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Items 1 to 27 of about 27
1. Sayed-Ahmed MM: Role of carnitine in cancer chemotherapy-induced multiple organ toxicity. Saudi Pharm J; 2010 Oct;18(4):195-206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of carnitine in cancer chemotherapy-induced multiple organ toxicity.
  • In the last few years, cancer chemotherapy has been successfully employed in the treatment of different types of human tumours.
  • Unfortunately, the optimal clinical usefulness of this important treatment modality is usually limited secondary to the development of life-threatening multiple organ toxicity.
  • Cancer chemotherapy may cause these toxic effects by mechanisms not involved in their anticancer activity that can severely affect the life of patients and represent a direct cause of death.
  • Several experimental and clinical studies have demonstrated that some important anticancer drugs interfere with the absorption, synthesis, and excretion of carnitine in non-tumour tissues, resulting in a secondary carnitine deficiency which is reversed by carnitine treatment without affecting anticancer therapeutic efficacy.
  • Prototypes of anticancer drugs that alter carnitine system are doxorubicin, cisplatin, carboplatin, oxaliplatin, cyclophosphamide and ifosfamide.
  • Furthermore, cachectic cancer patients are especially at risk for carnitine deficiency due to decreased oral intake and/or increased renal losses.
  • Altered serum and urine carnitine levels have been reported in cancer patients with various forms of malignant diseases.
  • Similarly, inhibition of gene expression of heart fatty acid-binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model has been reported.
  • In view of these facts and in view of irreplaceability of these important anticancer drugs, this review aimed to highlight the role of carnitine depletion and supplementation during development of chemotherapy-induced multiple organ toxicity.

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  • (PMID = 23960728.001).
  • [ISSN] 1319-0164
  • [Journal-full-title] Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  • [ISO-abbreviation] Saudi Pharm J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3730973
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2. Kitamura M, Wada N, Nagata S, Iizuka N, Jin YF, Tomoeda M, Yuki M, Naka N, Araki N, Yutani C, Tomita Y: Malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart: a case report. Diagn Pathol; 2010;5:2
Genetic Alliance. consumer health - Malignant peripheral nerve sheath tumor.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart: a case report.
  • A rare case is presented of a 61-year-old man with a malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart.
  • The primary tumor originated in the right thigh in 1982.
  • Since then, the patient has had repeated local recurrences in spite of repeated surgical treatment and adjuvant chemotherapy.
  • He has developed previous metastases of the lung and heart.
  • The patient died of cardiac involvement.
  • [MeSH-major] Heart Neoplasms / secondary. Nerve Sheath Neoplasms / secondary. Neurofibromatosis 1 / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Amputation. Autopsy. Biopsy. Chemotherapy, Adjuvant. Fatal Outcome. Humans. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Thigh. Treatment Outcome


3. Karpuz V, Ikitimur B, Karpuz H: [A survey of heart tumors: clinical and echocardiographic approach]. Anadolu Kardiyol Derg; 2007 Dec;7(4):427-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A survey of heart tumors: clinical and echocardiographic approach].
  • Heart tumors can be primary in origin, can develop from direct extension of a neighboring tumor or they can be the manifestation of metastasis of a distant tumor.
  • Myxomas are the most frequently encountered primary benign cardiac tumors.
  • Primary malignant tumors of the heart are rare, and they are mostly sarcomatous in structure.
  • Secondary heart tumors constitute a wide spectrum, nevertheless they most frequently originate from lung cancer, breast cancer and hematological malignancies.
  • Heart tumors may involve myocardium, endocardium, epicardium, pericardium, or any combination of the aforementioned layers.
  • On the other hand, the usual site for metastasis to the heart is the pericardium.
  • Magnetic resonance imaging and computerized tomography may be helpful for selected cases.
  • Surgery is the principal therapeutic option in benign tumors and when recurrences are not taken into account, they have favorable prognoses.
  • Since surgical resection is usually incomplete in malignant tumors, therapy must be individualized for each patient; even with adjuvant chemotherapy, postoperative survival is usually short.
  • Metastases to the heart are usually approached symptomatically except for exceptional cases.
  • [MeSH-major] Heart Neoplasms / diagnosis
  • [MeSH-minor] Echocardiography, Transesophageal. Fibroma / diagnosis. Fibroma / pathology. Fibroma / radiography. Fibroma / ultrasonography. Hemangioma / diagnosis. Hemangioma / pathology. Hemangioma / radiography. Hemangioma / ultrasonography. Humans. Magnetic Resonance Imaging. Myoma / diagnosis. Myoma / pathology. Myoma / radiography. Myoma / ultrasonography. Myxoma / diagnosis. Myxoma / pathology. Myxoma / radiography. Myxoma / ultrasonography. Tomography, X-Ray Computed

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  • (PMID = 18065342.001).
  • [ISSN] 1308-0032
  • [Journal-full-title] Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
  • [ISO-abbreviation] Anadolu Kardiyol Derg
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 49
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4. Szmit S, Zagrodzka M, Kurzyna M, Opolski G, Szczylik C: Sunitinib malate, a receptor tyrosine kinase inhibitor, is effective in the treatment of restrictive heart failure due to heart metastases from renal cell carcinoma. Cardiology; 2009;114(1):67-71
MedlinePlus Health Information. consumer health - Heart Failure.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sunitinib malate, a receptor tyrosine kinase inhibitor, is effective in the treatment of restrictive heart failure due to heart metastases from renal cell carcinoma.
  • Few systematic trials have studied metastatic tumors to the heart and there are currently no guidelines for the treatment of heart metastases and its associated symptoms.
  • This article presents the first known case of effective pharmacological treatment of heart failure due to metastases of renal cell carcinoma (RCC).
  • Due to pressure caused by metastatic tissue on the left atrium and the decreased blood inflow to the left ventricle, the 61-year-old male patient suffered from dyspnea.
  • Treatment with sunitinib, an oral multitargeted receptor tyrosine kinase inhibitor, was initiated and led to a decrease in the mass of the metastasis infiltrating the left atrium.
  • Arterial hypertension caused by sunitinib therapy was effectively controlled by the use of an angiotensin-converting-enzyme inhibitor.
  • Therapy with sunitinib reduced the symptoms of exercise intolerance; the patient felt much better and was able to return to his family and resume professional activity.
  • Further studies are required to confirm the utility of sunitinib therapy in patients with symptoms of heart failure due to heart metastases from RCC.
  • [MeSH-major] Angiogenesis Inhibitors / administration & dosage. Heart Failure / drug therapy. Indoles / administration & dosage. Protein-Tyrosine Kinases / administration & dosage. Pyrroles / administration & dosage
  • [MeSH-minor] Carcinoma, Renal Cell. Echocardiography. Heart Neoplasms / complications. Heart Neoplasms / secondary. Humans. Male. Middle Aged. Poland. Treatment Outcome

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19372677.001).
  • [ISSN] 1421-9751
  • [Journal-full-title] Cardiology
  • [ISO-abbreviation] Cardiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Indoles; 0 / Pyrroles; 0 / sunitinib; EC 2.7.10.1 / Protein-Tyrosine Kinases
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5. Debourdeau P, Gligorov J, Teixeira L, Aletti M, Zammit C: [Malignant cardiac tumors]. Bull Cancer; 2004 Nov;91 Suppl 3:136-46

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant cardiac tumors].
  • [Transliterated title] Tumeurs cardiaques malignes.
  • Cardiac neoplasms are a rare occurrence in clinical practice.
  • The various frequencies of primary and secondary malignant tumors vary from report to report, approximately 1% in most autopsy series and 4% in cancer patient's autopsies.
  • Cardiac malignancies account for less 1% of cardiac surgery and about for 0.1% of cardiac echographic studies.
  • The presence of metastatic tumor to the heart usually indicates widespread metastases.
  • Lung carcinomas are the most commonly encountered tumor followed by breast and pancreas cancer and melanoma.
  • Apart from primary pericardial mesothelioma, primary cardiac tumors are high-grade sarcomas with a high metastatic potency that often becomes evident early after surgery.
  • Symptoms are non specific, occur late in the disease and affect few patients; especially secondary neoplasms of the heart take their course so fast that they cannot become symptomatic.
  • The signs of cardiac neoplasms are divided into systemic symptoms (fever, arthralgias and myalgias), cardiac symptoms (congestive heart failure, arrhythmia, chest pain) and uncommon embolisms.
  • Diagnosis is actually made easier with cardiac echography.
  • Cardiac RMI is helpful to estimate vessels and pericardium involvement.
  • Due to its poor prognosis, treatment of cardiac metastases is restricted to best supportive care.
  • For primary cardiac neoplasms, surgery must be carefully discussed because operative intervention is often followed by rapid widespread metastases that adjuvant chemotherapy cannot avoid in most cases.
  • [MeSH-major] Heart Neoplasms

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  • (PMID = 15899620.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 53
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6. Orcurto MV, Delaloye AB, Letovanec I, Martins Favre M, Prior JO: Detection of an asymptomatic right-ventricle cardiac metastasis from a small-cell lung cancer by F-18-FDG PET/CT. J Thorac Oncol; 2009 Jan;4(1):127-30
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of an asymptomatic right-ventricle cardiac metastasis from a small-cell lung cancer by F-18-FDG PET/CT.
  • A right heart metastasis of a small-cell lung cancer was found on the whole-body F-fluoro-deoxy-glucose positron emission tomography/computed tomography (F-FDG-PET/CT) of a 69-year-old smoker investigated for a right pulmonary mass discovered on chest radiography after a fracture of the right humerus.
  • CT-guided lung biopsy revealed a small-cell lung cancer and myocardial biopsy confirmed the presence of a cardiac metastasis.
  • The patient was treated with six cycles of chemotherapy followed by radiation therapy, which included the heart lesion.
  • At follow-up PET/CT 2 months after the end of treatment, the abnormal cardiac uptake had disappeared, whereas increased FDG uptake persisted in the pulmonary residual mass.
  • [MeSH-major] Heart Neoplasms / radionuclide imaging. Heart Ventricles / pathology. Lung Neoplasms / radionuclide imaging. Positron-Emission Tomography. Small Cell Lung Carcinoma / radionuclide imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Fatal Outcome. Fluorodeoxyglucose F18. Humans. Male. Radiopharmaceuticals

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  • (PMID = 19096320.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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7. Uzun O, Wilson DG, Vujanic GM, Parsons JM, De Giovanni JV: Cardiac tumours in children. Orphanet J Rare Dis; 2007;2:11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac tumours in children.
  • Cardiac tumours are benign or malignant neoplasms arising primarily in the inner lining, muscle layer, or the surrounding pericardium of the heart.
  • They can be primary or metastatic.
  • Primary cardiac tumours are rare in paediatric practice with a prevalence of 0.0017 to 0.28 in autopsy series.
  • In contrast, the incidence of cardiac tumours during foetal life has been reported to be approximately 0.14%.
  • The vast majority of primary cardiac tumours in children are benign, whilst approximately 10% are malignant.
  • Secondary malignant tumours are 10-20 times more prevalent than primary malignant tumours.
  • Rhabdomyoma is the most common cardiac tumour during foetal life and childhood.
  • It accounts for more than 60% of all primary cardiac tumours.
  • The frequency and type of cardiac tumours in adults differ from those in children with 75% being benign and 25% being malignant.
  • Sarcomas make up 75% of malignant cardiac masses.
  • Echocardiography, Computing Tomography (CT) and Magnetic Resonance Imaging (MRI) of the heart are the main non-invasive diagnostic tools.
  • Cardiac catheterisation is seldom necessary.
  • Tumour biopsy with histological assessment remains the gold standard for confirmation of the diagnosis.
  • Surgical resection of primary cardiac tumours should be considered to relieve symptoms and mechanical obstruction to blood flow.
  • The outcome of surgical resection in symptomatic, non-myxomatous benign cardiac tumours is favourable.
  • Patients with primary cardiac malignancies may benefit from palliative surgery but this approach should not be recommended for patients with metastatic cardiac tumours.
  • Surgery, chemotherapy and radiotherapy may prolong survival.
  • The prognosis for malignant primary cardiac tumours is generally extremely poor.
  • [MeSH-major] Heart Neoplasms / diagnosis. Heart Neoplasms / epidemiology
  • [MeSH-minor] Adult. Age Distribution. Child. Child, Preschool. Female. Fetal Diseases / diagnosis. Fetal Diseases / epidemiology. Fetal Diseases / therapy. Fibroma / diagnosis. Fibroma / epidemiology. Fibroma / therapy. Global Health. Heart Transplantation. Hemangioma / diagnosis. Hemangioma / epidemiology. Hemangioma / therapy. Humans. Infant. Infant, Newborn. Male. Myxoma / diagnosis. Myxoma / epidemiology. Myxoma / therapy. Pregnancy. Prenatal Diagnosis / methods. Prevalence. Rhabdomyoma / diagnosis. Rhabdomyoma / epidemiology. Rhabdomyoma / therapy. Teratoma / diagnosis. Teratoma / epidemiology. Teratoma / therapy

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  • [Cites] Am Heart J. 1979 May;97(5):639-43 [433739.001]
  • [Cites] J Med Soc N J. 1979 Mar;76(3):213-5 [286068.001]
  • [Cites] Acta Med Scand. 1979;206(1-2):115-21 [484252.001]
  • [Cites] Pathol Annu. 1979;14 Pt 2:325-55 [232754.001]
  • [Cites] Hum Pathol. 1980 Nov;11(6):598-605 [6778813.001]
  • [Cites] Cancer. 1982 Jan 15;49(2):398-402 [7053836.001]
  • [Cites] J Thorac Cardiovasc Surg. 1982 Mar;83(3):339-48 [7062746.001]
  • [Cites] Hum Pathol. 1993 Nov;24(11):1226-31 [8244322.001]
  • [Cites] Ann Thorac Surg. 1994 Aug;58(2):483-7; discussion 487-8 [8067852.001]
  • [Cites] Am Heart J. 1994 Nov;128(5):1009-21 [7942464.001]
  • [Cites] Ultrasound Obstet Gynecol. 1996 Jan;7(1):84-5 [8932639.001]
  • [Cites] Heart. 1997 Apr;77(4):388 [9155628.001]
  • [Cites] Am J Cardiol. 1997 Sep 1;80(5):671-82 [9295010.001]
  • [Cites] Am Heart J. 1997 Dec;134(6):1107-14 [9424072.001]
  • [Cites] Arch Dis Child. 1998 Feb;78(2):159-62 [9579160.001]
  • [Cites] Ann Thorac Surg. 1998 May;65(5):1388-90 [9594871.001]
  • [Cites] J Child Neurol. 1998 Dec;13(12):624-8 [9881533.001]
  • [Cites] Cancer. 1999 Jan 1;85(1):78-84 [9921977.001]
  • [Cites] Ultrasound Obstet Gynecol. 1999 May;13(5):363-5 [10380304.001]
  • [Cites] Circulation. 1962 Aug;26:228-41 [14037856.001]
  • [Cites] Chest. 1982 Apr;81(4):511-2 [7067518.001]
  • [Cites] J Am Coll Cardiol. 1984 Mar;3(3):827-32 [6693654.001]
  • [Cites] J Am Coll Cardiol. 1984 Mar;3(3):868-71 [6693658.001]
  • [Cites] J Thorac Cardiovasc Surg. 1984 May;87(5):725-31 [6717050.001]
  • [Cites] Cancer. 1985 Aug 15;56(4):825-36 [4016674.001]
  • [Cites] Mayo Clin Proc. 1986 Mar;61(3):165-72 [3945116.001]
  • [Cites] Circulation. 1987 Apr;75(4):705-10 [3829332.001]
  • [Cites] J Thorac Cardiovasc Surg. 1987 Apr;93(4):502-11 [3560997.001]
  • [Cites] Am Heart J. 1987 Oct;114(4 Pt 1):782-92 [3310564.001]
  • [Cites] Hum Pathol. 1988 Nov;19(11):1361-2 [3181957.001]
  • [Cites] Am J Cardiol. 1989 Apr 15;63(13):1006-8 [2929455.001]
  • [Cites] Am J Pediatr Hematol Oncol. 1989 Fall;11(3):343-7 [2782566.001]
  • [Cites] Ann Thorac Surg. 1990 Apr;49(4):612-7; discussion 617-8 [2322057.001]
  • [Cites] Ann Thorac Surg. 1990 Oct;50(4):557-61 [2222043.001]
  • [Cites] Am J Cardiol. 1990 Nov 15;66(17):1247-9 [2239731.001]
  • [Cites] Am J Med Genet. 1990 Dec;37(4):443-6 [2260584.001]
  • [Cites] Ann N Y Acad Sci. 1991;615:50-7 [2039167.001]
  • [Cites] Am J Cardiovasc Pathol. 1990;3(3):195-8 [2095826.001]
  • [Cites] Am J Cardiovasc Pathol. 1990;3(4):283-90 [2129569.001]
  • [Cites] Am J Cardiol. 1992 Jan 15;69(3):283-5 [1731477.001]
  • [Cites] J Thorac Cardiovasc Surg. 1992 Apr;103(4):655-64 [1548908.001]
  • [Cites] Obstet Gynecol. 1992 May;79(5 ( Pt 2)):856-9 [1565387.001]
  • [Cites] Am J Cardiovasc Pathol. 1992;4(1):85-90 [1627332.001]
  • [Cites] Arch Mal Coeur Vaiss. 1992 May;85(5):603-8 [1530401.001]
  • [Cites] Cancer. 1992 Oct 15;70(8):2203-7 [1394052.001]
  • [Cites] Arch Dis Child. 1992 Oct;67(10 Spec No):1189-92 [1444556.001]
  • [Cites] Arch Dis Child. 1993 Mar;68(3):367-70 [8466239.001]
  • [Cites] Arch Pathol Lab Med. 1993 Oct;117(10):1027-31 [8215825.001]
  • [Cites] Tex Heart Inst J. 1993;20(3):231-4 [8219827.001]
  • [Cites] Pediatr Radiol. 1993;23(5):384-5 [8233695.001]
  • [Cites] J Paediatr Child Health. 2000 Feb;36(1):84-6 [10723700.001]
  • [Cites] J Thorac Cardiovasc Surg. 1994 Nov;108(5):862-70 [7967668.001]
  • [Cites] Pediatr Pathol. 1994 Nov-Dec;14(6):913-7 [7855010.001]
  • [Cites] Am J Med Genet. 1994 Nov 1;53(2):141-8 [7856638.001]
  • [Cites] Ann Surg. 1995 Apr;221(4):415-9 [7726678.001]
  • [Cites] J Am Coll Cardiol. 1995 Aug;26(2):516-20 [7608458.001]
  • [Cites] Am J Cardiol. 1995 Aug 15;76(5):419-21 [7639176.001]
  • [Cites] N Engl J Med. 1995 Dec 14;333(24):1610-7 [7477198.001]
  • [Cites] Ann Thorac Surg. 1996 Aug;62(2):559-64 [8694623.001]
  • [Cites] Heart. 1996 Aug;76(2):188 [8795490.001]
  • [Cites] Acta Paediatr. 1996 Aug;85(8):928-31 [8863873.001]
  • [Cites] Cardiovasc Pathol. 2000 Jan-Feb;9(1):55-7 [10739909.001]
  • [Cites] Pediatr Cardiol. 2000 Jul-Aug;21(4):317-23 [10865004.001]
  • [Cites] Heart. 2001 Feb;85(2):218-22 [11156679.001]
  • [Cites] Pathology. 2001 May;33(2):230-4 [11358060.001]
  • [Cites] Cell Signal. 2003 Aug;15(8):729-39 [12781866.001]
  • [Cites] Pediatr Cardiol. 2004 May-Jun;25(3):252-73 [15360117.001]
  • [Cites] Circulation. 1967 Sep;36(3):427-40 [6033170.001]
  • [Cites] Am J Cardiol. 1968 Mar;21(3):363-6 [4866645.001]
  • [Cites] Am J Cardiol. 1968 Jul;22(1):85-107 [4873149.001]
  • [Cites] Arch Dis Child. 1971 Aug;46(248):508-14 [5565462.001]
  • [Cites] Arch Pathol. 1973 Jan;95(1):26-36 [4682025.001]
  • [Cites] Eur J Cardiol. 1975 Jun;3(1):71-3 [1132411.001]
  • [Cites] Am J Cardiol. 1976 Aug;38(2):241-51 [952267.001]
  • (PMID = 17331235.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 78
  • [Other-IDs] NLM/ PMC3225855
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8. Miller ES, Hoekstra AV, Hurteau JA, Rodriguez GC: Cardiac metastasis from poorly differentiated carcinoma of the cervix: a case report. J Reprod Med; 2010 Jan-Feb;55(1-2):78-80
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac metastasis from poorly differentiated carcinoma of the cervix: a case report.
  • BACKGROUND: Disease metastatic to the heart from cervical carcinoma is rare and associated with a poor prognosis.
  • Multimodality treatment has been shown to provide palliative benefit.
  • CASE: A woman presented with stage Ib2 cervical cancer metastatic to the tricuspid valve.
  • She presented with small bowel obstruction from a small bowel metastasis 4 years after initial treatment with chemoradiation.
  • Cardiac magnetic resonance imaging showed a tricuspid mass.
  • Endomyocardial biopsy confirmed metastatic disease consistent with a cervical primary.
  • The patient was treated with bowel resection, systemic chemotherapy and cardiac radiation.
  • She died of cardiac failure 8 months after diagnosis of the cardiac lesion.
  • CONCLUSION: Cervical cancer metastatic to the heart is rare and associated with a poor prognosis.
  • Selected patients may benefit from multimodality treatment.
  • [MeSH-major] Carcinoma / secondary. Heart Neoplasms / secondary. Tricuspid Valve / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Fatal Outcome. Female. Humans. Middle Aged

  • MedlinePlus Health Information. consumer health - Cervical Cancer.
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  • (PMID = 20337214.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Gacem K, Vachon L, Benard T, Delaire C, Bouvier JM: [Right atrioventricular metastasis of a myxoid liposarcoma. Case report and al review of the literature]. Arch Mal Coeur Vaiss; 2000 Sep;93(9):1155-8
Genetic Alliance. consumer health - Myxoid liposarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Right atrioventricular metastasis of a myxoid liposarcoma. Case report and al review of the literature].
  • Malignant tumours of the heart and pericardium are rare.
  • Secondary tumours are 20 to 40 times more common than primary tumours.
  • The authors report the case of a cardiac metastasis of a myxoid liposarcoma of the inguinal region.
  • Surgical ablation with chemotherapy significantly improved the patient' clinical and haemodynamic status.
  • A review of the literature shows that postoperative survival does not exceed 2 years, but the prognosis is better when chemotherapy is associated with surgery.
  • It provides a better evaluation of the tumour and its location, compared to thoracic CT scan and transthoracic echocardiography.
  • [MeSH-major] Abdominal Neoplasms / pathology. Heart Neoplasms / secondary. Liposarcoma, Myxoid / secondary

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  • (PMID = 11055008.001).
  • [ISSN] 0003-9683
  • [Journal-full-title] Archives des maladies du coeur et des vaisseaux
  • [ISO-abbreviation] Arch Mal Coeur Vaiss
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] FRANCE
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10. Bien E, Stachowicz-Stencel T, Balcerska A, Godzinski J, Kazanowska B, Perek-Polnik M, Madziara W, Rybczynska A, Kurylak A, Zalewska-Szewczyk B, Peregud-Pogorzelski J: Angiosarcoma in children - still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study. Eur J Cancer Care (Engl); 2009 Jul;18(4):411-20
MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The report of the Polish Paediatric Rare Tumours StudyAngiosarcoma is a rare, highly malignant vascular neoplasm with little data available on its clinical course and management in children.
  • Ten children with angiosarcoma (M/F: 6/4; aged 2, 3-16 years) registered in Polish Paediatric Rare Tumours and Soft Tissue Sarcomas Studies between 1992 and 2006.
  • Primary tumour exceeded 5 cm in seven patients and affected mainly deep tissues (heart-2, head/neck, bladder, brain, liver and upper limb - one patient each).
  • Four patients had regional and two metastatic diseases (lungs and bones).
  • All patients received supplementing chemotherapy with no response in four.
  • Three of five secondary tumour resections proved complete.
  • Seven patients experienced relapses (mainly metastatic) and two continuous progression.
  • Relapsed patients received chemotherapy +/- radiotherapy and surgery (three).
  • Nine patients died of disease (overall survival 6-66 months), and one child after mutilating secondary resection is alive.
  • The response to chemotherapy is poor and the large number of metastatic recurrences suggests a need for systemic therapy modifications.
  • [MeSH-major] Hemangiosarcoma / pathology. Hemangiosarcoma / therapy. Sarcoma / pathology. Sarcoma / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Child. Child, Preschool. Disease Progression. Humans. Male. Poland / epidemiology. Prognosis. Radiotherapy. Recurrence. Retrospective Studies. Survival Rate

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  • (PMID = 19490008.001).
  • [ISSN] 1365-2354
  • [Journal-full-title] European journal of cancer care
  • [ISO-abbreviation] Eur J Cancer Care (Engl)
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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11. Liassides C, Katsamaga M, Deretzi G, Koutsimanis V, Zacharakis G: Cerebral metastasis from heart angiosarcoma presenting as multiple hematomas. J Neuroimaging; 2004 Jan;14(1):71-3
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  • [Title] Cerebral metastasis from heart angiosarcoma presenting as multiple hematomas.
  • The authors present the case of a 24-year-old woman with cerebral metastasis from a primary heart angiosarcoma, which appeared as multiple cerebral hematomas.
  • Primary or metastatic brain angiosarcomas are exceedingly rare, and only a few cases have been reported with hemorrhage.
  • A computed tomography (CT) scan and magnetic resonance imaging showed 2 hematomas in the left parietal and occipital lobes.
  • A thoracic CT scan revealed angiosarcoma of the right atrium of the heart with multiple infiltrations of the lung.
  • The patient underwent surgical removal and systemic chemotherapy.
  • [MeSH-major] Brain Neoplasms / secondary. Cerebral Hemorrhage / etiology. Heart Neoplasms / pathology. Hemangiosarcoma / secondary. Hematoma / etiology
  • [MeSH-minor] Adult. Brain / pathology. Brain / radiography. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 14748213.001).
  • [ISSN] 1051-2284
  • [Journal-full-title] Journal of neuroimaging : official journal of the American Society of Neuroimaging
  • [ISO-abbreviation] J Neuroimaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Kisselbach C, Ristic AD, Pankuweit S, Karatolius K, Maisch B: [Women and pericardial neoplastic manifestations of the heart and pericardium]. Herz; 2005 Aug;30(5):409-15; quiz 429-30
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  • [Title] [Women and pericardial neoplastic manifestations of the heart and pericardium].
  • In the Western world more than 450,000 women succumb to heart disease annually.
  • Despite the proportions, most women believe that heart disease is a man's disease and that they will die of breast cancer.
  • Data on epidemiology and incidence are rare: there is only an estimated incidence of cardiac neoplasm at necropsy ranging from 0,001% to 0,3%.
  • The most common tumor entity is benign cardiac myxoma.
  • Malignant heart tumors are less common.
  • Most often they are different types of sarcomas, which have a poor outcome and affect more males than females.
  • Metastatic tumors of the heart are 100 times more common than the primary ones.
  • They originate mainly from melanomas, leukemias, lymphomas, and cancer, especially of the lung or breast.
  • Indeed in women breast cancer is the most common metastatic tumor associated with pericardial effusion.
  • To prevent death from tamponade, pericardiocentesis, in addition to the systemic chemotherapy, is mandatory, best when instillation of chemotherapeutics (cisplatin or thiotepa) or radioisotopes is given into the pericardial sac to prevent recurrence of the effusion.
  • However, more of the malignant tumors may be curable if exactly diagnosed at an earlier stage.
  • METHODS: A retrospective study was conducted of all patients with cardiac and pericardial neoplasm exactly diagnosed by endomyocardial or epicardial biopsy and pericardiocentesis, using hospital medical records and a biopsy and pericardiocentesis registry from 2000-2005 with 297 patients.
  • RESULTS: In 76 cases (25.6%) a neoplasm was the reason for a pericardial effusion.
  • 36 women suffered from the breast carcinoma (47%) and 40 males lung cancer (42%) as the firstly metastatic tumor.
  • CONCLUSION: Females are more often affected by primary cardiac tumors than males with an excellent outcome.
  • By contrast, the preventive checkup and aftercare will gain more prognostic importance, especially in case of breast cancer, to earlier recognize a secondary cardiac neoplasm by biopsy and pericardiocentesis with intrapericardial treatment of neoplastic pericarditis.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / secondary. Heart Neoplasms / epidemiology. Heart Neoplasms / secondary. Lung Neoplasms / epidemiology. Lung Neoplasms / secondary. Registries. Risk Assessment / methods

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  • (PMID = 16132244.001).
  • [ISSN] 0340-9937
  • [Journal-full-title] Herz
  • [ISO-abbreviation] Herz
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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13. Chrissos DN, Stougiannos PN, Mytas DZ, Katsaros AA, Andrikopoulos GK, Kallikazaros IE: Multiple cardiac metastases from a malignant melanoma. Eur J Echocardiogr; 2008 May;9(3):391-2
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  • [Title] Multiple cardiac metastases from a malignant melanoma.
  • Metastatic tumors in the pericardium or the heart are more common than primary tumors and their incidence has increased during the last decades due to the prolonged survival of patients with cancer and the increased prevalence of the disease in the general population.
  • He had a history of a malignant skin melanoma surgically removed 4 years ago.
  • The echo study identified multiple metastases in the heart involving the pericardium, the myocardium and the right atrium, where the tumor was mobile creating mechanical tricuspid valve stenosis.
  • Malignant metastasis was confirmed by pericardiocentesis and, although treatment with chemotherapy was promptly initiated, the patient died 4 months later.
  • Despite the difficulty in clinical diagnosis of cardiac melanoma, early detection has important therapeutic and prognostic implications.
  • Echocardiography is the most common diagnostic modality and transesophageal approach may be the technique of choice to image intracardiac metastatic tumors.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Melanoma / ultrasonography. Skin Neoplasms / pathology

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  • (PMID = 17347051.001).
  • [ISSN] 1532-2114
  • [Journal-full-title] European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
  • [ISO-abbreviation] Eur J Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Hughes DP, Crutchley M, Douglas WI, Munsell MF, Vaporciyan AA, Herzog C, Tsai FW, Huh W: Incidence, detection, and management of cardiac metastasis in pediatric sarcoma patients. J Clin Oncol; 2009 May 20;27(15_suppl):10060

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence, detection, and management of cardiac metastasis in pediatric sarcoma patients.
  • : 10060 Background: Sarcoma metastasizing to the heart is a difficult and complicated clinical problem, yet local control is feasible and effective for select patients with cardiac metastasis.
  • Diligence is required to detect these lesions while still amenable to treatment, and echocardiogram remains the best tool for detecting cardiac disease.
  • Anderson Cancer Center between 1997 and 2008.
  • Measures of cardiac function and pathology (including size of ventricles and atria, function of ventricles and valves, presence of metastasis, and presence of pericardial effusion) were assigned numerical values.
  • Fisher's exact test and the Wilcoxon rank-sum test compared clinical characteristics of patients with and without cardiac metastases.
  • RESULTS: The prevalence of cardiac metastases was 1.6% (5/307) with 95% confidence interval 0.5% to 3.8%.
  • The presence of cardiac metastasis positively correlated with pericardial effusion (p = 0.001) and tricuspid valve insufficiency (p = 0.014).
  • The probability of a patient with pericardial effusion having a cardiac metastasis was 28.6% (95% CI: 3.7%-71%).
  • Of the 5 patients with documented sarcoma metastasis to the heart, 3 had widespread refractory disease, were given no cardiac-specific therapy, and rapidly died from disease.
  • One patient who had widespread disease controlled with chemotherapy and radiation had open resection of 2 cardiac metastases which resulted in site-specific disease control for 6 months before succumbing to progressive extra-cardiac disease.
  • Another patient had isolated cardiac metastasis, treated with open resection of 2 metastases followed by adjuvant chemotherapy, and has been without recurrent cardiac metastases for 5 years and 9 months.
  • CONCLUSIONS: Durable local control for sarcoma metastasizing to the heart is possible and effective for select patients.
  • Pericardial effusion merits evaluation for potential associated cardiac metastasis.
  • Echocardiogram monitoring of sarcoma patients remains important, and should include screening for possible cardiac metastasis.

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  • (PMID = 27962495.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Moreno Antón F, Casado Herraez A, Puente Vázquez J, Gómez Díaz R, Aragoncillo P, Díaz-Rubio García E: Cardiac metastasis from uterine leiomyosarcoma. Clin Transl Oncol; 2006 May;8(5):375-8
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  • [Title] Cardiac metastasis from uterine leiomyosarcoma.
  • Cardiac metastases are more frequent than primary heart neoplasias.
  • Nearly any malignant tumour may metastasize to the heart, but the most common are carcinomas rather than sarcomas.
  • We report the case of a patient who presented with heart metastasis 6 years after resection of an uterine leiomyosarcoma.
  • The patient died thirty months after surgical resection without evidence of cardiac recurrence.
  • Although cardiac metastases from uterine leiomyosarcoma are exceptional, they should be suspected in the presence of suggestive symptoms, since they can be associated with long survival after surgical treatment.
  • [MeSH-major] Heart Neoplasms / secondary. Leiomyosarcoma / secondary. Uterine Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Dacarbazine / administration & dosage. Dacarbazine / analogs & derivatives. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Diagnostic Errors. Doxorubicin / administration & dosage. Fatal Outcome. Female. Humans. Hysterectomy. Ifosfamide / administration & dosage. Kidney Neoplasms / drug therapy. Kidney Neoplasms / secondary. Kidney Neoplasms / surgery. Leiomyoma / diagnosis. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Middle Aged. Ovariectomy. Taxoids / administration & dosage. Thoracic Surgery, Video-Assisted

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  • [Cites] Can J Surg. 1988 Nov;31(6):418-20 [3179851.001]
  • [Cites] Gynecol Oncol. 2003 Jun;89(3):460-9 [12798712.001]
  • [Cites] Cancer. 1989 Mar 1;63(5):935-8 [2914299.001]
  • [Cites] Int J Gynecol Pathol. 1990;9(1):1-19 [2152890.001]
  • [Cites] J Thorac Cardiovasc Surg. 1987 Sep;94(3):447-9 [3626608.001]
  • [Cites] Cancer. 1971 Jan;27(1):238-41 [5539626.001]
  • [Cites] Curr Opin Oncol. 2004 Jul;16(4):324-7 [15187886.001]
  • [Cites] J Thorac Cardiovasc Surg. 1989 Dec;98(6):1147-8 [2586137.001]
  • [Cites] Am J Cardiol. 1960 Sep;6:672-5 [14438967.001]
  • [Cites] Gynecol Oncol. 2004 Mar;92(3):999-1001 [14984976.001]
  • [Cites] J Am Coll Cardiol. 1983 Aug;2(2):383-6 [6863772.001]
  • [Cites] Cardiologia. 1999 Nov;44(11):1001-3 [10686777.001]
  • (PMID = 16760015.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Taxoids; 0W860991D6 / Deoxycytidine; 15H5577CQD / docetaxel; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; B76N6SBZ8R / gemcitabine; UM20QQM95Y / Ifosfamide; YF1K15M17Y / temozolomide
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16. Durrleman N, El Hamamsy I, Demaria R, Carrier M, Perrault LP, Albat B: [Is Dacron carcinogenic? Apropos of a case and review of the literature]. Arch Mal Coeur Vaiss; 2004 Mar;97(3):267-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary malignant cardiac tumours are extremely rare.
  • The authors report a case of primary cardiac lymphoma nine years after implantation of a double leaflet mitral valve prosthesis.
  • Malignant lymphoma is a haematological form of sarcoma.
  • Exceptionally rare, it is a tumour of the immune system occurring principally in immuno-depressed patients.
  • It typically presents as a nodular or diffuse myocardial infiltrate explaining its clinical expression as cardiac failure and atrioventricular block.
  • Survival after "pure" medical therapy (chemotherapy alone or associated with radiotherapy) is 6 to 8 months after diagnosis.
  • Dacron has been implicated in the pathogenesis of primary cardiac sarcoma.
  • In conclusion, although primary cardiac lymphoma is a rare condition, it should be considered, as with thrombosis, a possible differential diagnosis of acute dysfunction of cardiac valvular prostheses.
  • [MeSH-major] Heart Neoplasms / etiology. Heart Valve Prosthesis / adverse effects. Lymphoma, Large-Cell, Immunoblastic / etiology. Polyethylene Terephthalates / adverse effects
  • [MeSH-minor] Abdominal Neoplasms / drug therapy. Abdominal Neoplasms / secondary. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Asthenia / etiology. Diagnostic Errors. Fatal Outcome. Female. Humans. Mitral Valve / surgery. Multiple Organ Failure / etiology. Myxoma / diagnosis. Sarcoma / chemically induced. Thrombosis / diagnosis

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  • (PMID = 15106752.001).
  • [ISSN] 0003-9683
  • [Journal-full-title] Archives des maladies du coeur et des vaisseaux
  • [ISO-abbreviation] Arch Mal Coeur Vaiss
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Polyethylene Terephthalates
  • [Number-of-references] 10
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17. Mioulet D, Braem L, Heno P, Paule P, Peloni JM, Bonnet D, Fourcade L: [Cardiac extension of a non-Hodgkin lymphoma revealed by an atrial flutter]. Ann Cardiol Angeiol (Paris); 2009 Apr;58(2):117-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cardiac extension of a non-Hodgkin lymphoma revealed by an atrial flutter].
  • Primary or secondary cardiac lymphomas are not frequent.
  • Their clinical expression is unusual and the diagnosis is rarely made during the patient's life.
  • Our case report, which is a slow atrial flutter with a pericardial effusion, is an uncommon discovery mode for a malignant lymphoma.
  • Their diagnosis and the mechanism of the arythmia were allowed by non-invasive cardiac imagery (transesophageal echography and magnetic resonance imaging), which showed a tumour-like infiltration of the right atrium, of the right ventricle posterior wall, and of the atrioventricular junction.
  • The diagnosis of a high grade B cell malignant non-hodgkin lymphoma, involving the bone marrow, the liver and the kidneys was made by biopsies of lymph nodes, histological analysis of the bone marrow, and a body CT scan.
  • Throughout the first chemotherapy sequence, we observed a spontaneous return to a sinusal rhythm, and the cardiac MRI showed a regression of the myocardial infiltration and of the pericardial effusion; moreover, the patient's state improved and the peripheral lymph nodes shrank back to a normal size.
  • However, the patient passed away, due to neurological complications 13 months after the diagnosis of lymphoma, without recurrence of cardiac involvement.
  • [MeSH-major] Atrial Flutter / etiology. Heart Neoplasms / complications. Lymphoma, B-Cell / complications

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  • (PMID = 18657797.001).
  • [ISSN] 1768-3181
  • [Journal-full-title] Annales de cardiologie et d'angéiologie
  • [ISO-abbreviation] Ann Cardiol Angeiol (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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18. Butany J, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T: Cardiac tumours: diagnosis and management. Lancet Oncol; 2005 Apr;6(4):219-28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac tumours: diagnosis and management.
  • Primary cardiac tumours are rare, with an autopsy incidence ranging from 0.001% to 0.030%.
  • Metastases to the heart are far more common than primary cardiac tumours.
  • Primary cardiac tumours present with one or more of the symptoms of the classic triad of: cardiac symptoms and signs resulting from intracardiac obstruction; signs of systemic embolisation; and systemic or constitutional symptoms.
  • Whereas surgery is indicated in patients with benign tumours, systemic chemotherapy is indicated in those who have widespread or unresectable malignant disease, and chemotherapy and radiotherapy are usually combined in treatment of patients with primary cardiac lymphomas.
  • The prognosis after surgery is usually excellent in the case of benign tumours but is unfortunately still limited in localised malignant diseases.
  • [MeSH-major] Heart Neoplasms
  • [MeSH-minor] Echocardiography. Humans. Magnetic Resonance Imaging. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 15811617.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 57
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19. Moreno-Vega AL, Fuentes-Pradera J, Gordón-Santiago Mdel M, Vargas-Machuca JC: Intraventricular metastases from rectal-sigmoid adenocarcinoma. Clin Transl Oncol; 2006 Apr;8(4):296-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraventricular metastases from rectal-sigmoid adenocarcinoma.
  • Secondary cardiac tumours are rare.
  • The new diagnostic technology and more effective chemotherapy schedules for primary tumours, leading to a longer survival, have increased the frequency of such tumors.
  • Adenocarcinoma accounted for around 40% of all metastases to the heart; the most frequently involved sites are pericardium and epicardium.
  • We present a patient with an unusual intraventricular metastases from adenocarcinoma of rectal-sigmoid origin.
  • [MeSH-major] Adenocarcinoma / secondary. Heart Neoplasms / secondary. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Capecitabine. Cardiac Tamponade / etiology. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Dyspnea / etiology. Fatal Outcome. Female. Fluorouracil / analogs & derivatives. Heart Ventricles / diagnostic imaging. Humans. Liver Neoplasms / secondary. Organoplatinum Compounds / administration & dosage. Palliative Care. Radiography. Ultrasonography

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  • [Cites] Int J Cardiovasc Imaging. 2005 Feb;21(1):115-31 [15915945.001]
  • [Cites] Cancer. 1990 Mar 15;65(6):1456-9 [2306690.001]
  • [Cites] Heart. 2002 Apr;87(4):328 [11907002.001]
  • [Cites] Acta Cardiol. 1994;49(2):191-6 [8053287.001]
  • [Cites] Clin Cardiol. 1999 Nov;22(11):749 [10554692.001]
  • [Cites] Jpn J Clin Oncol. 1988 Sep;18(3):195-201 [3411785.001]
  • [Cites] Int Surg. 2001 Jul-Sep;86(3):198-200 [11996080.001]
  • [Cites] Tex Heart Inst J. 1993;20(4):296-8 [8298329.001]
  • (PMID = 16648108.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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20. Rafajlovski S, Tatić V, Ilić S, Kanjuh V: [Frequency of metastatic tumors in the heart]. Vojnosanit Pregl; 2005 Dec;62(12):915-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Frequency of metastatic tumors in the heart].
  • INTRODUCTION: Secondary or metastatic tumors in the heart occur more frequently than primary ones, and, according to the published series, their frequency found in autopsic material ranges from 1.6% to 20.6%.
  • Metastatic tumors in the heart are rarely clinically symptomatic, and, therefore, they are rarely diagnosed within the lifetime.
  • The aim of this study was to analyze the frequency of metastatic tumors of the heart, their primary localization, as well as the localization of the metastases found in the autopsic material within the period 1972-2004.
  • METHODS: During the autopsy of the patients died of metastatic tumors, we microscopically and macroscopically analyzed all the organs and tissues to determine the metastases of primary tumors in other organs, especially in the heart and pericardium.
  • In 2 928 (25.6%) out of 11 403 autopsies, the presence of malignant tumor was diagnosed, and in 79 (2.7%) of these cases, metastasis of the heart was found out.
  • Only in 5 of the cases, the presence of metastasis in the heart was diagnosed during the lifetime.
  • The most frequent metastases in the heart were caused by pulmonary carcinoma (18 cases), leukemia and malignant lymphoma (8 cases, each), then pancreatic and breast carcinoma, while the metastases of other carcinomas were rather rare.
  • In 40 (60.76%) cases, the metastasis was localized in the myocardium, but more often in the left ventricle, in 24 (30.38%) cases in the pericardium, in 4 cases in the epicardium and in the 3 of them in the mitral and tricuspid valve.
  • Only in one case of renal carcionoma, metastasis was found in the right atrium and it occurred by spreading (dissemination) through the lumen of the inferior vena cava.
  • CONCLUSION: Metastatic tumors of the heart are rather rare, and rarely clinically symptomatic, and, thus, rarely diagnosed during life.
  • The methods of choice for the diagnosis of the metastasis in the heart are echocardiography, computerized tomography, magnetic resonance imaging, cytological analysis of the pericardial effusion and biopsy.
  • The treatment includes surgery, chemotherapy and radiotherapy.
  • [MeSH-major] Heart Neoplasms / secondary

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  • (PMID = 16375220.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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21. Savoia P, Fierro MT, Zaccagna A, Bernengo MG: Metastatic melanoma of the heart. J Surg Oncol; 2000 Nov;75(3):203-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic melanoma of the heart.
  • BACKGROUND: Malignant melanoma has an unpredictable biologic behavior and is the neoplasm with the greatest propensity for cardiac involvement.
  • Although relatively frequent at autopsy, cardiac metastases are rarely identified antemortem.
  • METHODS: We reviewed 2,810 patients with histologically confirmed malignant melanoma, who were diagnosed and followed up by our clinic.
  • RESULTS: Five cases of metastatic melanoma of the heart were identified out of 314 melanoma patients with visceral involvement.
  • One case of a 53-year-old woman, who died unexpectedly during her first chemotherapy course, is described in detail.
  • Postmortem examination determined the cause of death to be the presence of multiple melanoma metastases in the heart, even though the patient had shown no signs of cardiac involvement.
  • CONCLUSIONS: The unpredictable biologic behavior of melanoma may lead to unusual metastatic sites, and, therefore, the heart also should be included in routine examinations.
  • [MeSH-major] Heart Neoplasms / pathology. Heart Neoplasms / secondary. Melanoma / pathology. Melanoma / secondary

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  • [Copyright] Copyright 2000 Wiley-Liss, Inc.
  • (PMID = 11088053.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
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22. Lim ZY, Grace R, Salisbury JR, Creamer D, Jayaprakasam A, Ho AY, Devereux S, Mufti GJ, Pagliuca A: Cardiac presentation of ALK positive anaplastic large cell lymphoma. Eur J Haematol; 2005 Dec;75(6):511-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac presentation of ALK positive anaplastic large cell lymphoma.
  • Cardiac involvement as an initial presentation of malignant lymphoma is a rare occurrence.
  • We report the case of an immunocompetent 29-year-old male who presented with syncope and arrythmias secondary to a ventricular cardiac mass.
  • Transcutaneous cardiac biopsy was non-diagnostic, therefore an open cardiac biopsy was performed from which a provisional diagnosis of a cardiac inflammatory pseudotumour was made.
  • Six months after presentation, he developed several subcutaneous lesions with systemic symptoms.
  • Histological and immunophenotypic review of the initial cardiac biopsy revealed features consistent with a diagnosis of CD30, ALK1 positive anaplastic large cell lymphoma (ALCL).
  • Despite intensive treatment with combination chemotherapy, there was significant progression of disease, and he died 11 months after diagnosis.
  • The overall prognosis of cardiac lymphoma remains poor, which may be due to the often late presentation of the tumour.
  • To our knowledge, this is the first reported case of a cardiac ALK positive ALCL.
  • Although rare, cardiac presentation of ALCL should be added to the list of differential diagnoses of cardiac lymphomas.
  • [MeSH-major] Activin Receptors, Type I. Heart Neoplasms / pathology. Lymphoma, Large-Cell, Anaplastic / pathology
  • [MeSH-minor] Activin Receptors, Type II. Adult. Biopsy / methods. Humans. Immunohistochemistry / methods. Male

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  • (PMID = 16313264.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.11.30 / ACVRL1 protein, human; EC 2.7.11.30 / Activin Receptors, Type I; EC 2.7.11.30 / Activin Receptors, Type II
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23. Mazzoccoli G, Carughi S, La Viola M, De Cata A, Puzzolante F, Camagna A, Russo A, Caparrotti S: [Cardiac metastasis of poorly differentiated adenocarcinoma of unknown primary site]. Ital Heart J Suppl; 2002 Nov;3(11):1112-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cardiac metastasis of poorly differentiated adenocarcinoma of unknown primary site].
  • [Transliterated title] Metastasi cardiache di adenocarcinoma poco differenziato a sede primitiva occulta.
  • Brain magnetic resonance imaging showed multiple metastatic lesions, computed tomography of the chest, abdomen and pelvis showed intraatrial masses and whole body nuclear scanning evidenced bone lesion.
  • It was not possible to find the primary tumor by other instrumental or laboratory exams.
  • The patient was transferred to the operating room for cardiac surgery, the mass at risk for embolization was resected and the specimen consisted of fibrous and fibrino-necrotic tissue infiltrated by poorly differentiated adenocarcinoma.
  • The patient received brain and bone radiotherapy and chemotherapy with cisplatin and vinorelbin.
  • [MeSH-major] Adenocarcinoma / secondary. Heart Neoplasms / secondary. Neoplasms, Unknown Primary / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Echocardiography. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 12506513.001).
  • [ISSN] 1129-4728
  • [Journal-full-title] Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology
  • [ISO-abbreviation] Ital Heart J Suppl
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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24. Díaz Beveridge R, Richart Aznar P, Núñez Lozano C, Chirivella Casanova M, Corbellas Aparicio M, Montalar Salcedo J: Orbital and myocardial metastases of a primary pulmonary melanotic schwannoma. Clin Transl Oncol; 2010 Jul;12(7):509-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital and myocardial metastases of a primary pulmonary melanotic schwannoma.
  • We present the case of a 60-year-old man with a primary pulmonary melanotic schwannoma treated with surgery and who developed an orbital and myocardial relapse 2 years after the initial diagnosis.
  • In more than half of cases, the Carney triad of myxomas of the heart, skin and breast, spotty pigmentation and endocrine hyperactivity is present.
  • A thorough pathological study is pivotal for a correct diagnosis.
  • The main differential diagnosis is with metastases of malignant melanoma.
  • Treatment should include radical surgery if possible; the role of chemotherapy and radiotherapy is uncertain due to the rarity of the tumour.
  • [MeSH-major] Heart Neoplasms / secondary. Lung Neoplasms / pathology. Myocardium / pathology. Neurilemmoma / secondary. Orbital Neoplasms / secondary

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  • [Cites] Am J Surg Pathol. 1996 Mar;20(3):259-72 [8772778.001]
  • [Cites] J Clin Pathol. 2002 Apr;55(4):318-20 [11919222.001]
  • [Cites] Am J Surg Pathol. 1979 Feb;3(1):3-10 [534381.001]
  • [Cites] Histopathology. 1984 Sep;8(5):881-94 [6519652.001]
  • [Cites] Histopathology. 1999 Dec;35(6):558-66 [10583580.001]
  • [Cites] Am J Surg Pathol. 1984 Feb;8(2):129-38 [6703189.001]
  • [Cites] Cancer. 1988 Jul 1;62(1):174-83 [3289725.001]
  • [Cites] Am J Surg Pathol. 1990 Mar;14(3):206-22 [2305928.001]
  • [Cites] Int J Oral Maxillofac Surg. 2006 Aug;35(8):767-71 [16580816.001]
  • [Cites] Pathol Res Pract. 1996 Nov;192(11):1142-6; discussion 1147 [9122034.001]
  • [Cites] Cancer. 1975 Dec;36(6):2029-41 [1203861.001]
  • [Cites] Cancer. 1986 May 15;57(10):2006-21 [3082508.001]
  • (PMID = 20615829.001).
  • [ISSN] 1699-3055
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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25. Rubiales AS, Reyes A, Renedo AF, Torrego JC, Puertas J, Marcos G: Heart metastases and superior vena cava syndrome. Clin Transl Oncol; 2007 Aug;9(8):540-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Heart metastases and superior vena cava syndrome.
  • Superior vena cava syndrome (SVCS) may be due to a tumour infiltrating the right atrium.
  • The first one was secondary to solitary atrial metastases of rectal adenocarcinoma and benefited from palliative chemotherapy.
  • [MeSH-major] Heart Atria. Heart Neoplasms / secondary. Superior Vena Cava Syndrome / etiology
  • [MeSH-minor] Adenocarcinoma / secondary. Adult. Aged. Female. Humans. Lymphoma, B-Cell / pathology. Radiography

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  • [Cites] Int J Hematol. 1999 Oct;70(3):174-7 [10561910.001]
  • [Cites] Clin Nucl Med. 1989 Sep;14 (9):698-9 [2791428.001]
  • [Cites] Jpn J Thorac Cardiovasc Surg. 2003 Jul;51(7):330-2 [12892468.001]
  • [Cites] Am Heart J. 1994 Feb;127(2):465-8 [8296725.001]
  • [Cites] Orv Hetil. 1991 Mar 24;132(12):639-41 [2011388.001]
  • [Cites] Echocardiography. 2002 Jan;19(1):61-2 [11884256.001]
  • [Cites] Ann Med Interne (Paris). 1987;138(8):672-4 [3450219.001]
  • [Cites] Intern Med. 2000 Feb;39(2):139-42 [10732831.001]
  • [Cites] J Am Soc Echocardiogr. 1990 Mar-Apr;3(2):149-53 [2185795.001]
  • [Cites] Magn Reson Imaging. 1998;16(1):91-5 [9436953.001]
  • (PMID = 17720658.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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26. Díaz ML, Villanueva A, Bastarrika G, Zudaire B, del Barrio LG, Noguera JJ: Non-electrocardiogram-gated multidetector-row computed tomography findings of cardiac pathology in oncologic patients. Curr Probl Diagn Radiol; 2009 Sep-Oct;38(5):206-17
MedlinePlus Health Information. consumer health - Heart Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-electrocardiogram-gated multidetector-row computed tomography findings of cardiac pathology in oncologic patients.
  • Multidetector-row computed tomography (MDCT) plays an essential role in oncologic imaging as the modality of mapping out the treatment strategy at staging, assessing response to the treatment, and following up patient outcome after the treatment.
  • Even without electrocardiogram gating, MDCT provides accurate information about the heart.
  • In the group of oncologic patients, different tumoral and non-tumoral-related heart disorders can be found, for example, metastatic cardiac involvement (approximately 10% of patients with lung or breast cancer will develop metastases to the heart), paraneoplastic cardiac disorders, non-tumor-related heart disorders, and chemotherapy- and radiotherapy-related cardiac side effects.
  • MDCT plays a role in the detection of these entities.
  • We show the non-electrocardiogram-gated MDCT findings of oncology-related cardiac disorders to encourage radiologists to recognize and report cardiac findings in oncologic patients.
  • Appropriate knowledge of tumoral and non-tumoral-related MDCT features allows a complete evaluation of oncologic patients with ancillary cardiac findings.
  • An adequate knowledge of the patient's medical history, previous treatments, and concomitant illnesses is essential to interpret heart findings in oncologic patients who undergo MDCT.
  • [MeSH-major] Heart Diseases / complications. Heart Diseases / radiography. Heart Neoplasms / radiography. Heart Neoplasms / secondary. Neoplasms / pathology. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Carcinoid Heart Disease / radiography. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Male. Melanoma / radiography. Neoplasm Invasiveness. Neoplasm Staging. Pericardial Effusion / etiology. Pericardial Effusion / radiography. Pericardium. Prostatic Neoplasms / complications. Retrospective Studies

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  • (PMID = 19632498.001).
  • [ISSN] 1535-6302
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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27. Helige C, Hofmann-Wellenhof R, Fink-Puches R, Smolle J: Mofarotene-induced inhibition of melanoma cell motility by increasing vinculin-containing focal contacts. Melanoma Res; 2004 Dec;14(6):547-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumour cell motility, which is dependent on the organization of the cytoskeleton, is considered to play an important role in the spread of malignant melanoma.
  • In this study, the effects of the arotinoid mofarotene on single cell motility and vinculin organization of the highly metastatic melanoma cell line K-1735-M2 were determined.
  • Cell movements were evaluated quantitatively from time-lapse video recordings using an IBAS image analysis system.
  • Vinculin distribution was evaluated using confocal laser scanning microscopy and a specially developed computerized image analysing program.
  • In addition, melanoma cell invasion was tested on the embryonic chick heart model.
  • Furthermore, the compound reduced the invasiveness of melanoma cells in a three-dimensional tissue culture model.
  • In conclusion, our data demonstrate that mofarotene, an already almost forgotten synthetic retinoid, shows interesting effects on melanoma cells, which may be relevant for a slowdown of tumour spread.
  • [MeSH-major] Cell Movement / drug effects. Focal Adhesions / drug effects. Melanoma, Experimental / drug therapy. Morpholines / pharmacology. Retinoids / pharmacology. Vinculin / metabolism
  • [MeSH-minor] Actins / metabolism. Animals. Cell Adhesion / drug effects. Chick Embryo. Chickens. Collagen / metabolism. Drug Combinations. Heart / drug effects. Laminin / metabolism. Lung Neoplasms / drug therapy. Lung Neoplasms / metabolism. Lung Neoplasms / secondary. Mice. Neoplasm Invasiveness / pathology. Proteoglycans / metabolism. Skin Neoplasms. Spheroids, Cellular / drug effects. Tumor Cells, Cultured

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  • (PMID = 15577329.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Drug Combinations; 0 / Laminin; 0 / Morpholines; 0 / Proteoglycans; 0 / Retinoids; 119978-18-6 / matrigel; 125361-02-6 / Vinculin; 8K3CVY8F8V / mofarotene; 9007-34-5 / Collagen
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