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2. Ishibashi S, Yokota T, Inaba A, Yamada M, Mizusawa H, Iwai T, Shiojiri T: Mexiletine is effective on segmental hyperhidrosis: report of two cases. J Neurol Neurosurg Psychiatry; 2002 Jan;72(1):122

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Hyperhidrosis / drug therapy. Mexiletine / therapeutic use
  • [MeSH-minor] Administration, Oral. Adult. Female. Hemangioma, Cavernous / complications. Humans. Male. Middle Aged. Spinal Cord Neoplasms / complications. Syringomyelia / complications. Treatment Outcome

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  • [CommentIn] J Neurol Neurosurg Psychiatry. 2002 Sep;73(3):351; author reply 351 [12185188.001]
  • (PMID = 11784840.001).
  • [ISSN] 0022-3050
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 1U511HHV4Z / Mexiletine
  • [Other-IDs] NLM/ PMC1737711
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3. Fulkerson DH, Agim NG, Al-Shamy G, Metry DW, Izaddoost SA, Jea A: Emergent medical and surgical management of mediastinal infantile hemangioma with symptomatic spinal cord compression: case report and literature review. Childs Nerv Syst; 2010 Dec;26(12):1799-805
Hazardous Substances Data Bank. HEPARIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Emergent medical and surgical management of mediastinal infantile hemangioma with symptomatic spinal cord compression: case report and literature review.
  • PURPOSE: We report an extremely rare case of a patient with a large, cervical, and upper thoracic cutaneous hemangioma associated with a separate, underlying mediastinal hemangioma extending to the epidural space causing significant spinal cord compression.
  • She underwent emergent surgical decompression and medical therapy with propranolol and systemic corticosteroids.
  • CONCLUSION: While several recent reports have described dramatic responses of hemangiomas to propranolol, this is the first case in which it was used as part of a multimodal approach to symptomatic spinal cord compression.
  • [MeSH-major] Decompression, Surgical / adverse effects. Hemangioma, Capillary / drug therapy. Hemangioma, Capillary / surgery. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / surgery. Spinal Cord Compression / surgery
  • [MeSH-minor] Adrenergic beta-Antagonists / therapeutic use. Anti-Inflammatory Agents / therapeutic use. Anticoagulants / therapeutic use. Child, Preschool. Female. Heparin / therapeutic use. Humans. Postoperative Complications / drug therapy. Postoperative Complications / etiology. Prednisolone / therapeutic use. Propranolol / therapeutic use. Venous Thrombosis / drug therapy. Venous Thrombosis / etiology

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  • Hazardous Substances Data Bank. PROPRANOLOL HYDROCHLORIDE .
  • Hazardous Substances Data Bank. PREDNISOLONE .
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  • (PMID = 20405131.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Anti-Inflammatory Agents; 0 / Anticoagulants; 9005-49-6 / Heparin; 9PHQ9Y1OLM / Prednisolone; 9Y8NXQ24VQ / Propranolol
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4. Abejón D, del Saz JM, Ley L, Sánchez MR, del Pozo C: [Spinal granuloma in a patient receiving a spinal infusion of morphine and clonidine]. Rev Esp Anestesiol Reanim; 2009 Jun-Jul;56(6):380-4
Hazardous Substances Data Bank. MORPHINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spinal granuloma in a patient receiving a spinal infusion of morphine and clonidine].
  • [Transliterated title] Granuloma intradural en un paciente con infusión espinal de morfina y clonidina.
  • Patients treated with long-term spinal infusion of high doses of morphine develop a granuloma at the location of the catheter tip.
  • Diagnosis is based on a steady increase in intrathecal morphine dosage after a relatively prolonged period of stability, on the gradual development of neurologic signs and symptoms suggesting radicular or spinal cord compression, and on magnetic resonance images.
  • The presence of all 3 of the aforementioned diagnostic criteria led to suspicion of a spinal granuloma.
  • [MeSH-major] Analgesia, Epidural / instrumentation. Analgesics, Opioid / therapeutic use. Back Pain / etiology. Catheterization / adverse effects. Clonidine / therapeutic use. Granuloma, Foreign-Body / etiology. Infusion Pumps, Implantable / adverse effects. Morphine / therapeutic use. Muscle Relaxants, Central / therapeutic use. Neuralgia / etiology. Postoperative Complications / etiology. Spinal Cord Compression / etiology
  • [MeSH-minor] Drug Therapy, Combination. Emergencies. Hemangioma, Cavernous, Central Nervous System / surgery. Humans. Infusions, Parenteral / instrumentation. Laminectomy. Male. Middle Aged. Spinal Cord Diseases / surgery

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  • Hazardous Substances Data Bank. CLONIDINE .
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  • (PMID = 19725346.001).
  • [ISSN] 0034-9356
  • [Journal-full-title] Revista española de anestesiología y reanimación
  • [ISO-abbreviation] Rev Esp Anestesiol Reanim
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Muscle Relaxants, Central; 76I7G6D29C / Morphine; MN3L5RMN02 / Clonidine
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5. Soeda A, Sakai N, Iihara K, Nagata I: Cobb syndrome in an infant: treatment with endovascular embolization and corticosteroid therapy: case report. Neurosurgery; 2003 Mar;52(3):711-5; discussion 714-5
Hazardous Substances Data Bank. PREDNISOLONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cobb syndrome in an infant: treatment with endovascular embolization and corticosteroid therapy: case report.
  • OBJECTIVE AND IMPORTANCE: Cobb syndrome is a rare clinical entity characterized by the combination of a vascular skin nevus and an angioma in the spinal canal at the same metamere.
  • CLINICAL PRESENTATION: A 5-month-old girl presented with cutaneous hemangioma of the thoracolumbar region (T5-T12) and paraparesis.
  • INTERVENTION: The patient received orally administered prednisolone therapy and underwent endovascular embolization of paravertebral and spinal angiomas with the use of n-butyl-2-cyanoacrylate.
  • Her symptoms improved by combined treatment with liquid embolization and corticosteroid therapy.
  • To our knowledge, this is the first report of an infant with Cobb syndrome treated with endovascular embolization and corticosteroid therapy.
  • The combined treatment with corticosteroid therapy and endovascular embolization of cutaneomeningospinal angioma in Cobb syndrome seems effective in alleviating symptoms and minimizing morbidity.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Embolization, Therapeutic. Hemangioma / complications. Hemangioma / therapy. Nevus / complications. Nevus / therapy. Prednisolone / therapeutic use. Skin Neoplasms / complications. Skin Neoplasms / therapy. Spinal Canal / drug effects. Spinal Canal / surgery. Spinal Neoplasms / complications. Spinal Neoplasms / therapy

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  • (PMID = 12590699.001).
  • [ISSN] 0148-396X
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 9PHQ9Y1OLM / Prednisolone
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6. Guzey FK, Emel E, Aycan A, Bas NS, Seyithanoglu MH, Ozkan N, Karabulut C: Pediatric vertebral and spinal epidural tumors: a retrospective review of twelve cases. Pediatr Neurosurg; 2008;44(1):14-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric vertebral and spinal epidural tumors: a retrospective review of twelve cases.
  • We aimed to report the clinical, radiological and pathological characteristics in a small series of pediatric vertebral and spinal epidural tumors and to discuss diagnostic and treatment difficulties.
  • MATERIALS AND METHODS: Twelve consecutive pediatric cases with vertebral or spinal epidural tumors were reviewed retrospectively.
  • Three patients with malignant tumors were treated by radiotherapy and 2 by chemotherapy.
  • One patient with thoracic hemangioma was also treated by embolization after surgery.
  • There were no new spinal deformities on follow-up.
  • CONCLUSION: Children with vertebral tumors and spinal epidural tumors usually present with pain and neurological deficits or local findings, and there are some indications on plain radiographs.
  • [MeSH-major] Epidural Neoplasms / diagnosis. Epidural Neoplasms / therapy. Spinal Neoplasms / diagnosis. Spinal Neoplasms / therapy

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18097186.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 17
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7. Rand T, Lomoschitz F, Cejna M, Grohs A, Kettenbach J: [Percutaneous radiologically-guided vertebroplasty in the treatment of osteoporotic and tumorous spinal body lesions]. Radiologe; 2003 Sep;43(9):723-8
MedlinePlus Health Information. consumer health - Spine Injuries and Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Percutaneous radiologically-guided vertebroplasty in the treatment of osteoporotic and tumorous spinal body lesions].
  • [Transliterated title] Perkutane, radiologisch gesteuerte Vertebroplastie zur Therapie osteoporotischer und tumoröser Wirbelkörperläsionen.
  • Main indications are the treatment of osteoporotic vertebral body fractures, however also the treatment of tumorous lesions becomes more and more established.
  • The indication for vertebroplasty of tumorous lesions is therapy-refractory pain in symptomatic hemangiomas, metastases and myelomas.
  • By minimal invasive therapy stabilization of vertebral bodies and pain reduction may be achieved.
  • [MeSH-major] Kyphosis / surgery. Orthopedic Procedures / methods. Osteoporosis / complications. Spinal Fractures / surgery. Spinal Neoplasms / complications. Thoracic Vertebrae / surgery. Tomography, X-Ray Computed
  • [MeSH-minor] Bone Cements. Fluoroscopy. Follow-Up Studies. Hemangioma / complications. Humans. Pain / drug therapy. Pain / etiology. Pain / prevention & control. Plasmacytoma / complications. Risk Factors. Time Factors. Treatment Outcome

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  • (PMID = 14517602.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
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8. Yadav N, Prabhakar H, Singh GP, Bindra A, Ali Z, Bithal PK: Acute hemodynamic instability during alcohol ablation of symptomatic vertebral hemangioma: a prospective study. J Clin Neurosci; 2010 Jun;17(6):810-1
Hazardous Substances Data Bank. ETHANOL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute hemodynamic instability during alcohol ablation of symptomatic vertebral hemangioma: a prospective study.
  • Symptomatic vertebral hemangiomas (SVH) are difficult to treat and many therapeutic options, including surgery, radiotherapy, arterial embolization, and injection of methyl-methacrylate into hemagiomatous vertebrae have been reported.
  • Alcohol ablation of vertebral hemangiomas is an effective management option; however, a literature search did not reveal any reports of anesthetic complications or hemodynamic instability during and report a series of four males and seven females and report hemodynamic variations observed at the time of injection of absolute ethanol under general anesthetic, for the treatment of SVH.
  • All patients developed transient hypotension and bradycardia at the time of alcohol injection (8-10 mL of absolute alcohol).
  • [MeSH-major] Bradycardia / chemically induced. Central Nervous System Depressants / adverse effects. Ethanol / adverse effects. Hemodynamics / drug effects. Hypertension / chemically induced
  • [MeSH-minor] Adolescent. Adult. Child. Female. Hemangioma / drug therapy. Humans. Lumbar Vertebrae. Male. Prospective Studies. Spinal Neoplasms / drug therapy. Young Adult

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20400319.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Central Nervous System Depressants; 3K9958V90M / Ethanol
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9. Hsu W, Kosztowski TA, Zaidi HA, Dorsi M, Gokaslan ZL, Wolinsky JP: Multidisciplinary management of primary tumors of the vertebral column. Curr Treat Options Oncol; 2009 Apr;10(1-2):107-25
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OPINION STATEMENT: Primary spinal neoplasms are rare tumors that can lead to significant morbidity secondary to local bone destruction and invasion into adjacent neurological and vascular structures.
  • This review will discuss the most common primary bone tumors and focus on recent surgical, medical, and radiation treatment advances.
  • [MeSH-major] Spinal Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Cysts, Aneurysmal / therapy. Child. Chordoma / surgery. Combined Modality Therapy. Disease Management. Embolization, Therapeutic. Giant Cell Tumors / radiotherapy. Giant Cell Tumors / surgery. Giant Cell Tumors / therapy. Hemangioma / therapy. Hematopoietic Stem Cell Transplantation. Humans. Interdisciplinary Communication. Middle Aged. Neoplasms, Bone Tissue / drug therapy. Neoplasms, Bone Tissue / radiotherapy. Neoplasms, Bone Tissue / surgery. Neoplasms, Plasma Cell / drug therapy. Neoplasms, Plasma Cell / surgery. Young Adult

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  • (PMID = 19548089.001).
  • [ISSN] 1534-6277
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 164
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10. Petridis AK, Hempelmann RG, Hugo HH, Eichmann T, Mehdorn HM: Metastatic low-grade inflammatory myofibroblastic tumor (IMT) in the central nervous system of a 29-year-old male patient. Clin Neuropathol; 2004 Jul-Aug;23(4):158-66
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of myofibrosarcoma (IMT) of the brain and lung as well as the spinal cord is described.
  • Computer tomography identified a bleeding in the left frontal lobe.
  • In the further clinical history the patient developed a large spinal cord metastasis of the thoracic spine.
  • The current therapy of these tumors consists of complete tumor resection and further clinical controls.
  • There is no proven role of chemotherapy and radiation therapy.
  • [MeSH-major] Central Nervous System Neoplasms / secondary. Fibrosarcoma / secondary. Lung Neoplasms / pathology. Neoplasms, Muscle Tissue / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Hemangioma, Cavernous, Central Nervous System / pathology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Inflammatory myofibroblastic tumor.
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  • (PMID = 15328880.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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11. Dunn J: Percutaneous vertebroplasty in the management of a patient with malignant pain and associated osteolytic compression fractures. Curr Pain Headache Rep; 2002 Dec;6(6):436-43
Hazardous Substances Data Bank. MORPHINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Percutaneous vertebroplasty is a minimally invasive procedure that is effective in the treatment of pain resulting from pathologic compression fractures, osteolytic bone metastases from solid tumors, myeloma, vertebral hemangioma, and osteoporotic compression fractures.
  • Despite treatment with opiates, chemotherapy, radiation therapy, and the implantation of a morphine pump, her pain was not adequately treated until she underwent multilevel vertebroplasty.
  • [MeSH-major] Lumbar Vertebrae / surgery. Osteolysis / complications. Osteolysis / therapy. Pain / etiology. Pain / surgery. Spinal Fractures / complications. Spinal Fractures / therapy. Surgical Procedures, Operative / methods
  • [MeSH-minor] Adult. Anesthetics, Local / therapeutic use. Bupivacaine / therapeutic use. Chronic Disease. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Morphine / therapeutic use. Narcotics / therapeutic use. Osteoporosis / complications. Osteoporosis / therapy

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  • (PMID = 12413402.001).
  • [ISSN] 1531-3433
  • [Journal-full-title] Current pain and headache reports
  • [ISO-abbreviation] Curr Pain Headache Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Local; 0 / Narcotics; 76I7G6D29C / Morphine; Y8335394RO / Bupivacaine
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12. Turowski B, Zanella FE: Interventional neuroradiology of the head and neck. Neuroimaging Clin N Am; 2003 Aug;13(3):619-45
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Vascular interventions are important and helpful for treatment of various pathologies of the head and neck.
  • Interventional neuroradiology of the head and neck includes image-guided biopsies, vessel occlusion, and local chemotherapy.
  • Knowledge of anatomy, functional relationships between intra- and extracranial vessels, and pathology are the basis for therapeutic success.
  • Neuroradiologic imaging, especially CT and MR imaging, and appropriate analysis of angiographic findings help ensure indication for treatment and plan an intervention.
  • Indications for image-guided biopsies are preverterbal fluid-collections, spinal and paraspinal inflammations and abscesses, deep cervical malignancies, vertebral body, and skull base tumors.
  • Special care should be taken to preserve critical structures in this region, including spinal nerve roots, cervical plexus, main peripheral nerves, and vessels.
  • Examples of these interventions are: a hemangioma of the hard palate, a juvenile angiofibroma, a hemangiopericytoma, a malignant meningioma, a malignant fibrous histiocytoma, and a glomus tumor.
  • Effective treatment of vascular malformations, such as AV fistulas or angiomas, needs exact occlusion of the fistula or the angiomatous nidus, which is demonstrated in the case of an AV angioma of the base of the tongue.
  • Chemotherapy with local intra-arterial cisplatin combined with intravenous administration of sodium thiosulfate as antidote is indicated as an adjuvant modality in a multimodal regimen of oropharyngeal squamous cell carcinoma or as palliative treatment of recurrent and otherwise untreatable malignant tumors of the head and neck.
  • Palliative treatment of a bleeding oropharyngeal cancer is another example of interventional treatment.
  • Selective treatment, either occluding or pharmacologic, may be preoperative, palliative, or curative.
  • The objective is reduction of surgical risk, improvement of quality of life, or curative therapy of a lesion.
  • Thus, the interventional treatment should not be associated with morbidity or mortality.
  • The benefits, risks, and expected damages of neuroradiologic interventions must be balanced during the informed consent procedure with the patient.
  • [MeSH-major] Head and Neck Neoplasms / radiography. Head and Neck Neoplasms / therapy. Neuroradiography. Radiology, Interventional

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  • (PMID = 14631695.001).
  • [ISSN] 1052-5149
  • [Journal-full-title] Neuroimaging clinics of North America
  • [ISO-abbreviation] Neuroimaging Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 40
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