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Items 1 to 29 of about 29
1. Suzuki K, Kobayashi M, Tokue A: [A case of advanced rhabdomyosarcoma of the spermatic cord who occurred epilepsy-like symptoms, but was completely responded to chemotherapy]. Nihon Hinyokika Gakkai Zasshi; 2004 Jul;95(5):733-7
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  • [Title] [A case of advanced rhabdomyosarcoma of the spermatic cord who occurred epilepsy-like symptoms, but was completely responded to chemotherapy].
  • On the diagnosis of left intrascrotal tumor, left high orchiectomy with partial scrotal skin resection was performed.
  • Pathological examination of the specimen and systemic metastasis survey revealed embryonal rhabdomyosarcoma of left spermatic cord with multiple lung metastasis (Intergroup Rhabdomyosarcoma Study Group IV).
  • Systemic chemotherapy with etoposide (VP-16), cisplatin (CDDP), and ifosfamide (IFO) (VIP therapy) was started.
  • Although epilepsy-like symptoms occurred at the first course of VIP therapy, these symptoms immediately improved by diazepam administration.
  • On the other hand, his multiple lung metastasis disappeared after the second course of VIP therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Epilepsy / drug therapy. Genital Neoplasms, Male / drug therapy. Rhabdomyosarcoma / drug therapy. Spermatic Cord
  • [MeSH-minor] Adult. Anticonvulsants / therapeutic use. Cisplatin / administration & dosage. Cisplatin / adverse effects. Diazepam / therapeutic use. Etoposide / administration & dosage. Etoposide / adverse effects. Humans. Ifosfamide / administration & dosage. Ifosfamide / adverse effects. Male

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  • (PMID = 15354722.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anticonvulsants; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; Q3JTX2Q7TU / Diazepam; UM20QQM95Y / Ifosfamide; ICE protocol 1
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2. Sekine Y, Ohki K, Okamoto K, Nomura M, Tomita H, Ohtake N, Suzuki K, Kurokawa K, Mashimo M, Saruki K, Morita T, Nakazato H, Yokoo H, Yamanaka H: Malignant fibrous histiocytoma of the right spermatic cord: a case report. Int J Urol; 2001 Oct;8(10):581-4
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  • [Title] Malignant fibrous histiocytoma of the right spermatic cord: a case report.
  • With a diagnosis of a right spermatic cord tumor, right high orchiectomy was performed.
  • Since an inflammatory type of malignant fibrous histiocytoma (MFH) was diagnosed from histopathological findings, chemotherapy and radiation therapy were performed as postoperative treatment.
  • Malignant fibrous histiocytoma with the primary focus of the spermatic cords is a rare disease.
  • To our knowledge, this is the 20th case of MFH of the spermatic cord in Japan (the 42nd in the world) and it is the second case of inflammatory type of MFH in Japan.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Histiocytoma, Benign Fibrous / pathology. Spermatic Cord / pathology
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Humans. Male. Middle Aged. Orchiectomy

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  • (PMID = 11737490.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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3. Segawa N, Abe H, Nishida T, Katsuoka Y: [Spermatic cord tuberculosis: a case report]. Hinyokika Kiyo; 2005 May;51(5):347-9
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  • [Title] [Spermatic cord tuberculosis: a case report].
  • A left spermatic cord tumor was suspected.
  • From these findings we diagnosed the patient with tuberculosis in spermatic cord.
  • Antituberculous chemotherapy was subsequently initiated.
  • [MeSH-major] Spermatic Cord. Tuberculosis, Male Genital / diagnosis
  • [MeSH-minor] Aged. Antitubercular Agents / therapeutic use. Humans. Male. Orchiectomy

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  • (PMID = 15977604.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antitubercular Agents
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4. Rodríguez García N, Llanes González L, Pascual Mateo C, Berenguer Sánchez A: [Spermatic cord rhabdomyosarcoma in an adult]. Arch Esp Urol; 2005 Nov;58(9):956-9

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  • [Title] [Spermatic cord rhabdomyosarcoma in an adult].
  • OBJECTIVES: To report one case of spermatic cord rabdomyosarcoma in an adult patient.
  • Pathology showed a spermatic cord rabdomyosarcoma.
  • The patient received several cycles of systemic chemotherapy.
  • CONCLUSIONS: Spermatic cord rabdomyosarcoma is a rare tumor derived from the undifferentiated mesoderm.
  • There are adjuvant treatments, the indication and use of which couldn't be included in proper protocols due to the low incidence of this tumour in adults.
  • [MeSH-major] Genital Neoplasms, Male. Rhabdomyosarcoma. Spermatic Cord

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  • (PMID = 16430046.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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5. Kostka R, Baitler T, Zachoval R, Sosna B, Palascak P: [Liposarcoma of the spermatic cord]. Prog Urol; 2006 Apr;16(2):215-7
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  • [Title] [Liposarcoma of the spermatic cord].
  • Liposarcoma of the spermatic cord is rare.
  • Value of adjuvant radiotherapy/chemotherapy remains uncertain.
  • Recurrences are frequent, owing to incomplete surgical removal of the tumor.
  • No evidence of recurrence or metastases has been noted during the 6-month and one year follow-up without any postoperative adjuvant therapy.
  • [MeSH-major] Genital Neoplasms, Male. Liposarcoma. Spermatic Cord

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  • (PMID = 16734250.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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6. Coleman J, Brennan MF, Alektiar K, Russo P: Adult spermatic cord sarcomas: management and results. Ann Surg Oncol; 2003 Jul;10(6):669-75
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  • [Title] Adult spermatic cord sarcomas: management and results.
  • BACKGROUND: We present a 20-year surgical experience with spermatic cord sarcoma, describe prognostic features, and evaluate the results of surgical and adjunctive treatments.
  • Disease-free survival was calculated, and prognostic factors such as tumor grade, size, extent of operation, and adjuvant therapy were analyzed.
  • The most common tumor types included liposarcoma (51%), leiomyosarcoma (19%), embryonal rhabdomyosarcoma (13%), and malignant fibrous histiocytoma (11%).
  • Twenty-nine (62%) patients had high-grade tumors, 21 (45%) were treated with adjuvant radiation, and 9 (19%) received chemotherapy.
  • We could not demonstrate a therapeutic effect of adjuvant radiation or chemotherapy.
  • CONCLUSIONS: We demonstrated that aggressive surgical strategies, including reoperative wide resection, significantly decrease local recurrence and may improve disease free-survival in select patients with spermatic cord sarcoma.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Sarcoma / pathology. Spermatic Cord / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Databases, Factual. Disease-Free Survival. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis

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  • (PMID = 12839852.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Ozeki Z, Kobayashi S, Machida T, Kobayashi T, Oka K, Ishizaka K, Oka T: [Alveolar rhabdomyosarcoma originating in spermatic cord: a case report]. Hinyokika Kiyo; 2004 Sep;50(9):653-5
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  • [Title] [Alveolar rhabdomyosarcoma originating in spermatic cord: a case report].
  • A thumb head-sized tumor was palpated through the skin on the left spermatic cord.
  • Tumor resection was performed because it was dissected easily apart from the left spermatic cord.
  • Radical inguinal orchiectomy with combined chemotherapy using vincristine, dactinomycin, and ifosfamide (VAI) was performed.
  • [MeSH-major] Genital Neoplasms, Male / surgery. Orchiectomy. Rhabdomyosarcoma, Alveolar / surgery. Spermatic Cord
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Dactinomycin / administration & dosage. Drug Administration Schedule. Humans. Ifosfamide / administration & dosage. Male. Vincristine / administration & dosage

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  • (PMID = 15518135.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; UM20QQM95Y / Ifosfamide
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8. Akatsuka J, Nemoto K, Hayashi T, Sasaki T, Kimata R, Tsuboi N, Ooaki Y, Kondo Y: [A case of testicular tumor with inferior vena cava thrombus]. Hinyokika Kiyo; 2010 May;56(5):281-4
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  • [Title] [A case of testicular tumor with inferior vena cava thrombus].
  • Computed tomographic scanning detected a right testicular tumor, multiple lung nodules, and inferior vena cava (IVC) thrombus.
  • After insertion of an IVC filter, high inguinal orchiectomy was performed after the first combination chemotherapy.
  • Pathological examination demonstrated an embryonal carcinoma with vascular invasion and direct tumoral extension into the right spermatic cord.
  • According to our survey, this is the 14th case of testicular tumor with IVC thrombus in Japan.
  • [MeSH-minor] Adult. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 20519928.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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9. Malizia M, Brunocilla E, Bertaccini A, Palmieri F, Vitullo G, Martorana G: Liposarcoma of the spermatic-cord: description of two clinical cases and review of the literature. Arch Ital Urol Androl; 2005 Jun;77(2):115-7
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  • [Title] Liposarcoma of the spermatic-cord: description of two clinical cases and review of the literature.
  • Spermatic cord liposarcoma is a rare tumor; currently only 161 cases are described in literature.
  • Radical surgery represents the therapy of choice whilst uncertain is the role of regional and retroperitoneal lymphadenectomy as well as the usefulness of adjuvant radiotherapy or chemotherapy.
  • In this paper we describe our experience of two cases treated at our Department between 1995 and 2002 and discuss about the clinical management of this misleading tumor in the light of the several experiences reported in literature.

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  • (PMID = 16146276.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 16
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10. Subramanian VS, Gilligan T, Klein EA: A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance. Nat Clin Pract Urol; 2008 Apr;5(4):220-3
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  • [Title] A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance.
  • A scrotal ultrasound scan showed a right testicular mass, suspicious for neoplasm.
  • The patient underwent right inguinal orchiectomy and was diagnosed with nonseminomatous germ cell tumor of the right testis, composed of yolk sac tumor, teratoma, and embryonal carcinoma with no evidence of metastatic disease.
  • He opted to remain under surveillance rather than undergo primary chemotherapy or retroperitoneal lymph node dissection for his clinical stage I disease.
  • Serologic relapse at 4 months after orchiectomy was successfully treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy.
  • DIAGNOSIS: A 1.7 cm nodule anterior to the right psoas muscle suspicious for metastatic disease that was seen on CT 16 months after orchiectomy was pathologically confirmed as recurrent mature teratoma in the spermatic cord.
  • MANAGEMENT: Bilateral nerve-sparing retroperitoneal lymph node dissection with complete excision of the right spermatic cord was performed.
  • The patient has since remained disease-free, with normal levels of serum tumor markers and no evidence of metastasis on chest X-ray and abdominal CT.
  • [MeSH-major] Genital Neoplasms, Male / therapy. Neoplasms, Germ Cell and Embryonal / surgery. Spermatic Cord / pathology. Teratoma / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chorionic Gonadotropin / blood. Disease Management. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local / therapy. Orchiectomy. alpha-Fetoproteins / analysis

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  • (PMID = 18268549.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / alpha-Fetoproteins
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11. Aparicio J, Germà JR, García del Muro X, Maroto P, Arranz JA, Sáenz A, Barnadas A, Dorca J, Gumà J, Olmos D, Bastús R, Carles J, Almenar D, Sánchez M, Paz-Ares L, Satrústegui JJ, Mellado B, Balil A, López-Brea M, Sánchez A, Second Spanish Germ Cell Cancer Cooperative Group: Risk-adapted management for patients with clinical stage I seminoma: the Second Spanish Germ Cell Cancer Cooperative Group study. J Clin Oncol; 2005 Dec 1;23(34):8717-23
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  • PURPOSE: To assess the efficacy of a risk-adapted treatment policy for patients with stage I seminoma by using universally accepted risk criteria.
  • RESULTS: Chemotherapy was well tolerated, as only 17 patients (7.9%) presented grade 3 to 4 toxicity.
  • All were located at the retroperitoneum, except for one at the spermatic cord.
  • Median tumor size was 25 mm (range, 11 to 70 mm), and median time to relapse was 9 months (range, 4 to 28 months).
  • All patients were rendered disease-free with chemotherapy (etoposide plus cisplatin).
  • The actuarial 5-year disease-free survival rate was 93.4% for patients on surveillance and 96.2% for patients treated with adjuvant chemotherapy.
  • A risk-adapted strategy is safe and feasible and should be considered an alternative to systematic approaches, such as irradiation, chemotherapy, or surveillance.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carboplatin / therapeutic use. Seminoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Chemotherapy, Adjuvant. Chorionic Gonadotropin, beta Subunit, Human / blood. Disease-Free Survival. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local / prevention & control. Neoplasm Staging. Neutropenia / chemically induced. Orchiectomy. Prospective Studies. Risk Factors. Treatment Outcome. Vomiting / chemically induced


12. Cruz Guerra NA, Clemente Ramos L, Montáns Araújo J, Linares Quevedo A, Pozo Mengual B, Allona Almagro A: [Paratesticular leiomyosarcoma: report of a new case]. Arch Esp Urol; 2002 Apr;55(3):311-4
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  • Physical examination showed a mass involving the distal right spermatic cord and was confirmed by ultrasound and CT.
  • Radical orchidectomy with high ligation of the right spermatic cord was performed.
  • Complete excision of the tumorous tissue was performed with no other adjuvant therapy.
  • CONCLUSIONS: This tumor type is uncommon.
  • Like other authors, we believe that orchifuniculectomy is the treatment of choice.
  • Furthermore, adjuvant radio or chemotherapy does not significantly influence survival in these patients.

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  • (PMID = 12068764.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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13. Tranchida P, Bayerl M, Voelpel MJ, Palutke M: Testicular ischemia due to intravascular large B-cell lymphoma: a novel presentation in an immunosuppressed individual. Int J Surg Pathol; 2003 Oct;11(4):319-24
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  • Orchiectomy identified occlusion of spermatic cord vessels by intravascular large B-cell lymphoma (IVLBL) and ischemic changes in the testis.
  • Tumor cells were positive for CD 10, CD 20, CD 30, and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) and early region RNA (EBER).
  • He was treated with the cessation of azathioprine, chemotherapy, anti-CD 20 immunotherapy, and radiotherapy.
  • Twenty months after diagnosis, he is alive with no evidence of lymphoma or hepatitis.
  • It highlights the importance of prompt diagnosis and intervention to achieve durable response.
  • That this lymphoma arose in the setting of immunosuppressive therapy introduces additional complexity relating to pathogenesis, clinical behavior, and treatment.
  • [MeSH-minor] Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Azathioprine / therapeutic use. Biomarkers, Tumor / analysis. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Epstein-Barr Virus Infections / physiopathology. Fever / etiology. Hepatitis, Autoimmune / complications. Hepatitis, Autoimmune / drug therapy. Humans. Immunosuppressive Agents / therapeutic use. In Situ Hybridization. Male. Middle Aged. Prednisone / therapeutic use. Radiotherapy. Rituximab. Spermatic Cord / blood supply. Spermatic Cord / pathology. Tumor Virus Infections / physiopathology. Vincristine / therapeutic use. Viral Matrix Proteins / metabolism

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  • (PMID = 14615832.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / Immunosuppressive Agents; 0 / Viral Matrix Proteins; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; MRK240IY2L / Azathioprine; VB0R961HZT / Prednisone; CHOP protocol
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14. Natsuizaka M, Kudo M, Suzuki M, Takano M, Tsuyuguchi M, Kawamura N, Noguchi S, Wada A, Nakata M, Ogasawara M, Kiyama Y, Asaka M, Kasai M: Diffuse large B-cell lymphoma with massive portal vein tumor thrombosis in a patient with alcoholic cirrhosis: a case report and literature review. Intern Med; 2009;48(10):805-8
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  • [Title] Diffuse large B-cell lymphoma with massive portal vein tumor thrombosis in a patient with alcoholic cirrhosis: a case report and literature review.
  • We describe a case of diffuse large B-cell lymphoma with massive portal vein tumor thrombosis in a patient with alcoholic cirrhosis.
  • The tumor was detected only in the intrahepatic portal vein and the spermatic cord by FDG-PET/CT.
  • The tumor showed complete response after six courses of the combination chemotherapy.
  • Portal vein tumor thrombosis of malignant lymphoma is extremely rare; moreover, it is possible that this is the first case of malignant lymphoma originating from the spermatic cord producing portal vein tumor thrombosis.
  • [MeSH-minor] Aged. Fluorodeoxyglucose F18. Humans. Male. Positron-Emission Tomography. Radiopharmaceuticals. Spermatic Cord / pathology. Tomography, X-Ray Computed


15. Scaroni C, Favia G, Lumachi F, Opocher G, Bonanni G, Mantero F, Armanini D: Unilateral adrenal tumor, erectile dysfunction and infertility in a patient with 21-hydroxylase deficiency: effects of glucocorticoid treatment and surgery. Exp Clin Endocrinol Diabetes; 2003 Feb;111(1):41-3
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  • [Title] Unilateral adrenal tumor, erectile dysfunction and infertility in a patient with 21-hydroxylase deficiency: effects of glucocorticoid treatment and surgery.
  • We studied a male adult patient affected by 21OHDS for infertility, after a long period of discontinuation of glucocorticoid therapy and then during resumption of treatment and 8 months after monoadrenalectomy.
  • The initial spermatic count revealed azoospermia and testicular needle aspiration showed a cytological picture consistent with prepuberty.
  • Treatment was resumed with onset of impotency, which improved after reduction of the dose of glucocorticoids.
  • The patient was monoadrenalectomised and his spermatic count increased.
  • The patient shows that corticosteroid therapy in 21OHDS should be continued lifelong to avoid adrenal hyperplasia with possible areas of autonomy and to allow regular fertility.
  • Impotence during treatment is probably due to a decrease of excessive adrenal androgens while testicular androgen production is still suppressed.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenal Hyperplasia, Congenital / therapy. Erectile Dysfunction / drug therapy. Glucocorticoids / therapeutic use. Infertility, Male / drug therapy. Steroid 21-Hydroxylase / physiology
  • [MeSH-minor] Adrenalectomy. Adult. Humans. Male. Spermatic Cord / pathology. Tomography, X-Ray Computed


16. Shimamoto K, Tanji N, Ozaw A, Sasaki T, Ikeda T, Iseda T, Yokoyama M: [Intrascrotal rhabdomyosarcoma in adult: a case report]. Nihon Hinyokika Gakkai Zasshi; 2009 May;100(4):545-9

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  • With a diagnosis of right intrascrotal tumor, the patient underwent right high orchiectomy.
  • The pathological diagnosis of pleomorphic rhabdomyosarcoma arisen from the right spermatic cord was made.
  • Computed tomography revealed a single metastasis in the para-vena cava lymph node.
  • Systemic chemotherapy with vincristine, actinomycin D, plus cyclophosphamide (VAC therapy), and etoposide plus cisplatin (EP therapy) were made according to Intergroup Rhabdomyosarcoma Study (IRS)-IV Regimen 45.
  • But the chemotherapy was ineffective and a retoroperitoneal lymphadenectomy (RPLND) was therefore performed.
  • After 3 months following RPLND, the tumor relapsed in a pelvic lymph node involved in right ureter and ileocaecal valve.
  • Resection of the tumor with ileocaecum was performed and then intraoperative radiotherapy (15 Gy) against the tumor bed was performed to ensure the curative effects.
  • After his recovery, he received a total of 6 courses of systemic chemotherapy consisting of vincristin, ifosphamide, etoposide (IRS-IV Regimen 47).
  • The patient was rigorously followed up for 42 months after the final chemotherapy, with no tumor recurrence.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Genital Neoplasms, Male / therapy. Lymph Node Excision. Orchiectomy. Radiotherapy, Adjuvant. Rhabdomyosarcoma / therapy. Scrotum
  • [MeSH-minor] Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local / therapy. Treatment Outcome

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  • (PMID = 19514277.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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17. Manuelli M, De Luca L, Iaria G, Tatangelo P, Sforza D, Perrone L, Bellini MI, Angelico R, Anselmo A, Tisone G: Conversion to rapamycin immunosuppression for malignancy after kidney transplantation. Transplant Proc; 2010 May;42(4):1314-6
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  • INTRODUCTION: Malignancies are a well-known complication of immunosuppressive therapy among renal transplant recipients, representing an important cause of long-term morbidity and mortality.
  • METHODS: Fifteen patients developed the following malignancies at a mean of 90.3 months (range = 10-252) after kidney transplantation: metastatic gastric cancer (n = 1), metastatic colon cancer (n = 1), bilateral nephrourothelioma (n = 1), skin cancer (n = 2), Kaposi's sarcoma (n = 2), posttransplant lymphoproliferative disorder (PTLD; n = 4), renal cell carcinoma T1 (n = 1), MALT lymphoma (n = 1), intramucous colon carcinoma (n = 1), liposarcoma of the spermatic cord (n = 1).
  • After the diagnosis of malignancy, the patients were switched from calcineurin inhibitor-based immunosuppression to rapamycin (monotherapy, n = 3), or associated with steroids (n = 6) or with mycophenolate mofetil (n = 6).
  • RESULTS: Both patients with metastatic cancer underwent chemotherapy but succumbed after 6 and 13 months.
  • Two patients with PTLD who underwent chemotherapy died after 12 and 36 months.
  • Renal graft function remained stable in all other patients from diagnosis throughout follow-up.
  • Nevertheless, it is difficult to assess whether tumor regression was due to rapamycin treatment or to the reduced immunosuppression.
  • [MeSH-major] Kidney Transplantation / immunology. Neoplasms / immunology. Sirolimus / therapeutic use
  • [MeSH-minor] Cell Division / drug effects. Cell Line, Tumor. Colonic Neoplasms / immunology. Colonic Neoplasms / pathology. Genital Neoplasms, Male / immunology. Genital Neoplasms, Male / pathology. Humans. Immunosuppression / methods. Immunosuppressive Agents / therapeutic use. Liposarcoma / immunology. Liposarcoma / pathology. Male. Neoplasm Metastasis. Skin Neoplasms / immunology. Skin Neoplasms / pathology. Stomach Neoplasms / immunology. Stomach Neoplasms / pathology

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  • [Copyright] Copyright (c) 2010. Published by Elsevier Inc.
  • (PMID = 20534289.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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18. Kawasaki M, Satoh Y, Nakashima K, Nishimura K, Kaneko A, Udoh K, Fujiyama C, Uozumi J: [Metachronous testicular seminoma with an interval of 14 years from the first nonseminomatous testicular tumor: a case report]. Nihon Hinyokika Gakkai Zasshi; 2009 Jan;100(1):16-21
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  • [Title] [Metachronous testicular seminoma with an interval of 14 years from the first nonseminomatous testicular tumor: a case report].
  • He had a past history of left testicular nonseminomatous germ cell tumor (NSGCT), stage IIB 14 years ago.
  • He had undergone chemotherapy with 3 courses of PEP and retroperitoneal lymphnode dissection revealing pathological CR.
  • He was diagnosed as having right testicular tumor.
  • Imaging studies and pathological studies revealed pure seminoma with spermatic cord invasion, stage I, pT3N0M0.
  • He underwent chemotherapy with 3 courses of VIP.
  • Herein we present a case of metachronous bilateral testicular germ cell tumor with a review of literatures.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Second Primary. Seminoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Male. Neoplasm Staging. Time Factors

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  • (PMID = 19198225.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 27
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19. Crespo Atín V, Padilla Nieva J, Martín Bazaco J, Llarena Ibarguren R, Pertusa Peña C: [Scrotal liposarcoma]. Arch Esp Urol; 2001 Sep;54(7):729-32
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  • OBJECTIVE: To describe an additional case of scrotal liposarcoma and its treatment, which was distinct from conventional treatment.
  • An additional case of liposarcoma is described which was treated by tumor excision without involvement of the testis.
  • The diagnosis, classification and treatment of this condition are discussed.
  • RESULTS: Liposarcoma is a very uncommon tumor and its diagnosis is based on the anatomopathological findings.
  • Treatment is by orchidectomy with high ligation of the spermatic cord.
  • However, the case described herein was treated only by resection of the tumor.
  • Chemotherapy does not appear to be useful in this type of tumor.
  • CONCLUSION: In some cases of scrotal liposarcoma, the tumor can be resected without performing orchidectomy.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Liposarcoma / diagnosis. Scrotum

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  • (PMID = 11692442.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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20. Cecchetto G, Alaggio R, Bisogno G, Virgone C, Dall'Igna P, Terenziani M, Boldrini R, D'Onofrio V, Ferrari A, Bernini G: Sex cord-stromal tumors of the testis in children. A clinicopathologic report from the Italian TREP project. J Pediatr Surg; 2010 Sep;45(9):1868-73
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  • [Title] Sex cord-stromal tumors of the testis in children. A clinicopathologic report from the Italian TREP project.
  • PURPOSE: Testicular sex cord-stromal tumors (SCSTs) are very rare in children and include a variety of neoplasms with different clinical features and biologic behavior.
  • Chemotherapy was recommended in patients with incomplete surgery or metastatic disease.
  • All patients underwent primary removal of the tumor; orchiectomy with high ligation of spermatic cord was performed in 7 and tumor enucleation in 4.
  • At histology, 4 patients had Leydig cell tumors, 4 juvenile granulosa cell tumors, 1 Sertoli cell tumor, 1 incompletely differentiated SCST, and 1 SCST with an intermediate pattern Sertoli cell tumor/mixed form.
  • They have to be considered in the differential diagnosis of testicular solid masses, taking into account that hormonal signs are present in a minority of cases.
  • [MeSH-major] Sex Cord-Gonadal Stromal Tumors / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Humans. Infant. Italy. Male. Orchiectomy. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20850634.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Calonge WM, Heitor F, Castro LP, Meruje M, Coutinho SP, Cunha C, Ochoa de Castro A: Neonatal paratesticular neuroblastoma misdiagnosed as in utero torsion of testis. J Pediatr Hematol Oncol; 2004 Oct;26(10):693-5
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  • Doppler ultrasonography findings were inconclusive, and a diagnosis of intrauterine torsion of the testis was suspected.
  • Pathologic examination clearly established the diagnosis of neuroblastoma.
  • As the tumor was classified as International Neuroblastoma Staging System stage I, no additional chemotherapy was administered.
  • The patient was tumor-free at 11 months follow-up.
  • [MeSH-major] Diagnostic Errors. Genital Neoplasms, Male / diagnosis. Neuroblastoma / diagnosis. Spermatic Cord Torsion / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Infant, Newborn. Karyotyping. Male. Phosphopyruvate Hydratase / analysis. Remission Induction. S100 Proteins / analysis. Spermatic Cord / pathology. Synaptophysin / analysis

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  • (PMID = 15454846.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Number-of-references] 7
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22. Montgomery E, Fisher C: Paratesticular liposarcoma: a clinicopathologic study. Am J Surg Pathol; 2003 Jan;27(1):40-7
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  • There were 30 paratesticular liposarcomas from men aged 41-87 years (mean 63 years; median 65 years) that involved the spermatic cord (23, 76%), testicular tunics (6, 20%), and epididymis (1, 4%).
  • One patient with WDL received radiation after his second recurrence and the myxoid/round cell liposarcoma received radiation and chemotherapy.
  • Only one example of DDL recurred, at 30 months; another patient, who refused therapy for 15 years, had a primary tumor 30 cm in diameter, displayed pulmonary metastases 1 month after excision, and died after 14 months.
  • One DDL recurred and only one of five (20%) developed metastases, but the mean follow-up for DDL was only 24 months.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Scrotum / pathology. Spermatic Cord / pathology. Testis / pathology

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  • (PMID = 12502926.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Bauer TW, Hahn SM, Spitz FR, Kachur A, Glatstein E, Fraker DL: Preliminary report of photodynamic therapy for intraperitoneal sarcomatosis. Ann Surg Oncol; 2001 Apr;8(3):254-9
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  • [Title] Preliminary report of photodynamic therapy for intraperitoneal sarcomatosis.
  • It is a condition for which there is no effective treatment.
  • Photodynamic therapy (PDT) is a cancer treatment modality that uses a photosensitizing agent and laser light to kill cells.
  • We report our preliminary Phase II clinical trial experience using PDT for the treatment of intraperitoneal sarcomatosis.
  • METHODS: From May 1997 to December 1998 eleven patients received twelve PDT treatments for intraperitoneal sarcomatosis.
  • Photofrin (PF) 2.5 mg/kg was administered intravenously 48 hours before surgical debulking to a maximum residual tumor size of less than 5 mm.
  • Light therapy was administered at a fluence of 2.5 J/cm2 of 532 nm green light to the mesentery and serosa of the small bowel and colon; 5 J/cm2 of 630 nm red light to the stomach and duodenum; 7.5 J/cm2 of red light to the surface of the liver, spleen, and diaphragms; and 10 J/cm2 of red light to the retroperitoneal gutters and pelvis.
  • Response to treatment was evaluated by abdominal CT scan at 3 and 6 months, diagnostic laparoscopy at 3 to 6 months, and clinical examination every 3 months.
  • RESULTS: Adequate tumor debulking required an omentectomy in eight patients (73%), small bowel resection in seven patients (64%), colon resection in four patients (36%), splenectomy in one patient (9%), and a left spermatic cord resection in one patient.
  • [MeSH-major] Hematoporphyrin Photoradiation / methods. Peritoneal Neoplasms / drug therapy. Sarcoma / drug therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. Dihematoporphyrin Ether / adverse effects. Dihematoporphyrin Ether / therapeutic use. Disease-Free Survival. Female. Follow-Up Studies. Humans. Laparotomy. Male. Middle Aged. Pennsylvania / epidemiology. Survival Rate

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  • (PMID = 11314943.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 97067-70-4 / Dihematoporphyrin Ether
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24. Mlika M, Chelly I, Benrhouma M, Haouet S, Horchani A, Zitouna MM, Kchir N: A Primary Testicular Diffuse Large B-cell Lymphoma Belonging to the Germinal Center B-cell-like Group. J Clin Med Res; 2010 Feb;2(1):47-9
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  • The authors report a new case of primary testicular lymphoma and highlight its diagnostic and therapeutic challenge.
  • Radiological findings consisted in multiple hypoechoic masses that corresponded in histological examination to a diffuse intratubular lymphomatous infiltration situated away from the spermatic cord, the epididymis, ductuli efferentes and rete testis.
  • The diagnosis of stage I primary testicular large B-cell lymphoma of germinal center B-cell-like group was made.
  • The patient is now treated by chemotherapy.
  • Primary testicular lymphoma is a rare tumour whose diagnosis is based on histological findings.
  • Treatment modalities consist in surgical excision, chemotherapy and radiation therapy but the accurate procedures are not standardized.
  • Factors that have been linked to more favorable outcomes include younger patient age, localized disease, presence of sclerosis at pathologic analysis, smaller tumour size, lower histological tumor grade and lack of epididymal or spermatic cord involvement.

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  • (PMID = 22457702.001).
  • [ISSN] 1918-3003
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3299176
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25. Soriano Sarrió P, Chirivella I, Navarro Fos S: [Coexistence of two germinal cell tumors, seminomatous and nonseminomatous, with an uncommon clinical presentation]. Arch Esp Urol; 2008 Jun;61(5):626-30
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  • Nevertheless, the presence of both components, seminomatous and non seminomatous, in a germ cell tumor is unusual.
  • RESULTS: A 34-year-old man presented with 3 cm supraclavicular tumor.
  • Tumor markers were negative and the biopsy performed discovered a lymph node metastasis of embryonal carcinoma of probable testicular origin.
  • Orchyectomy was performed and pathologic analysis demonstrated a tumor, 1 cm of diameter, histopathologically compatible with classical seminoma with pagetoid extension to rete testis.
  • Albuginea and spermatic cord did not present neoplastic involvement.
  • Currently the patient is being treated with chemotherapy.

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  • (PMID = 18709819.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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26. Valdevenito Sepúlveda JP, Merhe Nieva E, Valdevenito Sepúlveda R, Cuevas Toro M, Gómez Gallo A, Bermúdez Luna H, Contreras Meléndez L, Gallegos Méndez I, Gallardo Escobar J, Palma Ceppi C: [Reduced retroperitoneal lymphadenectomy for clinical stage I non seminomatous germ cell testicular cancer]. Arch Esp Urol; 2007 Apr;60(3):245-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: The best treatment of clinical stage I non-seminomatous germ cell testicular cancer (NSGCTC) is controversial.
  • The objective of this study is to analyse our experience in the treatment of this patients with radical orchiectomy and reduced retroperitoneal lymphadenectomy (RRL) as the initial treatment.
  • INCLUSION CRITERIA: retroperitoneal staging with computed tomography (CT), normal tumor markers after orchiectomy and testicular and retroperitoneal biopsy informed at our hospital.
  • The following metastatic risk factors in the testicular biopsy were checked: vascular invasion (venous and/or lymphatic), infiltration of tunica albuginea, rete testis, epididymis, and spermatic cord.
  • Average surgery time 2 hr 7 min; average dissected lymph nodes 13.
  • Chemotherapy in 7 patients (19%) a total of 18 cycles.
  • Four cases of contralateral tumor during follow-up (11%).
  • [MeSH-minor] Adult. Humans. Male. Middle Aged. Neoplasm Staging. Retroperitoneal Space. Retrospective Studies

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  • (PMID = 17601299.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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27. Suzuki K, Sai S, Kato K, Murase T: [A case of malignant lymphoma of the epididymis]. Hinyokika Kiyo; 2000 Apr;46(4):291-3
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  • The tumor originated from the epididymis and did not involve the testis or the spermatic cord.
  • Histologically, the tumor was diagnosed as a malignant lymphoma (non-Hodgkin's lymphoma, diffuse mixed cell type, B-cell type).
  • After establishment of the diagnosis of primary epididymal malignant lymphoma, 3 courses of chemotherapy (adriamycin, vincristine, cyclophosphamide, prednisolone) were performed.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols. Epididymis. Lymphoma, B-Cell / surgery. Lymphoma, Non-Hodgkin / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Humans. Male. Orchiectomy. Prednisolone / administration & dosage. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 10845166.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
  • [Number-of-references] 9
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28. Miyake Y, Kato T, Katayama K, Doi T, Oshima K, Handa R, Hoshi M, Makari Y, Oshima S, Iijima S, Kurokawa E, Kikkawa N: [A case of ascending colon carcinoma metastasized to an inguinal hernia sac]. Gan To Kagaku Ryoho; 2007 Nov;34(12):2016-8

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  • In the operation, a tumor of the inguinal hernia sac, which invaded to spermatic cord, could be found and was removed with right testis.
  • Bassini's method was performed after the resection of the inguinal tumor.
  • Histological examination revealed that the tumor was metastasis of colon carcinoma.
  • As for the advanced colon cancer, we need to mention the possibility of metastatic saccular tumor.
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Humans. Male. Middle Aged. Neoplasm Metastasis / drug therapy. Neoplasm Metastasis / pathology. Tomography, X-Ray Computed

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  • (PMID = 18219884.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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29. Boulanger E, Brière J, Gaulard P, Droz D, Oksenhendler E: HHV8-related non-Hodgkin's lymphoma of the spermatic cord in a patient with HIV-associated multicentric Castleman disease. Am J Hematol; 2003 Jan;72(1):70-1
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  • [Title] HHV8-related non-Hodgkin's lymphoma of the spermatic cord in a patient with HIV-associated multicentric Castleman disease.
  • [MeSH-major] Genital Neoplasms, Male / virology. Herpesviridae Infections / virology. Herpesvirus 8, Human / isolation & purification. Lymphoma, AIDS-Related / virology. Spermatic Cord. Tumor Virus Infections / virology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Antiretroviral Therapy, Highly Active. Cohort Studies. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Etoposide / therapeutic use. Giant Lymph Node Hyperplasia / complications. Giant Lymph Node Hyperplasia / drug therapy. Giant Lymph Node Hyperplasia / surgery. Humans. Male. Methotrexate / administration & dosage. Middle Aged. Orchiectomy. Prednisone / administration & dosage. Remission Induction. Sarcoma, Kaposi / complications. Skin Neoplasms / complications. Splenectomy. Vincristine / administration & dosage

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  • (PMID = 12508272.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate; CHOP protocol
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