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1. Kawaguchi T, Yamamoto S, Naka N, Okishio K, Atagi S, Ogawara M, Hosoe S, Kawahara M, Furuse K: Immunohistochemical analysis of Bcl-2 protein in early squamous cell carcinoma of the bronchus treated with photodynamic therapy. Br J Cancer; 2000 Jan;82(2):418-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical analysis of Bcl-2 protein in early squamous cell carcinoma of the bronchus treated with photodynamic therapy.
  • Photodynamic therapy (PDT) in early squamous cell carcinoma of the bronchus has been shown to result in complete response (CR) and cure.
  • From 1983 to 1997, 50 patients with 59 early squamous cell carcinoma of the bronchus received PDT, and a CR was obtained in 43 lesions (72.8%).
  • [MeSH-major] Bronchial Neoplasms / drug therapy. Carcinoma, Non-Small-Cell Lung / drug therapy. Carcinoma, Squamous Cell / drug therapy. Lung Neoplasms. Photochemotherapy. Proto-Oncogene Proteins c-bcl-2 / biosynthesis
  • [MeSH-minor] Aged. Female. Genes, p53 / genetics. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 10646898.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] SCOTLAND
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2
  • [Other-IDs] NLM/ PMC2363275
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2. Dudek AZ, Chereddy S, Nguyen S, Wagner JE, Maddaus M: Neoadjuvant chemotherapy with reduced-dose carboplatin and gemcitabine for non-small cell lung cancer in a patient with Fanconi anemia. J Thorac Oncol; 2008 Apr;3(4):447-50
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  • [Title] Neoadjuvant chemotherapy with reduced-dose carboplatin and gemcitabine for non-small cell lung cancer in a patient with Fanconi anemia.
  • Fourteen years later, he presented with squamous cell carcinoma of the bronchus intermedius in the right lung.
  • Two cycles of neoadjuvant therapy were given in an attempt to decrease tumor size and avoid a potential right pneumonectomy.
  • Treatment consisted of a 21-day cycle with carboplatin (area under the curve 3) given on day 1 and gemcitabine (1250 mg/m) on day 1 and 8.
  • Because FA cells are hypersensitive to DNA crosslinking agents, we reduced the carboplatin dose to minimize treatment-related toxicity.
  • In our case, neoadjuvant therapy with gemcitabine and low-dose carboplatin exhibited antitumor activity with manageable side-effects, suggesting that this chemotherapy regimen can be safely and effectively used in the treatment of NSCLC in FA patients who have achieved hematopoietic reconstitution after bone marrow transplantation.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Fanconi Anemia / therapy. Neoadjuvant Therapy
  • [MeSH-minor] Adult. Bone Marrow Transplantation. Bronchial Neoplasms / drug therapy. Bronchial Neoplasms / etiology. Bronchoscopy. Carboplatin / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / etiology. Chemotherapy, Adjuvant. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / etiology. Male. Pulmonary Artery / pathology. Pulmonary Artery / radiation effects. Whole-Body Irradiation

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  • (PMID = 18379369.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin
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3. Hirasaki S, Suzuki S, Umemura S, Kamei H, Okuda M, Kudo K: Asymptomatic colonic metastases from primary squamous cell carcinoma of the lung with a positive fecal occult blood test. World J Gastroenterol; 2008 Sep 21;14(35):5481-3
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  • [Title] Asymptomatic colonic metastases from primary squamous cell carcinoma of the lung with a positive fecal occult blood test.
  • We describe a 74-year-old man with a colonic metastatic squamous cell carcinoma (SCC) from the lung.
  • Computed tomography (CT) of the chest demonstrated a large lung tumor in the right upper lobe obstructing the right upper bronchus.
  • Bronchoscopy revealed an easy-bleeding tumor in the right upper bronchus that was diagnosed as poorly differentiated squamous cell lung carcinoma.
  • Histological examination of the biopsy specimen obtained from the colonic lesion revealed SCC.
  • The lesion was diagnosed as metastatic colonic SCC.
  • He underwent chemotherapy with an infusion of cisplatin 130 mg i.v. day 1, and docetaxel hydrate 100 mg i.v. day 1, repeated every 4 wk, followed by 4 courses of chemotherapy.
  • The primary lesion shrank by less than 10% and was judged to be "Partial Response" (PR) after 3 courses of treatment.
  • The patient still lived 23 wk after the diagnosis of metastatic colonic SCC.
  • Colonic metastasis of primary SCC of the lung is rare.
  • [MeSH-major] Carcinoma, Small Cell / secondary. Colonic Neoplasms / secondary. Lung Neoplasms

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  • (PMID = 18803365.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2744902
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4. Gika M, Takeuchi K, Takanami I: Successful management of a patient with stage IIIA non-small cell lung cancer using sensitivity-based induction chemotherapy--report of a case. Gan To Kagaku Ryoho; 2004 Nov;31(12):2055-8
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  • [Title] Successful management of a patient with stage IIIA non-small cell lung cancer using sensitivity-based induction chemotherapy--report of a case.
  • To select the most appropriate drug treatment for different patients with lung cancer, we have been measuring the chemosensitivity of lung cancer tissues to various drugs using the collagen gel droplet embedded culture drug sensitivity test (CD-DST).
  • A 57-year-old Japanese male with stage IIA squamous cell carcinoma of the lung received sensitivity-based induction chemotherapy consisting of docetaxel (70 mg/m2) given on days 1, 22, and 43.
  • After the chemotherapy, the left upper bronchus was reopened by the reduction of the tumor, and a left pneumonectomy with simultaneous partial resection of the pericardium was performed.
  • After discharge, the patient received 2 cycles of adjuvant chemotherapy, consisting of weekly docetaxel doses (35 mg/m2) for 3 consecutive weeks, followed by one week without treatment.
  • Although the 3-year survival rate of stage IIIA NSCLC patients is under 30%, three years after administration of the chemotherapy no other recurrence site has been detected, and the patient is in good health.
  • Using CD-DST, sensitivity-based induction chemotherapy with docetaxel was successful in the patient reported here.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy. Taxoids / therapeutic use
  • [MeSH-minor] Chemotherapy, Adjuvant. Drug Screening Assays, Antitumor. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 15570940.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Taxoids; 15H5577CQD / docetaxel
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5. Van Denhove A, Freymond N, Isaac S, Marrou K, Balme B, Gormand F, Guibert B, Pacheco Y, Devouassoux G: [Sweet's syndrome associated with squamous cell bronchial carcinoma. Neutrophilic dermatosis and non-small cell lung cancer]. Rev Mal Respir; 2007 Jan;24(1):77-80
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  • [Title] [Sweet's syndrome associated with squamous cell bronchial carcinoma. Neutrophilic dermatosis and non-small cell lung cancer].
  • [Transliterated title] Syndrome de Sweet révélant un carcinome bronchique épidermoïde. Cancer bronchique et dermatose neutrophilique.
  • An association with carcinoma of the bronchus has been only rarely described.
  • CASE REPORT: We report the case of a 56 year old man who presented with Sweet's syndrome two months before the diagnosis of a squamous cell carcinoma of the bronchus.
  • The progress of the tumour was favourable, with stabilisation following 3 courses of chemotherapy and local radiotherapy.
  • [MeSH-major] Bronchial Neoplasms / complications. Carcinoma, Non-Small-Cell Lung / complications. Carcinoma, Squamous Cell / complications. Lung Neoplasms / complications. Paraneoplastic Syndromes / etiology. Sweet Syndrome / etiology


6. Old SE, Gilligan D, Balan KK, Coulden RA: Complete pathological response to chemotherapy for non-small cell lung cancer demonstrated by gamma camera positron emission tomography. Clin Oncol (R Coll Radiol); 2000;12(1):53-5
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  • [Title] Complete pathological response to chemotherapy for non-small cell lung cancer demonstrated by gamma camera positron emission tomography.
  • We report the case history of a 61-year-old female smoker who presented with an inoperable T2N2M0 squamous cell carcinoma of the right upper lobe bronchus.
  • This was staged by computed tomography (CT), positron emission tomography (PET) using a modified dual-headed gamma camera, and mediastinoscopy.
  • She then underwent three cycles of cisplatin-containing chemotherapy.
  • After the chemotherapy, CT demonstrated a residual 10 mm mass in the right upper lobe and a considerable reduction in size of the mediastinal lymphadenopathy.
  • We discuss PET, the potential new applications of gamma camera technology, and the use of cisplatin-containing chemotherapy in non-small cell lung cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy. Tomography, Emission-Computed, Single-Photon / methods
  • [MeSH-minor] Cisplatin / administration & dosage. Female. Humans. Middle Aged. Neoplasm Staging / methods. Radiography. Treatment Outcome

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  • (PMID = 10749021.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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7. Kobashi Y, Okimoto N, Sakamoto K: Squamous cell carcinoma of the lung producing granulocyte colony-stimulating factor and resembling a malignant pleural mesothelioma. Intern Med; 2004 Feb;43(2):111-6
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  • [Title] Squamous cell carcinoma of the lung producing granulocyte colony-stimulating factor and resembling a malignant pleural mesothelioma.
  • A 65-year-old was admitted to our hospital and was diagnosed as having squamous cell carcinoma originating in the right upper bronchus.
  • He underwent both chemotherapy and radiation therapy, but these therapies were ineffective and thereafter the developed radiation pneumonitis and carcinomatous pleuritis.
  • Finally, he died of bacterial pneumonia in the opposite normal lung of four months duration.
  • At autopsy, squamous cell carcinoma was found in the right hilus region of the lung, with a spreading form resembling a malignant pleural mesothelioma mainly occupying the pleural cavity.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secretion. Granulocyte Colony-Stimulating Factor / biosynthesis. Leukocytosis / etiology. Lung Neoplasms / diagnosis. Lung Neoplasms / secretion. Mesothelioma / diagnosis. Pleural Neoplasms / diagnosis
  • [MeSH-minor] Aged. Bronchoscopy. Fatal Outcome. Humans. Male. Radiation Pneumonitis / radiography. Tomography, X-Ray Computed

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  • (PMID = 15005252.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor
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8. Boutemy M, Mispelaere D, Krzisch C, Jounieaux V: [Evaluation of combined chemotherapy with vinorelbine, ifosfamide and cisplatin in the treatment of metastatic non-small cell bronchial carcinoma]. Rev Mal Respir; 2005 Jun;22(3):413-9
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  • [Title] [Evaluation of combined chemotherapy with vinorelbine, ifosfamide and cisplatin in the treatment of metastatic non-small cell bronchial carcinoma].
  • [Transliterated title] Evaluation de la chimiothérapie associant vinorelbine-ifosfamide-cisplatine dans le traitement des cancers bronchiques non à petites cellules métastatiques.
  • INTRODUCTION: In France, cancer of the bronchus is responsible for 25,000 deaths per year.
  • Non small cell lung cancer (NSCLC) represents 80% of bronchial carcinoma of which 40-50% are mefastatic at the time of diagnosis.
  • At present, although the therapeutic benefits are modest, it is now recognised that combination chemotherapy including platinum salts improves the survival of these patients.
  • METHODS: We analysed retrospectively a cohort of 57 patients suffering from stage IV NSCLC treated with chemotherapy combining cisplatin (80 mg/rn2 on day 1), vinorelbine (25 mg/rn2 on days 1 and 8) and ifosfamide (3000 mg/in 2 on day 1), (NIP), repeated every 21 days.
  • All patients were studied in terms of toxicity and overall survival but only 40 (70%) were able to be evaluated in terms of response to treatment (on account of having received more than three cycles of NIP chemotherapy).
  • For the 40 patients for whom chemotherapy was evaluable, the objective response rate was 20%.
  • CONCLUSION: Treatment of stage IV NSCLC with NIP chemotherapy is effective and improves the survival of these patients independently of other prognostic factors such as age, the presence of cerebral metastases, performance status, histological type, the number of metastatic sites or the serum LOH level.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / drug therapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Adult. Aged. Brain Neoplasms / drug therapy. Brain Neoplasms / secondary. Carcinoma, Bronchogenic / drug therapy. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / secondary. Cisplatin / administration & dosage. Cisplatin / adverse effects. Cohort Studies. Female. Gastrointestinal Diseases / chemically induced. Hematologic Diseases / chemically induced. Humans. Ifosfamide / administration & dosage. Ifosfamide / adverse effects. Life Tables. Male. Middle Aged. Retrospective Studies. Smoking / adverse effects. Survival Analysis. Treatment Outcome. Vinblastine / administration & dosage. Vinblastine / adverse effects. Vinblastine / analogs & derivatives

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  • (PMID = 16227927.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; Q6C979R91Y / vinorelbine; UM20QQM95Y / Ifosfamide
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9. Orski J, Telesińska D, Curyło A, Grodzicki T: [Cardiac tamponade as the first clinical manifestation of squamous cell carcinoma]. Przegl Lek; 2002;59(2):121-4
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  • [Title] [Cardiac tamponade as the first clinical manifestation of squamous cell carcinoma].
  • The case concerns a 56 year old male with the diagnosis of squamous cell carcinoma, which clinically presented as a rapidly increasing cardiac tamponade.
  • Due to the expansion of the process within the bronchus, the patient underwent chemotherapy according to the Taxol + Carboplatine scheme.
  • After 8 months of treatment the patient was hospitalized again due to a further increase in fluid in the pericardium, and symptoms of cardiac insufficiency which lead to patient death.
  • Squamous cell carcinoma metastases may be the cause of pericardial effusion, which is associated with poor prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / diagnosis. Cardiac Tamponade / etiology. Heart Neoplasms / complications. Heart Neoplasms / diagnosis. Pericardium
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Autopsy. Carboplatin / administration & dosage. Diagnosis, Differential. Fatal Outcome. Humans. Male. Middle Aged. Paclitaxel / administration & dosage

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  • (PMID = 12152250.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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10. Takemura M, Osugi H, Lee S, Taguchi S, Kaneko M, Tanaka Y, Fukuhara K, Fujiwara Y, Nishizawa S, Kinoshita H: [Resection of esophageal cancer infiltrating the left main bronchus following complete response to preoperative radiochemotherapy--a case report]. Gan To Kagaku Ryoho; 2003 Nov;30(12):1949-53
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  • [Title] [Resection of esophageal cancer infiltrating the left main bronchus following complete response to preoperative radiochemotherapy--a case report].
  • We report a case of esophageal cancer infiltrating the left main bronchus in which radical esophagectomy with clear surgical margins could be performed after preoperative radiochemotherapy.
  • The patient was a 57-year-old man, who was found to have esophageal squamous cell carcinoma of the middle thoracic esophagus during a work-up of dysphagia.
  • Bronchoscopy revealed an elevated region protruding into the lumen of the left main bronchus.
  • After radiochemotherapy (liniac irradiation + low-dose FP therapy), the esophageal and bronchial lesion became smaller.
  • It is necessary to verify the effectiveness of surgical resection, as a secondary treatment, by accumulating data on cases such as the present one.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bronchial Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / radiotherapy. Esophagectomy
  • [MeSH-minor] Cisplatin / administration & dosage. Dose-Response Relationship, Drug. Drug Administration Schedule. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Invasiveness. Radiotherapy Dosage

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  • (PMID = 14650965.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; CF regimen
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11. Hosoya Y, Lefor A, Hirashima Y, Nokubi M, Yamaguti T, Jinbu Y, Muroi K, Nakazawa M, Yasuda Y: Successful treatment of esophageal squamous cell carcinoma in a patient with Fanconi anemia. Jpn J Clin Oncol; 2010 Aug;40(8):805-10
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  • [Title] Successful treatment of esophageal squamous cell carcinoma in a patient with Fanconi anemia.
  • Esophageal cancer developed at age 35.
  • Invasion of the bronchus and aorta by the tumor was suspected on computed tomography.
  • After two courses of chemotherapy with cisplatin (total dose, 100 mg) and 5-fluorouracil (5000 mg) plus radiotherapy (30 Gy), Grade 3 diarrhea and bone marrow suppression developed, and treatment was discontinued.
  • After resolution of toxicity, a good response to the neoadjuvant therapy was seen on computed tomography scan, and a subtotal esophagectomy was performed which demonstrated a complete response in the resected specimen.
  • However, tongue cancer developed at age 40 years, and hemiglossectomy was performed.
  • However, the optimal dosage of chemoradiotherapy and the treatment strategy for esophageal cancer in patients with Fanconi anemia remain unclear, and outcomes are generally extremely poor.
  • In this patient, esophageal cancer associated with Fanconi anemia responded well to multidisciplinary therapy.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Esophageal Neoplasms / therapy. Fanconi Anemia / complications
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Bone Marrow Transplantation. Child. Cisplatin / administration & dosage. Combined Modality Therapy. Esophagectomy. Female. Fluorouracil / administration & dosage. Humans. Neoplasm Staging. Radiotherapy Dosage. Tomography, X-Ray Computed. Tongue Neoplasms / pathology. Tongue Neoplasms / secondary


12. Katsuragi N, Shiraishi Y, Kita H, Hashizume M, Miyasaka Y, Tanaka S: [21-year-old man with squamous cell carcinoma of the lung]. Kyobu Geka; 2007 Jul;60(7):529-32
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  • [Title] [21-year-old man with squamous cell carcinoma of the lung].
  • Lung cancer among people in their twenties is rare and accounts for only 0.1-0.4% of all cases.
  • We describe a case of squamous cell carcinoma of the lung in a 21-year-old man.
  • Computed tomography also showed a 3 cm hilar lymph node.
  • Bronchoscopy revealed a white polypoid mass obstructing the right basal bronchus.
  • Transbronchial biopsy revealed poorly differentiated squamous cell carcinoma of the lung.
  • Clinical diagnosis was T2N1M0, stage IIB lung cancer.
  • Pathological diagnosis was T2N2M0, stage IIIA lung cancer.
  • He received 3 rounds of chemotherapy with cisplatin and docetaxel and irradiation to the right hilum and mediastinum at a total dose of 60 Gy in 30 fractions.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Humans. Lymph Node Excision. Male. Pneumonectomy. Radiotherapy, Adjuvant

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  • (PMID = 17642212.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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13. Ananian P, Doddoli C, Barlési F, Grégoire E, Aragon A, Giudicelli R, Thomas P: Venobronchial fistula: an unusual complication of long-term central venous access. Respiration; 2006;73(5):686-9
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  • A venobronchial fistula developed between the azygous vein and the upper aspect of the right main bronchus 12 months after completion of the treatment of a stage IIIB non-small-cell lung cancer in a 54-year-old man.
  • The fistula contained the tip of the catheter placed for chemotherapy perfusion.
  • [MeSH-major] Azygos Vein. Bronchial Fistula / etiology. Carcinoma, Non-Small-Cell Lung / complications. Catheterization, Central Venous / adverse effects. Lung Neoplasms / complications. Vascular Fistula / etiology
  • [MeSH-minor] Antineoplastic Agents / administration & dosage. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / surgery. Catheters, Indwelling / adverse effects. Humans. Lymphatic Metastasis / pathology. Male. Mediastinal Neoplasms / complications. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / surgery. Middle Aged. Postoperative Complications / etiology

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  • (PMID = 16106107.001).
  • [ISSN] 0025-7931
  • [Journal-full-title] Respiration; international review of thoracic diseases
  • [ISO-abbreviation] Respiration
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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14. Morbini P, Riboni R, Tomaselli S, Rossi A, Magrini U: Eber- and LMP-1-expressing pulmonary lymphoepithelioma-like carcinoma in a Caucasian patient. Hum Pathol; 2003 Jun;34(6):623-5
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  • [Title] Eber- and LMP-1-expressing pulmonary lymphoepithelioma-like carcinoma in a Caucasian patient.
  • Primary lymphoepithelioma-like carcinoma (LELC) of the lung is a rare tumor that preferentially affects Asian patients, with only 15 cases described in Caucasians to date.
  • Epstein-Barr virus (EBV) infection is present in most lung LELCs in Asians, but it has never been shown in Caucasians.
  • EBV small nuclear RNA and latent membrane protein-1 were identified in the neoplastic cells of primary LELC of the lung diagnosed by endobronchial biopsy in a 25-year-old Italian male.
  • Despite advanced locoregional disease, with neoplastic infiltration of the main right bronchus, the carina, and the pulmonary artery, which prevented surgical resection, partial response and 1-year symptom-free follow-up were achieved after combined chemotherapy and radiotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Epstein-Barr Virus Infections / metabolism. Herpesvirus 4, Human / isolation & purification. Lung Neoplasms / metabolism. RNA-Binding Proteins / metabolism. Ribosomal Proteins. Viral Matrix Proteins / metabolism
  • [MeSH-minor] Adult. Antigens, Viral / analysis. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor. Cell Nucleus / metabolism. Cell Nucleus / pathology. Cell Nucleus / virology. Combined Modality Therapy. Humans. Immunohistochemistry. Male. Neoplasm Staging. Palliative Care. Radiotherapy. Treatment Outcome

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  • (PMID = 12827618.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / RNA-Binding Proteins; 0 / Ribosomal Proteins; 0 / Viral Matrix Proteins; 135844-68-7 / RPL22 protein, human
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15. Taniguchi Y, Horio H, Suzuki Y, Nakamura H: Bronchoplastic lobectomy with wide wedge resection for lung cancer with long-term steroid medication. Ann Thorac Cardiovasc Surg; 2007 Dec;13(6):403-6
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  • [Title] Bronchoplastic lobectomy with wide wedge resection for lung cancer with long-term steroid medication.
  • A 57-year-old man with erythrodermia, who was given 5-10 mg/day of prednisolone for 2.5 years, was admitted to our hospital for squamous cell lung carcinoma of the right upper lobe.
  • A bronchoscopy revealed a tumor nearly obstructing the right upper lobe bronchus.
  • A bronchoplastic lobectomy was performed with wide wedge resection of the main bronchus and truncus intermedius.
  • A postoperative bronchoscopy revealed good healing of the anastomosis and a 3-dimensional construction of the bronchus with chest computed tomography demonstrated no stenotic change and no kinking change in the anastomosis.
  • Bronchoplastic lobectomy with wide wedge resection is a useful procedure in cases with risk factors of anastomotic dehiscence, such as after induction therapy or during long-term administration of adrenal cortical steroids.
  • [MeSH-major] Dermatitis, Exfoliative / drug therapy. Lung Neoplasms / surgery. Pneumonectomy / methods

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  • (PMID = 18292724.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Glucocorticoids; 9PHQ9Y1OLM / Prednisolone
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16. Peled N, Flex D, Raviv Y, Fox BD, Shitrit D, Refaeli Y, Sauté M, Amital A, Kramer MR: The role of routine bronchoscopy for early detection of bronchial stump recurrence of lung cancer: 1 year post-surgery. Lung Cancer; 2009 Sep;65(3):319-23
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  • [Title] The role of routine bronchoscopy for early detection of bronchial stump recurrence of lung cancer: 1 year post-surgery.
  • This study focuses on early detection of stump recurrence by a routine bronchoscopy.
  • Four of the nine polyps were malignant.
  • Nine other patients had squamous metaplasia and two had squamous dysplasia.
  • Malignant stump recurrence was observed in four cases, all had a stump polyp.
  • Fisher exact analysis showed short bronchus (p=0.003), N2 vs. N0-1 (p=0.012), and N1 vs. N0 (p=0.011) as significant risk factor for stump recurrence.
  • For stump recurrence, one patient underwent completion pneumonectomy and has no evidence for disease (32.2 months), two patients were treated by chemotherapy and one patient died from pneumonia before therapy.
  • [MeSH-major] Bronchoscopy. Carcinoma, Non-Small-Cell Lung / diagnosis. Early Diagnosis. Lung Neoplasms / diagnosis. Neoplasm, Residual / diagnosis
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Pneumonectomy. Polyps. Prospective Studies. Risk Factors

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  • (PMID = 19144443.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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17. Saito M, Furukawa K, Miura T, Kato H: Evaluation of T factor, surgical method, and prognostic factors in central type lung cancer. Jpn J Thorac Cardiovasc Surg; 2002 Oct;50(10):413-7
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  • [Title] Evaluation of T factor, surgical method, and prognostic factors in central type lung cancer.
  • OBJECTIVE: We report our experience in the diagnosis and surgical treatment of central type lung cancer (CTLC) and discuss the prognostic significance of clinicopathological factors including the T factor.
  • Data on CTLC was compared to that on peripheral lung cancer during the same period.
  • RESULTS: Compared to peripheral tumors, central lung tumors showed a higher ratio in male gender, pN1 in pN factors, squamous cell carcinoma in histology, and pneumonectomy and bronchoplasty in surgery.
  • No significant difference was seen in 5-year survival based on 8 factors--period, cT factors, tumor histology, bronchoplasty, extended surgery, cellular atypia, additional chemotherapy, and radiotherapy.
  • CONCLUSIONS: CTLC appears to belong to a subgroup other than peripheral tumors, requiring a more accurate diagnosis of cT factors, particularly in the proximal bronchus, because cT and cN factors are the only 2 used preoperatively.
  • [MeSH-major] Lung Neoplasms / surgery
  • [MeSH-minor] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged. Pneumonectomy. Prognosis

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  • (PMID = 12428380.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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18. Riquet M, Lang-Lazdunski L, Le PB, Dujon A, Souilamas R, Danel C, Manac'h D: Characteristics and prognosis of resected T3 non-small cell lung cancer. Ann Thorac Surg; 2002 Jan;73(1):253-8
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  • [Title] Characteristics and prognosis of resected T3 non-small cell lung cancer.
  • BACKGROUND: T3 tumors can be divided into several subgroups depending on the type of anatomical structure invaded: chest wall, mediastinal pleura, or main bronchus.
  • METHODS: The results of surgical treatment were retrospectively analyzed for 261 patients with T3 non-small cell lung cancer invading either the mediastinal pleura or parietal pericardium by direct extension (mediastinal pT3, n = 68), or main bronchus (bronchial pT3, n = 68), or chest wall (chest wall pT3, n = 125) that were operated on between 1984 and 1996.
  • One hundred and fifty-eight patients received adjuvant radiation therapy and 7 patients received both adjuvant chemotherapy and radiation therapy.
  • Histology, type of surgical resection (lobectomy versus pneumonectomy), and use of adjuvant therapy did not influence survival significantly.
  • CONCLUSIONS: Five-year survival was not significantly different among the three subgroups of pT3 non-small cell lung cancer, although bronchial pT3 tumors tended to have a better prognosis and chest wall pT3 tumors tended to have a worse prognosis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / mortality. Lung Neoplasms / mortality
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Chemotherapy, Adjuvant. Female. Hospital Mortality. Humans. Lymph Node Excision. Male. Middle Aged. Neoplasm Staging. Pneumonectomy. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis

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  • (PMID = 11834019.001).
  • [ISSN] 0003-4975
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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19. Sonobe M, Nakagawa M, Ichinose M, Ikegami N, Nagasawa M, Shindo T: Analysis of risk factors in bronchopleural fistula after pulmonary resection for primary lung cancer. Eur J Cardiothorac Surg; 2000 Nov;18(5):519-23
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  • [Title] Analysis of risk factors in bronchopleural fistula after pulmonary resection for primary lung cancer.
  • We studied the risk factors for BPF formation after lung cancer operation to clarify the indication of preventive bronchial stump coverage.
  • METHODS: We reviewed 557 consecutive bronchial stumps, corresponding to 547 patients without any coverage in pulmonary resection for lung cancer between 1989 and 1998.
  • RESULTS: BPFs developed in ten patients (1.8%).
  • Compared with the lobar bronchus (LB), the main bronchus (MB; P<0.01; odds ratio, 23.0) and the intermediate bronchus (IB; P=0.03; odds ratio, 10.7) carried a high risk.
  • Previous ipsilateral thoracotomy (P<0.01; odds ratio, 37.9) and preoperative chemotherapy and/or radiotherapy (P=0.02; odds ratio, 13.2) increased the risk.
  • The incidence of BPFs with manual suture, stapling devices only, reinforcement suture at the distal side of staplers, or reinforcement suture at the proximal side of staplers was 1.8, 5.0, 1.9 and 1.0%, respectively.
  • CONCLUSIONS: The main and intermediate bronchial stumps, and the stumps in cases with previous ipsilateral thoracotomy or receiving induction therapy are prone to BPFs.
  • [MeSH-major] Adenocarcinoma / surgery. Bronchial Fistula / etiology. Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Pleural Diseases / etiology. Pneumonectomy / adverse effects. Respiratory Tract Fistula / etiology. Surgical Stapling / methods. Suture Techniques
  • [MeSH-minor] Aged. Aged, 80 and over. Chi-Square Distribution. Combined Modality Therapy. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Odds Ratio. Retrospective Studies. Risk Factors. Treatment Outcome. Wound Healing

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  • (PMID = 11053810.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
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20. Kosaba S, Yamamoto K: [Carinal reconstruction with wide airway resection by a new technique]. Kyobu Geka; 2001 Jan;54(1):4-7
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  • A 61-year man with tracheal stenosis by tracheal cancer, 6 tracheal rings, 2 left bronchial rings, total right main bronchus, for which carina was resected and reconstructed by a new technique and for a 69 year man with lung cancer in right upper lobe, for which right upper-middle bilobectomy, S6 segmental resection and circumferential pulmonary artery resection were performed.
  • The tracea, left main bronchus, and right basal segment bronchus were anastomosed by new technique and the right main pulmonary artery and basal segment artery was anastomosed subsequent to chemotherapy.
  • The new reconstructive method of carina permits simple anastomosis, the possibility of carina reconstruction even in the case of wide airway resection and loss tension at the site of anastomosis.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Neoplasms, Multiple Primary / surgery. Reconstructive Surgical Procedures / methods. Trachea / surgery. Tracheal Neoplasms / surgery
  • [MeSH-minor] Aged. Anastomosis, Surgical / methods. Humans. Lung Neoplasms / surgery. Male. Middle Aged. Neoplasm Invasiveness. Pneumonectomy. Treatment Outcome

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  • (PMID = 11197908.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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