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1. Lee SC, Kim KH, Kim SH, Lee NS, Park HS, Won JH: Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving multiple lung metastases that was effectively treated with high-dose chemotherapy. Cancer Res Treat; 2009 Dec;41(4):229-32

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  • [Title] Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving multiple lung metastases that was effectively treated with high-dose chemotherapy.
  • Choriocarcinoma in the testis is very rare, and it represents less than 1% (0.3%) of all the testicular germ cell tumors.
  • We report here on a case of choriocarcinoma with multiple lung metastases, and the patient has achieved continuous remission for 2 years after combination chemotherapy of BEP (bleomycin, etoposide and cisplatin) and sequential high-dose chemotherapy with autologous peripheral stem cell rescue.

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  • (PMID = 20057969.001).
  • [ISSN] 2005-9256
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2802842
  • [Keywords] NOTNLM ; Germ cell and embryonal / High-dose chemotherapy / Neoplasms / Testicular choriocarcinoma
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2. Castillo-Avila W, Piulats JM, Garcia Del Muro X, Vidal A, Condom E, Casanovas O, Mora J, Germà JR, Capellà G, Villanueva A, Viñals F: Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors. Clin Cancer Res; 2009 May 15;15(10):3384-95
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  • [Title] Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors.
  • PURPOSE: Germ cell tumors (GCT) of the testis are highly curable, but those patients who are refractory to cisplatin (CDDP)-based combination chemotherapy have a poor prognosis.
  • Therefore, identifying new alternatives for treatment remains a priority.
  • Several studies support an important role for angiogenesis in GCTs, suggesting that antiangiogenic treatment might be a good alternative.
  • In the present study, we evaluated the effect of sunitinib, CDDP, or the combination of both drugs using an orthotopic model of human testicular GCT.
  • EXPERIMENTAL DESIGN: Mice were implanted with four different testicular tumors: a yolk sac, two choriocarcinomas, and a CDDP-resistant choriocarcinoma variant induced in mice by continuous exposure to CDDP.
  • Mice were treated with vehicle, CDDP, sunitinib, or the combination of both drugs and their effects on tumors were analyzed.
  • RESULTS: We observed a significant inhibition in tumor growth accompanied by longer survival after sunitinib treatment.
  • Combination therapy with CDDP significantly enhanced these effects.
  • More importantly, tumor growth inhibition induced by sunitinib was also observed in the induced CDDP-resistant choriocarcinoma model.
  • CONCLUSIONS: Taken together, these results suggest that sunitinib might be a new alternative for treatment of CDDP-refractory patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Indoles / therapeutic use. Neoplasms, Germ Cell and Embryonal / drug therapy. Pyrroles / therapeutic use. Testicular Neoplasms / drug therapy. Xenograft Model Antitumor Assays
  • [MeSH-minor] Angiogenesis Inhibitors / administration & dosage. Angiogenesis Inhibitors / pharmacology. Angiogenesis Inhibitors / therapeutic use. Animals. Apoptosis / drug effects. Blotting, Western. Cell Line, Tumor. Cell Proliferation / drug effects. Cell Survival / drug effects. Cisplatin / administration & dosage. Cisplatin / pharmacology. Drug Resistance, Neoplasm. Drug Synergism. Humans. Male. Mice. Mice, Nude. Neovascularization, Pathologic / genetics. Neovascularization, Pathologic / metabolism. Neovascularization, Pathologic / prevention & control. Receptors, Platelet-Derived Growth Factor / genetics. Receptors, Platelet-Derived Growth Factor / metabolism. Receptors, Vascular Endothelial Growth Factor / genetics. Receptors, Vascular Endothelial Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Survival Analysis. Tumor Burden / drug effects

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  • (PMID = 19417025.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Indoles; 0 / Pyrroles; 0 / sunitinib; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; Q20Q21Q62J / Cisplatin
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3. Ishizuka O, Satoh T, Mizuno H, Mizusawa H, Seki S, Nishizawa O: [A difficult case of advanced testicular choriocarcinoma effectively treated by chemotherapy and resection of lung metastasis]. Gan To Kagaku Ryoho; 2004 Feb;31(2):263-5
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  • [Title] [A difficult case of advanced testicular choriocarcinoma effectively treated by chemotherapy and resection of lung metastasis].
  • We found testicular choriocarcinoma with multiple lung, liver, and brain metastases.
  • The patient received 5 courses of VIP therapy (cisplatin, etoposide, ifosfamide) and 1 course of high-dose chemotherapy (carboplatin, etoposide, cyclophospamide) with peripheral blood stem cell transplantation.
  • One year later, the patient underwent surgery for resection of lung metastasis after 1 course of chemotherapy (cisplatin, etoposide).
  • Pathological diagnosis showed a remnant of choriocarcinoma.
  • Three years and three months after surgery, no recurrence of the choriocarcinoma has been found.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / drug therapy. Choriocarcinoma / surgery. Lung Neoplasms / secondary. Testicular Neoplasms / drug therapy. Testicular Neoplasms / surgery
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Carboplatin / administration & dosage. Cisplatin / administration & dosage. Cyclophosphamide / administration & dosage. Drug Administration Schedule. Etoposide / administration & dosage. Humans. Ifosfamide / administration & dosage. Liver Neoplasms / secondary. Male. Peripheral Blood Stem Cell Transplantation. Pneumonectomy

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  • (PMID = 14997765.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; CEC protocol; ICE protocol 1; VP-P protocol
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4. Gersak B, Lakic N, Gorjup V, Gulic T, Berden P, Cernic NS: Right ventricular metastatic choriocarcinoma obstructing inflow and outflow tract. Ann Thorac Surg; 2002 May;73(5):1631-3
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  • [Title] Right ventricular metastatic choriocarcinoma obstructing inflow and outflow tract.
  • Additional chemotherapy was carried out according to the BEPO (etoposid, eisplatin, bleomycin, vincritin) scheme.
  • Histology revealed metastasis of a choriocarcinoma originating from the right testis.
  • Computed tomography performed after 6 months detected no metastases in the lungs.
  • [MeSH-major] Choriocarcinoma / secondary. Heart Neoplasms / secondary. Heart Ventricles. Testicular Neoplasms / surgery. Ventricular Outflow Obstruction / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Humans. Magnetic Resonance Imaging. Male. Vincristine / administration & dosage

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  • (PMID = 12022566.001).
  • [ISSN] 0003-4975
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEPV protocol
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5. Nakano A, Yoshida M, Harada T, Araki A, Pineda L, Iijima M, Sezer C, Zhou L, Maruyama R: Intratubular germ cell neoplasia of unclassified type occupying the whole testis accompanied by a small mature teratoma and metastatic choriocarcinoma and Sertoli cell-only tubules in the other testis. Pathol Int; 2003 Oct;53(10):726-32
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  • [Title] Intratubular germ cell neoplasia of unclassified type occupying the whole testis accompanied by a small mature teratoma and metastatic choriocarcinoma and Sertoli cell-only tubules in the other testis.
  • A 19-year-old man with mild mental retardation was diagnosed as having metastatic choriocarcinoma and a testicular tumor.
  • Histopathological examination of the resected testis revealed the presence of a small lesion of mature teratoma but no trace of choriocarcinoma.
  • The remaining seminiferous tubules were atrophic and lined by large atypical germ cells, which were diagnosed as intratubular germ cell neoplasia of the unclassified type (IGCNU).
  • A small area with prominent tubules was also observed.
  • Within this lesion, the tubules were dilated and contained several layers of cells with central necrosis.
  • Immunohistological comparison of staining for several biological markers (Ki-67, c-kit and placental alkaline phosphatase) between cells in the atrophic tubules and those in the dilated tubules indicated a progression of the latter cells to cells with a more proliferative ability.
  • In the opposite testis, examined at autopsy after death due to metastatic choriocarcinoma, all seminiferous tubules were lined by Sertoli cells only.
  • It was therefore assumed that the germ cell tumor of the combined histological type had primarily arisen in the background of IGCNU, and that choriocarcinoma had spontaneously regressed.
  • The early onset of these testicular neoplastic lesions strongly indicates their occurrence under the genetic background of gonadal dysplasia, the Sertoli cell-only syndrome.
  • [MeSH-major] Choriocarcinoma, Non-gestational / secondary. Germinoma / pathology. Neoplasms, Multiple Primary / pathology. Seminiferous Tubules / pathology. Sertoli Cells / pathology. Teratoma / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Drug Therapy. Fatal Outcome. Humans. Immunohistochemistry. Male. Organ Size

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  • (PMID = 14516326.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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6. Sahraoui S, Hassani AT, Ouhtatou F, Acharki A, Benider A, Kahlain A: [Pure choriocarcinoma of the testis: report of a case and review of the literature]. Ann Urol (Paris); 2001 Mar;35(2):125-8
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  • [Title] [Pure choriocarcinoma of the testis: report of a case and review of the literature].
  • [Transliterated title] Choriocarcinome pur du testicule: à propos d'un cas avec revue de la littérature.
  • We report a case of a young man 31 years old treated at the Ibn Rochd Oncology Center for a pure choriocarcinoma of the right testis.
  • The diagnosis was confirmed by pathological examination of the testis after orchidectomy.
  • The adjuvant treatment consisted in chemotherapy like using in germ cell neoplasm's of the testis.
  • During the evolution, partial remission (50%) was obtained after the third course and complete remission one month after the end of treatment.
  • [MeSH-major] Choriocarcinoma / surgery. Testicular Neoplasms / surgery

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  • (PMID = 11355283.001).
  • [ISSN] 0003-4401
  • [Journal-full-title] Annales d'urologie
  • [ISO-abbreviation] Ann Urol (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 26
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7. Harikumar R, Harish K, Aravindan KP, Thomas V: Testicular choriocarcinoma with gastric metastasis presenting as hematemesis. Indian J Gastroenterol; 2004 Nov-Dec;23(6):223-4
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  • [Title] Testicular choriocarcinoma with gastric metastasis presenting as hematemesis.
  • We report a 28-year-old man who presented with hematemesis due to choricarcinoma of testis metastatic to the stomach.
  • Testicular wedge biopsy confirmed mixed germ cell tumor, the choriocarcinomatous portion alone getting metastasized to the stomach.
  • He was initiated on chemotherapy with actinomycin-D, etoposide and methotrexate, but died due to multiple metastases to the lung and brain.
  • [MeSH-major] Choriocarcinoma / secondary. Hematemesis / etiology. Stomach Neoplasms / complications. Stomach Neoplasms / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / secondary. Fatal Outcome. Humans. Male

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  • (PMID = 15627667.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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8. Matveev VB, Volkova MI, Cherniev VA, Figurin KM, Mitin AV: [Retroperitoneal lymphadenectomy in disseminated non-seminoma germinogenic testicular tumors after chemotherapy in patients with elevated serum tumor markers]. Urologiia; 2010 May-Jun;(3):41-7
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  • [Title] [Retroperitoneal lymphadenectomy in disseminated non-seminoma germinogenic testicular tumors after chemotherapy in patients with elevated serum tumor markers].
  • Postchemotherapy retroperitoneal lymph node dissection (RLND) was performed in 70 testicular non-seminoma patients with elevated serum tumor markers (age median 27.0 +/- 8.1 years) from 1983 to 2008.
  • The prognostic group was not identified in 24 (34.3%) cases which started treatment in other hospitals.
  • All the patients received induction cisplatin-based chemotherapy following orchidectomy (first-line--24 (34.3%), second-line--46 (65.7%) which resulted in tumor shrinkage < 50% in 7 (10.0%), 51-90% in 23 (32.9%), > 90%--in 2 (2.9%) cases.
  • CT scan revealed residual retroperitoneal masses after chemotherapy in all the patients: < 2 cm--5 (7.1%), 2-5 cm--25 (35.7%), > 5 cm--40 (57.1%).
  • Further chemotherapy was not perspective in all 70 patients who further underwent retroperitoneal lymph node dissection (RLND).
  • Postoperative chemotherapy was given to 27 (38.6%) cases.
  • Complications developed in 12.9% (9/70) patients.
  • Histology revealed necrosis in 20 (28.6%), teratoma--in 26 (37.1%), cancer--in 24 (34.3%) specimens.
  • Prognostic factors for cancer in retroperitoneal pathology were the following: S > S1 (p = 0.013), intermediate or poor prognosis group IGCCCG (p = 0.014), absence of embryonal carcinoma (p = 0.003), the presence of choriocarcinoma in the testicular tumor (p = 0.028), second-line chemotherapy (p = 0.001), residual mass > 2 cm (p = 0.006).
  • Univariate analysis revealed an adverse impact on progressive-free survival of category S > S1 (p = 0.015), intermediate or poor prognostic group IGCCCG (p = 0.01), the presence of embryonal carcinoma (p = 0.020) and the absence of choriocarcinoma in the testicular tumor (p = 0.029), tumor shrinkage < 50% (p < 0.0001), incomplete RLND (p = 0.012), an incomplete effect of the combined treatment (p < 0.0001), cancer in the residual mass (p < 0.0001).
  • The multivariate analysis proved predictive value of an incomplete effect of the combined treatment (p < 0.0001).
  • Thus, selected testicular non-seminoma patients with elevated serum tumor markers are curable with surgery.
  • The best candidates for RLND in this group are patients without a tumor markers level increase during chemotherapy, with S1 category, good IGCCCG prognosis, tumor shrinkage > 50% and potentially respectable residual disease.
  • [MeSH-major] Biomarkers, Tumor / blood. Germinoma. Lymph Node Excision. Testicular Neoplasms

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  • (PMID = 20734877.001).
  • [ISSN] 1728-2985
  • [Journal-full-title] Urologii︠a︡ (Moscow, Russia : 1999)
  • [ISO-abbreviation] Urologiia
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; Q20Q21Q62J / Cisplatin
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9. Worster A, Sharma S, Mookadam F, Opie J: Acute presentation of choriocarcinoma: a case study and review of the literature. CJEM; 2002 Mar;4(2):111-4
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  • [Title] Acute presentation of choriocarcinoma: a case study and review of the literature.
  • We report an unusual case of a 27-year-old male with an acute presentation of choriocarcinoma.
  • The patient presented with unstable vital signs, severe anemia and a widened arterial pulse pressure following a several day history of testicular pain.
  • He was subsequently diagnosed as having testicular choriocarcinoma with multiple hepatic metastases and large hemorrhagic para-aortic lymph nodes.
  • The widened pulse pressure persisted during fluid resuscitation and correction of both the anemia and hypotension, and only narrowed after the initiation of chemotherapy.
  • A literature review indicates that metastatic testicular choriocarcinoma is a rare but aggressive malignancy that often presents with acute symptoms and signs that cause patients to seek emergency care.
  • We summarize the reported cases of "acute" testicular choriocarcinoma presentation and briefly discuss its relationship to widened arterial pulse pressure.

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  • (PMID = 17612431.001).
  • [ISSN] 1481-8035
  • [Journal-full-title] CJEM
  • [ISO-abbreviation] CJEM
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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10. Eid H, Mingfang L, Institoris E, Bodrogi I, Bak M: MRP expression of testicular cancers and its clinical relevance. Anticancer Res; 2000 Sep-Oct;20(5C):4019-22
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  • [Title] MRP expression of testicular cancers and its clinical relevance.
  • However, there is a lack of data regarding its expression in germ cell testicular tumors (GCTTs).
  • PATIENTS AND METHODS: MRP expression was examined by immunohistochemistry (IHC) using mouse monoclonal antibody (MRPm6) against human MRP in 56 testis cancer specimens.
  • RESULTS: All testis tumors, regardless of their histology, metastatic status and clinical stage gave positive signals.
  • Since germ cell tumors are very sensitive to chemotherapy, the role of MRP as mediator of drug resistance seems unconvincing in this malignancy.
  • [MeSH-major] ATP-Binding Cassette Transporters / analysis. Drug Resistance, Multiple. Testicular Neoplasms / pathology
  • [MeSH-minor] Animals. Antibodies, Monoclonal. Choriocarcinoma / pathology. Choriocarcinoma / surgery. Humans. Immunohistochemistry. Male. Mice. Multidrug Resistance-Associated Proteins. Neoplasm Proteins / analysis. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Seminoma / pathology. Seminoma / surgery. Teratoma / pathology. Teratoma / surgery. Testis / pathology. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 11268495.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / ATP-Binding Cassette Transporters; 0 / Antibodies, Monoclonal; 0 / Multidrug Resistance-Associated Proteins; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Protein p53
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11. Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M, Committee for Pediatric Solid Malignant Tumors in the Kyushu Area: Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan. J Pediatr Surg; 2002 Dec;37(12):1703-6
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  • [Title] Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
  • PURPOSE: This study aims to assess the prognostic factors and optimal treatments for malignant germ cell tumors (MGCT) in childhood.
  • The prognostic factors and treatments were assessed based on the 5-year survival rate. RESULTS:.
  • (1) Stage: 100% for stage I (n = 54), 75.0% for stage II (n = 4), 67.3% for stage III (n = 14), and 54.8% for stage IV (n = 33); Unknown: n = 12. (2) Primary site: 93.4% for the testis (n = 52), 86.7% for the ovary (n = 31), 56.9% for the sacrococcygeal (n = 21), and 60.6% for others (n = 12); unknown: n = 1. (3) Surgical intervention for primary tumor: 100% for stage I with a complete resection (n = 53), 78.4% for stage III, IV with a complete resection (n = 26), and 33.3% for stage III, IV with an incomplete resection (n = 21). (4) Type of chemotherapy for the stage III and IV: 83.9% for the PVB (cisplatin, vinblastin, bleomycin; n = 13), 66.7% for the VAC (vincristine, actinomycin D, cyclophosphamide; n = 6), and 47.1% for other regimens (n = 25).
  • CONCLUSIONS: An early stage, a diagnosis under 1 year of age and a primary site in the gonads were favorable prognosis factors, whereas histologic findings of choriocarcinoma and liver or lung metastasis were unfavorable.
  • Radical complete resection alone is a sufficient treatment for localized MGCT.
  • The PVB regimen is optimal chemotherapy for advanced MGCT; however, high-risk cases still may require more aggressive treatment.
  • [MeSH-major] Germinoma / diagnosis. Germinoma / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Female. Humans. Incidence. Infant. Infant, Newborn. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Neoplasm Staging. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / epidemiology. Ovarian Neoplasms / surgery. Prognosis. Retrospective Studies. Survival Rate. Testicular Neoplasms / diagnosis. Testicular Neoplasms / epidemiology. Testicular Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright 2002, Elsevier Science (USA). All rights reserved.
  • [CommentIn] J Urol. 2003 Sep;170(3):1040 [12926414.001]
  • (PMID = 12483635.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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12. Sarkar S, Kundu AK, Chakrabarti S: Lungs: victim of synchronous double malignancies. J Assoc Physicians India; 2007 Mar;55:235-7
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  • CT-guided FNAC from the mass lesion was consistent with the diagnosis of non-small cell lung carcinoma (NSCLC).
  • A lump in his left testis was detected during clinical examination.
  • Both FNAC and excisional biopsy of the testicular mass confirmed the diagnosis of immature teratoma with choriocarcinoma, a form of non-seminomatous germ cell tumour (NSGCT).
  • With chemotherapy all metastatic lesions of lung and SVC syndrome disappeared, and the tumour-marker levels decreased.
  • However, the opacity in RUZ progessed to involve right recurrent laryngeal nerve at thoracic inlet, metastasized to the brain, and the patient expired after 4th cycle of chemotherapy.
  • [MeSH-major] Choriocarcinoma / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Teratoma / diagnosis

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  • (PMID = 17598338.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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13. Gleizal A, Torossian JM, Geha H, Lebreton F, Beziat JL: [Testicular choriocarcinoma presenting as cutaneous metastasis. A case report and review of the literature]. Ann Chir Plast Esthet; 2005 Jun;50(3):237-41
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  • [Title] [Testicular choriocarcinoma presenting as cutaneous metastasis. A case report and review of the literature].
  • [Transliterated title] Les métastases cutanées révélatrices des choriocarcinomes: revue de la littérature. A propos d'une localisation nasale d'origine testiculaire.
  • Choriocarcinoma are germinal tumors from testicular cells in men or foetal trophoblast in women.
  • The authors report a case of angioma-like tumor in a 22-year-old man which was a cutaneous metastasis of a testicular carcinoma.
  • Diagnosis was of course histologic.
  • Testicular echography showed an intra testicular tumor, pulmonary and abdominal CT-scan showed multiple metastases.
  • Orchidectomy and retroperitoneal lymphadenectomy were performed before a general chemotherapy.
  • Patient died 14 months after diagnosis.
  • Only 11 cases of cutaneous metastasis of choriocarcinoma were found in the world literature (7 men and 4 women).
  • All cases showed diagnosis trap for plastic surgeon.
  • [MeSH-major] Choriocarcinoma / secondary. Nose Neoplasms / secondary. Skin Neoplasms / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Lung Neoplasms / secondary. Lymph Node Excision. Male. Orchiectomy. Tomography, X-Ray Computed

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  • (PMID = 15963845.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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14. Williams SB, Steele GS, Richie JP: Primary retroperitoneal lymph node dissection in patients with clinical stage IS testis cancer. J Urol; 2009 Dec;182(6):2716-20
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  • [Title] Primary retroperitoneal lymph node dissection in patients with clinical stage IS testis cancer.
  • PURPOSE: Initial management for clinical stage IS (persistently increased tumor markers) nonseminomatous germ cell tumor has evolved from primary retroperitoneal lymph node dissection to induction chemotherapy at most medical centers.
  • MATERIALS AND METHODS: We reviewed the charts of patients who underwent retroperitoneal lymph node dissection at Brigham and Women's Hospital, and Dana Farber Cancer Center from 1993 to 2008.
  • Positive lymph nodes were identified at retroperitoneal lymph node dissection in 9 patients (38%), including pure embryonal carcinoma in 6 (67%), combined embryonal carcinoma and teratoma in 1, embryonal carcinoma, choriocarcinoma and teratoma in 1, and only teratoma in 1.
  • Of the patients who underwent primary retroperitoneal lymph node dissection 5 (21%) also received chemotherapy postoperatively, which was due to persistently increased tumor markers in 3 (13%).
  • At surgery estimated blood loss was 175 cc, operative time was 3.1 hours and hospital stay was 3.9 days.
  • CONCLUSIONS: Patients with clinical stage IS are at significant risk for metastatic disease and can be successfully treated with primary retroperitoneal lymph node dissection, thereby sparing chemotherapy in most of them.
  • [MeSH-major] Lymph Node Excision / methods. Neoplasms, Germ Cell and Embryonal / surgery. Testicular Neoplasms / surgery

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  • [CommentIn] J Urol. 2009 Dec;182(6):2720 [19836765.001]
  • (PMID = 19836777.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Allan RW, Algood CB, Shih IeM: Metastatic epithelioid trophoblastic tumor in a male patient with mixed germ-cell tumor of the testis. Am J Surg Pathol; 2009 Dec;33(12):1902-5
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  • [Title] Metastatic epithelioid trophoblastic tumor in a male patient with mixed germ-cell tumor of the testis.
  • This report describes a rare case of a concurrent epithelioid trophoblastic tumor (ETT) and a teratoma in a para-aortic lymph node from a 39-year-old male patient with the initial diagnosis of testicular malignant mixed germ-cell tumor.
  • The metastatic lesion was excised 2 years after orchiectomy and chemotherapy.
  • Microscopically, the metastatic lesion contained a teratoma component and dispersed small nests of cohesive chorionic-type intermediate trophoblastic cells, closely resembling gestational ETT in female patients.
  • The diagnosis of ETT in this case was confirmed by stepwise immunohistochemistry.
  • Demonstration of ETT as one of the histologic manifestations of recurrent testicular germ-cell tumors should encourage pathologists to recognize this unique feature in assessing posttreatment mixed germ-cell neoplasm.
  • [MeSH-major] Carcinoma, Embryonal / secondary. Choriocarcinoma, Non-gestational / secondary. Epithelioid Cells / pathology. Teratoma / secondary. Testicular Neoplasms / pathology. Trophoblastic Neoplasms / secondary
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Female. Humans. Immunohistochemistry. Lymph Node Excision. Lymphatic Metastasis. Male. Orchiectomy. Treatment Outcome

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  • (PMID = 19898219.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Mikuz G: [WHO classification of testicular tumors]. Verh Dtsch Ges Pathol; 2002;86:67-75
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  • [Title] [WHO classification of testicular tumors].
  • [Transliterated title] WHO-Klassifikation der Hodentumoren.
  • Twenty years after the first edition (1977), the WHO has presented the updated version of the "Histological typing of testis tumours".
  • Such atypical cells appear in the tubules adjacent to the germ cell tumors, in some few cases (6%) also in the contra lateral healthy gonad and rarely in infertile men (1%).
  • The precursor lesion can progress to franc germ cell tumor starting probably with seminoma, which still maintain the capability of differentiation (pluripotente cells) in all other types of non-seminomatous germ cell tumors.
  • Seminoma with syncytiotrophoblastic cells is a variant which should not be confused with choriocarcinoma.
  • This is a harmless name for an extremely dangerous tumor in which one tissue overgrows the other and gives rise to somatic type sarcomas or carcinomas.
  • Such tumors do not respond like germ cell tumors to the usual chemotherapy.
  • Treatment should be tailored according to that used in standard management of the respective sarcoma or carcinoma.
  • In the comments it is mentioned that the testis carcinoid could be a part of teratoma, but the diagnosis is listed in the group of "miscellaneous" tumors together with tumors of ovarian epithelial type.
  • This is a very questionable decision because the normal testis does not contain neuroendocrine cells from which carcinoids would have to be able to develop.
  • The patients have cardiac myxomas, spotty skin pigmentation, hormone active nodular hyperplasia of the adrenals and soft tissue myxomas.
  • For the therapy of germ cell tumor an assessment of risk factors found by the pathologists is extremely important.
  • In the absence of such predictors a surveillance policy allows some patients to forgo chemotherapy.
  • [MeSH-major] Testicular Neoplasms / classification

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  • (PMID = 12647353.001).
  • [ISSN] 0070-4113
  • [Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie
  • [ISO-abbreviation] Verh Dtsch Ges Pathol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 48
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17. Khurana RN, DiBernardo C, Handa JT: Improved systemic chemotherapy for metastatic testicular choriocarcinoma can result in excellent prognosis for life and vision. Arch Ophthalmol; 2008 Jul;126(7):1008-9
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  • [Title] Improved systemic chemotherapy for metastatic testicular choriocarcinoma can result in excellent prognosis for life and vision.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma / drug therapy. Choroid Neoplasms / drug therapy. Lung Neoplasms / secondary. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Humans. Male. Orchiectomy. Prognosis. Visual Acuity. Vitreous Detachment / ultrasonography. Vitreous Hemorrhage / ultrasonography

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  • (PMID = 18625957.001).
  • [ISSN] 1538-3601
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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18. Ohno M, Narita Y: A case of pathological complete remission of a brain metastasis from germ cell tumor of the testis after systemic chemotherapy. Jpn J Clin Oncol; 2010 Dec;40(12):1201
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  • [Title] A case of pathological complete remission of a brain metastasis from germ cell tumor of the testis after systemic chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / drug therapy. Choriocarcinoma / drug therapy. Endodermal Sinus Tumor / drug therapy. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Chorionic Gonadotropin, beta Subunit, Human / blood. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Ifosfamide / administration & dosage. Male. Remission Induction. Tomography, X-Ray Computed

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  • (PMID = 21112974.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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