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1. Chang AR, Wu HG, Park CI, Kim KH, Sung MW, Heo DS: Retrospective analysis of the treatment results for patients with squamous cell carcinoma of tonsil. Cancer Res Treat; 2005 Apr;37(2):92-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrospective analysis of the treatment results for patients with squamous cell carcinoma of tonsil.
  • PURPOSE: There has been no definitive randomized study to identify the optimal therapeutic regimen for treating squamous cell carcinoma of tonsil.
  • The purpose of this study was to retrospectively evaluate the treatment outcome according to various combinations of surgery, radiation therapy and chemotherapy.
  • MATERIALS AND METHODS: Fifty-six patients with tonsillar carcinoma, who were treated at Seoul National University Hospital from March 1985 to August 2001, were the subjects of this study.
  • Twenty-one patients received surgery followed by radiation therapy (SRT), 16 patients underwent radiation therapy alone (RT), and 19 patients received neoadjuvant chemotherapy and radiation therapy (CRT).
  • The median radiation dose was 66.6 Gy for the SRT group and 70.2 Gy for the RT and CRT groups.
  • RESULTS: The distribution of T-stage was 4 cases of T1, 14 cases of T2, 1 case of T3 and 2 cases of T4 staging in the SRT group, 2 cases of T1, 6 cases of T2, 5 cases of T3 and 3 cases of T4 staging in the RT group and 0 cases of T1, 7 cases of T2, 9 cases of T3 and 3 cases of T4 staging in the CRT group.
  • The distribution of N-stage was 5 cases of N0, 2 cases of N1, 13 cases of N2 and 1 case of N3 staging in the SRT group, 6 cases of N0, 5 cases of N1, 5 cases of N2 and 0 cases of N3 staging in the RT group, and 2 cases of N0, and 7 cases of N1, 9 cases of N2 and 1 case of N3 staging in the CRT group.
  • Four patients developed local failure and one patient failed at a regional site in the RT group, and one patient failed at a primary site in the CRT group.
  • Treatment-related complications of grade 3 or 4 occurred in 15 patients, and the incidence of complication was not different between each of the treatment methods.
  • CONCLUSION: Although the patients with more advanced T stage were included in the RT and CRT groups, the OSR was not statistically different according to the treatment methods.
  • In the radical radiation therapy group, the addition of neoadjuvant chemotherapy showed an improvement in the disease-free survival.
  • Because of the retrospective nature of our study and the small number of patients, this study cannot draw any definite conclusions, but it suggests that radiation therapy with chemotherapy can be a good alternative option for squamous cell carcinoma of tonsil.

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  • (PMID = 19956486.001).
  • [ISSN] 2005-9256
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2785396
  • [Keywords] NOTNLM ; Chemotherapy / Radiation therapy / Squamous cell carcinoma of tonsil / Surgery
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2. Dominguez PA, Dervisis NG, Cadile CD, Sarbu L, Kitchell BE: Combined gemcitabine and carboplatin therapy for carcinomas in dogs. J Vet Intern Med; 2009 Jan-Feb;23(1):130-7
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  • [Title] Combined gemcitabine and carboplatin therapy for carcinomas in dogs.
  • BACKGROUND: Response and adverse reactions to combined gemcitabine (GEM) and carboplatin (CARBO) therapy in dogs with carcinomas are not documented.
  • HYPOTHESIS: GEM and CARBO are safe for the treatment of dogs with carcinomas.
  • Twelve dogs (32%) developed neutropenia (3 Grade 3, and 5 Grade 4) and 9 (24%) thrombocytopenia (2 Grade 3, and 1 Grade 4).
  • One dog died of treatment-related complications.
  • One dog with metastatic prostatic carcinoma achieved a complete remission and 1 dog with intestinal adenocarcinoma and 1 with tonsillar squamous cell carcinoma achieved partial remission.
  • CONCLUSION AND CLINICAL IMPORTANCE: GEM and CARBO combination causes mild to moderate hematologic and GI toxicosis in dogs with carcinoma.

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  • (PMID = 19175731.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin
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3. Prestwich RJ, Kancherla K, Oksuz DC, Williamson D, Dyker KE, Coyle C, Sen M: A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage IV tonsillar cancer. Radiat Oncol; 2010;5:121

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  • [Title] A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage IV tonsillar cancer.
  • BACKGROUND: Chemo-radiotherapy offers an alternative to primary surgery and adjuvant therapy for the management of locally advanced stage IV squamous cell carcinomas of the tonsil.
  • METHODS: A retrospective analysis was performed of the outcomes of 41 patients with locoregionally advanced squamous cell carcinoma of the tonsil treated non-surgically at the Yorkshire Cancer Centre between January 2004 and December 2005.
  • Due to long radiotherapy waiting times, patients received induction chemotherapy with cisplatin and 5-fluorouracil followed by either cisplatin concurrent chemoradiotherapy or radiotherapy alone.
  • 35/41 patients (85%) received 2 or more cycles of induction chemotherapy.
  • Following induction chemotherapy, 32/41 patients (78%) had a clinical response.
  • Concomitant chemotherapy was given to 30/41 (73%).
  • There were no treatment related deaths.
  • Six (15%) patients had gastrostomy tubes placed before treatment, and 22 (54%) required nasogastric tube placement during or after treatment for nutritional support.
  • 17 patients required unplanned admissions during treatment for supportive care.
  • At 4 months post treatment assessment 35 out of 41 (85%) patients achieved complete clinical and radiographic response.
  • CONCLUSION: Cisplatin-based induction and concurrent chemoradiotherapy provides excellent tumour control with acceptable toxicity for patients with locally advanced tonsillar cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Tonsillar Neoplasms / drug therapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant / methods. Combined Modality Therapy. Disease Progression. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant / methods. Retrospective Studies. Survival Analysis

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  • (PMID = 21176154.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3022575
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4. Hofmann U, O'Connor JP, Biyani CS, Harnden P, Selby P, Weston PM: Retroperitoneal metastatic squamous cell carcinoma of the tonsil (with elevated beta human chorionic gonadotrophin): a misdiagnosis as extra-gonadal germ cell tumour. J Laryngol Otol; 2006 Oct;120(10):885-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal metastatic squamous cell carcinoma of the tonsil (with elevated beta human chorionic gonadotrophin): a misdiagnosis as extra-gonadal germ cell tumour.
  • A case of retroperitoneal metastasis from a squamous cell carcinoma of the tonsil, secreting beta human chorionic gonadotrophin (beta-hCG), is reported.
  • A 58-year-old man had undergone a tonsillectomy and chemo-radiotherapy for squamous cell carcinoma of the left tonsil and 13 months later presented with non-specific abdominal pain.
  • A computed tomography scan demonstrated para-aortic retroperitoneal lymphadenopathy.
  • The initial pathological analysis was interpreted as extra-gonadal germ cell tumour and the patient received chemotherapy.
  • A subsequent review was consistent with a metastatic squamous cell carcinoma of the tonsil, as immunohistochemical studies showed positive staining for epithelial membrane antigen and cytokeratins 5/6 but a negative reaction to placental alkaline phosphatase.
  • Following this, the chemotherapy regimen was changed; however, a restaging scan demonstrated progression, and the patient died from aspiration pneumonia secondary to alcohol intoxication.
  • To our knowledge, this is the first reported case of retroperitoneal metastasis from a squamous cell carcinoma of the tonsil, secreting beta-hCG and causing hydronephrosis.
  • This case highlights the necessity of using clinical, histological, immunohistological and ultrastructural examination to establish precise diagnosis and to avoid inappropriate treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Diagnostic Errors. Neoplasms, Germ Cell and Embryonal / diagnosis. Retroperitoneal Neoplasms / diagnosis. Tonsillar Neoplasms

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  • (PMID = 16716237.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / Neoplasm Proteins
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5. Poulsen M, Porceddu SV, Kingsley PA, Tripcony L, Coman W: Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited. Laryngoscope; 2007 Jan;117(1):45-50
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  • [Title] Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited.
  • AIMS: The purpose of this study was to review the treatment policy for locally advanced stage III and IV squamous cell carcinoma (SCC) of the tonsil at the Princess Alexandra Hospital Head and Neck Unit, Brisbane, Australia.
  • MATERIALS AND METHODS: The records of 148 patients with curable stage III and IV SCC of the tonsil were reviewed from the years 1992 to 2004 inclusive.
  • During this period, patients were treated with surgery and postoperative radiotherapy and only offered definitive radiation if they were medically or surgically inoperable.
  • There were 102 patients treated with surgery +/- postoperative radiotherapy (group 1) and 46 patients treated with definitive radiotherapy +/- chemotherapy (group 2).
  • Multivariate analyses, which adjusted for known prognostic factors, showed that treatment group was significant for OS but not for LRC or DSS.
  • CONCLUSIONS: Surgery and postoperative radiotherapy continues to provide a superior outcome in locally advanced tonsil SCC in patients with surgically resectable disease, good ECOG performance status, and medically operable.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Tonsillar Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Prognosis. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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  • [CommentIn] Laryngoscope. 2007 Oct;117(10):1894-5; author reply 1895 [17906504.001]
  • (PMID = 17202929.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Mau T, Oh Y, Bucci MK, Eisele DW: Management of cervical metastases in advanced squamous cell carcinoma of the tonsillar fossa following radiotherapy. Arch Otolaryngol Head Neck Surg; 2005 Jul;131(7):600-4
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  • [Title] Management of cervical metastases in advanced squamous cell carcinoma of the tonsillar fossa following radiotherapy.
  • OBJECTIVE: To assess the value of planned neck dissection in patients with a complete response to definitive radiotherapy for squamous cell carcinoma of the tonsillar fossa with advanced nodal disease.
  • PATIENTS: A consecutive series of 36 patients with squamous cell carcinoma of the tonsillar fossa with N2 or N3 nodal disease treated with primary radiation therapy with or without concurrent chemotherapy between January 1, 1992, and April 1, 2003, at the University of California, San Francisco, Comprehensive Cancer Center.
  • Of the 15 patients with a complete response, only 2 (13%) later developed regional recurrences, 1 of which was an isolated recurrence in the neck.
  • CONCLUSIONS: The rate of regional recurrence after a complete response to radiation therapy with or without concurrent chemotherapy for tonsillar squamous cell carcinoma with advanced cervical metastases is low.
  • Our results support close surveillance of the neck in those who have achieved a complete response after radiation therapy with or without chemotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / therapy. Head and Neck Neoplasms / secondary. Head and Neck Neoplasms / therapy. Tonsillar Neoplasms / pathology. Tonsillar Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Survival Rate. Treatment Outcome

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  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
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  • (PMID = 16027282.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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7. Nieder C, Steen RE, Dalhaug A: A Challenging Picture of Cancer-and Inflammation-Related Changes. Clin Med Oncol; 2009;3:15-7

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  • The authors describe a diagnostically challenging case where a patient with previous squamous cell carcinoma of the tonsil developed a putative second primary squamous cell carcinoma in the lung (stage IV with lung and bone metastases).
  • During palliative chemotherapy several episodes of severe infection occurred, eventually resulting in abscess formation in the hip and brain.
  • The dilemma of distinguishing between metastasis and abscess and the therapeutic implications are discussed.

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  • (PMID = 20689606.001).
  • [ISSN] 1177-9314
  • [Journal-full-title] Clinical medicine. Oncology
  • [ISO-abbreviation] Clin Med Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2872603
  • [Keywords] NOTNLM ; abscess / brain metastases / head and neck cancer / lung cancer / metastasis
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8. Laccourreye O, Hans S, Ménard M, Garcia D, Brasnu D, Holsinger FC: Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: II. An analysis of the incidence, related variables, and consequences of local recurrence. Arch Otolaryngol Head Neck Surg; 2005 Jul;131(7):592-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: II. An analysis of the incidence, related variables, and consequences of local recurrence.
  • PATIENTS: A total of 166 previously untreated patients with squamous cell carcinoma of the tonsil.
  • INTERVENTIONS: A total of 131 (81.9%) of the 166 patients received preoperative induction chemotherapy.
  • Fifty-one patients (30.7%) underwent postoperative radiation therapy.
  • In univariate analysis, 7 variables were significantly associated with an increased risk of local failure: increasing T classification; positive margins of resection; poor clinical response to induction chemotherapy; tumor spread to the posterior pillar, posterior pharyngeal wall, and contralateral soft palate; and invasion of the junction between the tonsil and soft palate.
  • CONCLUSIONS: Selected tonsillar squamous cell carcinoma can be managed with TLO with local control comparable to radiotherapy.
  • Patient selection is critical and TLO is best suited for patients with anterior T1 to T2 squamous cell carcinoma of the tonsil, without posterior anatomic spread.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neoplasm Recurrence, Local. Oropharynx / surgery. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Logistic Models. Male. Middle Aged. Neoplasm Metastasis. Neoplasms, Second Primary. Otorhinolaryngologic Surgical Procedures / methods

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  • (PMID = 16027281.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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9. Naidu SI, Vieira F, Samant S, Vang MC, Wan AY, Robbins TK: Targeted intra-arterial chemoradiation for advanced tonsil cancer. Otolaryngol Head Neck Surg; 2005 Dec;133(6):882-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Targeted intra-arterial chemoradiation for advanced tonsil cancer.
  • OBJECTIVES: To determine the effects of combined radiation and targeted, intra-arterial (IA) cisplatin infusions (RADPLAT) in patients with advanced squamous cell carcinoma (SCC) of the tonsil.
  • STUDY DESIGN AND SETTING: Prospective study of treatment outcomes and toxicity of patients enrolled on the RADPLAT protocol, with specific analysis of patients with advanced SCC of the tonsil.
  • RESULTS: Thirty patients with advanced tonsil carcinoma (17 T(4), 12 T(3), 1 T(2)) were enrolled, and 24 of 30 patients completed at least 3 IA cisplatin infusions and a minimum of 63 Gy or radiation therapy (minimum therapy).
  • Two-year estimated overall and disease-specific survival was 42% and 50%, respectively, for all 30 patients (intent-to-treat group) and 49% and 58%, respectively, for the minimum therapy subgroup.
  • The 2-year estimated local and regional disease control was 87% and 90%, respectively, for the intent-to-treat group, and 100% and 90% for the minimum therapy subgroup.
  • CONCLUSIONS: Locoregional disease control achieved with this regimen appears to be significantly improved over that described in the literature for similarly staged tonsil cancer.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Cisplatin / therapeutic use. Tonsillar Neoplasms / drug therapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Biopsy. Female. Follow-Up Studies. Humans. Infusions, Intra-Arterial. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Radiotherapy, Adjuvant. Survival Rate. Treatment Outcome

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  • (PMID = 16360508.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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10. Moore EJ, Henstrom DK, Olsen KD, Kasperbauer JL, McGree ME: Transoral resection of tonsillar squamous cell carcinoma. Laryngoscope; 2009 Mar;119(3):508-15
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  • [Title] Transoral resection of tonsillar squamous cell carcinoma.
  • OBJECTIVES: The tonsillar fossa is the most common subsite of the oropharynx to be afflicted with squamous cell carcinoma (SCCA).
  • Accepted treatments include any combination of surgery, radiotherapy, and chemotherapy.
  • We review the oncologic and functional outcomes of patients with tonsillar carcinoma who underwent transoral tumor resection and neck dissection with or without postoperative radiotherapy or chemoradiotherapy.
  • METHODS: From 1996 through January 2005, 102 patients with tonsillar SCCA underwent transoral resection.
  • Immediate and long-term speech and swallowing function and treatment-related morbidity were analyzed.
  • CONCLUSIONS: Transoral resection of tonsillar SCCA with or without postoperative adjuvant therapy provided excellent locoregional control and minimized treatment-related morbidity.
  • We believe that transoral resection is the optimal treatment for patients with oropharyngeal SCCA.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tonsillar Neoplasms / surgery. Tonsillectomy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Mouth. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 19235742.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Mendenhall WM, Morris CG, Amdur RJ, Hinerman RW, Malyapa RS, Werning JW, Lansford CD, Villaret DB: Definitive radiotherapy for tonsillar squamous cell carcinoma. Am J Clin Oncol; 2006 Jun;29(3):290-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Definitive radiotherapy for tonsillar squamous cell carcinoma.
  • PURPOSE: The purpose of this study is to update our experience with definitive radiotherapy (RT) for carcinoma of the tonsillar area.
  • Of these, 198 patients underwent a planned neck dissection and 57 patients received induction (18 patients) or concomitant (39 patients) chemotherapy.
  • Local control after RT for early stage cancers was higher for tonsillar fossa/posterior pillar tumors than for those arising from the anterior tonsillar pillar.
  • CONCLUSION: Based on our data and a review of the literature, definitive RT provides cure rates that are as good as those after surgery, and is associated with a lower rate of severe complications.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Incidence. Lymph Node Excision. Male. Middle Aged. Neoplasm Staging. Radiation Injuries / epidemiology. Survival Analysis. Treatment Outcome

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  • (PMID = 16755183.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Xiao W, Yi Z: [Combined therapy of advanced tonsillar squamous cell carcinoma and one-stage repair of the defect]. Zhonghua Er Bi Yan Hou Ke Za Zhi; 2002 Feb;37(1):41-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Combined therapy of advanced tonsillar squamous cell carcinoma and one-stage repair of the defect].
  • OBJECTIVE: To evaluate the treatment of advanced squamous cell carcinoma of the tonsil.
  • METHODS: Eight patients with advanced tonsillar carcinoma underwent resections combining mandibular ramus and oral cavity approaches, neck dissection and one-stage repair of the defect with pectoralis major myocutaneous flap (PM).
  • The managements were supplemented with preoperative chemotherapy and postoperative radiotherapy.
  • One case died of serious hemorrhage resulted from radio-mandibulomyelitis 3 months after operation, and the other case died of esophageal carcinoma 2 years after operation.
  • CONCLUSIONS: Through this combined approach, the advanced tonsillar carcinoma could be resected en bloc under direct visual field and keeping 1-1.5 cm safe margin to the tumor.
  • Neck dissection, preoperative chemotherapy and postoperative radiotherapy were supplemental measures.
  • Combined therapy was of great significance in reducing recurrence of the tumor.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Surgical Flaps. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pectoralis Muscles / surgery

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  • (PMID = 12768794.001).
  • [ISSN] 0412-3948
  • [Journal-full-title] Zhonghua er bi yan hou ke za zhi
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Holsinger FC, McWhorter AJ, Ménard M, Garcia D, Laccourreye O: Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: I. Technique, complications, and functional results. Arch Otolaryngol Head Neck Surg; 2005 Jul;131(7):583-91
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  • [Title] Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: I. Technique, complications, and functional results.
  • PATIENTS: A total of 191 patients who underwent TLO for selected invasive squamous cell carcinoma of the tonsil and/or tonsillar fossa.
  • INTERVENTIONS: Ten patients had received preoperative radiation therapy.
  • Induction chemotherapy was used in 153 patients (80.3%).
  • Postoperative radiation therapy was administered to 52 patients (28.7%).
  • CONCLUSIONS: From a functional standpoint, the TLO is a safe surgical approach for treating selected carcinoma of the tonsillar fossa.
  • It is a reliable technique that should be considered for treatment of appropriate squamous cell carcinoma of the tonsil.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Oropharynx / surgery. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intubation, Gastrointestinal. Length of Stay. Male. Middle Aged. Otorhinolaryngologic Surgical Procedures / methods. Postoperative Complications. Retrospective Studies. Tracheostomy. Treatment Outcome

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  • (PMID = 16027280.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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14. Huguet F, Gratacap M, Ménard J, Perie S, Angelard B, Jafari A, Pène F, Torti F, Touboul E, Lacau St Guily J: Alternative therapeutic approaches after induction chemotherapy for tonsil squamous cell carcinomas. J Clin Oncol; 2009 May 20;27(15_suppl):e17010

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alternative therapeutic approaches after induction chemotherapy for tonsil squamous cell carcinomas.
  • : e17010 Background: The role of induction chemotherapy (ICT) in the treatment of head and neck squamous cell carcinomas (SCC) remains controversial.
  • This retrospective study aims to evaluate the outcome of patients with tonsil SCC treated with ICT followed by surgery and/or external beam radiotherapy (EBRT).
  • METHODS: Between 1997 and 2007, 103 patients (pts) with tonsil SCC received an ICT in Tenon Hospital.
  • Most of pts (88%) received cisplatin (25 mg/m2) and 5-fluorouracil (1,000 mg/m2) for 4 days with a mean of 2.5 cycles.
  • After surgery, 69 pts received a dose of 50 to 70 Gy on the primary site depending on pathological findings (Group 1).
  • In the Group 2, 6 pts had a relapse, among them 4 had EBRT in a second time.
  • CONCLUSIONS: Pts with a complete pathological response after ICT who were not irradiated had a non significant increase of the relapse rate with a specific survival identical to the group of irradiated pts.

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  • (PMID = 27961737.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Junquera L, Gallego L, Torre A, Hernando J, Fresno MF: Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Sep;108(3):413-6
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  • [Title] Synchronous oral squamous cell carcinoma and extramedullary plasmacytoma of the tonsil.
  • Extramedullary plasmacytoma (EP) is characterized by a neoplastic proliferation of plasma cells in a soft tissue site and arises particularly in the head and neck region.
  • We report here an unusual case of maxillary sinus EP coexisting with oral squamous cell carcinoma (SCC) in a patient without any identified environmental risk or predisposing factors.
  • The maxillary sinus mass proved to be radioresistant, with distant metastasis of EP in the tonsil and thoracic skin.
  • The patient subsequently received chemotherapy and showed no evidence of recurrence at 6 months' follow-up.
  • To the best of our knowledge, this is the first case reported demonstrating synchronous occurrence of oral SCC and EP arising in oral cavity.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Maxillary Sinus Neoplasms / pathology. Mouth Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Plasmacytoma / pathology. Tonsillar Neoplasms / pathology

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  • (PMID = 19570691.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD19; 0 / Immunoglobulin kappa-Chains; 0 / Syndecan-1; EC 3.1.3.48 / Antigens, CD45; EC 3.2.2.5 / Antigens, CD38
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16. Kühnel S, Kessler M: [Tonsillar squamous cell carcinoma in the dog. A retrospective study of 33 cases]. Tierarztl Prax Ausg K Kleintiere Heimtiere; 2010;38(6):367-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tonsillar squamous cell carcinoma in the dog. A retrospective study of 33 cases].
  • OBJECTIVE: Retrospective evaluation of clinical findings in 33 dogs with tonsillar squamous cell carcinomas.
  • 24 treated patients were grouped into six categories depending on the type of therapy: 1. tonsillectomy and NSAID (Piroxicam or Metacam) (n=10); 2. tonsillectomy, NSAID, and palliative radiation (24-30Gy in 3-5 fractions) (n=4); 3. tonsillectomy, NSAID, palliative radiation, and chemotherapy (5´ Carboplatin 280-300mg/m2 BSA) (n=3); 4.
  • NSAID, palliative radiation, and chemotherapy (n=1); 5.
  • None of the dogs had lung metastasis at the time of diagnosis, as determined by three view chest X-rays.
  • The best survival times (ST) were achieved in groups 2 and 3 with three of seven patients living longer than 1year.
  • Patients without lymph node metastasis had a trend for longer survival times, independent of the type of therapy.
  • CONCLUSION: It could be confirmed that tonsillar squamous cell carcinomas are aggressive tumours with a high rate of cervical lymph node metastasis.
  • In most cases with metastasis the survival times were relatively short, irrespective of treatment.
  • In early stages of the disease however, good survival times could be achieved using surgical debulking followed by multimodality treatment.
  • CLINICAL RELEVANCE: In squamous cell carcinoma of the tonsils thorough staging is mandatory due to the high metastatic potential of the tumour.
  • Further studies are required to find the best treatment (combination) for these patients.

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  • (PMID = 22212749.001).
  • [ISSN] 1434-1239
  • [Journal-full-title] Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
  • [ISO-abbreviation] Tierarztl Prax Ausg K Kleintiere Heimtiere
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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17. Shirazi HA, Sivanandan R, Goode R, Fee WE, Kaplan MJ, Pinto HA, Goffinet DR, Le QT: Advanced-staged tonsillar squamous carcinoma: organ preservation versus surgical management of the primary site. Head Neck; 2006 Jul;28(7):587-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Advanced-staged tonsillar squamous carcinoma: organ preservation versus surgical management of the primary site.
  • BACKGROUND: Our aim was to review our experience in the management of advanced tonsillar squamous cell carcinoma (SCC) and to compare treatment outcomes between patients treated with and without surgery to the primary site.
  • METHODS: The records of 74 patients with advanced-stage tonsillar SCC were reviewed.
  • Thirty-eight patients received definitive surgery to the primary site, and 36 were treated with an organ-preservation approach (OP) using radiotherapy +/- chemotherapy.
  • RESULTS: No significant difference in overall survival (OS) or freedom from relapse (FFR) by treatment was found.
  • On the basis of these results, we favor organ-preservation therapy for patients with advanced-stage tonsillar SCC.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright 2006 Wiley Periodicals, Inc.
  • (PMID = 16475199.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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18. Mendenhall WM, Amdur RJ, Stringer SP, Villaret DB, Cassisi NJ: Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery? J Clin Oncol; 2000 Jun;18(11):2219-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery?
  • PURPOSE: There are no definitive randomized studies that compare radiotherapy (RT) with surgery for tonsillar cancer.
  • The purpose of this study was to evaluate the results of RT alone and RT combined with a planned neck dissection for carcinoma of the tonsillar area and to compare these data with the results of treatment with primary surgery.
  • One hundred forty-one patients underwent planned neck dissection, and 18 patients received induction (17 patients) or concomitant (one patient) chemotherapy.
  • Local control after RT for early-stage cancers was higher for tonsillar fossa/posterior pillar cancers than for those arising from the anterior tonsillar pillar.
  • The incidence of severe late complications after treatment was 5%.
  • CONCLUSION: RT alone or combined with a planned neck dissection provides cure rates that are as good as those after surgery and is associated with a lower rate of severe complications.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Tonsillar Neoplasms / radiotherapy. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Neck Dissection. Neoplasm Metastasis. Neoplasm Recurrence, Local. Radiotherapy Dosage. Salvage Therapy. Survival Analysis. Treatment Outcome

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  • (PMID = 10829041.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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19. Rusthoven KE, Raben D, Schneider C, Witt R, Sammons S, Raben A: Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach. Int J Radiat Oncol Biol Phys; 2009 Aug 1;74(5):1365-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach.
  • PURPOSE: To review the outcomes of a prospective management approach using ipsilateral neck radiotherapy in the treatment of node-positive squamous cell carcinoma of the tonsil with a well-lateralized primary lesion.
  • METHODS AND MATERIALS: Between August 2003 and June 2007, 20 patients who presented with squamous cell carcinoma of the tonsil, without involvement of the base of the tongue or midline soft palate, and with Stage N1-N2b disease were prospectively treated with radiotherapy to the primary site and ipsilateral neck.
  • In addition, 18 patients received concurrent chemotherapy.
  • Acute and late toxicity were prospectively evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3, and Radiation Therapy Oncology Group criteria.
  • Late Radiation Therapy Oncology Group grade 2 xerostomia occurred in 1 patient (5%).
  • CONCLUSION: In carefully selected patients with node-positive, lateralized tonsillar cancer, treatment of the ipsilateral neck and primary site does not appear to increase the risk of contralateral nodal failure and reduces late morbidity compared with historical controls.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy / methods. Disease-Free Survival. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / radiotherapy. Male. Middle Aged. Neck. Neoplasm Staging. Prospective Studies. Radiotherapy Dosage. Radiotherapy, Conformal / methods. Survival Rate. Treatment Outcome

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  • (PMID = 19168295.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Yildirim G, Morrison WH, Rosenthal DI, Sturgis EM, Papadimitrakopoulou VA, Schwartz DL, Garden AS: Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy. Head Neck; 2010 Apr;32(4):473-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy.
  • BACKGROUND: Our aim was to evaluate the therapeutic outcomes of patients with squamous cell carcinoma of the tonsil that underwent tonsillectomies followed by radiotherapy.
  • Anderson Cancer Center identified 120 patients with carcinoma of the tonsil who were irradiated between 1979 and 2004 following total gross removal of their disease by tonsillectomy.
  • Only 12 patients received systemic chemotherapy.
  • Our common practice is to deliver 66 Gy to the tonsillar bed.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / therapy. Neoplasm Recurrence, Local / pathology. Tonsillar Neoplasms / mortality. Tonsillar Neoplasms / therapy
  • [MeSH-minor] Adult. Age Factors. Aged. Analysis of Variance. Biopsy, Needle. Chemotherapy, Adjuvant. Chi-Square Distribution. Cohort Studies. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Probability. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Sex Factors. Survival Analysis. Tonsillectomy / methods. Treatment Outcome. Young Adult

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  • (PMID = 19691110.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-06294
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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21. Douglas JG, Koh W, Laramore GE: Metastasis to a percutaneous gastrostomy site from head and neck cancer: radiobiologic considerations. Head Neck; 2000 Dec;22(8):826-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The use of percutaneously placed feeding tubes has increased in recent years in an effort to maintain adequate caloric balance in patients receiving combined therapy for head and neck cancers, particularly concurrent radiotherapy and chemotherapy.
  • METHODS: We report a case of a metastasis to a percutaneous endoscopic gastrostomy site occurring in a patient with an advanced tonsillar squamous cell carcinoma and review the published literature regarding this subject.
  • The interval from performance of the procedure to development of the metastases ranged from 3 to 16 months.
  • Tumor kinetics suggest that a significant tumor burden (10(5)-10(6) cells) would need to be present at the site to manifest a metastatic lesion in such a short time interval.
  • Direct tumor implantation by means of instrumentation at the time of the procedure is most likely explanation for such metastases, although hematogenous seeding cannot be completely discounted.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Catheters, Indwelling / adverse effects. Gastrostomy / adverse effects. Neoplasm Seeding. Pharyngeal Neoplasms / pathology. Skin Neoplasms / secondary

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  • [CommentIn] Head Neck. 2001 Dec;23(12):1080-3 [11774395.001]
  • (PMID = 11084645.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] UNITED STATES
  • [Number-of-references] 18
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22. Galati LT, Myers EN, Johnson JT: Primary surgery as treatment for early squamous cell carcinoma of the tonsil. Head Neck; 2000 May;22(3):294-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary surgery as treatment for early squamous cell carcinoma of the tonsil.
  • BACKGROUND: The management of tonsil carcinoma has gradually evolved such that the literature is replete with outcome summaries of this disease treated with primary RT and chemotherapy.
  • Recently there have been no reports of patient outcomes with primary surgical therapy.
  • Nonsurgical treatment is warranted when tumors are unresectable or if the patient refuses surgery.
  • Our policy has been to treat operable squamous cell carcinoma (SCCA) of the tonsil with surgery.
  • The decision to use adjuvant therapy is based on the surgical and histologic findings.
  • We herein report our results with this treatment protocol.
  • METHODS: A retrospective review of 162 patients with SCCA of the tonsil was performed.
  • Eighty-four patients were treated with surgery, which was followed by RT and/or chemotherapy if histologic signs of aggressive behavior were identified.
  • Patients were followed 2 to 15 years after treatment.
  • RESULTS: Of the 9 patients with stage I disease, 89% are without evidence of recurrent disease and 91% of patients with stage II tonsil cancers are also disease free.
  • CONCLUSION: Our data suggest that patients with early tonsil cancer can be effectively treated with surgery.
  • Surgery allows pathologic staging so that patients with advanced tumors can be treated with adjuvant therapy.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / surgery. Tonsillar Neoplasms / mortality. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 10748454.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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23. Maurizio SJ, Eckart AL: A case study associated with oropharyngeal cancer. J Dent Hyg; 2010;84(4):170-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Squamous cell carcinoma (SCC) is the most common oral malignancy, commonly located on the anterior floor of the mouth, lateral borders of the tongue, tonsillar pillars and lateral soft palate.
  • A 59 year old male presented to a Midwestern university dental hygiene clinic following referral for pre-radiation and chemotherapy oral prophylaxis and comprehensive examination.
  • Biopsy confirmed the diagnosis of SCC of the left tonsil.
  • Surgery, radiation and chemotherapy were performed.
  • Dental hygienists should document significant findings and notify the dentist of abnormalities and the need for subsequent referral, providing early detection results in improved prognosis for those who encounter experiences with oral, head and neck cancer.

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  • (PMID = 21047462.001).
  • [ISSN] 1553-0205
  • [Journal-full-title] Journal of dental hygiene : JDH
  • [ISO-abbreviation] J Dent Hyg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Charbonneau N, Gélinas M, del Vecchio P, Guertin L, Larochelle D, Tabet JC, Soulières D, Charpentier D, Nguyen-Tân PF: Primary radiotherapy for tonsillar carcinoma: a good alternative to a surgical approach. J Otolaryngol; 2006 Aug;35(4):227-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary radiotherapy for tonsillar carcinoma: a good alternative to a surgical approach.
  • OBJECTIVES: To review the Notre-Dame hospital experience in the treatment of tonsillar carcinoma with primary radiotherapy and to evaluate the different factors affecting locoregional control (LRC) and survival.
  • METHODS: We reviewed the records of 164 patients treated consecutively for squamous cell carcinoma of the tonsillar region between January 1990 and June 1999.
  • All patients received curative radiotherapy, and 31 patients received chemotherapy either prior to or during treatment with radiotherapy.
  • No patient received surgery as a primary treatment modality.
  • Our results compare favourably with other single-institution surgical series and justify the role of radiotherapy as a primary treatment modality in early tonsillar carcinoma.
  • Concurrent chemotherapy and radiation therapy is currently our standard of care in advanced tonsillar carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Proportional Hazards Models. Survival Rate. Treatment Outcome

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  • (PMID = 17176797.001).
  • [ISSN] 0381-6605
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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25. Aaron S, Wong E, Tyrrell D, Duggan M, Vallieres E, Jewell L, Romanowski B, Doe PJ: Interferon treatment of multiple pulmonary malignancies associated with papilloma virus. Can Respir J; 2004 Sep;11(6):443-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interferon treatment of multiple pulmonary malignancies associated with papilloma virus.
  • Over a period of four years, beginning in spring 1988, a previously healthy man developed a primary squamous cell carcinoma of the tonsil, treated with radiotherapy, followed by 10 distinct, primary bronchial squamous cell carcinomas.
  • Four of the cancers were surgically resected, all of which were positive by hybridization for human papilloma virus (type 16).
  • The finding of papilloma virus in malignancies should prompt consideration of antiviral therapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Antiviral Agents / therapeutic use. Bronchial Neoplasms / virology. Carcinoma, Squamous Cell / virology. Interferon-alpha / therapeutic use. Papillomaviridae. Tonsillar Neoplasms / virology
  • [MeSH-minor] Adult. Humans. Lung / pathology. Male. Palatine Tonsil / pathology. Papillomavirus Infections / complications. Papillomavirus Infections / drug therapy. Treatment Outcome

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  • (PMID = 15510252.001).
  • [ISSN] 1198-2241
  • [Journal-full-title] Canadian respiratory journal
  • [ISO-abbreviation] Can. Respir. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antiviral Agents; 0 / Interferon-alpha
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26. Buch RS, Geisbüsch R, Kunkel M: [Acral ischemia as a rare paraneoplastic syndrome in the terminal phase of mouth floor carcinoma]. Mund Kiefer Gesichtschir; 2002 Sep;6(5):331-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Acral ischemia as a rare paraneoplastic syndrome in the terminal phase of mouth floor carcinoma].
  • [Transliterated title] Akrale Ischämie als seltene Paraneoplasie in der terminalen Erkrankungsphase eines Mundbodenkarzinoms.
  • BACKGROUND: The term "paraneoplastic syndrome" describes a clinically apparent disease associated with a malignant neoplasm, which is not a direct consequence of invasive tumor growth.
  • Symptoms evolved under palliative chemotherapy with gemcitabine for inoperable metachronous squamous cell carcinoma of the tonsil following a history of two simultaneous carcinomas of the alveolar crest.
  • Digital ischemia was combined with severe pain, similar to Raynaud's syndrome, which required therapeutic intervention.
  • The treatment objective is to improve perfusion and simultaneously reduce pain.
  • [MeSH-major] Alveolar Process. Carcinoma, Squamous Cell / diagnosis. Fingers / blood supply. Ischemia / etiology. Maxillary Neoplasms / diagnosis. Mouth Floor. Mouth Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Palliative Care. Paraneoplastic Syndromes / etiology. Tonsillar Neoplasms / diagnosis
  • [MeSH-minor] Aged. Combined Modality Therapy. Humans. Male. Necrosis. Raynaud Disease / therapy. Sympathectomy. Vasodilator Agents / administration & dosage

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  • (PMID = 12448236.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Vasodilator Agents
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