2003 Aug;22(4):203-6

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  • [Title] [Desmoid tumors and brachial plexus].
  • [Transliterated title] Tumeurs desmoïdes et plexus brachial.
  • The aim of our paper is to assess the functional results and specific difficulties encountered in the treatment of desmoid tumors located near the brachial plexus.
  • Seven patients with a desmoid tumor in this region were followed for at least 2 years (average 59 months).
  • Three patient had postoperatively chemotherapy and 1 patient had radiation therapy.
  • The margins of desmoid tumor resection have to be wide to avoid local recurrence.
  • However, nerves and blood vessels have to be preserved in order to maintain upper limb function and there may well be a need for adjuvant therapy.
  • [MeSH-major] Brachial Plexus. Fibromatosis, Aggressive / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology

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  • (PMID = 14611074.001).
  • [ISSN] 1297-3203
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 10
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13. Jarmundowicz W, Jabłoński P, Załuski R: [Brachial plexus tumors--neurosurgical treatment]. Neurol Neurochir Pol; 2002 Sep-Oct;36(5):925-35

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  • [Title] [Brachial plexus tumors--neurosurgical treatment].
  • Tumours of the brachial plexus according to present classification are included to soft tissue tumours.
  • There is also a few number of publications regarding tumours of the brachial plexus.
  • Therefore the aim of the study was to present our experience in the surgical treatment of tumours of the brachial plexus basing on the material of 5 cases treated in the years 1997-2001.
  • In 3 cases tumours of the brachial plexus invaded the spinal canal through the intervertebral foramen and caused spinal cord compression (type A).
  • In 2 cases tumours involved only plexus elements (type B).
  • In 2 cases tumours were associated with neurofibromatosis type II.
  • In case of schwannomas and neurofibromas the surgical removal was radical without impairment of brachial plexus function.
  • In case of a giant schwannoma malignum tumor, which caused flaccid paresis and symptoms of insufficient blood, supply with severe pain in the upper limb radical extirpation was also possible.
  • In type A tumours in the first stage intraspinal part of the tumor was removed.
  • The result of treatment of benign tumours was very good with complete function recovery of the upper limb, pain disappearance and no symptoms of recurrence in the long postoperative period.
  • The patient died 12 months after the operation because of tumor dissemination.
  • Benign tumours of the brachial plexus can be effectively surgically treated using microsurgical techniques and, if necessary, nerve grafting.
  • In case of malignant tumours many authors also recommend surgery with optimal sparing of the brachial plexus function and subsequent radio and chemotherapy.
  • [MeSH-major] Brachial Plexus / surgery. Neurilemmoma / surgery. Neurofibroma / surgery. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 12523117.001).
  • [ISSN] 0028-3843
  • [Journal-full-title] Neurologia i neurochirurgia polska
  • [ISO-abbreviation] Neurol. Neurochir. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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14. Jaeckle KA: Neurological manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol; 2004 Dec;24(4):385-93
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  • Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas.
  • Later, weakness and focal sensory disturbances occur in the distribution of plexus involvement.
  • Treatment of metastatic plexopathy is palliative and includes radiotherapy to the tumor mass, chemotherapy, and symptomatic treatment.
  • In selected cases, subtotal surgical resection of the tumor may be warranted.
  • The response to therapy is modest and generally short-lived.
  • [MeSH-major] Brachial Plexus Neuropathies / etiology. Peripheral Nervous System Neoplasms / secondary. Radiotherapy / adverse effects
  • [MeSH-minor] Diagnostic Imaging / methods. Humans. Lung Neoplasms / pathology. Lung Neoplasms / physiopathology. Lung Neoplasms / therapy

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  • (PMID = 15637650.001).
  • [ISSN] 0271-8235
  • [Journal-full-title] Seminars in neurology
  • [ISO-abbreviation] Semin Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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15. Wasner G, Hilpert F, Schattschneider J, Binder A, Pfisterer J, Baron R: Docetaxel-induced nail changes--a neurogenic mechanism: a case report. J Neurooncol; 2002 Jun;58(2):167-74
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  • Docetaxel is a new taxoid widely used in chemotherapy for advanced breast cancer and other solid malignancies.
  • We report a patient with a complete peripheral palsy of the right arm due to advanced breast cancer with diffuse tumor infiltration of the brachial plexus.
  • Treatment with docetaxel led to onycholysis at all extremities except the paretic hand.
  • [MeSH-major] Arm. Breast Neoplasms / complications. Breast Neoplasms / drug therapy. Nail Diseases / chemically induced. Paclitaxel / adverse effects. Paclitaxel / analogs & derivatives. Paralysis / etiology. Taxoids
  • [MeSH-minor] Afferent Pathways / physiopathology. Brachial Plexus / pathology. Efferent Pathways / physiopathology. Female. Humans. Middle Aged. Motor Neurons / physiology. Neoplasm Invasiveness. Neural Conduction. Neurologic Examination. Neurons, Afferent / physiology. Parasympathetic Nervous System / physiopathology. Sensory Thresholds. Skin / innervation. Sympathetic Nervous System / physiopathology. Vibration

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  • (PMID = 12164689.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; P88XT4IS4D / Paclitaxel
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16. Johansson S, Svensson H, Denekamp J: Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients. Int J Radiat Oncol Biol Phys; 2000 Oct 1;48(3):745-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To evaluate the incidence and prevalence of various signs of late morbidity, their time of appearance and pattern of progression during an observation period up to 34 years in breast cancer patients treated with postoperative radiation therapy after radical mastectomy.
  • METHODS AND MATERIALS: A group of 71 breast cancer patients received in 1963-1965 aggressive postoperative telecobalt therapy to the parasternal, axillary, and supraclavicular lymph node regions after total mastectomy and axillary clearance.
  • None of the patients received chemotherapy either prior to, or after the irradiation as part of their primary treatment.
  • The prescribed dose to the three lymph node regions was 44 Gy in 11 fractions.
  • Because of the overlap of the supraclavicular and axillary fields, the dose received by the brachial plexus was not the dose that was prescribed.
  • A retrospective dose calculation showed that the total dose to the brachial plexus was 57 Gy, delivered as a complex combination of 1.8 Gy, 3.4 Gy, and 5.2 Gy fractions.
  • This cohort of patients has now been followed to 34 years and the late side effects of the treatment evaluated and scored.
  • Other neurological findings included unilateral vocal cord paralysis among 5% of the patients, who developed the disease after a median time of 19 years.
  • Local recurrence or the appearance of a new primary tumor infiltrating or causing pressure on the recurrent nerve were vigorously investigated and excluded as possible causes of these symptoms.
  • CONCLUSION: The greatest risk for all cancer patients is the inadequate treatment of their disease, because this is inevitably lethal.
  • The aggressiveness of the therapy and the acceptable risk of complications must therefore be balanced against the risk of recurrence.
  • [MeSH-major] Brachial Plexus / radiation effects. Breast Neoplasms / radiotherapy. Breast Neoplasms / surgery. Peripheral Nervous System Diseases / etiology. Radiation Injuries / complications
  • [MeSH-minor] Adult. Aged. Axilla. Clavicle. Cobalt Radioisotopes / therapeutic use. Combined Modality Therapy. Disease Progression. Female. Fibrosis. Follow-Up Studies. Humans. Lymph Nodes / radiation effects. Mastectomy, Radical. Middle Aged. Postoperative Period. Radiotherapy Dosage. Sternum. Survival Analysis. Time Factors

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  • (PMID = 11020571.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Cobalt Radioisotopes
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17. Davis GA, Knight SR: Pancoast tumors. Neurosurg Clin N Am; 2008 Oct;19(4):545-57, v-vi
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  • Pancoast tumors (superior sulcus tumors or apical lung tumors) typically invade structures at the thoracic outlet, including the inferior elements of the brachial plexus (C8, T1 nerve roots and lower trunk).
  • Historically, these tumors are rapidly fatal, but newer treatment with induction chemotherapy and radiotherapy, followed by surgical resection of the tumor has resulted in improved patient survival.
  • To accomplish oncologic excision, resection of the involved brachial plexus elements is still standard practice in most centers, resulting in loss of hand function and/or development of neuropathic pain.
  • We present a modification of this protocol that incorporates induction chemoradiation, surgical resection of the lung tumor by a thoracic surgeon, and neurolysis and preservation of the brachial plexus by a neurosurgeon.
  • Improved survival outcome, especially in patients demonstrating a pathologic complete response, with preservation of hand function, supports our hypothesis that involved brachial plexus does not need resection in these patients.
  • [MeSH-major] Lung Neoplasms / surgery. Pancoast Syndrome / surgery
  • [MeSH-minor] Aged. Brachial Plexus / physiology. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Movement Disorders / epidemiology. Movement Disorders / etiology. Positron-Emission Tomography. Postoperative Complications / physiopathology. Postoperative Complications / psychology. Recovery of Function. Spinal Nerve Roots / physiology. Survival. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19010280.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Wittig JC, Bickels J, Kollender Y, Kellar-Graney KL, Meller I, Malawer MM: Palliative forequarter amputation for metastatic carcinoma to the shoulder girdle region: indications, preoperative evaluation, surgical technique, and results. J Surg Oncol; 2001 Jun;77(2):105-13; discussion 114
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  • Venography demonstrated obliteration of the axillary vein in each of the patients in whom this procedure was performed.
  • Exploration of the brachial plexus confirmed tumor encasement and unresectability in all patients.
  • CONCLUSIONS: Palliative forequarter amputation is relatively safe and reliable and provides effective pain relief for selected patients with unresectable metastatic carcinoma to the axilla and bony shoulder girdle in whom radiotherapy and/or chemotherapy has not been effective.
  • The triad of pain, motor loss, and an obliterated axillary vein is indicative of brachial plexus infiltration and unresectability.
  • [MeSH-major] Amputation / methods. Brachial Plexus. Pain, Intractable / therapy. Palliative Care. Peripheral Nervous System Neoplasms / secondary. Peripheral Nervous System Neoplasms / surgery. Shoulder / surgery
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged. Outcome Assessment (Health Care). Patient Selection

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  • [Copyright] Copyright 2001 Wiley-Liss, Inc.
  • (PMID = 11398163.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 28
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19. Faisham WI, Zulmi W, Nor Azman MZ, Rhendra Hardy MZ: Forequarter amputation of the upper extremity for musculoskeletal tumors: posterior approach revisited. Med J Malaysia; 2006 Feb;61 Suppl A:57-61
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  • The anterior approach has been the preferred technique of exploration of axillary vessels and brachial plexus.
  • The posterior approach has been condemned to be unreliable and dangerous for most large tumor of the scapula and suprascapular area.
  • We describe a surgical technique using posterior approach of exploration of major vessels for forequarter amputation of upper extremity in eight patients who presented with humeral-scapular tumor.
  • There were six patients with osteosarcoma: three with tumor recurrent and three chemotherapy recalcitrant tumors with vessels involvement.
  • Four patients had fungating ulcer and six patients had multiple pulmonary metastases at the time of surgery.
  • The posterior approach of exploring major vessels for forequarter amputation of upper extremity with musculoskeletal tumor is safe and reliable.
  • [MeSH-major] Amputation / methods. Bone Neoplasms / surgery. Muscle Neoplasms / surgery. Musculoskeletal System / surgery. Upper Extremity / surgery

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  • (PMID = 17042232.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
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20. Papanastassiou I, Ioannou M, Magoulas D, Lalos S, Athanassiou AE, Ziras N, Thanopoulou E, Demertzis N: Chemoembolization facilitates limb salvage surgery in stage III soft tissue sarcoma. J BUON; 2009 Jul-Sep;14(3):507-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemoembolization facilitates limb salvage surgery in stage III soft tissue sarcoma.
  • A 26 year-old male was referred to our unit because of a stage III soft tissue sarcoma in the shoulder girdle-axillary area and reduced forearm-distal arm strength.
  • Imaging studies revealed that the tumor encompassed the axillary artery and brachial plexus.
  • The patient received adjuvant chemotherapy (ifosfamide/mesna, adriamycin, and dacarbazine/MAID) and finally radiation therapy (RT; 6500 cGy total dose).
  • In stage III soft tissue sarcomas, especially in proximity with major nerve/arterial bundles, a multimodality approach is mandatory; chemoembolization is very effective in shrinking the tumor and defining its margins so as to make feasible a LSS.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Embolization, Therapeutic. Limb Salvage. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Agents, Phytogenic / therapeutic use. Chemotherapy, Adjuvant. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Humans. Male. Neoplasm Staging. Radiotherapy, Adjuvant. Vincristine / therapeutic use

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  • (PMID = 19810146.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide
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21. Rivera JA, Christopoulos S, Small D, Trifiro M: Hormonal manipulation of benign metastasizing leiomyomas: report of two cases and review of the literature. J Clin Endocrinol Metab; 2004 Jul;89(7):3183-8
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  • The most commonly affected organs are the lungs, but BMLs have been reported in lymph nodes, deep soft tissues, mesentery, bones, the central nervous system, and the heart.
  • Radical interventions, such as extensive tumor debulking and oophorectomy for hormonal control, although effective in many cases, are not always possible or desirable and carry significant morbidity.
  • Here we present two cases of BMLs to illustrate the role of newer therapeutic agents, the estrogen receptor modulators and the aromatase inhibitors, in the hormonal manipulation of these tumors.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Brachial Plexus Neuropathies / drug therapy. Enzyme Inhibitors / therapeutic use. Leiomyoma / drug therapy. Leiomyoma / pathology. Lung Neoplasms / secondary. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Aromatase Inhibitors. Estrogen Receptor Modulators / therapeutic use. Female. Gonadotropin-Releasing Hormone / agonists. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Neoplasms / diagnosis. Neoplasms / drug therapy. Nitriles / therapeutic use. Radiography, Thoracic. Raloxifene Hydrochloride / therapeutic use. Selective Estrogen Receptor Modulators / therapeutic use. Triazoles / therapeutic use

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  • (PMID = 15240591.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Aromatase Inhibitors; 0 / Enzyme Inhibitors; 0 / Estrogen Receptor Modulators; 0 / Nitriles; 0 / Selective Estrogen Receptor Modulators; 0 / Triazoles; 2Z07MYW1AZ / anastrozole; 33515-09-2 / Gonadotropin-Releasing Hormone; 4F86W47BR6 / Raloxifene Hydrochloride
  • [Number-of-references] 53
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22. Jaeckle KA: Neurologic manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol; 2010 Jul;30(3):254-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas.
  • In previously treated patients, the main differential diagnostic consideration is radiation-induced plexopathy, which can be difficult to distinguish from tumor plexopathy.
  • Treatment of metastatic plexopathy has included surgical resection of tumor in selected cases, radiotherapy to the plexus, systemic chemotherapy, interventional pain management procedures, and symptomatic treatment.
  • [MeSH-major] Neoplasms / complications. Nervous System Diseases / etiology. Peripheral Nervous System Diseases / etiology. Radiation Injuries / complications

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  • [Copyright] Thieme Medical Publishers.
  • (PMID = 20577932.001).
  • [ISSN] 1098-9021
  • [Journal-full-title] Seminars in neurology
  • [ISO-abbreviation] Semin Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Gachiani J, Kim D, Nelson A, Kline D: Surgical management of malignant peripheral nerve sheath tumors. Neurosurg Focus; 2007;22(6):E13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: The aim of this study was to describe the presentation of patients harboring soft tissue sarcomas involving the nerves, most of which were malignant peripheral nerve sheath tumors (MPNSTs), and provide an algorithm for their treatment.
  • METHODS: The authors retrospectively analyzed data on 43 surgically treated soft tissue sarcomas involving the nerves, 34 (79%) of which were MPNSTs.
  • Tumor classifications are presented, together with patient numbers, locations of MPNSTs, surgical techniques, and adjunctive treatments.
  • Most of these lesions (19 MPNSTs [56%]) were located in the brachial plexus, whereas the rest were located on other major nerves.
  • Neurofibromatosis Type 1-associated tumors (12 lesions) represented 35% of the total number of MPNSTs.
  • The role of chemotherapy is still being defined.
  • [MeSH-major] Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Disease Management. Humans. Middle Aged. Retrospective Studies

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  • (PMID = 17613204.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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24. Mok TS, Kwan WH, Yeo WM, Chan AT, Chan EC, Chak K, Chow DL, Lo C, Leung TW, Teo PM: Clinical outcomes of post-operative locoregional radiotherapy in pre-menopausal and post-menopausal Chinese women with breast cancer. Radiother Oncol; 2000 Mar;54(3):201-8
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  • The patients were stratified according to tumor size, menopausal and LN status.
  • Distribution of tumor size and LN status of the two groups was similar.
  • Long-term toxicities included skin atrophy (0.3%), telangectasia (3.3%), pneumonitis (2.8%) and brachial plexus palsy (1.3%).
  • Limited use of adjuvant system chemotherapy may account, at least in part, for this finding.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Postmenopause. Premenopause
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. China. Combined Modality Therapy. Female. Humans. Lymphatic Metastasis. Mastectomy. Middle Aged. Neoplasm Recurrence, Local. Radiation Injuries. Retrospective Studies. Survival Rate

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  • (PMID = 10738077.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] IRELAND
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25. Ball C, Thomson KR, Kavnoudias H: Irreversible electroporation: a new challenge in "out of operating theater" anesthesia. Anesth Analg; 2010 May 1;110(5):1305-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A clinical trial of IRE as a tumor ablation therapy was performed at our institution.
  • A pulsating direct current of 20 to 50 A and 500 to 3000 V was delivered into metastatic or primary tumors in the liver, kidney, or lung via needle electrodes inserted under computed tomography (CT) or ultrasound guidance.
  • Two patients developed positional neuropraxia because of the extended arm position requested for CT scanning.
  • After experimentation, we have developed a modified arm position.
  • Some patients developed self-limiting ventricular tachycardias that are now minimized by using an electrocardiogram synchronizer.
  • Three patients developed pneumothoraces as a result of the needle electrode insertion.
  • Attention to the position of the arms is required to maximize CT scan quality but minimize brachial plexus strain.
  • [MeSH-major] Electroporation / methods. Neoplasms / therapy
  • [MeSH-minor] Acid-Base Imbalance / etiology. Adult. Aged. Aged, 80 and over. Anesthesia, General. Anesthetics, Inhalation. Anesthetics, Intravenous. Arrhythmias, Cardiac / etiology. Electrocardiography. Electrodes. Electroencephalography / drug effects. Female. Humans. Hypertension / etiology. Isoflurane. Male. Middle Aged. Muscle, Skeletal / physiology. Neoplasm Metastasis / therapy. Pain, Postoperative / epidemiology. Pneumothorax / etiology. Propofol. Tomography, X-Ray Computed. Water-Electrolyte Imbalance / etiology

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  • [CommentIn] Anesth Analg. 2010 May 1;110(5):1264 [20418290.001]
  • (PMID = 20142349.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Inhalation; 0 / Anesthetics, Intravenous; CYS9AKD70P / Isoflurane; YI7VU623SF / Propofol
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26. Esch AT, Esch A, Knorr JL, Boezaart AP: Long-term ambulatory continuous nerve blocks for terminally ill patients: a case series. Pain Med; 2010 Aug;11(8):1299-302
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  • All three cases had an unfavorable coagulation status; case 2 had a prior pneumonectomy on the contralateral side and a large tumor on the ipsilateral lung of the continuous brachial plexus block.
  • RESULTS: After infusion and titration of local anesthetic doses, oral opioid medication was significantly reduced, which resulted in an improved quality of life.
  • [MeSH-major] Ambulatory Care. Nerve Block / methods. Pain / drug therapy. Terminally Ill
  • [MeSH-minor] Aged. Analgesics, Opioid / therapeutic use. Female. Humans. Male. Middle Aged. Pain Measurement

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  • (PMID = 20704678.001).
  • [ISSN] 1526-4637
  • [Journal-full-title] Pain medicine (Malden, Mass.)
  • [ISO-abbreviation] Pain Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid
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