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1. Suzuki K, Sai S, Kato K, Murase T: [A case of malignant lymphoma of the epididymis]. Hinyokika Kiyo; 2000 Apr;46(4):291-3
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  • [Title] [A case of malignant lymphoma of the epididymis].
  • The tumor originated from the epididymis and did not involve the testis or the spermatic cord.
  • Histologically, the tumor was diagnosed as a malignant lymphoma (non-Hodgkin's lymphoma, diffuse mixed cell type, B-cell type).
  • After establishment of the diagnosis of primary epididymal malignant lymphoma, 3 courses of chemotherapy (adriamycin, vincristine, cyclophosphamide, prednisolone) were performed.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols. Epididymis. Lymphoma, B-Cell / surgery. Lymphoma, Non-Hodgkin / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Humans. Male. Orchiectomy. Prednisolone / administration & dosage. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 10845166.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
  • [Number-of-references] 9
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2. Koizumi T, Nakanishi R, Taue R, Yamaguchi K, Nakatuji H, Kishimoto T, Izaki H, Oka N, Takahashi M, Fukumori T, Kanayama HO: [Case of tuberculous epididymitis caused by intravesical BCG therapy]. Hinyokika Kiyo; 2008 Sep;54(9):625-7

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  • [Title] [Case of tuberculous epididymitis caused by intravesical BCG therapy].
  • Intravesical Bacillus Calmette-Guerin (BCG) therapy is commonly used against superficial urothelial carcinoma, especially carcinoma in situ (CIS).
  • We report a case of tuberculous epididymitis that occurred during a course of intravesical BCG therapy.
  • A 76-year-old man had received intravesical BCG therapy for multiple superficial bladder cancer and CIS in prostatic urethra after transurethral resection of bladder tumor (TUR-Bt).
  • He recognized hard nodules in the left scrotum after 4 times intravesical BCG therapy.
  • Histological diagnosis was tuberculous epididymitis.
  • Postoperatively, he was administered chemotherapy consisting of isoniazid, refampin and ethambutol.
  • [MeSH-major] BCG Vaccine / administration & dosage. BCG Vaccine / adverse effects. Epididymis. Tuberculosis, Male Genital / etiology
  • [MeSH-minor] Administration, Intravesical. Aged. Antitubercular Agents / administration & dosage. Carcinoma in Situ / therapy. Cystectomy. Humans. Male. Orchiectomy. Urinary Bladder Neoplasms / therapy

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  • (PMID = 18975579.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / BCG Vaccine
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3. Mlika M, Chelly I, Benrhouma M, Haouet S, Horchani A, Zitouna MM, Kchir N: A Primary Testicular Diffuse Large B-cell Lymphoma Belonging to the Germinal Center B-cell-like Group. J Clin Med Res; 2010 Feb;2(1):47-9
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  • The authors report a new case of primary testicular lymphoma and highlight its diagnostic and therapeutic challenge.
  • Radiological findings consisted in multiple hypoechoic masses that corresponded in histological examination to a diffuse intratubular lymphomatous infiltration situated away from the spermatic cord, the epididymis, ductuli efferentes and rete testis.
  • The diagnosis of stage I primary testicular large B-cell lymphoma of germinal center B-cell-like group was made.
  • The patient is now treated by chemotherapy.
  • Primary testicular lymphoma is a rare tumour whose diagnosis is based on histological findings.
  • Treatment modalities consist in surgical excision, chemotherapy and radiation therapy but the accurate procedures are not standardized.
  • Factors that have been linked to more favorable outcomes include younger patient age, localized disease, presence of sclerosis at pathologic analysis, smaller tumour size, lower histological tumor grade and lack of epididymal or spermatic cord involvement.

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  • (PMID = 22457702.001).
  • [ISSN] 1918-3003
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3299176
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4. Segawa N, Abe H, Nishida T, Katsuoka Y: [Spermatic cord tuberculosis: a case report]. Hinyokika Kiyo; 2005 May;51(5):347-9
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  • A left spermatic cord tumor was suspected.
  • The mass did not connect with the testis or epididymis.
  • Antituberculous chemotherapy was subsequently initiated.
  • [MeSH-major] Spermatic Cord. Tuberculosis, Male Genital / diagnosis
  • [MeSH-minor] Aged. Antitubercular Agents / therapeutic use. Humans. Male. Orchiectomy

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  • (PMID = 15977604.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antitubercular Agents
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5. Mansi IA, Ashley I, Glezerov V: Retroperitoneal leiomyosarcoma and enlarged epididymis associated with a positive pregnancy test. Am J Med Sci; 2002 Aug;324(2):104-5
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  • [Title] Retroperitoneal leiomyosarcoma and enlarged epididymis associated with a positive pregnancy test.
  • Computerized tomography of the abdomen revealed a retroperitoneal mass measuring 30 x 21 x 13 cm.
  • Results of histopathology tests confirmed the diagnosis of leiomyosarcoma.
  • The level of serum beta-HCG decreased to < 0.2 mlU/mL after chemotherapy.
  • The incidence of increased levels of beta-HCG in sarcomas in general, and its potential role as a tumor marker, is not known.
  • [MeSH-major] Biomarkers, Tumor / secretion. Chorionic Gonadotropin, beta Subunit, Human / secretion. Epididymis / pathology. Leiomyosarcoma / diagnosis. Leiomyosarcoma / secretion. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / secretion

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  • (PMID = 12186103.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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6. Al-Quran SZ, Olivares A, Lin P, Stephens TW, Medeiros LJ, Abruzzo LV: Myeloid sarcoma of the urinary bladder and epididymis as a primary manifestation of acute myeloid leukemia with inv(16). Arch Pathol Lab Med; 2006 Jun;130(6):862-6
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  • [Title] Myeloid sarcoma of the urinary bladder and epididymis as a primary manifestation of acute myeloid leukemia with inv(16).
  • We describe a 47-year-old man with hematuria, who was subsequently found to have MS involving bladder and epididymis.
  • The neoplasm was composed predominantly of blasts that expressed CD68, CD117, myeloperoxidase, and lysozyme, with occasional immature eosinophils.
  • Although blood and bone marrow examinations showed no morphologic evidence of leukemia, conventional cytogenetic studies of marrow demonstrated inv(16)(p13q22) in 4 of 20 metaphases; fluorescence in situ hybridization of the bladder neoplasm also showed inv(16).
  • Following chemotherapy, the patient has been in complete remission for 32 months.
  • In our literature review, we identified 7 cases of MS involving bladder, only 3 without evidence of an associated myeloid neoplasm in marrow, none with cytogenetic data.
  • A high index of suspicion is required to establish the diagnosis of MS involving bladder.
  • Cytogenetic analysis is useful for both demonstrating minimal marrow disease and classifying MS in paraffin-embedded tissue sections.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Cytarabine / administration & dosage. Cytogenetic Analysis. Disease-Free Survival. Humans. Idarubicin / administration & dosage. In Situ Hybridization. Male. Middle Aged. Remission Induction

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  • (PMID = 16740041.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 04079A1RDZ / Cytarabine; ZRP63D75JW / Idarubicin
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7. Novella G, Porcaro AB, Righetti R, Cavalleri S, Beltrami P, Ficarra V, Brunelli M, Martignoni G, Malossini G, Tallarigo C: Primary lymphoma of the epididymis: case report and review of the literature. Urol Int; 2001;67(1):97-9
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  • [Title] Primary lymphoma of the epididymis: case report and review of the literature.
  • OBJECTIVE: To report an extremely rare clinical pathological observation of a case of primary lymphoma of the epididymis, without testicular or systemic involvement, and to update the relevant literature.
  • Clinical examination detected a hard painful mass at the right epididymal head.
  • Epididymitis was diagnosed and conservative therapy with antibiotics and anti-inflammatory drugs was given.
  • After 2 months of therapy the patient was admitted to our department because a tumor was suspected.
  • Tumor markers were normal.
  • The epididymal head was completely replaced by a hard white mass.
  • Fresh frozen sections indicated a malignant tumor.
  • RESULTS: High-grade primary epididymal non-Hodgkin's lymphoma with diffuse large cells (group G according to the Working Formulation) was diagnosed.
  • Clinical pathological staging detected stage IE (extranodal) primary epididymal lymphoma.
  • The patient was referred to the Hematologic Unit for combined chemotherapy, according to the VACOP-B protocol.
  • CONCLUSIONS: When an epididymal mass does not benefit from medical treatment, scrotal exploration and fresh frozen sections of the lesion should be done.
  • The possible bilateral involvement by primary epididymal lymphoma has to be kept in mind.
  • Radical orchiectomy is the treatment of choice for primary lymphoma of the epididymis.
  • Adjuvant chemotherapy is indicated in high-grade malignant lymphoma.
  • Prognostic parameters of the disease may be the grade of malignancy and the size of the tumor.
  • [MeSH-major] Epididymis. Lymphoma, Large B-Cell, Diffuse / pathology. Testicular Neoplasms / pathology

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  • [Copyright] Copyright 2001 S. Karger AG, Basel
  • (PMID = 11464129.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 5
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8. Lima GC, Varkarakis IM, Allaf ME, Fine SW, Kavoussi LR: Small cell carcinoma of epididymis: multimodal therapy. Urology; 2005 Aug;66(2):432
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  • [Title] Small cell carcinoma of epididymis: multimodal therapy.
  • Extrapulmonary small cell carcinoma is an infrequent tumor that can occur in various organs.
  • Although a few sporadic reports about extrapulmonary small cell carcinoma have been published, much remains to be uncovered about the clinical features, optimal treatment, and natural history.
  • We present a case of small cell carcinoma of the epididymis with retroperitoneal recurrence, an exceedingly rare tumor with behavior and treatment not well characterized.
  • Multimodal therapy with chemotherapy and retroperitoneal lymph node dissection was necessary to manage this aggressive disease.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Carcinoma, Small Cell / surgery. Epididymis. Genital Neoplasms, Male / drug therapy. Genital Neoplasms, Male / surgery. Retroperitoneal Neoplasms / secondary. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Combined Modality Therapy. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged

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  • (PMID = 16051319.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Arocena García Tapia J, Sanz Pérez G, Diez-Caballero Alonso F, Fernández FJ, Martín-Marquina Aspiunza A, Rodríguez-Rubio Cortadellas F, Rosell Costa D, Robles García JE, Zudaire Bergera JJ, Berián Polo JM: [Epididymal carcinoma. Bibliographic review in reference to a case]. Arch Esp Urol; 2000 Apr;53(3):273-5
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  • [Title] [Epididymal carcinoma. Bibliographic review in reference to a case].
  • [Transliterated title] Carcinoma de epidídimo. Revisión bibliográfica con motivo de un caso.
  • OBJECTIVE: To describe a case of epithelial cell paratesticular carcinoma of the epididymis and briefly review the literature on this tumor type.
  • A TUR biopsy of the bladder wall demonstrated undifferentiated carcinoma arising from the epididymis.
  • The patient did not respond to chemotherapy.
  • He developed systemic metastasis and died 4 months after the diagnosis.
  • CONCLUSIONS: Carcinoma of the epididymis is a rare malignant paratesticular tumor arising from the epithelial cells with a very poor prognosis.
  • Its clinical features are unspecific and this tumor type should be taken into account when making differential diagnosis from intrascrotal masses arsing from other causes.
  • Due to the rarity of this disease, it has not been possible to identify treatments that might achieve better results.
  • [MeSH-major] Epididymis. Testicular Neoplasms / pathology

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  • (PMID = 10851737.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] SPAIN
  • [Number-of-references] 9
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10. García-González J, Villanueva C, Fernández-Aceñero MJ, Paniagua P: Paratesticular desmoplastic small round cell tumor: case report. Urol Oncol; 2005 Mar-Apr;23(2):132-4
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  • [Title] Paratesticular desmoplastic small round cell tumor: case report.
  • BACKGROUND: The desmoplastic small round cell tumor has recently been separated from other small round cell tumors because of its characteristic pathological and clinical features.
  • Physical examination revealed a round elastic firm 2 to 3 cm mass distal to the tail of the epididymis, which was excised with a preoperative diagnosis of adenomatoid tumor.
  • However, histological and immunohistochemical diagnosis confirmed a desmoplastic small round cell tumor.
  • The extension study included a computed tomography scan and a plain chest radiograph, that showed no metastasis.
  • The patient received chemoradiation therapy with methotrexate, dacarbacin, cyclophosphamide, actinomycin D and vincristin, but had to be changed to a vincristin, actinomycin D, cyclophosphamide and adriamicin scheme on severe toxicity.
  • He completed five cycles of the chemotherapy with moderate toxicity.
  • Today, 6 years after diagnosis the patient remains well and free of disease.
  • CONCLUSIONS: Recent reviews on desmoplastic small round cell tumor affecting the paratesticular area have shown a better prognosis for tumors of this origin compared to abdominal ones.
  • We should include this lesion among the differential diagnosis of paratesticular tumors, mainly in children and adolescents.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Epididymis / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease-Free Survival. Humans. Male

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  • (PMID = 15869999.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Hagiuda J, Matsumoto M, Hanawa Y, Ishikawa H, Marumo K: [Adenocarcinoma of the rete testis. A case report]. Nihon Hinyokika Gakkai Zasshi; 2010 Nov;101(7):749-53
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  • Adenocarcinoma of the rete testis is a rare malignant tumor with a poor prognosis.
  • The diagnosis is often difficult and made incidentally.
  • Positron emission tomography (PET) was performed in another hospital, and the patient was referred for a left testicular tumor, multiple lung metastases, and para-aorta lymph node metastasis.
  • Pathological examination revealed a hard whitish mass around the testis involving the epididymis and tunica vaginalis and spreading under the subcutaneous tissue.
  • Histological examination revealed adenocarcinoma in the hilum of the testis, which extended to the subcutaneous tissue but not to the surface of the scrotum.
  • After the histological diagnosis of adenocarcinoma of the rete testis was confirmed, computed tomography (CT) was performed and showed multiple pulmonary nodules and para-aortica lymph node swelling of 3 cm diameter.
  • Because the patient did not wish to receive chemotherapy or other aggressive treatment, he has been followed-up with palliative care since his diagnosis.
  • Although local recurrence has occurred 4 months later, he is still alive for 8 months since his diagnosis.
  • [MeSH-major] Adenocarcinoma / therapy. Testicular Neoplasms / therapy
  • [MeSH-minor] Aged, 80 and over. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Orchiectomy. Palliative Care. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 21174741.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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12. Cao YQ, Ma SM, Fan XL, Lin YX, Chen MX, Song XA: [Epimedium alleviates chemotherapy-induced damage to the ultrastructure and function of rat epididymides]. Zhonghua Nan Ke Xue; 2008 Feb;14(2):184-8

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  • [Title] [Epimedium alleviates chemotherapy-induced damage to the ultrastructure and function of rat epididymides].
  • OBJECTIVE: To investigate the protective action of Epimedium against chemotherapy-induced damage to rat epididymides.
  • METHODS: Fifty 60-day-old male rats were divided into a control, a model and a treatment group.
  • In addition to procarbazine, Epimedium was given intragastrically to the treatment group.
  • The changes in the ultrastructure of the epididymis were observed after 10 and 20 days.
  • RESULTS: Electron microscopy showed that the chemotherapy-induced damages to the epididymal epithelia mainly included cell swelling, local cavitation of mitochondria, tumor-like change in nucleoli, agglutination of marginal translocation of heterochromatin and cell apoptosis.
  • The damage to the epithelial ultrastructure was slight in the treatment group as compared with the model rats.
  • Chemotherapy significantly affected sperm concentration, sperm viability and sialic acid (SA), which were (15.59 +/- 4.01) x 10(6)/ml, (76.71 +/- 10.11)% and (19.38 +/- 9.34) g/mg prot in the model group in comparison with (10.63 +/- 3.82) x 10(6)/ml (P < 0.01), (60.03 +/- 7.54)% (P < 0.01) and (13.62 +/- 7.81) g/g prot (P < 0.05) in the control.
  • Epimedium significantly increased sperm viability in the treatment group (60.03 +/- 7.54)% as compared with the model rats (69.90 +/- 12.58)% (P < 0.05).
  • CONCLUSION: Epimedium can lessen chemotherapy-induced damage to the epididymis and protect the reproductive function of rats.
  • [MeSH-major] Drugs, Chinese Herbal / pharmacology. Epididymis / drug effects. Epimedium / chemistry

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  • (PMID = 18390186.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drugs, Chinese Herbal
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13. Narayana K: Cisplatin induces duplex 3' overhangs and 5' blunt ends in epididymal epithelium in a Bax-dependent manner without any protection from L-ascorbic acid. Eur J Pharmacol; 2010 Sep 1;641(2-3):238-45
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  • [Title] Cisplatin induces duplex 3' overhangs and 5' blunt ends in epididymal epithelium in a Bax-dependent manner without any protection from L-ascorbic acid.
  • The ability of cisplatin (cis-diaminedichloroplatinum-II) to induce DNA double-strand breaks and expression of p53, Bax and Bcl-2 and possible protective effects of L-ascorbic acid was investigated in epididymis.
  • All animals were sacrificed within 72 h after the last treatment of cisplatin.
  • In conclusion, cisplatin induces structural changes, oxidative stress, irreparable DNA double-strand breaks bearing duplex 3' dT overhangs and 5' P-blunt ends in a Bax-dependent manner, but L-ascorbic acid has little, if any, preventive effects on cisplatin-induced epididymal damage.
  • [MeSH-major] Ascorbic Acid / pharmacology. Cisplatin / pharmacology. Epididymis / drug effects. bcl-2-Associated X Protein / pharmacology
  • [MeSH-minor] 3' Flanking Region. 5' Flanking Region. Animals. Biomarkers / metabolism. DNA Breaks, Double-Stranded / drug effects. Deoxyguanosine / analogs & derivatives. Deoxyguanosine / metabolism. Male. Mice. Mice, Inbred BALB C. Organ Size / drug effects. Oxidative Stress / drug effects. Random Allocation. Tumor Suppressor Protein p53 / metabolism

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  • [Copyright] Copyright (c) 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20566416.001).
  • [ISSN] 1879-0712
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; G9481N71RO / Deoxyguanosine; PQ6CK8PD0R / Ascorbic Acid; Q20Q21Q62J / Cisplatin
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14. Valdevenito Sepúlveda JP, Merhe Nieva E, Valdevenito Sepúlveda R, Cuevas Toro M, Gómez Gallo A, Bermúdez Luna H, Contreras Meléndez L, Gallegos Méndez I, Gallardo Escobar J, Palma Ceppi C: [Reduced retroperitoneal lymphadenectomy for clinical stage I non seminomatous germ cell testicular cancer]. Arch Esp Urol; 2007 Apr;60(3):245-54
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  • [Transliterated title] Linfadenectomia retroperitoneal reducida en cancer testicular de celulas germinales no seminomatoso estadio clinico I.
  • OBJECTIVES: The best treatment of clinical stage I non-seminomatous germ cell testicular cancer (NSGCTC) is controversial.
  • The objective of this study is to analyse our experience in the treatment of this patients with radical orchiectomy and reduced retroperitoneal lymphadenectomy (RRL) as the initial treatment.
  • INCLUSION CRITERIA: retroperitoneal staging with computed tomography (CT), normal tumor markers after orchiectomy and testicular and retroperitoneal biopsy informed at our hospital.
  • The following metastatic risk factors in the testicular biopsy were checked: vascular invasion (venous and/or lymphatic), infiltration of tunica albuginea, rete testis, epididymis, and spermatic cord.
  • Average surgery time 2 hr 7 min; average dissected lymph nodes 13.
  • Chemotherapy in 7 patients (19%) a total of 18 cycles.
  • Four cases of contralateral tumor during follow-up (11%).
  • Only epididymis infiltration was a significant predictor of metastasis (p=0,04).
  • Limited by the size of our study group, the epididymis infiltration was the only statistically significant predictor of metastasis.
  • [MeSH-minor] Adult. Humans. Male. Middle Aged. Neoplasm Staging. Retroperitoneal Space. Retrospective Studies

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  • (PMID = 17601299.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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15. Rais H, Elmansouri F, Belaabidia B, Essadki O, Oussehal A, Sarf I: [Paratesticular desmoplastic small round cell tumour: case report with literature review]. Cancer Radiother; 2010 Apr;14(2):111-4
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  • [Title] [Paratesticular desmoplastic small round cell tumour: case report with literature review].
  • [Transliterated title] La tumeur desmoplastique à petites cellules rondes paratesticulaire: à propos d'une observation avec revue de la littérature.
  • Physical examination revealed a round elastic firm 1-cm mass of the epididymis, which was excised.
  • A computed tomography scan showed a para-aortic mass of 1cm.
  • Histological and immunohistochemical diagnosis confirmed a desmoplastic small round cell tumor.
  • The patient received chemotherapy.
  • Today, 6 months after diagnosis the patient remains well and free of disease.
  • We should include this lesion among the differential diagnosis of paratesticular tumors, mainly in children and adolescents.
  • [MeSH-major] Epididymis / radiography. Testicular Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Cell Division. Child. Humans. Immunohistochemistry. Keratins / genetics. Male. Orchiectomy. Reverse Transcriptase Polymerase Chain Reaction. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright (c) 2009. Published by Elsevier SAS.
  • (PMID = 20189431.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 68238-35-7 / Keratins
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16. Santoro D, Savica V, Satta E, Scaffidi M, Mallamace A, Li Vecchi M, Bellinghieri G: Impotence in the 18th and 19th century: concepts of etiology and approaches to therapy. J Nephrol; 2009 Nov-Dec;22 Suppl 14:67-70
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  • [Title] Impotence in the 18th and 19th century: concepts of etiology and approaches to therapy.
  • Historically, the pharmacological treatments for impotence started in Greek times, when a myriad of herbal medications were applied locally to the genitals to enhance "sexual strength."
  • In the 18th century, theories about the main factors inducing impotence saw it as an abnormal state of the fibers, a defect in the solid or liquid substances or a bad structure (tumor, inflammation, abscess, ulcer or foreign body).
  • According to these mechanisms, when impotence depended on the state of the muscular fibers, treatment included a tepid bath and a clyster.
  • In the 19th century, therapies regarding impotence included slight electric stimulation through the application of stimulators on the scrotum in the testis or epididymis areas, until pain was induced.
  • [MeSH-major] Electric Stimulation Therapy / history. Erectile Dysfunction / history

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  • (PMID = 20013735.001).
  • [ISSN] 1121-8428
  • [Journal-full-title] Journal of nephrology
  • [ISO-abbreviation] J. Nephrol.
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article
  • [Publication-country] Italy
  • [Personal-name-as-subject] Graham J
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17. Song MY, Lv N, Kim EK, Kwon KS, Yoo YB, Kim JH, Lee SW, Song JH, Lee JH, Lee SK, Shin BC, Ryu DG, Park BH, Kwon KB: Antiobesity activity of aqueous extracts of Rhizoma Dioscoreae Tokoronis on high-fat diet-induced obesity in mice. J Med Food; 2009 Apr;12(2):304-9
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  • Mice that were fed a high-fat diet containing RDTE were found to have lower increases in body and epididymal adipose tissue weights and a lessened occurrence of hepatic steatosis than mice that were fed a high-fat diet.
  • The decreased adiposity that was induced by RDTE accounted for lower plasma levels of tumor necrosis factor-alpha, leptin, and glucose and a higher level of adiponectin.
  • RDTE was found to suppress the expression of SREBP-1 as well as that of fatty acid synthase in adipose and liver tissues in mice provided the high-fat diet.
  • [MeSH-major] Adipose Tissue / drug effects. Anti-Obesity Agents / therapeutic use. Dioscorea. Obesity / drug therapy. Phytotherapy. Plant Extracts / therapeutic use. Sterol Regulatory Element Binding Protein 1 / metabolism
  • [MeSH-minor] Adiponectin / blood. Animals. Blood Glucose. Body Weight / drug effects. Cholesterol / blood. Dietary Fats / administration & dosage. Epididymis / drug effects. Fatty Acid Synthases / genetics. Fatty Acid Synthases / metabolism. Fatty Liver / prevention & control. Gene Expression. Leptin / blood. Male. Mice. Mice, Inbred C57BL. Organ Size / drug effects. RNA, Messenger / metabolism. Rhizome. Triglycerides / blood. Tumor Necrosis Factor-alpha / blood

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  • (PMID = 19459730.001).
  • [ISSN] 1557-7600
  • [Journal-full-title] Journal of medicinal food
  • [ISO-abbreviation] J Med Food
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Anti-Obesity Agents; 0 / Blood Glucose; 0 / Dietary Fats; 0 / Leptin; 0 / Plant Extracts; 0 / RNA, Messenger; 0 / Sterol Regulatory Element Binding Protein 1; 0 / Triglycerides; 0 / Tumor Necrosis Factor-alpha; 97C5T2UQ7J / Cholesterol; EC 2.3.1.85 / Fatty Acid Synthases
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18. Hong XZ, Li LD, Wu LM: Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty liver disease. Clin Exp Pharmacol Physiol; 2007 Jan-Feb;34(1-2):27-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 1. Fenofibrate and xuezhikang are two types of drugs widely used in the treatment of dyslipidaemia in China.
  • Fenofibrate and xuezhikang treatment markedly improved NAFLD, ameliorating dyslipidaemia and fat accumulation in the liver, improving insulin resistance and ameliorating oxidative stress.
  • Hepatic steatosis, necro-inflammation and collagen deposition were lessened in the drug-treated groups.
  • 4. The common therapeutic mechanism of action of fenofibate and xuezhikang likely involves inhibition of the hepatic expression of tumour necrosis factor-alpha.
  • 5. The results suggest that fenofibrate and xuezhikang may have potential clinical application in the treatment of NAFLD.
  • [MeSH-major] Drugs, Chinese Herbal / pharmacology. Fatty Liver / drug therapy. Fenofibrate / pharmacology. Hypolipidemic Agents / pharmacology
  • [MeSH-minor] Alanine Transaminase / blood. Animals. Aspartate Aminotransferases / blood. Blood Glucose. Cholesterol / metabolism. Dietary Fats. Epididymis / pathology. Hepatomegaly / chemically induced. Insulin / blood. Liver / drug effects. Liver / metabolism. Liver / pathology. Male. Malondialdehyde / blood. Organ Size. PPAR alpha / genetics. RNA, Messenger / metabolism. Rats. Rats, Sprague-Dawley. Superoxide Dismutase / blood. Triglycerides / metabolism. Tumor Necrosis Factor-alpha / genetics

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  • (PMID = 17201732.001).
  • [ISSN] 0305-1870
  • [Journal-full-title] Clinical and experimental pharmacology & physiology
  • [ISO-abbreviation] Clin. Exp. Pharmacol. Physiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Dietary Fats; 0 / Drugs, Chinese Herbal; 0 / Hypolipidemic Agents; 0 / Insulin; 0 / PPAR alpha; 0 / RNA, Messenger; 0 / Triglycerides; 0 / Tumor Necrosis Factor-alpha; 0 / xuezhikang; 4Y8F71G49Q / Malondialdehyde; 97C5T2UQ7J / Cholesterol; EC 1.15.1.1 / Superoxide Dismutase; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase; U202363UOS / Fenofibrate
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19. Sengoz M, Abacioglu U, Salepci T, Eren F, Yumuk F, Turhal S: Extrapulmonary small cell carcinoma: multimodality treatment results. Tumori; 2003 May-Jun;89(3):274-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extrapulmonary small cell carcinoma: multimodality treatment results.
  • We report the results of a retrospective study of a multimodality treatment of 16 consecutive patients with a diagnosis of extrapulmonary small-cell carcinoma.
  • METHODS: Primary tumor site was prostate in 2, gallbladder in 2, uterine cervix in 2, liver in 2, endometrium in 1, epididymis in 1, colon in 1, larynx in 1, breast in 1, and unknown primary tumor in 3 patients.
  • All patients, except the one with a breast primary, were treated with chemotherapy (mostly platinum-based regimens).
  • CONCLUSIONS: Treatment results for extrapulmonary small-cell carcinoma are comparable to those of small-cell carcinomas of the lung.
  • [MeSH-major] Carcinoma, Small Cell / therapy. Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 12908782.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Montgomery E, Fisher C: Paratesticular liposarcoma: a clinicopathologic study. Am J Surg Pathol; 2003 Jan;27(1):40-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There were 30 paratesticular liposarcomas from men aged 41-87 years (mean 63 years; median 65 years) that involved the spermatic cord (23, 76%), testicular tunics (6, 20%), and epididymis (1, 4%).
  • One patient with WDL received radiation after his second recurrence and the myxoid/round cell liposarcoma received radiation and chemotherapy.
  • Only one example of DDL recurred, at 30 months; another patient, who refused therapy for 15 years, had a primary tumor 30 cm in diameter, displayed pulmonary metastases 1 month after excision, and died after 14 months.
  • One DDL recurred and only one of five (20%) developed metastases, but the mean follow-up for DDL was only 24 months.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Scrotum / pathology. Spermatic Cord / pathology. Testis / pathology

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  • (PMID = 12502926.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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