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1. Kuo SC, Chao Y, Luo JC, Lee KC, Wu CW, Li AF, Lee RC, Li CP: Primary small cell carcinoma of the stomach successfully treated with cisplatin and etoposide. J Chin Med Assoc; 2009 Nov;72(11):598-602
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary small cell carcinoma of the stomach successfully treated with cisplatin and etoposide.
  • We report a 44-year-old man with primary gastric small cell carcinoma who showed a remarkable response to chemotherapy specific for pulmonary small cell carcinoma.
  • Computed tomography revealed a mass over the lesser curvature of the stomach and some enlarged regional lymph nodes.
  • Pathology revealed gastric mucosa infiltrated by small-sized tumor cells with scanty cytoplasm and hyperchromatic nuclei.
  • Primary gastric small cell carcinoma was diagnosed.
  • Follow-up computed tomography showed tumor recurrence with multiple enlarged lymph nodes in the aortocaval region and hepatic hilum.
  • The patient received palliative chemotherapy consisting of cisplatin 80 mg/m(2) on day 1 and etoposide 80 mg/m(2) on days 1-3 every 28 days, and had partial response to the chemotherapy, with a progression-free survival of 10 months.
  • Chemotherapy with cisplatin and etoposide used for small cell carcinoma of the lung is a good treatment for gastric small cell carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19948438.001).
  • [ISSN] 1728-7731
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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2. Nathan JD, Gingalewski C, Salem RR: Intra-abdominal desmoplastic small round cell tumor. Yale J Biol Med; 2001 Jan-Feb;74(1):13-20
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  • [Title] Intra-abdominal desmoplastic small round cell tumor.
  • BACKGROUND: Intra-abdominal desmoplastic small round cell tumor is a rare malignancy with a predilection for young males.
  • Unique histological and immunocytochemical features distinguish the tumor from other members of the family of small round cell tumors of infancy and childhood.
  • The aggressive nature of tumor spread, relative insensitivity to chemotherapy, and generally incomplete resectability result in a very poor prognosis.
  • The authors report a case of a 39-year-old man with diffuse abdominal and pelvic involvement of intra-abdominal desmoplastic small round cell tumor treated with aggressive chemotherapy and surgery.
  • METHODS: Computed tomography (CT)-guided biopsy of an omental mass was performed.
  • On the basis of these unique histological and immunohistochemical characteristics, the diagnosis of desmoplastic small round cell tumor was made.
  • The patient was treated with aggressive neoadjuvant chemotherapy consisting of a high-dose alkylator -based combination regimen, followed by surgery.
  • RESULTS: The patient had a 10 to 15 percent regression in tumor mass in response to chemotherapy.
  • Laparotomy revealed two large omental masses, another large mass adherent to the left colon and pelvic sidewall, and diaphragmatic, peritoneal and mesenteric studding with small nodules.
  • CONCLUSIONS: Intra-abdominal desmoplastic small round cell tumor remains an aggressive malignancy with an extremely poor prognosis.
  • Although some response to chemotherapy may be possible, complete resection is rare, and surgical efforts are generally palliative.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Stomach Neoplasms / pathology

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  • (PMID = 11249235.001).
  • [ISSN] 0044-0086
  • [Journal-full-title] The Yale journal of biology and medicine
  • [ISO-abbreviation] Yale J Biol Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2588677
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3. Koch B, Tannapfel A, Vieth M, Grün R: [Gastric metastasis from small cell lung cancer]. Pneumologie; 2009 Oct;63(10):585-7
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  • [Title] [Gastric metastasis from small cell lung cancer].
  • Small cell carcinomas are most frequently localised within the lung, however, they also may be detected at extrapulmonary sites such as the gastrointestinal tract and the genitourinary tract.
  • The confirmation of a small cell carcinoma outside of the lung may not necessarily indicate the presence of a metastasis, however, it also may represent the primary tumor itself.
  • We present the case of a patient with a small cell carcinoma of the lung with metastases to the stomach.
  • A regression of the primary lung tumor and the disappearance of the gastric metastases could be achieved by chemotherapeutic treatment with carboplatin, etoposide, and vincristine.
  • However, death due to pneumonia occurred 3 months after initial diagnosis.
  • This case illustrates that in rare cases a metastasis from small cell lung cancer may occur in the intestinal tract even without leading to distinctive symptoms.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Lung Neoplasms / pathology. Stomach Neoplasms / drug therapy. Stomach Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Etoposide / administration & dosage. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Metastasis. Pneumonia / chemically induced. Vincristine / administration & dosage

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 19708008.001).
  • [ISSN] 1438-8790
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
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4. Wu Z, Ma JY, Yang JJ, Zhao YF, Zhang SF: Primary small cell carcinoma of esophagus: report of 9 cases and review of literature. World J Gastroenterol; 2004 Dec 15;10(24):3680-2
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  • [Title] Primary small cell carcinoma of esophagus: report of 9 cases and review of literature.
  • AIM: To analyze the clinical manifestations, pathological features and treatment of primary small cell carcinoma (SCC) of the esophagus and to review the literature on this entity.
  • METHODS: The records of 9 patients with primary esophageal small cell carcinoma were examined and the demographic data, presenting symptoms, methods of tumor diagnosis, and types of treatment given, response to treatment, pathologic findings, and clinical outcome were reviewed.
  • They underwent radical resection, regional lymph node clearance and esophageal-stomach anastomosis in thorax or at neck.
  • Three of the nine resected specimens showed foci of squamous cell carcinoma in situ.
  • They received adjuvant systemic chemotherapy and local radiation therapy after discharge.
  • During follow-up, three patients developed multiple liver, brain, lung and bone metastases and died between 5 and 18 mo after the diagnosis.
  • Three patients developed widespread metastasis disease and died between 18 and 37 mo after the diagnosis.
  • CONCLUSION: Primary small cell carcinoma of the esophagus is a rare but very malignant tumor.
  • Radical resection combined with chemotherapy and radiotherapy is helpful in limited stage cases.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Esophageal Neoplasms / pathology

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  • (PMID = 15534932.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 18
  • [Other-IDs] NLM/ PMC4612018
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5. Hamano R, Hirao T, Tokuoka M, Masuzawa T, Shibata K, Kobayashi T: [A case report of gastric small cell carcinoma with long survival time by adjuvant chemotherapy--reports of chemotherapy regimens for gastric small cell carcinoma]. Gan To Kagaku Ryoho; 2007 Apr;34(4):609-13
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  • [Title] [A case report of gastric small cell carcinoma with long survival time by adjuvant chemotherapy--reports of chemotherapy regimens for gastric small cell carcinoma].
  • Gastric small cell carcinomas are rather rare.
  • The incidence of small cell carcinomas of all histological types of gastric tumors is about 0.1%.
  • Small cell carcinoma is a very aggressive cancer with a poor prognosis,and there is no effective chemotherapy to date.
  • We experienced a case of small cell carcinoma of the stomach with relatively long survival from combination chemotherapy.
  • We used combination chemotherapy with tegafur/gimeracil/oteracil potassium+cisplatin and irinotecan hydrochloride+cisplatin, and he has obtained a long survival time.
  • We should gather more chemotherapy cases and establish some effective regimens for small cell carcinoma of the stomach.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Aged. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Drug Administration Routes. Drug Combinations. Gastrectomy. Humans. Lymph Node Excision. Male. Oxonic Acid / administration & dosage. Survivors. Tegafur / administration & dosage

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  • (PMID = 17431350.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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6. Shimada M, Iwase H, Iyo T, Nakarai K, Kaida S, Indo T, Doi R, Okeya M, Goto H: [A case of complete response in a primary lesion treated by combined chemotherapy of TS-1 and CDDP for small cell carcinoma of the stomach with liver metastasis]. Gan To Kagaku Ryoho; 2004 Apr;31(4):593-6
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  • [Title] [A case of complete response in a primary lesion treated by combined chemotherapy of TS-1 and CDDP for small cell carcinoma of the stomach with liver metastasis].
  • A 75-year-old male patient with small cell carcinoma of the stomach and liver metastasis was treated by combined chemotherapy of TS-1 and CDDP.
  • The TS-1/CDDP chemotherapy regimen is considered effective for small cell carcinoma of the stomach with liver metastasis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Carcinoma, Small Cell / secondary. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Aged. Cisplatin / administration & dosage. Drug Administration Schedule. Drug Combinations. Humans. Male. Oxonic Acid / administration & dosage. Pyridines / administration & dosage. Remission Induction. Tegafur / administration & dosage

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  • (PMID = 15114706.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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7. Hasegawa S, Yamamoto Y, Ishiwa N, Yoshikawa T, Morinaga S, Noguchi Y, Matsumoto A: [A case of small cell carcinoma of the stomach]. Gan To Kagaku Ryoho; 2003 Jul;30(7):999-1002
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  • [Title] [A case of small cell carcinoma of the stomach].
  • We report a case of small cell carcinoma of the stomach in a 60-year-old man.
  • The patient was found to have a gastric tumor by routine upper gastrointestinal endoscopy for chronic gastrititis, and was admitted to the hospital.
  • The patient underwent a curative distal gastrectomy with D2 lymph node dissection following a diagnosis of early gastric cancer at the posterior wall of the antrum, in June 2001.
  • The final pathological diagnosis was small cell carcinoma of the stomach with severe lymphatic and vascular invasion (INF alpha, sm, ly3 v2, n1 (+)).
  • In a review of 47 cases seen in the Japanese literature, only 5 patients had early gastric cancer.
  • Four of the 5 patients with early gastric cancer (80.0%) had lymph node metastases.
  • The prognosis was reported to be extremely poor because small cell carcinoma frequently metastasizes to lymph nodes and/or the liver even in an early stage.
  • The chemotherapy selected by many hospitals is mainly CDDP, but the use of chemotherapeutic drugs varied from hospital to hospital and no effective chemotherapy for the disease has been established as yet.
  • [MeSH-major] Carcinoma, Small Cell. Stomach Neoplasms
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Combined Modality Therapy. Gastrectomy. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged

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  • (PMID = 12894718.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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8. Rossi G, Marchioni A, Romagnani E, Bertolini F, Longo L, Cavazza A, Barbieri F: Primary lung cancer presenting with gastrointestinal tract involvement: clinicopathologic and immunohistochemical features in a series of 18 consecutive cases. J Thorac Oncol; 2007 Feb;2(2):115-20
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  • The clinicopathologic characteristics of the largest series of lung carcinomas initially presenting with GI involvement were described, focusing on differential diagnosis and therapeutic options.
  • The small bowel was the most common GI involved site (12 cases), followed by the stomach (four) and large intestine (two).
  • Fourteen patients died shortly from disease (mean follow-up, 3 months); two are still alive with multiple metastases, and two patients with the GI tract as the unique site of metastasis underwent pulmonary lobectomy and chemotherapy and are alive without evidence of disease.
  • At morphology, there were 10 large cell undifferentiated carcinomas and eight adenocarcinomas.
  • CONCLUSION: Lung cancer presenting as GI-tract metastasis is probably more frequent than expected, and pathologists should always keep in mind this possibility when dealing with undifferentiated GI carcinoma.
  • Although GI metastasis from lung cancer is associated with dismal outcomes, pulmonary resection coupled with chemotherapy might represent a therapeutic option in selected patients with a solitary GI-tract metastasis.
  • [MeSH-major] Gastrointestinal Neoplasms / diagnosis. Lung Neoplasms / pathology

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  • (PMID = 17410025.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Inagaki H, Yokoyama T, Kikuchi M, Yokoyama Y: [A case of gastric small cell carcinoma with metastatic liver tumors responding to adjuvant chemotherapy]. Gan To Kagaku Ryoho; 2010 Oct;37(10):1953-6
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  • [Title] [A case of gastric small cell carcinoma with metastatic liver tumors responding to adjuvant chemotherapy].
  • A 71-year-old man, whose chief complaint was a faecal occult blood, had gastrointestinal endoscopy and gastric cancer was diagnosed.
  • We performed total gastrectomy with D2 lymph dissection, partial hepatic resections and microwave coagulation therapy.
  • Small cell carcinoma of the stomach was diagnosed by histopathological findings.
  • We used combination chemotherapy consisting of carboplatin, epirubicin, etoposide and 5-FU was performed.
  • We conclude that adjuvant chemotherapy was effective for small cell carcinoma of the stomach, which was to be considered to have a poor prognosis.
  • [MeSH-major] Carcinoma, Small Cell / drug therapy. Liver Neoplasms / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 20948263.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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10. Nakamura Y, Otani S, Otaka M, Shimada T, Takahashi S, Saito M, Takahashi T, Komatsu M, Suzuki T, Okubo S, Hayashi M, Sasano H: Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy. Int J Clin Oncol; 2005 Oct;10(5):348-52
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  • [Title] Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy.
  • We report a patient with gastric small cell carcinoma (SCC) who showed a marked response to neoadjuvant chemotherapy.
  • Subsequent examination revealed the presence of advanced gastric carcinoma in the lesser curvature of the lower body of the stomach, with multiple abdominal lymph node metastases.
  • The patient received neoadjuvant chemotherapy consisting of carboplatin (400 mg/m2, for 1 day), epirubicin (27 mg/m2, for 1 day), etoposide (70 mg/m2, for 3 days), and 5-fluorouracil (330 mg/m2, for 11 days).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Neoadjuvant Therapy. Stomach Neoplasms / drug therapy

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  • (PMID = 16247663.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Kato T, Sato K, Tamahashi N, Yano H, Masuoka HO: [A case of small cell carcinoma of the stomach]. Gan To Kagaku Ryoho; 2005 Oct;32(10):1473-5
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  • [Title] [A case of small cell carcinoma of the stomach].
  • We report a rare case of small cell carcinoma of the stomach with metastasis to the liver and invasion of the pancreas, which was associated with acute peritonitis due to perforation of the stomach.
  • CPT-11/CDDP chemotherapy achieved a partial response.
  • A 60-year-old man suddenly developed abdominal pain and visited the emergency room.
  • An emergency operation was performed with an omental patch for closing the perforated hole in the stomach.
  • Excisional biopsy was performed to the small liver nodule.
  • Histological findings showed that the liver nodule was metastasis from small cell carcinoma.
  • There was no finding from the thoracic CT scan, but gastroscopy revealed a giant tumor, which was diagnosed as small cell carcinoma in histology.
  • Therefore, we diagnosed small cell carcinoma of the stomach with liver metastasis and invasion of the pancreas.
  • After operation, one course of FP chemotherapy was performed, but the liver metastasis increased in size.
  • Then we changed to CPT-11/CDDP chemotherapy as second-line therapy, and achieved partial remission (PR) of both the liver metastasis and gastric tumor.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Gastrectomy. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Invasiveness. Pancreatic Neoplasms / pathology. Rupture, Spontaneous. Stomach Rupture / etiology

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  • (PMID = 16227752.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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12. Wada Y, Yamamoto T, Kita Y, Fukunishi S, Ashida K: [An autopsy case of encephalopathy associated with small cell carcinoma of the stomach with nonconvulsive status epilepticus resembling Creutzfeldt-Jakob disease]. No To Shinkei; 2003 May;55(5):423-8
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  • [Title] [An autopsy case of encephalopathy associated with small cell carcinoma of the stomach with nonconvulsive status epilepticus resembling Creutzfeldt-Jakob disease].
  • A 64-year-old man developed progressive dementia and altered consciousness with myoclonus over 2 months.
  • Since his consciousness level fluctuated and the PSD were spiky, we came to a diagnosis of nonconvulsive status epilepticus (NCSE).
  • Now CT scans of the abdomen showed enlarged periaortic lymph node and endoscopic ultrasonography disclosed a submucosal tumor of the stomach.
  • Chemotherapy didn't work well for the tumor and the patient underwent a downhill course, although his mental and neurological manifestation were mostly unremarkable.
  • Autopsy confirmed small cell carcinoma originating in the stomach and metastases in the liver and lungs.
  • [MeSH-major] Brain Diseases / pathology. Carcinoma, Small Cell / complications. Creutzfeldt-Jakob Syndrome / diagnosis. Status Epilepticus / diagnosis. Stomach Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging. Electroencephalography. Humans. Male


13. Koide N, Suzuki A, Saito H, Sato T, Murakami M, Ota H, Miyagawa S: Gastric small cell carcinoma successfully treated by surgery and postoperative chemotherapy consisting of cisplatin and S-1: report of a case. Surg Today; 2007;37(11):989-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric small cell carcinoma successfully treated by surgery and postoperative chemotherapy consisting of cisplatin and S-1: report of a case.
  • We herein report a case of gastric small cell carcinoma (GSCC), which was successfully treated by surgery and postoperative chemotherapy consisting of cisplatin (CDDP) and the fluoropyrimidine S-1.
  • The patient was a 63-year-old man in whom a gastric tumor had been endoscopically detected.
  • The type 1 tumor was located in the gastric body.
  • An abdominal computed tomogram showed many metastasized nodes around the stomach.
  • Furthermore, washing peritoneal cytology histologically revealed the presence of carcinoma cells.
  • We reviewed 52 Japanese patients with GSCC/endocrine cell carcinoma (EC) reported between 2001 and 2005 with reference to chemotherapy.
  • Chemotherapy using S-1 was performed for 11 of the 52 patients.
  • Four of the 11 patients, including the present case, who were treated with S-1 survived for over 2 years after surgery, although the GSCC/EC of the four patients were staged as III or IV.
  • Therefore, chemotherapy consisting of CDDP and S-1 may provide a survival benefit for patients with GSCC/EC.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Small Cell / drug therapy. Cisplatin / therapeutic use. Gastrectomy / methods. Oxonic Acid / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use
  • [MeSH-minor] Antimetabolites, Antineoplastic / therapeutic use. Diagnosis, Differential. Drug Combinations. Drug Therapy, Combination. Endoscopy, Gastrointestinal. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Tomography, X-Ray Computed

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  • [Cites] Hepatogastroenterology. 2004 Sep-Oct;51(59):1567-70 [15362803.001]
  • [Cites] Dig Dis Sci. 1990 Apr;35(4):513-8 [2156662.001]
  • [Cites] Gastric Cancer. 2004;7(2):122-7 [15224200.001]
  • [Cites] J Gastroenterol Hepatol. 2003 Jun;18(6):743-7 [12753162.001]
  • [Cites] Fukuoka Igaku Zasshi. 1976 Feb;67(2):65-73 [177344.001]
  • [Cites] Am J Clin Oncol. 1998 Oct;21(5):458-61 [9781599.001]
  • [Cites] Am J Gastroenterol. 1991 Sep;86(9):1167-75 [1715667.001]
  • [Cites] Gastric Cancer. 2005;8(2):111-6 [15864718.001]
  • [Cites] Anticancer Drugs. 1996 Jul;7(5):548-57 [8862723.001]
  • [Cites] Oncology. 1999 Oct;57(3):202-10 [10545788.001]
  • [Cites] Gastric Cancer. 1998 Dec;1(1):10-24 [11957040.001]
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  • [Cites] Arch Pathol Lab Med. 1998 Nov;122(11):1010-7 [9822131.001]
  • [Cites] Br J Cancer. 2003 Dec 15;89(12):2207-12 [14676796.001]
  • [Cites] Surg Today. 2003;33(4):294-8 [12707827.001]
  • (PMID = 17952533.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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14. Saeki H, Anegawa G, Masuda T, Ohta R, Honda M, Kai T, Kaneko S, Anai H, Nakamura Y, Yokoyama S: [A case of inoperable gastric small cell carcinoma effectively treated by chemotherapy and radiotherapy]. Gan To Kagaku Ryoho; 2006 Jul;33(7):977-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of inoperable gastric small cell carcinoma effectively treated by chemotherapy and radiotherapy].
  • We herein report a case of advanced gastric small cell carcinoma treated by chemotherapy and radiotherapy.
  • He was diagnosed to have an inoperable gastric small cell carcinoma with severe lymph node metastases and left adrenal gland metastasis.
  • Chemotherapy with TS-1/paclitaxel, cisplatin/irinotecan and cisplatin/etoposide was sequentially performed.
  • Eighteen months after the initial therapy, he had dysarthrosis and multiple brain metastases were found.
  • We conclude that chemotherapy and radiotherapy are effective for primary and metastatic lesions of gastric small cell carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Carcinoma, Small Cell / radiotherapy. Stomach Neoplasms / drug therapy. Stomach Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Brain Neoplasms / radiotherapy. Brain Neoplasms / secondary. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage. Combined Modality Therapy. Cranial Irradiation. Drug Administration Schedule. Drug Combinations. Etoposide / administration & dosage. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Oxonic Acid / administration & dosage. Paclitaxel / administration & dosage. Tegafur / administration & dosage

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  • (PMID = 16835491.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 6PLQ3CP4P3 / Etoposide; 7673326042 / irinotecan; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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15. Hosokawa A, Shimada Y, Shirao K, Matsumura Y, Yamada Y, Muro K, Hamaguchi T, Gotoh M, Shimoda T: Long-term survivor of gastric small cell carcinoma. Hepatogastroenterology; 2004 Sep-Oct;51(59):1567-70
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  • [Title] Long-term survivor of gastric small cell carcinoma.
  • We describe the long-term survival of a patient following the diagnosis of primary gastric small cell carcinoma.
  • In January 2000, a 73-year-old male was found to have advanced gastric small cell carcinoma directly invading his liver.
  • He received combination chemotherapy with cisplatin and irinotecan as first-line chemotherapy, then cisplatin and etoposide as second-line chemotherapy.
  • He had a complete response after four cycles of second-line chemotherapy.
  • In March 2001, the tumor recurred in the stomach and the patient underwent a total gastrectomy.
  • He has survived free of disease for more than 2 years after the first diagnosis.
  • [MeSH-major] Carcinoma, Small Cell / mortality. Stomach Neoplasms / mortality. Survivors
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Cervical Intraepithelial Neoplasia. Combined Modality Therapy. Gastrectomy. Gastric Mucosa / pathology. Gastroscopy. Humans. Male. Neoadjuvant Therapy. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Tomography, X-Ray Computed

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  • (PMID = 15362803.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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16. Kusayanagi S, Konishi K, Miyasaka N, Sasaki K, Kurahashi T, Kaneko K, Akita Y, Yoshikawa N, Kusano M, Yamochi T, Kushima M, Mitamura K: Primary small cell carcinoma of the stomach. J Gastroenterol Hepatol; 2003 Jun;18(6):743-7
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  • [Title] Primary small cell carcinoma of the stomach.
  • We report on an 80-year-old man with primary gastric small cell carcinoma (SmCC).
  • An upper gastrointestinal examination revealed an irregularly ulcerated tumor, 60 mm in diameter, on the lesser curvature of the stomach body extending to the cardia.
  • Therefore, primary gastric SmCC was diagnosed preoperatively.
  • To date, only 38 cases of primary gastric SmCC, including our case, have been reported.
  • In the reported cases of gastric SmCC, the endoscopic findings frequently indicated a submucosal tumor.
  • Gastric SmCC is clinically aggressive and has an extremely poor prognosis, even when discovered at an early stage.
  • Most patients with gastric SmCC die within 1 year of diagnosis.
  • Although a standard treatment for gastric SmCC has not been established, intensive chemotherapy should be considered to promote long-term survival.
  • We believe that careful examination, including immunohistochemical investigation, is necessary for determining the therapeutic strategy whenever gastric SmCC is suspected during endoscopy.
  • [MeSH-major] Carcinoma, Small Cell / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor. Biopsy. Carcinoembryonic Antigen. Chromogranin A. Chromogranins. Endoscopy, Gastrointestinal. Gastric Mucosa / pathology. Humans. Immunohistochemistry. Male. Phosphopyruvate Hydratase

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  • (PMID = 12753162.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen; 0 / Chromogranin A; 0 / Chromogranins; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Number-of-references] 27
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17. Cioppa T, Marrelli D, Neri A, Caruso S, Pedrazzani C, Malagnino V, Pinto E, Roviello F: A case of small-cell gastric carcinoma with an adenocarcinoma component and hepatic metastases: treatment with systemic and intra-hepatic chemotherapy. Eur J Cancer Care (Engl); 2007 Sep;16(5):453-7
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  • [Title] A case of small-cell gastric carcinoma with an adenocarcinoma component and hepatic metastases: treatment with systemic and intra-hepatic chemotherapy.
  • Primary small-cell carcinoma (SmCC) of the stomach is a rare neoplasm with a poor prognosis and unclear histogenesis: to date, only 50 cases, including ours, have been reported in the literature.
  • In the World Health Organization gastrointestinal tumours' classification, SmCC of the stomach has been recognized as an 'independent entity affecting the stomach'.
  • In this paper, the authors present a clinical case and the surgical treatment of an adult with a SmCC of the stomach associated with gastric adenocarcinoma.
  • A palliative resection, subtotal gastrectomy, was performed, followed by systemic and intra-hepatic chemotherapy: computed tomography scan demonstrated a marked response, but the patient died 15 months after the operation.
  • A review of the literature showed that the diagnosis of gastric SmCC is based on immunohistochemical findings.
  • Our experience confirmed the high aggressiveness of this neoplasm, which is generally diagnosed in advanced stage and is unresponsive to chemotherapy, but the combined use of systemic and intra-hepatic chemotherapy shows an acceptable result in a palliative care perspective.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / secondary. Kidney Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Fatal Outcome. Gastrectomy. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17760934.001).
  • [ISSN] 0961-5423
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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18. Sun YL, Liu YW, Zhong DR, Gao WS: [Gastric small cell carcinoma: 6 cases report and review of literature]. Zhonghua Wai Ke Za Zhi; 2008 May 15;46(10):756-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gastric small cell carcinoma: 6 cases report and review of literature].
  • OBJECTIVE: To report the management experiences of of gastric small cell carcinoma.
  • METHODS: The clinicopathological data of 6 cases of gastric small cell carcinoma treated from 1997 to 2007 were retrospectively reviewed.
  • All the patients received surgery and 4 of them received postoperative adjuvant chemotherapy.
  • Tumor located in the fundus in 97 cases, 55 in gastric body,54 in gastric antrum.
  • In gross, 137 cases were classified as ulcerative type, 47 were protruded type.
  • CONCLUSIONS: It is difficult to make a definite diagnosis before or during the operation for gastric small cell carcinoma.
  • The radical operation could be done according to other gastric cancer and the lymph node dissection could be simplified.
  • Postoperative chemotherapy with the same scheme as lung small cell carcinoma may help improving the outcome.
  • [MeSH-major] Carcinoma, Small Cell / therapy. Stomach Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Follow-Up Studies. Gastrectomy. Humans. Lymph Node Excision. Male. Middle Aged. Prognosis. Retrospective Studies

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  • (PMID = 18953931.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Namikawa T, Kobayashi M, Okabayashi T, Ozaki S, Nakamura S, Yamashita K, Ueta H, Miyazaki J, Tamura S, Ohtsuki Y, Araki K: Primary gastric small cell carcinoma: report of a case and review of the literature. Med Mol Morphol; 2005 Dec;38(4):256-61
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  • [Title] Primary gastric small cell carcinoma: report of a case and review of the literature.
  • A 52-year-old man suffering from a pure-type primary gastric small cell carcinoma was treated with surgery and combination chemotherapy.
  • The small cell carcinoma, approximately 6.5 cm in diameter, was situated in the posterior wall of the antrum and there were no distant metastases.
  • Histological examination revealed a solid pattern of proliferation of small cells with hyperchromatic, round nuclei and scant cytoplasm.
  • Accumulations of electron-dense core granules in the small neoplastic cells were seen by electron microscopy.
  • Following surgery, the patient was treated with adjuvant chemotherapy consisting of cisplatin and etoposide.
  • We review 107 published cases of primary gastric small cell carcinoma, an extremely rare disease first reported in 1976.
  • Small cell carcinoma is an aggressive, malignant tumor.
  • Intensive chemotherapy is essential for patient survival even when curative surgical resection is carried out.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Stomach Neoplasms / pathology

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  • [Cites] Dig Dis Sci. 1990 Apr;35(4):513-8 [2156662.001]
  • [Cites] Am J Gastroenterol. 1988 Oct;83(10):1176-9 [2844080.001]
  • [Cites] Jpn J Clin Oncol. 1997 Apr;27(2):95-100 [9152798.001]
  • [Cites] J Gastroenterol Hepatol. 2003 Jun;18(6):743-7 [12753162.001]
  • [Cites] Acta Oncol. 1997;36(1):78-80 [9090972.001]
  • [Cites] Fukuoka Igaku Zasshi. 1976 Feb;67(2):65-73 [177344.001]
  • [Cites] Int J Clin Oncol. 2002 Apr;7(2):128-32 [12018111.001]
  • [Cites] Hepatogastroenterology. 1997 Jan-Feb;44(13):156-60 [9058136.001]
  • [Cites] Am J Gastroenterol. 1991 Sep;86(9):1167-75 [1715667.001]
  • [Cites] Gan To Kagaku Ryoho. 1999 Jan;26(1):149-52 [9987513.001]
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  • [Cites] Cancer. 1985 Dec 15;56(12 ):2771-8 [2996747.001]
  • (PMID = 16378235.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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20. Warmerdam FA, Blaauwgeers JL, de Valk B, Roozendaal KJ: [A gastric signet ring cell carcinoma as the first expression of a breast carcinoma]. Ned Tijdschr Geneeskd; 2003 May 17;147(20):980-4
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  • [Title] [A gastric signet ring cell carcinoma as the first expression of a breast carcinoma].
  • Further examination showed linitis plastica due to a signet ring cell carcinoma in the stomach, multiple bone metastases, and an occult, small breast tumour.
  • Immunohistochemical comparison of the tumours strongly suggested that all cases involved a metastasised breast carcinoma.
  • At check-up after one year of tamoxifen treatment, the complaints had disappeared and the activity of the tumour marker had dropped.
  • Gastric metastases from breast carcinoma are rare.
  • Nevertheless, this possibility should be kept in mind in women presenting with malignancies of the stomach and mastopathy.
  • Hormonal treatment and chemotherapy may result in reasonable palliation.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Signet Ring Cell / diagnosis. Stomach Neoplasms / secondary
  • [MeSH-minor] Aged. Antineoplastic Agents, Hormonal / therapeutic use. Bone Neoplasms / diagnosis. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Diagnosis, Differential. Female. Humans. Tamoxifen / therapeutic use

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  • (PMID = 12784534.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen
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21. Brega-Massone PP, Conti B, Lequaglie C, Ferro F, Cataldo I: [The role of surgical therapy for esophageal microcytoma. Experience of there clinical cases and results analysis]. Minerva Chir; 2003 Aug;58(4):629-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The role of surgical therapy for esophageal microcytoma. Experience of there clinical cases and results analysis].
  • [Transliterated title] Il ruolo della terapia chirurgica nel microcitoma dell'esofago. Esperienza di tre casi clinici ed analisi dei risultati.
  • Small cell carcinoma of the esophagus is a rare tumor.
  • It was described for the first time in 1952 by McKeown and 200 cases have been reported till now.
  • Because of its similarity with small cell carcinoma of the lung, the treatment of this tumor is controversial.
  • In our Institute we treated three patients with small cell carcinoma of the esophagus.
  • The stage I and II patients received operation as single treatment.
  • The third patient, classified at stage III, underwent postoperative chemotherapy but local and distant recurrence was observed 11 months after surgical resection.
  • He was submitted to a second choice chemotherapy, but he died 24 months after the operation.
  • Our experience seems to demonstrate that an early diagnosis and oncological radical resection, may be helpful in the long-term prognosis even in presence of a very aggressive neoplasm.
  • [MeSH-major] Carcinoma, Small Cell / surgery. Esophageal Neoplasms / surgery. Esophagoplasty / methods. Vinblastine / analogs & derivatives
  • [MeSH-minor] Aged. Anastomosis, Surgical / methods. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Chemotherapy, Adjuvant. Combined Modality Therapy. Esophagectomy / methods. Esophagoscopy / methods. Etoposide / administration & dosage. Fatal Outcome. Female. Humans. Laparotomy / methods. Lymph Node Excision. Male. Middle Aged. Mitomycin / administration & dosage. Remission Induction. Stomach / surgery. Thoracotomy / methods

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  • (PMID = 14603180.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; Q6C979R91Y / vinorelbine
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22. Satoh M, Wakabayashi O, Araya Y, Jinushi E, Yoshida F: [Autopsy case of von Recklinghausen's disease associated with lung cancer, gastrointestinal stromal tumor of the stomach, and duodenal carcinoid tumor]. Nihon Kokyuki Gakkai Zasshi; 2009 Sep;47(9):798-804
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  • [Title] [Autopsy case of von Recklinghausen's disease associated with lung cancer, gastrointestinal stromal tumor of the stomach, and duodenal carcinoid tumor].
  • The tumor was diagnosed as a non-small-cell lung cancer with direct invasion to the adjacent rib.
  • Although chemotherapy and radiotherapy resulted in decrease in tumor size, the tumor subsequently increased in size and the patient died 14 months after the first admission.
  • Autopsy revealed multiple emphysematous bullae, poorly differentiated adenosquamous cell carcinoma of the lung, gastrointestinal stromal tumor of the stomach, and duodenal carcinoid tumor.
  • It has also been suggested that the genetic abnormality responsible for von Recklinghausen's disease increases the risk for various types of malignancy.
  • [MeSH-major] Autopsy. Carcinoid Tumor / etiology. Carcinoma, Adenosquamous / etiology. Duodenal Neoplasms / etiology. Gastrointestinal Stromal Tumors / etiology. Lung Neoplasms / etiology. Neoplasms, Multiple Primary. Neurofibromatosis 1 / complications
  • [MeSH-minor] Fatal Outcome. Humans. Male. Middle Aged. Pulmonary Emphysema / complications. Pulmonary Emphysema / diagnosis. Pulmonary Emphysema / pathology. Risk Factors

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  • (PMID = 19827584.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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23. Spigel DR, Hainsworth JD, Greco FA: Neuroendocrine carcinoma of unknown primary site. Semin Oncol; 2009 Feb;36(1):52-9

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  • [Title] Neuroendocrine carcinoma of unknown primary site.
  • Neuroendocrine carcinomas of unknown primary site are uncommon, diverse tumors with variable clinical behavior, predicted by tumor grade or differentiation.
  • Most of these carcinomas probably arise from an occult/clinically undetectable primary site in one of several locations (bronchus, pancreas, stomach, colon, rectum and several other sites).
  • Patients with these tumors are a subset of unknown primary carcinoma with relatively favorable prognoses.
  • Targeted therapies may have a role in the treatment of low-grade tumors.
  • The high-grade or poorly differentiated carcinomas, including small cell and large cell neuroendocrine tumors, are rapidly growing and aggressive but responsive to platinum-based combination chemotherapy.
  • Poorly differentiated large cell neuroendocrine tumors, first reported in 1988, are usually not recognized by routine hematoxylin and eosin light microscopy but require immunohistochemical stains or electron microscopy for their diagnosis.
  • A review of cytotoxic chemotherapy for patients with high-grade neuroendocrine carcinomas, including a series of 99 patients, revealed an overall response rate of 70%, with a 20% complete response rate.
  • Tumor grade/differentiation currently is an important determinant of the management of these patients, and therapy in the future will be based on a more precise knowledge of the unique biology of these tumors.
  • [MeSH-major] Carcinoma, Neuroendocrine / pathology. Neoplasms, Unknown Primary / pathology

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  • (PMID = 19179188.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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24. Nguyen-tat M, Pohl J, Günter E, Manner H, Plum N, Pech O, Ell C: Severe paraneoplastic gastroparesis associated with anti-Hu antibodies preceding the manifestation of small-cell lung cancer. Z Gastroenterol; 2008 Mar;46(3):274-8
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  • [Title] Severe paraneoplastic gastroparesis associated with anti-Hu antibodies preceding the manifestation of small-cell lung cancer.
  • Clinicians must also consider rare causes of gastric motor dysfunction, such as collagen vascular disorders and paraneoplastic syndromes.
  • Endoscopy showed a dilated fluid-filled stomach without peristalsis but no obstruction.
  • High titres of anti-Hu antibodies were detected in patient's serum, supporting the diagnosis of severe paraneoplastic gastroparesis with chronic intestinal pseudo-obstruction.
  • Fine-needle aspiration of suspicious mediastinal lymph nodes guided by endoscopic ultrasound revealed lymphatic metastases of a small-cell lung carcinoma.
  • Jejunal tube feeding and chemotherapy with carboplatin and etoposide were initiated.
  • Paraneoplastic gastrointestinal dysmotility is rare, however, clinicians should consider this differential diagnosis in otherwise unexplained gastrointestinal motor dysfunction.
  • The pathophysiology of paraneoplastic gastroparesis, the diagnostic relevance of anti-Hu antibodies as well as therapeutic options are discussed.
  • [MeSH-major] Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / immunology. ELAV Proteins / immunology. Gastroparesis / diagnosis. Gastroparesis / immunology. Lung Neoplasms / diagnosis. Lung Neoplasms / immunology. Paraneoplastic Syndromes / diagnosis. Paraneoplastic Syndromes / immunology

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  • (PMID = 18322883.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / ELAV Proteins
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25. Douwes KE, Burgdorff T, Szeimies RM, Messmann H, Vogt T, Landthaler M: [Paraneoplastic Bazex acrokeratosis in adenocarcinoma of the stomach]. Dtsch Med Wochenschr; 2001 Feb 23;126(8):203-6
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  • [Title] [Paraneoplastic Bazex acrokeratosis in adenocarcinoma of the stomach].
  • [Transliterated title] Paraneoplastische Akrokeratose Bazex bei Adenokarzinom des Magens.
  • Alcohol abuse had been present 10 years ago, together with a gastric ulcer.
  • X-rays of the thorax and sinuses as well as a sonography of the stomach revealed, except for a fatty liver, no pathological findings.
  • Gastroscopy revealed a chronic active gastritis on the small curvature of the stomach.
  • Only a second gastroscopy and biopsy revealed an adenocarcinoma of the stomach.
  • DIAGNOSIS, THERAPY AND COURSE: According to the clinical presentation a paraneoplastic acrokeratosis (Bazex syndrome) was diagnosed.
  • The patient was given high-dose chemotherapy with subsequent stem-cell transplantation and gastrectomy.
  • The skin problems resolved after the first cycles of chemotherapy.
  • CONCLUSION: If clinically a paraneoplastic acrokeratosis is suspected extensive search for a malignancy has to be initiated, including a gastroscopy, because rarely, but as in the present case, a carcinoma of the stomach can be the underlying cause.
  • [MeSH-major] Adenocarcinoma / diagnosis. Keratoderma, Palmoplantar / diagnosis. Paraneoplastic Syndromes / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Gastrectomy. Gastroscopy. Humans. Male. Middle Aged

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  • (PMID = 11256024.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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26. Hornick JL, Jaffe ES, Fletcher CD: Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol; 2004 Sep;28(9):1133-44
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  • Only small numbers of bona fide examples exist in the world literature; cases arising primarily at extranodal sites are not well described and often seem to go unrecognized.
  • Seven tumors arose in soft tissue (6 lower limb; 1 upper limb), 5 in the gastrointestinal tract (1 involving both stomach and colon, 1 ileum, 2 rectum, 1 anus), 1 in the nasal cavity, and 1 in the lung.
  • Six patients were treated with postoperative radiation and 7 with chemotherapy (CHOP or ProMACE-MOPP).
  • Two tumors recurred locally, and 5 patients developed distant spread: 3 to lymph nodes, 1 to lung, and 1 to bone.
  • At the last follow-up, 2 patients have died of disseminated disease, 4 and 5 months following initial diagnosis.
  • Histiocytic sarcoma may arise primarily in soft tissue and shows reproducible histologic features, including abundant eosinophilic cytoplasm and a prominent inflammatory infiltrate.
  • Metastatic carcinoma, metastatic melanoma, and large cell non-Hodgkin lymphomas should be excluded by immunohistochemistry.

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  • (PMID = 15316312.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Mattioli S, D'Ovidio F, Tazzari P, Pilotti V, Daddi N, Bandini G, Piccioli M, Pileri S: Iliac crest biopsy versus rib segment resection for the detection of bone marrow isolated tumor cells from lung and esophageal cancer. Eur J Cardiothorac Surg; 2001 May;19(5):576-9
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  • [Title] Iliac crest biopsy versus rib segment resection for the detection of bone marrow isolated tumor cells from lung and esophageal cancer.
  • OBJECTIVE: The presence of isolated tumor cells in the bone marrow affects the prognosis of both esophageal cancer and non-small cell lung cancer (NSCLC).
  • Therefore, preoperative assessment of isolated tumor cells may be useful to plan multimodality treatment.
  • Rib segment resection at surgery provides adequate amounts of bone marrow for the detection of isolated tumor cells while bone marrow aspirate from the iliac crest does not.
  • The iliac crest biopsy according to the Jamshidi technique procures a core of tissue apt for histology and not simply for cytology.
  • The aim of this study was to compare the accuracy of iliac crest biopsy versus rib segment resection in the diagnosis of isolated tumor cells in order to obtain a useful preoperative approach.
  • None had chemotherapy prior to evaluation.
  • Positive cytokeratin neoplastic cells were searched by immunohistochemistry on tissue sections from the iliac crest biopsies and by flow cytometry on cell suspensions from the rib segments.
  • CONCLUSION: Our results suggest that, if the diagnosis of bone marrow isolated tumor cells has clinical relevance, the preoperative assessment should be performed by rib segment resection or methods other than iliac crest aspirate or biopsy.
  • [MeSH-major] Adenocarcinoma / pathology. Bone Marrow Neoplasms / secondary. Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / pathology. Ilium / pathology. Lung Neoplasms / pathology. Ribs / pathology
  • [MeSH-minor] Biopsy. Cardia. Humans. Immunohistochemistry. Neoplasm Staging / methods. Stomach Neoplasms / pathology


28. Kianmanesh R, O'toole D, Sauvanet A, Ruszniewski P, Belghiti J: [Surgical treatment of gastric, enteric, and pancreatic endocrine tumors Part 1. Treatment of primary endocrine tumors]. J Chir (Paris); 2005 May-Jun;142(3):132-49
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  • [Title] [Surgical treatment of gastric, enteric, and pancreatic endocrine tumors Part 1. Treatment of primary endocrine tumors].
  • [Transliterated title] Traitement chirurgical des tumeurs endocrines gastro-entéro-pancréatiques.
  • Endocrine tumors (ET) of the digestive tract (formerly called neuroendocrine tumors) are rare.
  • They are classified into two principal types: gastrointestinal ET's (formerly called carcinoid tumors) which are the most common, and pancreaticoduodenal ET's.
  • Poorly-differentiated ET's have a poor prognosis and are treated by chemotherapy.
  • Surgical excision is the only curative treatment of well-differentiated ET's.
  • The most common sites of gastrointestinal ET's ( carcinoids) are the appendix and the rectum; these are often small (<1 cm), benign, and discovered fortuitously at the time of appendectomy or colonoscopic removal.
  • Ileal ET's, even if small, are malignant, frequently multiple, and complicated in 30-50% of cases by bowel obstruction, mesenteric invasion, or bleeding.
  • They are usually malignant and of advanced stage at diagnosis presenting as a palpable or obstructing mass or as liver metastases.
  • Insulinoma and gastrinoma (cause of the Zollinger-Ellison syndrome) are the most common functional ET's. 80% are sporadic; in these cases, tumor size, location, and malignant potential determine the type of resection which may vary from a simple enucleation to a formal pancreatectomy.
  • In 10-20% of cases, pancreaticoduodenal ET presents in the setting of multiple endocrine neoplasia (NEM type I), an autosomal-dominant genetic disease with multifocal endocrine involvement of the pituitary, parathyroid, pancreas, and adrenal glands.
  • For insulinoma with NEM-I, enucleation of lesions in the pancreatic head plus a caudal pancreatectomy is the most appropriate procedure.
  • The lesions are frequently small, multiple, and widespread and recurrence is frequent after excision.
  • [MeSH-major] Carcinoid Tumor / surgery. Carcinoma, Islet Cell / surgery. Carcinoma, Neuroendocrine / surgery. Insulinoma / surgery. Intestinal Neoplasms / surgery. Multiple Endocrine Neoplasia Type 1 / surgery. Pancreatic Neoplasms / surgery. Stomach Neoplasms / surgery. Zollinger-Ellison Syndrome / surgery
  • [MeSH-minor] Adult. Gastrinoma / diagnosis. Gastrinoma / surgery. Glucagonoma / diagnosis. Glucagonoma / surgery. Humans. Liver Neoplasms / secondary. Lymphatic Metastasis. Malignant Carcinoid Syndrome / diagnosis. Malignant Carcinoid Syndrome / surgery. Multicenter Studies as Topic. Pancreatectomy. Postoperative Care. Postoperative Complications. Prognosis. Somatostatinoma / diagnosis. Somatostatinoma / surgery. Vipoma / diagnosis. Vipoma / surgery

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  • (PMID = 16142076.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 236
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29. Heimann DM, Schwartzentruber DJ: Gastrointestinal perforations associated with interleukin-2 administration. J Immunother; 2004 May-Jun;27(3):254-8
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  • High-dose interleukin-2 (IL-2) results in objective clinical regression in up to 17% of patients with metastatic melanoma and renal cell carcinoma, with about half of these patients experiencing a complete regression of all lesions.
  • In addition, a review of the published English literature on GI perforation in conjunction with IL-2 therapy was performed.
  • These patients developed various signs and symptoms of GI perforation.
  • Six patients developed abdominal pain, yet only two of the eight patients had a fever.
  • All six patients who underwent radiographic evaluation prior to diagnosis had free intraperitoneal air seen on the study.
  • The location of the perforation included the stomach, small bowel, appendix, and colon.
  • All underwent surgical treatment successfully, and four patients received further IL-2 therapy after recovering from the perforation.
  • The key to early diagnosis of GI perforation during IL-2 therapy is radiographic evaluation.
  • Patients with GI perforation can be safely retreated with IL-2 if they are given adequate time to recover from their surgical intervention and if careful assessment is performed to rule out residual infection.
  • [MeSH-major] Digestive System / drug effects. Interleukin-2 / adverse effects. Interleukin-2 / therapeutic use. Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Carcinoma, Renal Cell / drug therapy. Female. Gastrointestinal Diseases / etiology. Humans. Male. Melanoma / drug therapy. Middle Aged

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  • (PMID = 15076143.001).
  • [ISSN] 1524-9557
  • [Journal-full-title] Journal of immunotherapy (Hagerstown, Md. : 1997)
  • [ISO-abbreviation] J. Immunother.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-2
  • [Number-of-references] 20
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30. Kobayashi O, Murakami H, Yoshida T, Cho H, Yoshikawa T, Tsuburaya A, Sairenji M, Motohashi H, Sugiyama Y, Kameda Y: Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center. World J Surg; 2004 Jun;28(6):548-51
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  • [Title] Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center.
  • The clinical features of metastatic gastric tumors (MGTs) have not been well documented.
  • Among 2579 patients with gastric tumors seen between 1992 and 2001, we studied 9 (0.3%) patients with MGT according to a prospective database.
  • The primary tumors included one each of squamous cell carcinoma of the esophagus, signet-ring cell carcinoma of the breast, large-cell or small-cell carcinoma of the lung, renal cell carcinoma, hepatocellular carcinoma, squamous cell or epidermoid carcinoma of the uterus, and melanoma.
  • Although six patients underwent gastrectomy, macroscopic eradication of gastric metastatic disease was accomplished in only four, in whom a UICC R0 resection was possible in only two.
  • Five patients were treated by chemotherapy with no apparent survival benefit.
  • A median survival after MGT diagnosis was 170 days (range 16-892 days) for all cases, 384 days for those who underwent gastrectomy (n = 6), and 27 days for those without active treatment (n = 3) (p = 0.002).
  • [MeSH-major] Stomach Neoplasms / diagnosis. Stomach Neoplasms / mortality

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  • (PMID = 15366743.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Iwamuro M, Tanaka S, Bessho A, Takahashi H, Ohta T, Takada R, Murakami I: Two cases of primary small cell carcinoma of the stomach. Acta Med Okayama; 2009 Oct;63(5):293-8
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  • [Title] Two cases of primary small cell carcinoma of the stomach.
  • We report 2 cases of small cell carcinoma (SmCC) of the stomach with distant metastasis that were treated with the same chemotherapeutic regimens as used to treat small cell lung cancer.
  • Although the mean survival of patients with SmCC of the stomach is reported to be only 7 months, our patients survived for 15 and 14 months, respectively.
  • In our experience, these chemotherapeutic regimens might provide a survival benefit for patients with SmCC of the stomach, although they demonstrated no remarkable antitumor effects.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Aged. Fatal Outcome. Female. Humans. Lymphatic Metastasis. Male. Small Cell Lung Carcinoma / drug therapy. Survival Rate

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  • (PMID = 19893606.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. De Pas T, Sbanotto A, Catania C, Banfi MG, Curigliano G, Nolè F, Fazio N, Formica V, Veronesi G, de Braud F: Oral administration of vinorelbine can overcome intractable endovenous-vinorelbine-associated acute tumor pain. Support Care Cancer; 2005 Mar;13(3):194-5
Hazardous Substances Data Bank. VINBLASTINE .

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  • [MeSH-major] Pain, Intractable / drug therapy. Vinblastine / administration & dosage. Vinblastine / analogs & derivatives
  • [MeSH-minor] Acute Disease. Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Administration, Oral. Aged. Carcinoma, Non-Small-Cell Lung / complications. Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Non-Small-Cell Lung / therapy. Dose-Response Relationship, Drug. Drug Administration Schedule. Follow-Up Studies. Humans. Infusions, Intravenous. Lung Neoplasms / complications. Lung Neoplasms / diagnosis. Lung Neoplasms / therapy. Male. Middle Aged. Pain Measurement. Severity of Illness Index. Stomach Neoplasms / complications. Stomach Neoplasms / diagnosis. Stomach Neoplasms / therapy

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  • (PMID = 15761704.001).
  • [ISSN] 0941-4355
  • [Journal-full-title] Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
  • [ISO-abbreviation] Support Care Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; Q6C979R91Y / vinorelbine
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33. Chaudhary UB, Taksey JD, Johnson RD, Lewin DN: Small-cell cancers, and an unusual reaction to chemotherapy: Case 3. Small-cell carcinoma of the stomach. J Clin Oncol; 2003 Jun 15;21(12):2441-2
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  • [Title] Small-cell cancers, and an unusual reaction to chemotherapy: Case 3. Small-cell carcinoma of the stomach.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Small Cell / pathology. Stomach Neoplasms / pathology

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  • (PMID = 12805346.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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