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1. Turgut M, Gökpinar D, Barutça S, Erkuş M: Lumbosacral metastatic extradural Merkel cell carcinoma causing nerve root compression--case report. Neurol Med Chir (Tokyo); 2002 Feb;42(2):78-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lumbosacral metastatic extradural Merkel cell carcinoma causing nerve root compression--case report.
  • A 63-year-old man presented with a rare metastatic Merkel cell carcinoma (MCC) involving the lumbosacral spine and causing nerve root compression.
  • Magnetic resonance (MR) imaging revealed an extradural soft tissue mass at the L5-S1 levels.
  • The tumor was subtotally removed and chemotherapy was administered, but he died of multiple metastases from the primary epigastric tumor.
  • Extradural MCC metastasis in the lumbosacral area should be considered in the differential diagnosis of radicular symptoms caused by disc herniation.
  • [MeSH-major] Abdominal Neoplasms / surgery. Carcinoma, Merkel Cell / secondary. Epidural Neoplasms / secondary. Nerve Compression Syndromes / surgery. Spinal Neoplasms / secondary. Spinal Nerve Roots / surgery
  • [MeSH-minor] Diagnosis, Differential. Humans. Laminectomy. Lumbar Vertebrae / pathology. Lumbar Vertebrae / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Sacrum / pathology. Sacrum / surgery

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  • (PMID = 11944594.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Boghossian V, Owen ID, Nuli B, Xiao PQ: Neuroendocrine (Merkel cell) carcinoma of the retroperitoneum with no identifiable primary site. World J Surg Oncol; 2007;5:117

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  • [Title] Neuroendocrine (Merkel cell) carcinoma of the retroperitoneum with no identifiable primary site.
  • BACKGROUND: Neuroendocrine carcinoma is an aggressive neoplasm that mainly affects elderly Caucasians and typically arises in sun-exposed areas of the skin.
  • CASE PRESENTATION: We report a case of an 81-year-old Caucasian male with neuroendocrine carcinoma, which initially presented as a large retroperitoneal mass.
  • Pathological and immunohistochemical analysis of the transabdominal CT-guided biopsy specimen revealed tissue consistent with neuroendocrine carcinoma.
  • This would be consistent with a presumptive diagnosis of primary nodal disease.
  • Since Merkel cell precursors have never been identified within lymph nodes, the latter theory seems more befitting.
  • CONCLUSION: Wide local excision of the primary tumor is the surgical treatment of choice for localized disease.
  • We propose that further studies are needed to elucidate the true efficacy of chemotherapy in conventional as well as unconventional patients with neuroendocrine carcinoma.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Carcinoma, Neuroendocrine / secondary. Lymph Nodes / pathology. Neoplasms, Unknown Primary / pathology. Retroperitoneal Neoplasms / secondary
  • [MeSH-minor] Aged, 80 and over. Biopsy, Needle. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Male. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 17949500.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2117014
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3. Vijay K, Venkateswaran K, Shetty AP, Rajasekaran S: Spinal extra-dural metastasis from Merkel cell carcinoma: a rare cause of paraplegia. Eur Spine J; 2008 Sep;17 Suppl 2:S267-70
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  • [Title] Spinal extra-dural metastasis from Merkel cell carcinoma: a rare cause of paraplegia.
  • We report a rare case of Merkel cell carcinoma with extra-dural spinal metastasis causing paraplegia.
  • MRI showed multiple epidural soft tissue masses causing neural compression.
  • A biopsy from the truncal skin lesion was diagnosed as Merkel cell carcinoma (MCC).
  • Histopathology of the epidural tumor was consistent with MCC and the diagnosis was confirmed by immuno-histochemistry staining for cytokeratin-20.
  • She was started on chemotherapy and radiotherapy.
  • One month after diagnosis she died due to extensive metastasis.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Epidural Space / pathology. Paraplegia / etiology. Skin Neoplasms / pathology. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy. Breast Neoplasms / secondary. Decompression, Surgical. Disease Progression. Fatal Outcome. Female. Humans. Keratin-20 / analysis. Keratin-20 / metabolism. Magnetic Resonance Imaging. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / therapy. Neurosurgical Procedures. Treatment Failure

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  • (PMID = 18057968.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-20
  • [Other-IDs] NLM/ PMC2525916
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4. Strasser H, Amann K, Schrott KM, Krause FS: Solitary metastasis of a Merkel cell tumor to the urinary bladder. Anticancer Res; 2008 Mar-Apr;28(2B):1361-4
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  • [Title] Solitary metastasis of a Merkel cell tumor to the urinary bladder.
  • The primary Merkel cell carcinoma, a neuroendocrine tumor, mostly appears on skin areas exposed to light.
  • Complete excision with a safety margin plus local lymphadenectomy is the basic therapy.
  • In cases of relapse or metastasis, surgical treatment is also the first choice.
  • Chemotherapy or radiotherapy are used only for a palliative purpose.
  • In urology, the Merkel cell tumor has been detected only sporadically, while infiltration of the bladder has been described in three cases worldwide.
  • We report the case of a patient with a single metastasis of a Merkel cell tumor in the urinary bladder, after excision of the femoral primary cancer two years earlier.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Skin Neoplasms / pathology. Urinary Bladder Neoplasms / secondary

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  • (PMID = 18505079.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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5. Yamana N, Sueyama H, Hamada M: Cardiac metastasis from Merkel cell skin carcinoma. Int J Clin Oncol; 2004 Jun;9(3):210-2
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  • [Title] Cardiac metastasis from Merkel cell skin carcinoma.
  • A 54-year-old woman presented with cardiac metastasis of a Merkel cell carcinoma.
  • Chemotherapy was not effective for the metastasis sites; therefore, radiotherapy was performed for the metastatic cardiac tumors, and it reduced the volume of the cardiac tumors.
  • Cardiac metastasis from Merkel cell carcinoma is rare.
  • Radiotherapy for metastatic cardiac tumors from Merkel cell carcinoma is useful as palliative treatment when the response to chemotherapy is poor.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Heart Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 15221609.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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6. Ponte P, Moniz JV, Farricha V, Weinholtz JB: Merkel cell carcinoma: an unusual indication for isolated limb perfusion. Dermatol Online J; 2008;14(7):6
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  • [Title] Merkel cell carcinoma: an unusual indication for isolated limb perfusion.
  • Isolated limb perfusion (ILP) is a surgical technique that enables the administration of high-dose chemotherapy while minimizing serious systemic side effects.
  • The clinical value and indications are well established for skin and soft tissue tumors on limbs.
  • For soft tissue tumors--sarcoma and osteosarcoma--it is useful as a palliative technique to reduce the tumoral mass.
  • Limb perfusion can also be an option in other tumors, such as advanced stage squamous cell carcinoma or Merkel cell carcinoma.
  • We present a case report of a 68-year-old man with Merkel cell carcinoma on the right tibiotarsical region, with in-transit metastasis throughout the whole lower limb.
  • Regional chemotherapy involving ILP with melphalan and tumor necrosis factor-alpha (TNFalpha) was performed in order to avoid amputation; the primary tumor was not excised.
  • The addition of TNFalpha to melphalan in ILP appears to produce greater efficacy in the treatment of patients with bulky tumors or a large number of in-transit metastases.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Merkel Cell / drug therapy. Carcinoma, Merkel Cell / secondary. Chemotherapy, Cancer, Regional Perfusion / methods. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Fatal Outcome. Follow-Up Studies. Humans. Immunohistochemistry. Limb Salvage / methods. Lower Extremity. Male. Melphalan / administration & dosage. Neoplasm Metastasis. Neoplasm Staging. Palliative Care / methods. Risk Assessment. Treatment Outcome. Tumor Necrosis Factor-alpha / administration & dosage

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  • (PMID = 18718190.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; Q41OR9510P / Melphalan
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7. Barkdull GC, Healy JF, Weisman RA: Intracranial spread of Merkel cell carcinoma through intact skull. Ann Otol Rhinol Laryngol; 2004 Sep;113(9):683-7
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  • [Title] Intracranial spread of Merkel cell carcinoma through intact skull.
  • We report an unusual case of Merkel cell carcinoma presenting as a frontal scalp mass with apparent invasion into underlying brain parenchyma through grossly intact calvaria.
  • Despite wide local excision, craniectomy, intracranial tumor resection, and postoperative adjuvant irradiation, widespread systemic metastases resistant to chemotherapy developed, and the patient died 9 months after surgery.
  • This case report confirms that Merkel cell carcinoma of the head and neck, already known to be an aggressive tumor, has the capacity for rapid intracranial extension.
  • We found contrast-enhanced magnetic resonance imaging to be superior to computed tomography for defining soft tissue extent and marrow space involvement within underlying bone.
  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma, Merkel Cell / secondary. Frontal Bone. Neoplastic Cells, Circulating. Scalp. Skin Neoplasms / diagnosis. Skull Neoplasms / secondary
  • [MeSH-minor] Bone Marrow Neoplasms / diagnosis. Bone Marrow Neoplasms / pathology. Bone Marrow Neoplasms / secondary. Bone Marrow Neoplasms / surgery. Cerebral Cortex / pathology. Cerebral Cortex / surgery. Chemotherapy, Adjuvant. Combined Modality Therapy. Craniotomy. Disease Progression. Dura Mater / pathology. Dura Mater / surgery. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / pathology. Meningeal Neoplasms / secondary. Meningeal Neoplasms / surgery. Middle Aged. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 15453522.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Chang DT, Mancuso AA, Riggs CE Jr, Mendenhall WM: Merkel cell carcinoma of the skin with leptomeningeal metastases. Am J Otolaryngol; 2005 May-Jun;26(3):210-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma of the skin with leptomeningeal metastases.
  • Merkel cell carcinoma is a rare skin tumor that is thought to arise from epithelial cells that have undergone neuroendocrine differentiation.
  • Optimal treatment is controversial but generally consists of surgery and adjuvant radiotherapy.
  • The role of chemotherapy is less defined.
  • This report documents the first known case of Merkel cell carcinoma with perineural spread to the central nervous system with leptomeningeal dissemination.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Meningeal Neoplasms / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Combined Modality Therapy. Disease Progression. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Middle Aged. Radiotherapy Dosage

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  • (PMID = 15858780.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Wobser M, Kürzinger N, Ugurel S, Bröcker EB, Becker JC: Therapy of metastasized Merkel cell carcinoma with liposomal doxorubicin in combination with radiotherapy. J Dtsch Dermatol Ges; 2009 Jun;7(6):521-5
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  • [Title] Therapy of metastasized Merkel cell carcinoma with liposomal doxorubicin in combination with radiotherapy.
  • BACKGROUND: Merkel cell carcinoma is a rare skin cancer of neuroendocrine origin, which is characterized by a high rate of recurrence, metastatic spread and mortality.
  • Because of its rarity, evidence-based therapeutic regimens are difficult to establish.
  • Merkel cell carcinoma is known to be both radio- and chemosensitive.
  • PATIENTS AND METHODS: We retrospectively evaluated five patients with metastatic Merkel cell carcinoma to see if liposomal doxorubicin (Caelyx) or Myocet) in combination with radiotherapy exhibited clinical anti-tumoral effects accompanied by acceptable side effects.
  • RESULTS: The outpatient chemotherapy regimen was tolerated without major side effects and produced good response rates.
  • Effects of therapy were usually seen in the first cycle of therapy but the responses were of short duration with an average interval of two months until progression.
  • CONCLUSIONS: As combined radiochemotherapy with liposomal doxorubicin is well tolerated even in older patients with other illnesses and can be given on an outpatient basis, it is an attractive option for metastatic Merkel cell carcinoma.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Doxorubicin / administration & dosage. Radiotherapy, Conformal / methods. Skin Neoplasms / secondary. Skin Neoplasms / therapy
  • [MeSH-minor] Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 19192166.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 80168379AG / Doxorubicin
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10. Wang W, Veness M: Metastatic Merkel cell carcinoma to the soft tissues of the lower back. Australas J Dermatol; 2004 Feb;45(1):38-41
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  • [Title] Metastatic Merkel cell carcinoma to the soft tissues of the lower back.
  • Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma.
  • It has a propensity for both locoregional and distant recurrence despite treatment.
  • At 14 months post surgery and adjuvant radiotherapy he developed an isolated deposit of metastatic MCC in the paraspinal soft tissues of his lower back.
  • This atypical site of metastatic disease was treated with radiotherapy and combination chemotherapy.
  • Treatment in such cases needs to be individualized.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Skin Neoplasms / pathology. Soft Tissue Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Back / pathology. Combined Modality Therapy. Forehead / pathology. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 14961907.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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11. Waldmann V, Goldschmidt H, Jäckel A, Deichmann M, Hegenbart U, Hartschuh W, Ho A, Näher H: Transient complete remission of metastasized Merkel cell carcinoma by high-dose polychemotherapy and autologous peripheral blood stem cell transplantation. Br J Dermatol; 2000 Oct;143(4):837-9
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  • [Title] Transient complete remission of metastasized Merkel cell carcinoma by high-dose polychemotherapy and autologous peripheral blood stem cell transplantation.
  • Merkel cell carcinoma (MCC) is a rare cutaneous tumour with neuroendocrine differentiation.
  • Chemotherapy has been performed with a variety of protocols based largely on agents active in small-cell lung cancer.
  • Owing to the rarity of MCC, there is no standard protocol for the treatment of metastatic disease.
  • After diagnosis of distant metastases, first-line polychemotherapy (cisplatin 80 mg m(-2), doxorubicin 50 mg m(-2), etoposide 300 mg m(-2) and bleomycin 30 mg) was administered four times at 3-weekly intervals and resulted in partial remission of metastases.
  • Subsequently, high-dose chemotherapy according to the PEI regimen (ifosfamide 12 g m(-2), carboplatin 900 mg m(-2) and etoposide 1500 mg m(-2)) was applied, followed by autologous blood stem cell transplantation (ABSCT).
  • High-dose chemotherapy might be a therapeutic option in chemosensitive metastatic MCC, and further evaluation is warranted.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Hematopoietic Stem Cell Transplantation. Skin Neoplasms
  • [MeSH-minor] Carboplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Follow-Up Studies. Humans. Ifosfamide / administration & dosage. Male. Middle Aged. Remission Induction

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  • (PMID = 11069467.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; UM20QQM95Y / Ifosfamide; ICE protocol 3
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12. Boyse K, Foley EH, Bradley V, Scarborough D: Merkel cell carcinoma: a case report with treatment summary and updates. Cutis; 2004 Dec;74(6):350-6
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  • [Title] Merkel cell carcinoma: a case report with treatment summary and updates.
  • Merkel cell carcinoma (MCC) is a rare primary cutaneous neoplasm known for its propensity to develop early regional and distant metastasis.
  • Because of its aggressive nature, MCC is often resistant to surgery, radiation, and chemotherapy regimens.
  • Standardized treatment patterns have not been established, and difficulty arises finding appropriate treatment for the elderly, who comprise the majority of patients with MCC.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Skin Neoplasms / pathology. Skin Neoplasms / therapy
  • [MeSH-minor] Aged. Aged, 80 and over. Bone Neoplasms / secondary. Bone Neoplasms / therapy. Combined Modality Therapy. Humans. Male. Palliative Care

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  • [CommentIn] Cutis. 2006 Feb;77(2):109-10; author reply 110 [16570674.001]
  • (PMID = 15663071.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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13. Krejčí K, Tichý T, Horák P, Ciferská H, Hajdúch M, Srovnal J, Trojanec R, Zezulová M, Zlevorová M, Kalinová L, Zadražil J: Merkel cell carcinoma of the gluteal region with ipsilateral metastasis into the pancreatic graft of a patient after combined kidney-pancreas transplantation. Onkologie; 2010;33(10):520-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma of the gluteal region with ipsilateral metastasis into the pancreatic graft of a patient after combined kidney-pancreas transplantation.
  • BACKGROUND: Merkel cell carcinoma (MCC) is a rare tumour of the skin that predominantly affects elderly or immunocompromised patients.
  • The malignant transformation of Merkel cells is currently considered to be related to an infection with Merkel cell polyomavirus.
  • CASE REPORT: We present the case of a 62-year-old man who developed a Merkel cell polyomavirus-positive MCC in a non-UV-exposed part of the right gluteal region 8 years after combined kidney-pancreas transplantation.
  • Despite adjustment of the immunosuppressive therapy with conversion to sirolimus, the tumour generalised and metastasised into the pancreatic graft, leading to its failure.
  • Subsequent chemotherapy did not affect the course of the disease, and the patient died 9 months after diagnosis.
  • Given the highly aggressive course of the disease in patients after organ transplantation, MCC therapy should be sufficiently aggressive from the time of diagnosis and should not be influenced by attempts to preserve graft function.
  • [MeSH-major] Carcinoma, Merkel Cell / etiology. Carcinoma, Merkel Cell / secondary. Kidney Transplantation / adverse effects. Skin Neoplasms / pathology. Skin Neoplasms / secondary

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20926899.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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14. Nemoto I, Sato-Matsumura KC, Fujita Y, Natsuga K, Ujiie H, Tomita Y, Kato N, Kondo M, Ohnishi K: Leukaemic dissemination of Merkel cell carcinoma in a patient with systemic lupus erythematosus. Clin Exp Dermatol; 2008 May;33(3):270-2
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  • [Title] Leukaemic dissemination of Merkel cell carcinoma in a patient with systemic lupus erythematosus.
  • We describe an unusual bone-marrow metastasis of Merkel cell carcinoma (MCC) arising in the right cheek of a 73-year-old woman with systemic lupus erythematosus (SLE) and Sjögren's syndrome, who had been treated with oral prednisolone and methotrexate for 10 years.
  • [MeSH-major] Bone Marrow Neoplasms / secondary. Carcinoma, Merkel Cell / secondary. Facial Neoplasms
  • [MeSH-minor] Aged. Bone Marrow Examination. Fatal Outcome. Female. Humans. Immunocompromised Host. Lupus Erythematosus, Systemic / complications. Lupus Erythematosus, Systemic / drug therapy. Lymphatic Metastasis. Sjogren's Syndrome / complications. Sjogren's Syndrome / drug therapy

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  • (PMID = 18093245.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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15. Patnaik AK, Post GS, Erlandson RA: Clinicopathologic and electron microscopic study of cutaneous neuroendocrine (Merkel cell) carcinoma in a cat with comparisons to human and canine tumors. Vet Pathol; 2001 Sep;38(5):553-6
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  • [Title] Clinicopathologic and electron microscopic study of cutaneous neuroendocrine (Merkel cell) carcinoma in a cat with comparisons to human and canine tumors.
  • Malignant neuroendocrine carcinoma of the skin (Merkel cell tumor) was diagnosed in an 18-year-old spayed female Maine Coon Cat.
  • The diagnosis was made on the basis of morphologic and electron microscopic findings.
  • The tumor's malignancy contrasted with the benign nature of Merkel cell tumors reported in dogs and was consistent with the malignancy of Merkel cell tumors reported in humans.
  • [MeSH-major] Carcinoma, Merkel Cell / veterinary. Cat Diseases / pathology. Neoplasm Recurrence, Local / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Cats. Diagnosis, Differential. Dogs. Fatal Outcome. Female. Humans. Immunohistochemistry / veterinary. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Lung Neoplasms / veterinary. Mediastinal Neoplasms / drug therapy. Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / veterinary. Microscopy, Electron / methods. Microscopy, Electron / veterinary

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  • (PMID = 11572564.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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16. Kirwan C, Carney D, O'Keefe M: Merkel cell carcinoma metastasis to the iris in a 23 year old female. Ir Med J; 2009 Feb;102(2):53-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma metastasis to the iris in a 23 year old female.
  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy which predominantly affects elderly caucasians.
  • Histological diagnosis can be difficult and electron microscopy or immunohistochemistry are frequently required in addition to light microscopy.
  • Management is stage dependant and frequently involves wide surgical excision with or without chemotherapy or radiation therapy.
  • Early diagnosis and complete surgical excision is associated with a favourable prognosis.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Iris / pathology. Iris Neoplasms / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Adult. Fatal Outcome. Female. Humans. Mydriatics. Neoplasm Recurrence, Local / radiotherapy. Scalp

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  • (PMID = 19405321.001).
  • [ISSN] 0332-3102
  • [Journal-full-title] Irish medical journal
  • [ISO-abbreviation] Ir Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Mydriatics
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17. Stoll L, Mudali S, Ali SZ: Merkel cell carcinoma metastatic to the thyroid gland: Aspiration findings and differential diagnosis. Diagn Cytopathol; 2010 Oct;38(10):754-7
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  • [Title] Merkel cell carcinoma metastatic to the thyroid gland: Aspiration findings and differential diagnosis.
  • Herein, we report a case of metastatic Merkel cell carcinoma to the thyroid presenting as a 2.1-cm solid nodule in a 50-year-old male with a previous history of Merkel cell carcinoma of the upper extremity.
  • The differential diagnosis centered on the "small round blue cell" tumor group such as medullary thyroid carcinoma and non-Hodgkin lymphoma.
  • However, in light of our patient's previous history, the FNA findings were most consistent with a metastasis of Merkel cell carcinoma.
  • In patients with a known history of a primary neoplasm, the differential diagnosis of a thyroid nodule should always include potential metastasis.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Skin Neoplasms / pathology. Thyroid Neoplasms / secondary
  • [MeSH-minor] 6-Mercaptopurine / therapeutic use. Biopsy, Fine-Needle. Carcinoma, Small Cell / pathology. Crohn Disease / complications. Crohn Disease / drug therapy. Diagnosis, Differential. Fibrosis / complications. Humans. Immunosuppressive Agents / therapeutic use. Male. Middle Aged

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20082438.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; E7WED276I5 / 6-Mercaptopurine
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18. Lee WJ, Kim CH, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK: Cutaneous metastasis from large-cell neuroendocrine carcinoma of the urinary bladder expressing CK20 and TTF-1. Am J Dermatopathol; 2009 Apr;31(2):166-9
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  • [Title] Cutaneous metastasis from large-cell neuroendocrine carcinoma of the urinary bladder expressing CK20 and TTF-1.
  • Large-cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare.
  • The patient had been treated with partial cystectomy and chemotherapy for LCNEC of the urinary bladder, but a year later, he visited our clinic with a reddish mass on his scalp that was diagnosed as a cutaneous metastasis from LCNEC.
  • Most NECs, except for Merkel cell carcinomas, do not express CK20, whereas most urothelial carcinomas do express CK20.
  • These results suggest that a histogenetic link may exist between NEC of the urinary bladder and urothelial carcinoma.
  • [MeSH-major] Antibodies, Monoclonal / metabolism. Carcinoma, Large Cell / secondary. DNA-Binding Proteins / metabolism. Neuroendocrine Tumors / secondary. Skin Neoplasms / secondary. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Antibodies, Monoclonal, Murine-Derived. Biomarkers / metabolism. Biopsy. Fatal Outcome. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Rituximab. Scalp. Young Adult

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  • (PMID = 19318803.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers; 0 / DNA-Binding Proteins; 0 / TTF1 protein, human; 4F4X42SYQ6 / Rituximab
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19. Hassoun A, Ibrahim F: Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis. Am J Geriatr Pharmacother; 2007 Mar;5(1):48-51
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  • [Title] Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis.
  • BACKGROUND: Clostridium difficile is a gram-positive, anaerobic, spore-forming, rod-shaped bacterium responsible for most of the hospital-acquired diarrhea in developed countries.
  • He had had recent chemotherapy for Merkel cell carcinoma of the right ear.
  • Medical history included hypothyroidism for 10 years and non-Hodgkin's lymphoma in remission for 4 years after a stem cell transplant.
  • He had severe infection secondary to chemotherapy for Merkel cell carcinoma; in addition, he had failed to respond to metronida-zolc and vancomycin treatment, with the resulting development of colon dilatation and hypoalbuminemia.
  • At that point, the patient was given 1 dose of IV immunoglobulin (IVIG) 400 mg/kg; vancomycin treatment was continued.
  • Two days after IVIG therapy, the patient's diarrhea improved, with complete resolution after 6 days; bowel dilatation resolved completely after 7 days; and oral intake improved after 2 days.
  • Tissue culture assay is the best diagnostic test to detect the cytotoxin; enzyme immunoassay is the test used in most hospitals, but it has a sensitivity of only -75%.
  • Treatment options remain limited to eradicate this serious infection.
  • Antibiotic therapy, infection control measures, and early diagnosis are essential components of successful outcome for this disease.
  • This patient's infection resolved with the addition of IVIG with no recurrence, suggesting the possible benefit of this treatment in certain patients with severe colitis who do not respond to standard therapy.
  • [MeSH-major] Clostridium difficile / drug effects. Enterocolitis, Pseudomembranous / drug therapy. Immunoglobulins, Intravenous / therapeutic use. Immunologic Factors / therapeutic use
  • [MeSH-minor] Aged. Anti-Bacterial Agents / administration & dosage. Anti-Bacterial Agents / therapeutic use. Carcinoma, Merkel Cell / complications. Cytotoxins / analysis. Diarrhea / drug therapy. Ear Neoplasms / complications. Esomeprazole. Humans. Levofloxacin. Male. Metronidazole / therapeutic use. Ofloxacin. Skin Neoplasms / complications. Thyroxine. Vancomycin / administration & dosage. Vancomycin / therapeutic use

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  • (PMID = 17608247.001).
  • [ISSN] 1543-5946
  • [Journal-full-title] The American journal of geriatric pharmacotherapy
  • [ISO-abbreviation] Am J Geriatr Pharmacother
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Cytotoxins; 0 / Immunoglobulins, Intravenous; 0 / Immunologic Factors; 140QMO216E / Metronidazole; 6GNT3Y5LMF / Levofloxacin; 6Q205EH1VU / Vancomycin; A4P49JAZ9H / Ofloxacin; N3PA6559FT / Esomeprazole; Q51BO43MG4 / Thyroxine
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20. Lenormand C, Pelletier C, Goeldel AL, Chenard MP, Grange F: Second malignant neoplasm occurring years after hyperthermic isolated limb perfusion for melanoma. Arch Dermatol; 2010 Mar;146(3):319-21
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  • BACKGROUND: Hyperthermic isolated limb perfusion (HILP) is a useful therapeutic option in patients with locally advanced melanoma of the extremities.
  • Because HILP allows very high doses of cytotoxic agents to be administered without systemic leakage, the theoretical risk of a secondary malignant neoplasm is real, particularly in the treated limb.
  • OBSERVATIONS: We describe 2 cases of secondary rare cancers in 2 elderly women: 1 fatal pleomorphic sarcoma and 1 Merkel cell carcinoma, which developed on the same limb 16 years after HILP for melanoma.
  • CONCLUSIONS: Because long-term survivors of regionally advanced melanoma, although rare, do exist, candidates for HILP should be warned of the risk of long-term development of nonmelanoma secondary cancers.
  • The risk-benefit balance of high-dose local chemotherapy should be carefully evaluated in the light of these findings, especially in patients with early-stage melanoma or other non-life-threatening medical conditions.
  • [MeSH-major] Carcinoma, Merkel Cell / etiology. Hyperthermia, Induced / adverse effects. Melanoma / therapy. Neoplasms, Second Primary / etiology. Perfusion / adverse effects. Sarcoma / etiology. Skin Neoplasms / etiology
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Fatal Outcome. Female. Follow-Up Studies. Humans. Middle Aged. Time Factors

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  • (PMID = 20231505.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Tijink BM, De Bree R, Van Dongen GA, Leemans CR: How we do it: Chemo-electroporation in the head and neck for otherwise untreatable patients. Clin Otolaryngol; 2006 Oct;31(5):447-51
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  • Keypoints * Chemo-electroporation therapy with bleomycin is a locoregional treatment modality for head and neck and skin cancer, with the potential to preserve function.
  • * In our institution, chemo-electroporation therapy is used for patients that can no longer be treated by surgery or radiotherapy, or for whom surgical treatment would be very extensive and thus declined by the patient.
  • * This paper describes in detail the technique of bleomycin-electroporation therapy.
  • * The main focus of the trial is to determine the safety, effectiveness, and burden of bleomycin-electroporation therapy for the patient.
  • * All 17 tumours responded to therapy.
  • * Based on the outcome of the clinical trial, bleomycin-electroporation therapy has the potential to become a valuable addition to the late-stage treatment options for patients with head and neck or skin tumours.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Electroporation / methods. Head and Neck Neoplasms / therapy
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / secondary. Carcinoma, Basal Cell / therapy. Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Melanoma / secondary. Melanoma / therapy. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Netherlands. Salivary Gland Neoplasms / secondary. Salivary Gland Neoplasms / therapy. Sarcoma / secondary. Sarcoma / therapy. Skin Neoplasms / secondary. Skin Neoplasms / therapy. Treatment Outcome. Tumor Burden / drug effects

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  • (PMID = 17014460.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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22. Fiorillo JA: Merkel cell carcinoma metastatic to the heart. J Clin Oncol; 2008 Jul 20;26(21):3643-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma metastatic to the heart.
  • [MeSH-major] Carcinoma, Merkel Cell / secondary. Heart Neoplasms / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Chronic Disease. Diabetes Mellitus, Type 2 / complications. Humans. Hypertension / complications. Kidney Diseases / complications. Magnetic Resonance Imaging. Male. Multiple Myeloma / complications. Multiple Myeloma / drug therapy. Neoplasm Recurrence, Local / pathology. Sleep Apnea, Obstructive / complications. Tomography, X-Ray Computed. Venous Thrombosis / complications

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  • (PMID = 18640944.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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