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Items 1 to 34 of about 34
1. Sim HL, Tan KY, Poon PL, Cheng A: Primary rectal signet ring cell carcinoma with peritoneal dissemination and gastric secondaries. World J Gastroenterol; 2008 Apr 7;14(13):2118-20
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  • [Title] Primary rectal signet ring cell carcinoma with peritoneal dissemination and gastric secondaries.
  • Disseminated signet ring cell carcinomas frequently arise from the stomach.
  • Biopsy of the lesions revealed signet ring cell adenocarcinoma.
  • Gastroscopy showed multiple nodules with ulceration over several areas of the stomach which were similar in appearance to the colonic lesions.
  • However, no primary tumour of the stomach was seen.
  • Biopsy of the gastric lesions also showed signet ring cell adenocarcinoma.
  • Computed tomography scan of the abdomen and pelvis revealed circumferential tumour at the rectosigmoid junction with possible invasion into the left ischiorectal fossa.
  • The overall picture was that of a primary rectal signet ring cell carcinoma with peritoneal dissemination.
  • The patient was referred for palliative chemotherapy in view of the disseminated disease.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / pathology. Colonoscopy / methods. Peritoneum / pathology. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Female. Humans. Stomach Neoplasms / secondary

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  • (PMID = 18395918.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2701538
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2. Ruiz-Hernández G, Delgado-Bolton RC, Rubio-Pérez MJ, Jiménez-Vicioso A, Pérez-Castejón MJ, Carreras-Delgado JL: [Recurrent signet-ring cell gastric carcinoma evidenced by FDG-PET]. Rev Esp Med Nucl; 2005 Sep-Oct;24(5):326-30
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  • [Title] [Recurrent signet-ring cell gastric carcinoma evidenced by FDG-PET].
  • [Transliterated title] Recurrencia de un carcinoma gástrico de células en anillo de sello demostrada por PET-FDG.
  • OBJECTIVE: To present the case report of a patient with undifferentiated and diffuse signet-ring cell gastric carcinoma in which FDG-PET evidenced recurrent disease.
  • MATERIALS AND METHODS: The patient was diagnosed of a stage III gastric carcinoma in 1994 and was treated with a subtotal gastrectomy.
  • The patient was treated with chemotherapy and radiotherapy, reaching a complete response.
  • CONCLUSIONS: In this case report we stress the importance of early recurrence by FDG-PET in a non-intestinal gastric carcinoma.
  • [MeSH-major] Carcinoma, Signet Ring Cell / radionuclide imaging. Fluorodeoxyglucose F18. Neoplasm Recurrence, Local / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Stomach Neoplasms / radionuclide imaging

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  • (PMID = 16194466.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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3. Hornung M, Vogel P, Schubert T, Schlitt HJ, Bolder U: A case of virilization induced by a Krukenberg tumor from gastric cancer. World J Surg Oncol; 2008;6:19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of virilization induced by a Krukenberg tumor from gastric cancer.
  • BACKGROUND: The Krukenberg tumor represents ovarian metastases associated with gastric cancer or other gastrointestinal malignancies.
  • Histology shows typical mucus-production and numerous signet-ring cells.
  • CASE PRESENTATION: Here we report a case of virilization associated with an extensive gastric adenocarcinoma and Krukenberg tumor in a premenopausal woman.
  • Virilization occurred three months after diagnosis of gastric cancer and the ovarian tumors.
  • Palliative chemotherapy was initiated as primary therapy, but gastric outlet obstruction required a gastrojejunostomy.
  • In addition, oopherectomy was performed to relieve abdominal tension and to abate hormonal effects.
  • CONCLUSION: Despite the limitation in survival time early oopherectomy should be considered to prevent the development of virilization even in palliative situations if a Krukenberg tumor is diagnosed with gastric cancer.
  • [MeSH-major] Carcinoma, Signet Ring Cell / therapy. Krukenberg Tumor / therapy. Ovarian Neoplasms / therapy. Virilism / etiology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Fatal Outcome. Female. Gastric Bypass. Gastric Outlet Obstruction / etiology. Gastric Outlet Obstruction / surgery. Humans. Ovariectomy. Palliative Care. Premenopause. Stomach Neoplasms / pathology

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  • (PMID = 18279511.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2275731
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4. Funk L, Hartmann D, Apel D, Spiethoff A, Schiele R, Schilling D, Adamek HE, Riemann JF: [Symptomatic pericardial effusion as initial manifestation of gastric signet ring cell carcinoma]. Dtsch Med Wochenschr; 2003 Apr 17;128(16):870-3
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  • [Title] [Symptomatic pericardial effusion as initial manifestation of gastric signet ring cell carcinoma].
  • The health history included the diagnosis of diabetes mellitus and chronic obstructive pulmonary disease.
  • The cytology showed signet ring cells from the stomach.
  • The histopathological examination diagnosed cancer of diffuse type according to Lauren, with signet-ring cells.
  • TREATMENT AND CLINICAL COURSE: After treating the atrial fibrillation a pericardial drainage was performed.
  • During the clinical course the patient suffered a stroke and the chemotherapy could not be initiated.
  • The patient died 2 months after diagnosis.
  • Echocardiography and pericardiocentesis are helpful for the diagnosis of cardiac metastases.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Pericardial Effusion / etiology. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Atrial Fibrillation / diagnosis. Atrial Fibrillation / etiology. Atrial Fibrillation / therapy. Drainage. Dyspnea. Fatal Outcome. Female. Gastroscopy. Humans. Pericardiocentesis. Tachycardia

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  • (PMID = 12701032.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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5. Kusaba H, Fujihara M, Nagashima R, Kaji Y, Baba E, Nakano S: Systemic chemotherapy of TS-1 and cisplatin for gastric signet-ring cell carcinoma presenting as cardiac tamponade. Med Oncol; 2008;25(2):241-4
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  • [Title] Systemic chemotherapy of TS-1 and cisplatin for gastric signet-ring cell carcinoma presenting as cardiac tamponade.
  • An endoscopic study revealed gastric cancer in the lesser curvature wall of the middle body of the stomach, and signet-ring cell carcinoma was confirmed histologically.
  • The gastric cancer was complicated by malignant pericardial effusion, and metastasis to the mediastinal lymph nodes.
  • The patient was treated with pericardiocentesis followed by systemic chemotherapy consisting of TS-1 and cisplatin (CDDP).
  • After 5 months, pericardial effusion disappeared and the primary gastric tumor decreased in size.
  • Our experience suggests that the systemic chemotherapy of TS-1 and CDDP may be effective for controlling advanced gastric signet-cell carcinoma accompanied by malignant pericardial effusion.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Cardiac Tamponade / etiology. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Cisplatin / administration & dosage. Drug Combinations. Humans. Male. Middle Aged. Oxonic Acid / administration & dosage. Tegafur / administration & dosage

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  • (PMID = 18488163.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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6. Warmerdam FA, Blaauwgeers JL, de Valk B, Roozendaal KJ: [A gastric signet ring cell carcinoma as the first expression of a breast carcinoma]. Ned Tijdschr Geneeskd; 2003 May 17;147(20):980-4
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  • [Title] [A gastric signet ring cell carcinoma as the first expression of a breast carcinoma].
  • Further examination showed linitis plastica due to a signet ring cell carcinoma in the stomach, multiple bone metastases, and an occult, small breast tumour.
  • Immunohistochemical comparison of the tumours strongly suggested that all cases involved a metastasised breast carcinoma.
  • At check-up after one year of tamoxifen treatment, the complaints had disappeared and the activity of the tumour marker had dropped.
  • Gastric metastases from breast carcinoma are rare.
  • Nevertheless, this possibility should be kept in mind in women presenting with malignancies of the stomach and mastopathy.
  • Hormonal treatment and chemotherapy may result in reasonable palliation.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Signet Ring Cell / diagnosis. Stomach Neoplasms / secondary
  • [MeSH-minor] Aged. Antineoplastic Agents, Hormonal / therapeutic use. Bone Neoplasms / diagnosis. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Diagnosis, Differential. Female. Humans. Tamoxifen / therapeutic use

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  • (PMID = 12784534.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen
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7. Karayiannakis AJ, Bolanaki H, Tsalikidis C, Simopoulos C: Cutaneous metastasis at a surgical drain site after gastric cancer resection. Case Rep Oncol; 2010 Sep;3(3):495-7

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  • [Title] Cutaneous metastasis at a surgical drain site after gastric cancer resection.
  • Cutaneous metastasis from intra-abdominal malignant solid tumours such as gastric adenocarcinoma is very rare.
  • Here, we report the case of a 76-year-old male patient with a T4N2M0, poorly differentiated, signet-ring cell gastric carcinoma, who underwent potentially curative resection of the tumour and developed cutaneous metastasis at the site of the surgical drain 4 months after the operation while he was on chemotherapy.
  • It is concluded that the development of cutaneous metastasis after gastric carcinoma resection indicates tumour recurrence or disseminated disease and is associated with poor prognosis.

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  • (PMID = 21611104.001).
  • [ISSN] 1662-6575
  • [Journal-full-title] Case reports in oncology
  • [ISO-abbreviation] Case Rep Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3100273
  • [Keywords] NOTNLM ; Abdominal wall metastasis / Gastric carcinoma / Skin metastasis / Wound implantation
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8. Yoshida M, Matsuda H, Furuya K: Successful treatment of gastric cancer in pregnancy. Taiwan J Obstet Gynecol; 2009 Sep;48(3):282-5
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  • [Title] Successful treatment of gastric cancer in pregnancy.
  • OBJECTIVE: Gastric cancer during pregnancy is rare, and even in Japan where a high rate of gastric cancers are reported, only 0.016% of pregnant women suffer from this disease.
  • Generally, the cancer is already advanced at the time of detection and the prognosis for the woman is usually extremely poor.
  • Moreover, prioritizing treatment of the woman often results in a premature birth.
  • CASE REPORT: We report a case of gastric cancer in a 32-year-old pregnant woman, gravida 6, para 4.
  • The mother and the neonate had good prognoses after early diagnosis, cesarean delivery and surgery.
  • CONCLUSION: Diagnosis of gastric cancer in pregnant women is often delayed even when they are symptomatic, because the symptoms are taken to be symptoms of hyperemesis or expansion of the uterus.
  • This case highlights the importance of early detection of gastric cancer for a positive prognosis, considering the rapidity with which gastric cancer advances in pregnancy.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Signet Ring Cell / surgery. Pregnancy Complications, Neoplastic / surgery. Pregnancy Outcome. Stomach Neoplasms / surgery

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  • (PMID = 19797021.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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9. Zhang BL, Xu RL, Zheng X, Qin YW: A case with cardiac tamponade as the first sign of primary gastric signet-ring cell carcinoma treated with combination therapy. Med Sci Monit; 2010 Apr;16(4):CS41-44
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  • [Title] A case with cardiac tamponade as the first sign of primary gastric signet-ring cell carcinoma treated with combination therapy.
  • BACKGROUND: This report presents a rare patient with cardiac tamponade as the first manifestation of primary gastric signet-ring cell carcinoma.
  • The endoscopic examination of the stomach disclosed gastric cancer in the posterior wall of the antrum and the biopsy showed signet-ring cell carcinoma.
  • The gastric cancer was complicated by malignant pericardial effusion and pleural effusion as well as metastasis to the peripheral lymph nodes and bones.
  • The patient was treated with percutaneous pericardiocentesis followed by systemic chemotherapy (oxaliplatin and sequential 5-fluorouracil plus leucovorin).
  • CONCLUSIONS: Cardiac tamponade may originate from a primary gastric signet-ring cell carcinoma.
  • Pericardiocentesis followed by systemic chemotherapy may be effective in controlling such advanced gastric signet-ring cell carcinoma.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / drug therapy. Cardiac Tamponade / complications. Cardiac Tamponade / diagnosis. Stomach Neoplasms / diagnosis. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Middle Aged. Neoplasm Metastasis. Organoplatinum Compounds / administration & dosage. Treatment Outcome

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  • (PMID = 20357721.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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10. Mizoshita T, Kataoka H, Kubota E, Okamoto Y, Shimura T, Mori Y, Wada T, Ogasawara N, Sasaki M, Kamiya T, Joh T: Gastric phenotype signet-ring cell carcinoma of the stomach with multiple bone metastases effectively treated with sequential methotrexate and 5-fluorouracil. Int J Clin Oncol; 2008 Aug;13(4):373-6
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  • [Title] Gastric phenotype signet-ring cell carcinoma of the stomach with multiple bone metastases effectively treated with sequential methotrexate and 5-fluorouracil.
  • Computed tomography (CT) scan of the abdomen and pelvis and radioisotope (RI) examination led to a strong suspicion of systemic bone metastatic tumors, although the origin was not known.
  • Biopsies from bone metastatic lesions in the left ilium were performed under CT scan, and signet-ring cell carcinoma cells were detected pathologically.
  • Also, a 0-IIc-like lesion was observed endoscopically in the stomach, and signet-ring cell carcinoma cells were also detected histologically.
  • Both the stomach and the bone metastatic lesions exhibited a gastric phenotype (G type) phenotypically.
  • From these findings, we diagnosed the patient as having advanced (inoperable) stomach cancer with multiple bone metastases; she also exhibited disseminated intravascular coagulation (DIC).
  • We treated her with sequential methotrexate and 5-fluorouracil (sequential MTX/5-FU) therapy after obtaining her informed consent.
  • After six cycles of the chemotherapy, the abnormal ALP and Plt levels were alleviated.
  • At present, she is receiving weekly sequential MTX/5-FU therapy at the outpatient oncology unit; she has been receiving the therapy for about 7 months since the detection of the bone metastases and has had a total of 17 cycles.
  • In conclusion, sequential MTX/5-FU therapy was effective for a patient with G-type signet-ring cell carcinoma of the stomach with bone metastases, suggesting that the phenotypic classification may be one of the useful markers for prediction of the effectiveness of chemotherapy in patients with inoperable advanced stomach cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Carcinoma, Signet Ring Cell / drug therapy. Carcinoma, Signet Ring Cell / secondary. Stomach Neoplasms / drug therapy

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  • (PMID = 18704642.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] U3P01618RT / Fluorouracil; YL5FZ2Y5U1 / Methotrexate
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11. Romics I, Székely E, Szendroi A: Signet-ring cell carcinoma arising from the urinary bladder. Can J Urol; 2008 Oct;15(5):4266-8
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  • [Title] Signet-ring cell carcinoma arising from the urinary bladder.
  • INTRODUCTION: Signet-ring cell carcinoma of the urinary bladder can be primary - arising from the bladder wall or urachus remnants - or metastatic from tumors originating in the stomach, colon, or breast.
  • Saphir first described primary signet-ring cell cancer of the urinary bladder in 1955.
  • A transurethral biopsy showed signet-ring cell carcinoma.
  • Histological examination showed a primary signet-ring cell carcinoma of the bladder (pT3bN0M0).
  • Following surgery, the patient received adjuvant chemotherapy with cisplatin and fluorouracil.
  • CONCLUSIONS: Primary signet-ring cell carcinoma of the urinary bladder is an extremely rare tumor, accounting for approximately 0.24% of all bladder malignances.
  • Patients with this type of cancer generally have a poor prognosis.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Chemotherapy, Adjuvant. Cystectomy. Cystoscopy. Female. Hematuria / etiology. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18814817.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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12. Zhang M, Zhu G, Zhang H, Gao H, Xue Y: Clinicopathologic features of gastric carcinoma with signet ring cell histology. J Gastrointest Surg; 2010 Apr;14(4):601-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic features of gastric carcinoma with signet ring cell histology.
  • BACKGROUND: Reports of clinicopathological features and prognosis in patients with signet ring cell carcinoma of the stomach (SRC) are conflicting.
  • The aim was to describe the clinicopathological features and prognosis of patients with SRC in comparison with non-signet ring cell carcinoma of the stomach (NSRC).
  • METHODS: In this retrospective study, we reviewed the records of 1,439 consecutive patients diagnosed with gastric carcinoma who were resected surgically from 1993 to 2003.
  • RESULTS: There were significant differences in tumor size, tumor location, macroscopic type, depth on invasion, lymph node metastasis, lymphatic invasion, tumor stage, chemotherapy, and curability between the patients with SRC histology and NSRC.
  • [MeSH-major] Carcinoma, Signet Ring Cell / pathology. Gastrectomy / methods. Stomach Neoplasms / pathology

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  • (PMID = 20033340.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Katase K, Shimizu Y, Kobayashi Y, Hasumi K: [Chemotherapy with combination of UFT and cisplatin against metastatic ovarian tumor originating from gastric cancer]. Gan To Kagaku Ryoho; 2004 Jun;31(6):943-7
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  • [Title] [Chemotherapy with combination of UFT and cisplatin against metastatic ovarian tumor originating from gastric cancer].
  • Krukenberg's tumor, an metastatic ovarian tumor originating from gastric cancer, is a disease with extremely poor prognosis, and it is rare for patients to survive for more than 2 years after the diagnosis.
  • We encountered a patient in whom a long-term good prognosis could be obtained probably because of the effects of chemotherapy after the ovarian tumor extraction.
  • Enhancement of the antitumor effects by the concomitant use of 5-FU and cisplatin has been attracting attention, and the methods of administration of these drugs have been investigated by numerous researchers as FP therapy.
  • It was characteristic to the treatment of our patient that 5-FU was administered in the form of oral UFT.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Administration, Oral. Adult. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Routes. Female. Humans. Hysterotomy. Ovariectomy. Prognosis. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 15222118.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q20Q21Q62J / Cisplatin; FP protocol
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14. Akatsu Y, Saikawa Y, Kubota T, Yoshida M, Furukawa T, Otani Y, Kumai K, Kitajima M: Clinical and pathological disappearance of peritoneal dissemination in a patient with advanced gastric cancer receiving chemotherapy with S-1 and low-dose cisplatin. Gastric Cancer; 2004;7(2):128-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and pathological disappearance of peritoneal dissemination in a patient with advanced gastric cancer receiving chemotherapy with S-1 and low-dose cisplatin.
  • Cytological examination revealed adenocarcinoma cells, leading to a diagnosis of peritonitis carcinomatosa.
  • Gastrointestinal fiberscopy (GIF) resulted in a histological diagnosis of type 4 advanced gastric cancer with signet-ring cell carcinoma.
  • The clinical diagnosis was confirmed to be cT3(SE)cN1cM0cH0cP1, cStage IV gastric cancer, type 4, according to the Japanese classification of gastric carcinoma.
  • The patient was treated with S-1 and low-dose cisplatin (CDDP) in order to alleviate the critical state of the disease.
  • Total gastrectomy with D1 lymph node dissection was performed, and the surgical diagnosis was sT3(SE)sN0sM0sH0sP0; sStage II.
  • Microscopically, viable cancer cells were found to be scattered throughout the subserosal-serosal layers in the resected stomach.
  • All of the samples from lesions that were potentially cancers involving peritoneal dissemination were diagnosed as fibrous scar tissues without any viable cancer cells.
  • The patient is alive without recurrence at 10 months after surgery and 14 months after the initial chemotherapy.
  • Thus, systemic chemotherapy with S-1/low-dose CDDP achieved desirable control of peritoneal disseminated cells, as assessed microscopically, suggesting that the regimen may be an effective strategy for the treatment of advanced gastric cancer with peritonitis carcinomatosa.
  • [MeSH-major] Ascites / diagnosis. Carcinoma, Signet Ring Cell / drug therapy. Cisplatin / therapeutic use. Oxonic Acid / therapeutic use. Pyridines / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use
  • [MeSH-minor] Drug Combinations. Drug Therapy, Combination. Female. Humans. Middle Aged. Neoplasm Staging

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  • (PMID = 15224201.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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15. Kuriyama H, Nonaka T, Sawatari T, Tsuboi H, Akanuma M, Hata Y: [A case of advanced gastric cancer with peritoneal dissemination effectively treated by combined chemotherapy of paclitaxel (TXL) and TS-1]. Gan To Kagaku Ryoho; 2005 May;32(5):663-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of advanced gastric cancer with peritoneal dissemination effectively treated by combined chemotherapy of paclitaxel (TXL) and TS-1].
  • Chemotherapy was conducted combining paclitaxel (TXL) and TS-1 under the diagnosis of non-resectable advanced gastric cancer with peritoneal dissemination.
  • Ascites fluid was reduced after completion of the 1st cycle, and the therapeutic efficacy was rated as PR.
  • Abdominal fullness was relieved shortly after starting the treatment, making it possible to conduct treatment on an ambulatory basis in the 2nd and subsequent cycles.
  • At present, 6 months after starting chemotherapy, there is no evidence of relapse or adverse reactions that require intervention.
  • Chemotherapy is being continued on an ambulatory basis.
  • Combination of TXL and TS-1 is expected to show good therapeutic efficacy and improve patients' QOL in patients with gastric cancer associated with peritoneal dissemination.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Peritoneal Neoplasms / secondary. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Drug Administration Schedule. Drug Combinations. Female. Humans. Middle Aged. Oxonic Acid / administration & dosage. Paclitaxel / administration & dosage. Pyridines / administration & dosage. Quality of Life. Tegafur / administration & dosage

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  • (PMID = 15918568.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; P88XT4IS4D / Paclitaxel
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16. Dempke W, von Poblozki A, Kellner O, Wolf HH, Schmoll HJ: [Hemorrhagic diathesis as initial symptom of stomach carcinoma]. Wien Klin Wochenschr; 2000 Dec 22;112(24):1053-8
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  • [Title] [Hemorrhagic diathesis as initial symptom of stomach carcinoma].
  • Gastroscopy revealed a 2 cm ulcer at the back side of the gastric corpus.
  • Histologically, a signet-ring cell carcinoma was diagnosed.
  • Final diagnosis stated a multilocular metastasising gastric cancer with infiltration of bone, peritoneum and dura and signet-cell infiltration of the bone marrow.
  • Parallel to initial symptomatic therapy of coagulopathy, systemic cytostatic therapy with CDDP and VP-16 was initiated.
  • After histologic confirmation of the diagnosis, weekly therapy with 5-FU (2600 mg/m2) and folinic acid (500 mg/m2) according to the Ardalan protocol was performed.
  • Although the chemotherapy dose had to be reduced due to prolonged neutropenia, the disturbances of hemostasis resolved completely resulting in reduced substitution rates with fresh frozen plasma (FFP) and platelets.
  • However, it should be followed by specific therapy of malignancy, since tumor-induced metabolites (e.g. mucin) maintain the alteration of hemostasis.
  • Chemotherapy may therefore be the best strategy to prevent complications such as MAHA and DIC.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Hemorrhagic Disorders / etiology. Precancerous Conditions / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Anemia, Hemolytic / diagnosis. Anemia, Hemolytic / etiology. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow / pathology. Bone Marrow Neoplasms / pathology. Bone Marrow Neoplasms / secondary. Cisplatin / administration & dosage. Diagnosis, Differential. Disseminated Intravascular Coagulation / diagnosis. Disseminated Intravascular Coagulation / etiology. Etoposide / therapeutic use. Female. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Middle Aged. Neoplasm Metastasis. Stomach / pathology. Thrombocytopenia / diagnosis

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  • (PMID = 11204317.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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17. Parvez T, Mahrous AR, Abdullah BN: Gastric stump carcinoma. J Coll Physicians Surg Pak; 2005 Aug;15(8):502-4
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  • [Title] Gastric stump carcinoma.
  • This case report describes the occurrence of carcinoma in gastric stump in a man who underwent partial gastrectomy with anastomosis 20 years back for duodenal ulcer.
  • Surgical resection and anastomosis was followed by adjuvant chemotherapy.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / surgery. Gastric Stump. Stomach Neoplasms / diagnosis. Stomach Neoplasms / surgery
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Male

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  • (PMID = 16202366.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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18. Jansen M, Büchin P, Dreuw B, Fass J, Minkenberg R, Mehring M, Schumpelick V: [Prognostic factors for development of peritoneal carcinosis in stomach carcinoma]. Chirurg; 2001 May;72(5):561-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Prognostic factors for development of peritoneal carcinosis in stomach carcinoma].
  • OBJECTIVE: Several adjuvant therapy concepts have been developed to improve the treatment of gastric cancer patients.
  • Dealing with intraperitoneal chemotherapy, it seems to be useful to determine suitable prognostic factors for the occurrence of peritoneal carcinosis, as it is possible to select patients who may profit from this therapy.
  • METHODS: Between June 1975 and December 1999 resection of gastric cancer was performed in 575 patients.
  • From 1 January 1986 clinical data were recorded prospectively, before that time, retrospectively.
  • The complete data concerning preoperative diagnosis, operation, histology, postoperative course and survival time were documented in an Excel file for statistical analysis.
  • RESULTS: Significant correlation was found between the occurrence of peritoneal dissemination and tumour stage pT3, pN2, G3, cancer of the whole stomach and cancer at the anastomotic site after partial gastric resection.
  • Lauren classification, signet-ring cell cancer, liver metastasis and tumour localisation in the distal or proximal stomach showed no significant correlation to peritoneal carcinosis in the multivariate analysis.
  • The present data serve as a basis for further histochemical and molecular biological investigations e.g. of the expression of adhesion molecules to determine the risk of peritoneal tumour dissemination after gastric cancer.
  • [MeSH-major] Peritoneal Neoplasms / secondary. Stomach Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Gastrectomy. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Patient Selection. Prospective Studies. Survival Rate

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  • (PMID = 11383068.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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19. Raderer M, Püspök A, Stummvoll G, Längle F, Chott A: Early cancer of the stomach arising after successful treatment of gastric MALT lymphoma in patients with autoimmune disease. Scand J Gastroenterol; 2003 Mar;38(3):294-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early cancer of the stomach arising after successful treatment of gastric MALT lymphoma in patients with autoimmune disease.
  • BACKGROUND: Extranodal marginal zone B-cell lymphoma of the mucosa associated lymphoid tissue (MALT lymphoma) arises in lymphoid tissue acquired through chronic antigenic stimulation as exemplified by Helicobacter pylori.
  • Secondary development of gastric cancer, however, is thought to be a rare event.
  • The detection of a signet ring cell carcinoma during follow-up endoscopy after successful therapy of MALT lymphoma in a patient with Sjögren's syndrome prompted us to analyse the frequency of subsequent gastric cancer in patients with underlying autoimmune disease (AD).
  • METHODS: Patients with early stage MALT lymphoma and an underlying AD were evaluated for the occurrence of a secondary gastric cancer during the course of follow-up.
  • Data analysed included the type of AD, stage of MALT lymphoma, H. pylori status, treatment for MALT lymphoma and response, follow-up, the presence of a secondary cancer, and time to development of cancer.
  • In all patients, histologic samples were reassessed for the extent of gastritis, presence of intestinal metaplasia or focal atrophy at the time of lymphoma diagnosis.
  • RESULTS: A total of eight patients with overt AD at the time of diagnosis of MALT lymphoma were identified.
  • All patients had early stage MALT lymphoma restricted to the mucosa and submucosa at the time of diagnosis, and the presence of H. pylori was found in all cases.
  • Two of these patients achieved complete remission (CR) of the lymphoma following H. pylori eradication, while six were judged unresponsive and underwent chemotherapy, resulting in CR in all cases.
  • One patient died from stroke while being in CR for 2 months following chemotherapy.
  • Two patients (25%) developed early cancer limited to the gastric mucosa while being in CR from lymphoma for 9 and 27 months, respectively, and underwent partial gastrectomy.
  • Final staging of gastric cancer revealed pT1pN0M0 in both cases.
  • In the remaining 4 patients, no evidence of lymphoma recurrence or a second malignancy has been found so far by regular follow-up every 3 months for a time-span between 52 and 63 months after initial diagnosis.
  • CONCLUSION: Patients with concurrent MALT lymphoma and an underlying autoimmune condition show not only an impaired response to H. pylori eradication but might also be at increased risk for the development of gastric cancer.
  • [MeSH-major] Autoimmune Diseases / therapy. Gastric Mucosa / pathology. Lymphoma, B-Cell, Marginal Zone / therapy. Stomach Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Aged. Antineoplastic Combined Chemotherapy Protocols. Austria. Biopsy. Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / therapy. Endosonography. Female. Follow-Up Studies. Humans. Metaplasia. Middle Aged. Neoplasm Staging. Polymyalgia Rheumatica / diagnosis. Polymyalgia Rheumatica / therapy. Pyloric Antrum / pathology. Remission Induction. Severity of Illness Index. Sjogren's Syndrome / diagnosis. Sjogren's Syndrome / therapy. Time Factors. Treatment Outcome

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  • (PMID = 12737445.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Norway
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20. Kleikamp S, Böhm M, Frosch P, Brinkmeier T: [Acanthosis nigricans, papillomatosis mucosae and "tripe palms" in a patient with metastasized gastric carcinoma]. Dtsch Med Wochenschr; 2006 May 26;131(21):1209-13
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  • [Title] [Acanthosis nigricans, papillomatosis mucosae and "tripe palms" in a patient with metastasized gastric carcinoma].
  • [Transliterated title] Acanthosis nigricans, Papillomatosis mucosae und "tripe palms" bei einem Patienten mit metastasiertem Magenkarzinom.
  • Gastroscopic findings were suspicious of adenocarcinoma of the stomach: it was classified histologically as a signet-ring cell, non-mucinous adenocarcinoma.
  • At the time of diagnosis the tumor had already metastasized to perigastric and peripancreatic lymph nodes with peritoneal carcinosis.
  • TREATMENT AND COURSE: Since a curative resection was impossible a gastrojejunostomy was carried out.
  • After this the patient received several courses of chemotherapy according to different schemes.
  • Serum tumor marker levels and cutaneous signs regressed several times.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Skin Diseases / etiology. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology
  • [MeSH-minor] Acanthosis Nigricans / diagnosis. Acanthosis Nigricans / etiology. Antigens, Tumor-Associated, Carbohydrate / blood. Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Fatal Outcome. Humans. Immunohistochemistry. Keratoderma, Palmoplantar / diagnosis. Keratoderma, Palmoplantar / etiology. Lymphatic Metastasis. Male. Middle Aged. Mouth Neoplasms / diagnosis. Mouth Neoplasms / etiology. Obesity / complications. Papilloma / diagnosis. Papilloma / etiology. Peritoneal Neoplasms / secondary. Receptor, Melanocortin, Type 1 / analysis

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  • (PMID = 16721709.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / CA-72-4 antigen; 0 / Carcinoembryonic Antigen; 0 / Receptor, Melanocortin, Type 1
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21. Lordick F, Grenacher L, Röcken C, Ebert M, Moehler M, Schumacher G: [Diagnosis and treatment of gastric cancer]. Dtsch Med Wochenschr; 2010 Aug;135(34-35):1671-82; quiz 1683-6
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  • [Title] [Diagnosis and treatment of gastric cancer].
  • [Transliterated title] Diagnostik und Therapie des Magenkarzinoms.
  • From a global perspective, gastric cancer including cancer of the esophago-gastric junction is the fourth most common malignant tumor and the second-most common cause of cancer-related death.
  • Due to the lack of screening programs in Western countries, most gastric cancers are diagnosed in advanced stages.
  • A sophisticated staging should include high-resolution computed tomography of the thorax, abdomen and pelvis and video-documented endoscopy and endoscopic ultrasound.
  • In mucosal gastric cancer, endoscopic resection can replace surgical resection if specific criteria are present.
  • In the stages II and III perioperative chemotherapy has been established as a standard of care and should be applied.
  • In the metastatic setting, treatment goals are palliative.
  • Chemotherapy can prolong survival, improve symptoms and can help to maintain a better quality of life.
  • Combination chemotherapy including a platinum compound and a fluoropyrimidine regarded as standard.
  • About 20 % of gastric cancers exhibit overexpression of the growth factor receptor family member Her2.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Cisplatin / administration & dosage. Endoscopy, Digestive System. Epirubicin / administration & dosage. Esophagectomy. Fluorouracil / administration & dosage. Gastrectomy. Gastric Mucosa / pathology. Humans. Laparoscopy. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoadjuvant Therapy. Neoplasm Invasiveness. Neoplasm Staging. Neoplasm, Residual / diagnosis. Neoplasm, Residual / pathology. Tomography, X-Ray Computed

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  • [Copyright] Georg Thieme Verlag KG Stuttgart-New York.
  • (PMID = 20721843.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 3Z8479ZZ5X / Epirubicin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; FPEPIR regimen
  • [Number-of-references] 40
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22. Deguchi Y, Nashimoto A, Yabusaki H, Tanaka O, Sasaki J: [A case of remnant gastric cancer responding to neoadjuvant TS-1 therapy]. Gan To Kagaku Ryoho; 2001 Oct;28(10):1449-52
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  • [Title] [A case of remnant gastric cancer responding to neoadjuvant TS-1 therapy].
  • We report the case a 77-year-old male with remnant gastric cancer successfully treated with TS-1 as neoadjuvant chemotherapy.
  • His treatment was daily oral administration of 100 mg TS-1 for 28 days.
  • This therapy was safely carried out on an outpatient basis.
  • The histological diagnosis of the resected stomach revealed complete disappearance of cancer cells in the stomach and the regional lymph nodes.
  • This case suggests that TS-1 may have a potent therapeutic effect in neoadjuvant chemotherapy for recurrent gastric cancer.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Gastric Stump. Oxonic Acid / therapeutic use. Pyridines / therapeutic use. Stomach Neoplasms / drug therapy. Tegafur / therapeutic use
  • [MeSH-minor] Administration, Oral. Aged. Drug Administration Schedule. Drug Combinations. Humans. Male. Neoadjuvant Therapy

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  • (PMID = 11681256.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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23. Harting MT, Blakely ML, Herzog CE, Lally KP, Ajani JA, Andrassy RJ: Treatment issues in pediatric gastric adenocarcinoma. J Pediatr Surg; 2004 Aug;39(8):e8-10
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  • [Title] Treatment issues in pediatric gastric adenocarcinoma.
  • Gastric adenocarcinoma is a rare diagnosis in children.
  • Modern treatment includes chemotherapy, radiotherapy, and surgery and has evolved over the past decade.
  • The authors report a case of an 8-year-old girl with gastric adenocarcinoma.
  • [MeSH-major] Camptothecin / analogs & derivatives. Carcinoma, Signet Ring Cell / surgery. Stomach Neoplasms / surgery
  • [MeSH-minor] Anastomosis, Roux-en-Y. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Catheter Ablation. Chemotherapy, Adjuvant. Child. Cisplatin / administration & dosage. Combined Modality Therapy. Female. Fluorouracil / administration & dosage. Gastrectomy. Gastritis / complications. Helicobacter Infections / complications. Helicobacter pylori. Humans. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lymph Node Excision. Neoplasm Recurrence, Local / surgery. Neoplastic Syndromes, Hereditary. Pancreatectomy. Prognosis. Radiation-Sensitizing Agents / administration & dosage. Radiotherapy, Adjuvant. Remission Induction. Reoperation. Splenectomy. Taxoids / administration & dosage

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  • (PMID = 15300556.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiation-Sensitizing Agents; 0 / Taxoids; 15H5577CQD / docetaxel; 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin
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24. Waguri N, Furukawa K, Shobugawa K, Takizawa K, Ikeda H, Iwamoto Y, Aiba T, Yoneyama O, Igarashi K, Tsukioka S, Yabe M, Kuwabara S, Shibuya H: [A case of gastric cancer with abdominal wall invasion treated by weekly low-dose paclitaxel therapy]. Gan To Kagaku Ryoho; 2006 Aug;33(8):1151-4
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  • [Title] [A case of gastric cancer with abdominal wall invasion treated by weekly low-dose paclitaxel therapy].
  • Here we report a case of gastric cancer with diffuse abdominal wall invasion treated with weekly low-dose paclitaxel therapy.
  • Computed tomography revealed diffuse swelling of the abdominal wall and hydronephrosis of the right kidney.
  • Upper gastrointestinal endoscopy demonstrated type 3' advanced gastric cancer.
  • Pathological diagnosis of both gastric tumor and abdominal wall biopsy specimens was poorly-differentiated adenocarcinoma containing signet ring cell carcinoma.
  • Abdominal wall swelling like cuirass disappeared after 2 courses of low-dose paclitaxel therapy.
  • Nine repeated courses of this regimen have been given until now; the relapse of the abdominal wall invasion has not become apparent, and primary gastric lesion has been a stable disease.
  • Diffuse abdominal wall invasion of gastric cancer like cuirass without ascites is a rare condition, and low-dose paclitaxel was very effective for this condition.
  • [MeSH-major] Abdominal Wall / pathology. Adenocarcinoma / drug therapy. Antineoplastic Agents, Phytogenic / administration & dosage. Paclitaxel / administration & dosage. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Carcinoma, Signet Ring Cell / pathology. Drug Administration Schedule. Humans. Male. Middle Aged. Neoplasm Invasiveness. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 16912538.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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25. Kath R, Fiehler J, Schneider CP, Höffken K: Gastric cancer in very young adults: apropos four patients and a review of the literature. J Cancer Res Clin Oncol; 2000 Apr;126(4):233-7
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  • [Title] Gastric cancer in very young adults: apropos four patients and a review of the literature.
  • Whether gastric cancer in young adults differs from gastric cancer in older patients has been a controversial issue.
  • It has long been suspected that young patients with gastric cancer have different biological features with a more aggressive course of disease and a poorer prognosis than older patients.
  • We report on the clinical course of four patients (three female and one male) with locally advanced (n = 1) or metastasized (n = 3) non-resectable gastric cancer diagnosed under the age of 29 years (23, 25, 27, 28 years).
  • Prior to diagnosis, all three women had recently been pregnant (1-22 months).
  • Diagnosis was endoscopically biopsy-proven and staging work-up was performed by primary explorative surgery (n = 1), laparoscopy and explorative surgery (n = 1) or CAT scan and ultrasound (n = 2).
  • The delay between initial symptoms and diagnosis was 8-22 weeks (median, 10 weeks).
  • The histology was signet-ring cell (n = 2) or undifferentiated (n = 2) gastric cancer.
  • All patients had the diffuse type of gastric cancer according to Lauren.
  • The best response after chemotherapy was partial in two patients.
  • Three patients died 6, 4 and 8 months after diagnosis.
  • In our series, very young adults with gastric cancer had adverse clinical and pathological features.
  • Though the delay between the first symptoms and diagnosis in our patients was no different from that reported for older patients, special emphasis should be given to prompt referral and diagnostic investigations, ensuring the diagnosis of gastric cancer early in the course of disease.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Adult. Age Factors. Cisplatin / therapeutic use. Doxorubicin / therapeutic use. Female. Floxuridine / therapeutic use. Helicobacter pylori / isolation & purification. Humans. Leucovorin / therapeutic use. Male. Pregnancy. Pregnancy Complications, Neoplastic. Preoperative Care. Treatment Outcome

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  • (PMID = 10782897.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] GERMANY
  • [Chemical-registry-number] 039LU44I5M / Floxuridine; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; FLAP protocol
  • [Number-of-references] 28
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26. Kobayashi O, Murakami H, Yoshida T, Cho H, Yoshikawa T, Tsuburaya A, Sairenji M, Motohashi H, Sugiyama Y, Kameda Y: Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center. World J Surg; 2004 Jun;28(6):548-51
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  • [Title] Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center.
  • The clinical features of metastatic gastric tumors (MGTs) have not been well documented.
  • Among 2579 patients with gastric tumors seen between 1992 and 2001, we studied 9 (0.3%) patients with MGT according to a prospective database.
  • The primary tumors included one each of squamous cell carcinoma of the esophagus, signet-ring cell carcinoma of the breast, large-cell or small-cell carcinoma of the lung, renal cell carcinoma, hepatocellular carcinoma, squamous cell or epidermoid carcinoma of the uterus, and melanoma.
  • Although six patients underwent gastrectomy, macroscopic eradication of gastric metastatic disease was accomplished in only four, in whom a UICC R0 resection was possible in only two.
  • Five patients were treated by chemotherapy with no apparent survival benefit.
  • A median survival after MGT diagnosis was 170 days (range 16-892 days) for all cases, 384 days for those who underwent gastrectomy (n = 6), and 27 days for those without active treatment (n = 3) (p = 0.002).
  • [MeSH-major] Stomach Neoplasms / diagnosis. Stomach Neoplasms / mortality

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  • (PMID = 15366743.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Won HJ, Ha TK, Kwon SJ, Cho HY, Hur SJ, Baik HH, Suh SI, Ha E, Kim YH: Differential effects of 5-fluorouracil on glucose transport and expressions of glucose transporter proteins in gastric cancer cells. Anticancer Drugs; 2010 Mar;21(3):270-6
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  • [Title] Differential effects of 5-fluorouracil on glucose transport and expressions of glucose transporter proteins in gastric cancer cells.
  • Although 5-fluorouracil (5-FU) is a widely used chemotherapeutic agent in the treatment of gastric cancer, the underlying mechanism for 5-FU resistant phenotype, has yet to be elucidated.
  • We hypothesized that the sensitivity of gastric cancer to 5-FU treatment might be related to the rate of glucose transport (GLUT), and investigated the expressions of GLUT1, 2, 3, and 4 in two different gastric cancer cells (SNU-216, moderately differentiated gastric adenocarcinoma; and SNU-668, signet ring cell gastric carcinoma).
  • We also observed that glycogen synthase kinase 3 activity was decreased in SNU-216 and increased in SNU-668 with 5-FU treatment.
  • No significant difference in hexokinase activities was observed with 5-FU treatment.
  • Taken together, these results suggest that 5-FU exerts differential effects on GLUT depending on gastric cancer cell types, which may indicate a possible explanation, at least in part, for the differing responses to 5-FU chemotherapy in gastric cancer.
  • [MeSH-major] Antimetabolites, Antineoplastic / pharmacology. Carcinoma, Signet Ring Cell / metabolism. Fluorouracil / pharmacology. Glucose / metabolism. Glucose Transport Proteins, Facilitative / metabolism. Stomach Neoplasms / metabolism
  • [MeSH-minor] Biological Transport / drug effects. Cell Line, Tumor. Glycogen Synthase Kinase 3 / metabolism. Hexokinase / metabolism. Humans

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  • (PMID = 20023572.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Glucose Transport Proteins, Facilitative; EC 2.7.1.1 / Hexokinase; EC 2.7.11.26 / Glycogen Synthase Kinase 3; IY9XDZ35W2 / Glucose; U3P01618RT / Fluorouracil
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28. Palma Modoni A, De Galasso L, Scriccia S, Milanetti F, Sgambato E, Spoto S, Costantino S: [A 52 year-old woman with fever, cough and dyspnoea]. Clin Ter; 2004 Sep;155(9):401-4
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  • A 52 year-old woman with gastric cancer treated with surgery and chemotherapy, is admitted in our Internal Medicine Department because of the presence of fever (max 41.2 degrees C), dyspnoea, non-productive cough and mental confusion.
  • The anamnesis and the physical examination address to the diagnosis of CAP (Community-Acquired Pneumonia); in particular the alteration of consciousness and the onset of symptoms after the insertion of a nose-gastric tube let us to consider the diagnosis of aspiration pneumonia.
  • It can be either idiopathic or associated with a variety of causes, such as infections, drugs, radiations and connective tissue diseases.
  • The gold standard for the diagnosis is represented by lung biopsy with hystopathologic confirmation but, if it cannot be done, it's necessary to start immediately steroid therapy because BOOP may be fatal.
  • The patient received antibiotic and steroid therapy with success.
  • [MeSH-major] Confusion / etiology. Cough / etiology. Cryptogenic Organizing Pneumonia / diagnosis. Dyspnea / etiology. Fever / etiology
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Anti-Bacterial Agents. Carcinoma, Signet Ring Cell / complications. Carcinoma, Signet Ring Cell / secondary. Carcinoma, Signet Ring Cell / surgery. Diagnosis, Differential. Drug Therapy, Combination / therapeutic use. Female. Humans. Intestinal Obstruction / etiology. Intestinal Obstruction / therapy. Intubation, Gastrointestinal / adverse effects. Klebsiella Infections / complications. Klebsiella Infections / drug therapy. Klebsiella oxytoca. Krukenberg Tumor / complications. Krukenberg Tumor / secondary. Krukenberg Tumor / surgery. Middle Aged. Ovarian Neoplasms / complications. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Peritoneal Neoplasms / complications. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Pneumonia, Aspiration / complications. Pneumonia, Bacterial / complications. Pneumonia, Bacterial / drug therapy. Postoperative Complications / etiology. Respiratory Distress Syndrome, Adult / diagnosis. Respiratory Distress Syndrome, Adult / etiology. Respiratory Distress Syndrome, Adult / radiography. Stomach Neoplasms / complications. Stomach Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 15700634.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] Case Reports; Clinical Conference; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Anti-Bacterial Agents
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29. Kim WY, Kim TJ, Kim SE, Lee JW, Lee JH, Kim BG, Bae DS: The role of cytoreductive surgery for non-genital tract metastatic tumors to the ovaries. Eur J Obstet Gynecol Reprod Biol; 2010 Mar;149(1):97-101
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  • RESULTS: The primary tumor origin was mostly stomach (73 cases) and colon (61 cases).
  • Krukenberg tumor (pathologically proven signet ring cell carcinoma) was found in 34 cases: stomach (25), colon (2), appendix (1), and unknown (6).
  • The overall 5-year survival was 7.2% and the median survival time was 15 months.
  • The median survival times according to the primary tumor site showed significant differences (p=0.002) and were as follows: stomach 12 months, colon 17 months.
  • The median survival in cases with residual disease <2 cm vs. >2 cm was 26 months vs. 15 months (p=0.017) and the median survival with vs. without adjuvant chemotherapy was 16 months vs. 10 months (p=0.001).
  • However, age, bilateral tumors, chronology of diagnosis and mass size did not affect survival.
  • CONCLUSION: Cytoreductive surgery and post-operative adjuvant chemotherapy had a beneficial effect on survival in selected patients.
  • [MeSH-major] Colonic Neoplasms / pathology. Krukenberg Tumor / secondary. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Ovary / surgery. Stomach Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Prognosis. Proportional Hazards Models. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20018420.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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30. Xavier MH, Vergueiro Tde R, Vilar EG, Pinto JM, Issa MC, Pereira GB, Carocha AP: Cutaneous metastasis of gastric adenocarcinoma: an exuberant and unusual clinical presentation. Dermatol Online J; 2008;14(11):8
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  • [Title] Cutaneous metastasis of gastric adenocarcinoma: an exuberant and unusual clinical presentation.
  • There are different types of skin changes associated with internal malignancy.
  • One type is the skin involvement as a result of cutaneous metastasis from an internal tumor.
  • We report an exuberant and rare case of cutaneous metastasis from gastric adenocarcinoma as the first sign of this serious visceral cancer.
  • [MeSH-major] Carcinoma, Signet Ring Cell / secondary. Skin Neoplasms / secondary. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cachexia / etiology. Etoposide / administration & dosage. Fluorouracil / administration & dosage. Humans. Leucovorin / administration & dosage. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Middle Aged. Spinal Neoplasms / drug therapy. Spinal Neoplasms / secondary. Treatment Failure

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  • (PMID = 19094846.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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31. Akagi I, Miyashita M, Hashimoto M, Makino H, Nomura T, Ohkawa K, Tsuchiya Y, Tajiri T: Cardiac tamponade due to metastasis from early gastric cancer. Clin J Gastroenterol; 2008 Oct;1(3):100-104

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  • [Title] Cardiac tamponade due to metastasis from early gastric cancer.
  • We report a case of cardiac tamponade caused by metastasis from early gastric cancer.
  • A 44-year-old woman was detected to have an abnormality of the stomach on barium meal during an annual medical checkup.
  • Gastroendoscopy disclosed superficial depressed gastric lesions, and histopathological examination of biopsy specimens revealed the diagnosis of poorly differentiated adenocarcinoma and signet-ring cell carcinoma.
  • Computed tomography (CT) and ultrasonography (US) revealed no evidence of metastasis.
  • We performed distal gastrectomy with regional lymph node dissection.
  • Histopathological examination revealed poorly differentiated adenocarcinoma and signet-ring cell carcinoma confined to the mucosal layer.
  • Adjuvant chemotherapy was administered on an outpatient basis with 36 courses of mitomycinC infused (8 mg/day) once every 4 weeks.
  • However, 3 years after the surgery, the patient developed cardiac tamponade due to carcinomatous pericarditis.
  • We performed drainage of the malignant effusion and initiated treatment with S-1 and docetaxel.

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  • (PMID = 26193646.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Cardiac tamponade / Early gastric cancer / Metastasis / Pericardial effusion
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32. Putman S: Cases from the Osler Medical Service at Johns Hopkins University. Am J Med; 2002 May;112(7):575-6
Hazardous Substances Data Bank. HEPARIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 73-year-old man who had been receiving chronic anticoagulation treatment with warfarin for multiple prior strokes presented to the hospital because of several weeks of pain in his right calf.
  • The morning after admission, he developed an acutely swollen, painful upper extremity and was found to have an occlusive clot in the left subclavian vein.
  • Because these thrombi occurred in the setting of a therapeutic prothrombin time (international normalized ratio, 2.7) on warfarin, he was begun on treatment with intravenous heparin.
  • What is the diagnosis?
  • [MeSH-major] Carcinoma, Signet Ring Cell / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Fatal Outcome. Heparin / therapeutic use. Humans. Male. Neoplasm Metastasis. Thrombosis / drug therapy. Thrombosis / etiology. Tomography, X-Ray Computed

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  • (PMID = 12015251.001).
  • [ISSN] 0002-9343
  • [Journal-full-title] The American journal of medicine
  • [ISO-abbreviation] Am. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9005-49-6 / Heparin
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33. Lee JL, Kang YK, Kim TW, Chang HM, Lee GW, Ryu MH, Kim E, Oh SJ, Lee JH, Kim SB, Kim SW, Suh C, Lee KH, Lee JS, Kim WK, Kim SH: Leptomeningeal carcinomatosis in gastric cancer. J Neurooncol; 2004 Jan;66(1-2):167-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leptomeningeal carcinomatosis in gastric cancer.
  • LMC was the initial manifestation of gastric cancer in 2 patients.
  • With the exception of 1 patient, the primary gastric cancer was Borrmann type III or IV, and 88% had poorly differentiated or signet-ring cell histology.
  • The gastric cancer was progressive or a recurrent disease in most of the patients.
  • Computed tomography (CT) findings were abnormal in a minor proportion of the patients, while magnetic resonance imaging (MRI) revealed abnormality in 67% of the patients, which could help the diagnosis.
  • LMC complicating gastric cancer was ultimately fatal.
  • By univariate analysis, good performance status, intrathecal chemotherapy, and low CSF LDH concentration favored survival.
  • Multivariate analysis revealed that the administration of CSF chemotherapy was the independent prognostic factor for survival.
  • [MeSH-major] Carcinoma / pathology. Meningeal Neoplasms / pathology. Neoplasms, Second Primary / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Cranial Nerve Neoplasms / pathology. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local. Nervous System Diseases / etiology. Retrospective Studies. Survival Analysis. Tomography, X-Ray Computed

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34. Baba Y, Ishikawa S, Ikeda K, Honda S, Miyanari N, Iyama K, Baba H: A patient with 43 synchronous early gastric carcinomas with a Krukenberg tumor and pericardial metastasis. Gastric Cancer; 2007;10(2):135-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A patient with 43 synchronous early gastric carcinomas with a Krukenberg tumor and pericardial metastasis.
  • Gastroendoscopy disclosed 16 superficial depressed gastric lesions, and the histopathological diagnosis of the biopsy specimens was poorly differentiated adenocarcinoma and signet-ring cell carcinoma.
  • Computed tomography (CT), ultrasonography (US), and positron emission tomography (PET) examinations revealed no other metastasis except for that observed in the ovaries.
  • A postoperative histological examination revealed 43 isolated gastric lesions which were scattered over the entire resected stomach; they were all confined to the mucosa.
  • Cancer cell invasion in the lymphatics was detected only in the submucosal region beneath the main tumor.
  • Both ovarian tumors were diagnosed as metastasis of signet-ring cell carcinoma (Krukenberg tumor).
  • Adjuvant chemotherapy with irinotecan (CPT-11) and low-dose cisplatin (CDDP) was given on an outpatient basis, but 1 year after the surgery, carcinomatous pericarditis occurred.
  • [MeSH-major] Adenocarcinoma / secondary. Heart Neoplasms / secondary. Krukenberg Tumor / secondary. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / secondary. Pericardium / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Cardiac Tamponade / etiology. Cardiac Tamponade / surgery. Fatal Outcome. Female. Gastrectomy. Humans. Lymphatic Metastasis / pathology. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17577625.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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