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1. Shimizu J, Ishida Y, Hirano Y, Tatsuzawa Y, Kawaura Y, Nozawa A, Yamada K, Oda M: Cardiac herniation following intrapericardial pneumonectomy with partial pericardiectomy for advanced lung cancer. Ann Thorac Cardiovasc Surg; 2003 Feb;9(1):68-72
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  • We present in this paper a case of cardiac herniation following right intrapericardial pneumonectomy after induction chemotherapy.
  • A 52-year-old man with advanced squamous cell carcinoma of the lung was admitted to our hospital suffering from a dry cough and chest pain.
  • Just prior to removal of the tracheal tube, cardiac herniation occurred with hypotension, arrhythmia and cardiac arrest.
  • Unless prompt diagnosis and surgical treatment can be accomplished, cardiac herniation can be a fatal complication.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Heart Diseases / etiology. Lung Neoplasms / surgery. Pericardium / surgery. Pneumonectomy / methods

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  • (PMID = 12667133.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Tanaka A, Ohsawa H, Ikeda H, Koshiba R: [Therapeutic strategy for a patient suffering from a peripheral pulmonary tumor in the right upper lobe and an endotracheal tumor in the carina]. Kyobu Geka; 2002 Jul;55(7):537-40
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  • [Title] [Therapeutic strategy for a patient suffering from a peripheral pulmonary tumor in the right upper lobe and an endotracheal tumor in the carina].
  • A 64-year-old male, who had received successful radiotherapy for the previous laryngeal cancer, was admitted to our department for the treatment of a peripheral pulmonary tumor in the right upper lobe and an endotracheal tumor in the carina.
  • The endotracheal biopsy of the carinal tumor demonstrated squamous cell carcinoma, though preoperative examination of the intrapulmonary tumor was unable to clarify it's pathological type.
  • Since the endotracheal cancer was diagnosed as an intra mucosal tumor by the preoperative computed tomography (CT) scans and the bronchoscopic examination, laser abrasion therapy to the endotracheal tumor was performed 4 days before the lobectomy of the intrapulmonary tumor.
  • After the pulmonary operation, the intrapulmonary tumor was diagnosed as squamous cell carcinoma without lymph node metastasis, and it was suggested to be a metastatic tumor of the previous laryngeal cancer.
  • Both radiotherapy to the carina and general chemotherapy with docetaxel hydrate and carboplatin were used as adjuvant therapies 36 days after the lobectomy.
  • Laser abrasion therapy to the endotracheal tumor is very useful and safe for the patient, who should then receive pulmonary resection soon after the therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Paclitaxel / analogs & derivatives. Pneumonectomy. Taxoids. Tracheal Neoplasms / surgery
  • [MeSH-minor] Carboplatin / administration & dosage. Combined Modality Therapy. Humans. Laser Therapy. Lymph Node Excision. Male. Middle Aged

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  • (PMID = 12136580.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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3. Hakimelahi GH, Ly TW, Yu SF, Zakerinia M, Khalafi-Nezhad A, Soltani MN, Gorgani MN, Chadegani AR, Moosavi-Movahedi AA: Design and synthesis of a cephalosporin-retinoic acid prodrug activated by a monoclonal antibody-beta-lactamase conjugate. Bioorg Med Chem; 2001 Aug;9(8):2139-47
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  • These four heretofore undescribed compounds 6, 7, 11, and 12 showed inhibitory activity against murine leukemias (L1210 and P388), sarcoma 180, breast carcinoma (MCF7), and human T-lymphocytes (Molt4/C8 and CEM/0).
  • They also inhibited squamous metaplasia and keratinization in tracheal organ cultures derived from vitamin-A-deficient hamsters.
  • These notions provide a new approach to the use of beta-retinoic acid for antitumor therapy.
  • [MeSH-minor] Animals. Antibodies, Monoclonal / metabolism. Antineoplastic Agents / chemical synthesis. Antineoplastic Agents / chemistry. Antineoplastic Agents / toxicity. Cell Survival / drug effects. Cephalosporins / chemistry. Drug Design. Drug Stability. Humans. Hydrolysis. Keratins / drug effects. Keratins / metabolism. Kinetics. Magnetic Resonance Spectroscopy. Metaplasia / prevention & control. Mice. Rats. Solubility. Tretinoin / chemistry. Tretinoin / toxicity. Tritium. Tumor Cells, Cultured. Water / chemistry

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  • (PMID = 11504650.001).
  • [ISSN] 0968-0896
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / Cephalosporins; 0 / Esters; 0 / Prodrugs; 059QF0KO0R / Water; 10028-17-8 / Tritium; 5688UTC01R / Tretinoin; 68238-35-7 / Keratins; EC 3.5.2.6 / beta-Lactamases
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4. Kosaba S, Yamamoto K: [Carinal reconstruction with wide airway resection by a new technique]. Kyobu Geka; 2001 Jan;54(1):4-7
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  • A 61-year man with tracheal stenosis by tracheal cancer, 6 tracheal rings, 2 left bronchial rings, total right main bronchus, for which carina was resected and reconstructed by a new technique and for a 69 year man with lung cancer in right upper lobe, for which right upper-middle bilobectomy, S6 segmental resection and circumferential pulmonary artery resection were performed.
  • The tracea, left main bronchus, and right basal segment bronchus were anastomosed by new technique and the right main pulmonary artery and basal segment artery was anastomosed subsequent to chemotherapy.
  • The new reconstructive method of carina permits simple anastomosis, the possibility of carina reconstruction even in the case of wide airway resection and loss tension at the site of anastomosis.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neoplasms, Multiple Primary / surgery. Reconstructive Surgical Procedures / methods. Trachea / surgery. Tracheal Neoplasms / surgery
  • [MeSH-minor] Aged. Anastomosis, Surgical / methods. Humans. Lung Neoplasms / surgery. Male. Middle Aged. Neoplasm Invasiveness. Pneumonectomy. Treatment Outcome

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  • (PMID = 11197908.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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5. Takamura H, Sasaki S, Hasebe K, Urade M, Yagi M: [A trial of continuous and biweekly low-dose cisplatin and 5-FU with UFT chemotherapy for esophageal cancer]. Gan To Kagaku Ryoho; 2002 Oct;29(10):1809-15
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  • [Title] [A trial of continuous and biweekly low-dose cisplatin and 5-FU with UFT chemotherapy for esophageal cancer].
  • A 77-year-old man with advanced esophageal cancer with tracheal and esophageal obstruction underwent continuous low-dose FP chemotherapy for a total of seven weeks, resulting in a complete response (CR) and disappearance of the esophago-tracheal fistula.
  • Since discharge from the hospital, he has maintained a stable good condition for about two years while receiving biweekly low dose FP chemotherapy and oral UFT.
  • Eight patients who had post-operative recurrence and underwent noncurative operation for esophageal cancer were given low-dose FP chemotherapy.
  • The results of this chemotherapy for those 8 patients and the present patient, for a total of 9 patients were 2 CR, 2 PR, 3 NC and 2 PD, with an overall response rate of 44%, and overall one-year and two-year survival rates of 44% and 22%, respectively.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Esophageal Neoplasms / drug therapy
  • [MeSH-minor] Aged. Cisplatin / administration & dosage. Dose-Response Relationship, Drug. Drug Administration Schedule. Drug Combinations. Female. Fluorouracil / administration & dosage. Humans. Infusions, Intra-Arterial. Male. Middle Aged. Survival Rate. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 12402435.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / UFT(R) drug; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; CF regimen
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6. Le Péchoux C, Baldeyrou P, Ferreira I, Mahé M: [Thoracic adenoid cystic carcinomas]. Cancer Radiother; 2005 Nov;9(6-7):358-61
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  • Adenoid cystic carcinomas in the trachea are rare, but represent around 40% of all tracheal tumours.
  • Adenoid cystic carcinoma's growth rate is slow so that it is frequently diagnosed at an advanced stage.
  • Treatment in limited tumours is based upon surgical resection often combined to radiotherapy because of close surgical margins.
  • Radiotherapy dose may vary between 45 and 65 Gy according to margins status.
  • Among inoperable patients treated with exclusive radiotherapy for tracheal tumours (including adenoid cystic but also squamous cell carcinomas of poorer prognosis), the recommended delivered dose should be over 60 Gy.
  • They are considered chemo-resistant and targeted therapies may prove to be effective in the future.
  • [MeSH-major] Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / surgery. Tracheal Neoplasms / radiotherapy. Tracheal Neoplasms / surgery
  • [MeSH-minor] Combined Modality Therapy. Drug Resistance, Neoplasm. Humans. Neoplasm Metastasis. Prognosis. Radiotherapy, Adjuvant. Survival

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  • (PMID = 16168695.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 19
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7. Krauss N, Wein A, Boxberger F, Baum U, Männlein G, Sezer O, Hahn EG, Benninger J: Complete remission with long-term survival in a patient with esophageal carcinoma and a tracheoesophageal fistula after treatment with the AIO regimen and bi-weekly cisplatin. Z Gastroenterol; 2004 Aug;42(8):739-42
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  • [Title] Complete remission with long-term survival in a patient with esophageal carcinoma and a tracheoesophageal fistula after treatment with the AIO regimen and bi-weekly cisplatin.
  • INTRODUCTION: To date, only few reports are available on patients with esophageal carcinoma containing a tracheoesophageal fistula under chemotherapy.
  • CASE REPORT: A 56-year-old patient presented to the hospital with a stenosing squamous cell carcinoma of the esophagus containing a tracheoesophageal fistula 3 cm above the carina.
  • A tracheal Y-Dumont metallic stent was inserted prior to initiating systemic treatment.
  • After three cycles of chemotherapy (six months) the patient revealed complete remission (CR) with closure of the tracheoesophageal fistula.
  • The tracheal Y-Dumont stent could be removed and the patient had oral alimentation restored.
  • 29 months after initiating treatment he is without evidence of disease.
  • CONCLUSION: Patients with esophageal carcinoma containing a tracheoesophageal fistula might benefit from chemotherapy and should not be generally excluded from systemic treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cisplatin / administration & dosage. Esophageal Neoplasms / complications. Esophageal Neoplasms / drug therapy. Tracheoesophageal Fistula / drug therapy. Tracheoesophageal Fistula / etiology
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Disease-Free Survival. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Male. Middle Aged. Remission Induction / methods. Survivors. Treatment Outcome

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  • (PMID = 15314727.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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8. Jereczek-Fossa BA, Jassem J, Orecchia R: Cervical lymph node metastases of squamous cell carcinoma from an unknown primary. Cancer Treat Rev; 2004 Apr;30(2):153-64
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  • [Title] Cervical lymph node metastases of squamous cell carcinoma from an unknown primary.
  • Cervical lymph node metastases of squamous cell carcinoma from occult primary constitute about 2-5% of all patients with carcinoma of unknown primary site (CUP).
  • The diagnostic procedures include physical examination with thorough evaluation of the head and neck mucosa using fiber-optic endoscopy, biopsies from all suspicious sites or blindly from the sites of possible origin of the primary, computer tomography and/or magnetic resonance.
  • The thoracic primary (tracheal, bronchial, lung, esophagus) has to be excluded, especially in the case of lower neck involvement.
  • Positron emission tomography (PET) with fluoro-2-deoxy-D-glucose allows detection of primary tumor in about 25% of cases, but this procedure is still considered investigational.
  • Therapeutic approaches include surgery (lymph node excision or neck dissection), with or without postoperative radiotherapy, radiotherapy alone and radiotherapy followed by surgery.
  • The role of other methods, such as chemotherapy and hyperthermia, remains to be determined.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / pathology. Lymph Nodes / pathology. Neoplasms, Unknown Primary / pathology
  • [MeSH-minor] Humans. Lymph Node Excision. Lymphatic Metastasis. Neck. Prognosis. Treatment Failure

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  • (PMID = 15023433.001).
  • [ISSN] 0305-7372
  • [Journal-full-title] Cancer treatment reviews
  • [ISO-abbreviation] Cancer Treat. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 91
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9. Kagawa S, Ohtani S, Tanaka N, Fujiwara T: [A case of advanced non-small lung cancer responding to tumor suppressor p53 gene therapy]. Gan To Kagaku Ryoho; 2004 Oct;31(11):1788-90
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  • [Title] [A case of advanced non-small lung cancer responding to tumor suppressor p53 gene therapy].
  • The phase I study of the tumor suppressor p53 gene therapy for advanced lung cancer was performed.
  • A 57-year-old man with locally advanced squamous cell carcinoma at the tracheal bifurcation, clinical stage IIIB, had previously been treated by radiotherapy and chemotherapy.
  • He was treated by a local injection of ADVEXIN once every 4 weeks for 14 times without marked adverse events, which resulted in tumor regression and relief of his symptom for a year.
  • In conclusion, gene therapy with ADVEXIN may be an effective treatment for locally advanced non-small lung cancer.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / therapy. Carcinoma, Squamous Cell / therapy. Genes, p53 / genetics. Genetic Therapy. Lung Neoplasms / therapy
  • [MeSH-minor] Humans. Male. Middle Aged. Treatment Outcome


10. Webb BD, Walsh GL, Roberts DB, Sturgis EM: Primary tracheal malignant neoplasms: the University of Texas MD Anderson Cancer Center experience. J Am Coll Surg; 2006 Feb;202(2):237-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary tracheal malignant neoplasms: the University of Texas MD Anderson Cancer Center experience.
  • BACKGROUND: Primary malignant neoplasms of the trachea are very rare and data relating to them are limited.
  • This study was conducted to review the presentation, management, and outcomes of primary tracheal cancers at our institution, a large multidisciplinary cancer center.
  • STUDY DESIGN: Retrospective chart review was conducted for all patients found to have a pathologic diagnosis of primary tracheal malignancy.
  • RESULTS: Since 1945, 74 patients were diagnosed with primary tracheal cancers.
  • Among these, 34 (45.9%) were squamous cell carcinomas, 19 (25.7%) were adenoid cystic carcinomas, and 21 (28.4%) were of other histologic types.
  • Most patients (77.3%) were former or current smokers, particularly those with squamous cell carcinoma (93.3%).
  • Patients who had adenoid cystic carcinoma and those with cervical primaries had better rates of disease-specific and overall survival than others (p = 0.036 and 0.006 for the former patient group and p = 0.006 and 0.030 for the latter patient group).
  • Among patients with incident disease treated at our institution (n = 45), those undergoing primary operation with adjuvant radiotherapy appeared to have better disease-specific and overall survival rates compared with those undergoing primary radiotherapy with or without chemotherapy (p = 0.0002 and 0.0003, respectively).
  • CONCLUSIONS: Primary tracheal cancers are very rare, and our results should be viewed with caution, given that our population comprised a small heterogeneous group treated over a 60-year period.
  • Although squamous cell carcinoma was the most common pathology in smokers, adenoid cystic carcinoma was more prevalent among nonsmokers.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / pathology. Tracheal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Comorbidity. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Smoking / epidemiology. Survival Analysis

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  • (PMID = 16427548.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Palanivelu C, Prakash A, Senthilkumar R, Senthilnathan P, Parthasarathi R, Rajan PS, Venkatachlam S: Minimally invasive esophagectomy: thoracoscopic mobilization of the esophagus and mediastinal lymphadenectomy in prone position--experience of 130 patients. J Am Coll Surg; 2006 Jul;203(1):7-16
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  • Most series report thoracoscopic mobilization of the esophagus and mediastinal lymphadenectomy in the left lateral position with respiratory complications up to 8% and prolonged operative time, probably because of inadequate stance of the surgeon during the thoracoscopic part.
  • This study shows the potential of the thoracoscopic part of the procedure in prone position to ease these difficulties.
  • All patients had histologically proved squamous cell carcinoma of the middle third of the esophagus.
  • Only one (0.77%) patient received neoadjuvant chemotherapy.
  • The thoracoscopic part of the procedure was performed in prone position with excellent ergonomics, translating into less operative time and better respiratory results.
  • There was no incidence of tracheal or lung injury and a very low incidence of postoperative pneumonia.
  • CONCLUSIONS: TLE with thoracoscopic part in prone position is technically feasible, with a low incidence of respiratory complications and less operative time required.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / surgery. Esophagectomy / methods. Lymph Node Excision / methods. Thoracoscopy
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Humans. Male. Mediastinum. Middle Aged. Prone Position. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 16798482.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Spásová I, Petera J: Long-term clinical benefits of the low dose rate endobronchial irradiation of malignant airway obstructions. Neoplasma; 2001;48(3):234-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of our study was to evaluate the long-term clinical survival in patients with malignant airway compromise treated with endobronchial brachytherapy and to estimate possible influence of other factors on survival and to review complications of the therapy.
  • In a retrospective study 55 patients with malignant inoperable tracheobronchial lesions underwent 71 brachytherapy treatments with 137Cesium.
  • All except 4 patients received external radiation, 20 patients received chemotherapy, 37 patients received laser excision.
  • Significant bleeding was observed in 1 procedure and an inability to tolerate in 3 cases.
  • Bronchomediastinal fistula developed in 1 patient and tracheal stenosis in 1 patient.
  • The median survival from establishing the diagnosis was 510 days.
  • The median survival after the first brachytherapy treatment was 200 days.
  • We compared the survival in the subgroups of patients in relation to TNM status, chemotherapy, laser debulking brachytherapy device used.
  • The stage IIIA patients survived longer from diagnosis than IIIB patients but the difference was on the border of significance (p = 0.090).
  • In the evaluation of chemotherapy, more patients survived 12 months from the diagnosis (p = 0.045) when treated by chemotherapy comparing to the patients treated without chemotherapy.
  • In the Nd-YAG laser treatment, the patients treated by brachytherapy with the previous laser debulking survived significantly longer from the time of the first brachytherapy session (p = 0.005).
  • In our group of patients, the long-term survival was longer in IIIA stage comparing to the IIIB, in the group treated by the previous chemotherapy compared to the patients without chemotherapy and in the group with the Nd-YAG laser therapy, comparing to the group treated by the brachytherapy only.
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Adult. Aged. Bronchial Neoplasms / mortality. Bronchial Neoplasms / pathology. Bronchial Neoplasms / radiotherapy. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiotherapy. Cesium Radioisotopes / therapeutic use. Dose-Response Relationship, Radiation. Female. Humans. Male. Middle Aged. Neoplasm Staging. Palliative Care. Retrospective Studies. Survival Analysis. Tracheal Neoplasms / mortality. Tracheal Neoplasms / pathology. Tracheal Neoplasms / radiotherapy. Treatment Outcome

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  • (PMID = 11583295.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Cesium Radioisotopes
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13. Bast F, Risteska K, Jovanovic S, Sedlmaier B: [The topical application of mitomycin C in the treatment of scar formation and stenosis in hollow organs of the head and neck: a field report]. Laryngorhinootologie; 2009 Aug;88(8):528-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The topical application of mitomycin C in the treatment of scar formation and stenosis in hollow organs of the head and neck: a field report].
  • Besides its use as an adjunction in the treatment of breast, lung and prostate cancer, or as a second-line cytostatic drug for head and neck squamous cell carcinoma (HNSCC), since 1963, MMC has also been successfully used in the suppression of post-operative scar formation, particularly in the field of ophthalmology.
  • In this résumé, we wish to recapitulate our long years of experience in the topical application of Mitomycin C in the treatment of scar formation and stenosis in head and neck organs.
  • The fields of application included laryngeal, tracheal, oesophageal stenosis and stenosis of the external ear canal and the choane.
  • RESULTS: After combined application of MMC and surgical intervention in cases of recurrent stenosising processes in head and neck organs, especially the larynx and the trachea, a sustained improvement was achieved in the pre-operative stenosis level as well as in the pre-operative, severely limited, forced inspiratory volume in 1 second (F1V1).
  • CONCLUSION: The topical application of MMC appears to be an effective adjunction as a concept of treatment for stenosising, scar-forming lesions.
  • This topical application, however, is not a substitute for correct diagnosis and appropriate surgical treatment.
  • [MeSH-major] Airway Obstruction / drug therapy. Antibiotics, Antineoplastic / administration & dosage. Cicatrix / drug therapy. Mitomycin / administration & dosage. Postoperative Complications / drug therapy
  • [MeSH-minor] Administration, Topical. Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Combined Modality Therapy. Female. Humans. Inspiratory Capacity / drug effects. Laryngoscopy. Laryngostenosis / diagnosis. Laryngostenosis / drug therapy. Laryngostenosis / surgery. Laser Therapy. Male. Middle Aged. Recurrence. Reoperation. Retreatment. Retrospective Studies. Tracheal Stenosis / diagnosis. Tracheal Stenosis / drug therapy. Tracheal Stenosis / surgery

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 19554503.001).
  • [ISSN] 1438-8685
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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14. Benhidjeb T, Moesta KT, Schlag PM: [Staging and neoadjuvant therapy of squamous cell carcinoma of esophagus]. Ther Umsch; 2001 Mar;58(3):165-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Staging and neoadjuvant therapy of squamous cell carcinoma of esophagus].
  • [Transliterated title] Staging und neoadjuvante Therapie des Plattenepithelkarzinoms des Osophagus.
  • Once the diagnosis of esophageal cancer is established, the decision on treatment will depend on the stage of the disease.
  • Since improvement of prognosis can only be expected in patients with complete removal of their tumor, preoperative staging plays a pivotal role in the decision-making process.
  • Preoperative diagnostic procedures should define the tumor in its relation to the tracheal bifurcation (site), determine the depth of tumor invasion (T status), evaluate regional lymph node metastases (N1 disease) and exclude distant metastases (M1 disease).
  • A higher accuracy rate may be achieved by combining endosonography with other staging modalities such as computed tomography.
  • Computed tomography (neck, chest and abdomen) is currently the best method to detect metastases in the liver and in celiac nodes.
  • Staging laparoscopy when combined with laparoscopic ultrasonography shows a higher sensitivity than ultrasonography and computed tomography in the diagnosis of smaller metastases and peritoneal seedings.
  • En bloc esophagectomy together with the regional lymph nodes remains the treatment of choice in medically fit patients with localized esophageal carcinoma (Stage I-IIB, T1-T2/N0-N1/M0).
  • Due to early involvement of mediastinal structures, curative resection is unlikely to be achieved in patients with locally advanced esophageal carcinoma (Stage III, T3-T4/N0-N1/M0).
  • At present, neoadjuvant therapy is still experimental and there is no consensus for an optimal treatment regimen.
  • Future research must focus on more effective and less toxic neoadjuvant modalities (e.g. new chemotherapy agents, hyperthermia).
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Esophageal Neoplasms / therapy. Neoadjuvant Therapy / methods
  • [MeSH-minor] Combined Modality Therapy. Humans. Neoplasm Seeding. Neoplasm Staging. Randomized Controlled Trials as Topic

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  • (PMID = 11305155.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 30
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15. Wen SL, Zhou X, Hu HH, Peng ZZ: [Clinical characteristics of 8 cases of primary tracheal tumors]. Zhonghua Jie He He Hu Xi Za Zhi; 2009 Sep;32(9):660-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical characteristics of 8 cases of primary tracheal tumors].
  • OBJECTIVE: To explore the clinical characteristics of primary tracheal tumors and therefore to improve the diagnosis and treatment.
  • METHODS: A retrospective analysis of the clinical data of 8 patients with primary tracheal tumors admitted to our department during the period of May 1994 to May 2006 was performed, with detailed description of the clinical manifestations, chest radiography, fiberoptic bronchoscopy, lung function measurements, treatment and prognosis for 4 cases.
  • Examination by fiberoptic bronchoscopy confirmed the diagnosis of tracheal tumor in all the cases.
  • Two cases of squamous cell carcinoma with severe tracheal stenosis got rapid symptom remission after intervention of tracheal stent by fiberoptic bronchoscopy and argon plasma coagulation.
  • One patient with adenoid cystic carcinoma refused any treatment.
  • One patient with squamous cell carcinoma lost follow-up after surgery.
  • One patient with adenocarcinoma died of progressive deterioration after 2 month chemotherapy.
  • CONCLUSIONS: Primary tracheal tumors occur infrequently and early clinical symptoms are unspecific.
  • Early diagnosis can be made by chest CT and fiberoptic bronchoscopy.
  • Benign tracheal tumors can be resected, and for some low-grade malignant tumors surgical resection and postoperative radiotherapy can improve long term survival.
  • [MeSH-major] Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / therapy. Tracheal Neoplasms / diagnosis. Tracheal Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Adult. Aged. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 20079278.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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16. Futami R, Tajiri T, Miyashita M, Maruyama H, Makino H, Nomura T, Tateno A, Miyashita T, Sasajima K: [Effect of nedaplatin, 5-FU, and leucovorin combined with radiation therapy in unresectable esophageal carcinoma]. Gan To Kagaku Ryoho; 2003 May;30(5):681-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effect of nedaplatin, 5-FU, and leucovorin combined with radiation therapy in unresectable esophageal carcinoma].
  • A 51-year-old male was assessed as having esophageal squamous cell carcinoma with trachea invasion and cervical lymph node metastasis.
  • After one course of chemotherapy using cisplatin (CDDP), 5-fluorouracil (5-FU) and Leucovorin (LV), the patient had progressive disease (PD) of the primary lesion and metastatic lymph nodes, and a side effect of severe nausea.
  • More information is needed as to whether changes in s-VEGF relate to the clinical effects of the treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / radiotherapy
  • [MeSH-minor] Combined Modality Therapy. Drug Administration Schedule. Endothelial Growth Factors / blood. Fluorouracil / administration & dosage. Humans. Intercellular Signaling Peptides and Proteins / blood. Leucovorin / administration & dosage. Lymphatic Metastasis. Lymphokines / blood. Male. Middle Aged. Organoplatinum Compounds / administration & dosage. Tracheal Neoplasms / pathology. Vascular Endothelial Growth Factor A. Vascular Endothelial Growth Factors

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  • (PMID = 12795101.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Endothelial Growth Factors; 0 / Intercellular Signaling Peptides and Proteins; 0 / Lymphokines; 0 / Organoplatinum Compounds; 0 / Vascular Endothelial Growth Factor A; 0 / Vascular Endothelial Growth Factors; 8UQ3W6JXAN / nedaplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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17. Riedel M, Stein HJ, Mounyam L, Zimmermann F, Fink U, Siewert JR: Influence of simultaneous neoadjuvant radiotherapy and chemotherapy on bronchoscopic findings and lung function in patients with locally advanced proximal esophageal cancer. Am J Respir Crit Care Med; 2000 Nov;162(5):1741-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of simultaneous neoadjuvant radiotherapy and chemotherapy on bronchoscopic findings and lung function in patients with locally advanced proximal esophageal cancer.
  • To assess the bronchoscopic and lung function changes induced by preoperative radiochemotherapy (30 Gy radiation and 5-fluorouracil) in patients with proximal esophageal cancer, we prospectively compared the findings in 77 consecutive patients before and after the therapy.
  • Of the 13 patients who developed apparent direct macroscopic signs of tumor invasion into the airways during therapy, histologic proof of cancer was obtained in only one of the abnormalities.
  • Neoadjuvant therapy led to no systematic changes in the appearance of the uninvolved tracheal mucosa; microscopically, an increase in postinflammatory changes, hyperplasia, and metaplasia was found.
  • There was no significant change in the values of lung function parameters after the therapy.
  • No patient developed symptoms suggestive of radiation-induced lung changes, although in one of them, subtle radiologic features consistent with radiation pneumonitis were found.
  • The interpretation of bronchoscopy in the assessment of airway invasion of esophageal cancer after radiochemotherapy is more difficult than at baseline staging; the positive predictive value of macroscopic abnormalities without microscopic proof of cancer is low, and even with extensive sampling for histology and cytology, the procedure was falsely negative in 9.4%.
  • Neoadjuvant therapy did not induce radiation pneumonitis or changes in lung function that could be of concern at the following operation.
  • [MeSH-major] Bronchoscopy. Carcinoma, Squamous Cell / therapy. Esophageal Neoplasms / therapy. Respiratory Mechanics
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Radiotherapy, Adjuvant

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  • (PMID = 11069806.001).
  • [ISSN] 1073-449X
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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18. Siewert JR, Ott K: Are squamous and adenocarcinomas of the esophagus the same disease? Semin Radiat Oncol; 2007 Jan;17(1):38-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are squamous and adenocarcinomas of the esophagus the same disease?
  • Esophageal cancer can be divided in squamous-cell cancer (SCC) and adenocarcinoma (Barrett cancer: AEG I) by histopathology.
  • The localization of AEG I is in 94% below the tracheal bifurcation, whereas SCC has contact to the tracheal bronchial tree in 75%.
  • The different localization and different comorbidities require different therapeutic strategies.
  • The preoperative induction therapy consists of combined chemoradiotherapy for locally advanced SCC and of chemotherapy for AEG I in our department.
  • Due to the favorable position of AEG I a classic Ivor-Lewis procedure ending with an intrathoracic anastomosis is possible, in contrast, SCC frequently requires a subtotal esophagectomy with cervical anastomosis (in a two step strategy).
  • Therefore, at the moment there is no doubt that SCC and AEG I are two different diseases with different pathogenesis, epidemiology, tumor biology and prognosis requiring different therapeutic strategies.
  • [MeSH-major] Adenocarcinoma / therapy. Carcinoma, Squamous Cell / therapy. Esophageal Neoplasms / therapy

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  • (PMID = 17185196.001).
  • [ISSN] 1053-4296
  • [Journal-full-title] Seminars in radiation oncology
  • [ISO-abbreviation] Semin Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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19. Thotathil ZS, Agarwal JP, Shrivastava SK, Dinshaw KA: Primary malignant tumors of the trachea - the Tata Memorial Hospital experience. Med Princ Pract; 2004 Mar-Apr;13(2):69-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary malignant tumors of the trachea - the Tata Memorial Hospital experience.
  • OBJECTIVE: Primary tumors of the trachea are extremely rare.
  • Treatment methods vary considerably and few studies have sought to provide adequate guidelines.
  • This study reviews the records of patients treated for tracheal cancer at the Tata Memorial Hospital (TMH), Mumbai, India.
  • SUBJECTS AND METHODS: Fifteen patients with primary tracheal malignancies were identified in the TMH database during the period from 1983 to 2000.
  • Squamous cell carcinoma was the commonest histologic subtype (40%) followed by adenoid cystic carcinoma (27%).
  • Ten patients received radical treatment.
  • Another was explored but was found to be unresectable and was 1 of 2 patients treated with chemotherapy and radiotherapy.
  • The majority of patients (8/9) were treated with locoregional fields and doses ranging from 40 to 60 Gy (median 50 Gy).
  • Two patients also received intraluminal brachytherapy, 1 as part of initial treatment and another for recurrence.
  • Follow-up times ranged from 1 month to 134 months, median of 38 months.
  • CONCLUSION: Tracheal cancer is a rare malignancy.
  • Radiation therapy is a reasonably effective modality for unresectable disease.
  • [MeSH-major] Tracheal Neoplasms / epidemiology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Kuwait / epidemiology. Male. Middle Aged. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright 2004 S. Karger AG, Basel
  • (PMID = 14755137.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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20. Veronesi G, Solli PG, Leo F, D'Aiuto M, Pelosi G, Leon ME, De Braud F, Spaggiari L, Pastorino U: Low morbidity of bronchoplastic procedures after chemotherapy for lung cancer. Lung Cancer; 2002 Apr;36(1):91-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low morbidity of bronchoplastic procedures after chemotherapy for lung cancer.
  • OBJECTIVE: To evaluate if induction chemotherapy, with or without irradiation, represents an additional risk factor for early and late morbidity and perioperative mortality in bronchoplastic procedures for lung cancers.
  • METHODS: From January 1998 to January 2001, 27 patients underwent a bronchial sleeve resection after induction treatment at the European Institute of Oncology in Milan.
  • They represent 7% of lung cancer resections (387) and 27% of those performed after neoadjuvant treatment (100 cases).
  • Histology was: 17 epidermoid carcinoma, 8 adenocarcinoma and 2 SCLC.
  • Twenty-four patients (89%) received a preoperative cisplatin based polichemotherapy, and three cases (11%) a chemo-radiation therapy.
  • A resection of tracheal carina was associated in three cases and a vascular resection in 10 (five vena cava and five pulmonary artery).
  • Perioperative morbidity of the study group (group 1) was compared with that of patients submitted to sleeve resection without neoadjuvant treatment (group 2), or standard pneumonectomy after induction treatment (group 3).
  • Only one late anastomotic stricture occurred after postoperative radiation treatment.
  • CONCLUSIONS: Preoperative chemotherapy or combination of chemo-radio therapy is not associated with an additional risk of anastomotic complications in bronco and angioplastic procedures.
  • Parenchyma sparing resection is a valid option for selected patients with locally advanced lung cancer after induction treatment.
  • A longer follow up is necessary to evaluate efficacy of the procedure in term of survival and local control.
  • [MeSH-major] Cisplatin / therapeutic use. Deoxycytidine / analogs & derivatives. Lung Neoplasms / drug therapy. Lung Neoplasms / surgery. Pneumonectomy / methods
  • [MeSH-minor] Adult. Aged. Carcinoma, Non-Small-Cell Lung / drug therapy. Carcinoma, Non-Small-Cell Lung / radiotherapy. Carcinoma, Non-Small-Cell Lung / surgery. Carcinoma, Small Cell / drug therapy. Carcinoma, Small Cell / radiotherapy. Carcinoma, Small Cell / surgery. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Female. Humans. Lymph Node Excision. Male. Mediastinum / radiation effects. Middle Aged. Neoplasm Staging. Prospective Studies. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 11891039.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
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21. Maier A, Tomaselli F, Matzi V, Woltsche M, Anegg U, Fell B, Rehak P, Pinter H, Smolle-Jüttner FM: Comparison of 5-aminolaevulinic acid and porphyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study. Lasers Surg Med; 2002;30(1):12-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of 5-aminolaevulinic acid and porphyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study.
  • BACKGROUND AND OBJECTIVES: Photosan, a mixture of porphyrin oligomers as sensitizer for photodynamic therapy (PDT), carry the risk of prolonged photosensitivity of the skin.
  • [MeSH-major] Aminolevulinic Acid / therapeutic use. Bronchial Diseases / drug therapy. Lung Neoplasms / complications. Photochemotherapy. Photosensitizing Agents / therapeutic use. Porphyrins / therapeutic use. Tracheal Stenosis / drug therapy
  • [MeSH-minor] Adenocarcinoma / complications. Aged. Carcinoma, Squamous Cell / complications. Constriction, Pathologic / drug therapy. Constriction, Pathologic / etiology. Dyspnea / etiology. Female. Hematoporphyrins. Humans. Hyperbaric Oxygenation. Male. Middle Aged. Palliative Care. Pilot Projects. Prospective Studies. Survival Rate

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  • [Copyright] Copyright 2002 Wiley-Liss, Inc.
  • (PMID = 11857598.001).
  • [ISSN] 0196-8092
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hematoporphyrins; 0 / Photosensitizing Agents; 0 / Porphyrins; 136219-06-2 / photosan III; 88755TAZ87 / Aminolevulinic Acid
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22. Ishiyama T, Aoyama T, Hirahara H, Iwashima A, Tsukada H, Souma T: [Successful resection of endotracheal metastatic lung cancer using percutaneous cardiopulmonary support system: a case report]. Kyobu Geka; 2001 Jan;54(1):19-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We experienced a rare case of endotracheal metastasis derived from squamous cell lung cancer.
  • Pathological diagnosis indicated stage IIB and he underwent two cycles of chemotherapy with CDDP + VDS.
  • Bronchofiberoptic examination showed same as CT finding and its brushing cytology confirmed squamous cell carcinoma.
  • Majority of the reported cases of endotracheal metastases were treated conservatively as radiation, laser and/or chemotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Cardiopulmonary Bypass / methods. Trachea / surgery. Tracheal Neoplasms / secondary. Tracheal Neoplasms / surgery
  • [MeSH-minor] Humans. Lung Neoplasms / pathology. Male. Middle Aged. Reconstructive Surgical Procedures. Treatment Outcome

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  • (PMID = 11197904.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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23. Genden EM, Kaufman MR, Katz B, Vine A, Urken ML: Tubed gastro-omental free flap for pharyngoesophageal reconstruction. Arch Otolaryngol Head Neck Surg; 2001 Jul;127(7):847-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • As a result of the current treatment paradigms for advanced laryngopharyngeal cancers, it is common that the surgical field has been previously irradiated or exposed to systemic chemotherapy, resulting in fistula rates as high as 78% and mortality as high as 8%.
  • The free vascularized tubed gastric antrum and the accompanying greater omentum offer a single-staged method of pharyngoesophageal reconstruction, with the added benefit of protection of the great vessels, the tracheal stump, and the mediastinal contents in a high-risk surgical field.
  • OBJECTIVE: To assess the gastro-omental free flap as a method of pharyngoesophageal reconstruction in patients who have been previously treated with multimodality therapy.
  • Five patients had received previous external beam irradiation, 2 had received systemic chemotherapy, and 4 had undergone previous surgery.
  • CONCLUSION: The tubed gastro-omental free flap offers a safe method of reconstructing the pharyngoesophageal segment in a surgical field compromised by previous multimodality therapy.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / surgery. Esophagectomy / methods. Fibrosarcoma / surgery. Laryngectomy / methods. Liposarcoma / surgery. Pharyngeal Neoplasms / surgery. Pharyngectomy / methods. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Postoperative Complications / etiology. Retrospective Studies

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  • (PMID = 11448362.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Suzuki T, Akizawa T, Suzuki H, Kitazume K, Omine M, Mitsuya T: Primary tracheal mucosa-associated lymphoid tissue lymphoma accompanying lung cancer. Common tumorigenesis or coincidental coexistence? Jpn J Thorac Cardiovasc Surg; 2000 Dec;48(12):817-9
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  • [Title] Primary tracheal mucosa-associated lymphoid tissue lymphoma accompanying lung cancer. Common tumorigenesis or coincidental coexistence?
  • We report a 67-year-old patient with coexistent tracheal non-Hodgkin's lymphoma and lung cancer the first case, to our knowledge, of this concomitant incidence in the literature.
  • Biopsy of the unanticipated tracheal irregularity revealed non-Hodgkin's lymphoma, compatible with mucosa-associated lymphoid tissue lymphoma.
  • After right upper lobectomy, chemotherapy for non-Hodgkin's lymphoma was conducted, but the patient died 11 months postoperatively of pulmonary fibrosis.
  • Pulmonary fibrosis was suspected of having progressed from drug-induced pneumonitis caused by anticancer drugs.
  • A common tumorigenetic factor may thus exist between tracheobronchial mucosa-associated lymphoid tissue lymphoma and lung cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Lung Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, Non-Hodgkin / pathology. Neoplasms, Multiple Primary. Tracheal Neoplasms / pathology

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  • (PMID = 11197829.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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25. Brücher BL, Weber W, Bauer M, Fink U, Avril N, Stein HJ, Werner M, Zimmerman F, Siewert JR, Schwaiger M: Neoadjuvant therapy of esophageal squamous cell carcinoma: response evaluation by positron emission tomography. Ann Surg; 2001 Mar;233(3):300-9
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  • [Title] Neoadjuvant therapy of esophageal squamous cell carcinoma: response evaluation by positron emission tomography.
  • OBJECTIVE: To evaluate the use of positron emission tomography using [(18)F]-fluorodeoxyglucose (FDG-PET) to assess the response to neoadjuvant radiotherapy and chemotherapy in patients with locally advanced esophageal cancer.
  • SUMMARY BACKGROUND DATA: Imaging modalities, including endoscopy, endoscopic ultrasound, computed tomography, and magnetic resonance imaging, currently used to evaluate response to neoadjuvant treatment in esophageal cancer do not reliably differentiate between responders and nonresponders.
  • METHODS: Twenty-seven patients with histopathologically proven squamous cell carcinoma of the esophagus, located at or above the tracheal bifurcation, underwent neoadjuvant therapy consisting of external-beam radiotherapy and 5-fluorouracil as a continuous infusion.
  • FDG-PET was performed before and 3 weeks after the end of radiotherapy and chemotherapy (before surgery).
  • RESULTS: After neoadjuvant therapy, 24 patients underwent surgery.
  • CONCLUSION: FDG-PET is a valuable tool for the noninvasive assessment of histopathologic tumor response after neoadjuvant radiotherapy and chemotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / radionuclide imaging. Carcinoma, Squamous Cell / therapy. Esophageal Neoplasms / radionuclide imaging. Esophageal Neoplasms / therapy. Fluorodeoxyglucose F18. Neoadjuvant Therapy. Tomography, Emission-Computed
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Prospective Studies. Radiopharmaceuticals. Radiotherapy, Adjuvant. Survival Analysis. Treatment Outcome

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  • (PMID = 11224616.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC1421244
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26. Smith JE, Suh JD, Erman A, Nabili V, Chhetri DK, Blackwell KE: Risk factors predicting aspiration after free flap reconstruction of oral cavity and oropharyngeal defects. Arch Otolaryngol Head Neck Surg; 2008 Nov;134(11):1205-8
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  • MAIN OUTCOME MEASURES: Dysphagia severity was assessed by modified barium swallow study performed within 90 days after surgery to determine the presence or absence of tracheal aspiration.
  • Aspiration risk factors analyzed included age; sex; tumor T and N stage; comorbidity level (American Society of Anesthesiologists classification); preoperative swallowing function; history of tobacco use; surgical approach used for tumor resection; defect classification; type of free flap; history of radiation therapy, surgery, and/or chemotherapy; and surgical defect classification.
  • RESULTS: The following risk factors were significant predictors of postoperative aspiration on univariate analysis: prior radiation therapy (P < .001), tongue base resection classification (P = .001), tumor N stage (P < .001), hypoglossal nerve sacrifice (P = .004), and presence of a mandibular osteotomy (P = .01).
  • On multivariate analysis, only a history of radiation therapy (P = .002) and tongue base resection (P = .008) remained statistically significant predictors of aspiration.
  • CONCLUSION: Patients with resection of more than half of the tongue base and patients with a history of radiation therapy are at high risk of having early postoperative aspiration after free flap reconstruction.
  • [MeSH-major] Ameloblastoma / surgery. Carcinoma, Squamous Cell / surgery. Mouth Neoplasms / surgery. Oropharyngeal Neoplasms / surgery. Postoperative Complications / etiology. Respiratory Aspiration / etiology. Surgical Flaps
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Deglutition Disorders / etiology. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Retrospective Studies. Risk Factors

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  • (PMID = 19015452.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Imauchi Y, Ito K, Takasago E, Nibu K, Sugasawa M, Ichimura K: Stomal recurrence after total laryngectomy for squamous cell carcinoma of the larynx. Otolaryngol Head Neck Surg; 2002 Jan;126(1):63-6
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  • [Title] Stomal recurrence after total laryngectomy for squamous cell carcinoma of the larynx.
  • OBJECTIVE: Stomal recurrence after total laryngectomy is one of the most serious issues in the management of laryngeal carcinoma.
  • The management of stomal recurrence, including chemotherapy, radiotherapy, and surgery, has been reported as unsatisfactory.
  • STUDY DESIGN AND SETTING: From 1985 to 1995, 69 patients underwent total laryngectomy for the treatment of laryngeal cancer at the University of Tokyo Hospital.
  • RESULTS: Stomal recurrence developed in 6 of 69 patients who underwent total laryngectomy for laryngeal carcinoma.
  • CONCLUSION: Intensive follow-up should be performed for patients with glottic carcinoma who had preoperative tracheotomy, paratracheal lymph node metastasis, or both to detect stomal recurrence at an early stage.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Laryngeal Neoplasms / surgery. Laryngectomy. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Preoperative Care. Risk Factors. Salvage Therapy. Tracheal Neoplasms / diagnosis. Tracheal Neoplasms / epidemiology. Tracheal Neoplasms / secondary. Tracheotomy

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  • (PMID = 11821768.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Satyanarayana S, Pathak SD, Saraswat V, Sarma YS, Bharadwaj R, Goorha YK: Tracheal lymphoepithelioma-like carcinoma: a case report. Indian J Cancer; 2002 Jul-Sep;39(3):112-5
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  • [Title] Tracheal lymphoepithelioma-like carcinoma: a case report.
  • Lymphoepithelioma like carcinoma is rare in locations other than nasopharynx.
  • We report the second case of this tumour in trachea, in a young female patient, who was managed with concomitent surgery, radiotherapy and chemotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Tracheal Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans

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  • (PMID = 12928566.001).
  • [ISSN] 0019-509X
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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29. Santos RS, Raftopoulos Y, Keenan RJ, Halal A, Maley RH, Landreneau RJ: Bronchoscopic palliation of primary lung cancer: single or multimodality therapy? Surg Endosc; 2004 Jun;18(6):931-6
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  • [Title] Bronchoscopic palliation of primary lung cancer: single or multimodality therapy?
  • BACKGROUND: An obstructing primary lung cancer is a challenging disease frequently requiring endobronchial interventional therapy.
  • A variety of interventional modalities, including Nd:YAG laser, stenting, photodynamic therapy (PDT), and endoluminal brachytherapy, are utilized to relieve airway obstruction and bleeding.
  • In 29 patients (42%) a multimodality endoscopic treatment was utilized (group B).
  • Single-modality treatment in group A included Nd-YAG laser in 60%, stent in 17%, brachytherapy in 20%, and PDT in 3%.
  • Patient data were compared with the Student's t-test and chi-square test.
  • The tumor was located in the trachea 9%, in the carina in 7%, and primary bronchial in 84%.
  • There was no significant difference between the two groups in relation to age, gender, tumor location, histology, and type of previous cancer therapy.
  • CONCLUSIONS: Improvement in survival can be seen with diligent airway surveillance after interventional bronchoscopy and liberal use of a variety of endobronchial treatment modalities for airway obstruction or bleeding.
  • Physicians involved in the management of this difficult problem should be versed in the use of all available treatment modalities to enhance therapeutic outcome.
  • [MeSH-major] Bronchoscopy. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery. Palliative Care / methods
  • [MeSH-minor] Aged. Airway Obstruction / etiology. Brachytherapy. Bronchial Neoplasms / complications. Bronchial Neoplasms / drug therapy. Bronchial Neoplasms / radiotherapy. Bronchial Neoplasms / surgery. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Combined Modality Therapy. Female. Hemoptysis / etiology. Humans. Laser Therapy. Life Tables. Male. Middle Aged. Photochemotherapy. Pneumonectomy. Retrospective Studies. Stents. Survival Analysis. Survival Rate. Tracheal Neoplasms / complications. Tracheal Neoplasms / drug therapy. Tracheal Neoplasms / radiotherapy. Tracheal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 15108108.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Review
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30. Venuta F, Rendina EA, De Giacomo T, Mercadante E, Ciccone AM, Aratari MT, Moretti M, Coloni GF: Endoscopic treatment of lung cancer invading the airway before induction chemotherapy and surgical resection. Eur J Cardiothorac Surg; 2001 Sep;20(3):464-7
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  • [Title] Endoscopic treatment of lung cancer invading the airway before induction chemotherapy and surgical resection.
  • OBJECTIVE: Many patients with advanced lung cancer invading the airway require only palliation; however, induction chemotherapy and surgery may sometimes be considered.
  • We reviewed our experience with preliminary laser treatment, induction chemotherapy and surgical resection in patients with lung cancer invading the airway.
  • METHODS: Twenty-one patients with stage IIIA and IIIB lung cancer presenting with an 80% unilateral airway obstruction were treated with laser resection, induction chemotherapy and surgery.
  • Spirometry, arterial blood gas analysis, quality of life (QLQ-C30 score) and performance status were recorded before and after laser treatment and after chemotherapy.
  • Complications during chemotherapy, surgical morbidity and mortality, and survival were also recorded.
  • RESULTS: No complications were observed after endoscopic treatment.
  • FEV(1) significantly improved from 1.4+/-0.4 l/s to 2.2+/-0.7 l/s, as well as FVC (from 2+/-0.5 to 3.1+/-0.8 l), and remained stable after chemotherapy.
  • The QLQ-C30 score significantly improved after laser treatment (from 45+/-4.8 to 31+/-2.5) as well as the Karnofsky status (from 76+/-5 to 90).
  • One patient developed pneumonia during induction chemotherapy.
  • We performed five pneumonectomies (one right tracheal sleeve pneumonectomy) and 13 lobectomies (five associated to a bronchial sleeve resection).
  • CONCLUSIONS: Preliminary endoscopic palliation of lung cancer invading the airway is feasible, improves evaluation and staging, helps to reduce the incidence of complications during induction chemotherapy without increasing surgical morbidity and mortality.
  • [MeSH-major] Adenocarcinoma / surgery. Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / therapy. Endoscopy. Laser Therapy. Lung Neoplasms / therapy. Palliative Care. Pneumonectomy
  • [MeSH-minor] Aged. Airway Obstruction / etiology. Bronchi / pathology. Bronchi / surgery. Combined Modality Therapy. Female. Forced Expiratory Volume. Humans. Male. Middle Aged. Neoplasm Invasiveness. Survival Rate






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