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Items 1 to 24 of about 24
1. Erol FS, Ozveren MF, Ozercan IH, Topsakal C, Akdemir I: Primary Ewing's sarcoma of the occipital bone--case report. Neurol Med Chir (Tokyo); 2001 Apr;41(4):206-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary Ewing's sarcoma of the occipital bone--case report.
  • The tumor was surgically removed, and the patient underwent radiotherapy and chemotherapy.
  • Fourteen months after surgery there has been no recurrence of the tumor.
  • Cranial primary Ewing's tumor has a good prognosis after radical surgery and adjuvant therapy.
  • [MeSH-major] Occipital Bone. Sarcoma, Ewing / diagnosis. Skull Neoplasms / diagnosis. Temporal Bone
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. Craniotomy. Female. Humans. Prognosis. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 11381680.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Isaka T, Maruno M, Suzuki T, Sato M, Yoshimine T: Skull metastases from atypical pulmonary carcinoid tumor in a 19-year-old man. Neurol Med Chir (Tokyo); 2006 Dec;46(12):609-13
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  • [Title] Skull metastases from atypical pulmonary carcinoid tumor in a 19-year-old man.
  • A 19-year-old man presented with a rare skull metastasis from atypical pulmonary carcinoid tumor (APCT) manifesting as headache, diplopia, and cough.
  • Head magnetic resonance imaging showed a skull base tumor extending from the posterior clinoid process to the clivus, and calvarial tumors in the right temporal and occipital bones.
  • Chest and abdominal computed tomography showed a round tumor, 4 cm in diameter, in the lower lobe of the right lung and multiple small tumors in the liver.
  • Surgery for the calvarial tumor in the right temporal bone was performed on June 27, 2003.
  • The histological diagnosis was skull metastasis of neuroendocrine tumor.
  • Partial resection of the right lower lobe was performed for the lung tumor on August 22, 2003.
  • The histological diagnosis was atypical carcinoid tumor.
  • Subsequent adjuvant systematic chemotherapy was performed.
  • We must consider APCT in the differential diagnosis of pulmonary tumors in adolescents, and perform follow-up observation or treatment, including surgery, if APCT is suspected.
  • [MeSH-major] Carcinoid Tumor / secondary. Lung Neoplasms / pathology. Skull Neoplasms / secondary

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  • (PMID = 17185889.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Kanto S, Tokuyama S, Numahata K, Nakagawa H, Saito S, Arai Y: [Occult lumbar vertebral body metastasis of non-seminomatous germ cell tumor eradicated by radiation and salvage surgery 9 years after initial onset]. Nihon Hinyokika Gakkai Zasshi; 2007 May;98(4):634-7
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  • [Title] [Occult lumbar vertebral body metastasis of non-seminomatous germ cell tumor eradicated by radiation and salvage surgery 9 years after initial onset].
  • In this report we describe a case of late relapse non-seminomatous germ cell tumor eradicated after 9 years of initial onset.
  • A 20-year-old man complaining of recent aches, vomiting and headaches was diagnosed with right testicular tumor with solitary brain and bilateral lung metastases.
  • A right high orchiectomy was performed, followed by a right occipital osteoplastic craniotomy due to the presence of left hemiplesia and anisocoria prior to chemotherapy.
  • Pathologically, the tumors were embryonal carcinoma and yolk sac tumor.
  • The patient received 5 cycles of cisplatin-based PEP chemotherapy (cisplatin, etoposide and peplomycin) after which all the tumor markers fell to within the normal range.
  • The remaining right lung tumor was removed surgically and the remnant lesion was found to be scar tissue.
  • Four years after initial therapy, elevated serum HCG levels were detected.
  • The tumor metastasis showed only HCG elevation responsive to chemotherapy each time followed by relapse and undetectable with all kinds of imaging examinations for 5 years.
  • Finally when the tumor became chemorefractory, conventional computed tomography scan on bone window detected the occult tumor in L4 corporal body.
  • After radiation therapy the tumor was removed by total spondylectomy and there was no viable tumor cells in the specimen pathologically.
  • CT bone window photography may be sometimes useful to detect occult bone metastasis and salvage surgery combined with radiation therapy may be worth trying in patients with chemorefractory non-seminomatous germ cell tumors.
  • [MeSH-major] Lumbar Vertebrae / surgery. Neoplasms, Germ Cell and Embryonal / radiotherapy. Neoplasms, Germ Cell and Embryonal / surgery. Salvage Therapy. Spinal Neoplasms / radiotherapy. Spinal Neoplasms / surgery. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Male. Radiotherapy Dosage. Remission Induction. Tomography, X-Ray Computed

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  • (PMID = 17564107.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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4. Han X, Dong Y, Sun K, Lu Y: A huge occipital osteoblastoma accompanied with aneurysmal bone cyst in the posterior cranial fossa. Clin Neurol Neurosurg; 2008 Mar;110(3):282-5
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  • [Title] A huge occipital osteoblastoma accompanied with aneurysmal bone cyst in the posterior cranial fossa.
  • Osteoblastoma is an infrequent benign tumor and skull involvement is extremely rare.
  • The occipital bone is much less frequently involved.
  • We report an unusual case of a huge occipital osteoblastoma with aneurysmal bone cyst in the posterior cranial fossa of a 20-year-old young man.
  • MRI scan and CT three-dimensional reconstruction revealed that the tumor (approximately 8.5 cm x 6 cm x 5 cm) occupied nearly half volume of the posterior cranial fossa.
  • The tumor mass was multiloculated cystic and highly vascular.
  • Pathological examination revealed that the lesion was a benign osteoblastoma with secondary aneurysmal bone cyst (ABC).
  • Our case confirms the findings of previous investigators that if osteoblastoma is removed completely, no recurrence is expected even without adjuvant irradiation and chemotherapy.
  • [MeSH-major] Bone Cysts, Aneurysmal / pathology. Brain Neoplasms / pathology. Occipital Lobe. Osteoblastoma / pathology
  • [MeSH-minor] Aged. Brain / pathology. Cranial Fossa, Anterior / pathology. Cranial Fossa, Anterior / surgery. Humans. Magnetic Resonance Imaging. Male. Neurosurgical Procedures. Osteoblasts / pathology. Tomography, X-Ray Computed

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  • (PMID = 18055104.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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5. Kanai Y, Matsuda M, Iwanaga T, Hashimoto S, Maeda Y, Kanamaru A, Itagaki N: [Diffuse large B-cell lymphoma presenting with hypoglossal nerve palsy and great occipital neuralgia]. Rinsho Ketsueki; 2009 Feb;50(2):113-5
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  • [Title] [Diffuse large B-cell lymphoma presenting with hypoglossal nerve palsy and great occipital neuralgia].
  • A 74-year-old man was hospitalized with hypoglossal nerve paralysis and severe great occipital neuralgia.
  • Enhanced MRI of the head showed tumor on the left petrous bone, which compressed the medulla oblongata.
  • After radiation therapy to the lesion on the petrous bone, splenectomy was performed.
  • Pathological findings established a diagnosis of diffuse large B-cell lymphoma.
  • After chemotherapy consisting of rituximab and THP-COP, complete remission was achieved.
  • [MeSH-major] Hypoglossal Nerve Diseases / etiology. Lymphoma, Large B-Cell, Diffuse / complications. Neoplasms, Multiple Primary. Neuralgia / etiology. Occipital Bone / innervation. Petrous Bone. Skull Neoplasms / complications
  • [MeSH-minor] Aged. Biomarkers, Tumor / blood. Combined Modality Therapy. Humans. Male. Receptors, Interleukin-2 / blood. Remission Induction. Splenic Neoplasms / complications. Splenic Neoplasms / diagnosis. Splenic Neoplasms / therapy

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  • (PMID = 19265306.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Interleukin-2
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6. Kanazawa R, Yoshida D, Takahashi H, Matsumoto K, Teramoto A: Osteosarcoma arising from the skull--case report. Neurol Med Chir (Tokyo); 2003 Feb;43(2):88-91
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  • A 20-year-old male presented with an osteosarcoma in the right parieto-occipital bone occurring as a painless occipital lump which had rapidly enlarged in the 6 months prior to admission.
  • Gross total resection of the tumor was achieved.
  • The final histological diagnosis was osteosarcoma.
  • Adjuvant therapy may be an option in cases of incomplete excision.
  • Advances in target chemotherapy may diminish the significant morbidity associated with these lesions.
  • [MeSH-major] Osteosarcoma / diagnosis. Skull Neoplasms / diagnosis
  • [MeSH-minor] Adult. Angiography. Humans. Magnetic Resonance Imaging. Male. Meningeal Arteries / radiography. Tomography, X-Ray Computed

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  • (PMID = 12627887.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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7. Watanabe T, Fuse T, Umezu M, Yamamoto M, Demura K, Niwa Y: Radiation-induced osteosarcoma 16 years after surgery and radiation for glioma--case report. Neurol Med Chir (Tokyo); 2006 Jan;46(1):51-4
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  • A 35-year-old man developed osteosarcoma of the left parietal and occipital bones 16 years after radiotherapy for glioma in the right occipital lobe.
  • Radiotherapy of the primary neoplasm used 50 Gy administered to a localized field through two lateral ports.
  • The secondary neoplasm arose contralateral to the primary lesion but within the irradiated field.
  • The tumor had a multilocular cyst with considerable intracranial extension, and symptoms of elevated intracranial pressure were prominent early in the course.
  • After a short-lived initial remission following surgical intervention and chemotherapy, the patient deteriorated because of tumor recurrence and died 18 months after the diagnosis.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Glioma / radiotherapy. Neoplasms, Radiation-Induced / etiology. Occipital Bone. Osteosarcoma / etiology. Parietal Bone. Skull Neoplasms / etiology
  • [MeSH-minor] Adult. Humans. Male. Radiotherapy / adverse effects. Time Factors

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  • (PMID = 16434828.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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8. Delgado-López PD, Martín-Velasco V, Castilla-Díez JM, Fernández-Arconada O, Corrales-García EM, Galacho-Harnero A, Rodríguez-Salazar A, Pérez-Mies B: Metastatic meningioma to the eleventh dorsal vertebral body: total en bloc spondylectomy. Case report and review of the literature. Neurocirugia (Astur); 2006 Jun;17(3):240-9
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  • To our knowledge, this is the first description of a total en bloc spondylectomy through a posterior approach for the treatment of an intraosseous metastatic meningioma to the eleventh dorsal vertebra.
  • CASE REPORT: In March 1996, a 37 year-old male underwent surgical resection for a left occipital intraventricular benign meningioma (WHO I).
  • By the end on 2003 he developed progressively invalidating dorsolumbar pain.
  • The pathological specimen was identified as adenocarcinoma and he initiated chemotherapy.
  • Advice from a second pathologist was seeked, who suggested the diagnosis of intraosseous meningioma.
  • Workup studies failed to reveal any primary tumor.
  • In May 2004 the patient was admitted to our department and a new transpedicular biopsy confirmed the diagnosis.
  • In June 2004 he underwent T11 total en bloc spondylectomy (Tomita's procedure), fusion with bone and calcium substitute-filled stackable carbon-fiber cages, and T9 to L1 transpedicular screw fixation.
  • Hematogenous (especially venous; Batson's perivertebral plexus), linfatic and cerebrospinal fluid are the main routes involved in the spreading of the tumor.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Review Literature as Topic

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  • (PMID = 16855782.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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9. Caird J, McDermott M, Farrell M: March 2000: 5 month old boy with occipital bone mass. Brain Pathol; 2000 Apr;10(2):317-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] March 2000: 5 month old boy with occipital bone mass.
  • Microscopically, a biphasic appearance consisting of large pigmented cells arranged into tubules and small nonpigmented basophilic cells arranged into nests gave rise to a diagnosis of melanotic neuroectodermal tumour of infancy [MNETI].
  • One year after a wide local excision the patient is tumor-free and developing normally.
  • The prognosis for MNETI in general is excellent with no requirement for additional radiotherapy or chemotherapy.
  • [MeSH-major] Neuroectodermal Tumor, Melanotic / pathology. Occipital Bone / pathology. Skull Neoplasms / pathology

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  • (PMID = 10764053.001).
  • [ISSN] 1015-6305
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] SWITZERLAND
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10. Aoki Y, Kase H, Kashima K, Yahata T, Tanaka K: Placental site trophoblastic tumor presenting as subaponeurotic metastasis. Int J Gynecol Cancer; 2005 Mar-Apr;15(2):385-8
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  • [Title] Placental site trophoblastic tumor presenting as subaponeurotic metastasis.
  • Cases of metastatic placental site trophoblastic tumor (PSTT) have a very poor prognosis because these tumors tend to be less sensitive to chemotherapy than other types of gestational trophoblastic disease.
  • We describe the case of a 25-year-old woman who presented with occipital tumor and abnormal vaginal bleeding.
  • Hysterectomy, bilateral salpingo-oophorectomy, and occipital tumor removal revealed a primary PSTT in the uterus, with ovarian and occipital subaponeurotic metastases.
  • She received etoposide, methotrexate, actinomycin-D/cyclophosphamide, vincristine chemotherapy and had a complete clinical remission.
  • Fifteen months later, she had a recurrent subaponeurotic occipital tumor invading the cranium and underwent tumor removal along with cranial bone followed by local irradiation.
  • She was then treated with etoposide, cis-platinum/etoposide, methotrexate, actinomycin-D chemotherapy and again had a remission for 5 months.
  • The patient, however, had a left parietal subaponeurotic tumor, invading the dura mater, and received local irradiation.
  • Soon after, she developed left orbital bone metastasis, treated by local irradiation.
  • These bone metastases responded to the radiation completely.
  • New modalities of treatment for high-risk or metastatic PSTT need to be developed.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / secondary. Occipital Bone / pathology. Placenta Diseases / pathology. Skin Neoplasms / secondary. Trophoblastic Neoplasms / secondary. Uterine Neoplasms / pathology

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  • (PMID = 15823131.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Balasubramaniam S, Nadkarni T, Menon R, Goel A, Rajashekaran P: Primary Ewing's sarcoma of the petroclival bone. J Clin Neurosci; 2008 Jun;15(6):712-4
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  • [Title] Primary Ewing's sarcoma of the petroclival bone.
  • A 17-year-old male presented with signs of raised intracranial tension and multiple cranial nerve dysfunction.
  • Radiological imaging revealed an extradural calcified tumor involving the right petrous bone and adjacent clivus.
  • Histopathological study revealed that the tumor was Ewing's sarcoma.
  • Post-operative radio- and chemotherapy were administered.
  • [MeSH-major] Bone Neoplasms / pathology. Occipital Bone / pathology. Sarcoma, Ewing / pathology. Temporal Bone / pathology
  • [MeSH-minor] Adolescent. Humans. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray Computed / methods

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  • (PMID = 18342514.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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12. Puri A, Chandrasekharam VV, Agarwala S, Gupta AK, Bhatnagar V: Pediatric extragonadal germ cell tumor of the scalp. J Pediatr Surg; 2001 Oct;36(10):1602-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric extragonadal germ cell tumor of the scalp.
  • Extragonadal germ cell tumor of the scalp is exceedingly rare.
  • The authors report the case of a 1(1/2)-year-old boy with extragonadal germ cell tumor over the occipital region.
  • Computed tomography scan of the head showed a large, well-defined, lobulated, heterogeneously enhancing soft tissue mass lesion in the occipital region.
  • The underlying bone was normal with no evidence of intracranial extension.
  • The child was started on chemotherapy and received 4 cycles of cisplatin, etoposide, and bleomycin (PEB).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Germinoma / drug therapy. Head and Neck Neoplasms / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Combined Modality Therapy. Humans. Infant. Male

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  • [Copyright] Copyright 2001 by W.B. Saunders Company.
  • (PMID = 11584421.001).
  • [ISSN] 0022-3468
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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13. Tamura Y, Kuroiwa T, Doi A, Min KY: Thymic carcinoma presenting as cranial metastasis with intradural and extracranial extension: case report. Neurosurgery; 2004 Jan;54(1):209-11; discussion 211-2
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  • OBJECTIVE AND IMPORTANCE: Thymic carcinoma is an uncommon malignant tumor that is different from thymoma.
  • Cranial and brain metastases from this tumor are extremely rare.
  • We report a thymic carcinoma with cranial metastasis and discuss the behavior of this tumor.
  • CLINICAL PRESENTATION: A 50-year-old man presented with headache and a palpable scalp tumor.
  • Computed tomographic scans and magnetic resonance images revealed an osteolytic tumor with intradural and extracranial extension in the right occipital bone.
  • INTERVENTION: After gross total resection and histological diagnosis, further investigation revealed a primary thymic tumor in the anterior upper mediastinum and liver metastases.
  • The patient received multiple-cycle chemotherapy (cisplatin and gemcitabine) for primary and metastatic lesions.
  • CONCLUSION: Thymic carcinoma has a poor prognosis because of a high degree of malignancy, early metastasis, and delayed diagnosis.
  • Thus, treatment of a patient with this tumor calls for prompt diagnosis, surgical treatment, and optimal adjuvant therapy.
  • [MeSH-major] Carcinoma / secondary. Dura Mater / pathology. Occipital Bone / pathology. Skull Neoplasms / secondary. Thymus Neoplasms / pathology

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  • (PMID = 14683559.001).
  • [ISSN] 0148-396X
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Rodríguez-Arias CA, Lobato RD, Millán JM, Lagares A, de la Lama A, Alén JF: Parosteal osteosarcoma of the skull. Neurocirugia (Astur); 2001 Dec;12(6):521-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Parosteal osteosarcoma of the skull is a distinct surface bone tumor, with a better prognosis than conventional osteosarcoma.
  • The most common location is on the surface of the distal femur which accounts for 46-66% of the cases.
  • We describe the case of a man who developed a parosteal osteosarcoma arising from the occipital bone with extension to the parietal bone.
  • The patient was operated and had a complete tumor resection.
  • [MeSH-major] Occipital Bone / pathology. Osteosarcoma, Juxtacortical / pathology. Parietal Bone / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Cerebral Angiography. Chemotherapy, Adjuvant. Combined Modality Therapy. Craniotomy. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Osteosarcoma / diagnosis. Osteosarcoma / drug therapy. Osteosarcoma / pathology. Osteosarcoma / radiotherapy. Osteosarcoma / secondary. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 11787402.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 16
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15. De Paula AM, André N, Fernandez C, Coulibaly B, Scavarda D, Lena G, Bouvier C: Solitary, extracutaneous, skull-based juvenile xanthogranuloma. Pediatr Blood Cancer; 2010 Aug;55(2):380-2
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  • We report a case of an 18-month-old female who presented an occipital bone lesion with progressive growth.
  • Imaging studies showed a left extradural, skull-based tumor partially occupying the posterior fossa.
  • Partial surgical resection, chemotherapy, and conformational radiotherapy were used.
  • [MeSH-major] Bone Neoplasms / diagnosis. Xanthogranuloma, Juvenile / diagnosis
  • [MeSH-minor] Combined Modality Therapy. Diagnostic Imaging. Female. Humans. Infant. Skull Base. Treatment Outcome


16. Greenwood MJ, Dodds AJ, Garricik R, Rodriguez M: Posterior leukoencephalopathy in association with the tumour lysis syndrome in acute lymphoblastic leukaemia--a case with clinicopathological correlation. Leuk Lymphoma; 2003 Apr;44(4):719-21
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  • We report a case and autopsy findings of posterior leukoencephalopathy (PL) developing during induction chemotherapy for B-cell acute lymphoblastic leukaemia (B-ALL) complicated by tumour lysis syndrome.
  • PL may present with seizures, headache, altered mental status and occipital blindness, associated with transient parieto-occipital abnormalities on neuro-imaging studies.
  • It has also been reported in association with pre-eclamptic and eclamptic states, nephrotic syndrome and following liver and bone marrow transplantation.
  • Only rare cases of PL developing during treatment for haematological malignancy have been reported and to our knowledge it has not been previously reported in association with tumour lysis syndrome.
  • [MeSH-major] Neuromuscular Diseases / complications. Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications. Tumor Lysis Syndrome / complications

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  • (PMID = 12774751.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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17. Fierro MT, Marenco F, Novelli M, Fava P, Quaglino P, Bernengo MG: Long-term evolution of an untreated primary cutaneous follicle center lymphoma of the scalp. Am J Dermatopathol; 2010 Feb;32(1):91-4
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  • Among primary cutaneous B-cell lymphomas, follicle center lymphomas represent, according to the World Health Organization-European Organisation For Research and Treatment of Cancer classification, a subgroup with a favorable prognosis.
  • We describe the case of a 45-year-old man who presented with large infiltrated tumors and nodules coalescing into a wide ulcerated plaque of the scalp, extending from the frontal to the occipital region.
  • At the vertex, 2 large ulcerations were present, reaching the subcutaneous tissues and the underlying bone structures with osseus infiltration and erosion and consequent meningeal exposure.
  • Due to a refusal to treatment, the lesion progressively grew until now.
  • After 6 courses of chemotherapy (cyclophosphamide, vincristine, liposomal doxorubicin, prednisone-Rituximab), the tumor displayed an impressive complete regression with the persistence of a 4-cm occipital ulceration and underlying bone erosion.
  • This case gave us the opportunity to observe the natural development of the disease, leading to local mutilating and destroying lesions but with low tendency to systemic spread and an impressive response to chemotherapy.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Male. Middle Aged. Remission Induction. Scalp

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  • (PMID = 19915449.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. El Khorassani M, Benbrahim F, Hessissen L, Khattab M, Msefer F: [Intracerebral granulocytic sarcoma. A case report]. Neurochirurgie; 2003 May;49(2-3 Pt 1):119-23
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  • Granulocytic sarcoma is a tumor composed of proliferating myeloblastic cells, generally found in the orbit.
  • After 21 months of complete remission, he developed headache and facial palsy.
  • The CT scan visualized the presence of two frontal and occipital masses.
  • The study of the bone morrow showed medullar relapse.
  • A new medullar and cerebro-meningeal remission was obtained with chemotherapy and radiotherapy.
  • CSF and the bone marrow studies can help avoid stereotaxic biopsy can be avoided in this type of tumor
  • [MeSH-minor] Bone Marrow / pathology. Child. Combined Modality Therapy. Contrast Media. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 12746729.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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19. Hirayama Y, Sakamaki S, Tsuji Y, Sagawa T, Chiba H, Matsunaga T, Kato J, Niitsu Y: [IgM type multiple myeloma expressing various surface adhesion molecules and demonstrating an aggressive clinical course]. Rinsho Ketsueki; 2003 Sep;44(9):957-61
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  • [Title] [IgM type multiple myeloma expressing various surface adhesion molecules and demonstrating an aggressive clinical course].
  • An occipital punched-out lesion was detected on a cranial X-ray.
  • A tumor lesion was detected on chest X-ray and computed tomography.
  • Bone marrow aspiration revealed an elevated plasma cell count.
  • Melphalan and prednisolone therapy were prescribed, their effect on the myeloma was short term, so we changed the chemotherapy to VAD (vincristine, adriamycin and dexamethasone), but this treatment had little effect.
  • The patient developed bacterial pneumonia and died.

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  • (PMID = 14577317.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / Immunoglobulin M
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20. Bose B: Primary osteogenic sarcoma of the skull. Surg Neurol; 2002 Sep-Oct;58(3-4):234-9; discussion 239-40
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  • BACKGROUND: An osteogenic sarcoma of the skull is rare, particularly as a primary tumor.
  • A computed tomography scan revealed a large mass, 12 cm x 7 cm, involving the scalp extending from the right temporal region to the vertex.
  • The MRI showed marked vascularity and neovascularity of the tumor.
  • The patient subsequently underwent surgery for embolization of the right occipital and superficial temporal arteries and removal of the mass.
  • CONCLUSION: We review the literature of reported cases of primary osteogenic sarcomas of the skull to discuss the common clinical presentation, evaluation methods, and recommended treatment plans.
  • [MeSH-major] Osteosarcoma / surgery. Parietal Bone / surgery. Skull Neoplasms / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Cements. Chemotherapy, Adjuvant. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / surgery. Neovascularization, Pathologic / diagnosis. Prosthesis Implantation. Tomography, X-Ray Computed

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  • (PMID = 12480227.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements
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21. Cecchi PC, Billio A, Colombetti V, Rizzo P, Ricci UM, Schwarz A: Primary high-grade B-cell lymphoma of the choroid plexus. Clin Neurol Neurosurg; 2008 Jan;110(1):75-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • She underwent a parieto-occipital craniotomy and a navigation-assisted posterior parietal transcortical approach, achieving complete removal of the intraventricular lesion originating from the choroid plexus.
  • The histological diagnosis was of high-grade diffuse large B-cell lymphoma.
  • Both an MRI scan of the entire craniospinal axis and a thoracic and abdominal CT scan showed no other neoplastic lesions; a bone marrow biopsy was normal; a final diagnosis of primary central nervous system lymphoma was made.
  • Adjuvant chemotherapy with methotrexate was administered, and at the last follow-up (26 months) our patient is clinically and radiologically disease-free.
  • Primary choroid plexus lymphoma is a very rare tumor that should be included in the differential diagnosis of intraventricular neoplasms.
  • Surgery is almost always necessary to obtain an adequate tissue sample and frequently leads to a radical removal of the lesion.
  • With a proper adjuvant therapy a relatively good outcome is observed.

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  • (PMID = 17928135.001).
  • [ISSN] 0303-8467
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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22. Laigle-Donadey F, Taillibert S, Martin-Duverneuil N, Hildebrand J, Delattre JY: Skull-base metastases. J Neurooncol; 2005 Oct;75(1):63-9

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  • Five syndromes have been described according to the metastatic site including the orbital, parasellar, middle-fossa, jugular foramen and occipital condyle syndromes.
  • Magnetic resonance imaging (MRI) is nowadays the most useful examination to establish the diagnosis but plain films, CT scans with bone windows and isotope bone scans remain helpful to demonstrate bone erosion.
  • Normal imaging studies do not exclude the diagnosis.
  • The treatment depends on the nature of the underlying tumor.
  • Radiotherapy is generally the standard treatment, while some patients with chemosensitive or hormonosensitive lesions benefit from chemotherapy or hormonotherapy and selected patients from surgical removal.

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  • (PMID = 16215817.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 92
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23. Hasan R, Marshall MC Jr, Medhi M, Arshad A, Braun A, Panageas E: Meningioma metastatic to thyroid gland. Endocr Pract; 2001 Sep-Oct;7(5):370-4
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  • RESULTS: A 49-year-old man had a meningioma in the parieto-occipital region that had spread locally to the scalp and bone by the time of surgical resection.
  • Local recurrence during the following year prompted repeated surgical resection, tumor embolization, radiotherapy, and chemotherapy.
  • Despite aggressive therapy, the tumor progressed.
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Embolization, Therapeutic. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy. Reoperation. Thyroidectomy. Tomography, X-Ray Computed

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  • (PMID = 11585373.001).
  • [ISSN] 1530-891X
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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24. Cirillo F: Metastatic paraganglioma and treatment with sunitinib: a case report. Tumori; 2010 Nov-Dec;96(6):1022-7
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  • [Title] Metastatic paraganglioma and treatment with sunitinib: a case report.
  • In this report we discuss a number of related questions including the correct dosage, schedules and timing of administration of the molecule, the main side effects and their treatment, and evaluation of the treatment response by CT scan.
  • Treatment with sunitinib started at a dose of 50 mg daily for 4 weeks followed by 2 weeks off (4/2).
  • After 6 cycles the treatment was stopped because of a rise in plasma NSE values and disease progression.
  • Response evaluation by CT scan should take into account tumor necrosis caused by sunitinib.
  • Sunitinib malate is an interesting molecule for targeted therapy also for advanced neuroendocrine tumors.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Indoles / therapeutic use. Paraganglioma / drug therapy. Paraganglioma / secondary. Pyrroles / therapeutic use. Retroperitoneal Neoplasms / pathology. Skull Neoplasms / drug therapy. Skull Neoplasms / secondary
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Chemotherapy, Adjuvant. Disease Progression. Drug Administration Schedule. Fatal Outcome. Humans. Male. Occipital Bone / pathology. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 21388069.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Indoles; 0 / Pyrroles; V99T50803M / sunitinib
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