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Items 1 to 12 of about 12
1. Kodama M, Kawaguchi H, Komoto Y, Takemura M: Coexistent intramedullary spinal cord and choroidal metastases in ovarian cancer. J Obstet Gynaecol Res; 2010 Feb;36(1):199-203
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  • [Title] Coexistent intramedullary spinal cord and choroidal metastases in ovarian cancer.
  • Involvement of intramedullary spinal cord and the choroid by ovarian cancer is rare, and coexistence of metastases at these sites is extremely rare and has never been reported.
  • This condition rapidly progresses to a neurological emergency; however, an efficient standard treatment method is not available for this rare condition.
  • She presented with blindness and other neurologic complaints during the course of treatment for a recurrence at 50 months after the primary surgical treatment for the tumor.
  • Magnetic resonance imaging (MRI) revealed intramedullary spinal cord metastasis and choroidal metastasis, coexisting with multiple brain metastases and intra-abdominal lesions.
  • Neurological emergency was prevented by administering whole-brain irradiation therapy followed by systemic chemotherapy.
  • Early diagnosis and multidisciplinary treatment, including radiotherapy and chemotherapy, may offer good palliation for such unusual metastases of ovarian cancer.
  • [MeSH-major] Brain Neoplasms / secondary. Choroid Neoplasms / secondary. Cystadenocarcinoma, Serous / secondary. Neoplasm Recurrence, Local. Ovarian Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Abdominal Neoplasms / secondary. Abdominal Neoplasms / therapy. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Hysterectomy. Ovariectomy

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  • (PMID = 20178552.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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2. Ino K, Mitsui T, Nomura S, Kikkawa F, Mizutani S: Complete remission of gestational choriocarcinoma with choroidal metastasis treated with systemic chemotherapy alone: case report and review of literature. Gynecol Oncol; 2001 Dec;83(3):601-4
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  • [Title] Complete remission of gestational choriocarcinoma with choroidal metastasis treated with systemic chemotherapy alone: case report and review of literature.
  • BACKGROUND: Gestational choriocarcinoma is a malignant tumor that frequently metastasizes to the highly vascularized organs such as the lung, brain, and liver via hematogenous spread.
  • However, this tumor rarely metastasizes to the eye and only a few cases of metastasis to the choroid have been reported.
  • Ophthalmologic evaluation revealed a metastatic choroidal tumor, and a CT scan showed a metastatic tumor in the left lung.
  • A clinical diagnosis of metastatic gestational choriocarcinoma involving the choroid and lung was made.
  • The patient received 13 courses of combination chemotherapy, resulting in complete remission.
  • Radiotherapy and surgical treatment were unnecessary.
  • CONCLUSION: This is a very rare case of the successful treatment of gestational choriocarcinoma metastatic to the choroid using systemic chemotherapy alone.
  • [MeSH-major] Choriocarcinoma / drug therapy. Choriocarcinoma / secondary. Choroid Neoplasms / drug therapy. Choroid Neoplasms / secondary. Uterine Neoplasms / drug therapy

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  • [Copyright] (c)2001 Elsevier Science.
  • (PMID = 11733980.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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3. Sari R, Camci C, Kutlu R, Totan Y, Sevinc A, Buyukberber S: The efficacy of acetazolamide on visual functions in a patient with choroid metastasis of breast carcinoma. Int J Clin Pract; 2001 Sep;55(7):488-90
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  • [Title] The efficacy of acetazolamide on visual functions in a patient with choroid metastasis of breast carcinoma.
  • Breast carcinoma is the most frequent cancer in women and is the second leading cause of death.
  • Choroid metastasis of breast carcinoma can be found either at presentation or in remission.
  • It is frequently encountered in disseminated breast cancer with multiple organ metastasis.
  • It has been proposed that the oedema-reducing effect of acetazolamide is due to stimulated ion and fluid removal from the retina to the choroid.
  • A 40-year-old female patient on adjuvant chemotherapy for breast cancer was found to have an isolated choroid metastasis.
  • Clinical and radiological remission was achieved after orbital radiotherapy, chemotherapy and acetazolamide treatment.
  • In this case report, we emphasise the possible beneficial effect of acetazolamide in patients with choroid metastasis.
  • [MeSH-major] Acetazolamide / therapeutic use. Breast Neoplasms. Carbonic Anhydrase Inhibitors / therapeutic use. Carcinoma, Ductal, Breast / secondary. Choroid Neoplasms / secondary. Vision Disorders / drug therapy

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  • (PMID = 11594263.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; O3FX965V0I / Acetazolamide
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4. Inoue K, Numaga J, Kaji Y, Toda J, Kato S, Sakurai M, Ikeda M, Motoi N, Murakami T, Fujino Y: Bilateral choroidal metastases secondary to uterocervical carcinoma of the squamous cell type. Am J Ophthalmol; 2000 Nov;130(5):682-4
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  • [Title] Bilateral choroidal metastases secondary to uterocervical carcinoma of the squamous cell type.
  • PURPOSE: To report a patient with bilateral choroidal metastases secondary to uterocervical carcinoma of the squamous cell type.
  • Seven months earlier, uterocervical carcinoma of the squamous cell type was diagnosed and treated with chemotherapy and irradiation.
  • Serous retinal detachment and choroidal masses were present in both eyes.
  • The patient died of respiratory insufficiency 3 months after the appearance of choroidal metastases.
  • At autopsy, there was no second cancer to cause the choroidal metastases.
  • Tumor embolization was present in the choriocapillaries.
  • CONCLUSION: Choroidal metastasis may develop from hematogenous spread of uterocervical squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Choroid Neoplasms / secondary. Uterine Cervical Neoplasms / pathology


5. Piccinin MR, Almeida JA Jr, Aydos RD, Nogueira DC, Silva RF: [Choroid metastasis of testicular primary site: case report]. Arq Bras Oftalmol; 2006 Nov-Dec;69(6):949-53
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  • [Title] [Choroid metastasis of testicular primary site: case report].
  • [Transliterated title] Met├ístases de cor├│ide de origem testicular: relato de caso.
  • Description of a male patient case, 22 years old, presenting visual acuity decrease in the left eye associated with the diagnosis of metastatic testicular tumor to lung and kidney.
  • Evaluation of the evolution of a choroid lesion compatible with ocular metastasis of testis tumor through ophthalmologic and echographic examinations.
  • There was resolution of the intraocular lesion together with lung radiologic improvement after chemotherapy during approximately 4 months of follow-up.
  • In spite of the remission of the ocular lesion, the patient died due to complications of cerebral metastasis.
  • Approached in the literature as rare, no report was found of a case of choroidal metastasis of a testicular site, this being, perhaps, its first description.
  • [MeSH-major] Choroid Neoplasms / secondary. Seminoma / secondary. Testicular Neoplasms
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Fatal Outcome. Humans. Lung Neoplasms / secondary. Male

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  • (PMID = 17273696.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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6. George B, Wirostko WJ, Connor TB, Choong NW: Complete and durable response of choroid metastasis from non-small cell lung cancer with systemic bevacizumab and chemotherapy. J Thorac Oncol; 2009 May;4(5):661-2
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  • [Title] Complete and durable response of choroid metastasis from non-small cell lung cancer with systemic bevacizumab and chemotherapy.
  • Ocular metastasis from lung cancer is uncommon.
  • We report a patient with metastatic non-small cell lung cancer who was found to have a metastatic lesion in the choroid at the time of presentation.
  • After three cycles of chemotherapy, radiologic imaging and ophthalmologic examination demonstrated complete resolution of the choroid lesion.
  • This case report demonstrates the durable response of choroidal metastasis from non-small cell lung cancer to systemic bevacizumab and chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Choroid Neoplasms / drug therapy. Lung Neoplasms / drug therapy
  • [MeSH-minor] Adult. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Bevacizumab. Carboplatin / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Female. Humans. Prognosis. Treatment Outcome

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  • (PMID = 19395911.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0W860991D6 / Deoxycytidine; 2S9ZZM9Q9V / Bevacizumab; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin
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7. Schmidt D, Ness T, Geissler M: Cotton-wool spots associated with pancreatic carcinoma. Eur J Med Res; 2001 Mar 26;6(3):101-4
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  • BACKGROUND: Malignant tumors of different organs may cause changes in the eye.
  • In addition, the man revealed a metastasis of the choroid in the right eye.
  • The cotton-wool spots were reduced in size in the woman after treatment with Gemcitabine.
  • After termination of treatment, their general condition deteriorated and they died within a few weeks.
  • [MeSH-minor] Adrenal Gland Neoplasms / drug therapy. Adrenal Gland Neoplasms / secondary. Biomarkers, Tumor / metabolism. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Eye Neoplasms / diagnosis. Eye Neoplasms / drug therapy. Eye Neoplasms / secondary. Fatal Outcome. Female. Humans. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Lymphatic Metastasis / pathology. Male. Middle Aged

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  • (PMID = 11309222.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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8. Giganti M, Beer PM, Lemanski N, Hartman C, Schartman J, Falk N: Adverse events after intravitreal infliximab (Remicade). Retina; 2010 Jan;30(1):71-80
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  • PURPOSE: To determine the tolerability of intravitreal infliximab (Remicade) in patients with refractory diabetic macular edema or choroidal neovascularization secondary to age-related macular degeneration.
  • METHODS: This is a prospective, interventional, noncomparative, open-label, 12-week pilot study of intravitreal infliximab in four patients who failed conventional therapies.
  • Two had diabetic macular edema and two had choroidal neovascularization secondary to age-related macular degeneration.
  • All patients received 0.5 mg/0.05 mL intravitreal infliximab and were eligible for a second injection at 6 weeks if reinjection criteria were met.
  • Outcome measures were best-corrected visual acuity using standard Early Treatment Diabetic Retinopathy Study refraction, central retinal thickness on optical coherence tomography, fluorescein angiography, standard electroretinography, and microperimetry.
  • All patients had persistence of cystoid macular edema on optical coherence tomography, although two had a decrease in central retinal thickness.
  • The first patient entered in the study met the criteria for a second injection because of improved standard electroretinography and microperimetry at Week 6.
  • However, 2 weeks after the second injection, he developed panuveitis.
  • Three patients developed systemic antibodies against infliximab (human antichimeric antibodies).
  • [MeSH-major] Anti-Inflammatory Agents / adverse effects. Antibodies, Anti-Idiotypic / blood. Antibodies, Monoclonal / adverse effects. Panuveitis / chemically induced. Retina / drug effects
  • [MeSH-minor] Aged. Chimera / immunology. Choroidal Neovascularization / drug therapy. Choroidal Neovascularization / etiology. Diabetic Retinopathy / complications. Diabetic Retinopathy / drug therapy. Electroretinography. Female. Fluorescein Angiography. Follow-Up Studies. Humans. Infliximab. Injections. Macular Degeneration / complications. Macular Degeneration / drug therapy. Macular Edema / drug therapy. Macular Edema / etiology. Male. Middle Aged. Pilot Projects. Prospective Studies. Tomography, Optical Coherence. Tumor Necrosis Factor-alpha / antagonists & inhibitors. Tumor Necrosis Factor-alpha / immunology. Visual Acuity / physiology. Visual Field Tests. Vitreous Body

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  • (PMID = 19996827.001).
  • [ISSN] 1539-2864
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antibodies, Anti-Idiotypic; 0 / Antibodies, Monoclonal; 0 / Tumor Necrosis Factor-alpha; B72HH48FLU / Infliximab
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9. Venkatesh P, Garg S: Regression of choroidal metastasis from breast carcinoma following Letrozole therapy. Clin Exp Ophthalmol; 2007 Jul;35(5):492-4
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  • [Title] Regression of choroidal metastasis from breast carcinoma following Letrozole therapy.
  • Metastasis to the choroid from primary tumours elsewhere in the body is not an infrequent occurrence.
  • Management of such metastasis may involve modalities such as radiotherapy, chemotherapy, photocoagulation and surgical resection.
  • The role of hormonal therapy is poorly defined in the management of these tumours.
  • Herein regression of choroidal metastasis from primary breast carcinoma following antihormonal therapy with the antioestrogen drug Letrozole is reported.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Breast Neoplasms / drug therapy. Choroid Neoplasms / drug therapy. Estrogen Receptor Modulators / therapeutic use. Nitriles / therapeutic use. Triazoles / therapeutic use
  • [MeSH-minor] Adult. Female. Fluorescein Angiography. Humans. Remission Induction. Tomography, Optical Coherence

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  • (PMID = 17651258.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Estrogen Receptor Modulators; 0 / Nitriles; 0 / Triazoles; 7LKK855W8I / letrozole
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10. Soysal HG: Metastatic tumors of the uvea in 38 eyes. Can J Ophthalmol; 2007 Dec;42(6):832-5
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  • [Title] Metastatic tumors of the uvea in 38 eyes.
  • BACKGROUND: The reported incidence of metastatic uveal tumors has been increasing.
  • The aim of this study is to report the clinical features, management, and prognosis of uveal metastatic tumors seen in a general oncology hospital.
  • METHODS: The records of 28 patients with uveal metastasis diagnosed between 1999 and 2006 were reviewed retrospectively.
  • RESULTS: Uveal metastatic tumours were detected in a total of 38 eyes, uveal involvement included the iris in 4 eyes and the choroid in 37 eyes.
  • The primary cancer site was the breast in 24 patients, the lung in 2 patients, the ovary in 1 patient, and the gastrointestinal tract in 1 patient.
  • Choroidal metastases typically were creamy yellow in color, plateau or dome-shaped, and associated with secondary retinal detachment in 56.8% of eyes.
  • The mean time interval between ocular and systemic diagnosis was 41.07 months.
  • At the time of ocular diagnosis, 75% of patients had systemic metastasis.
  • Eight eyes were treated with chemotherapy and hormone therapy, and external beam radiotherapy was applied to 30 eyes.
  • Lesions commonly responded well to therapy, but 22 patients died as a result of disseminated systemic disease.
  • INTERPRETATION: Patients with uveal metastasis generally present to ophthalmologists with visual symptoms but may be asymptomatic in some cases.
  • Local tumor control can be managed with current therapy, but systemic prognosis is generally poor because of the disseminated stage of the malignant disease.

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  • (PMID = 17985001.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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11. ElMallah MK, Chernoff AM, Blair NP: Testicular mixed germ-cell tumor metastatic to the choroid. Retin Cases Brief Rep; 2008;2(2):172-4
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  • [Title] Testicular mixed germ-cell tumor metastatic to the choroid.
  • PURPOSE: To describe the fundus findings, ultrasonography, and fluorescein angiography of a testicular mixed germ-cell tumor metastatic to the choroid and to report prompt resolution of the choroidal lesion with systemic chemotherapy.
  • A 21-year-old man presented with a 10-cm testicular tumor.
  • Ophthalmic examination revealed a large, dome-shaped choroidal lesion in the left eye, filling the entire superotemporal quadrant and extending into the macula.
  • RESULTS: On ophthalmic examination 6 weeks after initiation of chemotherapy, the choroidal lesion had completely resolved, leaving only pigmentary changes.
  • Final ophthalmology follow-up 8 months after presentation demonstrated no recurrence of choroidal metastases.
  • CONCLUSION: Testicular germ-cell tumors have now been well described to metastasize to the choroid.
  • These choroidal metastases can show a prompt, favorable response to chemotherapy.

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  • (PMID = 25389834.001).
  • [ISSN] 1935-1089
  • [Journal-full-title] Retinal cases & brief reports
  • [ISO-abbreviation] Retin Cases Brief Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Kociecki J, Biczysko W, Alugail AW: [Secondary retinal detachment accompanying intraocular tumors]. Klin Oczna; 2004;106(1-2):39-44
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  • [Title] [Secondary retinal detachment accompanying intraocular tumors].
  • PURPOSE: Aim of the study--the attempt to answer, what is the present incidence mechanism of arising, and what parameters can influence the development of secondary retinal detachment (s. r. d.) caused by intraocular choroidal tumor.
  • MATERIAL AND METHOD: 107 eyes of 105 consecutive patients aged 21 to 82 years (mean 62 years), diagnosed clinically as having choroidal malignant tumor, were evaluated.
  • The cause of s. r. d. was primary malignant choroidal tumor and in 3 cases--metastatic tumor.
  • The therapy included brachytherapy, diode laser transpupillary thermotherapy (TTT), chemotherapy, local tumor excision and combined treatment.
  • The s. r. d. was observed in cases of small tumors (2.77 mm) as well as very large ones (up to 11.56 mm).
  • After therapy the detachment conceded in 10 eyes (37%).
  • Analysis of clinical images, fluorescein angiograms and histopathological evaluation enabled better understanding of mechanisms leading to s. r. d.
  • In evaluated group the s. r. d. occurred more often in women (62%) than in men (38%).
  • 3. The s. r. d. may occur in large tumors (over 6 mm) as well as in small ones (3 mm).
  • 4. In case of large tumors the detachment has mainly "mechanical" character, however it may be also influenced by increased permeability of tumor vessels and impaired function of retinal pigment epithelium; the latter mechanism seems to play the main role in case of small tumors; in both cases the external retinal layer is damaged.
  • 5. The most common cause of s. r. d. are tumors located in posterior pole (45%) and least frequently in upper-temporal quadrant (7%).
  • 6. After brachytherapy, TTT or local tumor excision in selected cases s. r. d. may totally regress.
  • [MeSH-major] Choroid Neoplasms / complications. Retina / pathology. Retinal Detachment / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Incidence. Male. Middle Aged. Poland / epidemiology

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  • (PMID = 15218763.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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