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1. Chang YL, Wu CT, Lee YC: Mediastinal and retroperitoneal teratoma with focal gastrointestinal adenocarcinoma. J Thorac Oncol; 2006 Sep;1(7):729-31
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  • [Title] Mediastinal and retroperitoneal teratoma with focal gastrointestinal adenocarcinoma.
  • We report an unusual case of gastrointestinal adenocarcinoma arising in a giant posterior mediastinal mature cystic teratoma extending into the retroperitoneum, which was treated by complete excision with a good outcome for more than 2 years.
  • Teratomas with malignant transformation are rare non-germ cell malignant tumors arising from a preexisting mature teratoma.
  • Strong cytokeratin 20 cytoplasmic immunostaining of the tumor cells supported the diagnosis of gastrointestinal adenocarcinoma.
  • In this report, we describe the potential aggressiveness of a giant mature cystic teratoma with adenocarcinoma and suggest that complete surgical resection without adjuvant chemotherapy be considered as a therapy in the treatment of teratoma with focal malignant transformation.
  • [MeSH-major] Adenocarcinoma / pathology. Gastrointestinal Neoplasms / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Retroperitoneal Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 17409945.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Bilici A, Ustaalioglu BB, Seker M, Kayahan S: Case report: soft tissue metastasis from immature teratoma of the testis: second case report and review of the literature. Clin Orthop Relat Res; 2010 Sep;468(9):2541-4
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  • [Title] Case report: soft tissue metastasis from immature teratoma of the testis: second case report and review of the literature.
  • BACKGROUND: Testicular cancer, like other histopathologic types, commonly metastasizes to the lungs, liver, and brain.
  • Spread to soft tissue, however, is rare with only four cases with seminoma reported.
  • However, one case with metastasis of testicular immature teratoma to soft tissue was documented previously.
  • CASE DESCRIPTION: We report the case of a 38-year-old man with recurrent immature teratoma of the testis who presented with a painless soft tissue mass in the left thigh previously treated with standard chemotherapy.
  • After removal of the soft tissue mass, his serum alpha-fetoprotein level had returned to the normal range.
  • LITERATURE REVIEW: To our knowledge, this is the second case of immature teratoma of the testis metastasized to soft tissue.
  • PURPOSES AND CLINICAL RELEVANCE: We suggest that for a man with testicular cancer who has a soft tissue mass, metastasis of soft tissue from testicular cancer and other solid malignancies should be considered in the differential diagnosis of a soft tissue mass together with primary soft tissue sarcoma.
  • [MeSH-major] Soft Tissue Neoplasms / secondary. Teratoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Brain Neoplasms / therapy. Chorionic Gonadotropin, beta Subunit, Human / blood. Cranial Irradiation. Humans. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Magnetic Resonance Imaging. Male. Orchiectomy. Thigh. Treatment Outcome. alpha-Fetoproteins / metabolism

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  • [Cites] Skeletal Radiol. 2000 May;29(5):270-4 [10883446.001]
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  • (PMID = 19937408.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
  • [Number-of-references] 17
  • [Other-IDs] NLM/ PMC2919860
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3. Besse B, Grunenwald D, Fléchon A, Caty A, Chevreau C, Culine S, Théodore C, Fizazi K: Nonseminomatous germ cell tumors: assessing the need for postchemotherapy contralateral pulmonary resection in patients with ipsilateral complete necrosis. J Thorac Cardiovasc Surg; 2009 Feb;137(2):448-52
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  • OBJECTIVES: Our objective was to explore the pathologic components of residual masses after primary chemotherapy in patients with metastatic nonseminomatous germ cell tumors.
  • METHODS: A multicenter retrospective study was conducted of 71 patients with thoracic residual masses (39 patients had bilateral lung metastasis) after first-line cisplatin-based chemotherapy for disseminated nonseminomatous germ cell tumors.
  • RESULTS: Pathologic findings in postchemotherapy residual masses included complete necrosis, teratoma, and viable cancer in 31%, 55%, and 14% of patients, respectively.
  • Discordant pathologic findings were evidenced between retroperitoneal lymph node and thoracic (lung or mediastinal lymph nodes) residual masses in 27% of patients.
  • Among patients who had necrosis only in residual masses from their first lung (n = 20), 19 (95%) also had necrosis only in contralateral lesions.
  • A single patient had necrosis only in the first lung and some teratoma in the contralateral lung.
  • Avoiding contralateral lung surgery could therefore be considered when complete necrosis is found in the first lung after induction chemotherapy for nonseminomatous germ cell tumor.
  • [MeSH-major] Lung Neoplasms / secondary. Lung Neoplasms / surgery. Neoplasms, Germ Cell and Embryonal / drug therapy. Pneumonectomy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Choriocarcinoma / drug therapy. Choriocarcinoma / pathology. Cisplatin / therapeutic use. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / pathology. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Mediastinal Neoplasms / secondary. Necrosis. Retroperitoneal Neoplasms / secondary. Retrospective Studies. Teratoma / drug therapy. Teratoma / pathology. Young Adult

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  • (PMID = 19185168.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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4. Kita M, Sasaki Y, Okuyama M, Saga Y, Hashimoto H, Kaneko S, Yachiku S, Tokumitsu M, Inada F, Ishida H: [Pulmonary rhabdomyosarcoma generated during treatment of testicular tumor]. Nihon Hinyokika Gakkai Zasshi; 2003 Nov;94(7):696-700
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  • [Title] [Pulmonary rhabdomyosarcoma generated during treatment of testicular tumor].
  • He had undergone right high orchiectomy, chemotherapy with four courses of PEB regimen (cisplatin, etoposide, bleomycin) and retroperitoneal lymph node dissection the previous year.
  • The pathological findings showed mixed germ cell tumor (seminoma, yolk sac tumor, embryonal carcinoma) in the testis and mature teratoma in the draining lymph node.
  • Two courses of salvage chemotherapy using a VIP regimen (etoposide, ifosfamide, cisplatin) were performed after diagnosis of pulmonary metastases, but had no affect on tumor size.
  • Video-assisted excision of pulmonary metastases was then performed, giving a pathological diagnosis of rhabdomyosarcoma in all three resected tumors.
  • The operation was followed by three courses of CYVADIC (cyclophosphamide, vincristine, adriamycin, dacarbazin) chemotherapy and oral cyclophosphamide, as a small residual tumor was suspected.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lung Neoplasms / secondary. Rhabdomyosarcoma / secondary. Testicular Neoplasms / therapy
  • [MeSH-minor] Adult. Carcinoma, Embryonal / pathology. Carcinoma, Embryonal / therapy. Cisplatin / administration & dosage. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Dacarbazine / administration & dosage. Doxorubicin / administration & dosage. Drug Administration Schedule. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / therapy. Etoposide / administration & dosage. Humans. Ifosfamide / administration & dosage. Lymph Node Excision. Male. Orchiectomy. Pneumonectomy. Seminoma / pathology. Seminoma / therapy. Vincristine / administration & dosage

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  • (PMID = 14672002.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; CYVADIC protocol; ICE protocol 1
  • [Number-of-references] 15
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5. Ponce de León Roca J, Villavicencio Mavrich H: [Growing teratoma syndrome]. Arch Esp Urol; 2000 Jul-Aug;53(6):547-52
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  • [Title] [Growing teratoma syndrome].
  • [Transliterated title] Síndrome del "Growing teratoma".
  • OBJECTIVE: To review our series of patients with the growing teratoma syndrome (GTS) and to compare our results with those reported in the literature.
  • METHODS: We reviewed the clinical records of our series of patients with GTS for age, location of the tumor mass before and after chemotherapy, clinical stage according to the Royal Marsden Hospital Classification, histological pattern of the primary tumor, number and type of surgical procedures performed and clinical course.
  • The mean age at the time of diagnosis was 23 years.
  • Histological analysis of the primary tumor showed mature teratoma in 11, ectodermal sinus tumor in 8, and both histological types in 4.
  • A total of 33 surgical procedures were performed: 25 retroperitoneal lymphadenectomy (7 with retrocrural involvement), 4 thoracotomy with segmental lung resection, 2 resection of supraclavicular adenopathy, 1 resection of liver metastasis, and 1 resection of inguinal adenopathy.
  • The 25 retroperitoneal lymphadenectomy performed due to GTS account for 16.2% of the 154 retroperitoneal lymphadenectomies that were performed during the same time period.
  • Follow-up showed recurrence in 10 patients (58.8%); 7 had mature teratoma and 3 had malignant tumor.
  • CONCLUSIONS: Mature teratoma lesions can appear in different sites, the most frequent being the retroperitoneum and lung.
  • These lesions can appear before or during chemotherapy or after a disease-free interval.
  • The treatment of choice is resection of the mass, if possible in a single session to prevent malignant degeneration or compression of the adjacent structures.
  • We institute treatment early since an increase in size will make surgical treatment difficult, compromise organs and favor recurrence.
  • [MeSH-major] Teratoma. Testicular Neoplasms

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  • (PMID = 11002523.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] SPAIN
  • [Number-of-references] 25
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6. Tomasković I, Sorić T, Trnski D, Ruzić B, Kraus O: Giant testicular mixed germ cell tumor. a case report. Med Princ Pract; 2004 Mar-Apr;13(2):111-3
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  • At the time of presentation the tumor measured 29 x 20 x 16 cm, with a weight of 4,850 g.
  • Histopathology revealed a mixed germ cell tumor containing 80% of yolk sack tumor, 10% of teratoma and 10% of embryonal carcinoma.
  • Orchiectomy and chemotherapy were successful in the treatment of primary tumor and bilateral lung metastases.
  • [MeSH-major] Germinoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Male. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2004 S. Karger AG, Basel
  • (PMID = 14755145.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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7. Kinebuchi Y, Ogawa T, Kato H, Igawa Y, Nishizawa O, Miyagawa S: Testicular cancer with tumor thrombus extending to the inferior vena cava successfully removed using veno-venous bypass: a case report. Int J Urol; 2007 May;14(5):458-60
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  • A 33-year-old man with a left testicular tumor was referred to Shinshu University Hospital for advanced therapy.
  • After orchidectomy, a diagnosis of embryonal carcinoma was made with a clinical stage of T1N2M1bS3, which has a poor prognosis, based on the International Germ Cell Cancer Collaborative Group consensus.
  • After eight courses of chemotherapy, the patient's tumor markers normalized and the lung metastases disappeared, but the RPLN and tumor thrombus remained.
  • The pathological examination of the thrombus revealed a mature teratoma.

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  • (PMID = 17511736.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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8. Minamide M, Hosoi I, Yanagi S: [CA19-9-producing testicular tumor: a case report]. Hinyokika Kiyo; 2000 Jan;46(1):45-7
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  • Ultrasonography and computed tomography demonstrated a right testicular tumor with right lung metastasis and aortocaval lymph node metastasis.
  • The histopathological diagnosis was mixed type of teratoma, yolk sac tumor, embryonal carcinoma and seminoma.
  • After 5 courses of combination chemotherapy, the operation for right lung metastasis was performed.
  • He has been free of recurrence for about 18 months after the lung operation.
  • [MeSH-major] Biomarkers, Tumor / analysis. CA-19-9 Antigen / analysis. Carcinoma, Embryonal / diagnosis. Endodermal Sinus Tumor / diagnosis. Neoplasms, Multiple Primary. Seminoma / diagnosis. Teratoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Humans. Male. Orchiectomy. Treatment Outcome. Vinblastine / administration & dosage

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  • (PMID = 10723665.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; PVB protocol
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9. Ondrus D, Hornák M, Breza J, Mat'oska J, Schnorrer M, Belan V, Kausitz J: Delayed orchiectomy after chemotherapy in patients with advanced testicular cancer. Int Urol Nephrol; 2001;32(4):665-7
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  • [Title] Delayed orchiectomy after chemotherapy in patients with advanced testicular cancer.
  • INTRODUCTION: The therapeutic procedures in the management of testicular cancer are determined by histological findings in the removed testis and by the extent of the disease at the time of diagnosis.
  • However, all advanced tumors could be treated by primary chemotherapy regardless of the histological findings.
  • When the diagnosis of advanced tumor is evident, it is possible to start the treatment without orchiectomy.
  • The aim of this study was to evaluate the advantages of neo-adjuvant chemotherapy with delayed orchiectomy in the management of advanced testicular cancer.
  • MATERIAL AND METHODS: A total of 36 patients with advanced germ cell testicular cancer underwent primary PVB or BEP chemotherapy without previous orchiectomy.
  • The patients were treated with cisplatin-containing combination chemotherapy.
  • Following completion of chemotherapy, orchiectomy was performed alone or simultaneously with retroperitoneal lymph node dissection (RPLND) and/or lung metastasectomy in cases with persistent residual mass.
  • Following orchiectomy the patients were regularly checked and in cases with viable malignant tumor found in the testis sequential chemotherapy was administered.
  • Similarly when the relapse of the disease was detected, the patients were treated with sequential chemotherapy.
  • RESULTS: Complete disappearance of metastases was observed in 12 patients following chemotherapy alone.
  • The viable tumor in the removed tissue was found in one patient.
  • Delayed orchiectomy was performed simultaneously with surgical removal of residual mass in the retroperitoneum in 24 patients and as a separate procedure in 12 patients who have been considered to be complete responders following chemotherapy alone.
  • Residual viable tumor in testicular specimen was found in three patients, necrotic or fibrotic tissue in 18, and mature teratoma in 15 patients.
  • Overall survival of the patients was 26/36 (72.7%) at mean of 56.9 months (range 7-145 months, median 50 months) since the start of the treatment.
  • CONCLUSIONS: In patients with advanced germ cell testicular cancer preference must be given to the early beginning of intensive chemotherapy without the need of tissue diagnosis of primary tumor that should be obtained by orchiectomy.
  • Benefit of this therapeutic approach is the timely management of acute abdominal and/or pulmonary symptoms of life-threatening distant metastases.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / therapeutic use. Cisplatin / therapeutic use. Germinoma / drug therapy. Orchiectomy. Testicular Neoplasms / drug therapy. Vinblastine / therapeutic use
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm, Residual. Survival Rate. Teratoma / secondary. Time Factors. Treatment Outcome

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  • (PMID = 11989561.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; PVB protocol
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10. Yatsuyanagi E, Kusajima K, Suzuki M, Hirano T, Sakurada T, Kikuchi Y, Sugawara Y: [Induction chemotherapy and radical resection for primary nonseminomatous mediastinal germ cell tumor (NSGCT); report of a case]. Kyobu Geka; 2004 Feb;57(2):168-71
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  • [Title] [Induction chemotherapy and radical resection for primary nonseminomatous mediastinal germ cell tumor (NSGCT); report of a case].
  • A 15-year-old male was admitted to our hospital for treatment of an anterior mediastinal tumor.
  • Computed tomography (CT) revealed a heterogeneous solid tumor located in the anterior mediastinum.
  • Although CT-guided needle biopsy had been performed twice, histologic diagnosis could not be confirmed.
  • We believed this tumor to be nonseminomatous mediastinal germ cell tumor (NSGCT) and started intensive chemotherapy with cisplatin (CDDP) without histologic diagnosis because his serum AFP level was rapidly increasing.
  • After 2 courses of chemotherapy, his serum AFP level returned to the normal range and surgical resection of the tumor with part of right lung was performed.
  • Histopathological examination revealed that the tumor consisted of mature teratoma and yolk sac tumor.
  • He underwent 1 course of chemotherapy post-operatively because a small number of viable cells were histopathologically recognized in the yolk sac component.
  • At the time of writing, the patient is alive without any evidence of recurrence.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Endodermal Sinus Tumor / drug therapy. Endodermal Sinus Tumor / surgery. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / surgery. Neoplasms, Multiple Primary. Teratoma / drug therapy. Teratoma / surgery
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Humans. Male. Perioperative Care. Treatment Outcome

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  • (PMID = 14978917.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin
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11. Kurata A, Hirano K, Nagane M, Fujioka Y: Immature teratoma of the ovary with distant metastases: favorable prognosis and insights into chemotherapeutic retroconversion. Int J Gynecol Pathol; 2010 Sep;29(5):438-44
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  • [Title] Immature teratoma of the ovary with distant metastases: favorable prognosis and insights into chemotherapeutic retroconversion.
  • We present a case of a young woman with an immature teratoma of the right ovary that showed systemic metastases.
  • Pathologic diagnosis was an immature teratoma, grade 2.
  • As brain, lung, and liver metastases were discovered within 2 years after the operation, sequential resections of the metastatic foci were performed before chemotherapy as well as during the early and late stages of chemotherapy.
  • The resected specimens of each metastatic focus contained histologically more mature elements of the primary immature teratoma and exhibited a decrease in the Ki-67 labeling index, the later the resection was performed.
  • As far as we know, this is the first case of brain metastasis stemming from an immature teratoma of the ovary.
  • In addition, it was highly suggestive that chemotherapy itself was the main etiological factor for the promotion of maturation.
  • [MeSH-major] Ovarian Neoplasms / pathology. Teratoma / secondary
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Brain Neoplasms / drug therapy. Brain Neoplasms / secondary. Brain Neoplasms / surgery. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Prognosis. Treatment Outcome

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  • (PMID = 20736769.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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12. Fan Q, Huang H, Lian L: [The characteristics diagnosis and treatment of hepatic metastasis of simple immature ovarian teratoma]. Zhonghua Fu Chan Ke Za Zhi; 2000 Oct;35(10):613-6
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  • [Title] [The characteristics diagnosis and treatment of hepatic metastasis of simple immature ovarian teratoma].
  • OBJECTIVE: To analyze the characteristics of hepatic metastasis of pure immature ovarian teratoma and explore proper diagnosis and treatment.
  • METHODS: A total of 18 cases with hepatic metastasis of pure immature ovarian teratoma were involved in this study.
  • The clinical stage, operation, chemotherapy and histopathology of primary and secondary tumor as well as the data of long term follow-up were analyzed retrospectively.
  • The hepatic metastatic rate was 16.7% (3/18) in standard adjuvant chemotherapy group but increased obviously to 31.2% (15/48) in irregular chemotherapy group.
  • The surgical resection rate of hepatic metastasis of pure immature ovarian teratoma was 94.4% (17/18).
  • The follow-up time ranged from 3-205 months with the mean of 20.9 months.
  • CONCLUSIONS: The hepatic metastatic rate of pure immature ovarian teratoma could be decreased by using standard adjuvant chemotherapy.
  • Suitable surgical treatment could reduce complication and improve the prognosis of this kind of patients.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / diagnosis. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology. Teratoma / diagnosis

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  • (PMID = 11372414.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Cöl C: Immature teratoma in both mediastinum and liver of a 21-Year-old female patient. Acta Med Austriaca; 2003;30(1):26-8
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  • [Title] Immature teratoma in both mediastinum and liver of a 21-Year-old female patient.
  • We present a case of an immature teratoma of the liver and the mediastinum.
  • Computed tomography (CT) also showed a big mass which contained multiple high density, nodular, semi-solid, heterogenic structures in the liver and another mass which contained multiple low density cystic lesions in the anterior mediastinum.
  • The mediastinal tumour extended to the diaphragm on the right side, and is dissected from the 'surrounding lung, pericardium' and excised from diaphragm.
  • Intraoperative frozen sections of the liver tumor revealed teratoma.
  • But the final pathological diagnosis was immature teratoma.
  • Chemotherapy was given after surgery.
  • The patient tolerated the procedure well and her postoperative course was unremarkable.
  • [MeSH-major] Liver Neoplasms / pathology. Liver Neoplasms / surgery. Teratoma / pathology. Teratoma / surgery
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Biopsy, Needle. Combined Modality Therapy. Female. Humans. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 12558563.001).
  • [ISSN] 0303-8173
  • [Journal-full-title] Acta medica Austriaca
  • [ISO-abbreviation] Acta Med. Austriaca
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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14. Amin RM, Kokubo T, Hiroshima K, Narita M, Itou K, Kuroki M, Tanizawa T, Nakatani Y: Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma. Pathol Int; 2005 Oct;55(10):649-54
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  • [Title] Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma.
  • Two years after testicular resection was carried out in a 40-year-old man that revealed mixed germ cell tumor of more than one histological type (seminoma, embryonal cell carcinoma, and yolk sac tumor), he presented with an asymptomatic pulmonary nodule in his left lower lobe.
  • Video-assisted thoracoscopic partial resection of the tumor revealed a 24 x 20 mm teratoma with somatic-type malignancy in which pleomorphic rhabdomyosarcoma was a major element.
  • Throughout the course there was no abdominal lymph node swelling detected by computed tomography (CT) and tumor markers were normal.
  • Adjuvant chemotherapy was started after the tumor recurrence.
  • Currently, the patient is still undergoing chemotherapy 5 months after the tumor recurrence.
  • In conclusion, despite the fact that primary pulmonary rhabdromyosarcoma is a rare neoplasm, metastatic pulmonary germ cell tumor with somatic-type malignancy showing predominantly rhabdomyosarcomatous differentiation should be considered in the differential diagnosis of such lesions of the lung.
  • [MeSH-major] Lung Neoplasms / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Rhabdomyosarcoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Male. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 16185296.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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15. Grushka JR, Ryckman J, Mueller C, Roessingh Ade B, Walton JM, St Vil D, Laberge JM, Bernard C, Nguyen VH, Puligandla PS: Spindle epithelial tumor with thymus-like elements of the thyroid: a multi-institutional case series and review of the literature. J Pediatr Surg; 2009 May;44(5):944-8
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  • The diagnosis of SETTLE was confirmed at the time of the initial operation in 2 of the 3 patients.
  • One patient presented 10 years after resection with shortness of breath and hemoptysis secondary to multiple bilateral parenchymal lung metastases.
  • This patient received chemotherapy against the epithelial components of the tumor with a 25% response based on imaging studies.
  • However, chemotherapy against specific tumor elements is only marginally effective.
  • [MeSH-minor] Abscess / diagnosis. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Celecoxib. Child. Child, Preschool. Cisplatin / administration & dosage. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Diagnostic Errors. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Humans. Ifosfamide / administration & dosage. Lung Neoplasms / drug therapy. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Male. Pyrazoles / administration & dosage. Sulfonamides / administration & dosage. Teratoma / pathology. Thalidomide / administration & dosage. Thyroidectomy

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  • (PMID = 19433175.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Multicenter Study; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Pyrazoles; 0 / Sulfonamides; 0W860991D6 / Deoxycytidine; 4Z8R6ORS6L / Thalidomide; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; B76N6SBZ8R / gemcitabine; JCX84Q7J1L / Celecoxib; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
  • [Number-of-references] 20
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16. Sarkar S, Kundu AK, Chakrabarti S: Lungs: victim of synchronous double malignancies. J Assoc Physicians India; 2007 Mar;55:235-7
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  • A 20 year young man was referred to our institution with superior vena cava (SVC) syndrome, multiple lung opacities and a mass lesion in the right upper zone (RUZ).
  • CT-guided FNAC from the mass lesion was consistent with the diagnosis of non-small cell lung carcinoma (NSCLC).
  • Both FNAC and excisional biopsy of the testicular mass confirmed the diagnosis of immature teratoma with choriocarcinoma, a form of non-seminomatous germ cell tumour (NSGCT).
  • With chemotherapy all metastatic lesions of lung and SVC syndrome disappeared, and the tumour-marker levels decreased.
  • However, the opacity in RUZ progessed to involve right recurrent laryngeal nerve at thoracic inlet, metastasized to the brain, and the patient expired after 4th cycle of chemotherapy.
  • [MeSH-major] Choriocarcinoma / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Teratoma / diagnosis

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  • (PMID = 17598338.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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17. Waterston A, Seywright M, White J: A salutary tale of mistaken identity in testicular cancer. Urol Oncol; 2006 Sep-Oct;24(5):407-9
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  • A 26-year-old patient underwent an orchidectomy for mature teratoma; however, as he had abdominal lymphadenopathy, he was treated with 2 cycles of chemotherapy followed by retroperitoneal lymph node dissection.
  • The abdominal histology revealed mature teratoma and he remained on intense surveillance.
  • Three years later, computerized tomography (CT) indicated he had lung lesions and left hilar lymphadenopathy and, despite normal tumor markers, he was thought to have relapsed.
  • He was treated with 2 cycles of second-line chemotherapy but there was no change in the lung lesions.
  • In the Mayo series, they concluded there was a strong association between sarcoidosis and teratoma but cautioned against a causal relationship as both diseases are rare and found in the same age group.
  • This case report reminds us to always consider the differential diagnoses, particularly if the imaging does not fit the rest of the clinical picture, and when in doubt obtain histology prior to treatment.
  • [MeSH-major] Lung Diseases / diagnosis. Lung Neoplasms / diagnosis. Sarcoidosis / diagnosis. Teratoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Lymph Node Excision. Male


18. Barton SJ, Ashdown DA, Ganta S, Wallace D: An unusual presentation of metastatic testicular tumour. J R Army Med Corps; 2005 Mar;151(1):30-3
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  • We report a unique case of metastatic malignant teratoma from an undescended testis which presented with acute pulmonary embolism.
  • After chemotherapy, the undescended right testicle was resected along with a cord of non- obstructing inferior venal caval tumour which extended into the right atrium with tumour floating free within the atrium at the end of the cord of tumour.
  • The presentation, diagnosis and treatment of testicular tumours is described and the literature pertaining to testicular tumours in military personnel reviewed.
  • [MeSH-major] Carcinoma, Embryonal / diagnosis. Pulmonary Embolism / diagnosis. Pulmonary Embolism / etiology. Teratoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Male. Military Personnel. Neoplastic Cells, Circulating. Vascular Neoplasms / diagnosis. Vascular Neoplasms / secondary. Vascular Neoplasms / surgery. Vena Cava, Inferior / pathology. Venous Thrombosis / diagnosis. Venous Thrombosis / surgery

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  • (PMID = 15912681.001).
  • [ISSN] 0035-8665
  • [Journal-full-title] Journal of the Royal Army Medical Corps
  • [ISO-abbreviation] J R Army Med Corps
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Michael H, Lucia J, Foster RS, Ulbright TM: The pathology of late recurrence of testicular germ cell tumors. Am J Surg Pathol; 2000 Feb;24(2):257-73
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  • A total of 91 men had histologically documented late recurrences of testicular germ cell tumors characterized by a complete response to treatment with a subsequent disease-free interval of at least 2 years and no evidence of a second primary lesion.
  • Ninety percent of the patients for whom information was available received chemotherapy shortly after their initial diagnosis of testicular germ cell tumors; most of the other patients were known to have stage I disease initially.
  • Overall, 60% of patients had teratoma in their late recurrences, including 20 patients (22%) in whom teratoma was the only element.
  • Thus, teratoma was the most common type of neoplasm in late recurrences.
  • Excluding teratoma coexisting with other types of neoplasms, yolk sac tumor was the most frequent type of tumor in patients with late recurrence.
  • It occurred in 47% of patients, either alone or with teratoma, another nonteratomatous germ cell tumor type, or a "nongerm cell malignant tumor."
  • Unusual types of yolk sac tumor, including glandular, parietal, clear cell, and pleomorphic patterns, were seen frequently in late recurrences and often raised differential diagnostic problems with "nongerm cell" carcinomas.
  • A smaller number of late recurrences consisted of other types of neoplasms.
  • "Nongerm cell malignant tumors," including both sarcomas and carcinomas of various types, occurred in 23% of late-recurrence patients, either alone or with a nonteratomatous germ cell tumor.
  • Late recurrences were seen in many different sites in these patients, including the retroperitoneum, abdomen, pelvis, liver, mediastinum, lung, bone (femur, vertebra, and rib), lymph nodes outside the retroperitoneum and mediastinum (supraclavicular, neck, and axillary regions), scrotum and inguinal regions, adrenal gland, chest wall, and buttocks.
  • Patients whose late recurrences consisted of teratoma only had the most favorable outcomes, with 79% having no evidence of disease at last follow-up.
  • Patients whose late recurrences consisted of pure "nongerm cell malignant tumor" or pure germ cell tumor (yolk sac tumor or other types) had a much worse prognosis: Only 36% to 37% were alive with no evidence of disease.
  • Patients with two different types of nonteratomatous malignancies in their late recurrences had a dismal clinical course: Only 17% with both yolk sac tumor and other nonteratomatous germ cell tumor had no evidence of disease, whereas no patient with both nonteratomatous germ cell tumor and "nongerm cell malignant tumor" was disease free.
  • Late recurrences consisting of teratoma alone often have a favorable outcome, but the prognosis in all other patients is poor.
  • Furthermore, late recurrence is not likely to respond to chemotherapy and is best treated by surgical excision when possible.
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Embryonal / complications. Carcinoma, Embryonal / pathology. Carcinoma, Embryonal / therapy. Choriocarcinoma / complications. Choriocarcinoma / pathology. Choriocarcinoma / therapy. Endodermal Sinus Tumor / complications. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / therapy. Fluorescent Antibody Technique, Direct. Humans. Male. Neoplasm Staging. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Sarcoma / complications. Sarcoma / pathology. Sarcoma / therapy. Seminoma / complications. Seminoma / pathology. Seminoma / therapy. Teratoma / complications. Teratoma / pathology. Teratoma / therapy

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  • (PMID = 10680894.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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20. Salvati M, Piccirilli M, Raco A, Santoro A, Frati R, Lenzi J, Lanzetta G, Agrillo A, Frati A: Brain metastasis from non-seminomatous germ cell tumors of the testis: indications for aggressive treatment. Neurosurg Rev; 2006 Apr;29(2):130-7
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  • [Title] Brain metastasis from non-seminomatous germ cell tumors of the testis: indications for aggressive treatment.
  • All of the patients had undergone surgery plus whole-brain radiotherapy (WBRT), and chemotherapy based on cisplatin.
  • Five patients belonged to radiation therapy oncology group (RTOG) class I; all of them survived.
  • There was a significant difference in survival time between patients in whom the brain metastasis was present at diagnosis (six survivors at 5 years; mean survival 53 months) and patients in whom the brain metastasis occurred during or after chemotherapy (two survivors at 5 years; mean survival 24 months) (P = 0.04).
  • Prognosis is worst in patients with multiple brain metastases, in whom brain involvement occurred during or after cisplatin-based chemotherapy.
  • Considering that these metastases are often both radiosensitive and chemosensitive, and mainly affect young men that are in very good clinical condition, we advocate aggressive treatment with surgery plus adjuvant radiotherapy and chemotherapy.
  • [MeSH-major] Brain Neoplasms / secondary. Neoplasms, Germ Cell and Embryonal / secondary. Teratoma / secondary. Testicular Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Humans. Lung Neoplasms / mortality. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 16328533.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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21. Yanagihara Y, Sawada Y, Ozaw A, Nishid T, Kikugawa T, Ikeda T, Shimamoto K, Aoki K, Tanji N, Iio S, Yokoyam M: [Case report: simultaneous bilateral testicular tumors with different cell types]. Nihon Hinyokika Gakkai Zasshi; 2010 Mar;101(3):574-8
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  • [Title] [Case report: simultaneous bilateral testicular tumors with different cell types].
  • Pathological examination revealed seminoma and immature teratoma in the right testis and seminoma in the left testis.
  • Three months later, computed tomography (CT) showed multiple metastatic lung nodules.
  • In addition, positron emission tomography (PET)-CT examination revealed peri-caval lymph node metastasis together with the lung metastases.
  • Lung metastases disappeared, but the lymph node metastasis reduced and remained after 3 courses of combination chemotherapy with bleomycin, etoposide and cisplatin.
  • PET-CT examination revealed that no uptake of FDG was seen in the lung and lymph nodes.
  • The postoperative course was good and uneventful at 10 months under androgen replacement therapy without disease recurrences.
  • [MeSH-major] Neoplasms, Multiple Primary. Seminoma / diagnosis. Teratoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Androgens / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Diagnostic Imaging. Etoposide / administration & dosage. Hormone Replacement Therapy. Humans. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Lymph Node Excision. Lymphatic Metastasis. Male. Treatment Outcome

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  • (PMID = 20387519.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Androgens; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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22. Berdjis N, Baldauf A, Kittner T, Manseck A, Wirth M: [Paraneoplastic hyperthyroidism in a patient with metastasizing teratocarcinoma and excessively high HCG]. Aktuelle Urol; 2003 Oct;34(6):407-9
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  • [Transliterated title] Paraneoplastische Hyperthyreose bei metastasiertem Teratokarzinom mit exzessiver HCG-Erhöhung.
  • A 40-year-old patient with right testicular cancer (teratoma, embryonal cell carcinoma), diffuse pulmonary metastases and high serum HCG levels presented with symptomatic hyperthyroidism.
  • The patient received immediately thyrostatic therapy and 4 cycles of PEI chemotherapy (Cisplatin, Etoposide, Ifosfamide).
  • Thyroid function had returned to normal by the beginning of the second course of chemotherapy.
  • After right orchiectomy and resection of residual pulmonary masses which revealed vital tumor cells, two additional courses of chemotherapy were performed.
  • The patient is well and without evidence of disease 11 months after therapy.
  • All patients with testicular cancer and excessive HCG production should be evaluated for biochemical and clinical signs of hyperthyroidism and treated accordingly with antithyroidal medication and immediate cytoreductive chemotherapy.
  • [MeSH-major] Chorionic Gonadotropin / blood. Hyperthyroidism / diagnosis. Lung Neoplasms / secondary. Paraneoplastic Syndromes / diagnosis. Teratocarcinoma / secondary. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Antithyroid Agents / therapeutic use. Combined Modality Therapy. Humans. Lymphatic Metastasis. Male. Neoadjuvant Therapy. Orchiectomy. Pneumonectomy. Tomography, X-Ray Computed

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  • (PMID = 14579189.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antithyroid Agents; 0 / Chorionic Gonadotropin
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23. Rana SS, Swami N, Mehta S, Singh J, Biswal S: Intrapulmonary teratoma: an exceptional disease. Ann Thorac Surg; 2007 Mar;83(3):1194-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrapulmonary teratoma: an exceptional disease.
  • Intrathoracic teratomas almost always occur in the mediastinum, but occasionally, they may be found in the lung as intrapulmonary teratomas.
  • Intrapulmonary teratomas have histologic findings that are similar to those of teratoma from other sites.
  • Two successive patients with intrapulmonary teratomas presented to us in a variable manner.
  • [MeSH-major] Lung Neoplasms / pathology. Lung Neoplasms / surgery. Teratoma / pathology. Teratoma / surgery. Thoracic Surgical Procedures
  • [MeSH-minor] Abscess / etiology. Abscess / radiography. Abscess / surgery. Adult. Antitubercular Agents / therapeutic use. Drainage. Female. Humans. Lung Diseases / etiology. Lung Diseases / radiography. Lung Diseases / surgery. Recurrence. Thoracotomy. Tomography, X-Ray Computed. Tuberculosis, Pulmonary / complications. Tuberculosis, Pulmonary / drug therapy

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  • (PMID = 17307495.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antitubercular Agents
  • [Number-of-references] 7
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24. Kang CH, Kim YT, Jheon SH, Sung SW, Kim JH: Surgical treatment of malignant mediastinal nonseminomatous germ cell tumor. Ann Thorac Surg; 2008 Feb;85(2):379-84
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  • [Title] Surgical treatment of malignant mediastinal nonseminomatous germ cell tumor.
  • BACKGROUND: The aim of this study was to evaluate the role of surgical treatment for mediastinal nonseminomatous germ cell tumors (MNSGCT) and identify the factors of long-term survival.
  • Three different regimens were used for preoperative chemotherapy, and 14 patients (66.7%) achieved partial response, 4 (19.0%) had stable disease, and 2 (9.5%) had progressive disease.
  • Concomitantly resected organs were lung in 13 patients (61.9%) and superior vena cava in 5 (23.8%).
  • Viable germ cell tumor was identified in pathology specimens in 12 (57.1%), total necrosis in 7 (33.3%), and remnant teratoma in 2 (9.5%).
  • Risk factors for poor overall survival by multivariate analysis were beta-human chorionic gonadotrophin (beta-HCG) elevation at initial diagnosis (p = 0.02) and incomplete resection (p = 0.002).
  • CONCLUSIONS: Surgical resection of MNSGCT after chemotherapy showed favorable long-term survival.
  • An elevated beta-HCG level at initial diagnosis was associated with a poor prognosis despite multimodality therapy.
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Biopsy, Needle. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Preoperative Care / methods. Probability. Prognosis. Proportional Hazards Models. Registries. Retrospective Studies. Risk Assessment. Survival Analysis. Thoracotomy / methods. Treatment Outcome

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  • (PMID = 18222229.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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25. Wang WP, Guo C, Berney DM, Ulbright TM, Hansel DE, Shen R, Ali T, Epstein JI: Primary carcinoid tumors of the testis: a clinicopathologic study of 29 cases. Am J Surg Pathol; 2010 Apr;34(4):519-24
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  • Nineteen were pure carcinoid tumors, 3 were associated with cystic teratoma, 2 with cysts lacking epithelial lining, 4 with epidermoid cyst, and 1 with dermoid cyst.
  • All 29 primary carcinoids lacked associated intratubular germ cell neoplasia, unclassified type.
  • Of the 28 cases found premortem, treatment included focal excision in 3 patients and radical orchiectomy in 25 patients.
  • Of the 4 patients with a primary atypical carcinoid tumor, 1 at the time of diagnosis had retroperitoneal and lung metastases who after chemotherapy underwent resection of the retroperitoneal tumor showing metastatic yolk sac tumor and embryonal carcinoma.
  • After resection, serum AFP levels remained elevated and the patient is scheduled for salvage chemotherapy and bone marrow transplant.
  • Most primary carcinoid tumors of the testis have a benign clinical course even if associated with epidermoid/dermoid cysts, or histologically mature teratoma.

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  • [ErratumIn] Am J Surg Pathol. 2010 Jul;34(7):1075. Ubright, Thomas M [corrected to Ulbright, Thomas M]
  • (PMID = 20351489.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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26. Tsuji Y, Matsuda H, Hara I, Yoshimura M, Okita Y: Aortic and vena caval reconstruction with retroperitoneal lymph node dissection for metastatic germ cell tumor. Vasa; 2005 May;34(2):140-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Firstly orchiectomy was done obtaining the pathological diagnosis of mixed type germ cell tumor.
  • After cisplatin-based chemotherapy, he underwent resection of the retroperitoneal lymph node involving the abdominal aorta and the inferior vena cava.
  • Two months after the laparotomy, 12 metastatic nodules in the left lung were resected.
  • Seven months later, he furthermore underwent resection of 4 metastatic nodules in the right lung.
  • Microscopically, all resected metastatic tumors were diagnosed to be mature teratoma without viable malignant cells.
  • [MeSH-major] Aorta / surgery. Lymph Nodes / surgery. Neoplasms, Germ Cell and Embryonal / secondary. Neoplasms, Germ Cell and Embryonal / therapy. Testicular Neoplasms / diagnosis. Testicular Neoplasms / therapy. Venae Cavae / surgery
  • [MeSH-minor] Humans. Lymphatic Metastasis. Male. Middle Aged. Peritoneum / pathology. Peritoneum / radiography. Peritoneum / surgery. Reconstructive Surgical Procedures / methods. Treatment Outcome

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  • (PMID = 15968899.001).
  • [ISSN] 0301-1526
  • [Journal-full-title] VASA. Zeitschrift für Gefässkrankheiten
  • [ISO-abbreviation] VASA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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27. Mavinkurve-Groothuis AM, Hoogerbrugge PM, Meijer-Vandenbergh EM, Brouwer HG, van Enk JG: Patient delay due to embarrassment and fear in two adolescents with a malignant tumor. Pediatr Blood Cancer; 2008 May;50(5):1083
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Bone Neoplasms / secondary. Fear / psychology. Psychology, Adolescent. Sarcoma, Ewing / secondary. Teratoma / secondary. Testicular Neoplasms / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adolescent. Fatal Outcome. Female. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Lymphatic Metastasis. Male. Patient Acceptance of Health Care / psychology. Retroperitoneal Neoplasms / drug therapy. Retroperitoneal Neoplasms / psychology. Retroperitoneal Neoplasms / secondary






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