[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 20 of about 20
1. Bakshi A, Biswas G, Deshmukh C, Prasad N, Nair R, Parikh PM: Successful complete regression of isolated intramedullary spinal cord metastases from epithelial ovarian carcinoma with chemotherapy and radiotherapy. Indian J Cancer; 2006 Jul-Sep;43(3):136-8
Hazardous Substances Data Bank. ETOPOSIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful complete regression of isolated intramedullary spinal cord metastases from epithelial ovarian carcinoma with chemotherapy and radiotherapy.
  • Advances in the management of ovarian cancer by use of aggressive surgery and effective platinum-based chemotherapy have prolonged survival; this may have resulted in an alteration of the metastatic pattern of the disease and spread to unusual sites (e.g, CNS) has become more common.
  • Intramedullary spinal cord metastasis is rare.
  • We report one such case treated successfully with chemotherapy and radiotherapy with long-term survival.
  • [MeSH-major] Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / radiotherapy. Spinal Cord Neoplasms / drug therapy. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Administration, Oral. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. CA-125 Antigen / cerebrospinal fluid. Combined Modality Therapy. Cystadenocarcinoma, Serous / drug therapy. Cystadenocarcinoma, Serous / radiotherapy. Drug Administration Schedule. Etoposide / administration & dosage. Etoposide / therapeutic use. Female. Humans. Lumbar Vertebrae / radiography. Remission Induction / methods

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17065773.001).
  • [ISSN] 0019-509X
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / CA-125 Antigen; 6PLQ3CP4P3 / Etoposide
  •  go-up   go-down


2. Ngan RK, Yiu HH, Cheng HK, Chan JK, Sin VC, Lau WH: Central nervous system metastasis from nasopharyngeal carcinoma: a report of two patients and a review of the literature. Cancer; 2002 Jan 15;94(2):398-405
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Central nervous system metastasis from nasopharyngeal carcinoma: a report of two patients and a review of the literature.
  • BACKGROUND: Central nervous system (CNS) metastasis from nasopharyngeal carcinoma (NPC) is an extremely rare occurrence, although direct intracranial invasion is not infrequent in patients with NPC at a locally advanced stage.
  • METHODS: The clinical records of two such patients with NPC who were diagnosed with metastasis to the spinal cord (intradural) and to the occipital lobe, respectively, were reviewed.
  • RESULTS: Both patients had locally advanced disease at the time of presentation and were treated with neoadjuvant chemotherapy and radical radiotherapy.
  • Spread through cerebral spinal fluid was postulated for the patient with spinal cord metastasis, and hematogenous spread was postulated for the patient with brain metastasis.
  • The patient with brain metastasis died 6 months later of lung metastasis, whereas the other patient is still alive 40 months from the diagnosis of spinal metastasis.
  • CONCLUSIONS: Good symptom control and disease control can be achieved for patients with CNS metastasis after surgery with or without radiotherapy.
  • After aggressive therapy, the ultimate survival depends on control of extracranial disease.
  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma, Squamous Cell / secondary. Nasopharyngeal Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Fatal Outcome. Herpesvirus 4, Human / genetics. Herpesvirus 4, Human / metabolism. Humans. In Situ Hybridization. Male. Middle Aged. Prognosis. Radiotherapy, Adjuvant. Survival

  • Genetic Alliance. consumer health - Nasopharyngeal carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11905411.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
  •  go-up   go-down


3. Engebraaten O, Sivam G, Juell S, Fodstad O: Systemic immunotoxin treatment inhibits formation of human breast cancer metastasis and tumor growth in nude rats. Int J Cancer; 2000 Dec 15;88(6):970-6
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Systemic immunotoxin treatment inhibits formation of human breast cancer metastasis and tumor growth in nude rats.
  • Adjuvant chemotherapy in breast cancer patients has had limited success, which is possibly because of lack of effect on non-proliferating cells accompanied by the emergence of drug-resistant cell clones.
  • In the MA-11 model in nude rats, a single i. v. dose of 20 microg MOC31-PE prevented development of metastasis in the spinal cord in 11/19 (58%) of the animals.
  • Similarly, 425.3-PE treatment gave 6/9 (66%) long-term survivors.
  • In rats injected intracardially or intratibially with MT-1 cells, treatment with 425.
  • 3-PE prevented metastasis in 4/10 (40%) and intratibial tumor growth in 17/18 (94%) of the rats.
  • The results demonstrate that systemic short-term treatment with non-toxic doses of the 3 ITs tested can effectively inhibit the development of experimental breast cancer metastasis and/or local tumor growth in bone.
  • The results support the development of the ITs towards clinical evaluation for possible use as short-term adjuvant therapy in patients at high risk of early relapse.
  • [MeSH-major] ADP Ribose Transferases. Antibodies, Monoclonal / therapeutic use. Bacterial Toxins. Breast Neoplasms / therapy. Exotoxins / therapeutic use. Immunotoxins / therapeutic use. Receptor, Epidermal Growth Factor / immunology. Virulence Factors
  • [MeSH-minor] Animals. Antineoplastic Agents / therapeutic use. Bone Neoplasms / prevention & control. Bone Neoplasms / secondary. Cisplatin / therapeutic use. Doxorubicin / therapeutic use. Female. Injections, Intravenous. Male. Rats. Rats, Nude. Specific Pathogen-Free Organisms. Spinal Neoplasms / prevention & control. Spinal Neoplasms / secondary. Tibia. Tumor Cells, Cultured

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2000 Wiley-Liss, Inc.
  • (PMID = 11093823.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / Bacterial Toxins; 0 / Exotoxins; 0 / Immunotoxins; 0 / Virulence Factors; 80168379AG / Doxorubicin; EC 2.4.2.- / ADP Ribose Transferases; EC 2.4.2.31 / toxA protein, Pseudomonas aeruginosa; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; Q20Q21Q62J / Cisplatin
  •  go-up   go-down


Advertisement
4. Fujimoto N, Hiraki A, Ueoka H, Kiura K, Bessho A, Takata I, Hiramatsu Y, Ikeda K, Harada M: Intramedullary spinal cord recurrence after high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation for limited-disease small cell lung cancer. Lung Cancer; 2000 Nov;30(2):145-8
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord recurrence after high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation for limited-disease small cell lung cancer.
  • Intramedullary spinal cord metastasis is very rare in small-cell lung cancer (SCLC), and develops in only 2% of neurological disorders associated with SCLC according to previous reports.
  • We describe here a patient with SCLC who developed intramedullary spinal cord recurrence after high-dose chemotherapy (HDCT) followed by autologous blood progenitor cell transplantation (ABPCT).
  • A 59-year-old Japanese male was referred to us for diagnosis and treatment of an abnormal shadow on a chest radiograph.
  • Magnetic resonance imaging (MRI) of the spinal cord disclosed an intramedullary tumor exhibiting an enhancement effect with Gd-DTPA at the 11-12th level of the thoracic vertebra.
  • Immediately, radiotherapy to the spinal cord metastasis was given at a dose of 30 Gy, and his neurological disorders were completely resolved.
  • At this time of reporting, he is doing well without recurrence.
  • This case indicates that intramedullary spinal cord is one of the recurrence sites implicated after HDCT and PCI in LD-SCLC.
  • [MeSH-major] Carcinoma, Small Cell / secondary. Lung Neoplasms / pathology. Neoplasms, Second Primary. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Combined Modality Therapy. Drug Therapy. Hematopoietic Stem Cell Transplantation. Humans. Male. Medulla Oblongata. Middle Aged. Transplantation, Autologous

  • Genetic Alliance. consumer health - Lung Cancer.
  • Genetic Alliance. consumer health - Transplantation.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11086208.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] IRELAND
  •  go-up   go-down


5. Nakadate M, Harad M, Isobe H: [Clinical features of intradural spinal cord metastases in primary lung cancer]. Nihon Kokyuki Gakkai Zasshi; 2005 Sep;43(9):541-6
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical features of intradural spinal cord metastases in primary lung cancer].
  • We retrospectively investigated the clinical features of 9 consecutive cases of intradural spinal cord metastasis from primary lung cancer treated at our hospital between April 1999 and March 2002.
  • During those three years, spinal cord metastasis was diagnosed in seven of 49 (14.3%) cases with small cell carcinoma and only two of 284 (0.7%) cases with non-small cell carcinoma.
  • Eight of the 9 cases had concomitant brain metastasis that preceded spinal cord metastasis and had received brain irradiation.
  • The other patient without brain metastasis had also received prophylactic cranial irradiation.
  • The interval from brain irradiation to the diagnosis of spinal cord metastasis ranged from 116 to 708 days (median 183 days).
  • Seven of the patients rapidly developed transverse myelopathy within two weeks.
  • Spinal cord metastasis was often multifocal, and in each case lumbar enlargement was commonly involved.
  • Radiation therapy with or without concurrent chemotherapy produced both neurologic improvement and a tumor response shown on MRI in 4 patients.
  • Heightened awareness of the increasing incidence and background risk factors of this unusual complication could lead to earlier diagnosis and more effective treatment for neurologic palliation.
  • [MeSH-major] Lung Neoplasms / pathology. Spinal Cord / pathology. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adenocarcinoma / secondary. Carcinoma, Small Cell / radiotherapy. Carcinoma, Small Cell / secondary. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / secondary. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiotherapy Dosage

  • Genetic Alliance. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16218424.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


6. Tashima M, Ono N, Noguchi T, Ishikawa H, Kamakari K, Terada Y: [Two cases of intramedullary spinal cord metastasis of lung cancer detected with MRI]. Nihon Kokyuki Gakkai Zasshi; 2003 Apr;41(4):320-3
Hazardous Substances Data Bank. GADOPENTETATE DIMEGLUMINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Two cases of intramedullary spinal cord metastasis of lung cancer detected with MRI].
  • We report two cases of intramedullary spinal cord metastasis of lung cancer detected by MRI.
  • Case 1: A 77-year-old man underwent chemotherapy and left lower lung lobectomy for squamous cell carcinoma of the lung (T2N0M0).
  • The pathological diagnosis was squamous cell carcinoma.
  • Case 2: A small cell carcinoma of lung with metastasis to bone, kidney and cerebellum (T4 N3 M1) in a 73-year-old man was diagnosed.
  • He showed a partial response to chemotherapies and to whole brain radiation (45 Gy).
  • [MeSH-major] Carcinoma, Small Cell / secondary. Carcinoma, Squamous Cell / secondary. Lung Neoplasms / pathology. Magnetic Resonance Imaging. Spinal Cord Neoplasms / secondary

  • Genetic Alliance. consumer health - Lung Cancer.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • MedlinePlus Health Information. consumer health - MRI Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12795190.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] K2I13DR72L / Gadolinium DTPA
  •  go-up   go-down


7. Cormio G, Di Vagno G, Di Fazio F, Loverro G, Selvaggi L: Intramedullary spinal cord metastasis from ovarian carcinoma. Gynecol Oncol; 2001 Jun;81(3):506-8
Hazardous Substances Data Bank. CARBOPLATIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord metastasis from ovarian carcinoma.
  • BACKGROUND: Intramedullary spinal cord involvement by ovarian carcinoma is extremely rare.
  • CASE: A patient with stage IV serous cystadenocarcinoma of the ovary presented with neurologic complaints 16 months after primary treatment.
  • Magnetic resonance imaging demonstrated a metastatic lesion in the intramedullary area of the spinal cord.
  • No other site of metastatic disease was observed.
  • Following chemotherapy she was given radiotherapy on the spinal cord, but died 10 months later for disseminated abdominal disease, without neurologic symptoms.
  • CONCLUSION: Spinal cord involvement is unusual in ovarian carcinoma; multidisciplinary treatment, including chemotherapy and radiotherapy, may offer good palliation of the symptomatology.
  • [MeSH-major] Cystadenocarcinoma, Serous / secondary. Ovarian Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Carboplatin / therapeutic use. Female. Humans. Middle Aged

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2001 Academic Press.
  • (PMID = 11371147.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; BG3F62OND5 / Carboplatin
  •  go-up   go-down


8. Aryan HE, Farin A, Nakaji P, Imbesi SG, Abshire BB: Intramedullary spinal cord metastasis of lung adenocarcinoma presenting as Brown-Sequard syndrome. Surg Neurol; 2004 Jan;61(1):72-6
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord metastasis of lung adenocarcinoma presenting as Brown-Sequard syndrome.
  • BACKGROUND: It is extremely rare for cancer to present first as an intramedullary spinal cord metastasis.
  • Furthermore, because it is unlikely for spinal cord neoplasm to present acutely, an acute presentation may signify metastatic disease and should be considered in the initial differential diagnosis.
  • METHODS: The authors present a case of a 59-year-old man presenting with Brown-Sequard syndrome and in whom metastatic lung adenocarcinoma to the spinal cord was subsequently discovered.
  • Review of the literature reveals this case to be one of only a very few where intramedullary tumor was the first manifestation of metastatic disease.
  • RESULTS: The mainstay of treatment for intramedullary spinal metastases remains steroids, radiation, and chemotherapy, though no well-designed study compares these modalities by long-term survival and functional results.
  • This patient underwent local radiation and systemic chemotherapy following surgical resection.
  • CONCLUSIONS: This patient had no preoperative signs suggesting disease in other organs, making the diagnosis of lung adenocarcinoma metastatic to the intramedullary cord surprising, especially given the extremely rare incidence of spinal intramedullary metastatic disease.
  • However, the patient had an acute presentation, uncommon for primary neoplasm, which may be an indication of metastatic disease.
  • [MeSH-major] Adenocarcinoma / secondary. Brown-Sequard Syndrome / diagnosis. Lung Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures / methods. Postoperative Period

  • Genetic Alliance. consumer health - Brown Syndrome.
  • Genetic Alliance. consumer health - Brown-Sequard Syndrome.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 14706385.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
  •  go-up   go-down


9. Kodama M, Kawaguchi H, Komoto Y, Takemura M: Coexistent intramedullary spinal cord and choroidal metastases in ovarian cancer. J Obstet Gynaecol Res; 2010 Feb;36(1):199-203
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistent intramedullary spinal cord and choroidal metastases in ovarian cancer.
  • Involvement of intramedullary spinal cord and the choroid by ovarian cancer is rare, and coexistence of metastases at these sites is extremely rare and has never been reported.
  • This condition rapidly progresses to a neurological emergency; however, an efficient standard treatment method is not available for this rare condition.
  • She presented with blindness and other neurologic complaints during the course of treatment for a recurrence at 50 months after the primary surgical treatment for the tumor.
  • Magnetic resonance imaging (MRI) revealed intramedullary spinal cord metastasis and choroidal metastasis, coexisting with multiple brain metastases and intra-abdominal lesions.
  • Neurological emergency was prevented by administering whole-brain irradiation therapy followed by systemic chemotherapy.
  • Early diagnosis and multidisciplinary treatment, including radiotherapy and chemotherapy, may offer good palliation for such unusual metastases of ovarian cancer.
  • [MeSH-major] Brain Neoplasms / secondary. Choroid Neoplasms / secondary. Cystadenocarcinoma, Serous / secondary. Neoplasm Recurrence, Local. Ovarian Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Abdominal Neoplasms / secondary. Abdominal Neoplasms / therapy. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Hysterectomy. Ovariectomy

  • Genetic Alliance. consumer health - Ovarian cancer.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20178552.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  •  go-up   go-down


10. Kaal EC, Vecht CJ: CNS complications of breast cancer: current and emerging treatment options. CNS Drugs; 2007;21(7):559-79
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CNS complications of breast cancer: current and emerging treatment options.
  • The choice of appropriate therapy for brain metastases also depends on prognostic factors, including the age of the patient, the Karnofsky performance score, the number of brain metastases and the presence of systemic disease.
  • Surgery followed by whole brain radiation therapy (WBRT) is generally restricted to ambulant patients with a single brain metastasis without active extracranial disease.
  • Although breast carcinoma is sensitive to chemotherapy, the role of chemotherapy in the treatment of brain metastases is still unclear.
  • Objective responses after cyclophosphamide-based therapies were reported in studies performed in the 1980s.
  • A randomised study in patients with leptomeningeal disease secondary to breast cancer has revealed that intrathecal chemotherapy is associated with substantially more adverse effects than non-intrathecal treatment, without a clear benefit in terms of response or survival.
  • Intramedullary metastasis is rare but often presents with a rapidly progressive myelopathy.
  • Epidural spinal cord metastasis occurs in approximately 4% of patients and can lead to paraplegia.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / therapy. Breast Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Clinical Trials as Topic. Female. Humans. Incidence. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / secondary. Meningeal Neoplasms / therapy. Risk Factors. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / secondary. Spinal Cord Neoplasms / therapy


11. Wada H, Ieki R, Ota T, Iguchi M, Yuasa K, Okamura T, Karasawa K, Goto H: [Intramedullary spinal cord metastasis of lung adenocarcinoma causing Brown-Séquard Syndrome]. Nihon Kokyuki Gakkai Zasshi; 2001 Aug;39(8):590-4
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intramedullary spinal cord metastasis of lung adenocarcinoma causing Brown-Séquard Syndrome].
  • A 36-year-old woman admitted to our hospital because of numbness in the left limbs and weakness in the right arm, and was subsequently given a diagnosis of intramedullary spinal cord metastases from lung cancer.
  • Occipital craniotomy, radiation therapy and chemotherapy were performed on the lesions in the year following June 1994.
  • Compatible with her neurological manifestation, MRI demonstrated tumors in the right side of the cord at the spinal level of C3-4 and C7-Th1, both of which were of high density in T2-enhanced conditions with enhancement by gadolinium-diethylenetriamine pentaacetic acid.
  • No invasion from spinal metastasis was detected by CT, scintigraphy or MRI.
  • We therefore diagnosed her manifestation as Brown-Séquard syndrome caused by intramedullary spinal cord metastatic tumors of lung adenocarcinoma.
  • In order to avoid paraplegia and dysfunction of the bladder and bowel, radiation therapy of the cord lesions with total dose of 44 Gy was performed.
  • Her neurologic manifestation was improved, restoring her quality of life, as the tumor size estimated by MRI decreased.
  • Four months later, however, she died of lung adenocarcinoma that developed accompanied with severe peritonitis carcinomatosa and multiple metastases.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Brown-Sequard Syndrome / etiology. Lung Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Fatal Outcome. Female. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging


12. Cormio G, Colamaria A, Di Vagno G, De Tommasi A, Loverro G, Selvaggi L: Surgical decompression and radiation therapy in epidural metastasis from cervical cancer. Eur J Obstet Gynecol Reprod Biol; 2000 Mar;89(1):59-61
MedlinePlus Health Information. consumer health - Cervical Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical decompression and radiation therapy in epidural metastasis from cervical cancer.
  • Spinal cord compression by epidural metastasis is considered an exceptional complication in patients with cervical carcinoma.
  • We report three patients treated for a cervical carcinoma who developed epidural metastasis with spinal cord compression at 9, 25 and 48 months after primary treatment of the uterine malignancy.
  • All patients had poorly-differentiated adenocarcinomas with lymphovascular space invasion, and two had lymph node metastasis.
  • In two patients the spinal cord was the only site of recurrent disease, whereas the other had lung and brain metastasis at the time of epidural involvement diagnosis.
  • Surgical decompression followed by radiation therapy may result in a complete preservation of the neurologic functions in patients with spinal cord compression secondary to metastatic carcinoma of the uterine cervix.
  • Considering the propensity for disseminated disease, long term survival might be achieved only with the use of effective chemotherapy.
  • [MeSH-major] Epidural Neoplasms / secondary. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery. Uterine Cervical Neoplasms
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / radiotherapy. Adenocarcinoma / secondary. Adult. Brain Neoplasms / secondary. Fatal Outcome. Female. Humans. Laminectomy. Lung Neoplasms / secondary. Lymphatic Metastasis. Middle Aged

  • Genetic Alliance. consumer health - Cervical cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 10733025.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] IRELAND
  •  go-up   go-down


13. Inoue T, Tanaka E, Sakuramoto M, Minakuchi M, Maeda Y, Maniwa K, Terada K, Goto S, Takeda T, Yuba Y, Kobashi Y, Noma S, Taguchi Y: [A case of intramedullary spinal cord metastasis due to small cell lung cancer]. Nihon Kokyuki Gakkai Zasshi; 2004 Dec;42(12):1014-8
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of intramedullary spinal cord metastasis due to small cell lung cancer].
  • Systemic chemotherapy and radiotherapy were performed resulting in complete remission of the disease.
  • Specimen obtained by tumor biopsy showed pathological diagnosis of metastasis from small cell lung cancer.
  • Intramedullary metastasis of lung cancer is very rare, and early diagnosis and multidisciplinary treatment may improve quality of life.
  • [MeSH-major] Carcinoma, Small Cell / secondary. Lung Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Aged. Cervical Vertebrae / pathology. Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging

  • Genetic Alliance. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15678908.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


14. Petridis AK, Hempelmann RG, Hugo HH, Eichmann T, Mehdorn HM: Metastatic low-grade inflammatory myofibroblastic tumor (IMT) in the central nervous system of a 29-year-old male patient. Clin Neuropathol; 2004 Jul-Aug;23(4):158-66
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic low-grade inflammatory myofibroblastic tumor (IMT) in the central nervous system of a 29-year-old male patient.
  • A case of myofibrosarcoma (IMT) of the brain and lung as well as the spinal cord is described.
  • Computer tomography identified a bleeding in the left frontal lobe.
  • The histological examination could not reveal an exact diagnosis.
  • In the CT of the chest a large tumor in the left lower lobe of the lung and additionally a cystic structure in the mediastinum was seen.
  • The histological examination of this tumor identified an inflammatory myofibroblastic tumor (IMT).
  • In the further clinical history the patient developed a large spinal cord metastasis of the thoracic spine.
  • The metastatic development of the tumor reported in this case is unusual.
  • The current therapy of these tumors consists of complete tumor resection and further clinical controls.
  • There is no proven role of chemotherapy and radiation therapy.
  • [MeSH-major] Central Nervous System Neoplasms / secondary. Fibrosarcoma / secondary. Lung Neoplasms / pathology. Neoplasms, Muscle Tissue / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Hemangioma, Cavernous, Central Nervous System / pathology. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Inflammatory myofibroblastic tumor.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15328880.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


15. Ishibashi Y, Tokuchi Y, Kamachi M, Harada M, Isobe H: [A case of non-small-cell lung cancer with intramedullary spinal cord metastasis diagnosed pre-mortem]. Nihon Kokyuki Gakkai Zasshi; 2000 Dec;38(12):943-6
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of non-small-cell lung cancer with intramedullary spinal cord metastasis diagnosed pre-mortem].
  • The patient was a 54-year-old man who in May 1999 received a diagnosis of squamous cell carcinoma, T4 N2 M1, stage IV.
  • Systemic chemotherapy and stereotactic radiosurgery were performed only to result in further progression of the disease.
  • Brain MRI revealed multiple brain metastasis and whole brain irradiation was performed.
  • Later, bladder dysfunction also developed.
  • Since spinal cord MRI revealed intramedullary metastasis at Th 12 and L1 levels, we performed radiotherapy for the lumbar medullary lesion, together with systemic chemotherapy.
  • After chemoradiotherapy the tumor size decreased and the pain improved.
  • Cases of lung cancer with intramedullary metastasis are rare, especially those diagnosed before death.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Lung Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Brain Neoplasms / secondary. Brain Neoplasms / therapy. Combined Modality Therapy. Humans. Magnetic Resonance Imaging. Male. Middle Aged

  • Genetic Alliance. consumer health - Lung Cancer.
  • Genetic Alliance. consumer health - Non-small cell lung cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11244733.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


16. Witwer BP, Salamat MS, Resnick DK: Gliosarcoma metastatic to the cervical spinal cord: case report and review of the literature. Surg Neurol; 2000 Nov;54(5):373-8; discusiion 378-9
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gliosarcoma metastatic to the cervical spinal cord: case report and review of the literature.
  • BACKGROUND: We describe a case of an intramedullary metastasis to the cervical spinal cord from a temporal gliosarcoma.
  • A MRI scan revealed the presence of an intramedullary lesion in the spinal cord behind the body of C2.
  • Despite repeated craniotomy, radiation, and chemotherapy, the patient succumbed to a rapidly progressive disease.
  • We believe this to be the first case report of an intramedullary spinal cord metastasis from a gliosarcoma.
  • [MeSH-major] Brain Neoplasms / pathology. Gliosarcoma / secondary. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / secondary. Temporal Lobe
  • [MeSH-minor] Cervical Vertebrae. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Paresis / etiology

  • Genetic Alliance. consumer health - Gliosarcoma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11165614.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
  •  go-up   go-down


17. Jalali K, Chautard D, Racineux P, Pabot du Chatelard P: [Spinal cord metastasis from prostate cancer]. Prog Urol; 2004 Sep;14(4):554-7; discussion 557
MedlinePlus Health Information. consumer health - Prostate Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spinal cord metastasis from prostate cancer].
  • [Transliterated title] Métastase dans la moelle épinière d'un cancer de la prostate.
  • The majority of spinal cord lesions observed in prostate cancer are related to extradural compression.
  • The authors report a case of probable carcinomatous myelitis secondary to prostate cancer in a 50-year-old man, 9 months after the initial diagnosis of advanced metastatic prostate cancer.
  • Despite endocrine therapy initiated immediately after diagnosis, the patient rapidly developed leg pain due to vertebral osteolysis.
  • He developed flaccid paraplegia despite radiotherapy of the lumbar spine combined with corticosteroid therapy and chemotherapy.
  • Spinal cord magnetic resonance imaging (MRI) showed typical features of very probable carcinomatous myelitis in the cervicothoracic zone.
  • Regardless of the primary cancer, intramedullary spinal cord metastases have a very poor prognosis.
  • [MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Spinal Neoplasms / secondary

  • Genetic Alliance. consumer health - Prostate cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15776912.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


18. Gabriel K, Schiff D: Metastatic spinal cord compression by solid tumors. Semin Neurol; 2004 Dec;24(4):375-83
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic spinal cord compression by solid tumors.
  • As the survival of cancer patients continues to improve, physicians in the 21st century face the challenge of early detection of metastatic spinal cord compression.
  • Prompt diagnosis and intervention increase the likelihood of functional recovery.
  • Because the epidural space is the most common site of spinal cord metastasis from solid tumors, this article will review the epidemiology, relevant anatomy, pathophysiology, clinical presentation, diagnostic evaluation, treatment, and prognosis for metastatic epidural spinal cord compression.
  • Special attention will be given to the various modalities available for management of metastatic epidural spinal cord compression to maintain or restore normal spinal cord function and relieve pain.
  • These treatment options will be considered according to patients' disease burden, life expectancy, and values.
  • Intramedullary metastasis will be briefly discussed.
  • [MeSH-major] Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Cord Neoplasms / complications. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Diagnostic Imaging / methods. Drug Therapy / methods. Humans. Prognosis. Radiotherapy / methods

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15637649.001).
  • [ISSN] 0271-8235
  • [Journal-full-title] Seminars in neurology
  • [ISO-abbreviation] Semin Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
  • [Number-of-references] 65
  •  go-up   go-down


19. Hu E: Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseases. Recent Pat Cardiovasc Drug Discov; 2006 Nov;1(3):249-63

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseases.
  • Recent evidence suggest that targeting Rho protein per se or its downstream effector proteins such as Rho kinase or LIM kinase may have therapeutic potential in diseases such as hypertension, angina, myocardiac infarction (MI), atherosclerosis, tumor metastasis and spinal cord injury.
  • Several recent patents have described modalities that regulate the activity of Rho, Rho kinase and LIM kinase as potential therapeutics.
  • [MeSH-major] Cardiovascular Diseases / drug therapy. Signal Transduction / drug effects. rho-Associated Kinases / antagonists & inhibitors

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18221090.001).
  • [Journal-full-title] Recent patents on cardiovascular drug discovery
  • [ISO-abbreviation] Recent Pat Cardiovasc Drug Discov
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United Arab Emirates
  • [Chemical-registry-number] EC 2.7.11.1 / Lim Kinases; EC 2.7.11.1 / rho-Associated Kinases
  • [Number-of-references] 139
  •  go-up   go-down


20. Kim W, Min CK, Shim YS, Shon YM, Yang DW: Intramedullary spinal cord metastasis of acute lymphoblastic leukemia as the initial manifestation of relapse. Leuk Lymphoma; 2008 Jun;49(6):1214-6
Genetic Alliance. consumer health - Acute Lymphoblastic Leukemia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord metastasis of acute lymphoblastic leukemia as the initial manifestation of relapse.
  • [MeSH-major] Neoplasm Recurrence, Local / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Spinal Cord Neoplasms / etiology
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Male. Muscle Weakness / drug therapy. Muscle Weakness / etiology. Remission Induction

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18569642.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  •  go-up   go-down






Advertisement