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1. Mizutani K, Seike K, Sugawara T, Masue T, Yokoi S, Ehara H, Takahashi Y, Ishihara S, Deguchi T: [Multiple metastases of the penile cancer: an experience of combination chemotherapy]. Hinyokika Kiyo; 2004 Mar;50(3):223-6
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  • [Title] [Multiple metastases of the penile cancer: an experience of combination chemotherapy].
  • A 49-year-old man with penile cancer (cT3N1M0) was referred to our hospital.
  • The pathologic diagnosis was squamous cell carcinoma.
  • The patient underwent penectomy and bilateral inguinal lymphadenectomy without postoperative adjuvant therapy.
  • Six months later, we found multiple metastases of the penile cancer in the lungs.
  • The patient was then treated with combination chemotherapy of cisplatin, methotrexate, bleomycin.
  • However, the tumors were aggressive and did not respond to the therapy.
  • We discuss the use of combination chemotherapy in the case of advanced penile cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / secondary. Lymph Nodes / pathology. Neoplastic Cells, Circulating / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Bleomycin / administration & dosage. Bone Neoplasms / secondary. Cisplatin / administration & dosage. Drug Administration Schedule. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Male. Methotrexate / administration & dosage. Middle Aged. Penis / surgery

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  • (PMID = 15148780.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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2. Pagliaro LC, Williams DL, Daliani D, Williams MB, Osai W, Kincaid M, Wen S, Thall PF, Pettaway CA: Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol; 2010 Aug 20;28(24):3851-7
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  • [Title] Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study.
  • PURPOSE: Men with penile squamous cell carcinoma and regional lymph node involvement have a low probability of survival with lymphadenectomy alone.
  • A multimodal approach to treatment is desirable for such patients.
  • We performed a phase II study of neoadjuvant chemotherapy with the objective of determining the response rate, time to progression (TTP), and overall survival (OS) among patients with bulky adenopathy.
  • PATIENTS AND METHODS: Eligible patients had stage N2 or N3 (stage III or stage IV) penile cancer without distant metastases.
  • Neoadjuvant treatment (four courses every 3-4 weeks) consisted of paclitaxel 175 mg/m(2) administered over 3 hours on day 1; ifosfamide 1,200 mg/m(2) on days 1 to 3; and cisplatin 25 mg/m(2) on days 1 to 3.
  • RESULTS: Thirty men received chemotherapy of whom 15 (50.0%) had an objective response and 22 (73.3%) subsequently underwent surgery.
  • Improved TTP and OS were significantly associated with a response to chemotherapy (P < .001 and P = .001, respectively), absence of bilateral residual tumor (P = .002 and P = .017, respectively), and absence of extranodal extension (P = .001 and P = .004, respectively) or skin involvement (P = .009 and P = .012, respectively).
  • CONCLUSION: The neoadjuvant regimen of paclitaxel, ifosfamide, and cisplatin induced clinically meaningful responses in patients with bulky regional lymph node metastases from penile cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / secondary. Lymph Node Excision. Neoadjuvant Therapy / methods. Penile Neoplasms / drug therapy. Penile Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Disease-Free Survival. Drug Administration Schedule. Humans. Ifosfamide / administration & dosage. Kaplan-Meier Estimate. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Paclitaxel / administration & dosage. Predictive Value of Tests. Prospective Studies. Radiotherapy, Adjuvant. Risk Factors. Treatment Outcome

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  • (PMID = 20625118.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / P50 CA140388; United States / NCI NIH HHS / CA / CA016672
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
  • [Other-IDs] NLM/ PMC2940402
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3. Berney DM, Stankiewicz E, Adlan AM, Kudahetti S, Biedrzycki OJ, Hadway P, Watkin N, Corbishley C: DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity. BJU Int; 2008 Sep;102(8):1040-4
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  • [Title] DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity.
  • OBJECTIVE: To examine the tissue expression of DNA topoisomerase I (Topo I) and IIalpha (Topo II), to pursue the possibility of future chemotherapy regimens for squamous cell carcinoma of the penis (SCCP), as high expression of Topo I might indicate sensitivity to the camptothecins, whereas high Topo II might indicate sensitivity to etoposide.
  • PATIENTS AND METHODS: In all, 73 patients with SCCP were reviewed and then tissue samples microarrayed.
  • Tumour stage, grade and type were available.
  • Tumour type was also strongly correlated with Topo II and Ki-67 expression, with the highest expression in basaloid carcinomas and the lowest in verrucous carcinomas.
  • CONCLUSION: The expression of Topo I is grade- and type-independent, and chemotherapy using the camptothecins is unlikely to be effective.
  • The strong positivity of Topo II in high-grade and basaloid SCCPs suggests that treatment with etoposide or other Topo II 'poisons' might be a better target for future clinical trials.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / enzymology. DNA Topoisomerases, Type I / metabolism. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / metabolism. Penile Neoplasms / enzymology
  • [MeSH-minor] Drug Resistance, Neoplasm. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male

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  • (PMID = 18489530.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; EC 5.99.1.2 / DNA Topoisomerases, Type I; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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4. Velazquez EF, Barreto JE, Rodriguez I, Piris A, Cubilla AL: Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. Int J Surg Pathol; 2004 Apr;12(2):139-46
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  • [Title] Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma.
  • Surgeons often perform small or superficial penile biopsies that are difficult to classify definitely with regard to a benign or malignant nature, and if malignant, cannot always be accurately subclassified.
  • Staging and therapeutic decisions rely on the identification, in these materials, of pathologic parameters related to prognosis.
  • In this study, we evaluated the accuracy and completeness of pathologic information obtained from biopsies of 57 consecutive patients with squamous cell carcinoma (SSC) of the penis, and compared it with the information obtained from penectomies.
  • The evaluated parameters were as follows: cancer diagnosis, histologic type, tumor grade, depth of invasion (anatomical levels), and vascular invasion.
  • In 2 patients with well-differentiated tumors a diagnosis of cancer could not be established in biopsy material.
  • In 17 cases (30%) there was a biopsy-penectomy discordance of histologic types, especially of verruciform and mixed carcinomas.
  • In summary, biopsies were useful for cancer diagnosis except in 2 differentiated variants of penile squamous cell carcinoma.
  • We conclude that clinical and pathologic staging of penile cancer, at least in our material, cannot depend on biopsy information alone.
  • Data from biopsies may be insufficient to make a decision whether to perform a groin dissection, or for prognostic evaluation in those patients in whom other treatment modalities (such as radiotherapy or chemotherapy) are being considered.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Penile Neoplasms / pathology. Penis / pathology

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  • (PMID = 15173919.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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5. Huilgol NG, Jain A: A new indication of sildenafil in medicine: hypoxic cell sensitizer for penile cancer. J Cancer Res Ther; 2006 Jul-Sep;2(3):132-5
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  • [Title] A new indication of sildenafil in medicine: hypoxic cell sensitizer for penile cancer.
  • PURPOSE: To evaluate the feasibility and results of sildenafil used as radiosensitizer by causing penile vasodilatation and reducing tumor hypoxia in radical radiotherapy for penile cancer.
  • MATERIALS AND METHODS: Three men with histopathologic diagnosis of squamous carcinoma of penis were treated with radical external radiotherapy with concomitant sildenafil.
  • RESULTS: All three patients achieved tumescence, completed the treatment and achieved complete response.
  • One patient had recurrence at 10 months and died of the disease after 23 months from starting the treatment.
  • CONCLUSION: Sildenafil may act as radiosensitizer by causing penile vasodilatation and reducing hypoxia.
  • [MeSH-major] Carcinoma / drug therapy. Cell Hypoxia / drug effects. Penile Neoplasms / drug therapy. Phosphodiesterase Inhibitors / therapeutic use. Piperazines / therapeutic use. Sulfones / therapeutic use
  • [MeSH-minor] Adult. Aged, 80 and over. Combined Modality Therapy. Humans. Male. Middle Aged. Pilot Projects. Purines / therapeutic use. Sildenafil Citrate

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  • (PMID = 17998692.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Phosphodiesterase Inhibitors; 0 / Piperazines; 0 / Purines; 0 / Sulfones; BW9B0ZE037 / Sildenafil Citrate
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6. García Rodríguez J, Fernández Gómez JM, Rodríguez Martínez JJ, Rodríguez Faba O, Jalón Monzón A, San Martín Blanco A, Martínez Gómez FJ, Sánchez Trilla A, Martín Benito JL, Escaf Barmadah S, Regadera Sejas J: [Clinical course of epidermoid carcinoma of the penis in our series]. Arch Esp Urol; 2003 Jan-Feb;56(1):30-6
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  • [Title] [Clinical course of epidermoid carcinoma of the penis in our series].
  • [Transliterated title] Análisis de la evolución del carcinoma epidermoide de pene en nuestra serie.
  • OBJECTIVES: To study the evolution of 49 patients with squamous cell carcinoma of the penis.
  • METHODS: 49 patients who underwent surgery for squamous cell carcinoma of the penis (30 partial penile amputations, 11 total amputations and 7 circumcisions).
  • 27 inguinal lymphadenectomies, superficial, profound and ilio-obturator (2 cases), were performed due to persistent lymph nodes after penile amputation despite of antibiotic treatment for 4 weeks, or to high grade primary tumour.
  • 13 patients were found to have lymph node metastases after treatment, receiving posterior adjuvant treatment with radiotherapy, chemotherapy or a combination of them.
  • Patients were followed in relation to stage, cell differentiation degree, and presence or absence of positive lymph nodes and distant metastases.
  • 6 patients died from tumour dissemination, 2 of them were T2G2, one T2G1, and three T1G2; two additional patients died from causes different from the tumour, all of them being N+ at the time of diagnosis.
  • CONCLUSIONS: Penile squamous cell carcinoma is an aggressive tumour the evolution of which mainly depends on the local-regional stage at the time of diagnosis and cell differentiation; these factors will condition lymphadenectomy versus observation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Penile Neoplasms / pathology. Penile Neoplasms / surgery

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  • (PMID = 12701478.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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7. Buechner SA: Common skin disorders of the penis. BJU Int; 2002 Sep;90(5):498-506
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  • [Title] Common skin disorders of the penis.
  • This review highlights the clinical features, diagnosis and treatment of the most common dermatoses of the male genitalia.
  • The most common causal agents for condyloma acuminatum are low-risk HPV 6 and 11; high-risk HPV types 16 and 18 are associated with premalignant and malignant lesions.
  • Treatment for genital warts remains unsatisfactory; recurrences are common.
  • Imiquimod, a new topical immunotherapeutic agent, which induces interferon and other cytokines, has the potential to be a first-line therapy for genital warts.
  • Scabies and pediculosis are transmitted by skin-to-skin contact and sexual transmission is common, with the penis and scrotum favourite locations for scabious lesions.
  • Oral ivermectin, a highly active antiparasitic drug, is likely to be the treatment of choice, but until approval is granted it should be reserved for special forms of scabies.
  • Lichen sclerosus is a chronic inflammatory disease that occurs as atrophic white patches on the glans penis and foreskin.
  • The penile form is a common cause of phimosis in uncircumcised men; involvement of the urethral meatus may lead to progressive meatal stenosis.
  • Plasma cell balanitis is a benign, idiopathic condition presenting as a solitary, smooth, shiny, red-orange plaque of the glans and prepuce of a middle-aged to older man.
  • Squamous cell carcinoma (SCC) in situ, e.g. erythroplasia of Queyrat and Bowen's disease, cannot be excluded clinically; their apparent clinical benignity may lead to lengthy periods of misdiagnosis and biopsy is required to confirm the diagnosis.
  • SCC is the most common malignancy of the penis and the role of oncogenic HPV-types has been also established in SCC of the penis.
  • Prevention of SCC of the penis presupposes an identification of risk factors, early detection of all pre-cancerous lesions and treatment of phimosis.
  • [MeSH-major] Penile Diseases. Skin Diseases
  • [MeSH-minor] Balanitis / diagnosis. Balanitis / therapy. Humans. Male. Mite Infestations / diagnosis. Mite Infestations / therapy. Penile Neoplasms / diagnosis. Penile Neoplasms / therapy. Skin Diseases, Parasitic / diagnosis. Skin Diseases, Parasitic / therapy. Skin Diseases, Viral / diagnosis. Skin Diseases, Viral / therapy

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  • (PMID = 12175386.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 39
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8. Skripuletz T, Pul R, Herrmann J, Bueltmann E, Wurster U, Stangel M, Trebst C: Meningeal carcinomatosis from penile squamous cell carcinoma. J Neurooncol; 2010 Jul;98(3):417-9
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  • [Title] Meningeal carcinomatosis from penile squamous cell carcinoma.
  • We report herein a clinical case of a patient with meningeal carcinomatosis from penile squamous cell carcinoma.
  • Examinations revealed brain metastases and infiltration of the leptomeninges and subarachnoid space by carcinoma cells.
  • Only 11 months earlier the patient had been diagnosed with penile squamous cell carcinoma of poor differentiation and had underwent subtotal penectomy and adjuvant chemotherapy and radiation.
  • Infiltration of the central nervous system with penile cancer is extremely rare, and only five cases with brain metastases have been described to date.
  • This is the first report of a patient with penile cancer spread to the leptomeninges.
  • [MeSH-major] Carcinoma / secondary. Carcinoma, Squamous Cell / pathology. Meningeal Carcinomatosis / secondary. Penile Neoplasms / pathology
  • [MeSH-minor] Aged. Humans. Male. Tomography Scanners, X-Ray Computed

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  • (PMID = 20013145.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Tan JM, Jin XL, Gao Y, Xu DF, Zhou WM, Zhang TL, Xu JJ, Fu XH: [Treatment of 58 cases of penile squamous cell carcinoma]. Zhonghua Nan Ke Xue; 2010 Sep;16(9):822-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of 58 cases of penile squamous cell carcinoma].
  • OBJECTIVE: To search for rational and effective treatments for penile squamous cell carcinoma (PSCC).
  • METHODS: We retrospectively analyzed the clinical data of 58 cases of pathologically confirmed PSCC, focusing on the treatment methods.
  • Fifty-three of the patients were treated by surgery, of whom 43 underwent limited resection of the tumor or partial amputation of the penis, and the other 10 received total penis amputation plus perineal urethrostomy and clearance of lymphoglandulae iliacae and inguinal lymph nodes, with the lymphoglandulae iliacae positive in 1 case and the inguinal lymph nodes positive in all.
  • Thirty-seven cases received neoadjuvant hormonal therapy (thermotherapy plus chemotherapy) and combined postoperative chemotherapy, 12 postoperative chemotherapy only, and 4 merely surgery.
  • Five of the total number underwent chemotherapy and/or radiotherapy without surgery.
  • The 2-5 years follow-up of 48 patients found recurrence in 4 cases of partial penis amputation within 2 years, 4 deaths within 2 years, 7 deaths from 2 to 5 years.
  • CONCLUSION: Surgery + neoadjuvant hormonal therapy + postoperative chemotherapy and/or radiotherapy is an effective method for PSCC, but whether it can reduce the recurrence of PSCC and improve the survival of the patients remains to be further studied.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Penile Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 21171268.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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10. Bermejo C, Busby JE, Spiess PE, Heller L, Pagliaro LC, Pettaway CA: Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma. J Urol; 2007 Apr;177(4):1335-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma.
  • PURPOSE: Combination chemotherapy for advanced penile cancer can produce partial response rates of up to 64%.
  • Complete responses are rare, suggesting a need for adjunct therapies to facilitate cure.
  • We evaluated patients with metastases who underwent surgical consolidation after responding to chemotherapy.
  • MATERIALS AND METHODS: We reviewed the records of 59 patients with advanced penile carcinoma treated from 1985 to 2000 and identified 10 treated with surgical consolidation after demonstrating a stable, partial or complete response to chemotherapy.
  • RESULTS: After chemotherapy 4 patients had a complete response, 1 had a partial response and 5 had stable disease.
  • All 3 patients received ifosfamide, paclitaxel and cisplatin chemotherapy.
  • For all patients the 5-year actuarial survival rate was 40% with a median survival of 26 months.
  • CONCLUSIONS: Select patients with metastatic penile cancer that shows disease stabilization or a response to chemotherapy should be considered for surgical consolidation to extend survival.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / surgery. Penile Neoplasms / drug therapy. Penile Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Humans. Male. Middle Aged. Neoadjuvant Therapy

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  • (PMID = 17382727.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Marconnet L, Bouchot O, Culine S, Avances C, Rigaud J, membres du CCAFU-OGE: [Treatment of lymph nodes in epidermoid carcinoma of the penis: review of literature by the Committee of Cancerology of the French Association of Urology-External Genital Organs Group (CCAFU-OGE)]. Prog Urol; 2010 May;20(5):332-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment of lymph nodes in epidermoid carcinoma of the penis: review of literature by the Committee of Cancerology of the French Association of Urology-External Genital Organs Group (CCAFU-OGE)].
  • [Transliterated title] Prise en charge ganglionnaire dans le carcinome épidermoïde du pénis: revue de la littérature par le comité de cancérologie de l'Association française d'urologie-groupe organes génitaux externes (CCAFU-OGE).
  • INTRODUCTION: Invasive lymph nodes are an independent factor of prognosis and essential for the survival of patients with cancer of the penis.
  • The aim of this article is to analyse published research results on the diagnosis and treatment of lymph nodes in cancer of the penis.
  • MATERIAL AND METHOD: Bibliographic research on Medline was carried out using the terms penile carcinoma, lymph node dissection, lymphadenectomy, survival, chemotherapy and radiotherapy.
  • A diagnosis of suspected adenopathy based on clinical examination associated with FNA biopsy is essential.
  • Not only is surgery on inguinal lymph nodes the only reliable way of confirming an invasive metastatic lymph node, it also plays a therapeutic and prognostic role for patients who have a tumour of the penis which risks spreading to lymph nodes (intermediate or high risk according to EAU).
  • The type of dissection is in function with the clinical examination: a radical inguinal dissection is recommended in the case of palpated adenopathy and a modified inguinal dissection is recommended if there is no palpated adenopathy, this should be radicalised in the case of metastatic adenopathy on histological examination.
  • Neo-adjuvant or adjuvant chemotherapy would appear to play a interesting role when combined with surgery for certain patients without there being currently being precise consensus because of the lack of documented cases.
  • CONCLUSION: Lymph node dissection alone has a therapeutic role in patients who have reached metastasis of lymph nodes (stage pN1).
  • Consequently, it would seem important to develop multimodal approaches in the treatment of these patients in order to increase the rate of response to treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lymph Node Excision. Penile Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. France. Humans. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Societies, Medical. Urology

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20471577.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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12. Bevan-Thomas R, Slaton JW, Pettaway CA: Contemporary morbidity from lymphadenectomy for penile squamous cell carcinoma: the M.D. Anderson Cancer Center Experience. J Urol; 2002 Apr;167(4):1638-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contemporary morbidity from lymphadenectomy for penile squamous cell carcinoma: the M.D. Anderson Cancer Center Experience.
  • PURPOSE: Inguinal lymphadenectomy can be curative in patients with small volume inguinal metastases and those with more significant adenopathy responding to combination chemotherapy.
  • We reviewed our recent experience with lymphadenectomy in patients with invasive penile cancer who were judged to require inguinal staging and therapeutic procedures to assess the incidence and magnitude of complications caused by this procedure, especially in those with no palpable adenopathy (prophylactic group).
  • The indications for dissection were prophylactic in 66 (62%) patients in whom a superficial dissection alone was completed on the ipsilateral side, therapeutic in 28 (26%) in whom superficial, deep and ipsilateral pelvic dissections were performed, and palliative in 12 (11%) undergoing extensive resection of inguinal and abdominal wall tissue after chemotherapy.
  • Minor postoperative complications included those requiring local wound débridement in the clinic, mild to moderate leg edema, seroma formation not requiring aspiration and minimal skin edge necrosis requiring no therapy.
  • Prophylactic and therapeutic dissections were associated with a lower incidence of complications compared with palliative dissections (p = 0.017 to 0.049).
  • Similarly the morbidity of therapeutic lymphadenectomy appeared acceptable, considering the potential therapeutic benefit.
  • Optimal candidates are those having a significant response to systemic chemotherapy whose groins are grossly uninfected.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lymph Node Excision / adverse effects. Penile Neoplasms / surgery

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  • (PMID = 11912379.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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13. Preis E, Jakse G: [The significance of inguinal lymphadenectomy in carcinoma of the penis]. Urologe A; 2006 Sep;45 Suppl 4:176-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The significance of inguinal lymphadenectomy in carcinoma of the penis].
  • The occurrence of inguinal lymph node metastases from squamous cell carcinoma of the penis depends on local tumor extension, tumor grade, and vascular invasion.
  • Whilst imaging techniques and fine needle biopsy can detect metastases to the inguinal nodes, resection of the superficial inguinal nodes remains the procedure of choice for diagnosis.
  • Chemotherapy and radiotherapy and the two combined have not been tested for efficacy, but are used individually before and after surgery, depending on the local tumor extent.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lymph Node Excision / methods. Penile Neoplasms / surgery
  • [MeSH-minor] Germany. Humans. Inguinal Canal. Lymphatic Metastasis / pathology. Male. Neoplasm Invasiveness. Neoplasm Staging. Penis / pathology. Postoperative Complications / etiology. Practice Guidelines as Topic. Prognosis. Sentinel Lymph Node Biopsy

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  • [Cites] Semin Surg Oncol. 1990;6(4):241-2 [2389105.001]
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  • (PMID = 16933120.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 46
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14. Iborra F, Neuzillet Y, Méjean A, Lebret T: [Metastases from squamous cell carcinoma of the penis]. Prog Urol; 2008 Nov;18 Suppl 7:S392-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastases from squamous cell carcinoma of the penis].
  • [Transliterated title] Métastases des cancers du pénis.
  • Penile cancer is a rare carcinoma and visceral metastases are uncommon.
  • Metastasis diagnosis is carried out with TDM and MRI but markers can sometimes be helpful (ie SSCAg).
  • There is no referent chemotherapy, a trial has been started (CAVER).
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Penile Neoplasms / pathology

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  • (PMID = 19070821.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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15. Lutterbach J, Pagenstecher A, Weyerbrock A, Schultze-Seemann W, Waller CF: Early-stage penile carcinoma metastasizing to brain: case report and literature review. Urology; 2005 Aug;66(2):432
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early-stage penile carcinoma metastasizing to brain: case report and literature review.
  • Early-stage penile squamous cell carcinoma with subsequent distant metastases is rare.
  • We report a case of a 35-year-old man with Stage pT1pN0 penile squamous cell carcinoma who underwent circumcision and bilateral inguinal lymphadenectomy.
  • Further in the disease course, the patient developed metastases in the kidney, adrenal gland, retroperitoneal lymph nodes, lung, and brain.
  • He underwent multiple resections, whole brain radiotherapy, and several chemotherapy regimens.
  • Forty months after the first diagnosis, the patient died of thromboembolic complications.
  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma, Squamous Cell / secondary. Penile Neoplasms / pathology

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  • (PMID = 16098372.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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16. de los Rios Osorio J, Castro Alvarez EA: [Analysis of 5000 vasectomies at a family planning clinic in Medellin-Colombia]. Arch Esp Urol; 2003 Jan-Feb;56(1):53-60
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  • [Transliterated title] Análisis de 5000 vasectomías de un centro de planificación familiar en Medellín-Colombia.
  • OBJECTIVES: To study the evolution of 49 patients with squamous cell carcinoma of the penis.
  • METHODS: 49 patients who underwent surgery for squamous cell carcinoma of the penis (30 partial penile amputations, 11 total amputations and 7 circumcisions).
  • 27 inguinal lymphadenectomies, superficial, profound and ilio-obturator (2 cases), were performed due to persistent lymph nodes after penile amputation despite of antibiotic treatment for 4 weeks, or to high grade primary tumour.
  • 13 patients were found to have lymph node metastases after treatment, receiving posterior adjuvant treatment with radiotherapy, chemotherapy or a combination of them.
  • Patients were followed in relation to stage, cell differentiation degree, and presence or absence of positive lymph nodes and distant metastases.
  • 6 patients died from tumour dissemination, 2 of them were T2G2, one T2G1, and three T1G2; two additional patients died from causes different from the tumour, all of them being N+ at the time of diagnosis.
  • CONCLUSIONS: Penile squamous cell carcinoma is an aggressive tumour the evolution of which mainly depends on the local-regional stage at the time of diagnosis and cell differentiation; these factors will condition lymphadenectomy versus observation.

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  • (PMID = 12701481.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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17. Novák J, Bárta J, Klézl P: [Carcinoma of the penis]. Cas Lek Cesk; 2007;146(10):767-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Carcinoma of the penis].
  • [Transliterated title] Karcinom penisu.
  • BACKGROUND: Experience with diagnosis and results of the treatment cancer of the penis are comparatively sparse.
  • We present our experience and treatment results of patients with this diagnosis.
  • In 93% of cases the disease originated from an untreated phimosis Squamous cell cancer was found in 91% of the biopsies.
  • Interstitial brachytherapy Ir 192 was first used as organ preserving treatment modality for patients with SCC in Czech Republic.
  • For the patients with positive lymph nodes, chemotherapy as neoadjuvant or adjuvant treatment approach was indicated.
  • Treatment complications intra- or postoperative were minimal.
  • CONCLUSIONS: We recommended concentrating patients with this relatively rare disease to the special department with complete diagnostic and treatment care.
  • [MeSH-major] Penile Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / therapy. Humans. Male. Middle Aged

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  • (PMID = 18020009.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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18. Venkov G: [Verrucous carcinoma of the penis]. Khirurgiia (Sofiia); 2003;59(6):22-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Verrucous carcinoma of the penis].
  • OBJECTIVE: The objective of the present retrospective research is to examine cases of verrucous carcinoma of the penis, an uncommon variant of squamous cell carcinoma, as well as to examine the localisation, evolvement and the ways of treatment.
  • METHODS: Patients, treated for carcinoma of the penis at the Clinic of Urology, have been examined for a 13-year interval.
  • From 80 cases of cancer localized in the penis, in only 3 of these verrucous carcinoma has been histologically proved, accounting for 2.4 per cent of the penile cancers.
  • A rare case of a hybrid tumor between verrucous carcinoma and invasive squamous cell carcinoma, which is compared to similar finding as described by other authors.
  • The tumor has been mainly localized on the surface of the Glans penis.
  • CONCLUSION: Wide surgical excision, usually requiring partial or total penectomy, is the treatment of choice.
  • Radiotherapy and chemotherapy have proved to be unsuccessful.
  • [MeSH-major] Carcinoma, Verrucous / surgery. Penile Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome. Urologic Surgical Procedures, Male

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  • (PMID = 15641556.001).
  • [ISSN] 0450-2167
  • [Journal-full-title] Khirurgii︠a︡
  • [ISO-abbreviation] Khirurgiia (Sofiia)
  • [Language] bul
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Bulgaria
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19. Otto T, Suhr J, Krege S, Rübben H: [Therapy of advanced penis carcinoma]. Urologe A; 2003 Nov;42(11):1466-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Therapy of advanced penis carcinoma].
  • [Transliterated title] Die Therapie des fortgeschrittenen Peniskarzinoms.
  • Skin infiltration and locoregional lymph node extension in metastatic penile cancer leads to destruction in the inguinal and perineal region.
  • The obligatorily superinfected defects require tension-free and extended coverage with immediate myocutaneous flaps after surgical resection.
  • Data concerning a prospective study for neoadjuvant chemotherapy with CMB followed by surgical tumor resection with immediate myocutaneous flap reconstruction are presented.
  • In 15 patients (median age: 69.7 years) suffering from squamous cell carcinoma of the penis (Tx, N3, M1 cutis), a surgical excision of the tumor was performed after neoadjuvant chemotherapy (median:2.4 cycles) and antibiotic pretreatment.
  • All patients received coverage of the femoral vessels with a musculus sartorius transfer on both sides.
  • An extended (up to 45x30 cm) tension-free coverage of groin defects was performed in two patients with a unilateral M. tensor fasciae latae flap (TFL) and in eight patients with a bilateral TFL.
  • One patient received a M. gluteus maximus flap (GMFL) on both sides, three patients were treated with a combination of M. rectus abdominis flap (RFL) and TFL, and one patient received a combination of two TFL, one GMFL as well as one RFL.
  • Of 31 myocutaneous pedicle flaps, 2 developed distant necrosis of the flap, in which one GMFL and one TFL were affected.
  • The covering of groin defects by the use of myocutaneous flaps, such as the M. tensor fasciae latae, M. rectus abdominis, and M. gluteus maximus flap, is a method of first choice in the primary treatment of even bacterially contaminated wounds or after radiation therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Neoadjuvant Therapy. Penile Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antibiotic Prophylaxis. Bleomycin / administration & dosage. Bleomycin / adverse effects. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Graft Survival / drug effects. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Methotrexate / administration & dosage. Methotrexate / adverse effects. Microsurgery. Neoplasm Invasiveness. Neoplasm Staging. Skin / pathology. Superinfection / prevention & control. Surgical Flaps / blood supply. Surgical Wound Infection / prevention & control. Suture Techniques. Treatment Outcome. Wound Healing / drug effects

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  • (PMID = 14624345.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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20. Shi YL, Yin HL, Zhou XJ, Zhou HB, Lu ZF: [Primary peripheral T-cell lymphoma of the penis: a case report and review of the literature]. Zhonghua Nan Ke Xue; 2008 Nov;14(11):1003-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary peripheral T-cell lymphoma of the penis: a case report and review of the literature].
  • OBJECTIVE: To report a case of primary peripheral T-cell lymphoma of the penis.
  • METHODS: We analyzed the clinicopathological characteristics of the case of primary peripheral T-cell lymphoma using histological, cytochemical and immunohistochemical methods and by review of the literature.
  • RESULTS: The patient was a 65 years old man and presented with a diffuse enlargement of the penis as the initial sign, followed by erosive ulcer in the caput penis and inguinal lymphadenectasis.
  • Clinically it responded to the chemotherapy designed for peripheral T-cell lymphoma.
  • CONCLUSION: Primary peripheral T-cell lymphoma of the penis is an extremely rare malignant tumor, the diagnosis of which relies on histopathological examination, immunohistochemical staining and differentiation between squamous cell carcinoma and other types of lymphoma.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral. Penile Neoplasms

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  • (PMID = 19102501.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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21. Das S, Tunuguntla HS: Balanitis xerotica obliterans--a review. World J Urol; 2000 Dec;18(6):382-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • With a high degree of suspicion and histologic examination, the condition will prove to be much more frequent than one generally believes.
  • Many cases of BXO occurring after circumcision may be cases of secondary phimosis due to BXO not being recognized at the time of surgery.
  • Biopsy of the lesions is not essential in all cases and is indicated to differentiate from penile cancer and in atypical cases.
  • Early diagnosis and treatment of BXO are very important in preventing the urological complications of the diseases such as urethral stricture.
  • Treatment of BXO depends on the anatomic location of the lesions and their extent and severity, together with the rapidity of progression of the disease process.
  • The treatment may vary from topical corticosteroids, laser vaporization in early cases to meatoplasty and urethroplasty in extensive cases.
  • Topical pharmacotherapy is useful in the early stages to reduce the initial symptoms and slow down the progression, but is not effective in all cases and is not the curative treatment of disease.
  • Meatal stenosis, phimosis, scar adhesions, fissures, erosions of glans and prepuce and involvement of the urethra are indications for surgical treatment.
  • Surgery seems to be the only treatment that can relieve the symptoms of advanced disease.
  • Excision of the scleroatrophic tract and grafting of the glans base, coronal sulcus, and the end of the shaft give a complete relief of pain during erection and intercourse in circumcised patients with balanopreputial adhesions and restore the elasticity of the skin of penile shaft.
  • The complete excision of the stricture and flap urethroplasty seems to be better than a 2-stage procedure.
  • However, at the present time, it is not possible to say that surgery can completely resolve this chronic and progressive disease.
  • Despite many reports in the literature of cases of BXO associated with squamous cell carcinoma, the etiologic relationship between the two conditions is uncertain.

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  • (PMID = 11204255.001).
  • [ISSN] 0724-4983
  • [Journal-full-title] World journal of urology
  • [ISO-abbreviation] World J Urol
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
  • [Number-of-references] 27
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22. Di Capua Sacoto C, Lujan Marco S, Morales Solchaga G, Budía Alba A, Pontones Moreno JL, Jiménez Cruz JF: [Cancer of the penis. Our experience in 15 years]. Actas Urol Esp; 2009 Feb;33(2):143-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cancer of the penis. Our experience in 15 years].
  • [Transliterated title] Cáncer de pene. Nuestra experiencia en 15 años.
  • OBJECTIVE: To review and analysis the diagnosis, treatment, evolution, and risk factors of the penis cancer.
  • We included 47 patients with penis cancer diagnose of treated in our service.
  • We analyzed risk factors, symptoms, diagnosis and treatment.
  • The average time of follow-up was 50 months {range 12 to 120 months).
  • At the diagnosis 16 patients (34%) had lymphatic nodes, being the most frequent location was unilateral inguinal nodes (62%).
  • Of the 27 cases (57%) who underwent blood calcium check at the time of diagnosis, we found hypercalcaemia in 8 patients (30%).
  • The surgical treatment was the gold standard treatment.
  • 4 patients received radiotherapy as initial treatment.
  • The pathology finding at 100% of the cases was squamous cell carcinoma (80% well differentiated).
  • The most significant adverse prognostic factors were the presence of lymph nodes, clinical stage at the diagnosis and the degree of cell differentiation (p = 0001).
  • There were 11 (24%) cases that presented recurrence and were treated: 3 patients with radiotherapy, surgery was used in 7 patients and 1 patient with chemotherapy.
  • CONCLUSIONS: The carcinoma of the penis remains a rare malignancy in our centre.
  • The most significant adverse prognostic factors were the presence of lymph nodes, clinical stage at the diagnosis and the degree of cell differentiation.
  • The most effective treatment for cancer of the penis is surgery reserving chemotherapy and radiation therapy for the recurrence.
  • [MeSH-major] Penile Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Retrospective Studies. Time Factors

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  • (PMID = 19418837.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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23. Axcrona K, Brennhovd B, Alfsen GC, Giercksky KE, Warloe T: Photodynamic therapy with methyl aminolevulinate for atypial carcinoma in situ of the penis. Scand J Urol Nephrol; 2007;41(6):507-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photodynamic therapy with methyl aminolevulinate for atypial carcinoma in situ of the penis.
  • OBJECTIVE: Photodynamic therapy (PDT) has been investigated as an alternative treatment for cutaneous squamous cell carcinoma in situ (CIS), also known as Bowen's disease.
  • Atypia of the squamous epithelium is graded, with the most severe atypia being equivalent to CIS.
  • CIS on the penis is regarded as a premalignant condition and is seen either in isolation or in conjunction with carcinoma of the penis.
  • The group consisted of five patients with primary lesions and five with atypia after an organ-preserving operation for carcinoma of the penis.
  • RESULTS: Eight patients were treated once, one twice and one six times.
  • When complete remission was not achieved, a biopsy was taken for diagnosis.
  • The first week after treatment could be painful but the cosmetic results were excellent.
  • CONCLUSIONS: In our experience, PDT for CIS seems to be a promising treatment modality with regard to cancer control, organ preservation, cosmetics and functional results.
  • As with laser therapy of these lesions, careful follow-up is mandatory.
  • [MeSH-major] Aminolevulinic Acid / analogs & derivatives. Bowen's Disease / drug therapy. Penile Neoplasms / drug therapy. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 17853049.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / methyl 5-aminolevulinate; 88755TAZ87 / Aminolevulinic Acid
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24. Zhu Y, Li H, Yao XD, Zhang SL, Zhang HL, Shi GH, Yang LF, Yang ZY, Wang CF, Ye DW: Feasibility and activity of sorafenib and sunitinib in advanced penile cancer: a preliminary report. Urol Int; 2010;85(3):334-40
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  • [Title] Feasibility and activity of sorafenib and sunitinib in advanced penile cancer: a preliminary report.
  • INTRODUCTION: We describe our experience with sorafenib and sunitinib in the treatment of chemotherapy-refractory advanced penile squamous cell carcinoma (SCC).
  • PATIENTS AND METHODS: Between May 2008 and June 2009, 6 advanced penile cancer patients were treated with sorafenib or sunitinib in our center.
  • All of them had previously received at least two chemotherapy regimens.
  • Immunohistochemical staining of CD34 and Ki-67 was performed in 3 paired tumor tissues before and after treatment.
  • After molecular-targeted therapies, reduction in microvessel density and Ki-67 labeling index was observed in paired specimens.
  • Serum SCC antigen levels were decreased in 5 patients after 1 week of medication.
  • The patient who achieved partial response had an SCC antigen reduction of nearly 95% after treatment with sunitinib.
  • Serious adverse events were fatal infection and rupture of the femoral vessel, which were unlikely related to the medication.
  • CONCLUSIONS: The feasibility and activity of sorafenib and sunitinib in our series suggest that this approach may be a promising alternative in chemotherapy-refractory advanced penile SCC.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Benzenesulfonates / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Indoles / therapeutic use. Penile Neoplasms / drug therapy. Pyridines / therapeutic use. Pyrroles / therapeutic use
  • [MeSH-minor] Adult. Antigens, CD34 / biosynthesis. Humans. Immunohistochemistry / methods. Ki-67 Antigen / biosynthesis. Male. Middle Aged. Neoplasm Metastasis. Niacinamide / analogs & derivatives. Phenylurea Compounds. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20980789.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Indoles; 0 / Ki-67 Antigen; 0 / Phenylurea Compounds; 0 / Pyridines; 0 / Pyrroles; 0 / sunitinib; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
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25. Zhu Y, Ye DW, Yao XD, Zhang SL, Dai B, Zhang HL, Shen YJ: The value of squamous cell carcinoma antigen in the prognostic evaluation, treatment monitoring and followup of patients with penile cancer. J Urol; 2008 Nov;180(5):2019-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of squamous cell carcinoma antigen in the prognostic evaluation, treatment monitoring and followup of patients with penile cancer.
  • PURPOSE: We examined whether squamous cell carcinoma antigen has significant value for prognostic evaluation, treatment monitoring and followup in patients with penile cancer.
  • MATERIALS AND METHODS: Serum squamous cell carcinoma antigen was prospectively measured in 63 patients with penile squamous cell carcinoma from 2005 to 2007.
  • The normal range of squamous cell carcinoma antigen was set as less than 1.50 mug/l.
  • RESULTS: Of all patients 23.8% had a value of squamous cell carcinoma antigen that was greater than the upper limit of normal.
  • However, squamous cell carcinoma antigen could not accurately predict occult inguinal lymph node metastasis in clinically node negative cases.
  • Preoperatively squamous cell carcinoma antigen was an independent prognostic factor for disease-free survival in patients with node positive penile cancer (OR 0.13, p = 0.006).
  • Combining pretreatment squamous cell carcinoma antigen and the percent of decrease after surgery was informative for predicting disease recurrence.
  • The prognostic value of squamous cell carcinoma antigen was also observed in a small number of patients treated with chemotherapy.
  • During followup continuously increasing squamous cell carcinoma antigen indicated tumor progression without a significant lead time effect.
  • CONCLUSIONS: Squamous cell carcinoma antigen is not a sensitive marker of tumor burden.
  • However, it has prognostic significance for disease-free survival in patients with penile cancer treated with surgery.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / therapy. Penile Neoplasms / mortality. Penile Neoplasms / therapy. Serpins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Combined Modality Therapy. Evaluation Studies as Topic. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Probability. Prognosis. Proportional Hazards Models. Prospective Studies. Radiotherapy, Adjuvant. Risk Assessment. Sensitivity and Specificity. Statistics, Nonparametric. Survival Rate. Treatment Outcome. Urologic Surgical Procedures, Male / methods

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  • (PMID = 18801542.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Serpins; 0 / squamous cell carcinoma-related antigen
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26. Zheng FF, Liang YY, Guo YS, Dai YP, Zheng KL: [Diagnosis and therapy for penile cancer: a report of 46 cases with literature review]. Ai Zheng; 2008 Sep;27(9):962-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and therapy for penile cancer: a report of 46 cases with literature review].
  • BACKGROUND & OBJECTIVE: Penile cancer is an uncommon malignancy, which is mainly treated by surgery, radiation and chemotherapy.
  • This study was to investigate reasonable curative methods for penile cancer.
  • METHODS: Medical records of 46 patients with penile cancer in the Department of Urology, The First Affiliated Hospital of Sun Yat-sen University between Jan.
  • Forty-four patients had squamous cell carcinoma, one had Paget disease, and one had verrucous carcinoma.
  • CONCLUSIONS: Partial penectomy is an appropriate and effective management for penile cancer.
  • Lymph node metastasis is an important prognostic factor for penile cancer.
  • Patients with ilioinguinal lymph node metastasis should receive lymphadenectomy as early as possible to improve the therapeutic effect.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Penile Neoplasms / surgery. Penis / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Verrucous / pathology. Carcinoma, Verrucous / surgery. Carcinoma, Verrucous / therapy. Chemotherapy, Adjuvant. Follow-Up Studies. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Paget's Disease, Mammary / pathology. Paget's Disease, Mammary / surgery. Paget's Disease, Mammary / therapy. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 18799036.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 12
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27. Syed S, Eng TY, Thomas CR, Thompson IM, Weiss GR: Current issues in the management of advanced squamous cell carcinoma of the penis. Urol Oncol; 2003 Nov-Dec;21(6):431-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current issues in the management of advanced squamous cell carcinoma of the penis.
  • Effective treatment of penile carcinoma incorporates three modalities: surgery, radiation and chemotherapy.
  • In certain patients radiation therapy may be utilized to eradicate the tumor and allow organ preservation.
  • For patients with locally advanced disease, multi-modality approaches incorporating adjuvant or neoadjuvant chemotherapy and radiation therapy need to be studied.
  • Finally, in the setting of metastatic disease, less toxic and more effective combination chemotherapy are sought.
  • Novel targeted therapies that have been successful in squamous cell carcinoma at other sites must also be studied in this disease.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Penile Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant. Combined Modality Therapy. Humans. Male. Prognosis

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  • (PMID = 14693269.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 86
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28. Pizzocaro G, Algaba F, Horenblas S, Solsona E, Tana S, Van Der Poel H, Watkin NA, European Association of Urology (EAU) Guidelines Group on Penile Cancer: EAU penile cancer guidelines 2009. Eur Urol; 2010 Jun;57(6):1002-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] EAU penile cancer guidelines 2009.
  • CONTEXT: Squamous cell carcinoma (SCC) of the penis is a relatively rare but ominous disease.
  • OBJECTIVE: To present a condensed version of the updated 2009 European Association of Urology (EAU) guidelines on penile SCC.
  • EVIDENCE SYNTHESIS: More insight was gained into the etiology of SCC of the penis, together with improved staging and treatment: Human papillomavirus 16 plays an etiologic role in approximately 40-50% of cases.
  • Improved diagnostics allowed earlier diagnosis, leading to more conservative treatments.
  • Adjuvant and neoadjuvant chemotherapy showed promising results in patients with advanced or recurrent disease.
  • Centralization of the disease contributed to standardization and rapid diffusion of new treatments with improved results and increased organ preservation.
  • CONCLUSIONS: Improvements in the management of SCC of the penis are reflected in changes in the guidelines, but the rarity of the disease precluded randomized studies, leading to low level of evidence and grade of recommendation.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Penile Neoplasms / diagnosis. Penile Neoplasms / therapy. Quality of Life / psychology

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  • [Copyright] Copyright © 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20163910.001).
  • [ISSN] 1873-7560
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] Switzerland
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29. Phé V, Rouprêt M, Mottet N: [What's new in 2008 in the field of basic and clinical research in testicular and penile cancer?]. Prog Urol; 2009 May;19 Suppl 2:S51-5
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  • [Title] [What's new in 2008 in the field of basic and clinical research in testicular and penile cancer?].
  • [Transliterated title] Quelles nouveautes en 2008 dans le cancer du testicule et du pénis en recherche clinique et en recherche fondamentale ?
  • In stage I testis seminomas, data comparing 1 course of chemotherapy by carboplatin (AUC: 7) to retroperitoneal radiotherapy in adjuvant treatment were updated.
  • Localizations of recurrences were different, depending on adjuvant treatment.
  • In stage I non seminomatous testis cancer, active surveillance could be possible if there were not any vascular embols.
  • Chemotherapy by 1 course of BEP was superior to retroperitoneal lymph node dissection in stage I.
  • In Leydig cell tumors, conservative surgery was possible.
  • In penile cancer management, dynamic sentinel node biopsy could be interesting.
  • Carbon-dioxide laser microsurgery only for initially invasive squamous cell carcinoma of the penis could be proposed.
  • [MeSH-major] Penile Neoplasms / therapy. Testicular Neoplasms / therapy

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  • (PMID = 19447329.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 17
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30. Borchers H, Jakse G: [Lymphadenectomy for penile cancer. Diagnostic and prognostic significance as well as therapeutic benefit]. Urologe A; 2005 Jun;44(6):657-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lymphadenectomy for penile cancer. Diagnostic and prognostic significance as well as therapeutic benefit].
  • Lymphadenectomy is an essential part of diagnosis and treatment of the squamous cell carcinoma of the penis.
  • Lymphadenectomy is performed depending on various characteristics of penile cancer such as depth of invasion, tumor grade, invasion into the corpora cavernosa, invasion into vascular and lymphatic vessels.
  • The limits of lymphadenectomy are extended to the radical type of dissection when the frozen section indicates cancer.
  • Neoadjuvant chemotherapy is reasonable for patients with bulky nodes fixed to the skin or fascia because this improves respectability, freedom from local recurrence and increases survival.
  • Adjuvant chemo- and/or radio-therapy are reserved for extended disease or palliative situations.
  • [MeSH-major] Lymph Node Excision / methods. Lymph Nodes / pathology. Lymph Nodes / surgery. Penile Neoplasms / pathology. Penile Neoplasms / surgery. Prostatectomy / methods. Risk Assessment / methods

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  • (PMID = 15891865.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 21
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31. Bissada NK, Yakout HH, Fahmy WE, Gayed MS, Touijer AK, Greene GF, Hanash KA: Multi-institutional long-term experience with conservative surgery for invasive penile carcinoma. J Urol; 2003 Feb;169(2):500-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multi-institutional long-term experience with conservative surgery for invasive penile carcinoma.
  • PURPOSE: Invasive squamous cell carcinoma of the penis occurs on the glans, prepuce, glans and prepuce, coronal sulcus and shaft.
  • Penile squamous cell carcinoma subsequently invades local structures, corpora cavernosa and the urethra, and metastasizes to the inguinal lymph nodes.
  • Invasive squamous cell carcinoma of the penis usually requires total or partial penectomy.
  • We studied the effect of primary tumor resections tailored to the anatomical extent of the cancer with preservation of uninvolved structures in select patients with invasive penile squamous cell carcinoma.
  • MATERIALS AND METHODS: A total of 30 patients between 39 and 82 years old were treated with unconventional conservative surgical excision of the primary penile lesion.
  • Chemotherapy was given to 7 patients with extensive inguinal lymphadenopathy and to 2 of 5 with pathologically positive lymph nodes.
  • Tumor resection with no sacrifice of function was performed in 2 patients in whom 3 small recurrences developed.
  • Of the 7 patients with advanced lymphadenopathy 5 and of 5 patients with pathologically positive lymph nodes at presentation 1 died of the cancer but had no local recurrence in the penis.
  • CONCLUSIONS: In a minority of patients with anatomically suitable penile cancer conservative surgical techniques are safe and provide equal tumor control compared to conventional resections.
  • The anatomical situation and tumor characteristics should dictate the choice of treatment for the primary penile lesion.
  • Inguinal lymph nodes should be managed by appropriately established guidelines but should not influence the extent of primary penile lesion resection.
  • [MeSH-major] Penile Neoplasms / surgery. Urologic Surgical Procedures, Male / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Invasiveness. Time Factors

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  • (PMID = 12544296.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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32. Slampa P, Kost'áková G, Hynková L, Růzicková J, Horová H, Jezková B: [Conservative treatment for the penis carcinoma]. Cas Lek Cesk; 2004;143(9):589-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Conservative treatment for the penis carcinoma].
  • [Transliterated title] Konzervativní lécba karcinomu penisu.
  • No explicit recommendation has been determined in a treatment for the verified squamous cell penis carcinoma till now.
  • The application of ionizing radiation is included in traditional treatment methods for this disease, in addition to surgical operations and chemotherapy cure.
  • Radiotherapy has its place in the neoadjuvans treatment with the goal to reduce the disease extent.
  • This review is describing principles of the radiotherapy treatment for this disease.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Penile Neoplasms / radiotherapy
  • [MeSH-minor] Combined Modality Therapy. Humans. Male

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  • (PMID = 15532896.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 19
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33. Skeel RT, Huang J, Manola J, Wilding G, Dreicer R, Walker P, Muggia F, Crawford ED, Dutcher JP, Loehrer PJ: A phase II study of 13-cis retinoic acid plus interferon alpha-2a in advanced stage penile carcinoma: an Eastern Cooperative Oncology Group study (E3893). Cancer Invest; 2003;21(1):41-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A phase II study of 13-cis retinoic acid plus interferon alpha-2a in advanced stage penile carcinoma: an Eastern Cooperative Oncology Group study (E3893).
  • PURPOSE: Combined biological therapy with 13-cis-retinoic acid (13-cRA) and interferon alpha-2a (IFN alpha-2a) was reported to be highly effective in squamous cell carcinoma of the cervix and skin.
  • Squamous cell carcinoma of the penis is rare in the United States, accounting for less than 1/2% of all male malignancies.
  • Because of the association of infection with human papillomavirus with both carcinomas of the cervix and penis and their shared squamous cell histology, we carried out a phase II study of 13-cRA and IFN alpha-2a in carcinoma of the penis.
  • MATERIALS AND METHODS: Eighteen ambulatory patients with surgically unresectable, recurrent, and/or metastatic squamous cell carcinoma of the penis were treated with IFN alpha-2a, 3MU/day administered subcutaneously and 13-cRA, 1 mg/kg orally daily for at least eight weeks, unless intolerable toxicity occurred.
  • RESULTS: One patient was ineligible; one patient withdrew prior to treatment.
  • Fourteen patients had progressive disease as their only treatment effect.
  • No unexpected treatment-related toxicities were found on study.
  • CONCLUSION: In contrast to its benefit in squamous cell carcinomas of the cervix and skin, the combination of 13-cRA and IFN alpha-2a has low efficacy in advanced carcinoma of the penis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Penile Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Anemia / chemically induced. Disease Progression. Fatigue / chemically induced. Fever / chemically induced. Humans. Hypertriglyceridemia / chemically induced. Interferon-alpha / administration & dosage. Interferon-alpha / adverse effects. Isotretinoin / administration & dosage. Isotretinoin / adverse effects. Life Tables. Male. Middle Aged. Recombinant Proteins. Survival Analysis. Treatment Failure

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  • (PMID = 12643008.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA14958; United States / NCI NIH HHS / CA / CA21115; United States / NCI NIH HHS / CA / CA23318; United States / NCI NIH HHS / CA / CA32102; United States / NCI NIH HHS / CA / CA42777; United States / NCI NIH HHS / CA / CA49883; United States / NCI NIH HHS / CA / CA58882; United States / NCI NIH HHS / CA / CA66636; United States / NCI NIH HHS / CA / CACA21076
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon-alpha; 0 / Recombinant Proteins; 76543-88-9 / interferon alfa-2a; EH28UP18IF / Isotretinoin
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34. Petruzzi M, De Benedittis M, Pastore L, Grassi FR, Serpico R: Peno-gingival lichen planus. J Periodontol; 2005 Dec;76(12):2293-8
Hazardous Substances Data Bank. Clobetasol .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The prevalence, treatment options, and management for this condition are far from being established, and research in this area primarily relies on anecdotes.
  • Following careful examination of the oral and genital mucosae, pathology was obtained, previous treatments and duration of mucosal lesions ascertained, treatment initiated, and response evaluated at 8 weeks on both oral and genital lesions.
  • The first-line drug was topical clobetasol propionate 0.05% cream in all cases; in case of failure, topical cyclosporin was used.
  • A review of the literature on treatment options for this rare condition was performed based upon standard literature review practices.
  • Glans penis was involved in all patients.
  • All patients responded to treatment except for one.
  • A thorough multidisciplinary medical management and active early treatment are necessary to improve symptoms and prevent genital sequelae and, given the risk of squamous cell carcinoma, as a preventative strategy, although this area still needs investigation.
  • Therapeutic trials relating to the treatment of peno-gingival lichen planus may be undertaken considering that current management relies exclusively on observations of case reports.
  • [MeSH-major] Lichen Planus / diagnosis. Lichen Planus, Oral / diagnosis. Penile Diseases / diagnosis
  • [MeSH-minor] Administration, Topical. Adult. Anti-Inflammatory Agents / administration & dosage. Anti-Inflammatory Agents / therapeutic use. Candidiasis, Oral / etiology. Cheek / pathology. Clobetasol / administration & dosage. Clobetasol / analogs & derivatives. Clobetasol / therapeutic use. Cohort Studies. Follow-Up Studies. Gingival Diseases / diagnosis. Gingival Diseases / drug therapy. Glucocorticoids / administration & dosage. Glucocorticoids / therapeutic use. Humans. Lip Diseases / diagnosis. Lip Diseases / drug therapy. Male. Medical History Taking. Middle Aged. Remission Induction. Tongue Diseases / diagnosis. Tongue Diseases / drug therapy. Treatment Outcome

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  • [ErratumIn] J Periodontol. 2006 Feb;77(2):327
  • (PMID = 16332242.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Glucocorticoids; ADN79D536H / Clobetasol
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35. Riesz P, Nyirády P, Szucs M, Szendrôi A, Majoros A, Bánfi G, Kiss A, Lotz G, Törzsök P, Kelemen Z, Romics I: [Experiences in treatment and follow up of 50 patients with penile cancer]. Orv Hetil; 2007 Sep 16;148(37):1751-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Experiences in treatment and follow up of 50 patients with penile cancer].
  • INTRODUCTION: Malignant tumour of the penis is a rare disease.
  • Although most of the cases are squamous cell carcinoma histologically, operation is managed by the urologist because of its location.
  • AIM AND METHOD: Experience with the treatment and attendance of penile cancer is presented by the author.
  • Ninety-four percent of tumours were squamous cell carcinoma, 2 (4%) verrucosus carcinoma, in one case malignant melanoma.
  • In anamnesis 4 (8%) patients underwent circumcision because of phimosis, and 25 (50%) patients had had phimosis by identification of cancer.
  • Seventeen patients (34%) were given chemotherapy after surgical treatment.
  • Mean survival time of all patients was 31,4 (2-114) months.
  • CONCLUSION: Phimosis plays an important role in development of penile cancer, that's surgical treatment does not prevent the higher chance of incidence rate.
  • The disease behaves aggressively, spreading through lymphatic vessels, where in advanced stadium, or in low differentiation cases it is already demonstrable by diagnosis.
  • In the choice of therapy, stadium-oriented principle should be predominant.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Penile Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Verrucous / therapy. Chemotherapy, Adjuvant. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Melanoma / therapy. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17827084.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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36. Langeland T, Engh V: Topical use of tacrolimus and squamous cell carcinoma on the penis. Br J Dermatol; 2005 Jan;152(1):183-5
Genetic Alliance. consumer health - Carcinoma, Squamous Cell.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Topical use of tacrolimus and squamous cell carcinoma on the penis.
  • [MeSH-major] Carcinoma, Squamous Cell / chemically induced. Immunosuppressive Agents / adverse effects. Penile Neoplasms / chemically induced. Tacrolimus / adverse effects
  • [MeSH-minor] Balanitis / drug therapy. Humans. Male. Middle Aged

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  • [CommentOn] Br J Dermatol. 2003 Nov;149(5):960-7 [14632799.001]
  • (PMID = 15656830.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; WM0HAQ4WNM / Tacrolimus
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