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1. Peterson M, Beck S, Bihrle R, Einhorn L, Foster R: Results of retroperitoneal lymph node dissection after chemotherapy in patients with pure seminoma in the orchidectomy specimen but elevated serum alpha-fetoprotein. BJU Int; 2009 Jul;104(2):176-8
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  • [Title] Results of retroperitoneal lymph node dissection after chemotherapy in patients with pure seminoma in the orchidectomy specimen but elevated serum alpha-fetoprotein.
  • OBJECTIVE: To determine the incidence of necrosis, teratoma, and active cancer in specimens at retroperitoneal lymph node dissection (RPLND) after chemotherapy in patients who presented with a pure seminoma primary tumour and an elevated serum alpha-fetoprotein (AFP) level at diagnosis who underwent surgery.
  • PATIENTS AND METHODS: A retrospective review of the Indiana University testis cancer database from 1980 to 2004 was performed to identify all patients with metastasic germ cell cancer, pure seminoma in the orchidectomy specimen, and an elevated AFP level.
  • In all, 42 patients were identified; two with nonseminomatous germ cell cancer in the contralateral testicle were excluded.
  • RESULTS: RPLND pathology in the 40 patients showed necrosis in 13 (32.5%), teratoma in 12 (30%), and cancer in 15 (37.5%).
  • The histological subtype of the 15 cancer specimens at RPLND was pure seminoma in two, embryonal in three, yolk sac in seven, variant in one, and mixed elements in two (one with seminoma and yolk sac, and one with embryonal and variant).
  • In all, 20 patients presented with a serum AFP level of <1000 microg/mL with nine (45%) having teratoma only in the retroperitoneum in contrast to 20 patients with an AFP level of >1000 microg/mL with three (15%) having teratoma only in the retroperitoneum (P = 0.04).
  • The level of serum AFP did not predict for active cancer in the retroperitoneum (P = 0.5).
  • CONCLUSIONS: RPLND in patients after chemotherapy who presented with pure seminoma in the orchidectomy specimen and an elevated AFP do not have a high probability of finding necrosis only in the RPLND specimen.
  • In fact, the prevalence of persistent cancer is higher compared with the general group of patients that have RPLND after chemotherapy.
  • [MeSH-major] Lymph Node Excision. Retroperitoneal Neoplasms / secondary. Seminoma / secondary. Testicular Neoplasms / pathology. alpha-Fetoproteins / metabolism
  • [MeSH-minor] Combined Modality Therapy. Humans. Male. Orchiectomy / methods. Retrospective Studies. Teratoma / pathology

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  • (PMID = 19493258.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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2. Labarthe P, Khedis M, Chevreau C, Mazerolles C, Thoulouzan M, Durand X, Soulie M, Rischmann P, Plante P, Thonneau P, Houlgatte A, Huyghe E: [Management of pure teratoma of the testis in adult, results of a multicenter study over 15 years]. Prog Urol; 2008 Dec;18(13):1075-81
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  • [Title] [Management of pure teratoma of the testis in adult, results of a multicenter study over 15 years].
  • [Transliterated title] Prise en charge du tératome pur testiculaire postpubertaire à propos d'une série multicentrique sur 15 ans.
  • OBJECTIVE: To analyze cases of pure teratoma of the testis (PTT) of a large population-based study, as such tumors are rare, and to make an update on the topic.
  • PATIENTS AND METHODS: We retrospectively reviewed the records of patients treated for PTT from 1987 to 2003 in the French Midi-Pyrenees region (southwestern France) and in the Val-de-Grâce military hospital, Paris.
  • Among more than 1000 cases of testis cancer, we identified 20 cases of PTT (4% of the whole population).
  • For the localized PTT patients, four out of eight out of 8 were on surveillance only after the orchiectomy, and the remaining four received adjuvant chemotherapy.
  • All patients with the metastatic disease were treated by chemotherapy followed by surgical removal of residual tumor masses.
  • With a mean of 125 months follow-up, 85% of the population did not relapse after treatment.
  • [MeSH-major] Teratoma / therapy. Testicular Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Humans. Male. Middle Aged. Prospective Studies. Time Factors. Young Adult

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  • (PMID = 19041814.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
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3. Mohanty SK, Balani JP, Parwani AV: Primitive neuroectodermal tumor arising in a testicular teratoma with retroperitoneal metastasis: report of an interesting case with review of literature. Urology; 2007 Oct;70(4):812.e7-10
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  • [Title] Primitive neuroectodermal tumor arising in a testicular teratoma with retroperitoneal metastasis: report of an interesting case with review of literature.
  • Teratomas with malignant transformation occur in approximately 3 to 6% of patients with metastatic germ cell tumors treated with platinum-based chemotherapy.
  • The histology of the nongerm cell (somatic) malignant elements most commonly includes carcinoma and various types of sarcomas; however, so far as the primitive neuroectodermal tumors (PNETs) are concerned the experience is quite limited.
  • There are only seven documented case reports and occasional series of PNET in association with testicular teratoma either in the primary site or in the metastatic location.
  • [MeSH-major] Neoplasms, Second Primary. Neuroectodermal Tumors, Primitive / pathology. Retroperitoneal Neoplasms / secondary. Teratoma / pathology. Testicular Neoplasms / pathology

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  • (PMID = 17991577.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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5. Stamatiou K, Papadopoulos P, Perlepes G, Galariotis N, Olympitis M, Moschouris H, Vasilakaki T: Mixed germ cell tumor of the testicle with ravdomuosarcomatous component: a case report. Cases J; 2009;2:9299
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  • [Title] Mixed germ cell tumor of the testicle with ravdomuosarcomatous component: a case report.
  • INTRODUCTION: Testicular tumors can be classified as seminomatous and non-seminomatous germ-cell tumor (NSGCT) types.
  • Here we present a rare case of a mixed germ cell tumor composed of seminoma, Yolk sack tumor and teratoma containing a sarcoma component of somatic type malignancy.
  • USG of the scrotum revealed a large right testis swelling characterized by scarce cystic elements and calcifications.
  • The patient underwent right-sided high orchidectomy and was given chemotherapy of the BEP regimen.
  • After the 2nd cycle the patient discontinued the chemotherapy and when he came for follow-up after a gap of 3 months, despite the normalisation in tumor markers values, the retroperitoneal mass was relapsed.
  • CONCLUSION: More than 50% of germ-cell tumors include more than 2 basic germ-cell tumor types, with the exception of spermatocytic seminoma.
  • About 90% of the patients with nonseminomatous tumors can achieve complete cure with aggressive chemotherapy and most of them can be cured.
  • Although prognosis of testicular tumors depends largely on clinical stage, histological type and adhesion to the treatment influence the prognosis as well.

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  • (PMID = 20062623.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803963
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6. Kasai T, Moriyama K, Tsuji M, Uema K, Sakurai N, Fujii Y: Adenocarcinoma arising from a mature cystic teratoma of the testis. Int J Urol; 2003 Sep;10(9):505-9
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  • [Title] Adenocarcinoma arising from a mature cystic teratoma of the testis.
  • Histopathological examination revealed a well-differentiated, mucinous adenocarcinoma originating from the gastrointestinal epithelium in a mature cystic teratoma (dermoid cyst) of the testis and metastatic mucinous adenocarcinoma of the skin.
  • We made a diagnosis of teratoma with malignant transformation (TMT) of the testis.
  • Combination chemotherapy with low-dose cisplatin/5'-deoxy-5-fluorouridine (CDDP/5'-DFUR) was initiated, but the patient died 8 months after orchiectomy.
  • At autopsy, similar mucinous adenocarcinoma of the testis and the skin were observed at the metastatic sites.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / secondary. Dermoid Cyst / diagnosis. Skin Neoplasms / secondary. Teratoma / diagnosis. Testicular Neoplasms / diagnosis

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  • (PMID = 12941133.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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7. Serrano P, Fantova A, Pascual M, Allué M, Gil MJ, Rioja LA: [The treatment of metastasic testicular pure mature teratoma]. Arch Esp Urol; 2006 Jun;59(5):524-6
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  • [Title] [The treatment of metastasic testicular pure mature teratoma].
  • [Transliterated title] Tratamiento del teratoma maduro puro de testiculo metastatizado. Qué hacer?
  • OBJECTIVE: Given the low frequency of testicular teratoma in relation to the rest of germ cell testicular tumors and the various treatment options for advanced stages, we report one case of advanced testicular mature teratoma with retroperitoneal adenopathy in which orchyectomy was performed after retroperitoneal lymphadenectomy, with the some pathology found in the primary tumor.
  • METHODS: We do an update on the treatment for these stages with the possibility of beginning with chemotherapy leaving lymphadenectomy for residual masses, or the contrary, being most cases treated in a mixed way.
  • CONCLUSIONS: Without clear evidence for guidelines in these tumors, it is recommended to individualize the treatment for each patient, accordingly to tumor characteristics, probability of relapse and follow-up.
  • [MeSH-major] Teratoma / secondary. Teratoma / surgery. Testicular Neoplasms / pathology. Testicular Neoplasms / surgery

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  • (PMID = 16903555.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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8. Fernández AJ, Papí M, Espuch D, Chillón S, Talavera J: [Cervical metastasis from testicular teratoma]. Acta Otorrinolaringol Esp; 2002 Feb;53(2):141-4
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  • [Title] [Cervical metastasis from testicular teratoma].
  • [Transliterated title] Metástasis cervical de teratoma testicular.
  • The presence of neck metastasis in patients with testicular germ cell neoplasms in a rare but well known phenomenon.
  • The incidence of neck metastasis in testicular carcinoma has been reported to be present in a 5% of cases.
  • When cervical metastasis occurs, surgical resection of the residual disease following chemotherapy and using a specific technique of modified neck dissection results in a surprisingly improvement of the prognosis.
  • [MeSH-major] Bone Neoplasms / secondary. Clavicle / pathology. Teratoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 11998529.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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9. Spiess PE, Pisters LL, Liu P, Pettaway CA, Kamat AM, Gomez JA, Tannir NM: Malignant transformation of testicular teratoma: a chemoresistant phenotype. Urol Oncol; 2008 Nov-Dec;26(6):595-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of testicular teratoma: a chemoresistant phenotype.
  • PURPOSE: To review our experience in the management of malignant transformation of teratoma (MTT).
  • RESULTS: Two patients presented with clinical stage I disease in which malignant transformation occurred within the primary testis tumor (rhabdomyosarcoma in 1 and adenocarcinoma in 1).
  • Of the remaining 7 patients, the clinical stages were IIA (N = 1), IIB (N = 3), and III (N = 3), and all were treated with chemotherapy followed by RPLND.
  • Following preoperative chemotherapy, a significant radiologic response (defined as more than a 25% reduction in maximum tumor circumferential diameter) was demonstrated in 1 patient, and normalization of serum tumor markers was demonstrated in 6.
  • CONCLUSIONS: In our experience, MTT is significantly resistant to current chemotherapeutic regimens, as demonstrated by its poor radiologic response to treatment.
  • Alternative therapeutic strategies targeted to MTT are thus needed.
  • [MeSH-major] Teratoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Drug Resistance, Neoplasm. Humans. Lymph Node Excision. Male. Neoplasm Staging. Retroperitoneal Space

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  • (PMID = 18367105.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS610854; NLM/ PMC4121060
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10. Stroosma OB, Delaere KP: Carcinoid tumours of the testis. BJU Int; 2008 May;101(9):1101-5
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  • [Title] Carcinoid tumours of the testis.
  • OBJECTIVE: To review previous reports of carcinoid (an endocrine tumour mostly of the gastrointestinal tract) tumours of the testis.
  • METHODS: Carcinoid tumours of the testis are rare and can be divided into primary carcinoid (group 1), testicular metastasis from another location (group 2) and carcinoid within a testicular teratoma (group 3).
  • A case of testicular carcinoid within our clinic prompted us to review previous reports; all the cases found were assessed for patient and tumour characteristics, diagnostic tools used, treatment and prognosis.
  • Seven patients in group 1 developed metastases.
  • Three patients with a primary carcinoid were treated with adjuvant chemotherapy (two) or radiotherapy (one), with unknown results.
  • All but one of the nine patients who died were known to have metastasis, either from a primary testicular carcinoid or testicular metastases from an intestinal carcinoid.
  • CONCLUSION: When a testicular carcinoid tumour is discovered, other tumour sites should be excluded.
  • The most useful diagnostic tools for this purpose seem to be urinary 5-hydroxyindoleacetic acid measurement, somatostatin receptor scintigraphy, computed tomography and video-capsule endoscopy.
  • Localized testicular carcinoid tumours have an excellent prognosis after orchidectomy.
  • [MeSH-major] Carcinoid Tumor / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Child. Humans. Hydroxyindoleacetic Acid / urine. Male. Middle Aged. Neoadjuvant Therapy. Orchiectomy / methods. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 18190641.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 54-16-0 / Hydroxyindoleacetic Acid
  • [Number-of-references] 54
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11. Berdjis N, Baldauf A, Kittner T, Manseck A, Wirth M: [Paraneoplastic hyperthyroidism in a patient with metastasizing teratocarcinoma and excessively high HCG]. Aktuelle Urol; 2003 Oct;34(6):407-9
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  • [Transliterated title] Paraneoplastische Hyperthyreose bei metastasiertem Teratokarzinom mit exzessiver HCG-Erhöhung.
  • Clinically manifest hyperthyroidism is a rare paraneoplastic syndrome in patients with excessive HCG production due to testicular cancer.
  • A 40-year-old patient with right testicular cancer (teratoma, embryonal cell carcinoma), diffuse pulmonary metastases and high serum HCG levels presented with symptomatic hyperthyroidism.
  • The patient received immediately thyrostatic therapy and 4 cycles of PEI chemotherapy (Cisplatin, Etoposide, Ifosfamide).
  • Thyroid function had returned to normal by the beginning of the second course of chemotherapy.
  • After right orchiectomy and resection of residual pulmonary masses which revealed vital tumor cells, two additional courses of chemotherapy were performed.
  • The patient is well and without evidence of disease 11 months after therapy.
  • All patients with testicular cancer and excessive HCG production should be evaluated for biochemical and clinical signs of hyperthyroidism and treated accordingly with antithyroidal medication and immediate cytoreductive chemotherapy.
  • [MeSH-major] Chorionic Gonadotropin / blood. Hyperthyroidism / diagnosis. Lung Neoplasms / secondary. Paraneoplastic Syndromes / diagnosis. Teratocarcinoma / secondary. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Antithyroid Agents / therapeutic use. Combined Modality Therapy. Humans. Lymphatic Metastasis. Male. Neoadjuvant Therapy. Orchiectomy. Pneumonectomy. Tomography, X-Ray Computed

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  • (PMID = 14579189.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antithyroid Agents; 0 / Chorionic Gonadotropin
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12. Barret JM, Kruczynski A, Etiévant C, Hill BT: Synergistic effects of F 11782, a novel dual inhibitor of topoisomerases I and II, in combination with other anticancer agents. Cancer Chemother Pharmacol; 2002 Jun;49(6):479-86
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  • This preclinical study was undertaken to investigate its potential for inclusion in combination chemotherapy regimens.
  • The in vitro cytotoxicity of F 11782 incubated simultaneously with the following drugs was investigated: aclarubicin, cisplatin, doxorubicin, etoposide, 5-fluorouracil, mitomycin C, paclitaxel, topotecan or vinorelbine.
  • METHODS: The combinations were first evaluated in vitro against the GCT27 human testicular teratoma cell line and then against the A549 human non-small cell lung cancer cell line using median effect analysis.
  • CONCLUSIONS: F 11782 appears to be a promising candidate for combination chemotherapy, especially with DNA-damaging agents.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Enzyme Inhibitors / pharmacology. Naphthalenes / pharmacology. Neoplasms / drug therapy. Pyrans / pharmacology. Topoisomerase I Inhibitors. Topoisomerase II Inhibitors. Tumor Cells, Cultured / drug effects
  • [MeSH-minor] Animals. Cell Division / drug effects. Cell Survival / drug effects. Dose-Response Relationship, Drug. Drug Evaluation, Preclinical. Drug Synergism. Drug Therapy, Combination. Female. Humans. Male. Mice

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  • (PMID = 12107553.001).
  • [ISSN] 0344-5704
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Enzyme Inhibitors; 0 / Naphthalenes; 0 / Pyrans; 0 / Topoisomerase I Inhibitors; 0 / Topoisomerase II Inhibitors; QN043X3ZDW / tafluposide
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13. Yoon GH, Stein JP, Skinner DG: Retroperitoneal lymph node dissection in the treatment of low-stage nonseminomatous germ cell tumors of the testicle: an update. Urol Oncol; 2005 May-Jun;23(3):168-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal lymph node dissection in the treatment of low-stage nonseminomatous germ cell tumors of the testicle: an update.
  • Nonseminomatous germ cell tumors (NSGCT) of the testicle are highly treatable and curable.
  • The evolution of cancer control for this disease has shown an effective integration of medical and surgical approaches over the last 3 decades.
  • Current emphasis in the therapy of NSGCT focuses on minimizing treatment-related morbidity while maintaining consistently high cure rates as previously seen.
  • Retroperitoneal lymph node dissection (RPLND) in experienced hands is a critical component of the treatment armamentarium in this disease.
  • RPLND is an accurate staging tool providing important information to determine the need for chemotherapy.
  • Teratoma is chemoresistant and, when present in the primary tumor of patients with low stage, may be best treated with primary RPLND.
  • Primary chemotherapy in the treatment of low stage NSGCT deserves continual investigation as long-term toxicities become more apparent.
  • [MeSH-major] Lymph Node Excision. Neoplasm Staging / methods. Neoplasms, Germ Cell and Embryonal / pathology. Neoplasms, Germ Cell and Embryonal / surgery. Testicular Neoplasms / pathology. Testicular Neoplasms / surgery

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  • (PMID = 15907716.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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4. Sundström J, Pelliniemi LJ, Salminen E, Pöllänen P, Abdelwahid E, Veräjänkorva E, Söderström KO: Effect of etoposide on experimental testicular teratoma in 129/SvJ mice. Virchows Arch; 2000 Jun;436(6):608-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of etoposide on experimental testicular teratoma in 129/SvJ mice.
  • To study the effects of etoposide on experimental testicular teratoma in 129/SvJ mouse we analysed the tumour growth, differentiation, apoptosis and the localisation of mdr1 P-glycoprotein (mdr1-Pgp).
  • In this model the implanted gonadal ridges developed into testicular teratomas in 17 out of 56 implanted testes (30%) and in 14 out of 28 mice (50%).
  • The teratomas consisted mainly of neural tissue.
  • The etoposide-treated 4-week teratomas, but not the 6-week teratomas, were significantly smaller than those in the corresponding control groups.
  • The decreased proportion of immature neuroectodermal tissue components was observed in all treated teratomas, converting the histology towards that of a mature teratoma.
  • In addition, a low proportion of immature tissue components was frequently combined with a low density of apoptotic cells.
  • In conclusion, etoposide decreased the immature tissue components of teratomas, while mature tissues remained unaffected.
  • These results may have clinical relevance in man, since they confirm that postchemotherapy mature teratomas cannot be treated with chemotherapy.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Etoposide / therapeutic use. Teratoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Animals. Apoptosis. DNA Fragmentation. Disease Models, Animal. Drug Resistance. Immunohistochemistry. Injections, Intraperitoneal. Male. Mice. Mice, Inbred Strains. P-Glycoprotein / analysis

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  • (PMID = 10917177.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / P-Glycoprotein; 6PLQ3CP4P3 / Etoposide
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15. Jones GY, Payne S: Searching for safety signals: the experience of medical surveillance amongst men with testicular teratomas. Psychooncology; 2000 Sep-Oct;9(5):385-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Searching for safety signals: the experience of medical surveillance amongst men with testicular teratomas.
  • The aim of this study is to compare the experience of a group of men with Stage 1 testicular teratomas who were being managed through a surveillance programme (n=25) with a group of patients who had received chemotherapy for more advanced disease (n=22).
  • Twelve (48%) of the men assigned to the surveillance programme scored in the 'borderline' or 'clinical case' range on the anxiety subscale of the HADS, compared with six (27%) in the chemotherapy group.
  • There was a significant negative correlation in the surveillance group between 'time since diagnosis' and an elevated anxiety subscale score on the HADS.
  • [MeSH-major] Adaptation, Psychological. Chemotherapy, Adjuvant / psychology. Teratoma / psychology. Testicular Neoplasms / psychology

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  • [Copyright] Copyright 2000 John Wiley & Sons, Ltd.
  • (PMID = 11038476.001).
  • [ISSN] 1057-9249
  • [Journal-full-title] Psycho-oncology
  • [ISO-abbreviation] Psychooncology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] ENGLAND
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16. Fujita K, Wada R, Sakurai T, Sashide K, Fujime M: Primary carcinoid tumor of the testis with teratoma metastatic to the para-aortic lymph node. Int J Urol; 2005 Mar;12(3):328-31
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  • [Title] Primary carcinoid tumor of the testis with teratoma metastatic to the para-aortic lymph node.
  • A primary testicular carcinoid tumor with teratoma metastasized to the para-aortic lymph node.
  • Chemotherapy consisting of cisplatin, etoposide and bleomycin was not effective on the metastatic lesions.
  • [MeSH-major] Carcinoid Tumor / surgery. Teratoma / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Aorta, Abdominal. Humans. Lymph Node Excision. Lymphatic Diseases. Lymphatic Metastasis. Male. Middle Aged. Orchiectomy


17. Yoon GH, Stein JP, Skinner DG: Retroperitoneal lymph node dissection in the treatment of low-stage nonseminomatous germ cell tumors of the testicle. Expert Rev Anticancer Ther; 2005 Feb;5(1):75-85
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  • [Title] Retroperitoneal lymph node dissection in the treatment of low-stage nonseminomatous germ cell tumors of the testicle.
  • Nonseminomatous germ cell tumors of the testicle are highly treatable and curable.
  • The evolution of cancer control for this disease has demonstrated an effective integration of medical and surgical approaches over the last 30 years.
  • Current emphasis in the therapy of nonseminomatous germ cell tumors focuses on minimizing treatment-related morbidity while maintaining consistently high cure rates.
  • Retroperitoneal lymph node dissection in experienced hands is a critical component of the treatment armamentarium in this disease.
  • Retroperitoneal lymph node dissection is an accurate staging tool that provides important information in determining the need for chemotherapy.
  • Teratoma is known to be chemoresistant and, when present in the primary tumor of low-stage patients, may be best treated with primary retroperitoneal lymph node dissection.
  • Primary chemotherapy in the treatment of low-stage nonseminomatous germ cell tumors deserves continual investigation as long-term toxicities become more apparent.
  • [MeSH-major] Lymph Node Excision / methods. Neoplasms, Germ Cell and Embryonal / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Laparoscopy. Male. Neoplasm Staging. Prognosis. Retroperitoneal Space. Risk Factors

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  • (PMID = 15757440.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 59
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18. Narducci F, Lambaudie E, Houvenaeghel G, Collinet P, Leblanc E: Early experience of robotic-assisted laparoscopy for extraperitoneal para-aortic lymphadenectomy up to the left renal vein. Gynecol Oncol; 2009 Oct;115(1):172-4
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  • The patients included a man with a pT2 non-seminomatous germ cell tumour of the left testicle treated by chemotherapy with an incomplete response (mature teratoma), four women with locally advanced cervical cancer, and one case of bulky cancer of the vaginal cuff.
  • The procedure was carried out using four port sites: one for the camera, one each for the no. 1 and no. 3 arms of the Da Vinci robot system, and one for the assistant.
  • A larger prospective study is now required to evaluate this procedure further.
  • [MeSH-major] Testicular Neoplasms / surgery. Uterine Cervical Neoplasms / surgery. Vaginal Neoplasms / surgery

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  • (PMID = 19450870.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Porcaro AB, Antoniolli SZ, Martignoni G, Brunelli M, Curti P: Adult primary teratoma of the testis--report on 5 cases in clinical stage I disease. Int Urol Nephrol; 2001;33(4):657-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult primary teratoma of the testis--report on 5 cases in clinical stage I disease.
  • OBJECTIVES: Testis pure teratoma accounts for 2.7% to 3% of all germ cell tumors in adult where it behaves as a malignant neoplasm.
  • Pure teratoma of the testis presents in clinical stage I disease in 44% of the patients whose risk of having pathological stage II disease is 16.7% to 19.2%.
  • Herein we report on 5 cases of adult pure teratoma of the testis presenting itself in clinical stage I disease.
  • MATERIALS AND METHODS: From September 1976 to February 2000, 75 patients underwent orchidectomy for clinical stage I nonseminomatous germ cell cancer of the testis.
  • Testis pure teratoma was detected in 5 patients (7%).
  • Testis tumor markers were evaluated in all cases.
  • Treatment options after orchidectomy included retroperitoneal lymph node dissection (RPLND) in 4 patients and surveillance in 1.
  • Histopathology detected the following subtypes: mature teratoma in 3 cases (60%), immature teratoma in 1 (20%) and teratoma with malignant transformation in (20%).
  • Germ cell cancer microscopic metastatic disease including embryonal carcinoma was detected in I dissected lymph node of 1/4 patients (25%).
  • CONCLUSIONS: Primary pure teratoma of the testis does not respond to chemotherapy nor does it to radiation therapy.
  • The disease treatment options after orchidectomy for patients with clinical stage I disease include RPLND or surveillance with their relative risks and benefits.
  • RPLND is the chosen treatment because it is both staging and treating.
  • A close a long term follow up is required since pure teratoma metastatic disease may clinically develop after more than 10 years.
  • [MeSH-major] Orchiectomy. Teratoma / surgery. Testicular Neoplasms / surgery

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  • (PMID = 12452623.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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20. Carver BS, Al-Ahmadie H, Sheinfeld J: Adult and pediatric testicular teratoma. Urol Clin North Am; 2007 May;34(2):245-51; abstract x
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adult and pediatric testicular teratoma.
  • Although pure testicular teratomas in prepubertal boys have not been reported to metastasize, testicular teratomas in adults are associated with clinical metastases in 60% of cases.
  • Teratoma has a diverse biological potential, with propensity for local growth, distant metastases, and transformation to somatic malignant cell types.
  • Teratoma is frequently found associated with other nonseminomatous histologies and is present in the retroperitoneum in 40% of postchemotherapy retroperitoneal lymph node dissections.
  • Because of the chemoresitant nature of teratomas, complete surgical resection is the treatment of choice.
  • Since the biology of teratoma is unpredictable and it is frequently found in the retroperitoneum following chemotherapy for nonseminomatous germ-cell tumors, complete control of the retroperitoneum is advocated for all patients regardless of residual mass size.
  • [MeSH-major] Teratoma. Testicular Neoplasms
  • [MeSH-minor] Adult. Clinical Trials as Topic. Humans. Male. Neoplasm Staging. Treatment Outcome

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  • (PMID = 17484929.001).
  • [ISSN] 0094-0143
  • [Journal-full-title] The Urologic clinics of North America
  • [ISO-abbreviation] Urol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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21. Zangana AM, Razak AB: A giant testicular teratoma. Saudi Med J; 2007 Mar;28(3):465-7
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  • [Title] A giant testicular teratoma.
  • We report a giant testicular in a 36-year-old farmer man, of 18-month duration admitted to the Surgical Department Erbil Teaching Hospital, Iraq.
  • Histological examination revealed mature and immature teratoma.
  • Six weeks later after a course of chemotherapy and radiotherapy, the patient underwent resection of metastatic lung lesion.
  • [MeSH-major] Lung Neoplasms / secondary. Lymph Nodes / pathology. Neoplasm Invasiveness / pathology. Penile Neoplasms / secondary. Teratoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Iraq. Lymph Node Excision. Male. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 17334483.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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22. Pectasides D, Glotsos J, Bountouroglou NG, Dadioti PA, Athanassiou AE: Primary carcinoid of the testis with metastases. Case report and review of the literature. J BUON; 2002 Apr-Jun;7(2):153-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary carcinoid of the testis with metastases. Case report and review of the literature.
  • Primary carcinoid of the testis is an extremely rare neoplasm, making up 0.23% of all testicular neoplasms.
  • The vast majority of the reported cases are primary carcinoids and 20-25% are associated with teratomas.
  • We present a case of a 50-year-old man with a primary testicular carcinoid who developed lymph node and lung metastases 4 months after left inguinal orchidectomy.
  • Our case was not associated with testicular teratoma or carcinoid syndrome.
  • Vigorous efforts were done postoperatively to exclude the possibility of carcinoid tumor metastatic to the testis.
  • Our patient achieved a mixed response (lung metastases: complete response, lymph node metastases: partial response) with combined therapy that included chemotherapy (cisplatin, etoposide, ifosfamide, epirubicin), octreotide and radiotherapy to the metastatic lymph nodes.
  • We herein review the literature and discuss all the possibilities to explain the origin of carcinoid tumors of the testis.

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  • (PMID = 17577281.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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