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1. Milingos D, Doumplis D, Savage P, Seckl M, Lindsay I, Smith JR: Placental site trophoblastic tumor with an ovarian metastasis. Int J Gynecol Cancer; 2007 Jul-Aug;17(4):925-7
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  • [Title] Placental site trophoblastic tumor with an ovarian metastasis.
  • Placental site trophoblastic tumors (PSTT) are the rarest form of gestational trophoblastic disease (GTD).
  • The most common metastatic sites are the lung, liver, and vagina while spread to the adnexa is relatively unusual.
  • We describe a case of a 35-year-old woman presenting with PSTT and ovarian metastasis who was successfully treated with radical hysterectomy, bilateral oophorectomy, pelvic lymph node dissection, and postoperative chemotherapy.
  • The case highlights the possibility of ovarian metastases despite normal preoperative imaging and confirms the value of multidisciplinary management of this rare illness.
  • [MeSH-major] Ovarian Neoplasms / secondary. Trophoblastic Tumor, Placental Site / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Neoplasm Metastasis. Pregnancy

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  • (PMID = 17343608.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Sotiropoulos GC, Kaiser GM, Lang H, Treckmann J, Brokalaki EI, Pottgen C, Gerken G, Paul A, Broelsch CE: Staging laparoscopy in gastric cancer. Eur J Med Res; 2005 Feb 28;10(2):88-91
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  • [Title] Staging laparoscopy in gastric cancer.
  • BACKGROUND: As patients with gastric cancer are offered choices between surgical resection, neoadjuvant or palliative chemotherapy, or symptomatic relief alone, the need for accurate preoperative staging becomes apparent.
  • METHODOLOGY: Staging laparoscopy was performed in 45 patients with potentially resectable gastric cancer as determined by physical examination, gastroscopy, endosonography, transcutaneous ultrasonography and current generation computed tomography.
  • Conventional clinic staging and laparoscopic staging according to the Tumor-Node-Metastases classification of the International Union against Cancer were registered separately on a database.
  • In 10 patients of them peritoneal seeding was first found during laparoscopy, whereas additional liver metastases were detected in 3 patients and Krukenberg's tumor in one.
  • As a consequence, the therapy planning was changed and laparotomy was avoided in 14 of these patients as the first operative procedure.
  • Sensitivity of clinical staging was especially poor for stage IV tumors (5.3%) and for the majority of stage IIIB tumors (42.9%).
  • CONCLUSIONS: The value of laparoscopy in staging patients with gastric carcinoma could be demonstrated in this study.
  • It is a safe and effective staging modality, helping to avoid unnecessary laparotomies and providing new means of directing appropriate treatment strategy.
  • [MeSH-major] Gastroscopy. Liver Neoplasms / pathology. Lymphatic Metastasis / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed. Ultrasonography, Interventional

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  • (PMID = 15817429.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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3. McCormick CC, Giuntoli RL 2nd, Gardner GJ, Schulick RD, Judson K, Ronnett BM, Vang R, Bristow RE: The role of cytoreductive surgery for colon cancer metastatic to the ovary. Gynecol Oncol; 2007 Jun;105(3):791-5
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  • [Title] The role of cytoreductive surgery for colon cancer metastatic to the ovary.
  • OBJECTIVE: We sought to further elucidate the survival impact of cytoreductive surgery among patients with colon cancer metastatic to the ovary.
  • METHODS: All women diagnosed with primary colon cancer metastatic to the ovary at a single institution from 1980 to 2005 were retrospectively identified.
  • RESULTS: A total of 39 patients with 40 cases of colon cancer metastatic to the ovary were identified.
  • Patients with metastatic disease confined to the ovaries (n=11) had a median overall survival (OS) time of 61 months (range 15-120) compared to 17 months (range 0.5-73) for those with more extensive metastases (n=24) (p=0.0428).
  • All major complications occurred in women with diffuse disease who underwent extensive cytoreductive surgery.
  • CONCLUSIONS: The observation that optimal cytoreduction was associated with prolonged PFS and OS in both patients with localized ovarian and widespread metastases of colon cancer suggests a role for surgical management of metastatic colon cancer in women.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Humans. Middle Aged. Neoplasms, Multiple Primary / drug therapy. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Neoplasms, Second Primary / drug therapy. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / surgery. Retrospective Studies. Survival Rate

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  • (PMID = 17408727.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Kim WY, Kim TJ, Kim SE, Lee JW, Lee JH, Kim BG, Bae DS: The role of cytoreductive surgery for non-genital tract metastatic tumors to the ovaries. Eur J Obstet Gynecol Reprod Biol; 2010 Mar;149(1):97-101
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  • [Title] The role of cytoreductive surgery for non-genital tract metastatic tumors to the ovaries.
  • STUDY DESIGN: From September 1994 to December 2006, 158 patients with pathologically confirmed metastatic tumors to the ovaries at Samsung Medical Center (SMC) were included in this study.
  • RESULTS: The primary tumor origin was mostly stomach (73 cases) and colon (61 cases).
  • Krukenberg tumor (pathologically proven signet ring cell carcinoma) was found in 34 cases: stomach (25), colon (2), appendix (1), and unknown (6).
  • Residual disease after surgery was >2 cm in 65 (41.1%) cases and <2 cm in 93 (58.9%) cases.
  • The overall 5-year survival was 7.2% and the median survival time was 15 months.
  • The median survival times according to the primary tumor site showed significant differences (p=0.002) and were as follows: stomach 12 months, colon 17 months.
  • The median survival in cases with residual disease <2 cm vs. >2 cm was 26 months vs. 15 months (p=0.017) and the median survival with vs. without adjuvant chemotherapy was 16 months vs. 10 months (p=0.001).
  • However, age, bilateral tumors, chronology of diagnosis and mass size did not affect survival.
  • CONCLUSION: Cytoreductive surgery and post-operative adjuvant chemotherapy had a beneficial effect on survival in selected patients.
  • [MeSH-major] Colonic Neoplasms / pathology. Krukenberg Tumor / secondary. Neoplasms, Second Primary / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Ovary / surgery. Stomach Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Prognosis. Proportional Hazards Models. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20018420.001).
  • [ISSN] 1872-7654
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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5. Takagi T, Nakase Y, Fukumoto K, Miyagaki T, Yamakawa N, Taniike K, Kobayashi Y, Kanemitsu D, Kassai K, Sakamoto K, Takenaka S, Itani K: [A patient with metachronous ovarian metastases of signet-ring cell carcinoma of the transverse colon showing long-term survival after surgery]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2260-2
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  • [Title] [A patient with metachronous ovarian metastases of signet-ring cell carcinoma of the transverse colon showing long-term survival after surgery].
  • She was referred to our hospital for close evaluation and treatment.
  • Since circumferential cancer was detected in the transverse colon by lower digestive tract endoscopy, the patient was hospitalized for surgical treatment.
  • Transverse colectomy (Cur A) was performed, histopathological examination indicated signet-ring cell carcinoma of the transverse colon, and the lesion was diagnosed as type 4, SS, ly3, v0, n1 (+), Stage III a.
  • Postoperative adjuvant chemotherapy was recommended, but the patient was psychologically unstable and strongly rejected chemotherapy.
  • The patient was periodically followed-up after surgery, but a mass was detected in the left ovary by CT after 1 year and 6 months, and bilateral ovariectomy was performed with a diagnosis of ovarian metastasis.
  • The histopathological diagnosis was signet-ring cell carcinoma, and the ovarian lesions were judged to be metastases of the transverse colon carcinoma.
  • Since the patient did not consent to postoperative chemotherapy, as after the initial surgery, she was followed-up without treatment.
  • She was admitted with ileus due to peritoneal metastasis 4 years and 10 months after the initial surgery, and, despite of the surgery, she died due to carcinoma 5 years after the initial surgery.
  • [MeSH-major] Carcinoma, Signet Ring Cell / pathology. Carcinoma, Signet Ring Cell / secondary. Colon, Transverse. Colonic Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / secondary. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery

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  • (PMID = 20037389.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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6. Sakakura C, Hagiwara A, Yoshikawa T, Hamada T, Yamagishi H: Huge ovarian metastasis from jejunal cancer occurring immediately after initial operation. Hepatogastroenterology; 2005 Mar-Apr;52(62):425-8
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  • [Title] Huge ovarian metastasis from jejunal cancer occurring immediately after initial operation.
  • Correct preoperative diagnosis of jejunal cancer is difficult, and there are no clear guidelines for the postoperative follow-up to monitor the recurrence of jejunal cancer.
  • This report describes asynchronous ovarian metastasis from jejunal cancer occurring after initial operation.
  • The patient was a 68-year-old postmenopausal woman with a preoperatively correctly diagnosed jejunal cancer.
  • Three months later, vaginal bleeding and a large metastasis in the left ovary were detected, for which a left oophorectomy was performed.
  • Peritoneal dissemination was also detected perioperatively, so that chemotherapy with 5-FU/leukovoline was started.
  • Our case demonstrates that it is necessary to pay careful attention to synchronous or non-synchronous metastases to the ovaries after operation for jejunal cancer in females.
  • Consideration should also be given to the efficacy of oophorectomy for ovarian metastases and of intensive chemotherapy combined with jejunal resection for carcinoma because of the poor prognosis of these treatment modalities.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery. Ovarian Neoplasms / secondary
  • [MeSH-minor] Angiography. Chemotherapy, Adjuvant. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Ovariectomy. Peritoneum / pathology. Postoperative Period. Radiography, Abdominal. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 15816449.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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7. Gupta D, Deavers MT, Silva EG, Malpica A: Malignant melanoma involving the ovary: a clinicopathologic and immunohistochemical study of 23 cases. Am J Surg Pathol; 2004 Jun;28(6):771-80
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  • [Title] Malignant melanoma involving the ovary: a clinicopathologic and immunohistochemical study of 23 cases.
  • Ovarian malignant melanoma (MM), primary or metastatic, is an extremely rare tumor and in the absence of a previous diagnosis can represent a diagnostic challenge.
  • A previous history of MM was definitively obtained in 14 patients; in these cases, the interval between the primary MM and the ovarian metastasis ranged from 15 to 228 months (mean 77.7 months).
  • The tumor was unilateral in 19 and bilateral in 4 cases.
  • The tumor size ranged from 4.5 to 23 cm (average 10 cm); the melanoma arising in a cystic teratoma was 0.2 mm in thickness.
  • The tumor was grossly pigmented in 8 cases (35%).
  • The tumor cell type was epithelioid in 19 cases, spindled in 2 cases, mixed epithelioid and spindled in 1 case, and small cell in 1 case.
  • In 8 cases, initial diagnoses included sex cord stromal tumor, germ cell tumor, sarcoma, or undifferentiated carcinoma.
  • Treatment performed in 18 of the cases are as follows: oophorectomy with/without chemotherapy (10); total abdominal hysterectomy with bilateral salpingo-oophorectomy with/without chemotherapy (6); vaginal hysterectomy, bilateral salpingo-oophorectomy, and chemotherapy (1); and total abdominal hysterectomy with salpingo-oophorectomy (1).
  • Thirteen patients died of disease (range 2-76 months), 3 are alive with disease (6-18 months), and 2 have no evidence of disease at 24 and 96 months; one was the patient with melanoma arising within a teratoma.
  • In conclusion, MM involving the ovary is a rare disease, predominantly seen in women of reproductive age, and is associated with a poor prognosis.
  • The tumor is most often metastatic from another site and is unilateral in most cases.
  • Nodular or diffuse pattern and epithelioid cell type are most frequently seen, and the tumor can be mistaken for germ cell and sex cord stromal tumors.
  • [MeSH-major] Melanoma / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm. Calbindin 2. DNA-Binding Proteins / analysis. Ethnic Groups. Female. Humans. Hysterectomy. Immunohistochemistry. Inhibins / analysis. MART-1 Antigen. Melanoma-Specific Antigens. Microphthalmia-Associated Transcription Factor. Middle Aged. Monophenol Monooxygenase / analysis. Neoplasm Metastasis. Neoplasm Proteins / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Teratoma / pathology. Transcription Factors / analysis. Treatment Outcome

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  • (PMID = 15166669.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / DNA-Binding Proteins; 0 / MART-1 Antigen; 0 / MITF protein, human; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Microphthalmia-Associated Transcription Factor; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Transcription Factors; 57285-09-3 / Inhibins; EC 1.14.18.1 / Monophenol Monooxygenase
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8. Falchook GS, Wolff RA, Varadhachary GR: Clinicopathologic features and treatment strategies for patients with pancreatic adenocarcinoma and ovarian metastases. Gynecol Oncol; 2008 Mar;108(3):515-9
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  • [Title] Clinicopathologic features and treatment strategies for patients with pancreatic adenocarcinoma and ovarian metastases.
  • BACKGROUND: Ovarian metastases from pancreatic adenocarcinoma are uncommon and data on the clinical features, treatment, and survival of patients with pancreatic adenocarcinoma with ovarian metastases is limited.
  • The purpose of this study is to define the clinical characteristics and treatment strategies for this patient population.
  • METHODS: We reviewed the charts of 18 patients with pancreatic adenocarcinoma with ovarian metastasis who had presented to The University of Texas M. D.
  • Anderson Cancer Center from 1985 to 2005.
  • RESULTS: Of the 18 patients diagnosed with pancreatic adenocarcinoma and ovarian metastases, 8 (44%) presented with ovarian metastases initially and a pancreatic primary tumor became apparent only on further imaging or during surgery.
  • On pathology review, the primary pancreatic cancers (5 out of 18) and ovarian metastases (8 out of 16) showed mucinous characteristics.
  • Patients who underwent resection of their ovarian metastases followed by chemotherapy had a trend of longer median survival compared to patients who received chemotherapy alone without resection of the ovarian metastases (16.5 vs. 8.5 months, respectively; p=0.28).
  • Patients who responded to chemotherapy had a trend of longer survival compared to nonresponders (19 vs. 6 months, respectively; p=0.1).
  • No responses were observed in the ovarian metastases to chemotherapy alone.
  • CONCLUSIONS: Primary pancreatic adenocarcinoma with synchronous ovarian metastases may present initially as symptomatic ovarian masses and they commonly have mucinous histologic characteristics.
  • Surgical resection of ovarian metastases may play an important palliative role in the treatment of symptomatic patients with good performance status and lead to longer survival.
  • [MeSH-major] Adenocarcinoma / therapy. Ovarian Neoplasms / therapy. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Databases, Factual. Female. Humans. Medical Records. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Survival Analysis. Texas. Treatment Outcome

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  • (PMID = 18164378.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Terek MC, Ozkinay E, Zekioglu O, Erhan Y, Cagirgan S, Pehlivan M, Mgoyi L: Acute leukemia in pregnancy with ovarian metastasis: a case report and review of the literature. Int J Gynecol Cancer; 2003 Nov-Dec;13(6):904-8
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  • [Title] Acute leukemia in pregnancy with ovarian metastasis: a case report and review of the literature.
  • Bone marrow biopsy revealed acute lymphocytic leukemia, French American-British L2 subtype B cell immunotype.
  • A left ovarian mass was identified during the cesarean section which later proved to be lymphoblastic infiltration.
  • The patient was started on induction chemotherapy consisting of vincristine, daunorubicin, prednisolone, and l-asparaginase immediately after the diagnosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Ovarian Neoplasms / secondary. Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Pregnancy Complications, Neoplastic / drug therapy. Pregnancy Complications, Neoplastic / pathology

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  • (PMID = 14675333.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 9PHQ9Y1OLM / Prednisolone; EC 3.5.1.1 / Asparaginase; ZS7284E0ZP / Daunorubicin
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10. Neverauskiene S, Machtejeviene E, Vaitkiene D, Juodzbaliene EB: [Disseminated ovarian, bone, and bone marrow metastases from gastric cancer]. Medicina (Kaunas); 2006;42(11):923-31
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  • [Title] [Disseminated ovarian, bone, and bone marrow metastases from gastric cancer].
  • The main cause of death in patients with gastric cancer is disease dissemination.
  • It is not clear why gastric cancer metastasizes to different organs.
  • Early detection and destruction of circulating malignant cells before developing metastases may markedly improve survival of these patients.
  • Krukenberg tumors (metastases of non-gynecological origin in the ovaries) usually are circular cell carcinomas of gastric cancer.
  • Bone metastases of gastric cancer are rare, but if they are diagnosed, patients survive only 2-5 months on the average.
  • Disseminated bone marrow metastases from gastric cancer do not always show the sudden course of the disease, but hematological complications are signs of poor prognosis.
  • Currently, chemotherapy is the most effective treatment for outspread gastric cancer.
  • Unfortunately, there is no exclusively effective scheme for treatment.
  • Lymph node metastases are more sensitive to chemotherapy than primary gastric cancer, while in contrary, hepatic metastases are less sensitive than primary gastric cancer.
  • This article includes a literature review and a rare case of gastric cancer.
  • [MeSH-major] Bone Marrow Neoplasms / secondary. Bone Neoplasms / secondary. Carcinoma / secondary. Ovarian Neoplasms / secondary. Paraneoplastic Syndromes. Stomach Neoplasms
  • [MeSH-minor] Biopsy. Female. Humans. Lymphatic Metastasis. Middle Aged. Prognosis. Stomach / pathology. Time Factors


11. Bloch-Marcotte C, Ambrosetti D, Novellas S, Caramella T, Dahman M, Thyss A, Chevallier P: Ovarian metastasis from choroidal melanoma. Clin Imaging; 2008 Jul-Aug;32(4):318-20
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  • [Title] Ovarian metastasis from choroidal melanoma.
  • Ocular melanoma has a strong tendency to metastasize often several years after its initial diagnosis was made.
  • We report on the case of a 50-year-old woman who was treated 20 years earlier for an ocular melanoma and currently seen regularly in our institute for liver metastases that were treated by chemotherapy.
  • After three treatments, a check-up with computed tomography demonstrated the presence of a right ovarian mass.
  • An ovariectomy was performed, and the pathological examination confirmed the diagnosis of an ovarian metastasis from an ocular melanoma.
  • This is the fourth case of metastasis to the ovary from an ocular melanoma reported in the medical literature.
  • [MeSH-major] Choroid Neoplasms / pathology. Melanoma / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Female. Humans. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Middle Aged

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  • (PMID = 18603189.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Zehetleitner G, Thiel I, Petru E: Long-term disease-free survival after breast cancer metastatic to the ovary. Int J Gynecol Cancer; 2002 May-Jun;12(3):317-8
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  • [Title] Long-term disease-free survival after breast cancer metastatic to the ovary.
  • The prognosis of patients with breast cancer symptomatically metastatic to the ovary is almost uniformly poor.
  • In this case report, we present a 33-year-old para-4 with a symptomatic metastasis to the ovary.
  • Previously, a modified radical mastectomy with adjuvant radiotherapy had been performed for invasive ductal carcinoma of the left breast.
  • Laparotomy showed a 13-cm tumor of the left ovary; frozen section histology showed malignancy consistent with the previous breast cancer.
  • The patient received adjuvant combination chemotherapy.
  • About 5 years later, a carcinoma of the right breast was treated with conservative surgery and adjuvant radiation and chemotherapy.
  • At the last follow-up, more than 13 years after the first breast cancer and 12 years after the ovarian metastasis, the patient was alive and well without evidence of disease.
  • Bilateral oophorectomy is a therapeutic option in premenopausal patients with localized or advanced breast cancer.
  • Our patient experienced long-term disease-free survival following an isolated metastasis to one ovary.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Disease-Free Survival. Female. Humans. Laparotomy. Mastectomy, Radical. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 12060456.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Katase K, Shimizu Y, Kobayashi Y, Hasumi K: [Chemotherapy with combination of UFT and cisplatin against metastatic ovarian tumor originating from gastric cancer]. Gan To Kagaku Ryoho; 2004 Jun;31(6):943-7
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  • [Title] [Chemotherapy with combination of UFT and cisplatin against metastatic ovarian tumor originating from gastric cancer].
  • Krukenberg's tumor, an metastatic ovarian tumor originating from gastric cancer, is a disease with extremely poor prognosis, and it is rare for patients to survive for more than 2 years after the diagnosis.
  • We encountered a patient in whom a long-term good prognosis could be obtained probably because of the effects of chemotherapy after the ovarian tumor extraction.
  • Enhancement of the antitumor effects by the concomitant use of 5-FU and cisplatin has been attracting attention, and the methods of administration of these drugs have been investigated by numerous researchers as FP therapy.
  • It was characteristic to the treatment of our patient that 5-FU was administered in the form of oral UFT.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Administration, Oral. Adult. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Routes. Female. Humans. Hysterotomy. Ovariectomy. Prognosis. Tegafur / administration & dosage. Uracil / administration & dosage


14. Maekawa H, Sato K, Komatsu Y, Orita H, Sakurada M: Jejunal cancer detected after a resection of bilateral ovarian metastasis: report of a case. Surg Today; 2010 Nov;40(11):1084-7
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  • [Title] Jejunal cancer detected after a resection of bilateral ovarian metastasis: report of a case.
  • Computed tomography and magnetic resonance imaging showed bilateral ovarian tumors.
  • Although these ovarian tumors were suspected of being metastatic, the primary tumor site could not be detected before the bilateral salpingo-oophorectomy.
  • At the time of laparotomy, there was no apparent peritoneal dissemination or ascites.
  • The pathological findings suggested that the ovarian tumors were metastases from cancer of the digestive tract.
  • Positron emission tomography using (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) and double-balloon enteroscopy detected jejunal cancer.
  • A second laparotomy for the resection of jejunal cancer was performed.
  • The patient received adjuvant chemotherapy, and there has not been any recurrence for 24 months since the resection was performed.
  • In conclusion, FDG-PET was found to play a valuable role in the detection of the primary tumor.
  • Intensive chemotherapy and surgical treatment also contributed to the long-term survival of the patient.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Jejunal Neoplasms / diagnosis. Ovarian Neoplasms / secondary
  • [MeSH-minor] Chemotherapy, Adjuvant. Double-Balloon Enteroscopy. Female. Fluorodeoxyglucose F18. Humans. Laparotomy. Magnetic Resonance Imaging. Middle Aged. Positron-Emission Tomography. Prognosis. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • [Cites] Hepatogastroenterology. 2005 Mar-Apr;52(62):425-8 [15816449.001]
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  • (PMID = 21046510.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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15. Imamura H, Kishimoto T, Kawabata R, Furukawa H, Fukunaga M, Ohzato H, Miyanishi K, Yamamoto T, Miwa H: [A case of gastric cancer with bilateral ovarian metastasis after gastrectomy performed ovarian resection]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2490-2
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  • [Title] [A case of gastric cancer with bilateral ovarian metastasis after gastrectomy performed ovarian resection].
  • The patient was a 51-year-old female, who underwent radical surgery for cancer of remnant stomach in May 2006 (f-T4N0M0P0H0CY0, por 2, Stage IIIA, Cur B).
  • Bilateral ovarian resection was performed in March 2009 for bilateral ovarian metastasis, so called "Krukenberg tumor" with peritoneal dissemination detected with CT scan after one-year adjuvant chemotherapy with S-1 (80 mg/m2, 4 weeks on and 2 weeks off).
  • As of June 2010, she is alive and maintain her status quo after 6 courses of S-1 plus CDDP combination therapy (S-1 80 mg/m2, 3 weeks on, CDDP 60 mg/m2, started at day 8, ended 35 days later) followed by S-1 for residual peritoneal dissemination detected at operation.
  • In ovary metastasis of gastric cancer, even if accompanied by peritoneum metastasis, ovarian resection as a reduction surgery followed by chemotherapy may improve survival.
  • [MeSH-major] Krukenberg Tumor / secondary. Krukenberg Tumor / therapy. Ovarian Neoplasms / secondary. Ovarian Neoplasms / therapy. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery
  • [MeSH-minor] Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Combinations. Female. Gastrectomy. Humans. Middle Aged. Ovariectomy. Oxonic Acid / administration & dosage. Tegafur / administration & dosage

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  • (PMID = 21224616.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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16. Zhang MQ, Chen MZ: [Analysis of 174 cases with cervical cancer in women under 35 years old]. Zhonghua Fu Chan Ke Za Zhi; 2003 Nov;38(11):689-93
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  • [Title] [Analysis of 174 cases with cervical cancer in women under 35 years old].
  • OBJECTIVE: To analyse the prevalence, etiology, presentation, preserving ovary and prognosis of cervical cancer in women under 35 years old.
  • RESULTS: The percentage of new cervical cancer cases from 1991 to 2001 was 1.2%, 1.2%, 4.3%, 4.2%, 4.6%, 4.5%, 7.3%, 9.0%, 10.7%, 9.4%, 10.8%, respectively (P < 0.01).
  • The number of cases with carcinoma in situ, stage I, stage II, stage III was 22, 40, 94, 18, respectively.
  • The ovarian metastasis was 0.8%.
  • COX regression analysis indicated that stage, lymph-vascular involvement and the depth of tumor infiltration were independently prognostic factors.
  • For patients with one risk factor after radical surgery, the survival of patients with adjuvant radiation therapy and chemotherapy or not was 100%, 88%, respectively (P > 0.05).
  • CONCLUSIONS: There is an increasing prevalence of cervical cancer in women under 35 years old, which is possibly related to the sexual transition.
  • The preserving ovary in young cervical cancer patients is safe and effective.
  • Adjuvant treatment may be helpful for patients with 2 or more risk factors after radical surgery.
  • [MeSH-major] Uterine Cervical Neoplasms / therapy


17. Takenoue T, Yamada Y, Miyagawa S, Akiyama Y, Nagawa H: Krukenberg tumor from gastric mucosal carcinoma without lymphatic or venous invasion: report of a case. Hepatogastroenterology; 2001 Jul-Aug;48(40):1211-4
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  • [Title] Krukenberg tumor from gastric mucosal carcinoma without lymphatic or venous invasion: report of a case.
  • A 49-year-old woman was admitted because of early gastric carcinoma.
  • In the resected specimen, gastric mucosal carcinoma without lymph node metastases was located in the prepyloric region.
  • Histologic type was moderately differentiated adenocarcinoma and signetring cell carcinoma, and there was no lymphatic or venous invasion.
  • One year after operation, a left ovarian tumor was detected.
  • Pathological findings revealed Krukenberg tumors originating from the gastric carcinoma in the bilateral ovaries.
  • One year after the second operation, a hard mass due to cancer recurrence developed in the pelvis with symptoms including tenesmus and abdominal pain.
  • Chemotherapy and palliative colostomy were performed.
  • We experienced a rare case of Krukenberg tumor with two interesting points; its origin was gastric mucosal carcinoma without lymphatic or venous invasion, and the patient survived for more than four years after the diagnosis.
  • [MeSH-major] Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Female. Gastrectomy. Humans. Middle Aged. Tomography, X-Ray Computed


18. Ebisui C, Ohkubo K, Akitake H, Ohtsuka M, Maekawa T, Yoshioka S, Hama N, Kashiwazaki M, Taniguchi M, Tsujie M, Konishi M, Fujimoto T: [A case of ovarian metastasis from colon cancer successfully treated with multidisciplinary therapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2542-4
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  • [Title] [A case of ovarian metastasis from colon cancer successfully treated with multidisciplinary therapy].
  • An 80-year-old female patient was undergone sigmoidectomy with D2 lymph node dissection for type 2 sigmoid colon cancer in February 2007.
  • A post operative pathological finding of cancer was SS, N0, P0, H0, M0 (Stage II), curative A.
  • CT scan and MRI revealed a mass of 10 cm in diameter with multiple cysts in the pelvic cavity, which was diagnosed a malignant ovarian tumor.
  • In May 2008, total hysterectomy, bilateral oophorectomy, and partial omentectomy were performed and its pathological finding was metastatic ovarian tumor originating from colon cancer.
  • Adjuvant chemotherapy was administered, as cancer cells were detected in the ascites.
  • [MeSH-major] Adenocarcinoma / pathology. Krukenberg Tumor / secondary. Krukenberg Tumor / therapy. Ovarian Neoplasms / secondary. Ovarian Neoplasms / therapy. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Drug Combinations. Female. Humans. Hysterectomy. Ovariectomy. Oxonic Acid / administration & dosage. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 21224633.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 5VT6420TIG / Oxonic Acid; 1-UFT protocol
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19. Yang TS, Hsu KC, Tang R, Chang TC: Colon carcinoma with synchronous ovarian metastasis--report and discussion of five cases. Anticancer Drugs; 2000 Apr;11(4):279-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colon carcinoma with synchronous ovarian metastasis--report and discussion of five cases.
  • Ovarian metastasis may present at the time of initial diagnosis of colon carcinoma or as a later recurrence.
  • Little meaningful information is available regarding the treatment and outcome of synchronous ovarian metastasis of colon carcinoma.
  • This report describes the clinical course of five patients with synchronous ovarian metastasis of colon carcinoma who were treated with aggressive surgery and chemotherapy.
  • The treatment consisted of maximal surgical debulking followed by systemic chemotherapy with weekly 24 h infusion of high-dose 5-fluorouracil and leucovorin.
  • All of the five patients had subsequent disease-free periods ranging from 6 to 43+ months following operation.
  • Two of the patients who had no or minimal peritoneal involvement were still alive without disease at 33 and 43 months.
  • The data from these cases suggest that aggressive surgery and systemic chemotherapy may be highly efficacious in the treatment of colon carcinoma with synchronous ovarian metastasis.
  • Maximal debulking followed by chemotherapy may be particularly effective in those patients with minimal peritoneal involvement.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Signet Ring Cell / secondary. Colonic Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Humans. Leucovorin / administration & dosage. Middle Aged

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  • (PMID = 10898544.001).
  • [ISSN] 0959-4973
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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20. Busto Martín LA, Janeiro Pais M, González Dacal J, Chantada Abal V, Busto Castañón L: Signet-ring cell adenocarcinoma of the bladder: case series between 1990-2009. Arch Esp Urol; 2010 Mar;63(2):150-3
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  • [Title] Signet-ring cell adenocarcinoma of the bladder: case series between 1990-2009.
  • OBJECTIVES: To present a revision on the signet-ring cell bladder adenocarcinomas found in our department.
  • METHODS/RESULTS: We reviewed all the transurethral resections of the bladder (TURB) performed between 1990 and 2009 finding 9 cases of primary signet ring cell adenocarcinomas (4 pure and 5 mixed).
  • Definitive treatment was radical cystectomy with Bricker's urinary diversion in four patients, cysctectomy with Mainz's II diversion in one patient and palliative management with TURB in three cases and percutaneous nephrostomy in the remaining case.
  • We used adyuvant chemotherapy in three cases.
  • Only two patients were alive at the time of the study.
  • Mean survival was 327 days for pure tumors and 586 for the mixed ones.
  • CONCLUSIONS: Signet-ring cell primary adenocarcinoma of the bladder is an uncommon type of tumor, with worse prognosis than transitional cell cancer.
  • It is important to discard other possible metastatic origins(like stomach, prostate, lung, or ovary) because the management will be different.
  • Radical cystectomy is the treatment of choice, with adyuvant chemotherapy if possible.
  • [MeSH-major] Carcinoma, Signet Ring Cell. Urinary Bladder Neoplasms

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  • (PMID = 20378938.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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21. Cosme A, Ojeda E, Bujanda L, Torrado J, Barrio J: [Krukenberg tumor secondary to gastric carcinoma in a woman in her eighth month of pregnancy]. Gastroenterol Hepatol; 2001 Feb;24(2):63-5
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  • [Title] [Krukenberg tumor secondary to gastric carcinoma in a woman in her eighth month of pregnancy].
  • [Transliterated title] Tumor de Krukenberg secundario a carcinoma gástrico en una gestante de ocho meses.
  • The association of gastric cancer and pregnancy is rare.
  • Tumors tend to be in advanced stage when diagnosed since the symptoms of gastric cancer are easily presumed to be secondary to those of normal pregnancy.
  • We report the case of a 43-year-old female with gastric carcinoma presenting as a Krukenberg's tumor in the eighth month of gestation.
  • A healthy child was born and after delivery, partial gastrectomy was performed and adjuvant chemotherapy was administered.
  • The patient died 12 months after diagnosis.
  • [MeSH-major] Krukenberg Tumor. Ovarian Neoplasms. Pregnancy Complications, Neoplastic


22. Moshfeghi DM, Wilson MW, Haik BG, Hill DA, Rodriguez-Galindo C, Pratt CB: Retinoblastoma metastatic to the ovary in a patient with Waardenburg syndrome. Am J Ophthalmol; 2002 May;133(5):716-8
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  • [Title] Retinoblastoma metastatic to the ovary in a patient with Waardenburg syndrome.
  • PURPOSE: To report a child with retinoblastoma and Waardenburg syndrome who developed ovarian metastases.
  • The patient had a Reese-Ellsworth Group Va tumor and underwent enucleation.
  • Two years later, she developed metastatic disease involving the bone marrow, right humerus, both supraorbital bones, and both tibias.
  • She was treated with chemotherapy, orbital irradiation, and bone marrow transplant but returned 7 months later with back pain and urinary retention.
  • RESULTS: Exploratory laparotomy revealed a right ovarian mass, and the excised ovary showed metastatic retinoblastoma.
  • The child underwent chemotherapy and remained asymptomatic for 9 months, when brain metastases were diagnosed.
  • CONCLUSION: We believe that this is the first description of a patient with retinoblastoma and Waardenburg syndrome and of an ovarian metastasis from retinoblastoma.
  • [MeSH-major] Ovarian Neoplasms / secondary. Retinal Neoplasms / pathology. Retinoblastoma / secondary. Waardenburg Syndrome / pathology
  • [MeSH-minor] Bone Neoplasms / secondary. Brain Neoplasms / secondary. Child, Preschool. Eye Enucleation. Fatal Outcome. Female. Humans. Ovariectomy

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  • (PMID = 11992879.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30-CA21765; United States / NCI NIH HHS / CA / P30-CA23099
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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23. Baba Y, Ishikawa S, Ikeda K, Honda S, Miyanari N, Iyama K, Baba H: A patient with 43 synchronous early gastric carcinomas with a Krukenberg tumor and pericardial metastasis. Gastric Cancer; 2007;10(2):135-9
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  • [Title] A patient with 43 synchronous early gastric carcinomas with a Krukenberg tumor and pericardial metastasis.
  • A 53-year-old Japanese woman with bilateral ovarian tumors consulted our department.
  • Gastroendoscopy disclosed 16 superficial depressed gastric lesions, and the histopathological diagnosis of the biopsy specimens was poorly differentiated adenocarcinoma and signet-ring cell carcinoma.
  • Computed tomography (CT), ultrasonography (US), and positron emission tomography (PET) examinations revealed no other metastasis except for that observed in the ovaries.
  • We performed a total gastrectomy with radical lymph node dissection and bilateral ovarian resection.
  • Cancer cell invasion in the lymphatics was detected only in the submucosal region beneath the main tumor.
  • Both ovarian tumors were diagnosed as metastasis of signet-ring cell carcinoma (Krukenberg tumor).
  • Adjuvant chemotherapy with irinotecan (CPT-11) and low-dose cisplatin (CDDP) was given on an outpatient basis, but 1 year after the surgery, carcinomatous pericarditis occurred.
  • [MeSH-major] Adenocarcinoma / secondary. Heart Neoplasms / secondary. Krukenberg Tumor / secondary. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / secondary. Pericardium / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Cardiac Tamponade / etiology. Cardiac Tamponade / surgery. Fatal Outcome. Female. Gastrectomy. Humans. Lymphatic Metastasis / pathology. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 17577625.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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24. Yamazawa K, Matsui H, Ishikura H, Seki K, Mitsuhashi A, Sekiya S: Significance of perivascular lymphocytic infiltrates on survival of patients with invasive cervical cancer. J Immunother; 2003 Mar-Apr;26(2):149-55
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  • [Title] Significance of perivascular lymphocytic infiltrates on survival of patients with invasive cervical cancer.
  • The authors retrospectively reviewed the medical records of 129 patients with stage IB and II cervical cancer (93 squamous cell carcinomas, 30 adenocarcinomas, and 6 adenosquamous carcinomas) who underwent primary surgery between 1989 and 2000.
  • Vascular invasion is the predictor of recurrence, and lymphocytic infiltrates within the tumor is associated with favorable outcome in cervical cancer.
  • Age, clinical stage, histology, tumor grade, depth of stromal invasion, VI and PLI, tumor size, ovarian metastasis, pelvic lymph node metastasis, postoperative irradiation, and chemotherapy were assessed statistically for recurrence of the disease by Cox regression analysis.
  • Disease-free survival was analyzed using Kaplan-Meier survival analysis.
  • [MeSH-major] Lymphatic Metastasis / pathology. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Uterine Cervical Neoplasms / mortality. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Biopsy, Needle. Carcinoma, Adenosquamous / mortality. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / surgery. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Disease-Free Survival. Female. Humans. Hysterectomy / methods. Immunohistochemistry. Japan. Lymph Node Excision. Middle Aged. Multivariate Analysis. Probability. Prognosis. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Survival Analysis


25. Kadikoylu G, Barutca S, Tataroglu C, Kafkas S, Erpek H, Meydan N, Yavasoglu I, Bolaman Z: Thrombotic thrombocytopenic purpura as the first manifestation of metastatic adenocarcinoma in a young woman. Transfus Apher Sci; 2010 Feb;42(1):39-42
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  • [Title] Thrombotic thrombocytopenic purpura as the first manifestation of metastatic adenocarcinoma in a young woman.
  • Thrombotic microangiopathy occurs in 5-10% of patients with mucin-producing disseminated adenocarcinoma.
  • Thrombotic thrombocytopenic purpura (TTP) was diagnosed and therapeutic plasma exchange was performed on the patient.
  • On day 5 a laparotomy had to be performed because of acute abdomen due to the rupture of a corpus hemorrhagicum follicle of an ovary.
  • Signet ring cell adenocarcinoma stained with cytokeratin 7 and mucicarmine was seen on ovaries and bone marrow, after the pathological examination.
  • The primary site of tumor could not be investigated, because of the patient's refusal.
  • Although chemotherapy including cis-platinum, infusional 5-fluorouracil, and calcium leucovorin were administered in two courses, she died from respiratory failure.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Bone Marrow Neoplasms / secondary. Carcinoma, Signet Ring Cell / secondary. Neoplasms, Unknown Primary / complications. Ovarian Neoplasms / secondary. Purpura, Thrombotic Thrombocytopenic / etiology
  • [MeSH-minor] Abdomen, Acute / etiology. Abdomen, Acute / surgery. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Cisplatin / administration & dosage. Fatal Outcome. Female. Fluorouracil / administration & dosage. Hemoperitoneum / complications. Hemoperitoneum / surgery. Humans. Laparotomy. Leucovorin / administration & dosage. Plasma Exchange. Respiratory Insufficiency / etiology

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  • [Copyright] (c) 2009. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19926523.001).
  • [ISSN] 1473-0502
  • [Journal-full-title] Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • [ISO-abbreviation] Transfus. Apher. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; Q20Q21Q62J / Cisplatin; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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26. Singh S, Gupta P, Khanna R, Khanna AK: Simultaneous breast and ovarian metastasis from gallbladder carcinoma. Hepatobiliary Pancreat Dis Int; 2010 Oct;9(5):553-4
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  • [Title] Simultaneous breast and ovarian metastasis from gallbladder carcinoma.
  • BACKGROUND: Gallbladder carcinoma is a common malignancy in the Indian subcontinent.
  • A common extra-abdominal site of metastasis is the lungs.
  • Simultaneous metastasis to breast and ovary is extremely rare.
  • METHOD: This report describes an unusual case of carcinoma gallbladder metastasizing to the breast and ovary at the same time.
  • Ultrasound of the abdomen revealed hepatomegaly with thick-walled gallbladder with multiple stones and a mass at the fundus, but normal uterus and ovary.
  • Contrast-enhanced computer tomography of the abdomen showed a gallbladder mass infiltrating the liver parenchyma.
  • Histopathological examination revealed a poorly-differentiated adenocarcinoma with mar-gins free from tumor infiltration.
  • One month after surgery she developed a breast lump.
  • Ultrasound of the abdomen for metastatic workup revealed an ovary mass.
  • Simple mastectomy and salphingo-opherectomy were performed, and histopathological examination revealed a metastatic adenocarcinoma.
  • The patient is now on chemotherapy with gemcitabin.
  • CONCLUSION: This is an unusual case of carcinoma of the gallbladder with metastasis to the breast and ovary, which has not been documented before.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / secondary. Gallbladder Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cholecystectomy. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Female. Humans. Mastectomy. Middle Aged. Ovariectomy. Salpingectomy

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  • (PMID = 20943468.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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27. Klasa-Mazurkiewicz D, Narkiewicz J, Milczek T, Lipińska B, Emerich J: Maspin overexpression correlates with positive response to primary chemotherapy in ovarian cancer patients. Gynecol Oncol; 2009 Apr;113(1):91-8
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  • [Title] Maspin overexpression correlates with positive response to primary chemotherapy in ovarian cancer patients.
  • Experimental studies revealed that maspin suppresses tumor growth, angiogenesis, invasion and metastasis.
  • We examined maspin expression in human ovarian tumors and relation between maspin expression and clinicopathological features as well as the role of maspin in predicting clinical outcome in patients with ovarian cancer.
  • METHODS: Tissue samples consisted of 42 benign tumors, 10 borderline (LMP) tumors, 76 ovarian carcinomas, 8 Krukenberg tumors and 32 normal tissues.
  • RESULTS: Relative maspin level was significantly higher in patients with LMP tumors (median 0.74) and early stages ovarian cancers (median 0.46) when compared with healthy tissues (median 0.03), those with benign (median 0.23) and metastatic tumors (median 0.22).
  • Overexpression of maspin was found to correlate with the early stage of the disease (p=0.001), non-serous subtype of ovarian cancer (p=0.03) and positive response to chemotherapy (p=0.02).
  • CONCLUSIONS: Maspin is upregulated in borderline tumors and the early stages of ovarian carcinoma and then significantly downregulated with malignant transformation.
  • High expression may paradoxically promote the invasion and metastasis of ovarian carcinomas.
  • Our study revealed that maspin expression could play an important role in predicting the results of treatment of ovarian cancer patients.
  • [MeSH-major] Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / metabolism. Serpins / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blotting, Western. Female. Humans. Krukenberg Tumor / drug therapy. Krukenberg Tumor / metabolism. Krukenberg Tumor / pathology. Middle Aged. Neoplasm Staging. Prognosis. Young Adult

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  • (PMID = 19193429.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SERPIN-B5; 0 / Serpins
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28. Gold JS, Jaques DP, Bentrem DJ, Shah MA, Tang LH, Brennan MF, Coit DG: Outcome of patients with known metastatic gastric cancer undergoing resection with therapeutic intent. Ann Surg Oncol; 2007 Feb;14(2):365-72
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  • [Title] Outcome of patients with known metastatic gastric cancer undergoing resection with therapeutic intent.
  • BACKGROUND: Metastatic gastric cancer has a dismal prognosis.
  • We identified a subset of patients where surgical resection with therapeutic intent was undertaken in the setting of known metastatic disease.
  • METHODS: Review of a prospectively maintained database of gastric cancer patients at a single institution over a 19-year period was performed.
  • RESULTS: Thirty-seven patients with metastatic disease known prior to resection with therapeutic intent were identified out of 3384 patients with gastric cancer (1%).
  • Twelve patients had positive peritoneal cytology as the only evidence of metastasis, 21 had gross metastasis limited to peritoneal surfaces, one had peritoneal and ovarian metastasis, one had liver metastasis, one had retropancreatic lymph node metastasis, and one had a malignant pleural effusion.
  • Thirty-six patients (97%) received chemotherapy prior to resection, and 30 (81%) received postoperative chemotherapy.
  • The median time from diagnosis to resection was 4.5 months (range 1-22) in patients receiving preoperative chemotherapy.
  • Predictors of worse prognosis were cytologic or pathologic evidence of persistent metastatic disease at the time of resection or at laparoscopy within six weeks of resection (P < .01), N3 disease (P = .03), and total gastrectomy or additional organ resection (P = .04).
  • Metastatic disease as evidenced by cytology only was not associated with improved prognosis.
  • CONCLUSIONS: Highly selected patients with metastatic gastric cancer undergoing surgical resection with therapeutic intent have a relatively poor prognosis.
  • Persistent detectable metastatic disease after preoperative chemotherapy portends a particularly poor prognosis.
  • [MeSH-major] Stomach Neoplasms / secondary. Stomach Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Female. Gastrectomy. Humans. Lymph Node Excision. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17146744.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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29. Yamagishi Y, Akiba Y, Izumiya M, Higuchi H, Iizuka H, Takaishi H, Nagata H, Hibi T: [A case of advanced gastric cancer with lymphangitis carcinomatosa after operation of Krukenberg tumor treated by TS-1 plus CPT-11 as third-line chemotherapy]. Gan To Kagaku Ryoho; 2005 Aug;32(8):1167-70
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  • [Title] [A case of advanced gastric cancer with lymphangitis carcinomatosa after operation of Krukenberg tumor treated by TS-1 plus CPT-11 as third-line chemotherapy].
  • Chemotherapies for recurrent gastric cancer have not yet been established.
  • Here we report a case of type 4 gastric cancer associated with lymphangitis carcinomatosis which became refractory to the previous chemotherapies.
  • She had been diagnosed with gastric cancer after a Krukenberg tumor operation.
  • Disease activity has been well controlled until this time.
  • Since recurrence of left pleural effusion and lymphangitis carcinomatosis was recognized, we changed the chemotherapy TS-1 plus CPT-11.
  • The serum CA 19-9 level rose transiently after CPT-11 administration, and tended to fall at the second week of chemotherapy.
  • TS-1 plus CPT-11 combination chemotherapy would be effective for lymphangitis carcinomatosis and also useful as third-line chemotherapy for recurrent gastric cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Krukenberg Tumor / surgery. Lymphangitis / complications. Ovarian Neoplasms / surgery. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Adult. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Drug Combinations. Female. Humans. Oxonic Acid / administration & dosage. Pyridines / administration & dosage. Tegafur / administration & dosage

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  • (PMID = 16121922.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents, Phytogenic; 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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30. Sandmeier D, Lobrinus JA, Vial Y, Delaloye JF, Genton CY: Bilateral Krukenberg tumor of the ovary during pregnancy. Eur J Gynaecol Oncol; 2000;21(1):58-60
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  • [Title] Bilateral Krukenberg tumor of the ovary during pregnancy.
  • Large bilateral ovarian tumors were observed which were interpreted as pregnancy luteomas.
  • Nevertheless a biopsy of the right ovary was performed.
  • Histologic examination revealed massive luteinization of the ovarian stroma.
  • In addition, large tumor cells were found dispersed throughout the ovary as well as in vascular spaces as either isolated or clustered signet-ring cells.
  • In search of the primary tumor, gastroscopy revealed a gastric ulcer in the antrum.
  • The biopsies of the ulcer margins as well as those taken at distance demonstrated signet-ring cells in the lamina propria.
  • In spite of postoperative chemotherapy, the patient died of disease 5 months after diagnosis.
  • [MeSH-major] Krukenberg Tumor / secondary. Luteoma / pathology. Ovarian Neoplasms / secondary. Pregnancy Complications, Neoplastic / pathology. Stomach Neoplasms / pathology


31. Wong FC, Pang CP, Tang SK, Tung SY, Leung TW, Sze WK, Cheung KB: Treatment results of endometrial carcinoma with positive peritoneal washing, adnexal involvement and serosal involvement. Clin Oncol (R Coll Radiol); 2004 Aug;16(5):350-5
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  • [Title] Treatment results of endometrial carcinoma with positive peritoneal washing, adnexal involvement and serosal involvement.
  • AIMS: To review the treatment results of patients with endometrial carcinoma having positive peritoneal washing (PPW), adnexal involvement, uterine serosal involvement, or all three.
  • MATERIALS AND METHODS: The treatment records of patients who had undergone primary surgery for endometrial cancer without distant metastasis during 1990--2001 at the Department of Clinical Oncology, Tuen Mun Hospital, Hong Kong, were reviewed.
  • Seven (20%) of them had gross or microscopic lymph-node metastasis.
  • Two patients with solitary ovarian metastasis received chemotherapy, and one with isolated PPW also received adjuvant hormonal therapy.
  • RESULTS: Among the 28 patients with clinical or pathological node-negative disease (International Federation of Gynecology and Obstetrics [FIGO] stage IIIA), only two patients with solitary ovarian metastases developed recurrence.
  • The 5-year actuarial disease-free survival (DFS) rates for the whole group and patients without lymph-node involvement were 77.9% and 91.7%, respectively.
  • Five out of the seven patients with lymph-node involvement developed recurrences.
  • Univariate analysis showed that lymph-node involvement (P < 0.0001) and high-grade disease (P = 0.011) were the significant poor prognostic factors.
  • Only one patient (3.7%) who had received WART developed grade 4 toxicity.
  • CONCLUSIONS: This study showed that good treatment results could be obtained from patients with stage IIIA endometrial carcinoma without clinical or pathological lymph-node involvement after adjuvant radiotherapy, with acceptable late side-effects.
  • The relative prognostic importance of individual IIIA involvement and the optimal adjuvant treatment remain to be determined.
  • [MeSH-major] Ascitic Fluid / pathology. Endometrial Neoplasms / pathology. Endometrial Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Middle Aged. Multivariate Analysis. Myometrium / pathology. Neoplasm Staging. Ovary / pathology. Prognosis. Proportional Hazards Models. Radiotherapy, Adjuvant. Review Literature as Topic. Risk Factors. Survival Rate. Treatment Outcome

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  • (PMID = 15341439.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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32. Garin L, Corbinais S, Boucher E, Blanchot J, Le Guilcher P, Raoul JL: Adenocarcinoid of the appendix vermiformis: complete and persistent remission after chemotherapy (folfox) of a metastatic case. Dig Dis Sci; 2002 Dec;47(12):2760-2
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  • [Title] Adenocarcinoid of the appendix vermiformis: complete and persistent remission after chemotherapy (folfox) of a metastatic case.
  • All pathology specimens exhibited an adenocarcinomatous component associated with carcinoid proliferation related to an appendicular tumor leading to the diagnosis of appendicular adenocarcinoid with ovarian, peritoneal, and nodal metastases.
  • The patient's general status worsened rapidly with widespread nodal metastasis.
  • Chemotherapy (Folfox 4 regimen) was given, and the patient improved within six weeks.
  • Presently, more than three years after the end of the treatment, the patient is still alive and in complete remission.
  • These tumors exhibit two cellular components.
  • Ovarian metastasis is frequent.
  • Prognosis is intermediate between adenocarcinoma and malignant carcinoid.
  • When given to patients with colonic carcinoma, the Folfox regimen used effectively here, is associated with a 50% objective response but complete response is very exceptional.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Appendiceal Neoplasms / drug therapy. Fluorouracil / therapeutic use. Leucovorin / therapeutic use
  • [MeSH-minor] Female. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Metastasis. Organoplatinum Compounds. Ovarian Neoplasms / secondary

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  • (PMID = 12498298.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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33. Jeremić K, Berisavac M, Argirović R, Gojnić M, Bosković V, Milenković V, Mostić T: Solitary ovarian metastasis from cutaneous melanoma--case report. Eur J Gynaecol Oncol; 2006;27(4):443-4
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  • [Title] Solitary ovarian metastasis from cutaneous melanoma--case report.
  • A 47-year-old patient with two previous deliveries and three deliberate abortions was admitted to the Institute of Gynecology and Obstetrics, Clinical Center of Serbia with the diagnosis of a uterine myoma and left adnexal mass.
  • Five years previously, she had undergone excision of a malignant melanoma from her left leg.
  • After ultrasound and computed tomography examination, the patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, intracolic omentectomy and selective pelvic lymphonodectomy.
  • The final histopathological diagnosis was metastatic amelanotic malignant melanoma of the left ovary and uterine myomas.
  • After surgery the patient was transferred to the Institute of Oncology and Radiology where she received chemotherapy.
  • [MeSH-major] Melanoma / secondary. Ovarian Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 17009650.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CA-125 Antigen
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34. Lee SJ, Lee J, Lim HY, Kang WK, Choi CH, Lee JW, Kim TJ, Kim BG, Bae DS, Cho YB, Kim HC, Yun SH, Lee WY, Chun HK, Park YS: Survival benefit from ovarian metastatectomy in colorectal cancer patients with ovarian metastasis: a retrospective analysis. Cancer Chemother Pharmacol; 2010 Jul;66(2):229-35
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  • [Title] Survival benefit from ovarian metastatectomy in colorectal cancer patients with ovarian metastasis: a retrospective analysis.
  • PURPOSE: A recent study demonstrated that colorectal cancer (CRC) with ovarian metastases was less responsive to chemotherapy compared with extraovarian metastases.
  • Hence, the ovary may actually represent a "sanctuary" for metastatic cells from CRC.
  • The aim of the study was to investigate the impact of ovarian metastatectomy on survival of CRC patients with ovarian metastasis.
  • For the historical control, 47 CRC patients with ovarian metastasis without resection were included in the analysis.
  • The proportion of synchronous metastasis was higher in the oophorectomy group than in the control group (57 vs. 30%; P = 0.003).
  • For ovary-specific survival (date of ovarian metastasis diagnosis to death), CRC patients with an oophorectomy showed a significantly more favorable survival rate than the control group (20.8 vs. 10.9 months; P < 0.001).
  • In univariate analyses, oophorectomy (P = 0.038), unilaterality of ovarian metastasis (P = 0.032), metastasis confined to ovaries (P < 0.001), normal CEA level (P < 0.001), good performance status (P = 0.001), palliative chemotherapy (P = 0.001), and primary disease resection (P = 0.005) were identified as significantly good prognostic factors for overall survival.
  • The oophorectomy, chemotherapy, metastasis confined to ovaries, normal CEA level, and good performance status retained statistical significance at the multivariate level (P = 0.003, P = 0.004, P = 0.005, P = 0.015, and P = 0.029, respectively).
  • CONCLUSIONS: Based on this retrospective analysis, the ovarian metastatectomy significantly prolonged survival in CRC patients with ovarian metastases.
  • The potential role of an ovarian metastatectomy in the management of CRC should be prospectively studied.
  • [MeSH-major] Colorectal Neoplasms / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Ovary / surgery
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Factor Analysis, Statistical. Female. Humans. Kaplan-Meier Estimate. Middle Aged. Ovariectomy. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome


35. Nishimura T, Maeda Y, Okada T, Nakamura M, Sakata K, Setoguchi M, Kawasaki N: [Ovarian metastasis after complete response of colon cancer]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2263-5
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  • [Title] [Ovarian metastasis after complete response of colon cancer].
  • We report a case of ovarian metastasis after complete response of colon cancer.
  • A 55-year-old woman underwent a sigmoidectomy for sigmoid colon cancer with hepatic metastasis and para-aorta lymph node metastasis.
  • After the operation, the patient was given chemotherapy with bevacizumab+mFOLFOX6.
  • Thirteen months after the operation, right ovarian tumor was found and bilateral oophrectomy, hysterectomy and omentectomy were performed.
  • Histopathologically the ovarian tumor was metastasized from colonic cancer.
  • After the second operation, the patient was given chemotherapy with bevacizumab+FOLFIRI.
  • At present, the patient remains disease-free for 6 months after the ovarian operation.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Ovarian Neoplasms / secondary

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  • (PMID = 20037390.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 2S9ZZM9Q9V / Bevacizumab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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36. mukai M, Moriya H, Himeno S, Oida Y, mukohyama S, Nishi T, Nakasaki H, Satoh S, Makuuchi H: Efficacy of oral UFT plus leucovorin therapy for colon cancer with ovarian and multiple liver metastases: report of two cases. Oncol Rep; 2001 Sep-Oct;8(5):1079-83
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  • [Title] Efficacy of oral UFT plus leucovorin therapy for colon cancer with ovarian and multiple liver metastases: report of two cases.
  • Case 1: a patient was diagnosed as having ascending colon cancer with right ovarian metastasis, and underwent palliative right hemicolectomy plus oophorectomy.
  • The tumor was a well-differentiated adenocarcinoma with right ovarian metastasis, and the disease was classified as stage IV.
  • Oral chemotherapy with UFT plus LV was performed for about 3 years, and the patient is still being followed up with no recurrence at 5 years postoperatively.
  • Case 2: a patient was diagnosed as having incomplete large bowel obstruction caused by ascending colon cancer, and underwent curative right hemicolectomy.
  • The tumor was a moderately differentiated adenocarcinoma, and the disease was classified as stage II.
  • Since multiple liver metastases developed at 3 months postoperatively, oral chemotherapy with UFT plus LV was started.
  • Subsequently, liver metastasis recurred about 10 months later.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Leucovorin / therapeutic use. Liver Neoplasms / drug therapy. Ovarian Neoplasms / drug therapy. Tegafur / therapeutic use. Uracil / therapeutic use
  • [MeSH-minor] Administration, Oral. Adult. Aged. Aged, 80 and over. Colectomy. Female. Humans. Neoplasm Staging. Ovariectomy. Postoperative Period. Remission Induction. Tomography, X-Ray Computed


37. Yu L, Li X, Yang W: Pulmonary blastoma metastatic to the ovary. Int J Gynecol Pathol; 2009 Jan;28(1):59-62
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  • [Title] Pulmonary blastoma metastatic to the ovary.
  • A 38-year-old woman was diagnosed as biphasic PB (1 subgroup of sarcomatoid carcinoma) and treated by surgery, radiotherapy, and chemotherapy.
  • Six months later, the patient presented with menstrual disorder and a mass in the abdominal-pelvic cavity.
  • Abdominal hysterectomy and bilateral salpingo-oophorectomy showed the morphology of metastatic PB in both ovaries.
  • The metastatic tumor was composed exclusively of epithelial components resembling well-differentiated fetal adenocarcinoma.
  • To our knowledge, this is the first reported case of bilateral ovarian metastasis from biphasic PB.
  • [MeSH-major] Lung Neoplasms / pathology. Ovarian Neoplasms / secondary. Pulmonary Blastoma / secondary

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  • [CommentIn] Int J Gynecol Pathol. 2010 Jul;29(4):339-40 [20567146.001]
  • (PMID = 19047906.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Kunz J, Makek M: [Primary adenocarcinoma of the appendix as differential diagnosis of advanced ovarian carcinoma]. Praxis (Bern 1994); 2006 Aug 16;95(33):1217-25
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  • [Title] [Primary adenocarcinoma of the appendix as differential diagnosis of advanced ovarian carcinoma].
  • [Transliterated title] Das primäre Adenokarzinom der Appendix als Differentialdiagnose des fortgeschrittenen Ovarialkarzinoms.
  • Malignant tumours of the appendix are rare.
  • They are usually carcinoid tumours that must be distinguished from extremely rare adenocarcinomas.
  • Metastatic mucinous adenocarcinomas of the appendix are only reported as case histories.
  • In clinical terms, the tumours usually manifest themselves as acute appendicitis, as ruptured appendicitis, as a tumour in the right lower abdominal quadrant or as a pelvic tumour, which are generally mistaken for an ovarian tumour with the same sonographic image.
  • Advanced primary adenocarcinomas of the appendix with ovarian metastases cannot be distinguished intraoperatively from a FIGO III ovarian carcinoma.
  • The pathologist makes the definitive diagnosis.
  • Surgical therapy of the isolated primary appendiceal carcinoma consists of a hemicolectomy--an appendectomy in favourable cases--and, in the case of a metastasised carcinoma, according to the guidelines for an advanced ovarian or colon carcinoma.
  • The effect of chemotherapy is insufficiently documented.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / secondary. Appendiceal Neoplasms / diagnosis. Carcinoma, Signet Ring Cell / diagnosis. Carcinoma, Signet Ring Cell / secondary. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary
  • [MeSH-minor] Appendix / pathology. Appendix / surgery. Diagnosis, Differential. Female. Humans. Hysterectomy, Vaginal. Middle Aged. Omentum / pathology. Omentum / surgery. Ovary / pathology. Ovary / surgery. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Peritoneum / pathology. Peritoneum / surgery. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Postoperative Complications / surgery. Reoperation

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  • (PMID = 16939122.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Switzerland
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39. Xu L, Zhan YQ: [Clinical analysis of 55 ovarian metastatic tumors from digestive system]. Ai Zheng; 2002 Mar;21(3):311-3
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  • [Title] [Clinical analysis of 55 ovarian metastatic tumors from digestive system].
  • BACKGROUND & OBJECTIVES: Ovarian metastasis of digestive system tumors is a special way of tumor metastasis, which the diagnosis and treatment are difficult.
  • The objective of this paper is to seek the clinical characteristics of ovarian metastatic tumors from digestive system, to aid correct diagnosis and treatment, so that to improve their curative effect.
  • METHODS: The authors collected the information of 55 patients with ovarian metastatic tumors from digestive system, and analyzed 12 items of the patients including their age, menorrhea and child-bearing, details of original tumors and metastatic tumors, pathologic types, ascites, clinical symptoms, tumor markers, time of metastasis, diagnosis, treatment, curative effect, etc.
  • CONCLUSION: Ovarian metastatic tumors from digestive system are easy to be misdiagnosed, and have poor prognosis.
  • Careful long-term follow-up and active operation and chemotherapy may be effective to improve their curative effect.
  • [MeSH-major] Diagnostic Errors. Digestive System Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Female. Humans. Middle Aged. Neoplasm Metastasis

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  • (PMID = 12452002.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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40. Taylor J, Amanze A, Di Federico E, Verschraegen C: Irinotecan use during pregnancy. Obstet Gynecol; 2009 Aug;114(2 Pt 2):451-2
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  • BACKGROUND: Ovarian tumors during pregnancy are rare.
  • There is sparse clinical evidence about the safety of chemotherapy in this situation.
  • CASE: A 34-year-old woman was diagnosed by ultrasonography at 15 1/2 weeks of pregnancy with a Krukenberg tumor.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Camptothecin / analogs & derivatives. Krukenberg Tumor / therapy. Ovarian Neoplasms / therapy. Pregnancy Complications, Neoplastic / therapy. Prenatal Care

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  • (PMID = 19622957.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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41. Zanetta G, Gabriele A, Vecchione F, Landoni F, Isimbaldi G: Unusual recurrence of cervical adenosquamous carcinoma after conservative surgery. Gynecol Oncol; 2000 Mar;76(3):409-12
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  • [Title] Unusual recurrence of cervical adenosquamous carcinoma after conservative surgery.
  • The use of less radical procedures for the treatment of early cervical cancers is gaining interest among physicians and young patients.
  • After a polypectomy, a young patient had a diagnosis of stage Ia(2) cervical adenosquamous carcinoma in 1995.
  • As she wished to preserve her fertility, she underwent a cone biopsy and pelvic lymphadenectomy, without evidence of tumor spread.
  • In 1998, at the 13th week of gestation, she had a diagnosis of a pelvic mass.
  • The mass was a recurrence of carcinoma involving the myometrium, just underneath the peritoneum.
  • An ovarian metastasis was also detected at pathological exam.
  • She received chemotherapy postoperatively and remains alive without evidence of disease.
  • The recurrence of cervical cancer is traditionally regarded as an issue concerning the cervix, the parametria, or the lymph nodes.
  • With wider acceptance of limited therapeutic approaches we must be prepared for the detection of previously unknown patterns of recurrence and the follow-up modalities must be consequently adapted.
  • [MeSH-major] Carcinoma, Adenosquamous / secondary. Carcinoma, Adenosquamous / surgery. Neoplasm Recurrence, Local. Ovarian Neoplasms / secondary. Pregnancy Complications, Neoplastic. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / surgery
  • [MeSH-minor] Adult. Conization. Female. Humans. Lymph Node Excision. Neoplasm Invasiveness. Pregnancy. Uterine Neoplasms / pathology. Uterine Neoplasms / surgery


42. Chudy B, Łata S: [49 year old patient with staphylococcal sepsis caused by agranulocytosis after polychemotheraphy]. Przegl Lek; 2010;67(5):440-1
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  • This study presents a case of adverse effects of chemotherapeutic agents: alkylating drug (cisplatyna) and taksoin (taxol) on a patient with metastatic cancer of unknown primary which was manifesting with Krukenberg tumor symptoms.
  • The main disease symptoms were caused by bone marrow malignant infiltrations, and pancytopenia in peripheral blood, but mainly staphylococcal sepsis and hemorrhagic diathesis.
  • In conclusion, the need to be cautious while making the decision to implement chemotherapy on patients with very advanced cancer in terms of prolonging their lives was pointed out.
  • [MeSH-major] Agranulocytosis / etiology. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Bone Marrow Neoplasms / secondary. Neoplasms, Unknown Primary / drug therapy. Sepsis / etiology. Staphylococcal Infections / etiology
  • [MeSH-minor] Cisplatin / administration & dosage. Female. Humans. Krukenberg Tumor / diagnosis. Krukenberg Tumor / drug therapy. Krukenberg Tumor / secondary. Middle Aged. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / drug therapy. Paclitaxel / administration & dosage

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  • (PMID = 20684357.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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43. Skírnisdóttir I, Garmo H, Holmberg L: Non-genital tract metastases to the ovaries presented as ovarian tumors in Sweden 1990-2003: occurrence, origin and survival compared to ovarian cancer. Gynecol Oncol; 2007 Apr;105(1):166-71
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  • [Title] Non-genital tract metastases to the ovaries presented as ovarian tumors in Sweden 1990-2003: occurrence, origin and survival compared to ovarian cancer.
  • OBJECTIVE: The aim of this register study was to determine occurrence of non-genital ovarian metastasis detected by gynecologic surgery presented as ovarian neoplasm in Sweden from 1 January 1990 to 31 December 2003.
  • Origin of metastases and time of detection in relation to surgery were recorded.
  • Age at diagnosis, survival for ovarian metastasis compared to ovarian cancer and prognostic factors were evaluated.
  • METHODS: Utilizing the population-based Swedish In-Patient Registry, Cancer Registry and Causes of Death Registry, we identified 255 cases with non-genital tract metastases to the ovaries detected at gynecological surgery.
  • During the study period, 10,955 newly diagnosed cases of ovarian cancer were reported to the Swedish Cancer Registry.
  • RESULTS: The proportion of ovarian metastases detected at surgery of all ovarian neoplasm increased from 1.7% to 3.0% during the study period.
  • The patients with ovarian metastasis of non-GI origin were younger than patients with primary ovarian cancer.
  • The most common primary diseases were breast cancer (29%), colon cancer (27%) and gastric cancer (16%).
  • Ovarian metastasis of GI origin preceded primary diagnosis in 51% of patients but for women with disease of non-GI origin the primary diagnosis was made in 18% of patients after surgery.
  • Five-year survival for patients with ovarian metastasis of GI origin was 11% and it was 24% if metastases were of non-GI origin.
  • Five-year survival for women with ovarian metastases from breast cancer was 26%.
  • In a multivariate analysis, GI surgery at primary surgery for ovarian metastasis was unfavorable prognostic factor.
  • Diagnosis of primary disease known before surgery, primary disease of non-GI or unknown origin and operation at university hospital all had favorable prognostic impact for overall survival.
  • CONCLUSIONS: Detection of non-genital ovarian metastasis at gynecologic surgery is associated with poor prognosis, and prognosis is worse in tumors with GI origin and if the primary is not detected prior to surgery.
  • The results indicate that a thorough patient evaluation is very important before surgery for suspected ovarian neoplasm.
  • [MeSH-major] Ovarian Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Incidence. Middle Aged. Proportional Hazards Models. Registries. Survival Rate. Sweden / epidemiology

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  • [ErratumIn] Gynecol Oncol. 2007 Jul;106(1):276
  • (PMID = 17184826.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Akiba Y, Watanabe C, Takada Y, Naito K, Aoki D, Mukai M, Kato S, Hibi T, Ishii H: [A case of type 4 gastric cancer, diagnosed after operation for Krukenberg's tumor, treated by TS-1 plus low-dose cisplatinum]. Gan To Kagaku Ryoho; 2003 Feb;30(2):277-81
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  • [Title] [A case of type 4 gastric cancer, diagnosed after operation for Krukenberg's tumor, treated by TS-1 plus low-dose cisplatinum].
  • Survival of patients with advanced gastric cancer with Krukenberg's tumor is poor.
  • We report the case of a good response in a 37-year-old woman who had type 4 gastric cancer, diagnosed after the operation of Krukenberg's tumor, and then was treated with TS-1, a DPD inhibitory fluoropyrimidine, in combination with a low-dose cisplatinum (CDDP).
  • Endoscopic gastric biopsy showed signet-ring cell adenocarcinoma and moderately differentiated tubular adenocarcinoma, and computed tomography (CT) showed the para-aortic lymph node metastasis before the chemotherapy.
  • After the first course, gastric biopsy did not show any cancer cells and lymph node metastasis had disappeared.
  • Serum CA19-9 decreased gradually week by week during the chemotherapy, even during the washout period after the first course, and was normalized after two courses.
  • This case suggests that the combination of TS-1 and low-dose CDDP is effective against type 4 advanced gastric cancer.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Signet Ring Cell / drug therapy. Krukenberg Tumor / surgery. Neoplasms, Multiple Primary. Ovarian Neoplasms / surgery. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Drug Administration Schedule. Drug Combinations. Female. Humans. Infusions, Intravenous. Lentinan / administration & dosage. Ondansetron / administration & dosage. Oxonic Acid / administration & dosage. Pyridines / administration & dosage. Tegafur / administration & dosage

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  • (PMID = 12610879.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 37339-90-5 / Lentinan; 4AF302ESOS / Ondansetron; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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45. Hornung M, Vogel P, Schubert T, Schlitt HJ, Bolder U: A case of virilization induced by a Krukenberg tumor from gastric cancer. World J Surg Oncol; 2008;6:19
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  • [Title] A case of virilization induced by a Krukenberg tumor from gastric cancer.
  • BACKGROUND: The Krukenberg tumor represents ovarian metastases associated with gastric cancer or other gastrointestinal malignancies.
  • Histology shows typical mucus-production and numerous signet-ring cells.
  • Occasionally Krukenberg tumors have endocrine function and, as a consequence, some patients demonstrate hirsutism and virilization.
  • CASE PRESENTATION: Here we report a case of virilization associated with an extensive gastric adenocarcinoma and Krukenberg tumor in a premenopausal woman.
  • Virilization occurred three months after diagnosis of gastric cancer and the ovarian tumors.
  • Palliative chemotherapy was initiated as primary therapy, but gastric outlet obstruction required a gastrojejunostomy.
  • In addition, oopherectomy was performed to relieve abdominal tension and to abate hormonal effects.
  • CONCLUSION: Despite the limitation in survival time early oopherectomy should be considered to prevent the development of virilization even in palliative situations if a Krukenberg tumor is diagnosed with gastric cancer.
  • [MeSH-major] Carcinoma, Signet Ring Cell / therapy. Krukenberg Tumor / therapy. Ovarian Neoplasms / therapy. Virilism / etiology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Fatal Outcome. Female. Gastric Bypass. Gastric Outlet Obstruction / etiology. Gastric Outlet Obstruction / surgery. Humans. Ovariectomy. Palliative Care. Premenopause. Stomach Neoplasms / pathology

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  • (PMID = 18279511.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2275731
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46. Morimoto Y, Imai S, Matsumoto T, Kunisue M, Kawasaki S, Yamaguchi K, Okabe M, Kawamoto K, Ito T, Ogasawara K: [A case of Stage IV non-operated advanced breast cancer with local recurrence thirteen years after initial therapy]. Gan To Kagaku Ryoho; 2007 Oct;34(10):1693-5
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  • [Title] [A case of Stage IV non-operated advanced breast cancer with local recurrence thirteen years after initial therapy].
  • A 73-year-old woman underwent chemotherapy, radiotherapy, and hormonal therapies for right advanced breast cancer (T4, N3, M1, Stage IV) in 1993.
  • For adjuvant therapies, she had been treated with hormonal therapies for five years until 2003.
  • After the interruption of hormonal therapies, the serum levels of tumor markers had been elevated, and she had a right axillary local recurrence and a right ovarian metastasis detected by a FDG-PET/CT in February 2006.
  • The right axillary local recurrence lesion was then resected, and she has since been treated with hormonal therapy of aromatase inhibitor (AI).
  • The serum levels of tumor markers have been remarkably reduced, and FDG-PET/CT has showed the disappearance of the right axillary local recurrence, and the decrease of FDG accumulation of the right ovarian metastases in February 2007.
  • We present a case of non-operated advanced breast cancer with local recurrence surviving successfully long term when treated with AI.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / therapy. Neoplasm Recurrence, Local
  • [MeSH-minor] Aged. Aromatase Inhibitors / therapeutic use. Biomarkers, Tumor / blood. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Humans. Ovarian Neoplasms / secondary

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  • (PMID = 17940393.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 0 / Biomarkers, Tumor
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47. Sasaki H, Idani F, Asami S, Komoto S, Kubota T, Kumano K, Kurose Y, Kubo S, Nojima H, Yoshioka T, Muro M, Kin H, Takakura N: [A long-term survival case of bilateral ovarian metastasis of progressive gastric cancer treated by chemotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2478-80
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  • [Title] [A long-term survival case of bilateral ovarian metastasis of progressive gastric cancer treated by chemotherapy].
  • We report a long-term survival case treated by chemotherapy with new anticancer drugs such as S-1, CPT-11 and docetaxel after bilateral overiectomy for bilateral ovarian metastases of progressive gastric cancer.
  • A 68-year-old female, who had undergone total gastrectomy with D2 lymphadenectomy for scirrhous gastric cancer of Stage IIIA, was admitted because of ovarian metastasis.
  • Laparoscopic bilateral ovariectomy was performed for ovarian metastases of the gastric cancer (Krukenberg tumor) 6 months after gastrectomy.
  • Seven months after gastrectomy, 11-course of S-1 treatment (80 mg/m2) for bilateral ovarian metastases of the gastric cancer was administered.
  • Then, the drug was changed to docetaxel (60 mg/m2).
  • After 9-course of docetaxel treatment, the mediastinal lymphadenopathy disappeared.
  • For a treatment of grade 3 neuropathy, a 12-course CPT-11 was started after gastrectomy 3 years and 6 months ago.
  • CT scan and PET-CT showed no new metastasis in 4 years and 10 months after gastrectomy.
  • [MeSH-major] Adenocarcinoma, Scirrhous / pathology. Krukenberg Tumor / drug therapy. Krukenberg Tumor / secondary. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Drug Combinations. Female. Gastrectomy. Humans. Ovariectomy. Oxonic Acid / administration & dosage. Taxoids / administration & dosage. Tegafur / administration & dosage

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  • (PMID = 21224612.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Drug Combinations; 0 / Taxoids; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 15H5577CQD / docetaxel; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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48. Mandai M, Konishi I, Tsuruta Y, Suginami N, Kusakari T, Iwasaki T, Fujii S: Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature. Eur J Obstet Gynecol Reprod Biol; 2001 Jul;97(1):90-5
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  • [Title] Krukenberg tumor from an occult appendiceal adenocarcinoid: a case report and review of the literature.
  • Appendiceal neoplasms with ovarian metastasis are rare.
  • A 35-year-old woman with a left ovarian tumor underwent left salpingo-oophorectomy, partial resection of the right ovary, and a total hysterectomy.
  • Pathological diagnosis of both ovaries was typical, Krukenberg tumor with signet-ring cells, and the second laparotomy revealed an occult appendiceal tumor to be the primary lesion.
  • The appendix showed no evidence of malignant change of the mucosa, but the tumor cells were observed infiltrating from the basiglandular region into the underlying stroma, associated with mucocele.
  • Although, argentaffin and argyrophil staining were negative, a few tumor cells showed immunohistochemical positivity for Chromogranin A.
  • Accordingly, the tumor was diagnosed as adenocarcinoid rather than adenocarcinoma of the appendix.
  • A review of the literature showed less than 40 cases of metastatic ovarian tumor from appendiceal primary, one-third of which were occult and could be detected at the second laparotomy.
  • Cisplatin-based chemotherapy may have partial effect in the treatment of patient with adenocarcinoid tumor.
  • [MeSH-major] Appendiceal Neoplasms / pathology. Carcinoid Tumor / pathology. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chromogranin A. Chromogranins / analysis. Cisplatin / therapeutic use. Fallopian Tubes / surgery. Fatal Outcome. Female. Humans. Hysterectomy. Immunohistochemistry. Intestinal Obstruction / etiology. Ovariectomy. Peritonitis / etiology


49. Singhal SR, Nanda S, Chaudhry P, Sen J, Singhal SK: Metastatic bilateral malignant ovarian tumors associated with pregnancy. Taiwan J Obstet Gynecol; 2009 Jun;48(2):167-8
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  • [Title] Metastatic bilateral malignant ovarian tumors associated with pregnancy.
  • OBJECTIVE: Krukenberg tumors in pregnancy are extremely rare.
  • CASE REPORT: A 20-year-old, primigravida with bilateral malignant ovarian tumors, who received no prior antenatal care, was presented with intestinal obstruction at 5 months' gestation.
  • The patient aborted spontaneously and postoperatively, and was treated with adjuvant chemotherapy.
  • CONCLUSION: Because platinum-based chemotherapy can be safely given during pregnancy, hysterectomy can be avoided in cases of bilateral malignant ovarian tumors if the uterus is not grossly involved, so allowing preservation of an existing pregnancy.
  • [MeSH-major] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / secondary. Colonic Neoplasms / pathology. Ovarian Neoplasms / secondary. Pregnancy Complications, Neoplastic / ultrasonography
  • [MeSH-minor] Abortion, Spontaneous. Adult. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Female. Humans. Omentum / surgery. Ovariectomy. Pregnancy. Young Adult

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  • [CommentIn] Taiwan J Obstet Gynecol. 2011 Sep;50(3):405-6; author reply 407 [22030067.001]
  • (PMID = 19574181.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin
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50. Toiyama Y, Inoue Y, Hiro J, Ojima E, Watanabe H, Miki C, Kusunoki M: Alteration of the chemoresistant gene expression during chemotherapy for colon cancer: a molecular case report. Oncol Rep; 2008 Mar;19(3):755-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alteration of the chemoresistant gene expression during chemotherapy for colon cancer: a molecular case report.
  • Chemotherapy remains the main choice of treatment for the management of unresectable or metastatic colorectal cancer.
  • However, drug resistance is a major problem, limiting the effectiveness of the chemotherapies presently used to treat cancer.
  • During treatment, drug resistance can also be acquired by tumors that are initially sensitive to chemotherapy.
  • We present a case of metachronous splenic recurrence after a curative resection of appendical cancer with ovarian metastasis, although the patient had been treated with 5-FU/LV followed by mFOLFOX6 after surgery.
  • Molecular analyses by RT-PCR also showed that the residual tumor after chemotherapy has cancer cells overexpressing 5-FU/l-OHP based chemotherapy-resistant genes.
  • Therefore, it was suggested that a careful assessment of the disease status be undertaken during chemotherapy to ensure that the possibility of surgical resection, especially of the re-growth or partial response tumors, was not missed, since several genes, chemoresistant to the agents used, can be induced in residual tumors during chemotherapy.
  • [MeSH-major] Colonic Neoplasms / drug therapy. Drug Resistance, Neoplasm / genetics
  • [MeSH-minor] Aged. Combined Modality Therapy. Enzymes / genetics. Enzymes / metabolism. Female. Humans. RNA, Messenger / metabolism. Splenic Neoplasms / pathology. Splenic Neoplasms / secondary

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  • (PMID = 18288412.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Enzymes; 0 / RNA, Messenger
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51. Nakayama N, Tanabe S, Koizumi W, Higuchi K, Sasaki T, Nakatani K, Shimoda T, Nishimura K, Kobayashi N, Mitomi H, Saigenji K: [A case of long-term survival of 3-years 4 months after combination chemotherapy of MTX, 5-FU and low-dose CDDP (MFP) for type 4 gastric cancer with pleuritis, peritoneal dissemination and Krukenberg tumor]. Gan To Kagaku Ryoho; 2006 Nov;33(11):1641-4
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  • [Title] [A case of long-term survival of 3-years 4 months after combination chemotherapy of MTX, 5-FU and low-dose CDDP (MFP) for type 4 gastric cancer with pleuritis, peritoneal dissemination and Krukenberg tumor].
  • Computed tomography and ultrasonography of the abdomen revealed bilateral ovarian tumors, massive ascites, and bilateral pleural effusion.
  • Type IV advanced gastric cancer was diagnosed on upper gastrointestinal endoscopy.
  • She received 3 courses of combination chemotherapy with methotrexate, 5-fluorouracil, and low-dose cisplatin.
  • Chemotherapy was repeated after surgery.
  • Lymph-node metastasis recurred 1 year 8 months after the start of chemotherapy.
  • Treatment was switched to irinotecan plus cisplatin, and the lymph nodes shrank.
  • Two years 10 months after starting chemotherapy, abdominal and low back pain developed.
  • Bone scintigraphy revealed bone metastasis.
  • The patient responded to radiotherapy with chemotherapy (cisplatin plus 5-fluorouracil).
  • Subsequently, abdominal computed tomography showed lymph-node swelling, multiple metastases to the liver, ascites, and a right pleural effusion.
  • She was readmitted to the hospital and received intraperitoneal chemotherapy with cisplatin.
  • The patient survived for about 3 years 4 months after the start of treatment.
  • Chemotherapy with methotrexate, 5-fluorouracil, and low-dose cisplatin may thus be an effective therapeutic option in patients who have advanced gastric cancer with peritoneal dissemination.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Krukenberg Tumor / drug therapy. Ovarian Neoplasms / drug therapy. Peritoneal Neoplasms / secondary. Pleurisy / drug therapy. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Gastrectomy. Humans. Hysterectomy. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis. Methotrexate / administration & dosage. Neoplasms, Multiple Primary / drug therapy. Neoplasms, Multiple Primary / surgery. Pancreatectomy. Survivors

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  • (PMID = 17108732.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; YL5FZ2Y5U1 / Methotrexate
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52. Oh SC, Yoon SY, Seo JH, Choi CW, Kim BS, Shin SW, Kim YH, Kim SY, Yoon HJ, Cho KS, Kim JS: Pilot Study of Heptaplatin, UFT-E and Leucovorin in Advanced Gastric Carcinoma. Cancer Res Treat; 2003 Apr;35(2):117-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pilot Study of Heptaplatin, UFT-E and Leucovorin in Advanced Gastric Carcinoma.
  • PURPOSE: Heptaplatin (SKI-2053R, Sunpla ), a new platinum analogue which has a better toxicity profile than cisplatin, has been used with 5-fluorouracil (5-FU) continuous infusion for the treatment of advanced gastric carcinoma.
  • The aim of this study was to evaluate the efficacy and toxicity of heptaplatin, UFT-E and leucovorin combination chemotherapy in advanced gastric cancer.
  • Oral UFT-E 360 mg/m2 and leucovorin 45 mg/day were administered for 21 consecutive days followed by a 7-day drug free interval.
  • RESULTS: The 22 enrolled patients received 81 courses of chemotherapy and the median number of course per patient was three with a range of one to six.
  • Out of the 5 responding patients, three had unresectable perigastric lymph-nodes, one patient had a ovarian metastasis, and one patient had a peritoneal metastasis respectively.
  • The median time to progression was 4 months (range, 0.5 to 13 months), and median survival duration was 7.5 months (range, 2.0 to 14 months).
  • CONCLUSION: A combination chemotherapy of heptaplatin, UFT-E and leucovorin has a comparable efficacy with those of previously reported heptaplatin and intravenous regimen of 5-FU and controllable toxicity in advanced gastric carcinoma.

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  • (PMID = 26680924.001).
  • [ISSN] 1598-2998
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Keywords] NOTNLM ; Heptaplatin / Stomach neoplasm / UFT-E
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53. Cheong JH, Hyung WJ, Chen J, Kim J, Choi SH, Noh SH: Survival benefit of metastasectomy for Krukenberg tumors from gastric cancer. Gynecol Oncol; 2004 Aug;94(2):477-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival benefit of metastasectomy for Krukenberg tumors from gastric cancer.
  • OBJECTIVE: An optimal treatment strategy for ovarian metastases of gastric cancer has not been clearly established.
  • The aim of this study was to examine the role of a metastasectomy in the management of metachronous Krukenberg tumors after curative surgery for gastric cancer.
  • METHODS: Among 1235 female patients who had undergone a curative gastric resection for stomach cancer between 1987 and 1998, 54 (4.4%) developed Krukenberg tumors as a first recurrence without evidence of a distant metastasis.
  • RESULTS: The clinicopathological features of Krukenberg tumors as well as those of the primary cancers in the two groups were similar.
  • All 33 patients in the resection group underwent subsequent adjuvant chemotherapy, including the 7 who received intraperitoneal chemotherapy.
  • The 21 patients in the non-resection group were managed by either systemic chemotherapy (n = 16) or supportive care (n = 5) alone.
  • The median survival time in the resection group was 17 months (95% confidence interval, 10-24 months), which was significantly longer than that in the non-resection group, 3 months (95% confidence interval, 2-4 months) (P < 0.001).
  • CONCLUSION: Our results suggest that a metastasectomy was associated with an improved survival in patients with metachronous Krukenberg tumors from gastric cancer.
  • These data offer a strong argument in favor of performing metastasectomy for Krukenberg tumors in the absence of an obvious distant metastasis.
  • [MeSH-major] Krukenberg Tumor / secondary. Krukenberg Tumor / surgery. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 15297191.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Minicozzi A, Borzellino G, Momo EN, Segattini C, Pitoni F, Steccanella F, De Manzoni G: [Treatment of the peritoneal carcinomatosis by cytoreductive surgery and intraperitoneal hyperthermic chemotherapy (IHPC): postoperative morbidity and mortality and short-term follow-up]. Ann Ital Chir; 2008 Jul-Aug;79(4):231-9
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  • [Title] [Treatment of the peritoneal carcinomatosis by cytoreductive surgery and intraperitoneal hyperthermic chemotherapy (IHPC): postoperative morbidity and mortality and short-term follow-up].
  • BACKGROUND: In order to treat the peritoneal carcinomatosis from abdominal neoplasms has been recently proposed complete peritonectomy associated with IntraPeritoneal Hyperthermic Chemotherapy (IHPC).
  • Primary tumor was ovarian carcinoma in ten patients: four cases presented peritoneal surface malignancies (PSM) after any time from hysteroadnexectomy related to primary tumor, six cases synchronous PSM.
  • Primary tumor was gastric cancer in seven patients: the peritoneal washing was positive in four cases and, during follow-up period after gastrectomy, other two cases presented PSM.
  • One patient was previously treated with ovariectomy for ovaric mass that resulted a Krukenberg's tumor of gastric cancer.
  • Primary tumor was pseudomixoma peritonei in four patients; cytoreductive surgery and IHPC was carried as first line therapy in only one patient.
  • Three patients were previously treated for colon carcinoma.
  • The drugs used were Mitomycin C (3.3 mg/m2/L) and Cisplatin (25 mg/m2/L).
  • RESULTS: The mean Peritoneal Cancer Index (PCI) was 14.
  • After a median follow-up of 8 months (range 2-34), 14 (58%) patients are alive and 13 are disease free.
  • CONCLUSIONS: Our experience is consistent with other studies for the high rate of postoperative morbidity associated with treatment, but we achieved best results on mortality and post-operative staying.
  • CRS associated with IHPC is a good therapeutic option especially in ovaric-related carcinosis and PMP.
  • It' s still debated whether it could be useful or not in colorectal related carcinosis, whereas there is a general agreement in the un uselessness of this technique in gastric cancer.
  • [MeSH-major] Carcinoma / secondary. Carcinoma / therapy. Chemotherapy, Cancer, Regional Perfusion. Hyperthermia, Induced. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / therapy
  • [MeSH-minor] Adult. Antibiotics, Antineoplastic / administration & dosage. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Cisplatin / administration & dosage. Cisplatin / therapeutic use. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Length of Stay. Male. Middle Aged. Mitomycin / administration & dosage. Mitomycin / therapeutic use. Peritoneum / surgery. Postoperative Complications. Time Factors. Treatment Outcome

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  • (PMID = 19093624.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin
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55. Giannakopoulos ChK, Kyriakidou GK, Toufexi GE: Palmar fasciitis and polyarthritis associated with secondary ovarian carcinoma. Case report. Eur J Gynaecol Oncol; 2005;26(3):339-41
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  • [Title] Palmar fasciitis and polyarthritis associated with secondary ovarian carcinoma. Case report.
  • Palmar fasciitis and a polyarthritis syndrome (PFPAS) is an uncommon paraneoplastic syndrome often associated with occult neoplasms, including ovarian and pancreatic carcinomas.
  • Twelve months after onset of the symptoms an ovarian and pancreatic adenocarcinoma was diagnosed synchronously.
  • The spread pattern and other features of the neoplasm indicate that it was a primary pancreatic cancer with ovarian metastasis.
  • Surgical excision of tumor and adjuvant chemotherapy caused remission of symptoms.
  • A literature review of PFPAS and secondary ovarian neoplasms with a pancreatic primary tumor is discussed.
  • [MeSH-major] Adenocarcinoma / secondary. Arthritis / etiology. Fasciitis / etiology. Ovarian Neoplasms / secondary. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Carboplatin / therapeutic use. Cyclophosphamide / therapeutic use. Female. Hand. Humans. Paraneoplastic Syndromes / etiology. Surgical Procedures, Operative. Treatment Outcome

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  • (PMID = 15991542.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
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56. Inoue Y, Toiyama Y, Yokoe T, Tanaka K, Miki C, Kusunoki M: Direct evidence that heterogeneity necessitates and limits the use of multidrug chemotherapy in colon cancer. Mol Med Rep; 2008 Jul-Aug;1(4):531-5
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  • [Title] Direct evidence that heterogeneity necessitates and limits the use of multidrug chemotherapy in colon cancer.
  • Considerable progress in the form of multidrug chemotherapy has recently been made in chemotherapy for the prolongation of survival in advanced colon cancer.
  • It is generally accepted that colon cancer is biologically heterogeneous for multiple properties, including sensitivity to chemotherapeutic agents and metastasis.
  • Although this partly explains the success of multidrug chemotherapy, there has been no direct evidence that multidrug regimens affect individual heterogenous cancer characteristics in colon cancer.
  • Here, we present a case of metachronous ovarian metastasis in a colon cancer patient with dissemination who underwent irinotecan-based followed by oxaliplatin-based chemotherapy.
  • We were able to obtain three samples from the patient, one of primary cancer and two of metastatic tumors from secondary surgery.
  • Of note, both chemoresistant and chemosensitive tumors were present in the patient at the same time.
  • To understand the influence of multidrugs on individual cancer characteristics, we examined differences in the molecular characteristics of the three samples using RT-PCR, focusing in particular on alterations in chemoresistant genes.
  • In shrunken peritoneal metastasis, we found a significant increase in the mRNA levels of an irinotecan-sensitive gene, although other molecular factors were resistant to both 5-FU and oxaliplatin.
  • We also confirmed that the recurrent ovarian tumor showed significant resistance to all three drugs: 5-FU, irinotecan and oxaliplatin.
  • These results suggest that the heterogeneity of colon cancer necessitates and limits the use of multidrug chemotherapy.

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  • (PMID = 21479445.001).
  • [ISSN] 1791-2997
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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57. Mrad K, Morice P, Fabre A, Pautier P, Lhommé C, Duvillard P, Sabourin JC: Krukenberg tumor: a clinico-pathological study of 15 cases. Ann Pathol; 2000 May;20(3):202-6
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  • [Title] Krukenberg tumor: a clinico-pathological study of 15 cases.
  • Krukenberg tumor clinically mimics primary ovarian cancer.
  • We report a series of 15 cases of Krukenberg tumor.
  • Most ovarian tumors (14/15) were bilateral.
  • A primary digestive tumor was diagnosed pre-operatively in 3 cases, per-operatively in 3 cases and post-operatively in 4 cases.
  • No primary tumor was identified in the 5 other cases.
  • Histological diagnosis of Krukenberg tumor is usually easy either on paraffin or frozen sections.
  • Two main histological types were found in our series : the classic form with sarcoma-like storiform tumoral stroma and an alternative cellular-acellular pattern.
  • Nor surgery, neither chemotherapy is efficient but bilateral oophorectomy should be proposed in post-menopausal women with gastric linitis removed surgically.
  • [MeSH-major] Breast Neoplasms / diagnosis. Colonic Neoplasms / diagnosis. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary. Stomach Neoplasms / diagnosis

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  • (PMID = 10891713.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] FRANCE
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58. Rabban JT, Barnes M, Chen LM, Powell CB, Crawford B, Zaloudek CJ: Ovarian pathology in risk-reducing salpingo-oophorectomies from women with BRCA mutations, emphasizing the differential diagnosis of occult primary and metastatic carcinoma. Am J Surg Pathol; 2009 Aug;33(8):1125-36
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  • [Title] Ovarian pathology in risk-reducing salpingo-oophorectomies from women with BRCA mutations, emphasizing the differential diagnosis of occult primary and metastatic carcinoma.
  • Risk-reducing salpingo-oophorectomy (RRSO) is an effective prophylactic procedure for women with mutations in BRCA1 or BRCA2 genes, both of which confer an increased lifetime risk for ovarian, tubal, peritoneal, and breast cancer.
  • In addition to lowering this risk, RRSO also offers the opportunity to detect occult early-stage fallopian tube or ovarian carcinoma.
  • The differential diagnosis of occult tubal/ovarian cancer includes a spectrum of benign tubal and ovarian alterations and also occult metastatic breast cancer, although only rare cases of the latter have been reported in RRSO.
  • Neoadjuvant breast cancer chemotherapy may contribute to diagnostic difficulty due to treatment-induced cytologic alterations.
  • With the aim of elucidating features which may help with differential diagnosis, this study reports the incidence and pathologic features of benign ovarian alterations, benign ovarian tumors, and occult primary and metastatic malignancies in prophylactic oophorectomies from 108 women with a BRCA mutation and from 35 women with other strong risk factors for hereditary breast/ovarian carcinoma.
  • We direct particular emphasis on morphologic features of primary ovarian lesions that may mimic occult metastatic breast cancer.
  • We also evaluate histologic alterations due to neoadjuvant breast cancer chemotherapy in the ovary and fallopian tube of patients who received such treatment immediately preceding RRSO.
  • Comparison is made to ovarian metastases of breast cancer in our hospital-based population of breast cancer patients, none of whom underwent RRSO.
  • Overall, 69% of RRSO patients had a personal history of breast cancer.
  • Neoadjuvant breast cancer chemotherapy was administered in 15%.
  • Occult primary carcinoma occurred in 7 (6.5%) BRCA patients (5 in fallopian tube, 1 in fallopian tube and ovary, 1 in ovary).
  • Ovarian metastasis of breast cancer occurred in 1 (1%) BRCA patient undergoing RRSO and in up to a similar proportion (0.8%) of the hospital-based population of breast cancer patients.
  • The metastasis in the RRSO patient was clinically occult, unilateral, 0.2 cm, and demonstrated mild atypia without mitoses.
  • Abundant foamy, vacuolated cytoplasm due to neoadjuvant chemotherapy exposure was notable.
  • In contrast, ovarian metastases in the non-RRSO population were all clinically detected, bilateral, large, and exhibited well-developed malignant cytologic features.
  • None of the normal cell types in the ovary or tube demonstrated any cytologic alterations in RRSO patients who received neoadjuvant chemotherapy.
  • The main morphologic mimics of metastasis with superimposed chemotherapy-induced alterations in RRSO were stromal hyperthecosis (n=8), nodular hyperthecosis (n=2), adrenal rests (n=3), hilus cell nodules (n=43), and hilus cell hyperplasia (n=4).
  • Occult primary ovarian carcinoma was reliably distinguished from ovarian metastases of breast cancer by WT-1+, p53+, mammaglobin-, GCDPF-immunoprofile.
  • These results demonstrate that evaluation of RRSO specimens requires awareness of a spectrum of ovarian lesions which may mimic occult primary or metastatic carcinoma; awareness of the masquerading effects of neoadjuvant chemotherapy; and awareness of the potential morphologic differences between occult metastatic breast cancer in RRSO and non-RRSO specimens.
  • [MeSH-major] Genes, BRCA1. Genes, BRCA2. Ovarian Neoplasms / genetics. Ovarian Neoplasms / pathology. Ovarian Neoplasms / prevention & control
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Breast Neoplasms / drug therapy. Diagnosis, Differential. Fallopian Tubes / surgery. Female. Genetic Predisposition to Disease. Humans. Mutation. Neoplasms, Multiple Primary / genetics. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / prevention & control. Ovariectomy. Ovary / drug effects. Ovary / pathology. Risk Factors






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