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1. Kramer CK, Ferreira N, Silveiro SP, Gross JL, Dora JM, Azevedo MJ: Pituitary gland metastasis from renal cell carcinoma presented as a non-functioning macroadenoma. Arq Bras Endocrinol Metabol; 2010;54(5):498-501
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  • [Title] Pituitary gland metastasis from renal cell carcinoma presented as a non-functioning macroadenoma.
  • Metastatic tumors involving the pituitary gland are an uncommon finding and occur in up to 1% of all pituitary tumor resections.
  • Five years ago, he underwent a right radical nephrectomy for renal cell carcinoma, followed by chemotherapy and radiotherapy for lung and parotid metastases.
  • This case illustrates that metastatic pituitary lesions can mimic typical symptoms and signs of pituitary macroadenoma.
  • Furthermore, clinical diabetes insipidus, a common finding of pituitary metastases, can be absent.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Pituitary Neoplasms / secondary
  • [MeSH-minor] Adenoma / diagnosis. Aged. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 20694412.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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2. Tamer G, Kartal I, Aral F: Pituitary infiltration by non-Hodgkin's lymphoma: a case report. J Med Case Rep; 2009;3:9293

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pituitary infiltration by non-Hodgkin's lymphoma: a case report.
  • INTRODUCTION: Pituitary adenomas represent the most frequently observed type of sellar masses; however, the presence of a rapidly growing sellar tumor, diabetes insipidus, ophthalmoplegia and headaches in an older patient strongly suggests metastasis to the pituitary.
  • Since the anterior pituitary has a great reserve capacity, metastasis to the pituitary and pituitary involvement in lymphoma are usually asymptomatic.
  • As magnetic resonance imaging revealed a sellar mass involving the pituitary gland and infundibular stalk, which also extended into the right cavernous sinus and sphenoid sinus, the patient underwent an immediate transsphenoidal decompression surgery.
  • Paranasal sinus computed tomography scanning and magnetic resonance imaging of the thorax and abdomen were performed.
  • Since magnetic resonance imaging did not reveal any abnormality, after paranasal sinus computed tomography was performed, we concluded that the primary lymphoma originated from the sphenoid sinus and infiltrated the pituitary.
  • Chemotherapy and radiotherapy to the sellar area were planned, but the patient died and her family did not permit an autopsy.
  • CONCLUSION: Lymphoma infiltration to the pituitary is difficult to differentiate from pituitary adenoma, meningioma and other sellar lesions.
  • To plan the treatment of lymphoma infiltration of the pituitary gland, it must be differentiated from other sellar lesions.

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  • (PMID = 20062782.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803816
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3. Azambuja E, Piccart MJ, Awada A: Long-term survival in pituitary metastasis from breast cancer. Breast; 2006 Jun;15(3):446-7
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  • [Title] Long-term survival in pituitary metastasis from breast cancer.
  • We report the interesting case of a patient who is a long-term survivor of breast cancer with metastasis to the pituitary gland.
  • This patient was treated with surgery and radiotherapy in 1995 and during her second relapse, which occurred in 2004, chemotherapy was given.
  • This treatment resulted in a partial response.
  • [MeSH-major] Breast Neoplasms / pathology. Pituitary Neoplasms / mortality. Pituitary Neoplasms / secondary. Survivors
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Magnetic Resonance Imaging. Middle Aged


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4. Gunn GB, Villa RD, Sedler RR, Hardwicke F, Fornari GA, Mark RJ: Nasopharyngeal carcinoma metastasis to the pituitary gland: a case report and literature review. J Neurooncol; 2004 May;68(1):87-90
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  • [Title] Nasopharyngeal carcinoma metastasis to the pituitary gland: a case report and literature review.
  • While nasopharyngeal carcinoma (NPC) commonly invades the skull base, true central nervous system metastasis is a rare phenomenon.
  • We report a case of NPC metastasis to the pituitary gland and review the literature for similar events.
  • Eight months after his definitive radiation therapy, our patient presented with symptoms of optic chiasm compression and panhypopituitarism.
  • Medical imaging revealed a pituitary mass but demonstrated no evidence of skull base erosion or direct intracranial extension.
  • Subsequent biopsy of the pituitary lesion was confirmed as NPC in origin with Epstein-Barr virus-encoded RNA in-situ hybridization studies.
  • The patient was treated with high dose chemotherapy followed by autologous stem cell transplant, which produced short-term symptomatic relief and at least a 7 month survival.
  • [MeSH-major] Nasopharyngeal Neoplasms / secondary. Pituitary Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Epstein-Barr Virus Infections / pathology. Epstein-Barr Virus Infections / therapy. Herpesvirus 4, Human / isolation & purification. Humans. In Situ Hybridization. Male. Middle Aged. RNA Probes. RNA, Viral / genetics. RNA, Viral / metabolism. Stem Cell Transplantation. Transplantation, Autologous

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  • (PMID = 15174525.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / RNA Probes; 0 / RNA, Viral
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5. Tomoda Y, Kai T, Inata J, Miyazaki K, Murai H, Yamaoka N, Kuraoka T: [Central diabetes insipidus caused by pituitary metastasis of lung cancer]. Nihon Kokyuki Gakkai Zasshi; 2005 Dec;43(12):751-4
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  • [Title] [Central diabetes insipidus caused by pituitary metastasis of lung cancer].
  • After examination, lung cancer (adenocarcinoma T1NOM1, Stage IV) and central diabitus insipidus caused by pituitary metastasis of lung cancer, were diagnosed.
  • We gave him desmopressin acetate, gamma knife surgery for pituitary metastasis and chemotherapy with paclitaxel and carboplatin, and his symptoms improved.
  • However, his lung cancer progressed.
  • Diabitus insipidus caused by lung cancer is rare.
  • [MeSH-major] Adenocarcinoma / secondary. Diabetes Insipidus, Neurogenic / etiology. Lung Neoplasms / pathology. Pituitary Neoplasms / secondary
  • [MeSH-minor] Aged. Antidiuretic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / administration & dosage. Combined Modality Therapy. Deamino Arginine Vasopressin / therapeutic use. Humans. Male. Paclitaxel / administration & dosage. Radiosurgery. Taxoids / administration & dosage


6. Fassett DR, Couldwell WT: Metastases to the pituitary gland. Neurosurg Focus; 2004 Apr 15;16(4):E8
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  • [Title] Metastases to the pituitary gland.
  • Only 1% of all pituitary surgeries are performed to treat tumors that have metastasized to the pituitary gland; however, in certain cases of malignant neoplasms pituitary metastases do occur.
  • Breast and lung cancers are the most common diseases that metastasize to the pituitary.
  • Breast cancer metastasizes to the pituitary especially frequently, with reported rates ranging between 6 and 8% of cases.
  • Most pituitary metastases are asymptomatic, with only 7% reported to be symptomatic.
  • Diabetes insipidus, anterior pituitary dysfunction, visual field defects, headache/pain, and ophthalmoplegia are the most commonly reported symptoms.
  • Differentiation of pituitary metastasis from other pituitary tumors based on neuroimaging alone can be difficult, although certain features, such as thickening of the pituitary stalk, invasion of the cavernous sinus, and sclerosis of the surrounding sella turcica, can indicate metastasis to the pituitary gland.
  • Overall, neurohypophysial involvement seems to be most prevalent, but breast metastases appear to have an affinity for the adenohypophysis.
  • Differentiating metastasis to the pituitary gland from bone metastasis to the skull base, which invades the sella turcica, can also be difficult.
  • In metastasis to the pituitary gland, surrounding sclerosis in the sella turcica is usually minimal compared with metastasis to the skull base.
  • Treatment for these tumors is often multimodal and includes surgery, radiation therapy, and chemotherapy.
  • [MeSH-major] Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / secondary
  • [MeSH-minor] Combined Modality Therapy. Diagnostic Imaging / methods. Humans. Prognosis. Treatment Outcome

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  • (PMID = 15191337.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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7. Taniguchi H, Inomata M, Abo H, Miyazawa H, Noto H, Izumi S: [Central diabetes insipidus caused by pituitary metastasis of lung cancer]. Nihon Kokyuki Gakkai Zasshi; 2004 Dec;42(12):1009-13
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  • [Title] [Central diabetes insipidus caused by pituitary metastasis of lung cancer].
  • Large cell lung cancer T3N2M1 (Stage IV), and central diabetes insipidus caused by pituitary metastasis of lung cancer, were diagnosed.
  • We gave him desmopressin acetate, and chemotherapy with paclitaxel and carboplatin.
  • But pituitary metastasis increased and invaded the hypothalamus.
  • After irradiation of the pituitary and hypothalamus, metastatic focus diminished and desmopressin acetate was tapered.
  • [MeSH-major] Carcinoma, Large Cell / secondary. Diabetes Insipidus / etiology. Lung Neoplasms / pathology. Pituitary Neoplasms / secondary
  • [MeSH-minor] Humans. Male. Middle Aged. Pituitary Irradiation


8. Nasr C, Mason A, Mayberg M, Staugaitis SM, Asa SL: Acromegaly and somatotroph hyperplasia with adenomatous transformation due to pituitary metastasis of a growth hormone-releasing hormone-secreting pulmonary endocrine carcinoma. J Clin Endocrinol Metab; 2006 Dec;91(12):4776-80
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  • [Title] Acromegaly and somatotroph hyperplasia with adenomatous transformation due to pituitary metastasis of a growth hormone-releasing hormone-secreting pulmonary endocrine carcinoma.
  • Hypothalamic gangliocytomas producing GHRH are also known to be associated with pituitary adenomas causing acromegaly.
  • OBJECTIVES: The objective of this study was to describe a case of acromegaly due to a pulmonary GHRH-secreting endocrine carcinoma with metastasis to the pituitary gland and to look at the peculiar histological features of this case.
  • SUBJECT: The patient was a 44-yr-old woman who was diagnosed with a biopsy-proven metastatic pulmonary endocrine tumor during pregnancy.
  • After delivery, she underwent radiation and chemotherapy for pulmonary and skeletal metastases.
  • Her disease was clinically stable for 7 yr until she developed bitemporal hemianopia.
  • Histological examination confirmed metastatic endocrine carcinoma to the pituitary, and immunohistochemistry localized GHRH to the tumor cells.
  • The adjacent pituitary exhibited somatotroph hyperplasia with abundant reactivity for GH and alpha-subunit.
  • CONCLUSION: This is the first report of a GHRH-producing endocrine tumor metastasizing to the pituitary and causing local hyperstimulation with somatotroph hyperplasia and adenomatous transformation.
  • [MeSH-major] Acromegaly / complications. Acromegaly / etiology. Adenoma / etiology. Carcinoma / complications. Growth Hormone-Releasing Hormone / secretion. Lung Neoplasms / complications. Paraneoplastic Endocrine Syndromes / complications. Pituitary Neoplasms / secondary. Somatotrophs / pathology

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  • (PMID = 16968791.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hormones, Ectopic; 0 / Indium Radioisotopes; 9034-39-3 / Growth Hormone-Releasing Hormone
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9. Gur C, Lalazar G, Salmon A, Dubiner V, Gross DJ: Metastatic pancreatic neuroendocrine tumor presenting as a pituitary space occupying lesion: a case report. Pituitary; 2008;11(3):293-7
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  • [Title] Metastatic pancreatic neuroendocrine tumor presenting as a pituitary space occupying lesion: a case report.
  • Neuroendocrine tumor metastases to the pituitary gland are very rare.
  • There are few case reports of carcinoid tumor metastases to the pituitary, but no cases of pancreatic neuroendocrine pituitary metastases have been reported.
  • In this report we present a 55-year-old female with a sellar mass, ophthalmoplegia and headaches initially thought to represent an invasive null cell pituitary adenoma.
  • However a histological (trans-sphenoidal and liver biopsies) and systemic investigation proved it to be a metastasis of an undiagnosed pancreatic neuroendocrine tumor.
  • Our patient was unique in respect to the location of the metastasis and the uncharacteristically high proliferative index of her tumor.
  • She received conventional therapy consisting of Sandostatin, chemotherapy and radiotherapy as well as labeled somatostatin following an avid uptake on octreotide scanning.
  • [MeSH-major] Neuroendocrine Tumors / secondary. Pancreatic Neoplasms / pathology. Pituitary Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Fatal Outcome. Female. Humans. Middle Aged. Radiotherapy, Adjuvant. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 17638085.001).
  • [ISSN] 1386-341X
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Erbetta A, Salmaggi A, Sghirlanzoni A, Silvani A, Potepan P, Botturi A, Ciceri E, Bruzzone MG: Clinical and radiological features of brain neurotoxicity caused by antitumor and immunosuppressant treatments. Neurol Sci; 2008 Jun;29(3):131-7
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  • [Title] Clinical and radiological features of brain neurotoxicity caused by antitumor and immunosuppressant treatments.
  • Antitumor and immunosuppressant treatment-related neurotoxicity can determine nonspecific clinical syndromes.
  • We report clinical and neuroradiological features in five patients with neurotoxic syndromes due to chemotherapy/radiotherapy or immunosuppression in the context of neoplastic disease/organ transplantation.
  • Acute neurological syndrome developed in three patients after methotrexate (MTX), cyclosporine A, and L-asparaginase therapy, respectively.
  • Late onset clinical syndrome occurred in the last two patients, treated with MTX or radiation therapy for breast cancer metastasis and pituitary adenoma.
  • Patients affected by tumors suffer from increased risk for treatment-related toxicities.
  • Appearance or worsening of neurological signs and symptoms challenge the clinician to discriminate between CNS involvement by the tumor, toxicity of drugs, parane-oplastic disease and infections.
  • MRI has a key role in differential diagnosis.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Brain / drug effects. Brain / pathology. Immunosuppressive Agents / adverse effects. Neurotoxicity Syndromes / pathology
  • [MeSH-minor] Adult. Aged. Asparaginase / adverse effects. Cerebral Veins / drug effects. Cerebral Veins / pathology. Cerebral Veins / physiopathology. Child. Cyclosporine / adverse effects. Diagnosis, Differential. Female. Graft Rejection / drug therapy. Humans. Liver Transplantation / adverse effects. Magnetic Resonance Imaging. Male. Methotrexate / adverse effects. Middle Aged. Neoplasms / surgery. Neoplasms / therapy. Paraneoplastic Syndromes, Nervous System / diagnosis. Radiotherapy / adverse effects. Risk Factors. Venous Thrombosis / chemically induced

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  • (PMID = 18612759.001).
  • [ISSN] 1590-1874
  • [Journal-full-title] Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
  • [ISO-abbreviation] Neurol. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine; EC 3.5.1.1 / Asparaginase; YL5FZ2Y5U1 / Methotrexate
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11. Tanaka H, Kobayashi A, Bando M, Hosono T, Tsujita A, Yamasawa H, Ohno S, Hironaka M, Sugiyama Y: [Case of small cell lung cancer complicated with diabetes insipidus and Cushing syndrome due to ectopic adrenocorticotropic hormone secretion]. Nihon Kokyuki Gakkai Zasshi; 2007 Oct;45(10):793-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case of small cell lung cancer complicated with diabetes insipidus and Cushing syndrome due to ectopic adrenocorticotropic hormone secretion].
  • A 54-year-old woman had been given a diagnosis with scleroderma and interstitial pneumonia due to scleroderma when she was 45 years old.
  • Small-cell lung cancer (metastases in the pituitary, subcutaneous tissue, and lungs) was diagnosed by transbronchial lung biopsy and subcutaneous nodule biopsy of the abdomen.
  • The final diagnosis was diabetes insipidus and Cushing syndrome.
  • Chemotherapy was done with CDDP and VP-16, which resulted in reduction of the tumor and improvement in endocrinological findings.
  • Nevertheless, chemotherapy could not be continued because of infected bullae.
  • We concluded that this case was Cushing syndrome caused by ectopic adrenocorticotropic hormone-producing small cell lung cancer, and that it presented with diabetes insipidus because of pituitary metastasis.
  • Therefore, when drastic endocrinological changes are found, it is important to examine for cancer, including lung cancer, as soon as possible.
  • [MeSH-minor] Fatal Outcome. Female. Humans. Middle Aged. Pituitary Neoplasms / secondary


12. Granata A, Viola G, Privitera C, Romeo G, Cacciaguerra S, Gaeta M, Sicurezza E, Figuera M: Smoking, polyuria and impaired vision. Clin Nephrol; 2007 Jan;67(1):49-52
MedlinePlus Health Information. consumer health - Smoking.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pituitary gland can be involved in a variety of medical conditions, including metastatic tumors.
  • Metastases to the pituitary gland, although absolutely rare, more commonly affect the posterior pituitary lobe and so frequently present with diabetes insipidus.
  • Computed tomography (CT) scan of the brain showed a mass located in the sella turcica and in the suprasellar region.
  • The patient received radiotherapy on the pituitary gland and adjuvant chemotherapy, and as intrasellar and suprasellar mass decreased in size, urinary output was accordingly reduced.
  • Therefore, is that in patients with risk factors for cancer and sudden onset of diabetes insipidus pituitary metastasis should be taken into account in differential diagnosis.
  • [MeSH-major] Adenocarcinoma / secondary. Diabetes Insipidus, Neurogenic / etiology. Hemianopsia / etiology. Lung Neoplasms / pathology. Pituitary Neoplasms / secondary. Polyuria / etiology. Smoking / adverse effects

  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • MedlinePlus Health Information. consumer health - Pituitary Tumors.
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  • (PMID = 17269600.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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13. Irifune K, Hamada H, Yokoyama A, Kondo K, Kohno N, Hara Y, Hiwada K: [A case of central diabetes insipidus caused by metastatic small cell lung cancer]. Nihon Kokyuki Gakkai Zasshi; 2002 Feb;40(2):154-9
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of central diabetes insipidus caused by metastatic small cell lung cancer].
  • MRI films revealed tumorous swelling of the pituitary stalk.
  • Central diabetes insipidus caused by pituitary metastasis of small cell lung cancer was diagnosed.
  • After treatment with whole-brain irradiation and chemotherapy, the size of the swollen pituitary stalk was reduced and his urine volume decreased.
  • He died of respiratory insufficiency 15 months after the initial diagnosis.
  • No recurrence of pituitary metastasis was apparent.
  • This was a rare case of central diabetes insipidus caused by pituitary metastasis of small cell lung cancer successfully treated with radiotherapy and chemotherapy.


14. Granata A, Figura M, Gulisano S, Romeo G, Sicurezza E, Failla A, Scuderi R: [Central diabetes insipidus as a first manifestation of lung adenocarcinoma]. Clin Ter; 2007 Nov-Dec;158(6):519-22
MedlinePlus Health Information. consumer health - Pituitary Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pituitary gland and infundibulum can be involved in a variety of medical conditions, including infiltrative diseases, fungal infections, tuberculosis, primary and metastatic tumors.
  • Metastases to the pituitary gland are absolutely rare, and they are generally secondary to pulmonary carcinoma in men and breast carcinoma in women.
  • Pituitary metastases more commonly affect the posterior lobe and the infundibulum than the anterior lobe.
  • The posterior lobe involvement may explain why patients with pituitary metastases frequently present with diabetes insipidus.
  • Computed tomography (CT) scan of the brain showed a mass located in the sella turcica and suprasellar region.
  • Thus, we made a diagnosis of lung cancer with local and pituitary metastases.
  • The patient received radiotherapy on the pituitary gland and adjuvant chemotherapy.
  • In conclusion, in patients presenting with sudden onset of diabetes insipidus pituitary metastases should be taken in account in differential diagnosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Diabetes Insipidus / etiology. Lung Neoplasms / diagnosis. Pituitary Neoplasms / complications. Pituitary Neoplasms / secondary
  • [MeSH-minor] Biopsy. Bronchoscopy. Diagnosis, Differential. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Middle Aged. Polyuria / etiology. Thirst. Tomography, X-Ray Computed


15. Peppa M, Papaxoinis G, Xiros N, Raptis SA, Economopoulos T, Hadjidakis D: Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer: a case report and review of the literature. Clin Breast Cancer; 2009 Nov;9(4):E4-7
MedlinePlus Health Information. consumer health - Pituitary Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Panhypopituitarism due to metastases to the hypothalamus and the pituitary resulting from primary breast cancer: a case report and review of the literature.
  • Pituitary metastasis occurs rarely in cancer patients and often remains undiagnosed.
  • However, early detection and appropriate treatment can improve the patient's quality of life and possibly prolong survival.
  • Herein, we describe the case of a 52-year-old woman with panhypopituitarism caused by metastases to the hypothalamus and pituitary from primary breast cancer.
  • She had a 5-year history of breast cancer with metastases to the bones 1.5 years after initial diagnosis and mastectomy.
  • Laboratory work-up revealed panhypopituitarism (central diabetes insipidus; hypothyroidism; and low prolactin, gonadotrophin, and adrenocorticotropic hormone levels), and magnetic resonance imaging confirmed the pituitary and hypothalamic involvement.
  • She received hormone replacement therapy, radiation therapy of the sella turcica and suprasellar lesion, and chemotherapy, with significant improvement of her clinical status, but she died 15 months later.
  • [MeSH-major] Breast Neoplasms / pathology. Hypopituitarism / etiology. Hypothalamic Neoplasms / secondary. Pituitary Neoplasms / secondary


16. Dogan M, Karakilic E, Oz II, Zorlu F, Akbulut H: Breast cancer with diabetes insipidus. Exp Oncol; 2008 Dec;30(4):324-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast cancer with diabetes insipidus.
  • Diabetes insipidus (DI) is a rare clinical condition, which is usually caused by neurohypophyseal or pituitary stalk infiltration in cancer patients.
  • CASE REPORT: we present a 62-year old metastatic breast cancer woman with DI.
  • She admitted to the hospital because of nausea, vomiting, polyuria and polydipsia, while she was on no cytotoxic medication.
  • The CT scan of the brain yielded a suspicious area in pituitary gland.
  • A pituitary stalk metastasis was found on magnetic resonance imaging (MRI) of pituitary.
  • CONCLUSIONS: Cancer patients who have symptoms such as nausea, vomiting, polyuria and polydipsia while they are not on chemotherapy should be evaluated for not only metabolic complications like hypercalcemia but also posterior pituitary or stalk metastasis MRI could be the choice of imaging for pituitary metastasis.
  • [MeSH-major] Breast Neoplasms / pathology. Diabetes Insipidus / etiology. Pituitary Neoplasms / complications. Pituitary Neoplasms / secondary


17. Hoellig A, Niehusmann P, Flacke S, Kristof RA: Metastasis to pituitary adenoma: case report and review of the literature. Cent Eur Neurosurg; 2009 Aug;70(3):149-53
MedlinePlus Health Information. consumer health - Pituitary Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis to pituitary adenoma: case report and review of the literature.
  • We present a rare case of a metastasis to a pituitary adenoma and review 14 cases published in the literature to date.
  • Metastases to pituitary adenomas most commonly present with rapidly progressing chiasm compression syndromes, headaches and oculomotor nerve palsies.
  • Metastases to pituitary adenomas have to be considered in the differential diagnosis of sellar tumors.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / pathology. ACTH-Secreting Pituitary Adenoma / secondary. Pituitary Neoplasms / pathology. Pituitary Neoplasms / secondary
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Fatal Outcome. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology. Magnetic Resonance Imaging. Male. Neoplasm Metastasis / pathology. Oculomotor Nerve / pathology. Ophthalmoplegia / etiology. Small Cell Lung Carcinoma / pathology. Tomography, X-Ray Computed

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  • [Copyright] Georg Thieme Verlag KG Stuttgart New York.
  • (PMID = 19701874.001).
  • [ISSN] 1868-4912
  • [Journal-full-title] Central European neurosurgery
  • [ISO-abbreviation] Cent Eur Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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