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1. Chia WK, Ong S, Toh HC, Hee SW, Choo SP, Poon DY, Tay MH, Tan CK, Koo WH, Foo KF: Phase II trial of gemcitabine in combination with cisplatin in inoperable or advanced hepatocellular carcinoma. Ann Acad Med Singapore; 2008 Jul;37(7):554-8
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  • [Title] Phase II trial of gemcitabine in combination with cisplatin in inoperable or advanced hepatocellular carcinoma.
  • INTRODUCTION: Advanced hepatocellular carcinoma (HCC) has a dismal prognosis and is notoriously chemo-resistant.
  • We conducted a Phase II prospective study to evaluate the activity and tolerability of gemcitabine and cisplatin in chemo-naïve advanced hepatocellular carcinoma.
  • Utilising a Simon's minimax two-stage design with a type I error of 0.05 and power of 80%, 25 subjects would be required.
  • Fifteen patients would be needed in stage 1 and if fewer than 2 responses were observed, the trial would be stopped and lack of efficacy claimed.
  • Assessment of response based on computer tomography was performed after every 2 cycles of chemotherapy.
  • This regime was well tolerated and there was only 1 patient who experienced grade IV toxicities.
  • A further 3 patients experienced stable disease and 11 patients progressed on chemotherapy.
  • The median time to progression was 6 weeks.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Liver Neoplasms / drug therapy
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Disease-Free Survival. Female. Humans. Male. Middle Aged. Prospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 18695766.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
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2. Huang GW, Yang LY: Metallothionein expression in hepatocellular carcinoma. World J Gastroenterol; 2002 Aug;8(4):650-3
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  • [Title] Metallothionein expression in hepatocellular carcinoma.
  • AIM: To investigate the expression of metallothioneins (MTs), which were recently thought to have close relationship with tumors, in human hepatocellular carcinoma.
  • METHODS: Histological specimens of 35 cases of primary human hepatocellular carcinoma with para-neoplastic liver tissue and 5 cases of normal liver were stained for MTs with monoclonal mouse anti-MTs serum (E9) by the immunohistochemical ABC technique.
  • But MTs were stained strongly positive in all the five cases of normal liver and 35 cases of para-neoplastic liver tissue.
  • The differences of MTs expression between HCC and normal liver tissue or para-neoplastic liver tissue were highly significant (P<0.01).
  • The rate of MTs expression in HCC grade I was 100 percent, higher than that in grade II(81 %) and grade III and IV (78 %).
  • No obvious correlations between MTs expression in HCC and tumor size, clinical stage or serum alpha fetoprotein concentration were found (P>0.05).
  • We can choose the anticancer agents according to the MTs concentration in HCC, which may improve the results of chemotherapy for HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / enzymology. Liver Neoplasms / enzymology. Metallothionein / metabolism

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  • (PMID = 12174372.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 9038-94-2 / Metallothionein
  • [Other-IDs] NLM/ PMC4656314
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3. Parikh PM, Fuloria J, Babu G, Doval DC, Awasthy BS, Pai VR, Prabhakaran PS, Benson AB: A phase II study of gemcitabine and cisplatin in patients with advanced hepatocellular carcinoma. Trop Gastroenterol; 2005 Jul-Sep;26(3):115-8
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  • [Title] A phase II study of gemcitabine and cisplatin in patients with advanced hepatocellular carcinoma.
  • The primary objective of this study was to determine the response rates of a combination of gemcitabine and cisplatin in unresectable hepatocellular carcinoma (HCC) in Indian patients.
  • The secondary objectives were to evaluate the toxicity, time to progressive disease and overall survival for this combination.
  • Chemonaive patients with histopathologically proven, bidimensionally measurable, stage Ill or IV unresectable HCC were enrolled into this study.
  • Response assessment was done by a Computed Tomography scan after every two cycles of chemotherapy.
  • The median time to progression was 18 weeks (range 1 to 74 weeks) and the median duration of response was 13 weeks (range 4 to 68 weeks).
  • There is a need to further evaluate this combination in order to define its role in the treatment of HCC.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Hepatocellular / drug therapy. Cisplatin / administration & dosage. Deoxycytidine / analogs & derivatives. Liver Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Drug Therapy, Combination. Female. Humans. Male. Middle Aged. Survival Rate. Treatment Outcome

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  • (PMID = 16512457.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
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4. Lin AY, Fisher GA, So S, Tang C, Levitt L: Phase II study of imatinib in unresectable hepatocellular carcinoma. Am J Clin Oncol; 2008 Feb;31(1):84-8
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  • [Title] Phase II study of imatinib in unresectable hepatocellular carcinoma.
  • BACKGROUND: The expression of platelet-derived growth factor, a potent mitogen, and its receptor both in tissue and serum correlate with the severity of liver cirrhosis.
  • Over-expression of platelet-derived growth factor has been demonstrated in human hepatocellular carcinoma (HCC) tumors and cell lines.
  • Metastatic disease (American Joint Committee on Cancer stage IV) was noted in 13 patients and locally advanced (stage III) in the remainder.
  • Two patients had grade 3 elevated liver function tests during treatment; otherwise, there was no other grade 3 or 4 nonhematologic toxicity noted.
  • CONCLUSION: Although toxicities were tolerable, imatinib as a monotherapy for the treatment of unresectable HCC has little, if any, significant efficacy.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Liver Neoplasms / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Benzamides. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Bone Neoplasms / surgery. Female. Heart Neoplasms / drug therapy. Heart Neoplasms / secondary. Heart Neoplasms / surgery. Humans. Imatinib Mesylate. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Male. Middle Aged. Prognosis. Protein-Tyrosine Kinases / antagonists & inhibitors. Survival Rate. Treatment Outcome

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  • (PMID = 18376233.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Protein-Tyrosine Kinases
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5. Schöniger-Hekele M, Müller C, Kutilek M, Oesterreicher C, Ferenci P, Gangl A: Hepatocellular carcinoma in Austria: aetiological and clinical characteristics at presentation. Eur J Gastroenterol Hepatol; 2000 Aug;12(8):941-8
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  • [Title] Hepatocellular carcinoma in Austria: aetiological and clinical characteristics at presentation.
  • BACKGROUND AND AIMS: The aetiology of chronic liver disease leading to hepatocellular carcinoma (HCC) and the clinical characteristics at the time of presentation vary considerably among different parts of the world and over time.
  • We investigated baseline characteristics of patients with hepatocellular carcinoma such as cirrhosis, hepatitis virus markers, age at presentation and stage of the tumour in an area with low prevalence of viral hepatitis.
  • RESULTS: The median age at detection of HCC was 63.3 years, and alcoholic liver disease (35.1%) and hepatitis C virus (HCV) infection (36.7%) were the most frequent underlying diseases.
  • At the time of diagnosis, 43.5% had multi-nodular tumours.
  • Most of our patients presented at a late stage of the disease (TNM stage 3 29.4%, TNM stage 4 69.7%; Okuda stage 2 65.7%, Okuda stage 3 18.0%).
  • Due to the late stage of the disease at the time of presentation, 145 patients (59.2%) received palliative care only, 24 (9.8%) underwent liver resection, 38 (15.5%) liver transplantation and 38 (15.5%) chemotherapy.
  • This resulted in a high percentage of patients who received palliative care only and very few who were eligible for treatment modalities with curative potential such as resection and liver transplantation.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / etiology. Liver Cirrhosis / complications. Liver Cirrhosis / diagnosis. Liver Neoplasms / diagnosis. Liver Neoplasms / etiology

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  • (PMID = 10958223.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
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6. Tanisaka Y, Seike H, Matsumoto T, Tanaka Y, Tsubouchi E, Miyauchi S, Iwakawa K, Ichikawa M: [A case of advanced hepatocarcinoma responding to combination therapy of S-1 and PEG-IFN]. Gan To Kagaku Ryoho; 2009 Oct;36(10):1761-3
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  • [Title] [A case of advanced hepatocarcinoma responding to combination therapy of S-1 and PEG-IFN].
  • Results of close examination revealed stage IV B with bone metastases, and pulmonary metastases was diagnosed.
  • After consultation, whole-body chemotherapy combining S-1 and PEG-IFN was attempted as of June 26, 2007.
  • S-1 (80 mg/day) was then administered every day for two weeks with drug withdrawal for one week.
  • The therapeutic effectiveness of this chemotherapy was confirmed by imaging test.
  • The course was favorable, and whole-body chemotherapy was discontinued on January 29, 2008.
  • This treatment method is a promising choice for whole-body chemotherapy for advanced hepatocarcinoma in the future.
  • We have added some review of the literature, and the S-1+PEG-IFN combination chemotherapy is reported.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Interferon-alpha / therapeutic use. Liver Neoplasms / drug therapy. Oxonic Acid / therapeutic use. Polyethylene Glycols / therapeutic use. Tegafur / therapeutic use
  • [MeSH-minor] Angiography. Bone Neoplasms / drug therapy. Bone Neoplasms / radiography. Bone Neoplasms / secondary. Drug Combinations. Hepatitis C, Chronic / complications. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Staging. Recombinant Proteins. Tomography, X-Ray Computed

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  • (PMID = 19838044.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Combinations; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2a; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 30IQX730WE / Polyethylene Glycols; 5VT6420TIG / Oxonic Acid; 76543-88-9 / interferon alfa-2a
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7. Sumie S, Yamashita F, Ando E, Tanaka M, Yano Y, Fukumori K, Sata M: Interventional radiology for advanced hepatocellular carcinoma: comparison of hepatic artery infusion chemotherapy and transcatheter arterial lipiodol chemoembolization. AJR Am J Roentgenol; 2003 Nov;181(5):1327-34
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  • [Title] Interventional radiology for advanced hepatocellular carcinoma: comparison of hepatic artery infusion chemotherapy and transcatheter arterial lipiodol chemoembolization.
  • OBJECTIVE: The prognosis of advanced hepatocellular carcinoma remains poor.
  • The aim of this study was to compare the efficacy of hepatic artery infusion chemotherapy and transcatheter arterial Lipiodol chemoembolization for treatment of advanced tumor.
  • Thirty-seven patients with hepatocellular carcinoma and unresectable tumors were enrolled.
  • In the hepatic artery infusion chemotherapy group (n = 16), cisplatin (10 mg/person, on days 1-5) and subsequent 5-fluorouracil (250 mg/person, on days 1-5) were administered for four serial courses.
  • RESULTS: The tumor response rates (complete response plus partial response for all cases) of the hepatic artery infusion chemotherapy and transcatheter arterial Lipiodol chemoembolization groups were 56.3% and 23.8%, respectively, showing the significantly higher rate in the former than in the latter group.
  • The cumulative survival rates between the two groups were not significantly different; whereas in those patients whose tumors were classified as TNM stage IV or as having the maximal tumor size of greater than 5 cm, patients tended to have higher survival rates in the hepatic artery infusion chemotherapy group than in the transcatheter arterial Lipiodol chemoembolization group.
  • Patients' adverse reactions were successfully managed by treatment of symptoms.
  • CONCLUSION: Hepatic artery infusion chemotherapy had a better antitumor effect than transcatheter arterial Lipiodol chemoembolization and may be a useful therapeutic option for more advanced hepatocellular carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Hepatocellular / therapy. Chemoembolization, Therapeutic. Liver Neoplasms / therapy. Radiography, Interventional
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Cisplatin / administration & dosage. Drug Administration Schedule. Epirubicin / administration & dosage. Female. Fluorouracil / administration & dosage. Hepatic Artery. Humans. Infusions, Intra-Arterial. Iodized Oil / administration & dosage. Male. Middle Aged. Statistics, Nonparametric. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 14573429.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3Z8479ZZ5X / Epirubicin; 8001-40-9 / Iodized Oil; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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8. Gervain J: [Symptoms of hepatocellular carcinoma. Laboratory tests used for its diagnosis and screening]. Orv Hetil; 2010 Aug 29;151(35):1415-7
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  • [Title] [Symptoms of hepatocellular carcinoma. Laboratory tests used for its diagnosis and screening].
  • [Transliterated title] A hepatocellularis carcinoma tünetei. A diagnosztika és a szurés laboratóriumi vizsgálatai.
  • Early stage hepatocellular carcinoma is a symptom-free disease.
  • Local and general symptoms occur due to the growth of the tumor tissue and the infiltration of the surrounding blood vessels.
  • Illness progression is indicated by the development of abdominal discomfort, cachexia, therapy-resistant decompensation of previously compensated cirrhosis and in severe cases, the thrombosis of the portal vein or the hepatic veins.
  • To clarify the etiology and to identify high risk patients, we need to differentiate alcohol-, drug- or chemical-induced hepatic disorders, viral hepatitis B, C and Delta, metabolic disorders and non-alcoholic steatohepatitis.
  • Other, less commonly measured biomarkers are the glycosilated alfa fetoprotein-L3 and the vitamin K-deficiency induced des-gamma-carboxy prothrombin.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / prevention & control. Liver Neoplasms / diagnosis. Liver Neoplasms / prevention & control. Mass Screening / methods
  • [MeSH-minor] Alcohol Drinking / adverse effects. Biomarkers / blood. Drug-Induced Liver Injury / complications. Early Detection of Cancer. Fatty Liver / complications. Hepatitis, Viral, Human / complications. Humans. Protein Precursors / blood. Prothrombin. alpha-Fetoproteins / metabolism

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  • (PMID = 20719715.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Protein Precursors; 0 / alpha-Fetoproteins; 53230-14-1 / acarboxyprothrombin; 9001-26-7 / Prothrombin
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9. Kamiyama T, Nakagawa T, Nakanishi K, Kurauchi N, Kamachi H, Matsushita M, Todo S: [Postoperative adjuvant intraarterial chemotherapy of combined cisplatin and 5-FU for advanced hepatocellular carcinoma]. Gan To Kagaku Ryoho; 2003 Oct;30(11):1618-20
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  • [Title] [Postoperative adjuvant intraarterial chemotherapy of combined cisplatin and 5-FU for advanced hepatocellular carcinoma].
  • Postoperative adjuvant intraarterial infusion chemotherapy was performed for 22 hepatectomized patients with Stage III and Stage IV-A hepatocellular carcinoma from July, 1997, to December, 1999.
  • One course of this chemotherapy consisted of cisplatin (10 mg/body/day on days 1-5) followed by 5-FU (250 mg/body/day on days 1-5).
  • One hundred forty-eight patients of Stage III and Stage IV-A underwent hepatectomy from 1992 to 2001 and were enrolled as historical control.
  • There were 9 Stage III cases treated with this adjuvant chemotherapy, and there were 7 or 6 Stage IV-A cases with and without main portal thrombosis, respectively.
  • Survival and disease-free survival curves were not improved compared to historical control by this adjuvant chemotherapy.
  • The number of recurrences in the remnant liver of 2 Stage IV-A cases with main portal thrombosis was limited to 3.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Hepatectomy. Liver Neoplasms / drug therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Fluorouracil / administration & dosage. Humans. Infusions, Intra-Arterial. Neoplasm Staging. Postoperative Care. Prognosis

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  • (PMID = 14619478.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; CF regimen
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10. Bhagat V, Javle M, Yu J, Agrawal A, Gibbs JF, Kuvshinoff B, Nava E, Iyer R: Combined hepatocholangiocarcinoma: case-series and review of literature. Int J Gastrointest Cancer; 2006;37(1):27-34
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  • BACKGROUND AND AIM: Combined hepatocholangiocarcinoma (CHCC) is an infrequent primary hepatic malignancy with no clearly defined diagnostic criteria, poorly studied natural history, and no guidelines regarding therapy.
  • Early TNM stage (I and II) compared with advanced disease (III and IV) correlated with higher overall survival on univariate analyses [37 and 6 mo respectively (p = 0.011)].
  • Median overall survival was significantly higher in patients who underwent potentially curative resection (23 mo, range 4-48+) compared with patients who underwent non-surgical therapies such as transcatheter arterial chemoembolization and chemotherapy (2 mo, range 1-8) (p = 0.0357, one-sided exact log-rank test).
  • Surgical resection and early stage at diagnosis predict longer survival.
  • [MeSH-major] Carcinoma, Hepatocellular / complications. Cholangiocarcinoma / complications. Liver Neoplasms / complications

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  • (PMID = 17290078.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
  • [Number-of-references] 37
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11. Homma H, Mezawa S, Doi T, Miyanishi K, Takada K, Kukitsu T, Oku T, Masuko E, Nojiri S, Niitsu Y: A comparative randomized trial of intermittent intrahepatic arterial carboplatin- versus doxorubicin-lipiodol emulsion in advanced hepatocellular carcinoma (stage IV). Hepatogastroenterology; 2004 Jul-Aug;51(58):1135-9
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  • [Title] A comparative randomized trial of intermittent intrahepatic arterial carboplatin- versus doxorubicin-lipiodol emulsion in advanced hepatocellular carcinoma (stage IV).
  • BACKGROUND/AIMS: The study was performed to investigate the anti-tumor effect, survival rate, and toxicity of intermittent intrahepatic infusion chemotherapy with carboplatin suspended in lipiodol.
  • METHODOLOGY: We conducted a randomized controlled study containing either doxorubicin or carboplatin in 65 patients with advanced hepatocellular carcinoma.
  • Therefore, carboplatin is effective and preferable for repeated intrahepatic arterial administration to treat advanced hepatocellular carcinoma over a relatively long period.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Agents / administration & dosage. Carboplatin / administration & dosage. Carcinoma, Hepatocellular / drug therapy. Doxorubicin / administration & dosage. Liver Neoplasms / drug therapy
  • [MeSH-minor] Aged. Dose-Response Relationship, Drug. Drug Administration Schedule. Drug Combinations. Emulsions. Female. Humans. Infusions, Intra-Arterial. Iodized Oil / administration & dosage. Male. Middle Aged. Neoplasm Staging. Survival Analysis. Treatment Outcome

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  • (PMID = 15239261.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 0 / Drug Combinations; 0 / Emulsions; 8001-40-9 / Iodized Oil; 80168379AG / Doxorubicin; BG3F62OND5 / Carboplatin
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12. Shimoda M, Ghobrial RM, Carmody IC, Anselmo DM, Farmer DG, Yersiz H, Chen P, Dawson S, Durazo F, Han S, Goldstein LI, Saab S, Hiatt J, Busuttil RW: Predictors of survival after liver transplantation for hepatocellular carcinoma associated with Hepatitis C. Liver Transpl; 2004 Dec;10(12):1478-86
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  • [Title] Predictors of survival after liver transplantation for hepatocellular carcinoma associated with Hepatitis C.
  • The efficacy of orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) is not well defined.
  • Univariate and multivariate analyses considered the following variables: gender, pTNM stage, tumor size, number of nodules, vascular invasion, incidental tumors, adjuvant chemotherapy, preoperative chemoembolization, alpha-fetoprotein (AFP) tumor marker, lobar distribution, and histological grade.
  • Overall survival of patients with stage I HCC was significantly better than patients with stage II, III, or IV (P < .05).
  • Eleven of 67 patients developed tumor recurrence.
  • Twenty-four of 67 patients (36%) died during the follow-up time.
  • Both univariate and multivariate analysis demonstrated that pTNM status (I versus II, III, and IV; P < .05) was a reliable prognostic indicator for patient survival.
  • Multivariate analysis showed that pretransplant chemoembolization and adjuvant chemotherapy reduced risk of death after OLT in HCC recipients.
  • Advanced tumor stage, and particularly vascular invasion, are poor prognostic indicators for tumor recurrence.
  • Early pTNM stage, adjuvant chemotherapy, and preoperative chemoembolization were associated with positive outcomes for patients who underwent OLT for concomitant HCV and HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Carcinoma, Hepatocellular / virology. Hepatitis C / complications. Liver Neoplasms / surgery. Liver Neoplasms / virology. Liver Transplantation
  • [MeSH-minor] Adult. Aged. Blood Vessels / pathology. Cause of Death. Chemoembolization, Therapeutic. Chemotherapy, Adjuvant. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Predictive Value of Tests. Preoperative Care. Prognosis. Risk Factors. Survival Analysis


13. Rizzetto M: Hepatocellular carcinoma: screening and therapy. Minerva Gastroenterol Dietol; 2000 Sep;46(3):143-7
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  • [Title] Hepatocellular carcinoma: screening and therapy.
  • Treatment of the liver cancer (LC) patient is often problematic as the tumour is identified at an advanced stage: the frequent coexistence of cirrhosis limits the use of surgical resection, there is no efficacious chemotherapy, and in patients treatable with liver transplant, indication is rendered uncertain from the point of view of cost-effectiveness and the high risk of recurrence of the tumour and hepatitis infection.
  • Surgical resection appears to be the treatment of choice in patients with a liver tumour in a ''healthy'' liver.
  • Nevertheless, due to the lack of organs palliative treatments, like surgical resection, PEI and TACE are the most indicated in patients with advanced neoplastic disease, in practice patients with TNM III and IV; radiotherapy with protons and the coagulation of the tumour by microwaves or laser fibres are also used in the attempt to slow down the progress of the neoplastic process.
  • In some patients the most effective approach may be the combined use of various therapies, such as TACE, PEI and surgery.

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  • (PMID = 16498375.001).
  • [ISSN] 1121-421X
  • [Journal-full-title] Minerva gastroenterologica e dietologica
  • [ISO-abbreviation] Minerva Gastroenterol Dietol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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14. Zaydfudim V, Whiteside MA, Griffin MR, Feurer ID, Wright JK, Pinson CW: Health insurance status affects staging and influences treatment strategies in patients with hepatocellular carcinoma. Ann Surg Oncol; 2010 Dec;17(12):3104-11
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  • [Title] Health insurance status affects staging and influences treatment strategies in patients with hepatocellular carcinoma.
  • BACKGROUND: Lack of health insurance is associated with poorer outcomes for patients with cancers amenable to early detection.
  • The effect of insurance status on hepatocellular carcinoma (HCC) presentation stage and treatment outcomes has not been examined.
  • We examined the effect of health insurance status on stage of presentation, treatment strategies, and survival in patients with HCC.
  • Logistic, Kaplan-Meier, and Cox models tested the effects of demographic and clinical covariates on the likelihood of having surgical or chemotherapeutic treatments and survival.
  • The uninsured were more likely to present with stage IV disease (P = 0.005).
  • After adjusting for demographics and tumor stage, Medicaid and uninsured patients were less likely to receive surgical treatment (both P < 0.01) but were just as likely to be treated with chemotherapy (P ≥ 0.243).
  • Survival was significantly better in privately insured patients and in those treated with surgery or chemotherapy (all P < 0.01).
  • CONCLUSIONS: Uninsured patients with HCC are more likely to present with late-stage disease.
  • Although insurance status did not affect chemotherapy utilization, Medicaid and uninsured patients were less likely to receive surgical treatment.
  • [MeSH-major] Antineoplastic Agents / economics. Carcinoma, Hepatocellular / economics. Catheter Ablation / economics. Hepatectomy / economics. Insurance, Health. Liver Neoplasms / economics. Liver Transplantation / economics
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Insurance Coverage. Male. Middle Aged. Neoplasm Staging. Registries. Retrospective Studies. Risk Factors. Survival Rate. Treatment Outcome

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  • (PMID = 20585872.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / AHRQ HHS / HS / T32 HS 013833
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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15. Chapman WC, Majella Doyle MB, Stuart JE, Vachharajani N, Crippin JS, Anderson CD, Lowell JA, Shenoy S, Darcy MD, Brown DB: Outcomes of neoadjuvant transarterial chemoembolization to downstage hepatocellular carcinoma before liver transplantation. Ann Surg; 2008 Oct;248(4):617-25
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  • [Title] Outcomes of neoadjuvant transarterial chemoembolization to downstage hepatocellular carcinoma before liver transplantation.
  • PURPOSE: To evaluate outcomes of downstaging patients with advanced (American liver tumor study group stage III/IV) hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) to allow eligibility for orthotopic liver transplant (OLT).
  • Seventy-six (37.6%) patients with stage III/IV HCC were potential transplant candidates if downstaging was achieved by TACE.
  • Seventeen of 76 (22.4%) patients who met other qualifications underwent OLT after successful downstaging (13/38 stage III;4/38 stage IV).
  • CONCLUSION: Selected patients with stage III/IV HCC can be downstaged to Milan criteria with TACE.
  • Importantly, patients who are successfully downstaged and transplanted have excellent midterm disease-free and overall survival, similar to stage II HCC.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Hepatocellular / therapy. Chemoembolization, Therapeutic / methods. Liver Neoplasms / therapy. Liver Transplantation / methods. Neoplasm Staging. Preoperative Care / methods
  • [MeSH-minor] Adult. Dose-Response Relationship, Drug. Follow-Up Studies. Humans. Injections, Intra-Arterial. Neoadjuvant Therapy / methods. Retrospective Studies. Treatment Outcome


16. Lee GY, Kim BS, Seo YT, Choi SH, Kim HJ, Choi DS, Ko JY, Yang SH, Byun JH: Phase II study to topotecan and cisplatin in advanced hepatocellular carcinoma. Korean J Intern Med; 2003 Jun;18(2):104-8
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  • [Title] Phase II study to topotecan and cisplatin in advanced hepatocellular carcinoma.
  • BACKGROUND: Hepatocellular carcinoma remains a highly chemoresistant neoplasm and is a common malignancy with poor prognosis in Korea.
  • We performed a phase II study to evaluate the efficacy and toxicities of topotecan and cisplatin combination chemotherapy for advanced hepatocellular carcinoma.
  • METHODS: Between November 1999 and May 2001, ten patients with histologically proven hepatocellular carcinoma were enrolled in this study.
  • Six patients demonstrated stage IV, 1 stage IIIC, 2 stage IIIB and 1 stage IIIA.
  • The treatment regimen consisted of topotecan 1.25 mg/m2 and cisplatin 20 mg/m2 for 5 days.
  • The treatment was repeated every 4 weeks.
  • But there was no treatment-related death.
  • CONCLUSION: When used in this dose and schedule, topotecan and cisplatin combination chemotherapy does not seem to be effective for patients with advanced hepatocellular carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Cisplatin / administration & dosage. Liver Neoplasms / drug therapy. Topotecan / administration & dosage
  • [MeSH-minor] Aged. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 12872448.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 7M7YKX2N15 / Topotecan; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ PMC4531618
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17. Nakamura H, Kawata S, Takamura M, Osuga K, Murakami T: [Transcatheter arterial embolization for advanced hepatocellular carcinoma--indications and limitations]. Gan To Kagaku Ryoho; 2000 Sep;27(10):1509-15
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  • [Title] [Transcatheter arterial embolization for advanced hepatocellular carcinoma--indications and limitations].
  • Many patients with advanced hepatocellular carcinoma (HCC) in stage IV have no surgical indications.
  • Transcatheter methods such as transcatheter arterial embolization (TAE) and hepatic arterial infusion chemotherapy play a main role of the treatment for advanced HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Embolization, Therapeutic. Liver Neoplasms / therapy

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  • (PMID = 11015994.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 3Z8479ZZ5X / Epirubicin; 8001-40-9 / Iodized Oil; 80168379AG / Doxorubicin
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18. Brůha R, Drastich P, Hůlek P, Lata J, Petrtýl J, Procházka J, Spicák J, Vanásek T, Volfová M, Zdenek P, Portal Hypertension Working Group of the Czech Hepatology Society, J.E. Purkinje Czech Medical Society: [Diagnostics and treatment of hepatocellular carcinoma. Recommendations of the Portal Hypertension Working Group of the Czech Hepatology Society and the J.E. Purkinje Czech Medical Society ]. Vnitr Lek; 2005 Dec;51(12):1406-8
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  • [Title] [Diagnostics and treatment of hepatocellular carcinoma. Recommendations of the Portal Hypertension Working Group of the Czech Hepatology Society and the J.E. Purkinje Czech Medical Society ].
  • Hepatocellular carcionma (HCC) is almost exclusively associated with liver cirrhosis as a significant HCC risk marker in advanced countries.
  • Applicable therapy depends on early diagnosis, and risk patients should be screened for the presence of HCC on a regular basis.
  • There are 3 basic curative therapies for the early stage of HCC: liver transplantation, surgical resection and different methods of local destruction of tumour (i.e., ethanolisation, thermoablation, etc.).
  • Patients at medium stage of HCC may profit from chemoembolisation.
  • Current available systemic chemotherapy is ineffective.
  • Patient survival prognosis after the application of one of the above treatment methods may be similar with that for HCC free cirrhosis patients, however, prognosis for advanced HCC patients is bad, with survival period from one to nine months.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy

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  • (PMID = 16430109.001).
  • [ISSN] 0042-773X
  • [Journal-full-title] Vnitr̆ní lékar̆ství
  • [ISO-abbreviation] Vnitr Lek
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Practice Guideline
  • [Publication-country] Czech Republic
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19. Ochiai T, Sonoyama T, Ikoma H, Kuriu Y, Nakanishi M, Kubota T, Kikuchi S, Ichikawa D, Fujiwara H, Okamoto K, Sakakura C, Kokuba Y, Otsuji E: Salvage surgery for uncontrollable hepatocellular carcinoma treated with repeated non-surgical therapies. Hepatogastroenterology; 2010 Jul-Aug;57(101):858-64
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  • [Title] Salvage surgery for uncontrollable hepatocellular carcinoma treated with repeated non-surgical therapies.
  • BACKGROUND/AIMS: Some hepatocellular carcinoma (HCC) cases undergo surgery because tumor progression cannot be controlled by various non-surgical therapies.
  • METHODOLOGY: Among cases with solitary small HCCs (< or = 3.0cm at the time of detection), the clinicopathologic features of 7 patients who had undergone hepatectomy after various non-surgical therapies (Salvage (S) group) were analyzed and compared with those of 30 patients who received hepatectomy as the initial treatment (Control (C) group).
  • RESULTS: In S group, the serum alpha-fetoprotein level was higher (p = 0.045) and macroscopic ductal invasion was more common (p = 0.028) at the time of the operation.
  • Lobectomy was more commonly performed (p = 0.034) and curability B (No residual cancer, but Stage III or IV) was more frequent (p = 0.011).
  • The survival time after the initial treatment (post-initial treatment survival) was worse (p = 0.028).
  • Univariate analyses revealed that those with maximum tumor sizes of > 3.0 cm at the time of the operation were significantly worse compared with the other patients (p = 0.012).
  • CONCLUSIONS: The timing for changing from a non-surgical treatment to a surgical treatment is important.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hepatectomy. Liver Neoplasms / surgery. Salvage Therapy
  • [MeSH-minor] Aged. Catheter Ablation. Chemoembolization, Therapeutic. Disease Progression. Female. Hepatic Duct, Common / pathology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis. Treatment Failure

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  • (PMID = 21033242.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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20. Knox JJ, Gill S, Synold TW, Biagi JJ, Major P, Feld R, Cripps C, Wainman N, Eisenhauer E, Seymour L: A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepatocellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168). Invest New Drugs; 2008 Jun;26(3):265-72
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  • [Title] A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepatocellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168).
  • Hepatocellular carcinoma (HCC) remains a lethal treatment-resistant cancer with a median survival of <6 months in patients not considered candidates for radical surgical treatments.
  • A non-randomized, non-blinded multicentre two-stage phase II study was completed examining the efficacy, toxicity, and pharmacokinetics of SB-715992 at 18 mg/m2 IV q 3 weeks, in patients with measurable locally advanced, metastatic or recurrent HCC.
  • Seven (46%) patients had a best response of stable disease at the 8-week evaluation (median duration 3.9 months) Median time to progression was 1.61 months (95%CI = 1.31-3.94 months) SB-715992 plasma concentrations were comparable to those observed in the phase I studies.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Benzamides / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Liver Neoplasms / drug therapy. Quinazolines / therapeutic use
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Gene Expression. Humans. Infusions, Intravenous. Kinesin / antagonists & inhibitors. Male. Middle Aged. Neoplasm Metastasis / drug therapy. Treatment Outcome

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  • (PMID = 18196204.001).
  • [ISSN] 0167-6997
  • [Journal-full-title] Investigational new drugs
  • [ISO-abbreviation] Invest New Drugs
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / KIF11 protein, human; 0 / Quinazolines; BKT5F9C2NI / ispinesib; EC 3.6.4.4 / Kinesin
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21. Katzenstein HM, Krailo MD, Malogolowkin MH, Ortega JA, Liu-Mares W, Douglass EC, Feusner JH, Reynolds M, Quinn JJ, Newman K, Finegold MJ, Haas JE, Sensel MG, Castleberry RP, Bowman LC: Hepatocellular carcinoma in children and adolescents: results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study. J Clin Oncol; 2002 Jun 15;20(12):2789-97
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  • [Title] Hepatocellular carcinoma in children and adolescents: results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study.
  • PURPOSE: To determine surgical resectability, event-free survival (EFS), and toxicity in children with hepatocellular carcinoma (HCC) randomized to treatment with either cisplatin (CDDP), vincristine, and fluorouracil (regimen A) or CDDP and continuous-infusion doxorubicin (regimen B).
  • After initial surgery or biopsy, children with stage I (n = 8), stage III (n = 25), and stage IV (n = 13) HCC were randomly assigned to receive regimen A (n = 20) or regimen B (n = 26).
  • Patients with stage I, III, and IV had 5-year EFS estimates of 88% (SD = 12%), 8% (SD = 5%), and 0%, respectively.
  • Events occurred before postinduction surgery I in 18 (47%) of 38 patients with stage III or IV disease, and tumor resection was possible in two (10%) of the remaining 20 children with advanced-stage disease after chemotherapy.
  • CONCLUSION: Children with initially resectable HCC have a good prognosis and may benefit from the use of adjuvant chemotherapy.
  • Outcome was uniformly poor for children with advanced-stage disease treated with either regimen.
  • New therapeutic strategies are needed for the treatment of advanced-stage pediatric HCC.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Carcinoma, Hepatocellular / surgery. Liver Neoplasms / drug therapy. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. Child. Child, Preschool. Cisplatin / administration & dosage. Disease-Free Survival. Doxorubicin / administration & dosage. Female. Fluorouracil / administration & dosage. Humans. Infant. Infant, Newborn. Infusions, Intravenous. Male. Neoplasm Staging. Prognosis. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 12065555.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R25 CA092049
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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22. Ferenci P: Pegylated interferon plus ribavirin for chronic hepatitis C: the role of combination therapy today, tomorrow and in the future. Minerva Gastroenterol Dietol; 2006 Jun;52(2):157-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pegylated interferon plus ribavirin for chronic hepatitis C: the role of combination therapy today, tomorrow and in the future.
  • The majority of those infected with the virus develop chronic progressive liver disease that over time can result in cirrhosis, end-stage liver disease, hepatocellular carcinoma and death.
  • The goal of treatment is viral eradication.
  • The recognised standard of care for chronic hepatitis C is the combination of pegylated interferon plus ribavirin, which has been shown to be effective in treatment-naïve patients, including those with persistently normal ALT levels, and in patients with HIV-HCV coinfection.
  • By far, the most important factors influencing treatment outcomes are HCV genotype and baseline HCV RNA level.
  • Customisation of therapy based on baseline factors is recommended in treatment guidelines in order to maximise cure rates.
  • Ongoing efforts to improve treatment outcomes are focused on dynamic customisation of therapy based on the on-treatment response to therapy.
  • Treatment of nonresponders to previous interferon-based therapies is an important area under investigation.
  • Although several promising oral agents have been identified and are currently in clinical development, it seems likely that pegylated interferon will remain the backbone of therapy for years to come.
  • [MeSH-major] Antiviral Agents / administration & dosage. Hepatitis C, Chronic / drug therapy. Interferon-alpha / therapeutic use. Polyethylene Glycols / therapeutic use. Ribavirin / administration & dosage
  • [MeSH-minor] Drug Therapy, Combination. Forecasting. Humans. Recombinant Proteins

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  • (PMID = 16557187.001).
  • [ISSN] 1121-421X
  • [Journal-full-title] Minerva gastroenterologica e dietologica
  • [ISO-abbreviation] Minerva Gastroenterol Dietol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2a; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 49717AWG6K / Ribavirin; 76543-88-9 / interferon alfa-2a; 99210-65-8 / interferon alfa-2b
  • [Number-of-references] 107
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23. Zhang Z, Fan S: [Liver transplantation for hepatocellular carcinoma: a report of 8 patients]. Zhonghua Wai Ke Za Zhi; 2000 Jun;38(6):415-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Liver transplantation for hepatocellular carcinoma: a report of 8 patients].
  • OBJECTIVE: To evaluate the feasibility of liver transplantation as a treatment for hepatocellular carcinoma (HCC).
  • TNM staging: stage II (5 cases), stage III (2 cases) and stage IV a (1 case).
  • Except for one patient who had preoperative chemotherapy, no anticancer treatment was given before and after transplantation.
  • RESULTS: Three patients had acute rejection, 5 developed complication in early post transplantation.
  • CONCLUSIONS: Liver transplantation is a feasible method for treatment of HCC in selected patients.
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Liver Cirrhosis / complications. Male. Middle Aged. Tissue Donors. Treatment Outcome

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  • (PMID = 11832071.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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24. Kawarada Y, Yamagiwa K: [Up to date of multidisciplinary treatments centering around hepatectomy for advanced liver cancer in stage IV-A]. Gan To Kagaku Ryoho; 2000 Sep;27(10):1489-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Up to date of multidisciplinary treatments centering around hepatectomy for advanced liver cancer in stage IV-A].
  • Patients with advanced Stage IV-A primary liver cancer, hepatocellular carcinoma (HCC) can be divided into subgroups: those with involvement of a major branch of the portal (Vp3) or hepatic (Vv2, Vv3) veins and those having multiple tumors in both lobes without Vp3 or Vv2, Vv3.
  • The prognosis of Stage IV-A patients with Vv2 or Vv3 may be improved by extended hepatectomy with resection and reconstruction of hepatic veins or IVC.
  • In those with Vp3, multidisciplinary treatments consisting of extended hepatectomy and adjuvant chemotherapy, i.e. intra-arterial injection or TACE, are thought to be feasible at the present, but the outcomes are still poor.
  • On the other hand, there are some Stage IV-A patients with multi-centrical tumors who have multiple tumors in both lobes without major vascular invasion, and their prognoses are improved by partial resection of each tumor.
  • However, when there are multiple tumors caused by intrahepatic metastases, multidisciplinary treatments consisting of reduction surgery, microwave ablation, ethanol injection, and intra-arterial chemotherapy might be useful at present.
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Proportional Hazards Models. Survival Rate

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  • (PMID = 11015991.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] JAPAN
  • [Number-of-references] 8
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25. Ishikawa T, Ichida T, Sugitani S, Tsuboi Y, Genda T, Sugahara S, Uehara K, Inayoshi J, Yokoyama J, Ishimoto Y, Asakura H: Improved survival with oral administration of enteric-coated tegafur/uracil for advanced stage IV-A hepatocellular carcinoma. J Gastroenterol Hepatol; 2001 Apr;16(4):452-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improved survival with oral administration of enteric-coated tegafur/uracil for advanced stage IV-A hepatocellular carcinoma.
  • BACKGROUND AND AIMS: There is currently no proven chemotherapy regimen for hepatocellular carcinoma (HCC).
  • The principal chemotherapeutic approach in most cases is infusion therapy into the hepatic arteries feeding the tumors.
  • However, the clinical effects of chemotherapy are extremely poor.
  • METHODS: From 1994 to 1999, a total of 56 consecutive patients with unresectable stage IV-A HCC were studied prospectively to examine the efficacy of enteric-coated tegafur/uracil in HCC and to determine the significant prognostic factors.
  • Twenty-eight patients were treated only with enteric-coated tegafur/uracil without other anticancer treatment.
  • RESULTS: In the group treated only with enteric-coated tegafur/uracil, the median survival time and 1 and 2 year survival rates were 12.13 months and 55.3 and 36.9%, respectively.
  • In the control group, the median survival time and 1 year survival rate were 6.20 months and 5.5%, respectively.
  • By both univariate analysis and multivariate analysis using Cox's proportional hazards model, treatment with enteric-coated tegafur/uracil was shown to be the factor most significantly favoring a better prognosis.
  • CONCLUSIONS: Although the prognosis of most patients with stage IV-A HCC is poor, administration of enteric-coated tegafur/uracil induces long-term survival and is an effective treatment for stage IV-A HCC.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Liver Neoplasms / drug therapy. Tegafur / therapeutic use. Uracil / therapeutic use
  • [MeSH-minor] Administration, Oral. Aged. Drug Combinations. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Survival Analysis. Tablets, Enteric-Coated

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  • [CommentIn] J Gastroenterol Hepatol. 2001 Apr;16(4):361-2 [11354272.001]
  • (PMID = 11354285.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Tablets, Enteric-Coated; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil
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26. Castaldo ET, Pinson CW: Liver transplantation for non-hepatocellular carcinoma malignancy. HPB (Oxford); 2007;9(2):98-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver transplantation for non-hepatocellular carcinoma malignancy.
  • Liver transplantation (LT) for hepatocellular carcinoma is effective for selected patients.
  • For CCA, series that did not emphasize highly selected early stage disease and neoadjuvant or adjuvant chemoradiation had an average 5-year survival of 10%.
  • However, emphasizing neoadjuvant radiation and chemosensitization in operatively confirmed stage I or II hilar CCA has led to improved 5-year survival, up to 82%.
  • LT is indicated under strict research protocols at selected centers, for patients with early stage CCA and anatomically unresectable (Bismuth type IV) lesions.
  • HB is typically sensitive to cisplatin-based chemotherapy.
  • LT plays a role as primary surgical therapy for those individuals in whom tumors remain unresectable after chemotherapy or as rescue therapy for those who are incompletely resected, recur after resection, or develop hepatic insufficiency after chemotherapy and/or resection.

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  • (PMID = 18333123.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2020792
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27. Pham TH, Iqbal CW, Grams JM, Zarroug AE, Wall JC, Ishitani MB, Nagorney DM, Moir C: Outcomes of primary liver cancer in children: an appraisal of experience. J Pediatr Surg; 2007 May;42(5):834-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the most common primary liver cancers in children.
  • Forty-five (87%) received primary or neoadjuvant and/or adjuvant chemotherapy.
  • Patients had the following CCG/POG stages: I (n = 31, 60%), II (n = 6, 11.5%), III (n = 9, 17%), and IV (n = 6, 11.5%).
  • Complete gross resection (stage I and II) was achieved in 37 (71%) patients.
  • CONCLUSION: Complete resection of the pediatric primary liver tumors remains the cornerstone of treatment to achieve cure.
  • Liver transplantation in conjunction with chemotherapy may have an increasing role in the management of locally advanced primary liver cancers.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Hepatoblastoma / therapy. Liver Neoplasms / therapy
  • [MeSH-minor] Adolescent. Analysis of Variance. Child. Child, Preschool. Combined Modality Therapy. Hepatectomy. Humans. Liver Transplantation. Registries. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17502194.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Tanabe G, Ueno S, Maemura M, Kihara K, Aoki D, Yoshidome S, Ogura Y, Hamanoue M, Aikou T: Favorable quality of life after repeat hepatic resection for recurrent hepatocellular carcinoma. Hepatogastroenterology; 2001 Mar-Apr;48(38):506-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Favorable quality of life after repeat hepatic resection for recurrent hepatocellular carcinoma.
  • BACKGROUND/AIMS: The appropriate choice of treatment for recurrent hepatocellular carcinoma after hepatic resection remains controversial.
  • The aim of this study is to clarify prognostic factors and quality of life in patients with tumor recurrence after hepatic resection for hepatocellular carcinoma.
  • METHODOLOGY: We retrospectively analyzed 188 patients with hepatocellular carcinoma who underwent curative hepatic resection between 1988 and 1997.
  • Furthermore, quality of life after treatment for recurrence was compared between patients with repeat hepatic resection or hepatic arterial infusion chemotherapy.
  • RESULTS: In 123 patients with recurrence, unfavorable predictors after recurrence are pTNM Stage III/IV at initial surgery, receiving chemotherapy before initial surgery and presence of extrahepatic recurrence.
  • The incidence of deteriorated performance status in the repeat hepatic resection group was lower than in the hepatic arterial infusion chemotherapy group because of better psychological function in patients undergoing repeat hepatic resection.
  • CONCLUSIONS: Repeat hepatic resection provides a good prognosis and a favorable quality of life in patients with recurrence after hepatic resection for hepatocellular carcinoma.
  • [MeSH-major] Carcinoma, Hepatocellular / surgery. Hepatectomy. Liver Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Quality of Life

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  • (PMID = 11379343.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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