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Items 1 to 46 of about 46
1. Shim HJ, Hong YK, Kim SJ, Choi YJ, Kang JG: Carcinosarcoma on ascending colon found by bowel perforation: a case report. J Korean Soc Coloproctol; 2010 Oct;26(5):368-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinosarcoma on ascending colon found by bowel perforation: a case report.
  • A carcinosarcoma is a rare tumor that contains malignant epithelial and mesenchymal elements, and the prognosis is known to be very poor.
  • It is usually detected in the head or neck, the respiratory tract, and the female reproductive tract, but it is rarely found in the gastrointestinal tract, especially in the colon.
  • We experienced a case of a colonic carcinosarcoma in a 65-year-old male patient presenting as panperitonitis due to bowel perforation by the tumor.
  • Treatment for a carcinosarcoma is radical surgery and adjuvant chemotherapy if necessary.

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  • (PMID = 21152142.001).
  • [ISSN] 2093-7830
  • [Journal-full-title] Journal of the Korean Society of Coloproctology
  • [ISO-abbreviation] J Korean Soc Coloproctol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2998018
  • [Keywords] NOTNLM ; Carcinomatosis / Carcinosarcoma / Colon, ascending
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2. Hiraki M, Kitajima Y, Ohtsuka T, Kai K, Miyake S, Koga Y, Mori D, Noshiro H, Tokunaga O, Miyazaki K: Immunohistochemical and molecular genetic analyses of multiple sporadic gastrointestinal stromal tumors. World J Gastrointest Oncol; 2010 Sep 15;2(9):364-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A gastroduodenal endoscopic examination revealed no definitive localized lesions.
  • However, both a large amount of cruor and blood flow from the small intestine into the ascending colon was observed during the colonoscopic examination.
  • At least three tumors, believed to originate from the small intestine, were detected by abdominal computed tomography.
  • Based on these findings, multiple and hemorrhagic small intestinal tumors were diagnosed and surgical treatment of the tumors planned.
  • All excised specimens demonstrated morphology of a submucosal tumor and the largest tumor had a delle with coagulation on the mucosal face.
  • The immunohistochemical examination revealed that the tumor cells were diffusely positive for KIT and CD34.
  • The tumor sequencing results revealed an identical missense mutation in codon 642 of c-kit exon 13 leading to the replacement of lysine by glutamic acid and a silent germ-line mutation in exon 12 of the PDGFRA gene concerning whole blood, normal mucosa and tumors.
  • We concluded that the current subject was categorized as having multiple sporadic-type gastrointestinal stromal tumor with identical mutational types.
  • Although the patient did not receive any adjuvant chemotherapy, there has been no sign of recurrence over the 3 years since the surgery.

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  • (PMID = 21160808.001).
  • [ISSN] 1948-5204
  • [Journal-full-title] World journal of gastrointestinal oncology
  • [ISO-abbreviation] World J Gastrointest Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999140
  • [Keywords] NOTNLM ; Gastrointestinal stromal tumor / Germline mutation / K642E / KIT / Missense mutation / Platelet-derived growth factor receptor a / Surgery / c-kit
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3. Lu PH, Tao GQ, Shen W, Cai B, Jiang ZY, Sun J: Surgery for rare aneurysm associated with colorectal cancer. World J Gastroenterol; 2009 Dec 14;15(46):5879-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The occurrence of concomitant aortic aneurysm and colorectal cancer is a rare medical entity, and controversy surrounds its optimal treatment.
  • We report a case of rectal cancer and concomitant aneurysm from the ascending aorta to the common iliac artery.
  • As with DeBakey type I aortic dissecting aneurysm, our patient was treated by rectal cancer resection, with preservation of the anus (Dixon operation) under controlled hypotension.
  • The pathological examination of the surgical specimen showed a poorly differentiated T3N0 tumor.
  • The patient had an uneventful recovery without aneurysm rupture, and was discharged from hospital on postoperative day 15 after 3 d adjuvant chemotherapy with oxaliplatin combined with calcium folinate and fluorouracil.
  • The patient was given six courses of adjuvant chemotherapy in 6 mo, without recurrence or metastasis, and the aneurysm was still stable after 2 years follow-up.

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  • [Cites] Eur J Vasc Endovasc Surg. 2008 Nov;36(5):522-9 [18692416.001]
  • [Cites] Ann Thorac Surg. 2002 Jan;73(1):17-27; discussion 27-8 [11834007.001]
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  • [Cites] Tech Coloproctol. 2004 Nov;8 Suppl 1:s19-21 [15655618.001]
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  • [Cites] J Am Coll Surg. 2008 May;206(5):1065-73; discussion 1074-5 [18471757.001]
  • [Cites] J Surg Oncol. 2004 Dec 15;88(4):234-9 [15565595.001]
  • (PMID = 19998515.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2791287
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4. Ihtiyar E, Paşaoğlu O, Erkasap S, Karakaş BR, Yaşar FN: Perforated mixed carcinoid-adenocarcinoma in transverse colon and at gastroenterostomy site: case report. World J Surg Oncol; 2010;8:110
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perforated mixed carcinoid-adenocarcinoma in transverse colon and at gastroenterostomy site: case report.
  • Goblet cell carcinoid of the large intestine is a rare neoplasm, usually located in ascending colon and rectum.
  • A 60-year-old male patient underwent surgery after the diagnosis of acute abdomen.
  • Exploratory laparotomy revealed perforation with a diameter of 1 cm at the site of the previously performed gastroenterostomy and dilatation of the right colic flexure, secondary to a solid obstructive mass located in the mid-portion of transverse colon.
  • Histopathological investigation of the biopsies, taken from the gastroenterostomy site and the tumor, revealed mixed carcinoid-adenocarcinoma with carcinoid component, predominantly composed of goblet cells.
  • Our aim with this paper is to point out that more cases should be reported for more effective diagnosis, histopathological study, clinical investigation, treatment and prognosis of this specific neoplasm.
  • [MeSH-major] Carcinoid Tumor / pathology. Colonic Neoplasms / pathology. Gastroenterostomy. Intestinal Perforation / pathology
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colon, Transverse / pathology. Combined Modality Therapy. Fluorouracil / therapeutic use. Humans. Laparotomy. Leucovorin / therapeutic use. Male. Middle Aged. Organoplatinum Compounds / therapeutic use. Prognosis

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  • [Cites] Pathol Int. 2003 Jul;53(7):457-62 [12828611.001]
  • [Cites] Am J Surg Pathol. 1988 Aug;12(8):607-11 [3400791.001]
  • [Cites] Cancer. 1974 Aug;34(2):338-44 [4852178.001]
  • (PMID = 21176192.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Adenocarcinoid tumor; Folfox protocol
  • [Other-IDs] NLM/ PMC3014938
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5. Tsujie M, Fujiwara S, Kida H, Hayashi N, Fukuchi S, Yoshida T, Ebisui C, Sakita I, Hasuike Y, Fujimoto T: [A case of metastatic colon cancer treated with oxaliplatin combination chemotherapy]. Gan To Kagaku Ryoho; 2005 Oct;32(11):1774-5
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  • [Title] [A case of metastatic colon cancer treated with oxaliplatin combination chemotherapy].
  • A 77-year-old male had been operated for ascending colon cancer with liver metastases.
  • After hepatic artery injection therapy and CPT-11 plus 5'-DFUR combination therapy, oxaliplatin-based systemic chemotherapy was performed.
  • Consequently, the tumor size was controlled for about 10 months.
  • During the chemotherapy, we observed grade 3 neurological toxicity, but not grade 3-4 blood toxicity.
  • We conclude that the oxaliplatin-based chemotherapy may be useful for patients suffering 5-FU and CPT-11 resistant metastatic colorectal cancer in Japan.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Colonic Neoplasms / drug therapy. Organoplatinum Compounds / administration & dosage

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  • (PMID = 16315937.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Organoplatinum Compounds; 039LU44I5M / Floxuridine; 04ZR38536J / oxaliplatin; 7673326042 / irinotecan; V1JK16Y2JP / doxifluridine; XT3Z54Z28A / Camptothecin
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6. Inoue Y, Miki C, Ojima E, Kobayashi M, Hatada T, Kusunoki M: [A case of multiple liver metastases from colon cancer successfully treated with modified pharmacokinetic modulating chemotherapy using Leucovorin]. Gan To Kagaku Ryoho; 2002 Nov;29(11):2009-12
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  • [Title] [A case of multiple liver metastases from colon cancer successfully treated with modified pharmacokinetic modulating chemotherapy using Leucovorin].
  • A 51-year-old man underwent right hemicolectomy due to ascending colon cancer with multiple liver metastases.
  • Administration of modified pharmacokinetic modulating chemotherapy (PMC) using Leucovorin (intravenous infusion of 5-FU, 600 mg/m2/24 hours; oral administration of UFT, Taiho Pharmaceutical Co., Tokyo, Japan, 400 mg/day; and Isovorin, Wyeth Lederle Co., Tokyo Japan, 250 mg/body) was started postoperatively.
  • Two months of modified PMC produced a drastic tumor reduction without any adverse reactions such as diarrhea or myelosuppression observed.
  • At present the patient continues to tolerate the chemotherapy and is being followed as an outpatient clinic.
  • This case suggests the usefulness of modified PMC using Leucovorin for progressive recurrent colon cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Leucovorin / administration & dosage. Liver Neoplasms / secondary
  • [MeSH-minor] Administration, Oral. Colectomy. Combined Modality Therapy. Drug Administration Schedule. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Remission Induction. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 12465406.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; 1-UFT protocol
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7. Martenson JA Jr, Willett CG, Sargent DJ, Mailliard JA, Donohue JH, Gunderson LL, Thomas CR Jr, Fisher B, Benson AB 3rd, Myerson R, Goldberg RM: Phase III study of adjuvant chemotherapy and radiation therapy compared with chemotherapy alone in the surgical adjuvant treatment of colon cancer: results of intergroup protocol 0130. J Clin Oncol; 2004 Aug 15;22(16):3277-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase III study of adjuvant chemotherapy and radiation therapy compared with chemotherapy alone in the surgical adjuvant treatment of colon cancer: results of intergroup protocol 0130.
  • PURPOSE: Some patients with colon cancer have a high risk of local recurrence postoperatively.
  • This trial was undertaken to determine whether radiation therapy added to an adjuvant chemotherapy regimen improves outcome in high-risk patients.
  • PATIENTS AND METHODS: Patients with resected colon cancer with tumor adherence or invasion of surrounding structures, or with T3N1 or T3N2 tumors of the ascending or descending colon were randomly assigned to receive fluorouracil and levamisole therapy with or without radiation therapy.
  • Patients who received chemotherapy and radiation therapy (chemoRT) received 45 to 50.4 Gy in 25 to 28 fractions beginning 28 days after starting chemotherapy.
  • RESULTS: Overall 5-year survival was 62% for chemotherapy patients and 58% for chemoRT patients (P >.50); 5-year disease-free survival was 51% for both groups (P >.50).
  • Toxicity (>/= grade 3) occurred in 42% of chemotherapy patients and 54% of chemoRT patients (P =.04).
  • Leukopenia (>/= grade 3) occurred in 10% of chemotherapy patients and 22% of chemoRT patients (P =.02).
  • No significant difference in nonhematologic toxicity (>/= grade 3) was observed between chemoRT and chemotherapy patients (35% v 44%; P =.26).
  • CONCLUSION: Patients who received chemotherapy or chemoRT had similar overall survival and disease-free survival.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Colonic Neoplasms / radiotherapy. Neoplasm Recurrence, Local / prevention & control
  • [MeSH-minor] Administration, Oral. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Humans. Infusions, Intravenous. Levamisole / administration & dosage. Male. Middle Aged. Radiotherapy, Adjuvant. Risk Factors. Treatment Outcome

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  • [CommentIn] J Clin Oncol. 2004 Aug 15;22(16):3215-7 [15249588.001]
  • (PMID = 15249584.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 15083; United States / NCI NIH HHS / CA / CA 21115; United States / NCI NIH HHS / CA / CA 21661; United States / NCI NIH HHS / CA / CA 22433; United States / NCI NIH HHS / CA / CA 25224; United States / NCI NIH HHS / CA / CA 31946; United States / NCI NIH HHS / CA / CA 32102; United States / NCI NIH HHS / CA / CA 32115; United States / NCI NIH HHS / CA / CA 37404; United States / NCI NIH HHS / CA / CA 37422; United States / NCI NIH HHS / CA / CA 63849; United States / NCI NIH HHS / CA / CA 774400
  • [Publication-type] Clinical Trial; Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 2880D3468G / Levamisole; U3P01618RT / Fluorouracil
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8. Sugimoto K, Tashiro Y, Nagayasu K, Niwa K, Ono S, Ishiyama S, Hata M, Komiyama H, Takahashi M, Yaginuma Y, Kojima Y, Goto M, Tanaka M, Sengoku H, Okuzawa A, Tomiki Y, Sakamoto K: [A case of ascending colon cancer with unresectable distant metastases treated by systemic chemotherapy]. Gan To Kagaku Ryoho; 2010 Jun;37(6):1167-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of ascending colon cancer with unresectable distant metastases treated by systemic chemotherapy].
  • Detailed examinations revealed a circumferential ascending colon cancer, diffuse hepatic metastases scattered over both liver lobes, and lymph node metastases in the left axilla.
  • With the primary lesion-induced symptoms of stenosis controllable, the patient began systemic chemotherapy by mFOLFOX6 without a resection of the primary lesion.
  • After completing a 10-course treatment, the patient underwent surgery to resect the primary lesion in preparation for bevacizumab treatment.
  • In the postoperative systemic chemotherapy, FOLFIRI and mFOLFOX6 were administered concomitantly with bevacizumab.
  • He eventually died of cancer one year and seven months after diagnosis of the primary lesion or one year and one month subsequent to the resection of the primary lesion.
  • No consensus has been reached on the necessity to resect the primary lesion in patients with advanced colorectal cancer who also have unresectable distal metastases.
  • Systemic chemotherapy, nevertheless, can provide tumor control on both primary and metastatic lesions and could become a treatment option in the future.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Liver Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antibodies, Monoclonal, Humanized. Bevacizumab. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Camptothecin / therapeutic use. Colonoscopy. Combined Modality Therapy. Fatal Outcome. Fluorouracil / administration & dosage. Fluorouracil / therapeutic use. Humans. Leucovorin / administration & dosage. Leucovorin / therapeutic use. Lymphatic Metastasis. Male. Organoplatinum Compounds / administration & dosage. Organoplatinum Compounds / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 20567130.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 2S9ZZM9Q9V / Bevacizumab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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9. Miki Y, Ikenaga M, Miyamoto A, Tsujie M, Yasui M, Miyazaki M, Hirao M, Fujitani K, Mishima H, Nakamori S, Tsujinaka T: [Neoadjuvant chemotherapy and pancreatoduodenectomy for locally advanced colon cancer]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2220-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neoadjuvant chemotherapy and pancreatoduodenectomy for locally advanced colon cancer].
  • Type 1 tumor was found in the ascending colon on fiberscopic examination, and pathologic examination revealed moderate to highly differentiated adenocarcinoma.
  • Computed tomography of the abdomen demonstrated a main tumor and an adjacent large mass which was suspected to be lymph node metastasis.
  • The tumor invaded the superior mesenteric vein( SMV) and pancreas.
  • On the first laparotomy, a curative resection was difficult, and chemotherapy was planned.
  • [MeSH-major] Adenocarcinoma / therapy. Colonic Neoplasms / therapy. Neoadjuvant Therapy. Pancreaticoduodenectomy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Camptothecin / therapeutic use. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Male. Middle Aged. Organoplatinum Compounds / therapeutic use

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  • (PMID = 20037376.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
  • [Number-of-references] 3
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10. Saito H, Watanuki A, Tabira Y, Ikeda N, Urakawa M, Sakano T: [Huge ascending colon carcinoma, treated successfully with S-1 plus CPT-11, followed by significant tumor reduction and curative resection--a case report]. Gan To Kagaku Ryoho; 2009 Nov;36(11):1907-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Huge ascending colon carcinoma, treated successfully with S-1 plus CPT-11, followed by significant tumor reduction and curative resection--a case report].
  • Computed tomography (CT) and colonoscopy (CF)revealed a huge ascending colon tumor, invading the descending part of the duodenum.
  • Tumor reduction was significant on the preoperative CT and CF, with the invasion to the duodenum obscured.
  • Resected specimen revealed residual tumor in a small area of the submucosal to proper muscular layer of the contracted ascending colon, without pathological invasion to the duodenum.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colectomy. Colonic Neoplasms / therapy
  • [MeSH-minor] Aged. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Colonoscopy. Combined Modality Therapy. Drug Combinations. Female. Humans. Oxonic Acid / administration & dosage. Tegafur / administration & dosage. Tomography, X-Ray Computed

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  • (PMID = 19920399.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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11. Tamura T, Mizuyama Y, Shinto O, Nishihara T, Nakagawa H, Ono Y: [A long-term survival case of unresectable intrahepatic cholangiocarcinoma treated with chemotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2732-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A long-term survival case of unresectable intrahepatic cholangiocarcinoma treated with chemotherapy].
  • An 83-year-old man commuting to our hospital with postoperative ascending colon cancer was pointed out an increase of CA19-9.
  • Afterwards, the tumor had increased gradually.
  • Then, S-1 was changed to gemcitabine again because the enlargement of the tumor and the rise of tumor markers were observed.
  • Consequently, tumor markers decreased.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antimetabolites, Antineoplastic / therapeutic use. Bile Duct Neoplasms / drug therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / drug therapy. Deoxycytidine / analogs & derivatives. Oxonic Acid / therapeutic use. Tegafur / therapeutic use
  • [MeSH-minor] Aged, 80 and over. Drug Combinations. Humans. Male. Treatment Outcome

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  • (PMID = 21224695.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0W860991D6 / Deoxycytidine; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; B76N6SBZ8R / gemcitabine
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12. Seki H, Kurihara E, Iwata K, Saito J: [A case of local recurrence of colon cancer responding to chemotherapy with low-dose oxaliplatin, 5-FU and l-LV]. Gan To Kagaku Ryoho; 2007 Aug;34(8):1291-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of local recurrence of colon cancer responding to chemotherapy with low-dose oxaliplatin, 5-FU and l-LV].
  • A 68-year-old woman underwent right colectomy for cancer of the ascending colon, followed by a local recurrence 26 months after surgery.
  • She presented with fever and right lower abdominal pain, and was admitted to the hospital for locally recurrent colorectal cancer and tumor rupture.
  • Our case suggests that the mFOLFOX 4 regimen is effective for advanced or recurrent colorectal cancer with less toxicities including neuropathy,thus enabling patients to undergo long-term therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Colonic Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Aged. Carcinoembryonic Antigen / blood. Colectomy. Combined Modality Therapy. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Organoplatinum Compounds / administration & dosage

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  • (PMID = 17687216.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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13. Matsutani T, Sasajima K, Suzuki S, Matsushita A, Maruyama H, Matsuda A, Miyamoto M, Yokoyama T, Sugiura A, Yanagi K, Nishi Y, Arai H, Wakabayashi H, Tajiri T: [A case of ascending colon cancer with local recurrence responding completely to alternating modified-FOLFOX6 and FOLFIRI regimens(modified-FIREFOX regimen)]. Gan To Kagaku Ryoho; 2009 Mar;36(3):505-7
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  • [Title] [A case of ascending colon cancer with local recurrence responding completely to alternating modified-FOLFOX6 and FOLFIRI regimens(modified-FIREFOX regimen)].
  • A 58-year-old woman underwent right hemicolectomy with lymph node dissection(D2)for advanced ascending colon cancer which pathological examinations revealed to be moderately-differentiated adenocarcinoma.
  • She started adjuvant chemotherapy with oral administration of UFT-E(400 mg/day), but CEA and CA19-9 levels continued to elevate.
  • However, a recurrent tumor was not detected by computed tomography(CT)and endoscopic examinations.
  • After this therapy, repeated PET-CT showed that the abnormal FDG-uptake concentration had disappeared, leading to a complete response(CR).
  • She had maintained CR for the 12 months since undergoing chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy
  • [MeSH-minor] Biomarkers, Tumor / blood. Camptothecin / analogs & derivatives. Camptothecin / therapeutic use. Female. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Middle Aged. Organoplatinum Compounds / therapeutic use. Positron-Emission Tomography. Recurrence. Remission Induction. Tomography, X-Ray Computed

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  • (PMID = 19295282.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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14. Yamada K, Nishimura A, Matsuura O, Yamazaki S, Fujita M, Kubo N, Toyoki Y, Sasaki M: [A case of metastasis to the diaphragm from ascending colon cancer]. Gan To Kagaku Ryoho; 2008 Jan;35(1):145-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of metastasis to the diaphragm from ascending colon cancer].
  • We reported a case of metastatic tumor to the diaphragm discovered by rising CEA after operation of ascending colon cancer.
  • After discharge, she received adjuvant chemotherapy by S-1, but a rise of CEA was shown.
  • Based on exploratory findings, laparotomy was done with the diagnosis of metastasis to the liver(S7).
  • A tumor was present in the right diaphragm, and contacted the liver(S7).
  • The removed specimen revealed the same histological findings of the last operated ascending colon.
  • Etiologically speaking, the tumor cells might be absorbed or have strayed into peritoneal stomata of the diaphragm.
  • [MeSH-major] Colon, Ascending / pathology. Colonic Neoplasms / pathology. Diaphragm / pathology. Muscle Neoplasms / secondary
  • [MeSH-minor] Aged. Carcinoembryonic Antigen / blood. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 18195546.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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15. Sato H, Maeda K, Kuroda M, Maruta M: Poorly differentiated adenocarcinoma in the ascending colon with peritoneal dissemination: case report of a patient who survived more than eleven years. Acta Gastroenterol Belg; 2008 Jul-Sep;71(3):321-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Poorly differentiated adenocarcinoma in the ascending colon with peritoneal dissemination: case report of a patient who survived more than eleven years.
  • We report herein a case of a patient with a poorly differentiated adenocarcinoma in the ascending colon with peritoneal dissemination who survived more than eleven years thanks to adjuvant chemotherapy.
  • Barium enema study and colonoscopy showed an ascending colon tumor.
  • Abdominal computed tomography showed extensive ascites and masses besides the ascending colon and in the upper abdomen.
  • A continuous infusion of 3000 mg of 5-fluorouracil per 48 hours was given weekly for four weeks followed by 450 mg of oral UFT-E (Uracil:Tegafur) per day as post-operative chemotherapy.
  • Although she underwent removal of a breast cancer eight years after the operation for colon cancer, no sign of tumor progression has been observed for 132 months since the initial operation, by taking UFT-E without any adverse events.

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  • (PMID = 19198579.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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16. Fujie Y, Ikeda M, Seshimo I, Ezumi K, Hata T, Shingai T, Yasui M, Takayama O, Fukunaga H, Ikenaga M, Takemasa I, Yamamoto H, Ohue M, Sekimoto M, Hirota S, Monden M: Complete response of highly advanced colon cancer with multiple lymph node metastases to irinotecan combined with UFT: report of a case. Surg Today; 2006;36(12):1133-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete response of highly advanced colon cancer with multiple lymph node metastases to irinotecan combined with UFT: report of a case.
  • Massive lymph node metastasis of the para-aortic region and supraclavicular lymph nodes, Virchow's lymph node metastasis due to colon cancer, is extremely rare.
  • We herein report a case of such systemic lymph node metastasis that was successfully treated with a combination of irinotecan (CPT-11) and UFT, a combination drug of tegafur and uracil.
  • The patient was a 57-year-old woman who had a tumor in the ascending colon, and massively swollen para-aortic and supraclavicular lymph node metastasis.
  • She was treated with combination chemotherapy of CPT-11 and UFT.
  • The main tumor was detected as a decompressed scar, and the supraclavicular and para-aortic lymph nodes had completely disappeared after the second cycle of treatment.
  • A histopathological examination and immunohistochemistry with cytokeratin showed complete remission of adenocarcinoma in the tumor and para-aortic lymph nodes.
  • She remains alive without recurrence 52 months after chemotherapy.
  • Combination chemotherapy of CPT-11 and UFT may be of potential value in the treatment of advanced colorectal carcinoma, and both histopathological and immunohistochemical confirmation of a complete remission may indicate prolonged disease-free survival.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Colonic Neoplasms / drug therapy. Enzyme Inhibitors / therapeutic use
  • [MeSH-minor] Colonoscopy. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Middle Aged. Prodrugs. Tegafur / administration & dosage. Tegafur / therapeutic use. Tomography, X-Ray Computed. Uracil / administration & dosage. Uracil / therapeutic use

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  • [Cites] Arch Surg. 2000 May;135(5):530-4; discussion 534-5 [10807276.001]
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  • (PMID = 17123148.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Prodrugs; 0H43101T0J / irinotecan; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; XT3Z54Z28A / Camptothecin; 1-UFT protocol
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17. Sato H, Kuroda M, Maruta M, Maeda K, Koide Y: Mucoepidermoid carcinoma of the ascending colon: report of a case. Surg Today; 2002;32(11):1004-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid carcinoma of the ascending colon: report of a case.
  • An ulcerating tumor was thus identified in the ascending colon.
  • The tumor consisted of PAS-positive mucin-producing cells, epidermoid cells, and intermediate cells.
  • No differentiated squamous cell carcinoma cells were identified in any part of the tumor.
  • The tumor was diagnosed as a mucoepidermoid carcinoma of the ascending colon.
  • Unfortunately, despite chemotherapy, the patient developed liver metastases and died of liver failure 10 months postoperatively.
  • [MeSH-minor] Aged. Colectomy. Fatal Outcome. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 12444441.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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18. Koshiishi H, Yoshimura T, Okamura T, Tamamoto F, Takahashi E, Hayashi N, Koshiishi Y: [Evaluation of bronchial arterial infusion (BAI) for metastatic lung tumor from colorectal cancer]. Gan To Kagaku Ryoho; 2004 Oct;31(11):1838-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Evaluation of bronchial arterial infusion (BAI) for metastatic lung tumor from colorectal cancer].
  • Three cases of metastatic lung tumor from colorectal cancer with an ineffectual systemic chemotherapy were examined based on the therapeutic effectiveness and safety of bronchial infusion (BAI) as a symptomatic therapy.
  • Two out of three cases were rectal cancer and the third case being ascending colon cancer.
  • The lung metastases became large in size and thoracic symptoms (severe cough, chest pain) appeared in spite of the systemic chemotherapy of CPT-11, 5-FU and CDDP.
  • A low dosage of BAI was administered by using CPT-11 (40 mg/m2) + CDDP (40 mg/m2) as one shot, and was repeated (three and six times respectively) for the two cases.
  • BAI using low dosage of anti-cancer agents was effective, as means of improving the chest condition and quality of life in patients with metastatic lung tumor from colorectal cancer, with an ineffectual systemic chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Camptothecin / analogs & derivatives. Colorectal Neoplasms / pathology. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary


19. Kuwabara K, Ishida H, Ohsawa T, Nakata H, Murata N, Hashimoto D, Adachi A, Itoyama S: [Short-term intraperitoneal infusion of cisplatin and OK-432 for a case of malignant mesothelioma of the peritoneum]. Gan To Kagaku Ryoho; 2002 Nov;29(12):2333-5
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  • A case of malignant mesothelioma of the peritoneum successfully treated with short-term intraperitoneal chemotherapy is reported.
  • A 67-year-old woman underwent laparotomy for ascending colon cancer.
  • During, laparotomy, numerous mucoid nodules were found on the peritoneal surface, even though the colonic tumor did not invade the serosa.
  • The serum level of CA125 rapidly decreased after the chemotherapy, and was normalized 3 months postoperatively.
  • The histological diagnosis of the peritoneal lesions was malignant mesothelioma of the peritoneum (diffuse type).
  • These results suggest that this short-term chemotherapy is worth trying in cases of malignant mesothelioma of the peritoneum.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Cisplatin / administration & dosage. Infusions, Parenteral / methods. Mesothelioma / drug therapy. Peritoneal Neoplasms / drug therapy. Picibanil / administration & dosage
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans

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  • (PMID = 12484067.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 39325-01-4 / Picibanil; Q20Q21Q62J / Cisplatin
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20. Tomochika S, Hazama S, Nakatsu H, Yoshida S, Tokuhisa Y, Yoshino S, Oka M: [A case of ascending colon cancer successfully treated for synchronous liver metastases with mFOLFOX6 after a resection of the primary tumor]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2184-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of ascending colon cancer successfully treated for synchronous liver metastases with mFOLFOX6 after a resection of the primary tumor].
  • We report a case of ascending colon cancer successfully treated for synchronous liver metastases with mFOLFOX6 after a resection of the primary tumor.
  • A 79-year-old woman was diagnosed as having an ascending colon cancer with synchronous liver metastases.
  • A complete response was observed after the ninth course and the treatment finished at the twelfth course.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary
  • [MeSH-minor] Aged. Colectomy. Female. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Organoplatinum Compounds / therapeutic use

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  • (PMID = 20037364.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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21. Kunieda K, Saji S, Kuwabara I, Watanabe A, Katoh M, Sugiyama Y, Shimokawa K: Rapid growth of a retroperitoneal rhabdomyosarcoma following right hemicolectomy for ascending colon cancer: report of a case. Surg Today; 2000;30(4):372-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid growth of a retroperitoneal rhabdomyosarcoma following right hemicolectomy for ascending colon cancer: report of a case.
  • We report herein the case of a 69-year-old man in whom rapid growth of a retroperitoneal rhabdomyosarcoma occurred following hemicolectomy for ascending colon cancer.
  • On his first admission for surgery, a small lesion, 1.5 cm in diameter, was detected adjacent to the inner side of the left kidney by abdominal axial computed tomography (CT), which was initially suspected to be a benign lesion; however, a postoperative follow-up CT scan done 5 months later revealed that the lesion had enlarged remarkably to 8 cm in diameter.
  • Thus, total resection was performed under the presumed diagnosis of a malignant retroperitoneal tumor.
  • The tumor was found to be adjacent to the inner portion of the left kidney and covered by Gerota's fascia.
  • The resected specimen was 8.5 x 6.5 x 5 cm in size and was histologically confirmed as a retroperitoneal rhabdomyosarcoma of embryonal type.
  • Two courses of adjuvant chemotherapy with adriamycin, vincristine, and cyclophosphamide were given, and the patient has shown no signs of recurrence for 2 years since his second operation.
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 10795872.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
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22. Furumoto K, Kojima H, Takaya H, Okuno M, Fuji H, Mizuno R, Mori T, Ito D, Kogire M: [A case of advanced ascending colon cancer, curatively resected after complete response in left supraclavicular and paraaortic lymph nodes and liver metastases to FOLFOX4 therapy]. Gan To Kagaku Ryoho; 2010 Feb;37(2):323-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of advanced ascending colon cancer, curatively resected after complete response in left supraclavicular and paraaortic lymph nodes and liver metastases to FOLFOX4 therapy].
  • We report a resected case of ascending colon cancer with left supraclavicular and paraaortic lymph nodes and liver metastases which completely responded in terms of metastases but not the primary tumor to FOLFOX4 therapy.
  • Pathological examination of the supraclavicular lymph nodes showed undifferentiated adenocarcinoma, and ascending colon cancer was detected by colonoscopy which was a mixture of various types of differentiation.
  • FOLFOX4 therapy was effective for metastatic lesions but colon tumor did not regress and was accompanied by abdominal pain.
  • Macroscopically, a curative right hemicolectomy was performed, and microscopic examination revealed that the tumor had become a mass of undifferentiated cancer cells.
  • Thus, the present case demonstrates the dedifferentiation of colon cancer during chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Colonic Neoplasms / pathology. Liver Neoplasms / drug therapy
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Female. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Lymphatic Metastasis. Middle Aged. Organoplatinum Compounds / therapeutic use. Positron-Emission Tomography. Remission Induction. Tomography, X-Ray Computed

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  • (PMID = 20154495.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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23. Doi K, Ohchi T, Ogata K, Kikuchi N, Ishimoto T, Hashimoto D, Ochiai T, Muranaka T, Ogawa M: [Successful treatment of liver metastasis and extrahepatic metastasis with hepatic arterial infusion of CDDP, CPT-11, and 5-FU]. Gan To Kagaku Ryoho; 2004 Oct;31(11):1668-70
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  • [Title] [Successful treatment of liver metastasis and extrahepatic metastasis with hepatic arterial infusion of CDDP, CPT-11, and 5-FU].
  • A 63-year-old man, who had been operated with right hemicolectomy 1 year and 3 months ago, had giant liver metastasis, lung metastasis, and local dissemination tumor due to ascending colon cancer.
  • He was treated by systemic chemotherapy with 5-FU and the treatment evaluation was PD on CT.
  • After admission to our hospital, he was treated by hepatic arterial infusion chemotherapy with CDDP, CPT-11, and 5-FU.
  • After 3 courses of the treatment, each recurrent lesion decreased on CT and the CEA level decreased.
  • We believe hepatic arterial infusion chemotherapy with CDDP, CPT-11, and 5-FU may be an effective strategy against liver metastasis and extrahepatic metastsis due to colon cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary
  • [MeSH-minor] Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Cisplatin / administration & dosage. Colonic Neoplasms / pathology. Fluorouracil / administration & dosage. Hepatic Artery. Humans. Infusions, Intra-Arterial. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Middle Aged. Rectal Neoplasms / drug therapy. Rectal Neoplasms / secondary

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  • (PMID = 15553678.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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24. Kume S, Takahashi M, Kubota T, Hirata T, Torigoe Y, Ikeda O, Goto Y: [A case of colon cancer with multiple lung metastases responding completely to FOLFIRI and FOLFOX therapy]. Gan To Kagaku Ryoho; 2010 Sep;37(9):1809-12
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  • [Title] [A case of colon cancer with multiple lung metastases responding completely to FOLFIRI and FOLFOX therapy].
  • A 74-year-old man was administered FOLFIRI therapy, followed by modified FOLFOX therapy and FOLFIRI therapy due to ascending colon carcinoma with multiple lung metastases.
  • After 19 months, the tumor marker became normal, and CT and PET-CT revealed the multiple lung metastases had disappeared.
  • He was operated due to stenosis of the ascending colon carcinoma, and is now being treated with chemotherapy due to liver metastasis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Lung Neoplasms / drug therapy
  • [MeSH-minor] Aged. Camptothecin / analogs & derivatives. Camptothecin / therapeutic use. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Male. Organoplatinum Compounds / therapeutic use. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20841953.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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25. Ishizuka T, Yoshiyasu M, Yanagi K, Bando K, Yoshimura K, Tajiri T: [A patient with hepatic, pulmonary, and nodal metastases of colon cancer responding to CPT-11/TS-1 therapy]. Gan To Kagaku Ryoho; 2006 Jun;33(6):821-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A patient with hepatic, pulmonary, and nodal metastases of colon cancer responding to CPT-11/TS-1 therapy].
  • In December 2002, a 67-year-old man underwent right colectomy (stage IIIa, cur B) for cancer of the ascending colon.
  • Chemotherapy with 5'-DFUR and PSK was performed after surgery, but was discontinued due to grade 3 diarrhea.
  • The patient refused treatment with other drugs.
  • An increased CEA level was observed in July 2004, and metastasis of his colon cancer to the liver, lungs, and supraclavicular lymph nodes was confirmed.
  • The patient agreed to resume chemotherapy in December 2004, and received outpatient treatment with CPT-11 (70 mg/m(2) on days 1 and 8) and TS-1 (100 mg/day on days 1-14).
  • There was a significant decrease of tumor markers and a decrease in the size of the metastatic tumors, with these findings being judged as PR.
  • Diarrhea (grade 1) and oral ulceration (grade 2) were observed during treatment.
  • However, these side effects were transient and resolved temporarily without suspending therapy.
  • Although hepatic dysfunction (grade 2) was observed after the completion of cycle No.5, the patient decided to discontinue treatment.
  • CPT-11/TS-1 chemotherapy seems to be useful for maintaining the QOL of patients with metastatic colon cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Liver Neoplasms / drug therapy. Lung Neoplasms / drug therapy. Lymph Nodes / pathology
  • [MeSH-minor] Aged. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Colectomy. Combined Modality Therapy. Drug Administration Schedule. Drug Combinations. Humans. Lymphatic Metastasis. Male. Oxonic Acid / administration & dosage. Pyridines / administration & dosage. Quality of Life. Tegafur / administration & dosage

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  • (PMID = 16770105.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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26. mukai M, Moriya H, Himeno S, Oida Y, mukohyama S, Nishi T, Nakasaki H, Satoh S, Makuuchi H: Efficacy of oral UFT plus leucovorin therapy for colon cancer with ovarian and multiple liver metastases: report of two cases. Oncol Rep; 2001 Sep-Oct;8(5):1079-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of oral UFT plus leucovorin therapy for colon cancer with ovarian and multiple liver metastases: report of two cases.
  • Case 1: a patient was diagnosed as having ascending colon cancer with right ovarian metastasis, and underwent palliative right hemicolectomy plus oophorectomy.
  • The tumor was a well-differentiated adenocarcinoma with right ovarian metastasis, and the disease was classified as stage IV.
  • Oral chemotherapy with UFT plus LV was performed for about 3 years, and the patient is still being followed up with no recurrence at 5 years postoperatively.
  • Case 2: a patient was diagnosed as having incomplete large bowel obstruction caused by ascending colon cancer, and underwent curative right hemicolectomy.
  • The tumor was a moderately differentiated adenocarcinoma, and the disease was classified as stage II.
  • Since multiple liver metastases developed at 3 months postoperatively, oral chemotherapy with UFT plus LV was started.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Leucovorin / therapeutic use. Liver Neoplasms / drug therapy. Ovarian Neoplasms / drug therapy. Tegafur / therapeutic use. Uracil / therapeutic use
  • [MeSH-minor] Administration, Oral. Adult. Aged. Aged, 80 and over. Colectomy. Female. Humans. Neoplasm Staging. Ovariectomy. Postoperative Period. Remission Induction. Tomography, X-Ray Computed


27. Valdivia Gómez GG, Soto Guerrero MT, Cedillo de la Cruz MI: Extra-skeletal Ewing's sarcoma resembling acute abdomen. Case report. Cir Cir; 2010 Mar-Apr;78(2):159-62
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  • BACKGROUND: Extraosseous Ewing's sarcoma is a rare tumor of neuroectodermal origin.
  • It presents mainly in the soft tissue of the extremities and thorax.
  • CLINICAL CASE: We present the case of a male who arrived at the emergency room with acute abdomen, leucocytosis and imaging techniques (abdominal ultrasound and computed tomography) suggestive of complicated diverticular disease.
  • Intraoperative findings were an unsuspected tumor (20 x 15 x 15 cm).
  • Treatment consisted of extirpation of the tumor, separating it from the adjacent viscera and followed by chemotherapy based on epirubicin, cyclophosphamide and vincristine for six cycles.
  • Because the control abdominal CT demonstrated tumor activity in the retroperitoneum adjacent to the ascending colon and cecum, further resection was decided upon.
  • Due to the rarity of this tumor, only case reports or series have been found in the literature without randomized or comparative studies.
  • Surgery was the cornerstone of treatment, without reports of preoperative chemotherapy.
  • If the patient's condition permits, percutaneous needle biopsy is mandatory to obtain optimum treatment as well as to improve prognosis.
  • [MeSH-major] Abdomen, Acute / diagnosis. Retroperitoneal Neoplasms / diagnosis. Sarcoma, Ewing / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male

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  • (PMID = 20478118.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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28. Makino H, Kametaka H, Yasuno K, Koyama T, Seike K: [The effectiveness of reduction surgery and gemcitabine for multiple bowel obstructions due to peritoneal dissemination of pancreatic carcinoma with liver metastasis--a case report]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2416-8
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  • Computed tomography (CT) revealed pancreatic carcinoma invading to spleen with liver metastasis and peritoneal dissemination.
  • Due to peritoneal dissemination, severe stenosis and dilatation of the small intestine, stenosis of the ascending and sigmoid colon was admitted.
  • We performed a distal pancreatectomy, partial hepatectomy, partial resection of the stomach, five-partial resection of the small intestine, right colectomy and sigmoidectomy.
  • No operative complication was seen, and we started chemotherapy using gemcitabine soon after the operation.
  • After 3 months, the tumor markers normalized.
  • The removal of bowel obstruction by operation enabled us to perform intestinal nutrition and sufficient chemotherapy, which may lead to the favorable prognosis.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Intestinal Obstruction / therapy. Liver Neoplasms / secondary. Pancreatic Neoplasms / pathology. Peritoneal Neoplasms / complications. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Middle Aged

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  • (PMID = 20037441.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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29. Pramateftakis MG: Optimizing colonic cancer surgery: high ligation and complete mesocolic excision during right hemicolectomy. Tech Coloproctol; 2010 Nov;14 Suppl 1:S49-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present our experience with tumors of the proximal colon, for which a radical right hemicolectomy has been performed.
  • The tumor was located in the cecum in 37% of patients, the ascending colon in 58% of the patients and the hepatic flexure in 5% of the patients.
  • Out of all patients, 48 (42%) received adjuvant chemotherapy.
  • One patient developed a metachronous rectal carcinoma 28 months after his surgery, for which he underwent an abdoperineal resection.
  • It is important to remember that colon cancer treatment today is multimodal and that the improvement in patients' survival in the last decades is surely linked with the improvement in chemotherapy and the advances in the agents used.
  • However, optimal surgery is with no doubt an important element of good oncological outcome, as the experience with rectal cancer treatment has taught us.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colon / blood supply. Colon / surgery. Colonic Neoplasms / surgery. Female. Humans. Ligation. Male. Middle Aged. Survival Analysis

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  • [Cites] Acta Oncol. 2009;48(8):1152-6 [19863223.001]
  • [Cites] Am J Surg. 2007 Sep;194(3):349-54 [17693281.001]
  • [Cites] Colorectal Dis. 2009 May;11(4):354-64; discussion 364-5 [19016817.001]
  • [Cites] J R Soc Med. 1988 Sep;81(9):503-8 [3184105.001]
  • [Cites] Ann Surg. 2006 Oct;244(4):602-10 [16998369.001]
  • (PMID = 20697925.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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30. Sasaki Y, Natsuizaka M, Takano M, Suzuki M, Tsuyuguchi M, Nagasako T, Kawamura N, Kudo M, Tsuda I, Meguro J: [A case of primary adenocarcinoma of small intestine with multiple liver metastases successfully treated with mFOLFOX6]. Gan To Kagaku Ryoho; 2009 Nov;36(11):1927-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colonoscopy showed a tumor of Bauhin's valve and terminal ileum.
  • Biopsy of the tumor was performed and pathological examination revealed adenocarcinoma.
  • Histopathological examination revealed moderately-differentiated adenocarcinoma of Bauhin's valve and the terminal ileum, and no adenocarcinoma was found in the cecum and ascending colon.
  • Chemotherapy with mFOLFOX6 was performed after surgical resection.
  • After 5 courses of chemotherapy, abdominal CT showed marked regression of the liver metastases, and tumor marker (CA19-9) was normalized from 1,100 U/mL to 36 U/mL.
  • [MeSH-major] Adenocarcinoma / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ileal Neoplasms / pathology. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary

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  • (PMID = 19920403.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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31. Fujiwara S, Noguchi T, Suehiro S, Kikuchi R, Noguchi T, Uchida Y: [A case of multiple lung metastases of colon cancer with long-term survival following 5'-DFUR and cimetidine therapy]. Gan To Kagaku Ryoho; 2003 Aug;30(8):1177-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of multiple lung metastases of colon cancer with long-term survival following 5'-DFUR and cimetidine therapy].
  • Colonoscopic examination revealed a type 2 tumor in the ascending colon.
  • We diagnosed this case as ascending colon carcinoma with multiple lung metastases, and performed right hemicolectomy and D1 lymph node dissection.
  • Though no remarkable reduction of tumors was recognized, the increase of tumor size was relatively slow.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adjuvants, Immunologic / administration & dosage. Antimetabolites, Antineoplastic / administration & dosage. Cimetidine / administration & dosage. Colonic Neoplasms / drug therapy. Colonic Neoplasms / pathology. Floxuridine / administration & dosage. Histamine H2 Antagonists / administration & dosage. Lung Neoplasms / secondary
  • [MeSH-minor] Aged. Drug Therapy, Combination. Female. Humans

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  • (PMID = 12938277.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antimetabolites, Antineoplastic; 0 / Histamine H2 Antagonists; 039LU44I5M / Floxuridine; 80061L1WGD / Cimetidine; V1JK16Y2JP / doxifluridine
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32. Eisenkop SM, Spirtos NM, Friedman RL, Lin WC, Pisani AL, Perticucci S: Relative influences of tumor volume before surgery and the cytoreductive outcome on survival for patients with advanced ovarian cancer: a prospective study. Gynecol Oncol; 2003 Aug;90(2):390-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relative influences of tumor volume before surgery and the cytoreductive outcome on survival for patients with advanced ovarian cancer: a prospective study.
  • METHODS: Patients (408) with stage IIIC epithelial ovarian cancer had cytoreductive surgery before systemic platinum-based combination chemotherapy.
  • (1) right upper quadrant (diaphragm/hepatic, and adjacent peritoneal surfaces), (2) left upper quadrant (omentum/gastro-colic ligament, spleen, stomach, transverse colon, splenic flexure of colon), (3) pelvis (reproductive organs, recto-sigmoid, pelvic peritoneum), (4) retroperitoneum (pelvic/aortic nodes), and (5) central abdomen (small bowel, ascending/descending colon, mesentery, anterior abdominal wall, pericolic gutters).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Middle Aged. Neoplasm Staging. Prospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 12893206.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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33. Shoji H, Kuroki M, Hiramoto K, Matsumura Y, Miura A, Kikuchi Y, Hirakawa H: [A case of metastatic colorectal cancer suffering from hyperammonemic encephalopathy induced by 5-FU, continuously treated with FOLFOX therapy]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1583-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of metastatic colorectal cancer suffering from hyperammonemic encephalopathy induced by 5-FU, continuously treated with FOLFOX therapy].
  • We report a rare case of metastatic colorectal cancer who suffered from hyperammonemic encephalopathy induced by 5- FU and was continuously treated with FOLFOX therapy.
  • A 50-year-old man with ileus was diagnosed with ascending colon cancer Stage IV, and a right hemicolectomy was performed.
  • Postoperative chemotherapy with modified FOLFOX6 was performed.
  • Laboratory examination revealed hyperammonemia, so branched-chain amino acid solutions and high-volume drip infusion were started for its treatment.
  • We changed to chemotherapy for FOLFOX4 using branched-chain amino acid solutions and drip infusion.
  • The tumor marker level normalized following two courses, and CT following ten courses showed that the size of the lung metastasis and abdominal lymph node had reduced significantly.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Fluorouracil / adverse effects. Hyperammonemia / chemically induced. Lung Neoplasms / drug therapy
  • [MeSH-minor] Amino Acids, Branched-Chain / therapeutic use. Combined Modality Therapy. Humans. Leucovorin / adverse effects. Leucovorin / therapeutic use. Lymphatic Metastasis / radiography. Male. Middle Aged. Organoplatinum Compounds / adverse effects. Organoplatinum Compounds / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 20716892.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Amino Acids, Branched-Chain; 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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34. Liang JT, Lai HS, Lee PH: Laparoscopic medial-to-lateral approach for the curative resection of right-sided colon cancer. Ann Surg Oncol; 2007 Jun;14(6):1878-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic medial-to-lateral approach for the curative resection of right-sided colon cancer.
  • INTRODUCTION: Our previous randomized clinical trial comparing the laparoscopic medial-to-lateral dissection with the more classic lateral-to-medial approach for resection of rectosigmoid cancer showed that the medial approach reduces the operative time and the postoperative proinflammatory response.
  • Besides the oncologic advantages of an early vessel division and a "no-touch" dissection, we feel that the longer the lateral abdominal wall attachments of the colon are preserved, the better the exposure and the easier the dissection.
  • Encouraged by the above-mentioned positive findings, we therefore further conduct this phase II clinical trial to examine the feasibility and surgical outcomes regarding the utilization of this medial-to-lateral laparoscopic dissection approach for the curative resection of right-sided colon cancer.
  • METHODS: A total of 104 patients (from December 2000 to January, 2005) with advanced right-sided colon cancer (TNM stage II: n = 56; stage III: n = 48) requiring a curative right hemicolectomy were subjected to the laparoscopic medial-to-lateral approach that included initial exploration and ligation of ileocolic, right colic, and middle colic vessels in no-touch isolation fashion, subsequent medial-to-lateral extension of retroperitoneal dissection along Gerota fascia, opening of lesser sac by transection of gastrocolic ligament, and the final mobilization of hepatic flexure and lateral attachments of ascending colon (Fig. 1).
  • Postoperatively, adjuvant chemotherapy with Mayo Clinic Regimen was given in patients with stage III diseases.
  • RESULTS: The laparoscopic medial-to-lateral approach for a curative right hemicolectomy can be preformed with acceptable operation time (192.6 +/- 32.8 min, mean +/- standard deviation) and little blood loss (48.4 +/- 14.4 ml) through a small wound (6.0 +/- 0.8 cm).
  • During the follow-up periods (median: 30 months, range 6-55 months), recurrence of tumor developed in 6 (10.7%) of stage II and 10 (20.8%) of stage III patients, with liver metastasis in six patients, lung metastasis in 4, liver and lung metastasis in 1, intraperitoneal recurrence in 2, bone metastasis in 1, brain metastasis in 1, and port-site recurrence in 1.
  • [MeSH-major] Colectomy / methods. Colon, Ascending / surgery. Colonic Neoplasms / surgery. Laparoscopy / methods
  • [MeSH-minor] Blood Loss, Surgical. Chemotherapy, Adjuvant. Dissection / methods. Feasibility Studies. Follow-Up Studies. Hospitalization. Humans. Ileus / etiology. Ligaments / surgery. Ligation. Neoplasm Metastasis. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Pain, Postoperative / etiology. Postoperative Complications. Prospective Studies. Recovery of Function / physiology. Time Factors. Treatment Outcome

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  • (PMID = 17377832.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article
  • [Publication-country] United States
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35. Robertson JH, Dixit A, Smith A, Slevin M: An unusual tumor presentation. Int Surg; 2007 Jul-Aug;92(4):218-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual tumor presentation.
  • The key to diagnosis and management is tumor histology.
  • It also reinforces that germ cell tumor markers should be done in all young patients diagnosed with malignancy.
  • We describe the case of a 21-year-old man who was diagnosed as having inoperable cancer of the ascending colon, which turned out to be extragonadal germ cell tumor after studies.
  • This patient has responded very well to bleomycin, etoposide, and cisplatin chemotherapy.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonoscopy. Combined Modality Therapy. Diagnosis, Differential. Fluorodeoxyglucose F18. Humans. Male. Radiopharmaceuticals. Tomography, Emission-Computed. Tomography, X-Ray Computed

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  • (PMID = 18050831.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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36. Suzuki K, Nakazato T, Sanada Y, Mihara A, Tachikawa N, Kurai H, Yoshimura Y, Hayashi H, Yoshida S, Kakimoto T: [Successful treatment with hyper-CVAD and highly active anti-retroviral therapy (HAART) for AIDS-related Burkitt lymphoma]. Rinsho Ketsueki; 2010 Mar;51(3):207-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Successful treatment with hyper-CVAD and highly active anti-retroviral therapy (HAART) for AIDS-related Burkitt lymphoma].
  • Abdominal CT scan showed a large mass in the ascending colon.
  • Gallium scintigraphy demonstrated increased uptake in the ascending colon.
  • Colonoscopy was performed and histological examination of the colon tumor revealed Burkitt's lymphoma (BL).
  • He received highly active anti-retroviral therapy (HAART) and his facial palsy improved.
  • Although the tumor was decreased in size by DA-EPOCH, we changed to the combination of hyper-CVAD/MTX-Ara-C alternating therapy with HAART in order to increase dose intensity.
  • Our case suggests that intensive chemotherapy with hyper-CVAD/MTX-Ara-C combined with HAART may be well tolerated and effective in AIDS-related BL.
  • [MeSH-major] Antiretroviral Therapy, Highly Active. Burkitt Lymphoma / drug therapy. Colonic Neoplasms / drug therapy. Lymphoma, AIDS-Related / drug therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / administration & dosage. Cytarabine / administration & dosage. Dexamethasone / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Humans. Male. Methotrexate / administration & dosage. Prednisone / administration & dosage. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 20379116.001).
  • [ISSN] 0485-1439
  • [Journal-full-title] [Rinshō ketsueki] The Japanese journal of clinical hematology
  • [ISO-abbreviation] Rinsho Ketsueki
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate; CVAD protocol; EPOCH protocol
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37. Paulsen JE, Elgjo K: Effect of tumour size on the in vivo growth inhibition of human colon carcinoma cells (HT-29) by colon mitosis inhibitor. In Vivo; 2001 Sep-Oct;15(5):397-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of tumour size on the in vivo growth inhibition of human colon carcinoma cells (HT-29) by colon mitosis inhibitor.
  • We have previously shown that the colon mitosis inhibitor (CMI) suppresses the growth of transplanted HT-29 human colon carcinoma cells by approximately 40%.
  • However, this effect declined along the time-course, as the inoculums progressively grew larger.
  • In the present work we designed a test to assess the effectiveness of CMI as a function of tumour size.
  • After ranking the terminal tumours by ascending size in the control group and the CMI group the growth inhibition was calculated at each rank position.
  • The observed negative correlation between control tumour size and CMI inhibition (r = -0.94, p < 0.001) clearly demonstrated decreased growth inhibition with increased tumour size.
  • Furthermore, HT-29A4 displayed a similar tendency of decreased CMI effect with increased tumour size (r = -0.70, p < 0.001).
  • The apparent enhanced responsiveness among small tumours underlines the importance of early chemoprevention and chemotherapy.
  • [MeSH-major] Adenocarcinoma / pathology. Antineoplastic Agents / therapeutic use. Colonic Neoplasms / pathology. Growth Inhibitors / therapeutic use. Oligopeptides / therapeutic use
  • [MeSH-minor] Animals. Cell Division / drug effects. Clone Cells / drug effects. Clone Cells / transplantation. Disease Progression. Eflornithine / pharmacology. Eflornithine / therapeutic use. Humans. Mice. Mice, Inbred BALB C. Mice, Nude. Neoplasm Transplantation. Pyrrolidonecarboxylic Acid / analogs & derivatives. Tretinoin / pharmacology. Tretinoin / therapeutic use. Tumor Cells, Cultured / drug effects. Tumor Cells, Cultured / transplantation. Xenograft Model Antitumor Assays

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  • (PMID = 11695236.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Growth Inhibitors; 0 / Oligopeptides; 5688UTC01R / Tretinoin; 69275-10-1 / pyroglutamyl-histidyl-glycine; SZB83O1W42 / Pyrrolidonecarboxylic Acid; ZQN1G5V6SR / Eflornithine
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38. Itabashi M, Tada Y, Bamba Y, Takemoto K, Yoshimura Y, Kimura M, Hirosawa T, Ogawa S, Kameoka S: Case of peritoneal dissemination of colon cancer in which PET/CT was useful in determining the indicated surgical procedure. Int Surg; 2009 Jan-Feb;94(1):80-3
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  • [Title] Case of peritoneal dissemination of colon cancer in which PET/CT was useful in determining the indicated surgical procedure.
  • The right half of the colon was resected in a 70-year-old woman in August 2002 for ascending colon cancer.
  • Since tumor markers gradually increased, positron emission tomography (PET)/ computed tomography (CT) revealed peritoneal dissemination.
  • CT did not reveal well-defined tumor shadows.
  • Postoperative progress was favorable; the patient was discharged and enjoys a favorable quality of life through outpatient adjuvant chemotherapy.
  • PET/CT is suggested to be useful in observing the progress of peritoneal dissemination and may be of assistance in determining the course of treatment.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Tomography, Emission-Computed. Tomography, X-Ray Computed

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  • (PMID = 20099433.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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39. Miyake Y, Kato T, Katayama K, Doi T, Oshima K, Handa R, Hoshi M, Makari Y, Oshima S, Iijima S, Kurokawa E, Kikkawa N: [A case of ascending colon carcinoma metastasized to an inguinal hernia sac]. Gan To Kagaku Ryoho; 2007 Nov;34(12):2016-8

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  • [Title] [A case of ascending colon carcinoma metastasized to an inguinal hernia sac].
  • We report a case of ascending colon cancer metastasized to an inguinal hernia sac.
  • A 60-year-old man, who was undergone a right hemicolectomy for an ascending colon cancer, was pointed out a palpable inguinal mass at one year and eight months after the operation.
  • In the operation, a tumor of the inguinal hernia sac, which invaded to spermatic cord, could be found and was removed with right testis.
  • Bassini's method was performed after the resection of the inguinal tumor.
  • Histological examination revealed that the tumor was metastasis of colon carcinoma.
  • As for the advanced colon cancer, we need to mention the possibility of metastatic saccular tumor.
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Humans. Male. Middle Aged. Neoplasm Metastasis / drug therapy. Neoplasm Metastasis / pathology. Tomography, X-Ray Computed

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  • (PMID = 18219884.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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40. Wu J, Shao Y, Rong W, Wang X, Zhao D, Wang J, Bi J, Gao J, Zhang H, Liu Q, Zhang J: [Hand-assisted laparoscopic surgery in colorectal carcinoma resection: a report of 14 cases]. Zhonghua Zhong Liu Za Zhi; 2002 Nov;24(6):599-601
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  • RESULTS: Hand-assisted laparoscopic right hemicolectomy was performed in 6 of 8 ascending colon cancer patients, spending an average of 160 minutes (110 to 220 minutes) for the procedure.
  • All patients received postoperative chemotherapy.
  • All patients with rectal carcinoma received postoperative chemotherapy and radiotherapy.
  • CONCLUSION: Hand-assisted laparoscopic surgery in the treatment of colorectal carcinoma, a safe and simple procedure, not only ensures the clearance of tumor, but also reduces operative trauma and hastens recovery.
  • [MeSH-minor] Adult. Aged. Female. Hand. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 12667335.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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41. Holman E, Kovács G, Flaskó T, Maróti C, Vancsora J, Tóth C, Salah MA: Hand-assisted laparoscopic retroperitoneal lymph node dissection for nonseminomatous testicular cancer. J Laparoendosc Adv Surg Tech A; 2007 Feb;17(1):16-20
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  • MATERIALS AND METHODS: Between April 2002 and December 2004, 10 patients with testicular tumor were operated on, 6 on the right side and 4 on the left side.
  • Depending on the tumor site, a 6-7 cm mid-lower or -upper laparotomy was done, the HandPort (Smith and Nephew, Andover, MA) was placed in the abdominal wall, and the left hand of the surgeon was inserted into the abdomen.
  • The ascending or descending colon was mobilized completely.
  • RESULTS: The average operative time was 258 min (range, 150-432 min).
  • Patients with stage IIA or IIB disease on histopathology received 2-3 courses of combined chemotherapy.
  • A 6-7 cm muscle-splitting incision should be advantageous for patients compared to the xyphopubic laparotomy of the open procedure.

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  • [CommentIn] J Laparoendosc Adv Surg Tech A. 2009 Feb;19(1):85 [19196089.001]
  • (PMID = 17362172.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Popovich IG, Zabezhinski MA, Egormin PA, Tyndyk ML, Anikin IV, Spasov AA, Semenchenko AV, Yashin AI, Anisimov VN: Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen. Int J Biochem Cell Biol; 2005 May;37(5):1117-29
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  • [Title] Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen.
  • The effects of new antidiabetic drug Diabenol (9-beta-diethylaminoethyl-2,3-dihydroimidazo-(1,2-alpha)benzimidazol dihydrochloride) on life span and spontaneous tumor incidence in NMRI and transgenic HER-2/neu mice as well as on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats are studied.
  • It is shown that treatment with the drug failed influence body weight gain dynamics, food and water consumption and the body temperature, slowed down age-related disturbances in estrous function and increased life span of all and 10% most long-living NMRI mice.
  • The treatment with Diabenol inhibited spontaneous tumor incidence and increased the mammary tumor latency in these mice.
  • Diabenol treatment slowed down age-related changes in estrous function in HER-2/neu mice, failed influence survival of these mice and slightly inhibited the incidence and decreased the size of mammary adenocarcinoma metastases into the lung.
  • In rats exposed to 1,2-dimethylhydrazine, treatment with Diabenol significantly inhibited multiplicity of all colon tumors, decreased by 2.2 times the incidence of carcinomas in ascending colon and by 3.1 times their multiplicity.
  • Treatment with Diabenol was followed by higher incidence of exophytic and well-differentiated colon tumors as compared with the control rats exposed to the carcinogen alone (76.3% and 50%, and 47.4% and 14.7%, respectively).
  • Thus, the drug increases survival and inhibits spontaneous carcinogenesis in mice and inhibits colon carcinogenesis in rats.
  • [MeSH-major] Aging. Anticarcinogenic Agents / therapeutic use. Benzimidazoles / therapeutic use. Hypoglycemic Agents / therapeutic use
  • [MeSH-minor] 1,2-Dimethylhydrazine / pharmacology. Age Factors. Animals. Body Temperature. Body Weight. Colonic Neoplasms / drug therapy. Feeding Behavior. Female. Insulin / physiology. Mammary Neoplasms, Experimental / drug therapy. Mice. Mice, Inbred Strains. Mice, Transgenic. Neoplasms / drug therapy. Rats

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  • (PMID = 15743682.001).
  • [ISSN] 1357-2725
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 9-diethylaminoethyl-2,3-dihydroimidazo(1,2alpha)benzimidazole; 0 / Anticarcinogenic Agents; 0 / Benzimidazoles; 0 / Hypoglycemic Agents; 0 / Insulin; IX068S9745 / 1,2-Dimethylhydrazine
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43. Ogata Y, Tsuda H, Matono K, Kumabe T, Saitsu H, Hara H, Akagi Y, Araki Y, Sata M, Shirouzu K: Long-term survival following treatment with antineoplastons for colon cancer with unresectable multiple liver metastases: report of a case. Surg Today; 2003;33(6):448-53
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  • [Title] Long-term survival following treatment with antineoplastons for colon cancer with unresectable multiple liver metastases: report of a case.
  • We report a case of survival for nearly 8 years after treatment of unresectable multiple liver metastases from colon cancer, using microwave ablation and the nontoxic antitumor agent, the antineoplastons.
  • A 72-year-old man diagnosed with adenocarcinoma of the ascending colon and 14 bilateral liver metastases underwent a right hemicolectomy combined with microwave ablation of six metastatic liver tumors.
  • We also decided to give antineoplastons to inhibit metastatic tumor growth and recurrence.
  • Computed tomography scans done 1 and 4 years after the initial diagnosis showed recurrent tumors in S(4) and S(7), respectively.
  • This case report demonstrates the potential effectiveness of the nontoxic antitumor agent, the antineoplastons, for controlling liver metastases from colon cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Benzeneacetamides. Colonic Neoplasms / drug therapy. Liver Neoplasms / secondary. Piperidones / therapeutic use
  • [MeSH-minor] Aged. Colectomy. Combined Modality Therapy. Electrocoagulation / methods. Humans. Male. Microwaves / therapeutic use. Prognosis. Survivors

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  • (PMID = 12768372.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzeneacetamides; 0 / Piperidones; 91531-30-5 / antineoplaston A10
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44. Tsuji Y, Hamada H, Yasuda D, Okamura M, Watanabe K, Takahashi T, Takada J, Katsuki Y: [Resection made possible following hepatic arterial infusion in 2 cases of hepatic metastases from colorectal cancer]. Gan To Kagaku Ryoho; 2002 Nov;29(12):2100-3
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  • Arterial infusion was performed 21 times, with the total volume of 5-FU administered being 31.5 g.
  • Case 2: An 82-year-old female, with cancer of the ascending colon, sigmoidal colon and multiple hepatic metastases (H3, metachronous).
  • Arterial infusion was performed 16 times, with the total amount of 5-FU administered being 20 g.
  • A lowering of CEA levels and reduction of tumor size were achieved, and hepatic resection was performed.
  • Even among cases of unresectable hepatic metastases from colorectal cancer, there are some in which resection is possible following hepatic arterial infusion chemotherapy, with the possibility of complete cure.
  • [MeSH-major] Colorectal Neoplasms / pathology. Hepatectomy. Infusions, Intra-Arterial. Liver Neoplasms / secondary. Liver Neoplasms / therapy

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  • (PMID = 12484012.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; U3P01618RT / Fluorouracil
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45. Katsumoto Y, Aritake N, Endoh A: [The efficacy of cetuximab for metastatic colorectal cancer]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2523-5
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  • Cetuximab (Erbitux) is a targeted therapy that used to treat metastatic colorectal cancer.
  • We report 6 patients who responded well to cetuximab out of 8 patients with recurrent/advanced colorectal cancer who have received the drug at our hospital since November 2008.
  • The primary cancers were located in the rectum (n=1), sigmoid colon (n=4), and ascending colon (n=1).
  • These patients were treated with cetuximab as second-line (n=1), third-line (n=3), fifth-line (n=1), or seventh-line (n=1) therapy.
  • Three patients received cetuximab monotherapy, while the other 3 were given CPT-11 (150 mg/m2, every 2 weeks) as concomitant therapy.
  • Among the 3 patients receiving combination therapy, 2 patients had already received treatment with FOLFIRI.
  • Tumor markers also showed large decreases, with the percent decrease at 1 month being 31.7% and 60.8% in the monotherapy and combination therapy groups, respectively, while it was respectively 14.1% and 29.5% at 2 months.
  • The mean progression-free survival (PFS) time and the time to treatment failure (TTF) were respectively 3.0 months and 4.5 months in the monotherapy group versus 7.3 months and 9.3 months in the combination therapy group.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Colorectal Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antibodies, Monoclonal, Humanized. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Camptothecin / therapeutic use. Cetuximab. Female. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Male. Middle Aged. Rectal Neoplasms / drug therapy. Sigmoid Neoplasms / drug therapy

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  • (PMID = 21224627.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 7673326042 / irinotecan; PQX0D8J21J / Cetuximab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; IFL protocol
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46. Wright CL, Stewart ID: Histopathology and mismatch repair status of 458 consecutive colorectal carcinomas. Am J Surg Pathol; 2003 Nov;27(11):1393-406
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  • Patients with these tumors have an improved prognosis and may show greater sensitivity to chemotherapy.
  • MMR-d tumors presented at an earlier stage than intact tumors, and the node-positive MMR-d tumors were less likely than intact tumors to have pericolonic extranodal tumor deposits (18.2% vs. 44%).
  • The proportion of tumors at each site that were MMR-d increased progressively from cecum (32%) to ascending (35%) to transverse colon, where 41% of all tumors were defective.
  • Both types of MMR-d tumors more often had expansive borders, intraepithelial lymphocytosis, peritumoral lymphoid, and Crohn's-like lymphoid responses than the intact tumors; the frequencies of these features diminished with advancing stage.
  • Tumor budding was less common in stage II and III MMR-d tumors than in intact tumors.
  • Keloid and myxoid type stromas correlated with stage and vascular invasion and were not related to mismatch repair status.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adult. Aged. Aged, 80 and over. Carrier Proteins. Colon, Ascending / chemistry. Colon, Ascending / pathology. Colon, Descending / chemistry. Colon, Descending / pathology. DNA, Neoplasm / analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. MutS Homolog 2 Protein. Neoplasm Proteins / analysis. Neoplasm Proteins / genetics. Neoplasm Staging. Neoplasms, Second Primary. Nuclear Proteins. Proto-Oncogene Proteins / analysis. Proto-Oncogene Proteins / genetics

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  • (PMID = 14576472.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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