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1. Prestwich RJ, Kancherla K, Oksuz DC, Williamson D, Dyker KE, Coyle C, Sen M: A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage IV tonsillar cancer. Radiat Oncol; 2010;5:121

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage IV tonsillar cancer.
  • BACKGROUND: Chemo-radiotherapy offers an alternative to primary surgery and adjuvant therapy for the management of locally advanced stage IV squamous cell carcinomas of the tonsil.
  • METHODS: A retrospective analysis was performed of the outcomes of 41 patients with locoregionally advanced squamous cell carcinoma of the tonsil treated non-surgically at the Yorkshire Cancer Centre between January 2004 and December 2005.
  • Due to long radiotherapy waiting times, patients received induction chemotherapy with cisplatin and 5-fluorouracil followed by either cisplatin concurrent chemoradiotherapy or radiotherapy alone.
  • 35/41 patients (85%) received 2 or more cycles of induction chemotherapy.
  • Following induction chemotherapy, 32/41 patients (78%) had a clinical response.
  • Concomitant chemotherapy was given to 30/41 (73%).
  • There were no treatment related deaths.
  • Six (15%) patients had gastrostomy tubes placed before treatment, and 22 (54%) required nasogastric tube placement during or after treatment for nutritional support.
  • 17 patients required unplanned admissions during treatment for supportive care.
  • At 4 months post treatment assessment 35 out of 41 (85%) patients achieved complete clinical and radiographic response.
  • CONCLUSION: Cisplatin-based induction and concurrent chemoradiotherapy provides excellent tumour control with acceptable toxicity for patients with locally advanced tonsillar cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Tonsillar Neoplasms / drug therapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant / methods. Combined Modality Therapy. Disease Progression. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant / methods. Retrospective Studies. Survival Analysis

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  • (PMID = 21176154.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3022575
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2. Sheng LM, Zhang LZ, Xu HM, Zhu Y: Ascending colon adenocarcinoma with tonsillar metastasis: a case report and review of the literature. World J Gastroenterol; 2008 Dec 14;14(46):7138-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ascending colon adenocarcinoma with tonsillar metastasis: a case report and review of the literature.
  • Metastatic palatine tonsil cancer is extremely rare, with nearly 100 such tumors reported in the English literature.
  • The prognosis of metastatic palatine tonsil cancer is poor.
  • A 53-year-old man presented with painless left palatine tonsillar swelling and a cervical mass following right hemicolectomy for an ascending colon adenocarcinoma.
  • Physical examination showed an ulcerated mass located on the upper pole of the left palatine tonsil.
  • The patient was treated with palliative radiotherapy and chemotherapy.
  • Our case shows that immunohistochemical diagnosis of metastatic palatine tonsil cancer is essential.
  • [MeSH-major] Adenocarcinoma / pathology. Colon, Ascending / pathology. Colonic Neoplasms / pathology. Tonsillar Neoplasms / diagnosis. Tonsillar Neoplasms / secondary
  • [MeSH-minor] Biopsy. Combined Modality Therapy. Drug Therapy. Humans. Male. Middle Aged. Prognosis. Radiotherapy

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  • (PMID = 19084924.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 23
  • [Other-IDs] NLM/ PMC2776847
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3. Dreilich M, Bergqvist M, Moberg M, Brattström D, Gustavsson I, Bergström S, Wanders A, Hesselius P, Wagenius G, Gyllensten U: High-risk human papilloma virus (HPV) and survival in patients with esophageal carcinoma: a pilot study. BMC Cancer; 2006;6:94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-risk human papilloma virus (HPV) and survival in patients with esophageal carcinoma: a pilot study.
  • BACKGROUND: Human papilloma virus (HPV) in patients with esophageal carcinoma has previously been studied with an average detection rate of 15%, but the role of HPV in relation to survival is less clear.
  • In cervical cancer, lung cancer and tonsil cancer HPV viral load is a predictive factor for survival and outcome of treatment.
  • The primary aim was to study the spectrum of high-risk HPV types in esophageal tumors.
  • METHODS: We compared both the presence and the viral load of high-risk HPV types 16, 18, 31, 33, 39, 45, 52, 58, and 67 in relation to clinical data from patients with esophageal carcinoma.
  • Survival data and tumor samples were retrieved from 100 patients receiving treatment at the Department of Oncology, Uppsala Hospital, Uppsala, Sweden.
  • The tumor samples were investigated for HPV viral load using real-time PCR.
  • RESULTS: HPV 16 was detected in 16% of the patients; no other HPV type was detected.
  • Also, HPV 16 did not improve survival after treatment (radiotherapy or chemotherapy).
  • HPV 16 in esophageal carcinoma patients did not influence survival or improve therapy response.
  • However, given the size of the study there is a need to examine a larger cohort in order to understand in more detail the effect of high risk HPV types in esophageal carcinoma.
  • [MeSH-major] Carcinoma / virology. Esophageal Neoplasms / virology. Human papillomavirus 16. Papillomavirus Infections / complications

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  • (PMID = 16620378.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Other-IDs] NLM/ PMC1475606
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4. Chang AR, Wu HG, Park CI, Kim KH, Sung MW, Heo DS: Retrospective analysis of the treatment results for patients with squamous cell carcinoma of tonsil. Cancer Res Treat; 2005 Apr;37(2):92-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrospective analysis of the treatment results for patients with squamous cell carcinoma of tonsil.
  • PURPOSE: There has been no definitive randomized study to identify the optimal therapeutic regimen for treating squamous cell carcinoma of tonsil.
  • The purpose of this study was to retrospectively evaluate the treatment outcome according to various combinations of surgery, radiation therapy and chemotherapy.
  • MATERIALS AND METHODS: Fifty-six patients with tonsillar carcinoma, who were treated at Seoul National University Hospital from March 1985 to August 2001, were the subjects of this study.
  • Twenty-one patients received surgery followed by radiation therapy (SRT), 16 patients underwent radiation therapy alone (RT), and 19 patients received neoadjuvant chemotherapy and radiation therapy (CRT).
  • The median radiation dose was 66.6 Gy for the SRT group and 70.2 Gy for the RT and CRT groups.
  • RESULTS: The distribution of T-stage was 4 cases of T1, 14 cases of T2, 1 case of T3 and 2 cases of T4 staging in the SRT group, 2 cases of T1, 6 cases of T2, 5 cases of T3 and 3 cases of T4 staging in the RT group and 0 cases of T1, 7 cases of T2, 9 cases of T3 and 3 cases of T4 staging in the CRT group.
  • Four patients developed local failure and one patient failed at a regional site in the RT group, and one patient failed at a primary site in the CRT group.
  • Treatment-related complications of grade 3 or 4 occurred in 15 patients, and the incidence of complication was not different between each of the treatment methods.
  • CONCLUSION: Although the patients with more advanced T stage were included in the RT and CRT groups, the OSR was not statistically different according to the treatment methods.
  • In the radical radiation therapy group, the addition of neoadjuvant chemotherapy showed an improvement in the disease-free survival.
  • Because of the retrospective nature of our study and the small number of patients, this study cannot draw any definite conclusions, but it suggests that radiation therapy with chemotherapy can be a good alternative option for squamous cell carcinoma of tonsil.

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  • (PMID = 19956486.001).
  • [ISSN] 2005-9256
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2785396
  • [Keywords] NOTNLM ; Chemotherapy / Radiation therapy / Squamous cell carcinoma of tonsil / Surgery
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5. Nieder C, Steen RE, Dalhaug A: A Challenging Picture of Cancer-and Inflammation-Related Changes. Clin Med Oncol; 2009;3:15-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Challenging Picture of Cancer-and Inflammation-Related Changes.
  • The authors describe a diagnostically challenging case where a patient with previous squamous cell carcinoma of the tonsil developed a putative second primary squamous cell carcinoma in the lung (stage IV with lung and bone metastases).
  • During palliative chemotherapy several episodes of severe infection occurred, eventually resulting in abscess formation in the hip and brain.
  • The dilemma of distinguishing between metastasis and abscess and the therapeutic implications are discussed.

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  • (PMID = 20689606.001).
  • [ISSN] 1177-9314
  • [Journal-full-title] Clinical medicine. Oncology
  • [ISO-abbreviation] Clin Med Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2872603
  • [Keywords] NOTNLM ; abscess / brain metastases / head and neck cancer / lung cancer / metastasis
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6. Genden EM, Ferlito A, Scully C, Shaha AR, Higgins K, Rinaldo A: Current management of tonsillar cancer. Oral Oncol; 2003 Jun;39(4):337-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current management of tonsillar cancer.
  • Traditionally, risk factors for the development of tonsil cancer include the use of alcohol and/or tobacco, however a significant proportion of new cases develop in young patients without these risk factors.
  • Irrespective of the etiology, in the majority of cases early carcinoma of the tonsil can effectively be treated using single modality therapy.
  • In contrast to early tonsillar disease, advanced tonsil cancer represents a clinical challenge that requires multimodality therapy.
  • While advanced lesions are often treated with a combination of radiation, chemotherapy, and surgical ablation, management of the neck and distant metastases continues to present a therapeutic dilemma.
  • [MeSH-major] Carcinoma / radiotherapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Combined Modality Therapy. Humans. Lymphatic Metastasis. Neoplasm Staging. Papillomaviridae. Papillomavirus Infections / complications. Radiotherapy Dosage. Treatment Outcome. Tumor Virus Infections / complications

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  • [Copyright] Copyright 2002 Elsevier Science Ltd.
  • (PMID = 12676252.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 49
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7. Naidu SI, Vieira F, Samant S, Vang MC, Wan AY, Robbins TK: Targeted intra-arterial chemoradiation for advanced tonsil cancer. Otolaryngol Head Neck Surg; 2005 Dec;133(6):882-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Targeted intra-arterial chemoradiation for advanced tonsil cancer.
  • OBJECTIVES: To determine the effects of combined radiation and targeted, intra-arterial (IA) cisplatin infusions (RADPLAT) in patients with advanced squamous cell carcinoma (SCC) of the tonsil.
  • STUDY DESIGN AND SETTING: Prospective study of treatment outcomes and toxicity of patients enrolled on the RADPLAT protocol, with specific analysis of patients with advanced SCC of the tonsil.
  • RESULTS: Thirty patients with advanced tonsil carcinoma (17 T(4), 12 T(3), 1 T(2)) were enrolled, and 24 of 30 patients completed at least 3 IA cisplatin infusions and a minimum of 63 Gy or radiation therapy (minimum therapy).
  • Two-year estimated overall and disease-specific survival was 42% and 50%, respectively, for all 30 patients (intent-to-treat group) and 49% and 58%, respectively, for the minimum therapy subgroup.
  • The 2-year estimated local and regional disease control was 87% and 90%, respectively, for the intent-to-treat group, and 100% and 90% for the minimum therapy subgroup.
  • CONCLUSIONS: Locoregional disease control achieved with this regimen appears to be significantly improved over that described in the literature for similarly staged tonsil cancer.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Cisplatin / therapeutic use. Tonsillar Neoplasms / drug therapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Biopsy. Female. Follow-Up Studies. Humans. Infusions, Intra-Arterial. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Radiotherapy, Adjuvant. Survival Rate. Treatment Outcome

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  • (PMID = 16360508.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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8. Rusthoven KE, Raben D, Schneider C, Witt R, Sammons S, Raben A: Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach. Int J Radiat Oncol Biol Phys; 2009 Aug 1;74(5):1365-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Freedom from local and regional failure of contralateral neck with ipsilateral neck radiotherapy for node-positive tonsil cancer: results of a prospective management approach.
  • PURPOSE: To review the outcomes of a prospective management approach using ipsilateral neck radiotherapy in the treatment of node-positive squamous cell carcinoma of the tonsil with a well-lateralized primary lesion.
  • METHODS AND MATERIALS: Between August 2003 and June 2007, 20 patients who presented with squamous cell carcinoma of the tonsil, without involvement of the base of the tongue or midline soft palate, and with Stage N1-N2b disease were prospectively treated with radiotherapy to the primary site and ipsilateral neck.
  • In addition, 18 patients received concurrent chemotherapy.
  • Acute and late toxicity were prospectively evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3, and Radiation Therapy Oncology Group criteria.
  • Late Radiation Therapy Oncology Group grade 2 xerostomia occurred in 1 patient (5%).
  • CONCLUSION: In carefully selected patients with node-positive, lateralized tonsillar cancer, treatment of the ipsilateral neck and primary site does not appear to increase the risk of contralateral nodal failure and reduces late morbidity compared with historical controls.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy / methods. Disease-Free Survival. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / radiotherapy. Male. Middle Aged. Neck. Neoplasm Staging. Prospective Studies. Radiotherapy Dosage. Radiotherapy, Conformal / methods. Survival Rate. Treatment Outcome

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  • (PMID = 19168295.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Galati LT, Myers EN, Johnson JT: Primary surgery as treatment for early squamous cell carcinoma of the tonsil. Head Neck; 2000 May;22(3):294-6
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  • [Title] Primary surgery as treatment for early squamous cell carcinoma of the tonsil.
  • BACKGROUND: The management of tonsil carcinoma has gradually evolved such that the literature is replete with outcome summaries of this disease treated with primary RT and chemotherapy.
  • Recently there have been no reports of patient outcomes with primary surgical therapy.
  • Nonsurgical treatment is warranted when tumors are unresectable or if the patient refuses surgery.
  • Our policy has been to treat operable squamous cell carcinoma (SCCA) of the tonsil with surgery.
  • The decision to use adjuvant therapy is based on the surgical and histologic findings.
  • We herein report our results with this treatment protocol.
  • METHODS: A retrospective review of 162 patients with SCCA of the tonsil was performed.
  • Eighty-four patients were treated with surgery, which was followed by RT and/or chemotherapy if histologic signs of aggressive behavior were identified.
  • Patients were followed 2 to 15 years after treatment.
  • RESULTS: Of the 9 patients with stage I disease, 89% are without evidence of recurrent disease and 91% of patients with stage II tonsil cancers are also disease free.
  • The survival rates for stage III and stage IV cancer patients are 79 and 52%, respectively.
  • CONCLUSION: Our data suggest that patients with early tonsil cancer can be effectively treated with surgery.
  • Surgery allows pathologic staging so that patients with advanced tumors can be treated with adjuvant therapy.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / surgery. Tonsillar Neoplasms / mortality. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 10748454.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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10. Hofmann U, O'Connor JP, Biyani CS, Harnden P, Selby P, Weston PM: Retroperitoneal metastatic squamous cell carcinoma of the tonsil (with elevated beta human chorionic gonadotrophin): a misdiagnosis as extra-gonadal germ cell tumour. J Laryngol Otol; 2006 Oct;120(10):885-7
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  • [Title] Retroperitoneal metastatic squamous cell carcinoma of the tonsil (with elevated beta human chorionic gonadotrophin): a misdiagnosis as extra-gonadal germ cell tumour.
  • A case of retroperitoneal metastasis from a squamous cell carcinoma of the tonsil, secreting beta human chorionic gonadotrophin (beta-hCG), is reported.
  • A 58-year-old man had undergone a tonsillectomy and chemo-radiotherapy for squamous cell carcinoma of the left tonsil and 13 months later presented with non-specific abdominal pain.
  • A computed tomography scan demonstrated para-aortic retroperitoneal lymphadenopathy.
  • The initial pathological analysis was interpreted as extra-gonadal germ cell tumour and the patient received chemotherapy.
  • A subsequent review was consistent with a metastatic squamous cell carcinoma of the tonsil, as immunohistochemical studies showed positive staining for epithelial membrane antigen and cytokeratins 5/6 but a negative reaction to placental alkaline phosphatase.
  • Following this, the chemotherapy regimen was changed; however, a restaging scan demonstrated progression, and the patient died from aspiration pneumonia secondary to alcohol intoxication.
  • To our knowledge, this is the first reported case of retroperitoneal metastasis from a squamous cell carcinoma of the tonsil, secreting beta-hCG and causing hydronephrosis.
  • This case highlights the necessity of using clinical, histological, immunohistological and ultrastructural examination to establish precise diagnosis and to avoid inappropriate treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Diagnostic Errors. Neoplasms, Germ Cell and Embryonal / diagnosis. Retroperitoneal Neoplasms / diagnosis. Tonsillar Neoplasms
  • [MeSH-minor] Chorionic Gonadotropin, beta Subunit, Human / blood. Fatal Outcome. Humans. Hydronephrosis / complications. Male. Middle Aged. Neoplasm Proteins / blood

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  • (PMID = 16716237.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / Neoplasm Proteins
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11. Yao M, Dornfeld KJ, Buatti JM, Skwarchuk M, Tan H, Nguyen T, Wacha J, Bayouth JE, Funk GF, Smith RB, Graham SM, Chang K, Hoffman HT: Intensity-modulated radiation treatment for head-and-neck squamous cell carcinoma--the University of Iowa experience. Int J Radiat Oncol Biol Phys; 2005 Oct 1;63(2):410-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intensity-modulated radiation treatment for head-and-neck squamous cell carcinoma--the University of Iowa experience.
  • PURPOSE: To review the University of Iowa experience with intensity-modulated radiotherapy (IMRT) in the treatment of head-and-neck squamous cell carcinoma.
  • METHODS AND MATERIALS: From October 1999 to April 2004, 151 patients with head-and-neck squamous cell carcinoma were treated with IMRT for curative intent.
  • One patient was lost to follow-up 2 months after treatment and therefore excluded from analysis.
  • Of the remaining 150 patients, 99 were treated with definitive IMRT, and 51 received postoperative IMRT.
  • None of the patients treated with postoperative IMRT received chemotherapy.
  • Of 99 patients who had definitive IMRT, 68 patients received concurrent cisplatin-based chemotherapy.
  • One patient received induction cisplatin-based chemotherapy, but no concurrent chemotherapy was given.
  • The prescribed doses to CTV1, CTV2, and CTV3 in the definitive cohort were 70-74 Gy, 60 Gy, and 54 Gy, respectively.
  • For high-risk postoperative IMRT, the prescribed doses to CTV1, CTV2, and CTV3 were 64-66 Gy, 60 Gy, and 54 Gy, respectively.
  • For intermediate-risk postoperative IMRT, the prescribed doses to CTV1, CTV2, and CTV3 were 60 Gy, 60 Gy, and 54 Gy.
  • The median time from treatment completion to local-regional recurrence was 4.7 months (range, 1.8 to 15.6 months).
  • Only one marginal failure was noted in a patient who had extensive tonsil cancer with tumor extension into the orbit and cavernous sinus.
  • Patients with oropharyngeal cancer did significantly better than patients with oral cavity and laryngeal cancer, with a 2-year local-regional control rate of 98%, compared with 78% for oral cavity cancer and 85% for laryngeal cancer (p = 0.005).
  • There was no significant difference in local-regional control for patients who received postoperative radiation or definitive radiation (p = 0.339) and for patients who had chemotherapy or not (p = 0.402).
  • CONCLUSIONS: Our results have confirmed the effectiveness of IMRT in head-and-neck cancer.
  • More studies are necessary to further improve the outcomes of laryngeal cancer as well as oral cavity cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Head and Neck Neoplasms / radiotherapy. Radiotherapy, Conformal / methods
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Female. Humans. Iowa. Male. Middle Aged. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Retrospective Studies. Survival Analysis. Tomography, X-Ray Computed. Treatment Failure. Universities

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  • (PMID = 16168834.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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12. Mendenhall WM, Amdur RJ, Stringer SP, Villaret DB, Cassisi NJ: Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery? J Clin Oncol; 2000 Jun;18(11):2219-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation therapy for squamous cell carcinoma of the tonsillar region: a preferred alternative to surgery?
  • PURPOSE: There are no definitive randomized studies that compare radiotherapy (RT) with surgery for tonsillar cancer.
  • The purpose of this study was to evaluate the results of RT alone and RT combined with a planned neck dissection for carcinoma of the tonsillar area and to compare these data with the results of treatment with primary surgery.
  • One hundred forty-one patients underwent planned neck dissection, and 18 patients received induction (17 patients) or concomitant (one patient) chemotherapy.
  • Local control after RT for early-stage cancers was higher for tonsillar fossa/posterior pillar cancers than for those arising from the anterior tonsillar pillar.
  • The incidence of severe late complications after treatment was 5%.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Tonsillar Neoplasms / radiotherapy. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Neck Dissection. Neoplasm Metastasis. Neoplasm Recurrence, Local. Radiotherapy Dosage. Salvage Therapy. Survival Analysis. Treatment Outcome

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  • (PMID = 10829041.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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13. Pajor A, Murlewska A, Józefowicz-Korczyńska M: [Tonsillar carcinoma--clinical assessment and analysis of treatment results]. Otolaryngol Pol; 2002;56(3):319-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tonsillar carcinoma--clinical assessment and analysis of treatment results].
  • The aim of the study was an evaluation of the clinical signs and treatment results of the patients with tonsillar cancer treated in the ENT Clinic Medical University in Łódź during 10 years (1985-1994).
  • The most frequent treatment modality was combined therapy (surgery with radio/chemotherapy) introduced in 25 persons (62.5%), surgery alone was performed in 10 cases (25%).
  • Distant metastases developed in 6 patients (15%) and the second primary neoplasm in 5 patients (12.5%).
  • We stress the importance of careful clinical assessment before planning the treatment.
  • [MeSH-major] Carcinoma, Squamous Cell. Tonsillar Neoplasms
  • [MeSH-minor] Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / surgery. Combined Modality Therapy. Disease-Free Survival. Humans. Radiotherapy, Adjuvant. Retrospective Studies. Salivary Gland Neoplasms / radiotherapy. Salivary Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 12162020.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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14. Marchese-Ragona R, Maria Ferraro S, Marioni G, Staffieri C, Manara R, Restivo DA, Staffieri A: Abducent nerve paralysis: first clinical sign of clivus metastasis from tonsillar carcinoma. Acta Otolaryngol; 2008 Jun;128(6):713-6
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  • [Title] Abducent nerve paralysis: first clinical sign of clivus metastasis from tonsillar carcinoma.
  • It is known that 15-20% of oropharyngeal carcinomas develop distant metastases that involve most commonly lung, liver and bone.
  • Clival metastasis from oropharyngeal squamous cell carcinoma has not been previously reported in the English literature.
  • We describe the rare occurrence of clival metastasis from tonsillar carcinoma presenting with abducent paralysis and discuss diagnostic and therapeutic rational approaches.
  • Despite neoadjuvant chemotherapy (cisplatinum/etoposide/epirubicin followed by taxotere), extended left tonsillectomy and ipsilateral radical neck dissection and external radiotherapy (60 Gy) for tonsillar carcinoma, the patient developed clival metastasis and died of disease.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Carcinoma, Squamous Cell / secondary. Cranial Fossa, Posterior. Skull Base Neoplasms / secondary. Tonsillar Neoplasms / pathology

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  • (PMID = 18568510.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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15. Yildirim G, Morrison WH, Rosenthal DI, Sturgis EM, Papadimitrakopoulou VA, Schwartz DL, Garden AS: Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy. Head Neck; 2010 Apr;32(4):473-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy.
  • BACKGROUND: Our aim was to evaluate the therapeutic outcomes of patients with squamous cell carcinoma of the tonsil that underwent tonsillectomies followed by radiotherapy.
  • Anderson Cancer Center identified 120 patients with carcinoma of the tonsil who were irradiated between 1979 and 2004 following total gross removal of their disease by tonsillectomy.
  • Only 12 patients received systemic chemotherapy.
  • Our common practice is to deliver 66 Gy to the tonsillar bed.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / therapy. Neoplasm Recurrence, Local / pathology. Tonsillar Neoplasms / mortality. Tonsillar Neoplasms / therapy
  • [MeSH-minor] Adult. Age Factors. Aged. Analysis of Variance. Biopsy, Needle. Chemotherapy, Adjuvant. Chi-Square Distribution. Cohort Studies. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Probability. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Sex Factors. Survival Analysis. Tonsillectomy / methods. Treatment Outcome. Young Adult

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  • (PMID = 19691110.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-06294
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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16. Aziz L, Nyman J, Edström S: T but not N stage predicts survival for patients with tonsillar carcinoma treated with external radiotherapy and brachytherapy. Acta Oncol; 2010 Aug;49(6):821-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] T but not N stage predicts survival for patients with tonsillar carcinoma treated with external radiotherapy and brachytherapy.
  • BACKGROUND: Our aim was to determine the efficacy of a therapeutic schedule including external radiation and brachytherapy in a consecutive and retrospective series of tonsillar carcinoma patients.
  • PATIENTS AND METHODS: Ninety-six patients with tonsillar carcinoma were treated between 1988 and 2000 and were followed up for at least for three years.
  • All patients were treated with accelerated hyperfractionated external radiotherapy, 68 patients had additional brachytherapy and 69 patients with advanced stages also received chemotherapy.
  • OS for the T stage was T1 90%, T2 89%, T3 54% and T4 60%.
  • Accordingly OS was influenced by the T stage (p>0.001) rather than by N stage.
  • DISCUSSION: The primary tumour stage is an essential determinant for survival in patients with irradiated tonsillar carcinoma.
  • Neck dissection should be confined only as a salvage procedure.
  • [MeSH-major] Brachytherapy. Carcinoma / mortality. Carcinoma / pathology. Tonsillar Neoplasms / mortality. Tonsillar Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Dose Fractionation. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neck Dissection. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Predictive Value of Tests. Retrospective Studies. Salvage Therapy / methods

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  • (PMID = 20615169.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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17. Charbonneau N, Gélinas M, del Vecchio P, Guertin L, Larochelle D, Tabet JC, Soulières D, Charpentier D, Nguyen-Tân PF: Primary radiotherapy for tonsillar carcinoma: a good alternative to a surgical approach. J Otolaryngol; 2006 Aug;35(4):227-34

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary radiotherapy for tonsillar carcinoma: a good alternative to a surgical approach.
  • OBJECTIVES: To review the Notre-Dame hospital experience in the treatment of tonsillar carcinoma with primary radiotherapy and to evaluate the different factors affecting locoregional control (LRC) and survival.
  • METHODS: We reviewed the records of 164 patients treated consecutively for squamous cell carcinoma of the tonsillar region between January 1990 and June 1999.
  • All patients received curative radiotherapy, and 31 patients received chemotherapy either prior to or during treatment with radiotherapy.
  • No patient received surgery as a primary treatment modality.
  • Our results compare favourably with other single-institution surgical series and justify the role of radiotherapy as a primary treatment modality in early tonsillar carcinoma.
  • Concurrent chemotherapy and radiation therapy is currently our standard of care in advanced tonsillar carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Tonsillar Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Proportional Hazards Models. Survival Rate. Treatment Outcome

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  • (PMID = 17176797.001).
  • [ISSN] 0381-6605
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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18. Syed MI, Clark LJ, Sturrock RD: Unintended benefits of immunosupression on autoimmune disease due to chemoradiation therapy for head and neck cancer. Am J Otolaryngol; 2008 Jan-Feb;29(1):63-5
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  • [Title] Unintended benefits of immunosupression on autoimmune disease due to chemoradiation therapy for head and neck cancer.
  • The immune system is an important factor in the host's defenses against cancer.
  • Immunosupression by radiation and/or chemotherapy is often associated with systemic and hematologic complications, opportunistic infections, and the development of malignancies, but immunosupression can also have beneficial effects, which are sometimes incidental.
  • The first case is about a patient with carcinoma of the tonsil, with severe rheumatoid arthritis, who was treated with chemoradiation, which resulted in remission of his arthritis.
  • The second case is about a patient with severe atopic eczema who was on long-term treatment with psoralen and ultraviolet A radiation and azathioprine; the patient developed metastatic carcinoma of the lip, which was treated with surgery and radiation that resulted in complete remission of his eczema.
  • [MeSH-minor] Aged. Follow-Up Studies. Humans. Immunosuppressive Agents / therapeutic use. Male. Middle Aged. Remission Induction / methods

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  • (PMID = 18061835.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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19. Nguyen NP, Frank C, Moltz CC, Vos P, Smith HJ, Nguyen PD, Martinez T, Karlsson U, Dutta S, Lemanski C, Nguyen LM, Sallah S: Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer. Br J Radiol; 2009 Aug;82(980):675-80
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  • [Title] Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer.
  • Our aim was to identify risk factors for aspiration following concurrent chemoradiation for oropharyngeal cancer.
  • 46 patients with locally advanced oropharyngeal carcinoma underwent concurrent chemoradiation at our institution.
  • All patients underwent modified barium swallow to assess dysphagia severity and to determine the need for continued tube feedings after treatment.
  • 25 patients (54%) developed aspiration (5 trace, 20 severe).
  • There was no statistical difference in the aspiration rate between the base of the tongue and tonsillar carcinoma (p = 0.23).
  • Despite anatomical organ preservation, most patients with locally advanced oropharyngeal carcinoma had moderate to severe dysphagia after chemoradiation.
  • Patients with large tumours had a significant risk of developing aspiration following treatment.
  • [MeSH-major] Deglutition Disorders / etiology. Oropharyngeal Neoplasms / drug therapy. Oropharyngeal Neoplasms / radiotherapy. Respiratory Aspiration / etiology
  • [MeSH-minor] Aged. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Barium Sulfate / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy / adverse effects. Contrast Media / administration & dosage. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Radiation-Sensitizing Agents / administration & dosage. Retrospective Studies. Risk Factors. Texas. Tongue Neoplasms / complications. Tongue Neoplasms / drug therapy. Tongue Neoplasms / radiotherapy. Tonsillar Neoplasms / complications. Tonsillar Neoplasms / drug therapy. Tonsillar Neoplasms / radiotherapy. Treatment Outcome

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  • (PMID = 19332514.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Contrast Media; 0 / Radiation-Sensitizing Agents; 25BB7EKE2E / Barium Sulfate; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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20. Laccourreye O, Hans S, Ménard M, Garcia D, Brasnu D, Holsinger FC: Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: II. An analysis of the incidence, related variables, and consequences of local recurrence. Arch Otolaryngol Head Neck Surg; 2005 Jul;131(7):592-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: II. An analysis of the incidence, related variables, and consequences of local recurrence.
  • PATIENTS: A total of 166 previously untreated patients with squamous cell carcinoma of the tonsil.
  • INTERVENTIONS: A total of 131 (81.9%) of the 166 patients received preoperative induction chemotherapy.
  • Fifty-one patients (30.7%) underwent postoperative radiation therapy.
  • In univariate analysis, 7 variables were significantly associated with an increased risk of local failure: increasing T classification; positive margins of resection; poor clinical response to induction chemotherapy; tumor spread to the posterior pillar, posterior pharyngeal wall, and contralateral soft palate; and invasion of the junction between the tonsil and soft palate.
  • CONCLUSIONS: Selected tonsillar squamous cell carcinoma can be managed with TLO with local control comparable to radiotherapy.
  • Patient selection is critical and TLO is best suited for patients with anterior T1 to T2 squamous cell carcinoma of the tonsil, without posterior anatomic spread.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neoplasm Recurrence, Local. Oropharynx / surgery. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Logistic Models. Male. Middle Aged. Neoplasm Metastasis. Neoplasms, Second Primary. Otorhinolaryngologic Surgical Procedures / methods

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  • (PMID = 16027281.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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21. Nguyen NP, Vos P, Smith HJ, Nguyen PD, Alfieri A, Karlsson U, Dutta S, Lemanski C, Nguyen LM, Sallah S: Concurrent chemoradiation for locally advanced oropharyngeal cancer. Am J Otolaryngol; 2007 Jan-Feb;28(1):3-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concurrent chemoradiation for locally advanced oropharyngeal cancer.
  • PURPOSE: The aim of this study was to assess the survival, pattern of failure, morbidity, and prognostic factors of concurrent chemoradiation for locally advanced oropharyngeal cancer.
  • MATERIALS AND METHODS: A retrospective survey of patients who underwent chemotherapy and radiation for locally advanced oropharyngeal carcinoma at the Veteran Affairs North Texas Health Care System, Dallas, Tex.
  • RESULTS: Between December 1999 and September 2004, 48 patients with locally advanced oropharyngeal cancer underwent concurrent chemotherapy and radiation.
  • Seventeen patients (35%) developed recurrences.
  • Distant metastases developed in 8 patients (5 alone, 3 associated with locoregional failures).
  • Four patients (8%) developed second primaries.
  • No difference was observed in survival between base of tongue and tonsillar carcinoma (P = .32).
  • No patient with T1-T2 tumors developed distant metastases (P = .04).
  • Forty-five patients (94%) developed toxicity grade 3 to 4 (40 mucositis and 26 hematological).
  • Eight patients (16%) developed aspiration pneumonia during and after treatment.
  • Five patients (10%) died of aspiration (2 during and 3 post treatment).
  • Four patients (8%) developed esophageal strictures requiring repeated dilatations post treatment.
  • Two patients had radionecrosis (1 soft tissue and 1 bone) requiring hyperbaric oxygen.
  • Eighteen patients (37%) had prolonged tube feedings (>3 months) after treatments because of severe dysphagia or aspiration.
  • CONCLUSION: Concurrent chemoradiation provided good locoregional control for locally advanced oropharyngeal carcinoma.
  • [MeSH-major] Oropharyngeal Neoplasms / drug therapy. Oropharyngeal Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Antimetabolites, Antineoplastic / therapeutic use. Combined Modality Therapy. Fluorouracil / therapeutic use. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Radiotherapy Dosage. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17162122.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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22. Holsinger FC, McWhorter AJ, Ménard M, Garcia D, Laccourreye O: Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: I. Technique, complications, and functional results. Arch Otolaryngol Head Neck Surg; 2005 Jul;131(7):583-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: I. Technique, complications, and functional results.
  • PATIENTS: A total of 191 patients who underwent TLO for selected invasive squamous cell carcinoma of the tonsil and/or tonsillar fossa.
  • INTERVENTIONS: Ten patients had received preoperative radiation therapy.
  • Induction chemotherapy was used in 153 patients (80.3%).
  • Postoperative radiation therapy was administered to 52 patients (28.7%).
  • In this series, the internal carotid artery was never injured, and no cutaneous-oropharyngeal fistulas were apparent.
  • CONCLUSIONS: From a functional standpoint, the TLO is a safe surgical approach for treating selected carcinoma of the tonsillar fossa.
  • It is a reliable technique that should be considered for treatment of appropriate squamous cell carcinoma of the tonsil.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Oropharynx / surgery. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Intubation, Gastrointestinal. Length of Stay. Male. Middle Aged. Otorhinolaryngologic Surgical Procedures / methods. Postoperative Complications. Retrospective Studies. Tracheostomy. Treatment Outcome

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  • (PMID = 16027280.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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23. Wang X, Xie FY, Han F, Hu WH, Li JS, Xu HM: [Tonsillar carcinoma: analyses of the therapy and prognostic factors]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Oct;44(10):848-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tonsillar carcinoma: analyses of the therapy and prognostic factors].
  • OBJECTIVE: To retrospectively analyze the therapeutic effect on patients with tonsillar carcinoma and factors affecting their prognosis.
  • METHODS: Clinical data of 61 patients pathologically confirmed with tonsillar carcinoma without distant metastasis were analyzed.
  • All the patients were treated in Cancer Center of Sun Yat-sen University from April 1997 to April 2008.
  • There were 2 patients with undifferentiated carcinoma, 26 with poorly differentiated squamous cell carcinoma and 33 with median-well differentiated squamous cell carcinoma.
  • The treatment was radiotherapy alone in 27 cases, radiotherapy combined with chemotherapy in 23 cases, surgery combined with postoperative radiotherapy in 6 cases, neoadjuvant chemotherapy plus surgery combined with postoperative radiotherapy in 3 cases, radiotherapy with salvage surgery in 2 cases.
  • The difference between the two treatments was not significant in statistics (P = 0.318).
  • For III-IV staged 45 cases, there were 19 cases with simple radiotherapy, 5 years survival was 51.5%, 21 cases with radiotherapy combined with chemotherapy, 5 years survival was 36.4%, 5 cases with surgery combined with postoperative radiotherapy, 5 years survival was 75.0%.
  • The difference among the three treatments was not significant in statistics (P = 0.239).
  • Multivariate analysis demonstrated that T stage, therapeutic effect of primary site and cervical metastatic lymph node were the independent prognostic factors (P < 0.05).
  • CONCLUSIONS: T stage, the therapeutic effect of primary site and cervical metastatic lymph node were the independent prognostic factors.
  • For I-II staged tonsillar tumor cases, based on organ preservation, were tendency to choice simple radiotherapy.
  • For III-IV staged cases, yet the relationships between therapeutic mode and therapeutic effect still need further researches.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Tonsillar Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 20079056.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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24. Buch RS, Geisbüsch R, Kunkel M: [Acral ischemia as a rare paraneoplastic syndrome in the terminal phase of mouth floor carcinoma]. Mund Kiefer Gesichtschir; 2002 Sep;6(5):331-5
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  • [Title] [Acral ischemia as a rare paraneoplastic syndrome in the terminal phase of mouth floor carcinoma].
  • [Transliterated title] Akrale Ischämie als seltene Paraneoplasie in der terminalen Erkrankungsphase eines Mundbodenkarzinoms.
  • BACKGROUND: The term "paraneoplastic syndrome" describes a clinically apparent disease associated with a malignant neoplasm, which is not a direct consequence of invasive tumor growth.
  • Symptoms evolved under palliative chemotherapy with gemcitabine for inoperable metachronous squamous cell carcinoma of the tonsil following a history of two simultaneous carcinomas of the alveolar crest.
  • Digital ischemia was combined with severe pain, similar to Raynaud's syndrome, which required therapeutic intervention.
  • The treatment objective is to improve perfusion and simultaneously reduce pain.
  • [MeSH-major] Alveolar Process. Carcinoma, Squamous Cell / diagnosis. Fingers / blood supply. Ischemia / etiology. Maxillary Neoplasms / diagnosis. Mouth Floor. Mouth Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Palliative Care. Paraneoplastic Syndromes / etiology. Tonsillar Neoplasms / diagnosis
  • [MeSH-minor] Aged. Combined Modality Therapy. Humans. Male. Necrosis. Raynaud Disease / therapy. Sympathectomy. Vasodilator Agents / administration & dosage

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  • (PMID = 12448236.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Vasodilator Agents
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25. Moore EJ, Henstrom DK, Olsen KD, Kasperbauer JL, McGree ME: Transoral resection of tonsillar squamous cell carcinoma. Laryngoscope; 2009 Mar;119(3):508-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transoral resection of tonsillar squamous cell carcinoma.
  • OBJECTIVES: The tonsillar fossa is the most common subsite of the oropharynx to be afflicted with squamous cell carcinoma (SCCA).
  • Accepted treatments include any combination of surgery, radiotherapy, and chemotherapy.
  • We review the oncologic and functional outcomes of patients with tonsillar carcinoma who underwent transoral tumor resection and neck dissection with or without postoperative radiotherapy or chemoradiotherapy.
  • METHODS: From 1996 through January 2005, 102 patients with tonsillar SCCA underwent transoral resection.
  • Immediate and long-term speech and swallowing function and treatment-related morbidity were analyzed.
  • CONCLUSIONS: Transoral resection of tonsillar SCCA with or without postoperative adjuvant therapy provided excellent locoregional control and minimized treatment-related morbidity.
  • We believe that transoral resection is the optimal treatment for patients with oropharyngeal SCCA.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Tonsillar Neoplasms / surgery. Tonsillectomy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Mouth. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 19235742.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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26. Xiao W, Yi Z: [Combined therapy of advanced tonsillar squamous cell carcinoma and one-stage repair of the defect]. Zhonghua Er Bi Yan Hou Ke Za Zhi; 2002 Feb;37(1):41-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Combined therapy of advanced tonsillar squamous cell carcinoma and one-stage repair of the defect].
  • OBJECTIVE: To evaluate the treatment of advanced squamous cell carcinoma of the tonsil.
  • METHODS: Eight patients with advanced tonsillar carcinoma underwent resections combining mandibular ramus and oral cavity approaches, neck dissection and one-stage repair of the defect with pectoralis major myocutaneous flap (PM).
  • The managements were supplemented with preoperative chemotherapy and postoperative radiotherapy.
  • One case died of serious hemorrhage resulted from radio-mandibulomyelitis 3 months after operation, and the other case died of esophageal carcinoma 2 years after operation.
  • CONCLUSIONS: Through this combined approach, the advanced tonsillar carcinoma could be resected en bloc under direct visual field and keeping 1-1.5 cm safe margin to the tumor.
  • Neck dissection, preoperative chemotherapy and postoperative radiotherapy were supplemental measures.
  • Combined therapy was of great significance in reducing recurrence of the tumor.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Surgical Flaps. Tonsillar Neoplasms / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Pectoralis Muscles / surgery

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  • (PMID = 12768794.001).
  • [ISSN] 0412-3948
  • [Journal-full-title] Zhonghua er bi yan hou ke za zhi
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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27. Aaron S, Wong E, Tyrrell D, Duggan M, Vallieres E, Jewell L, Romanowski B, Doe PJ: Interferon treatment of multiple pulmonary malignancies associated with papilloma virus. Can Respir J; 2004 Sep;11(6):443-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interferon treatment of multiple pulmonary malignancies associated with papilloma virus.
  • Over a period of four years, beginning in spring 1988, a previously healthy man developed a primary squamous cell carcinoma of the tonsil, treated with radiotherapy, followed by 10 distinct, primary bronchial squamous cell carcinomas.
  • Four of the cancers were surgically resected, all of which were positive by hybridization for human papilloma virus (type 16).
  • The finding of papilloma virus in malignancies should prompt consideration of antiviral therapy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Antiviral Agents / therapeutic use. Bronchial Neoplasms / virology. Carcinoma, Squamous Cell / virology. Interferon-alpha / therapeutic use. Papillomaviridae. Tonsillar Neoplasms / virology
  • [MeSH-minor] Adult. Humans. Lung / pathology. Male. Palatine Tonsil / pathology. Papillomavirus Infections / complications. Papillomavirus Infections / drug therapy. Treatment Outcome

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  • (PMID = 15510252.001).
  • [ISSN] 1198-2241
  • [Journal-full-title] Canadian respiratory journal
  • [ISO-abbreviation] Can. Respir. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antiviral Agents; 0 / Interferon-alpha
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28. Gebhardt B, Herrmann K, Roessner A, Vorwerk U: [Differential diagnosis of unilateral necrotic tonsillitis]. Laryngorhinootologie; 2010 May;89(5):266-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Differential diagnosis of unilateral necrotic tonsillitis].
  • [Transliterated title] Differenzialdiagnostik der nekrotisierenden Tonsillitis.
  • In addition to this fusospirochetosis it is in case of necrotisising inflammations in the oropharynx differential-diagnostically important to consider also the anaerobic type Prevotella, especially Prevotella disiens as a potential trigger .
  • MATERIAL AND METHODS: Because the clinical course forms of a necrotisising oropharyngeal inflammations can be very different and complicate so a suitable diagnosis, it is very important to get a complete and perfect cause proof.
  • RESULTS: The type Prevotella consists of different species gram-negative, obligate anaerobic strains.
  • Next a carcinoma of the tonsil, Lues, Angina Plaut-Vincent have to be excluded.
  • However, the transmission is possible by insufficient hygiene, lack phenomena and sexual intercourse and to consider therefore as an exclusion diagnosis.
  • [MeSH-major] Bacterial Infections / diagnosis. Palatine Tonsil / pathology. Tonsillitis / diagnosis
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Bacteriological Techniques. Bacteroidaceae Infections / diagnosis. Bacteroidaceae Infections / pathology. Bacteroidaceae Infections / therapy. Diagnosis, Differential. Fusobacterium Infections / diagnosis. Fusobacterium Infections / pathology. Fusobacterium Infections / therapy. Gingivitis, Necrotizing Ulcerative / diagnosis. Gingivitis, Necrotizing Ulcerative / pathology. Gingivitis, Necrotizing Ulcerative / therapy. Humans. Necrosis. Oral Ulcer / diagnosis. Prevotella. Syphilis / diagnosis. Syphilis / drug therapy. Syphilis / pathology. Tonsillectomy

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  • (PMID = 20458657.001).
  • [ISSN] 1438-8685
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Number-of-references] 14
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29. Hu YR, Wu CQ, Liu YJ, Wang Y, Li X, Zhong H, Yu Y: [Clinical observation on effect of shenqi fanghou recipe in preventing and treating radiation injury in patients with head and neck tumor]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2005 Jul;25(7):623-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To observe the therapeutic effect of shenqi fanghou recipe (SFR) in preventing and treating radiation injury in patients with head and neck tumor.
  • METHODS: One hundred and forty patients with head and neck tumor, including nasopharyngeal carcinoma, carcinoma of tonsil or tongue, were randomly divided into 2 groups, 70 patients in the observed group were given modified SFR as adjuvant to radiotherapy, while 70 patients in the control group were treated with radiotherapy alone.
  • RESULTS: The degree of oropharyngeal mucosa reaction, dryness in mouth and radiation dermatitis in cervical region in the observed group was milder than those in the control group, and the radiation injury induced late stage sequelae, such as the degree of mouth-opening was better and the cervical muscular sclerosis was better in the observed group than in the control group, showing significant difference (P < 0.01).

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  • (PMID = 16089140.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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