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1. Lăzureanu C, Baderca F, Burlacu O, Nicodin A: Soft tissue epithelioid angiosarcoma. Rom J Morphol Embryol; 2010;51(4):787-92
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  • [Title] Soft tissue epithelioid angiosarcoma.
  • We present a case of 48-year-old male with a nine months history of right inferior thoracic (T10-T12) paravertebral mass, which became painful after a back trauma; dyspnea and hemoptysis were associated.
  • The preoperative native and with contrast substance CT revealed a tumor mass extended from the right paravertebral muscles to the diaphragmatic right pillar muscle, invading the postero-basal pleura and the posterior arches of the right XIth and 12th ribs with osteolysis.
  • Fragments of 10 cm large tumor resection specimen (striated muscle, dense connective tissue, adipose tissue, lymph nodes and intercostals nerves) were routinely processed, further immunohistochemical investigations were needed, using Dako antibodies pan-CK clone MNF116, CD34, CD20, vimentin, synaptophysin, melanoma HMB45 clone, with LSAB 2Kits system and further CK AE1÷AE3, CK7, CK20, CEA, S-100 protein, CD31, von Willebrand factor, D2-40÷podoplanin, Ki-67 antigen, with EnVision system and DAB visualization in both systems.
  • The histological and immunohistochemical aspects were indicative for soft tissue epithelioid angiosarcoma, which was misdiagnosed on frozen and HE sections as a carcinoma, because of the cohesiveness and nesting properties of the malignant cells, together with the presence of lymph node metastases.
  • The patient was discharged with adjuvant therapy indication: radiotherapy and chemotherapy.
  • The tumor locally recurred 12 months afterwards, but the patient is still alive 22 months after surgery.
  • [MeSH-major] Hemangiosarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Diagnostic Errors. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Thoracic Neoplasms / diagnosis. Thoracic Neoplasms / metabolism. Thoracic Neoplasms / pathology

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  • (PMID = 21103644.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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2. Narula MK, Gupta N, Anand R, Kapoor S: Extraosseous Ewing's sarcoma / primitive neuroectodermal tumor of the sacral nerve plexus. Indian J Radiol Imaging; 2009 Apr-Jun;19(2):151-4

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  • [Title] Extraosseous Ewing's sarcoma / primitive neuroectodermal tumor of the sacral nerve plexus.
  • We report an unusual case of Ewing's sarcoma / primitive neuroectodermal tumor (PNET) of the sacral nerve plexus in a 9-year-old boy who presented with a soft tissue swelling and severe piercing pain in the lower back region.
  • MRI of the lumbosacral spine showed a lobulated soft tissue mass with clubbed finger-like projections along the path of the sacral nerves, which had caused widening of the spinal canal and the sacral foramina (S2-S4 level).
  • The patient responded favorably to chemotherapy and radiotherapy, showing clinical and radiological improvement.

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  • [Cites] Tohoku J Exp Med. 2006 Aug;209(4):369-77 [16864960.001]
  • [Cites] Cancer. 1991 Aug 1;68(3):648-54 [2065287.001]
  • [Cites] AJNR Am J Neuroradiol. 2001 Apr;22(4):795-8 [11290502.001]
  • [Cites] Radiology. 1969 Jun;92(7):1501-9 [5799839.001]
  • [Cites] Australas Radiol. 2001 Aug;45(3):372-9 [11531770.001]
  • [Cites] Cancer. 1989 Oct 1;64(7):1548-53 [2776115.001]
  • (PMID = 19881073.001).
  • [ISSN] 1998-3808
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2765184
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3. Huang KF, Tzaan WC, Lin CY: Primary intraspinal mesenchymal chondrosarcoma: a case report and literature review. Chang Gung Med J; 2003 May;26(5):370-6
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  • Mesenchymal chondrosarcomas are rare malignant tumors of the bone and soft tissue.
  • Therapeutic experience with primary spinal mesenchymal chondrosarcomas is also extremely limited.
  • We report on a case of a 21-year-old man with back pain and bilateral progressive weakness and numbness of the lower extremities.
  • A T1-weighted magnetic resonance image revealed a hypointense tumor located at the T8 level.
  • The tumor was completely excised through a posterior approach.
  • Microscopic examination and immunohistochemical studies confirmed the diagnosis of mesenchymal chondrosarcoma.
  • Spinal irradiation and chemotherapy were also administered for prevention of local recurrence and metastasis.
  • Herein, we review the 22 cases of primary intraspinal mesenchymal chondrosarcomas in the literature and discuss their clinical presentations, pathology, imaging studies, treatments, and outcomes.

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  • (PMID = 12934855.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 18
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4. Tsuchiya H, Yamamoto N, Asada N, Terasaki T, Kanazawa Y, Takanaka T, Nishijima H, Tomita K: Caffeine-potentiated radiochemotherapy and function-saving surgery for high-grade soft tissue sarcoma. Anticancer Res; 2000 May-Jun;20(3B):2137-43
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  • [Title] Caffeine-potentiated radiochemotherapy and function-saving surgery for high-grade soft tissue sarcoma.
  • Caffeine, which has a DNA-repair inhibiting effect, enhances the cytocidal effects of anticancer drugs and radiation.
  • We present a preliminary report on the results of a new treatment, "radiochemotherapy combined with caffeine" (K3 protocol), for high-grade soft tissue sarcomas.
  • Seventeen patients with various high-grade soft tissue sarcomas were included in this study.
  • Preoperatively, three to five courses of intra-arterial chemotherapy using cisplatin, caffeine and doxorubicin after radiation therapy were administered.
  • Following the preoperative therapy, function-saving surgery was performed for all cases.
  • The histological response for radiochemotherapy was better than that for chemotherapy alone, that is, total tumor necrosis was identified in six patients and over 90% necrosis in another six.
  • There was no local tumor recurrence.
  • These preliminary findings suggest that caffeine-potentiated radiochemotherapy contributed to a satisfactory local response and the success of function-saving surgery for high-grade soft tissue sarcomas.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Caffeine / therapeutic use. Extremities / surgery. Premedication. Radiation-Sensitizing Agents / therapeutic use. Radiotherapy, Adjuvant. Sarcoma / radiotherapy. Soft Tissue Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Back / surgery. Chemotherapy, Adjuvant. Child. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. DNA Repair / drug effects. Disease Progression. Doxorubicin / administration & dosage. Doxorubicin / adverse effects. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Injections, Intra-Arterial. Male. Middle Aged. Necrosis. Neoplasm Recurrence, Local. Prospective Studies. Remission Induction. Sleep Initiation and Maintenance Disorders / chemically induced. Treatment Outcome

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  • (PMID = 10928167.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] GREECE
  • [Chemical-registry-number] 0 / Radiation-Sensitizing Agents; 3G6A5W338E / Caffeine; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin
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5. López Almaraz R, Villafruela Alvarez C, Rodríguez Luis J, Doménech Martínez E: [Neonatal neoplasms: a single-centre experience]. An Pediatr (Barc); 2006 Dec;65(6):529-35

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  • [Transliterated title] Neoplasias neonatales: experiencia de un centro.
  • OBJECTIVES: To describe the neoplasms diagnosed and treated in newborns (</= 28 days of life) in the Hospital Universitario de Canarias and their association with congenital abnormalities and to evaluate prenatal diagnosis of these tumors.
  • The variables analyzed were the percentage of neonatal neoplasms among the total number of cancer cases in children aged less than 14 years, their incidence among all the newborns in our hospital, sex, year of diagnosis, age at clinical diagnosis, the presence or absence of prenatal diagnosis, type of tumor (histologic diagnosis), association with syndromes or other congenital anomalies, treatment, and long-term outcome.
  • Males accounted for 43.8 % and females for 56.2 %, with a mean age at diagnosis of 5.5 days (range 1-28 days).
  • Five neonates (31.2 %) had a prenatal diagnosis, 60 % of which were made in the last 7 years of the study period.
  • Histologic diagnoses were neuroblastoma (n = 5; 31.2 %), teratoma/ germ cell tumor (n = 4; 25 %), soft tissue sarcoma (one fibrosarcoma of the thigh and two hemangiopericytoma of the back and heart; 18.8 %), and one case each of mesoblastic nephroma, cerebral tumor (ependymoblastoma), melanoma (associated with giant congenital melanocytic nevi), and acute leukemia (associated with Down syndrome).
  • Treatment consisted of surgery alone (n = 10; 62.5 %) and surgery plus chemotherapy (n = 5; 31.2 %); one patient received no treatment.
  • In the last 7 years, the prenatal diagnosis of these entities has improved.
  • Most of the neoplasms responded to therapy, mainly surgery, and long-term outcome was favorable.

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  • [CommentIn] An Pediatr (Barc). 2007 Jul;67(1):85-6 [17663916.001]
  • (PMID = 17194321.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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6. Tanaka H, Kondo E, Kawato H, Kikukawa T, Toyoda N: Aortitis during intraarterial chemotherapy for cervical cancer. Int J Clin Oncol; 2002 Feb;7(1):62-5
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  • [Title] Aortitis during intraarterial chemotherapy for cervical cancer.
  • A 76-year-old woman with stage IIb cervical cancer with a bulky tumor experienced aortitis during continuous intraarterial cisplatin-based chemotherapy.
  • The chemotherapy was administered through a catheter tip placed in the aorta abdominalis, utilizing an external infusion pump.
  • During the third course of chemotherapy, she complained of left-sided lower back pain and moderate fever was observed.
  • Elevated white blood cell count (WBC) and C-reactive protein (CRP) level were noted, and an abdominal X-ray and urgent computed tomography (CT) were performed.
  • At this level of the aortic wall, soft tissue density surrounded the aorta completely.
  • Aortitis caused by the intraarterial chemotherapy, was strongly suspected.
  • It was thought that the maldistribution of drugs and changes in the drug flow occurred due to the vertebral height movement of the catheter tip against the aortic blood flow, and there, flow to the vasa vasorum may have occurred.
  • Chemical vasculitis of the vasa vasorum due to the anticancer drugs was strongly suspected as a contributing factor of the aortitis.
  • Because of the long-term use of an intraarterial catheter, the maldistribution of drugs and changes in the drug flow occurred physically and biologically during the course of the chemotherapy.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Aortitis / diagnosis. Carcinoma, Squamous Cell / drug therapy. Catheterization / adverse effects. Cisplatin / administration & dosage. Uterine Cervical Neoplasms / drug therapy
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Infusions, Intra-Arterial / adverse effects. Magnetic Resonance Imaging. Neoplasm Staging. Tomography, X-Ray Computed


7. Vijay K, Venkateswaran K, Shetty AP, Rajasekaran S: Spinal extra-dural metastasis from Merkel cell carcinoma: a rare cause of paraplegia. Eur Spine J; 2008 Sep;17 Suppl 2:S267-70
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  • A 57-year-old lady presented with a breast lump, multiple truncal skin swellings, low back pain and rapidly progressive paraplegia.
  • MRI showed multiple epidural soft tissue masses causing neural compression.
  • Posterior decompression and tumor debulking at all three sites of neural compression was performed.
  • Histopathology of the epidural tumor was consistent with MCC and the diagnosis was confirmed by immuno-histochemistry staining for cytokeratin-20.
  • She was started on chemotherapy and radiotherapy.
  • One month after diagnosis she died due to extensive metastasis.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy. Breast Neoplasms / secondary. Decompression, Surgical. Disease Progression. Fatal Outcome. Female. Humans. Keratin-20 / analysis. Keratin-20 / metabolism. Magnetic Resonance Imaging. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / therapy. Neurosurgical Procedures. Treatment Failure

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  • [Cites] Radiat Oncol Investig. 1998;6(5):233-9 [9822170.001]
  • [Cites] Br J Dermatol. 1997 Oct;137(4):637-41 [9390346.001]
  • [Cites] W V Med J. 1999 May-Jun;95(3):127-9 [10352571.001]
  • [Cites] Magn Reson Imaging. 2004 Nov;22(9):1340 [15607111.001]
  • [Cites] J Surg Oncol. 2005 Jan 1;89(1):1-4 [15611998.001]
  • [Cites] South Med J. 2000 Mar;93(3):340-5 [10728530.001]
  • [Cites] J Clin Oncol. 2000 Jun;18(12):2493-9 [10856110.001]
  • [Cites] Magn Reson Imaging. 2000 Oct;18(8):1039-42 [11121710.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2001 Feb;127(2):149-54 [11177031.001]
  • [Cites] Ann Surg Oncol. 2001 Apr;8(3):204-8 [11314935.001]
  • [Cites] Neurol Med Chir (Tokyo). 2002 Feb;42(2):78-80 [11944594.001]
  • [Cites] Transplant Proc. 2002 Aug;34(5):1780-1 [12176573.001]
  • [Cites] Anticancer Res. 2003 Jul-Aug;23(4):3379-96 [12926079.001]
  • [Cites] J Am Acad Dermatol. 2003 Nov;49(5):832-41 [14576661.001]
  • [Cites] Arch Dermatol. 2003 Dec;139(12):1587-90 [14676075.001]
  • [Cites] Arch Dermatol. 1972 Jan;105(1):107-10 [5009611.001]
  • [Cites] Cancer. 1983 Jul 15;52(2):238-45 [6344978.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1988 Jun;14(6):1077-84 [3384714.001]
  • [Cites] Arch Dermatol. 1989 Aug;125(8):1096-100 [2757407.001]
  • [Cites] Plast Reconstr Surg. 1990 Aug;86(2):347-51 [2367585.001]
  • [Cites] Arch Surg. 1991 Dec;126(12):1514-9 [1842182.001]
  • [Cites] J Neurooncol. 1994;22(3):231-4 [7760100.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jul 30;32(5):1401-7 [7635780.001]
  • [Cites] Am Surg. 1997 May;63(5):450-4 [9128236.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 1999 Feb;8(2):153-8 [10067813.001]
  • (PMID = 18057968.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-20
  • [Other-IDs] NLM/ PMC2525916
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8. Liu JK, Kan P, Schmidt MH: Diffuse large B-cell lymphoma presenting as a sacral tumor. Report of two cases. Neurosurg Focus; 2003 Aug 15;15(2):E10
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  • [Title] Diffuse large B-cell lymphoma presenting as a sacral tumor. Report of two cases.
  • The authors describe two patients with diffuse large B-cell lymphomas presenting as a sacral tumor.
  • In the first case a 52-year-old man presented with progressive back pain, bilateral radicular pain, and saddle block anesthesia secondary to a lytic, expansile soft-tissue mass.
  • In the second case a 64-year-old man presented with left-sided radicular pain, paresthesias, and progressive weakness due to a lytic soft-tissue mass in the left sacral ala extending into the left L-5 and S-1 foramina.
  • In both cases, an open biopsy procedure was performed after nondiagnostic examination of needle biopsy samples.
  • In the first case the disease was classified as Stage IAE, and the patient subsequently underwent four cycles of cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP)- and rituximab-based chemotherapy followed by consolidation radiotherapy.
  • In the second case the disease was also classified as Stage IAE, and the patient underwent CHOP-based chemotherapy and consolidation radiotherapy.
  • Lymphoma should be considered in the differential diagnosis of sacral tumors.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Large B-Cell, Diffuse / pathology. Sacrum / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Biopsy. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Diagnosis, Differential. Doxorubicin / administration & dosage. Humans. Laminectomy. Low Back Pain / etiology. Magnetic Resonance Imaging. Male. Melanoma. Middle Aged. Neoplasm, Residual. Neoplasms, Multiple Primary. Prednisone / administration & dosage. Radiotherapy, Adjuvant. Reflex, Abnormal. Rituximab. Tomography, X-Ray Computed. Urinary Retention / etiology. Vincristine / administration & dosage

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  • (PMID = 15350041.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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9. Antonescu CR, Rosenblum MK, Pereira P, Nascimento AG, Woodruff JM: Sclerosing epithelioid fibrosarcoma: a study of 16 cases and confirmation of a clinicopathologically distinct tumor. Am J Surg Pathol; 2001 Jun;25(6):699-709
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing epithelioid fibrosarcoma: a study of 16 cases and confirmation of a clinicopathologically distinct tumor.
  • Sclerosing epithelioid fibrosarcoma (SEF) is an uncommon tumor of deep soft tissues, originally described in 1995 by Meis-Kindblom et al.
  • The group consisted of six male and 10 female patients (age range, 14-55 years; mean age, 40 years), and the tumors were located in a limb or limb girdle (n = 7), base of the penis (n = 1), back or chest wall (n = 3), and head and neck (n = 5).
  • Tumor size ranged from 3.7 to 22 cm (mean, 8.9 cm).
  • The only consistent immunohistochemical finding was a strong, diffuse reactivity of tumor cells for vimentin.
  • Bone invasion and tumor necrosis, features not reported before, were found in six cases each.
  • Treatment consisted of intralesional excision (n = 2), attempted wide local excision (n = 11), and amputation (n = 3), with either adjuvant radiation therapy (n = 9) or chemotherapy (n = 3).
  • Eight patients (57%) died of disease 16 to 86 months after diagnosis.
  • SEF shares some pathologic features with two other fibrosing fibrosarcomas, low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes, but in the authors' experience behaves clinically as a fully malignant sarcoma.
  • [MeSH-major] Fibrosarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 11395547.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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10. Cai X, Gray PJ Jr, Von Hoff DD: DNA minor groove binders: back in the groove. Cancer Treat Rev; 2009 Aug;35(5):437-50
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  • [Title] DNA minor groove binders: back in the groove.
  • With recent approval of the minor groove binding agent trabectidin in Europe for the treatment of patients with soft tissue sarcomas, there has been renewed interest in minor groove binders.
  • These agents have demonstrable anti-tumor activity against a wide variety of tumor types including leukemias, sarcomas, melanomas, breast and ovarian cancers.
  • Applying these agents according to a particular tumor's context of vulnerability might reveal previously unconsidered applications for this diverse class of agents.
  • This review provides a look at how minor groove binding agents have progressed from the lab through the clinic with particular emphasis on identifying the contexts of vulnerabilities of patient tumors which increase the effectiveness of these drugs.
  • [MeSH-major] Antineoplastic Agents / chemistry. Antineoplastic Agents / pharmacology. DNA / drug effects. Neoplasms / drug therapy

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  • (PMID = 19328629.001).
  • [ISSN] 1532-1967
  • [Journal-full-title] Cancer treatment reviews
  • [ISO-abbreviation] Cancer Treat. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 9007-49-2 / DNA
  • [Number-of-references] 97
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11. Braumann C, Jacobi CA, Rogalla S, Menenakos C, Fuehrer K, Trefzer U, Hofmann M: The tumor suppressive reagent taurolidine inhibits growth of malignant melanoma--a mouse model. J Surg Res; 2007 Dec;143(2):372-8
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  • [Title] The tumor suppressive reagent taurolidine inhibits growth of malignant melanoma--a mouse model.
  • BACKGROUND: The tumor suppressive agent taurolidine (TRD) inhibits tumor growth of more than 30 cell lines in vitro and reduces tumor load in early and advanced stages of neoplastic disease in animals.
  • METHODS: After general anesthesia, a midline laparotomy was performed and 1.5 million malignant melanoma cells (B78-D14) were applied in the spleen and 1 million cells at the back (C57BL/6).
  • On day 28, all animals were sacrificed and the total tumor weight and the number of metastatic lesions were determined by two investigators blinded for randomization.
  • RESULTS: The i.p. therapy caused a dose-dependent inhibition of total tumor growth (P = 0.003) and i.p. tumor growth (P = < 0.001), whereas subcutaneous (s.c.) tumor growth was not affected (P = 0.132) compared with the i.p. control group.
  • The i.v. therapy reduced the total tumor growth (P = 0.013) and the s.c. tumor growth (P = 0.016), whereas the i.p. tumor load was not reduced (P = 0.122) compared with the control group.
  • Both i.p. and i.v. therapy with 3% TRD significantly decreased the total number of metastatic lesions.
  • CONCLUSIONS: The i.p. and i.v. therapies reduce total tumor weight and number of metastatic lesions of disseminated malignant melanoma in a dose-dependent fashion in mice.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Melanoma / drug therapy. Soft Tissue Neoplasms / drug therapy. Taurine / analogs & derivatives. Thiadiazines / pharmacology
  • [MeSH-minor] Animals. Body Weight. Dose-Response Relationship, Drug. Female. Injections, Intraperitoneal. Injections, Intravenous. Mice. Mice, Inbred C57BL. Neoplasm Transplantation. Subcutaneous Tissue / pathology

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  • (PMID = 17612567.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Thiadiazines; 1EQV5MLY3D / Taurine; 8OBZ1M4V3V / taurolidine
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12. Ehrig T, Billings SD, Fanburg-Smith JC: Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity? Ann Diagn Pathol; 2007 Jun;11(3):153-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity?
  • Primitive neuroectodermal tumor/Ewing sarcoma (PN/ES) is a single clinical, morphologic, and molecular small round cell tumor entity.
  • These are generally found in deep soft tissue or bone of young male patients, with poor behavior.
  • Locations included groin or thigh (4), back or shoulder (3), neck (1), chest (1), scalp (1), forehead (1), hand (1), and foot (1).
  • Nine cases with material for reverse transcription-polymerase chain reaction revealed 1 positive type 2 translocation (EWS exon 7 to Fli-1 exon 5), 4 negative, and 4 "unable to amplify."
  • Treatment was by wide excision; 9 received chemotherapy and 6 radiation.
  • Cutaneous PN/ES is a superficial round cell tumor in older women, with better prognosis than deep PN/ES.
  • [MeSH-major] Neuroectodermal Tumors / diagnosis. Neuroectodermal Tumors, Primitive / diagnosis. Sarcoma, Ewing / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD / genetics. Antigens, CD / metabolism. Cell Adhesion Molecules / genetics. Cell Adhesion Molecules / metabolism. Child. Child, Preschool. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Sex Characteristics. Vimentin / genetics. Vimentin / metabolism

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  • (PMID = 17498589.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Vimentin
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13. Hung JJ, Chou TY, Sun CH, Liu JS, Hsu WH: Primary synovial sarcoma of the posterior chest wall. Ann Thorac Surg; 2008 Jun;85(6):2120-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Synovial sarcoma is a malignant soft-tissue tumor that most commonly occurs in the extremities of young adults.
  • We present a 24-year-old man who had right back pain, chest pain, dyspnea, and intermittent fever from a huge primary synovial sarcoma of the right posterior chest wall.
  • Multimodality therapies, including surgical resection, and chemotherapy and radiation therapy were applied, but the tumor progressed rapidly and the patient died 6 months after diagnosis.
  • Prompt diagnosis and aggressive surgical resection is mandatory for primary synovial sarcoma of the chest wall because of its aggressive behavior.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Disease Progression. Humans. Male. Palliative Care. Tomography, X-Ray Computed

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  • (PMID = 18498838.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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14. Tsz-Kan T, Man-Kwong C, Shu Shang-Jen J, Ying-Lee L, Wai Man-Wah A, Hon-Shing F: Radiofrequency ablation of recurrent fibromatosis. J Vasc Interv Radiol; 2007 Jan;18(1 Pt 1):147-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Radiofrequency (RF) ablation has received increasing attention as a promising technique for treating focal malignant disease and is a safe and effective technique for tumor control.
  • The authors report a case in which RF ablation was performed in a woman with recurrent fibromatosis of the lower back who refused further surgery.
  • Satisfactory results were obtained at long-term follow-up, with no recurrence of tumor.
  • [MeSH-major] Catheter Ablation. Fibroma / therapy. Neoplasm Recurrence, Local / therapy. Soft Tissue Neoplasms / therapy. Subcutaneous Tissue / pathology
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Back. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged. Seroma / etiology. Wound Infection / drug therapy

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  • (PMID = 17296717.001).
  • [ISSN] 1051-0443
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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15. Biswas A, Puri T, Goyal S, Gupta R, Eesa M, Julka PK, Rath GK: Spinal intradural primary germ cell tumour--review of literature and case report. Acta Neurochir (Wien); 2009 Mar;151(3):277-84

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  • [Title] Spinal intradural primary germ cell tumour--review of literature and case report.
  • BACKGROUND: Primary spinal cord germ cell tumour is a rare tumour.
  • We herein review the tumour characteristics, associated risk factors, treatment policy, and patterns of failure of primary intradural germ cell tumour.
  • METHOD: We conducted a PUBMED search using a combination of keywords such as "spinal germ cell tumor," "germinoma," "extradural," "intradural," "intramedullary," "extramedullary," and identified 19 cases of primary spinal germ cell tumour.
  • Clinical features, pathologic characteristics, and treatment details of these patients including status at follow-up were noted from respective case reports.
  • We also describe a case of a young Indian patient of intradural extramedullary germ cell tumour treated with a combination of surgery, chemotherapy, and radiotherapy.
  • The most common location of the tumour was thoracic (40%).
  • Most patients were treated with a combination of surgery, radiation therapy, and systemic chemotherapy.
  • The illustrative case was a 28-year male, presenting with pain in lower back and both lower limbs for 2 months.
  • Magnetic resonance imaging spine showed an inhomogeneous hyperintense soft tissue mass at L(2)-L(4) spinal level.
  • He was treated with complete surgical excision and four cycles of chemotherapy with BEP regimen following a histological diagnosis of non-seminomatous germ cell tumour.
  • CONCLUSION: Limited surgery followed by upfront radiation therapy and adjuvant chemotherapy is the optimal management of this rare group of tumour.
  • Omission of radiation therapy from the treatment armamentarium might engender local recurrence and spinal dissemination at first failure.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / therapy. Spinal Cord / pathology. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Chorionic Gonadotropin, beta Subunit, Human / analysis. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Decompression, Surgical. Disease Progression. Fatal Outcome. Humans. Lumbar Vertebrae. Magnetic Resonance Imaging. Male. Myelitis, Transverse / etiology. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / radiotherapy. Neurosurgical Procedures. Radiotherapy. Subarachnoid Space / pathology. Subarachnoid Space / surgery

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  • [CommentIn] Acta Neurochir (Wien). 2009 Aug;151(8):983-4 [19337687.001]
  • (PMID = 19240975.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
  • [Number-of-references] 41
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16. Ruhland B, Dittmer C, Thill M, Diedrich K, Fischer D: Metastasized hemangiopericytoma of the breast: a rare case. Arch Gynecol Obstet; 2009 Sep;280(3):491-4
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  • Liposarcoma, leiomyosarcoma, rhabdomyosarcoma, as well as hemangiopericytoma, are part of the soft tissue sarcoma group.
  • Little is known about the progress, prognosis and dissemination of this infrequent tumor entity.
  • We present the case of a woman, who received primary diagnosis of a malignant hemangiopericytoma of the left breast.
  • She underwent a mastectomy with an axillary lymph node sampling (stage pT3 pN0 cM0), as adjuvant therapy was not mandatory.
  • Eight months after diagnosis, the patient presented with lumbar back pain, gluteal pain and right accentuated adynamia in both legs because of a disseminated osseous metastasis.
  • Two months after initiation of chemotherapy the patient died.
  • Diagnostic criteria and treatment principles in the metastatic situation are presented in addition to the literature to give a review about this rare malignancy.
  • [MeSH-major] Bone Neoplasms / secondary. Breast Neoplasms / pathology. Hemangiopericytoma / secondary. Hemangiopericytoma / therapy
  • [MeSH-minor] Aged. Axilla. Fatal Outcome. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Mastectomy. Neoplasm Metastasis

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  • (PMID = 19169699.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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17. Uchida K, Kobayashi S, Yayama T, Muramatsu J, Kurokawa T, Imamura Y, Baba H: Metastatic involvement of sacral nerve roots from uterine carcinoma: a case report. Spine J; 2008 Sep-Oct;8(5):849-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: We describe the clinical presentation and diagnosis of metastatic involvement of sacral nerve roots retrogradely from uterine carcinoma, and its implication for spine surgeons, along with a brief review of literature.
  • METHODS: A 39-year-old woman with history of uterine cancer presented with persistent severe low back pain, intractable radicular pain, and neurological deficit in the right lower extremity.
  • She had undergone radical hysterectomy for uterine adenocarcinoma 4 years ago followed by chemotherapy and radiotherapy.
  • Magnetic resonance imaging (MRI) revealed abnormal swelling of the S1 and S2 nerve roots along with a soft-tissue mass in the retroperitoneal space.
  • RESULTS: The patient underwent surgical rhizotomy and histology of the roots revealed metastatic tumor in the dorsal root ganglion.

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  • (PMID = 17981096.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Nishiyama N, Nakatani S, Inoue K, Katoh T, Kinoshita H: Primary lymphoma of bone originating in a rib. Jpn J Thorac Cardiovasc Surg; 2000 Mar;48(3):180-3
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  • A 60-year-old man complaining of right chest and back pain consulted our hospital for further examination.
  • Chest X-ray and computed tomogram revealed osteolysis and a surrounding soft tissue mass in the sixth right rib.
  • An ultrasonically-guided needle biopsy of the tumor was performed, and histologic examination indicated the dense proliferation of similar-sized atypical cells with nucleoli and an irregular nuclear border.
  • A diagnosis of diffuse, medium-sized non-Hodgkin's lymphoma, B-cell type was made.
  • En block resection of the tumor and chest wall was performed.
  • Macroscopically, the tumor measured 7.5 x 4.8 x 3.0 cm in diameter, and the histologic findings were similar to those of the preoperative needle biopsy.
  • Unfortunately, postoperative treatment with radiation therapy and chemotherapy was ultimately unsuccessful, and a local recurrence and metastatic lesions appeared in the stomach and para-aortic abdominal lymph nodes 7 months after the first symptom appeared.
  • Surgery was chosen as the initial therapy as it was considered that a rib resection would not result in serious respiratory compromise and the complete resection of the tumor would be superior to radiation therapy for local control.
  • However, it is a systemic disease and a more effective therapeutic strategy should be developed.

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  • (PMID = 10793497.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
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19. Hung GD, Chen YH, Chen DY, Lan JL: Subcutaneous panniculitis-like T-cell lymphoma presenting with hemophagocytic lymphohistiocytosis and skin lesions with characteristic high-resolution ultrasonographic findings. Clin Rheumatol; 2007 May;26(5):775-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an unusual type of skin lymphoma, characterized by subcutaneous soft tissue infiltration with pleomorphic T-cells and benign macrophages that mimic panniculitis.
  • Hemophagocytic lymphohistiocytosis is a rare but potentially fatal disorder which is thought to result from uncontrolled activation and proliferation of T-cells and excessive activation of macrophages.
  • The fever subsided and the ferritin level declined to normal after treatment with oral steroid and etoposide.
  • However, nonremitting high fever and panniculitis-like skin lesions over her back, arm, lower abdominal wall, and bilateral pretibial regions developed 1 month later.
  • The immunochemical stain showed a T-cell lineage of tumor cells.
  • SPTCL was diagnosed and the skin lesions subsided gradually after treatment with anthracycline-based combination chemotherapy.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Panniculitis / diagnosis. Ultrasonography


20. Morita K, Zywietz F, Kakinuma K, Tanaka R, Katoh M: Efficacy of doxorubicin thermosensitive liposomes (40 degrees C) and local hyperthermia on rat rhabdomyosarcoma. Oncol Rep; 2008 Aug;20(2):365-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumor response and systemic toxicity were evaluated by comparing to free doxorubicin (Free Dox) with or without hyperthermia.
  • Tumors were heated with infrared-A-radiation and drugs were infused intravenously after preheating the tumors followed by a further 60 min of heating at 42.5 degrees C.
  • Recorded temperatures at various locations in the tumors indicated that all intratumoral temperatures, especially at the back rim, were definitely >40 degrees C.
  • After single doses, tumor growth was further inhibited by Dox-Lip+HT compared to Free Dox+HT or Free Dox alone.
  • Repeated treatments with Dox-Lip+HT (2x2.5 mg/kg+HT/2 weeks) resulted in a statistically significant tumor growth delay and was associated with a much lower systemic toxicity.
  • Uptake studies of drugs in blood, tumor and normal tissues showed that Dox-liposomes (40 degrees C) are long circulating liposomes in the blood.
  • However, the enhanced tumor response did not correlate with an increased uptake of Dox-Lip+HT in the tumor.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Doxorubicin / therapeutic use. Hyperthermia, Induced. Rhabdomyosarcoma / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Animals. Body Weight / drug effects. Combined Modality Therapy. Disease Models, Animal. Drug Carriers. Liposomes. Male. Rats. Rats, Inbred Strains. Survival Rate

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  • (PMID = 18636199.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Drug Carriers; 0 / Liposomes; 80168379AG / Doxorubicin
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