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1. Ishizu K, Hirata H, Yano S, Naito K, Furuya T, Muratani T, Kobayashi T: [Tuberculous epididymitis caused by intravesical BCG therapy: a case report]. Hinyokika Kiyo; 2003 Sep;49(9):539-42

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  • [Title] [Tuberculous epididymitis caused by intravesical BCG therapy: a case report].
  • A 67-year-old man had received trasuretheral resection for bladder cancer in February 1997.
  • Under the diagnosis of benign prostatic hypertrophy, transuretheral resection of the prostate was performed in March 1998.
  • Multiple tuberculous nodules were histopathologically detected in resected prostatic tissues.
  • The nodule developed during 6 weeks, with spontaneous perforation of the scrotal skin and discharge of pus.
  • Drug therapy for 3 months with rifampicin, isoniazid and ethambutol was initiated in September 2001, and right orchiectomy was performed in October.
  • [MeSH-minor] Administration, Intravesical. Aged. Carcinoma, Transitional Cell / drug therapy. Carcinoma, Transitional Cell / surgery. Humans. Male. Urinary Bladder Neoplasms / drug therapy. Urinary Bladder Neoplasms / surgery

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  • (PMID = 14598693.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / BCG Vaccine
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2. Tanase K, Tawada M, Moriyama N, Muranaka K: [Intra-arterial infusion chemotherapy for liver metastases of testicular tumors: report of two cases]. Hinyokika Kiyo; 2000 Nov;46(11):823-7
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  • [Title] [Intra-arterial infusion chemotherapy for liver metastases of testicular tumors: report of two cases].
  • Two cases of testicular tumors with lymph node involvement and multiple lung and liver metastases were treated successfully with intra-arterial infusion chemotherapy.
  • Case 1: A 30-year-old man presented with right scrotal swelling and an abdominal mass.
  • Histopathological diagnosis revealed embryonal cell carcinoma and choriocarcinoma.
  • Cisplatin, vinblastine, VP-16 and pepleomycin combination chemotherapy (PVeBV) was started and repeated for 2 courses.
  • Systemic and intrahepatic arterial infusion combined with chemotherapy was administered, and intra-arterial chemotherapy (cisplatin, VP-16) was added.
  • The patient also received systemic chemotherapy (carboplatin, VP-16, ifosfamide).
  • After chemotherapy, retroperitoneal lymph node dissection was performed.
  • Microscopic examination revealed no viable cancer cells.
  • Case 2: A 43-year-old man presented with right scrotal swelling and an abdominal mass.
  • Histopathological diagnosis revealed seminoma.
  • Cisplatin, vinblastine, VP-16 and pepleomycin combination chemotherapy (PVeBV) was administered, but the liver tumors ware enlarged on CT scan.
  • Intrahepatic arterial infusion chemotherapy (cisplatin, VP-16) was started and repeated for 4 courses.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Embryonal / secondary. Choriocarcinoma / secondary. Liver Neoplasms / secondary. Seminoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Infusions, Intra-Arterial. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Neoplasms, Multiple Primary. Treatment Outcome. Vinblastine / administration & dosage

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  • (PMID = 11193306.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; PVeBV protocol
  • [Number-of-references] 13
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3. Matsumoto H, Nakane H, Aoki A, Naito K, Imate Y, Ohkami K, Isoyama R: [A case of synchronous cervical lymph node metastases from testicular and thyroid cancers showing mixed response to chemotherapy]. Hinyokika Kiyo; 2000 Jul;46(7):505-8
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  • [Title] [A case of synchronous cervical lymph node metastases from testicular and thyroid cancers showing mixed response to chemotherapy].
  • We report a case of synchronous presentation of thyroid cancer and testicular seminoma with lymph node metastasis.
  • A 37-year-old man presented with right scrotal swelling and multiple lymph node swelling.
  • After systemic work-up for staging, we diagnosed the patient with multiple lymph node metastasis of the seminoma, and administered three cycles of bleomycin, etoposide, and cisplatin (BEP) therapy.
  • Although the chemotherapy was very effective for the retroperitoneal and left cervical lymph node metastases, the right cervical tumor did not change.
  • Pathological examination of the thyroid revealed papillary thyroid cancer and its right cervical lymph node metastasis.
  • There was no evidence of viable cancer cells from either of the primary cancers in the retroperitoneal lymph node.
  • Unresponsiveness to chemotherapy for metastatic lesions from testicular cancer might be a useful clue to detect primary tumors of other origins.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Papillary / drug therapy. Lymph Nodes / pathology. Neoplasms, Multiple Primary. Seminoma / drug therapy. Testicular Neoplasms / drug therapy. Thyroid Neoplasms / drug therapy
  • [MeSH-minor] Adult. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Etoposide / administration & dosage. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Orchiectomy. Thyroidectomy. Treatment Outcome

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  • (PMID = 10965461.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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4. Shoji S, Shima M, Usui Y, Nagata Y, Uchida T, Terachi T: [A case report: simultaneous bilateral testicular tumors with different cell types--complete response after combination chemotherapy of cisplatin and irrinotecan hydrochloride--]. Hinyokika Kiyo; 2006 Apr;52(4):303-6
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  • [Title] [A case report: simultaneous bilateral testicular tumors with different cell types--complete response after combination chemotherapy of cisplatin and irrinotecan hydrochloride--].
  • A 38-year-old man was admitted to our hospital complaining of bilateral scrotal swelling.
  • Histopathological examination of the excised tumors revealed seminoma, embryonal carcinoma, yolk sac tumor and immature teratoma in the right testis and seminoma in the left testis.
  • The patient was treated postoperatively with two courses of BEP (bleomycin, etoposide, cisplatin) therapy and two courses of EP (etoposide, cisplatinum) therapy.
  • The patient had lung metastasis during the follow-up period and we treated him with salvage combination chemotherapy of cisplatin and irinotecan hydrochloride (CPT-11).
  • After the third course of cisplatin and CPT-11 chemotherapy the lung metastasis disappeared and we performed retroperitoneal lymph node dissection.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Endodermal Sinus Tumor / drug therapy. Neoplasms, Multiple Primary. Salvage Therapy. Seminoma / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adult. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Humans. Lung Neoplasms / secondary. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Remission Induction

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  • (PMID = 16686361.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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5. Schmidt OA, Stahl U, Brueck M: [Posthepatic obstructive jaundice caused by primary extragonadal germ-cell tumor in a patient with glucose-6-phosphatase dehydrogenase deficiency]. Dtsch Med Wochenschr; 2010 Nov;135(44):2181-5
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  • [Transliterated title] Posthepatische Cholestase infolge primär-extragonadaler Manifestation eines Keimzelltumors bei einem Patienten mit Favismus.
  • HISTORY AND ADMISSION FINDINGS: In patients with glucose-6-phosphatase dehydrogenase (G6PD) deficiency (favism) jaundice is usually caused by hemolysis due to stress, infection or following the application of drugs.
  • Scrotal examination by palpation and ultrasound showed no abnormalities.
  • THERAPY AND COURSE: After successful stent-implantation by PTC with decompression of the biliary tree, the jaundice disappeared.
  • Computer tomography-guided percutaneous biopsy of a retroperitoneal lymph node was performed for histological evaluation showing a primary extragonadal nonseminomatous germ cell tumor.
  • According to the histology (embryonic carcinoma) and clinical stage of the tumor systemic chemotherapy was initiated including cisplatin, etoposide and ifosfamide.
  • After the first cycle of chemotherapy the patient suffered from pneumonia leading to septic shock.
  • CONCLUSION: Extragonadal germ-cell tumor presenting as retroperitoneal lymph nodes with obstructive jaundice has to be considered in the differential diagnosis of cholestasis.
  • [MeSH-major] Cholestasis, Extrahepatic / diagnosis. Common Bile Duct Neoplasms / diagnosis. Favism / diagnosis. Glycogen Storage Disease Type I / diagnosis. Jaundice, Obstructive / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis
  • [MeSH-minor] Aged. Biopsy. Cholangiography. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Male

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20979002.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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6. Ando R, Yasui T, Tozawa K, Sasaki S, Hayashi Y, Kohri K: Testicular seminoma occurring 8 years after treatment of a metastatic extragonadal germ cell tumor. Int J Urol; 2007 Jan;14(1):85-6
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  • [Title] Testicular seminoma occurring 8 years after treatment of a metastatic extragonadal germ cell tumor.
  • A 30-year-old man was admitted with a chief complaint of left-sided scrotal enlargement, and was diagnosed as having testicular seminoma after orchiectomy.
  • Eight years earlier, he had been treated with chemotherapy for an extragonadal germ cell tumor, without orchiectomy, leading to complete remission.
  • His histological diagnosis at that time was a germ cell tumor, composed of choriocarcinoma and embryonal carcinoma.
  • Routine pretreatment testicular biopsy in patients with extragonadal germ cell tumor is controversial, but regular long-term follow up and information on the risk of developing a metachronous testicular tumor are needed after treatment of extragonadal germ cell tumors, even when there seems to be a partial or complete clinical response.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Second Primary / diagnosis. Seminoma / diagnosis. Testicular Neoplasms / diagnosis. Testicular Neoplasms / drug therapy

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  • (PMID = 17199868.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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7. Aki FT, Bilen CY, Tekin MI, Ozen H: Is scrotal violation per se a risk factor for local relapse and metastases in stage I nonseminomatous testicular cancer? Urology; 2000 Sep 1;56(3):459-62
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  • [Title] Is scrotal violation per se a risk factor for local relapse and metastases in stage I nonseminomatous testicular cancer?
  • OBJECTIVES: To determine the risk of local recurrence and relapse in patients with Stage I nonseminomatous testicular cancer with scrotal violation.
  • METHODS: From 1983 to 1998, 75 patients with clinical Stage I nonseminomatous testicular cancer who were initially treated with orchiectomy and surveillance alone were retrospectively reviewed.
  • RESULTS: Of 75 patients with Stage I nonseminomatous testicular cancer, 13 had scrotal violation.
  • Five patients (38%) in the scrotal violation group and 17 patients (27%) in the inguinal orchiectomy group experienced relapses.
  • All relapses, except one in the standard inguinal orchiectomy group, were treated successfully with chemotherapy and postchemotherapy surgery, if needed.
  • CONCLUSIONS: Scrotal violation without positive surgical margins and tumor spillage does not adversely affect relapse rate and survival.
  • Therefore, scrotal violation per se is not an exclusion criterion for the surveillance-only policy in patients with Stage I nonseminomatous testicular germ cell cancer.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / surgery. Scrotum / surgery. Testicular Neoplasms / surgery

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  • (PMID = 10962315.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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8. Yildirim Y, Akcay Y, Ozyilkan O, Celasun B: Prostate small cell carcinoma and skin metastases: a rare entity. Med Princ Pract; 2008;17(3):250-2
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  • [Title] Prostate small cell carcinoma and skin metastases: a rare entity.
  • OBJECTIVES: To report a rare case of small cell carcinoma of the prostate with unusual skin metastasis.
  • Abdominal computed tomography scans revealed a prostatic mass invading the surrounding tissues and multiple perirectal, periprostatic, para-aortic and pericaval lymph nodes.
  • Needle biopsy specimens showed both small cell carcinoma and adenocarcinoma.
  • He was treated with combination chemotherapy: cisplatin and etoposide and bilateral orchiectomy.
  • After six cycles of the chemotherapy, disease progressed and the patient did not respond to salvage therapy; hence, palliative care was instituted.
  • During the follow-up, papillary lesions were observed in the scrotal skin; biopsy showed metastatic small cell carcinoma.
  • CONCLUSION: Small cell carcinoma of the prostate is an aggressive disease with a highly metastatic potential; but skin metastases are very uncommon.
  • It has poor prognosis despite therapy.
  • Management resembles that of small cell carcinoma of the lung.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / secondary. Prostatic Neoplasms / pathology. Skin Neoplasms / secondary

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18408396.001).
  • [ISSN] 1423-0151
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin
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9. Opot EN, Magoha GA: Testicular cancer at Kenyatta National Hospital, Nairobi. East Afr Med J; 2000 Feb;77(2):80-5
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  • [Title] Testicular cancer at Kenyatta National Hospital, Nairobi.
  • OBJECTIVE: To determine the prevalence, clinical characteristics, management methods and prognosis of testicular cancer at Kenyatta National Hospital.
  • DESIGN: Retrospective case study of testicular cancer patients over a fifteen year period.
  • PARTICIPANTS: All histologically confirmed testicular cancer patients recorded at the Histopathology Department of Kenyatta National Hospital between 1983 and 1997.
  • Thirty one patients (79.49%) presented with painless testicular swellings, eleven (28.08%) with pain, nine (23.08%) with scrotal heaviness, six (15.38%) with abdominal swellings and one (2.56%) each with gynaecomastia and eye swelling.
  • More than eighty nine per cent had germ cell cancers with seminoma accounting for 67.35%, teratoma 12.24%, embroyonal carcinoma 8.16%, rhabdomyosarcoma 6.12% and malignant germ cell tumour, orchioblastoma and dysgerminoma each accounted for 2.04%.
  • Three patients (7.7%) had orchidectomy and radiotherapy and chemotherapy, sixteen (41.03%) had orchidectomy and radiotherapy, six (15.38%) had orchidectomy and chemotherapy, ten (25.64%) had radiotherapy and chemotherapy, three (7.7%) and two (5.13%) had only chemotherapy and radiotherapy respectively.
  • No cisplastin based chemotherapy regime was used.
  • Cisplastin based chemotherapy with up to 90% cure rates should be included as a component of testicular cancer management at Kenyatta National Hospital.
  • This retrospective study was undertaken to determine the prevalence, clinical characteristics, management methods and prognosis of testicular cancer at Kenyatta National Hospital, Nairobi.
  • All histologically confirmed testicular cancer patients recorded at the Histopathology Department between 1993 and 1997 were analyzed.
  • The clinical symptoms presented were painless testicular swelling (n = 31, 79.49%), testicular pain (n = 11, 28.08%), scrotal heaviness (n = 9, 23.08%), abdominal swelling (n = 6, 15.38%), gynecomastia (n = 1, 2.56%), and eye swelling (n = 1, 2.56%).
  • More than 89% of patients had germ cell cancers with seminoma accounting for 67.35%, teratoma for 12.24%, embryonal carcinoma for 8.16%, rhabdomyosarcoma for 6.12%, and malignant germ cell tumor, orchioblastoma, and dysgerminoma each accounting for 2.04%.
  • The various methods of treatment include orchidectomy and radiotherapy and chemotherapy in 3 patients (7.7%), orchidectomy and radiotherapy in 16 patients (41.03%), orchidectomy and chemotherapy in 6 patients (15.38%), and radiotherapy and chemotherapy in 10 patients (25.64%).
  • No cisplatin-based chemotherapy was used.
  • Hence, cisplatin-based chemotherapy with up to 90% cure rates should be included in the testicular cancer management in this hospital.
  • [MeSH-major] Testicular Neoplasms / diagnosis. Testicular Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Child. Child, Preschool. Combined Modality Therapy. Hospitals, Teaching. Humans. Incidence. Kenya / epidemiology. Male. Middle Aged. Orchiectomy. Prognosis. Referral and Consultation. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 10774080.001).
  • [ISSN] 0012-835X
  • [Journal-full-title] East African medical journal
  • [ISO-abbreviation] East Afr Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] KENYA
  • [Other-IDs] PIP/ 149564; POP/ 00296083
  • [Keywords] PIP ; Cancer (major topic) / Clinical Research (major topic) / Prevalence (major topic) / Research Report (major topic) / Retrospective Studies (major topic) / Signs And Symptoms (major topic) / Testis (major topic) / Treatment (major topic) / Africa / Africa South Of The Sahara / Biology / Developing Countries / Diseases / Eastern Africa / English Speaking Africa / Genitalia / Genitalia, Male / Kenya / Measurement / Neoplasms / Physiology / Research Methodology / Studies / Urogenital System
  • [General-notes] PIP/ TJ: EAST AFRICAN MEDICAL JOURNAL.
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10. Ishida M, Hasegawa M, Kanao K, Oyama M, Nakajima Y: Non-palpable testicular embryonal carcinoma diagnosed by ultrasound: a case report. Jpn J Clin Oncol; 2009 Feb;39(2):124-6
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  • [Title] Non-palpable testicular embryonal carcinoma diagnosed by ultrasound: a case report.
  • With the extensive use of scrotal ultrasound (US), incidental non-palpable testicular tumors have thus been unexpectedly discovered.
  • Radical orchiectomy was performed and histological examinations confirmed a diagnosis of a mixed tumor of seminoma and embryonal carcinoma.
  • Systemic chemotherapy was introduced immediately, and the serum level of AFP decreased to the normal range and the metastatic lesions had disappeared after three courses of the chemotherapy.
  • No recurrence was observed at 18 months follow-up after the chemotherapy.
  • This is the first case of non-palpable testicular embryonal carcinoma, which metastasized soon after the resection.
  • The obscurity and implications of such a diagnosis are also discussed.
  • [MeSH-major] Carcinoma, Embryonal / ultrasonography. Testicular Neoplasms / ultrastructure

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  • (PMID = 19066212.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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11. Gohji K, Watsuji T, Ubai T, Ueda H, Katsuoka Y: Embryonal carcinoma of the testis associated with prostate cancer in a 72-year-old man. Int J Urol; 2001 Dec;8(12):719-21
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  • [Title] Embryonal carcinoma of the testis associated with prostate cancer in a 72-year-old man.
  • A 72-year-old Japanese man presented with a painless swollen left scrotal mass with elevated levels of serum alpha-fetoprotein and prostate specific antigen.
  • The patient underwent high orchiectomy under diagnosis and a final pathological examination revealed embryonal carcinoma of the left testis.
  • A systematic needle prostate biopsy under guidance of transrectal ultrasound revealed prostate cancer (Gleason score, 8) on the left lobe (T2aN0M0).
  • Systemic chemotherapy was given for retroperitoneal lymph node metastasis of testicular cancer and hormonal therapy (LH-RH analog) was given for prostate cancer.
  • The patient was well with no evidence of metastasis from the testicular cancer or prostate cancer and with no elevation of serum alpha-fetoprotein or prostate specific antigen 26 months after the orchiectomy.
  • [MeSH-major] Carcinoma, Embryonal / secondary. Prostatic Neoplasms / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Aged. Gonadotropin-Releasing Hormone / therapeutic use. Humans. Lymphatic Metastasis. Male. Orchiectomy. Prostate-Specific Antigen

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  • (PMID = 11851777.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 33515-09-2 / Gonadotropin-Releasing Hormone; EC 3.4.21.77 / Prostate-Specific Antigen
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12. Chintamani, Shankar M, Singhal V, Singh JP, Bansal A, Saxena S: Squamous cell carcinoma developing in the scar of Fournier's gangrene--case report. BMC Cancer; 2004 Apr 27;4:16
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  • [Title] Squamous cell carcinoma developing in the scar of Fournier's gangrene--case report.
  • BACKGROUND: Squamous cell carcinoma of the scrotum is rare and its development in the scar of Fournier's gangrene is still rarer.
  • CASE PRESENTATION: A 65-year-old gentleman presented with a small non-healing ulcer developing on right hemi-scrotum two years after the treatment for Fournier's gangrene.
  • On histological examination it was found to be squamous cell carcinoma.
  • He was successfully managed by surgery in the form of wide local excision and ilio-inguinal lymph node dissection followed by adjuvant radiotherapy and chemotherapy.
  • CONCLUSIONS: Squamous cell carcinoma can develop in the scar of Fournier's gangrene after a long delay, which differentiates it from other scar carcinomas or Marjolin's ulcer.
  • [MeSH-major] Carcinoma, Squamous Cell / etiology. Fournier Gangrene / complications. Genital Neoplasms, Male / etiology. Scrotum

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  • [Cites] Hinyokika Kiyo. 2000 Oct;46(10):735-7 [11215202.001]
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  • (PMID = 15113443.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC411041
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13. Hamid AR, Umbas R: Metastasis of testicular carcinoma in the inguinal region. Acta Med Indones; 2009 Jan;41(1):25-9
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  • [Title] Metastasis of testicular carcinoma in the inguinal region.
  • A standard protocol for the management of inguinal metastasis from testicular cancer still has not yet been established.
  • Metastasis of testicular cancer to inguinal lymph node rarely occurs, particularly in patients without any prior surgery in inguinal and scrotal region.
  • Daugaard reported 2% incidence of inguinal metastasis for stage 1 testicular cancer in 5-year period.
  • We reported a case of inguinal metastasis from residual testicular cancer with a large size of mass.
  • For this case, surgical treatment of residual tumor excision had been performed prior to the chemotherapy considering a quite large size of tumor mass, which may easily bleed and causing anemia to the patient.
  • Furthermore, we considered that chemotherapy treatment prior to surgical excision will only provide partial effect on the tumor.
  • After the surgery, a 4-cycle combined chemotherapy was administered despite the delay of chemotherapy treatment resulting in residual mass in inguinal region.
  • In fact, the post-surgical chemotherapy treatment in this case has demonstrated relatively good response.
  • [MeSH-major] Carcinoma, Embryonal / secondary. Choriocarcinoma / secondary. Endodermal Sinus Tumor / secondary. Seminoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Fatal Outcome. Groin. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Neoplasm, Residual. Skin Transplantation

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  • (PMID = 19258677.001).
  • [ISSN] 0125-9326
  • [Journal-full-title] Acta medica Indonesiana
  • [ISO-abbreviation] Acta Med Indones
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Indonesia
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14. Saito J, Takayama H, Kakuta Y, Miyagawa Y, Tsujihata M, Nishimura K, Nonomura N, Okuyama A: [The growing teratoma syndrome report of a case]. Nihon Hinyokika Gakkai Zasshi; 2006 Sep;97(6):796-800
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  • A 26-year-old man presented with a swelling of the right scrotal content, lumbago and exertional dyspnea.
  • A single course of BEP (bleomysin, etoposide and cisplatin), two courses of chemotherapy consisting of nedaplatin and irinotecan, and three courses of TIP (paclitaxel, ifosfamide and cisplatin) were delivered.
  • He is alive for 49 months after high inguinal orchiectomy and free of carcinoma.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Combined Modality Therapy. Drug Administration Schedule. Etoposide / administration & dosage. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Orchiectomy. Remission Induction

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  • (PMID = 17025213.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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15. Hagiuda J, Matsumoto M, Hanawa Y, Ishikawa H, Marumo K: [Adenocarcinoma of the rete testis. A case report]. Nihon Hinyokika Gakkai Zasshi; 2010 Nov;101(7):749-53
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  • The diagnosis is often difficult and made incidentally.
  • Our patient was an 80-year-old man who presented with painless scrotal swelling for 2 years.
  • Physical examination revealed an enlarged, hard mass of the left scrotum.
  • After 4 months, the patient presented with appetite loss, general fatigue, and pain in the left scrotum.
  • Positron emission tomography (PET) was performed in another hospital, and the patient was referred for a left testicular tumor, multiple lung metastases, and para-aorta lymph node metastasis.
  • Pathological examination revealed a hard whitish mass around the testis involving the epididymis and tunica vaginalis and spreading under the subcutaneous tissue.
  • Histological examination revealed adenocarcinoma in the hilum of the testis, which extended to the subcutaneous tissue but not to the surface of the scrotum.
  • The tunica albuginea was intact, and no invasion of carcinoma in the testis was seen.
  • After the histological diagnosis of adenocarcinoma of the rete testis was confirmed, computed tomography (CT) was performed and showed multiple pulmonary nodules and para-aortica lymph node swelling of 3 cm diameter.
  • Because the patient did not wish to receive chemotherapy or other aggressive treatment, he has been followed-up with palliative care since his diagnosis.
  • Although local recurrence has occurred 4 months later, he is still alive for 8 months since his diagnosis.
  • [MeSH-major] Adenocarcinoma / therapy. Testicular Neoplasms / therapy
  • [MeSH-minor] Aged, 80 and over. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Orchiectomy. Palliative Care. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 21174741.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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16. Fedorov VD, Odariuk TS, Shelygin IuA: [Long-term result of hemicorporectomy]. Khirurgiia (Mosk); 2000;(2):9-13

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  • The patient was operated several times since 1983 for massive perianal condylomas.
  • In 1985 the ulcer with hard edges was revealed in the perianal region, spreading to the perineum and root of the scrotum.
  • Biopsy data evidenced for epidermoid carcinoma Abdominoperineal extirpation of the rectum was carried out with broad dissection of the skin of the perineum and with resection of the seminal follicle.
  • Postoperative period was complicated by prolonged pyogenous infection of the perineal wound which prevented from radiation treatment.
  • 6 courses of chemotherapy by 5-fluorouracyl were carried out.
  • During the process of examination in September 1987 in the perineal area a large massive tumor occupying the whole pelvic cavity and growing into the posterior wall of the urine bladder and left ishial bone, spreading to the scrotal root and surrounded by the net of fistulous tracts was revealed.
  • Thus, in spite of a number of complications we can state, that hemicorporectomy has cured the patient of advanced, cancer and he feels satisfied with this treatment and saving 12 years of life.
  • [MeSH-major] Amputation / methods. Carcinoma, Squamous Cell / surgery. Pelvic Neoplasms / surgery
  • [MeSH-minor] Adult. Decision Making. Follow-Up Studies. Humans. Male. Middle Aged. Prostheses and Implants. Retrospective Studies

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  • (PMID = 10710911.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] RUSSIA
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17. Shigehara K, Kobori Y, Amano T, Takemae K: [Bilateral tuberculous epididymitis after intravesical Bacillus Calmette-Guerin therapy]. Hinyokika Kiyo; 2005 Dec;51(12):839-42
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  • [Title] [Bilateral tuberculous epididymitis after intravesical Bacillus Calmette-Guerin therapy].
  • A 72-year-old man received transuretheral resection of bladder transitional cell carcinoma in November 2000.
  • After the second BCG instillation (160 mg) he had bilateral painful scrotal swelling.
  • Although he was administered isoniazid (INH) and rifampicin (RFP), scrotal swelling got worse.
  • Histological diagnosis was bilateral tuberculous epididymitis.
  • [MeSH-minor] Administration, Intravesical. Aged. Carcinoma, Transitional Cell / therapy. Combined Modality Therapy. Drug Therapy, Combination. Humans. Isoniazid / administration & dosage. Male. Orchiectomy. Rifampin / administration & dosage. Urinary Bladder Neoplasms / therapy

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  • (PMID = 16440736.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / BCG Vaccine; V83O1VOZ8L / Isoniazid; VJT6J7R4TR / Rifampin
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18. Minamide M, Hosoi I, Yanagi S: [CA19-9-producing testicular tumor: a case report]. Hinyokika Kiyo; 2000 Jan;46(1):45-7
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  • A 37-year-old male who had complained of high fever and right scrotal swelling was referred to our department.
  • Ultrasonography and computed tomography demonstrated a right testicular tumor with right lung metastasis and aortocaval lymph node metastasis.
  • The histopathological diagnosis was mixed type of teratoma, yolk sac tumor, embryonal carcinoma and seminoma.
  • Immuno-histochemical analysis showed CA19-9 to be expressed in the cancer cells.
  • After 5 courses of combination chemotherapy, the operation for right lung metastasis was performed.
  • [MeSH-major] Biomarkers, Tumor / analysis. CA-19-9 Antigen / analysis. Carcinoma, Embryonal / diagnosis. Endodermal Sinus Tumor / diagnosis. Neoplasms, Multiple Primary. Seminoma / diagnosis. Teratoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Humans. Male. Orchiectomy. Treatment Outcome. Vinblastine / administration & dosage

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  • (PMID = 10723665.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; Q20Q21Q62J / Cisplatin; PVB protocol
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19. Li Q, Gao T, Jiao B, Qi X, Long HA, Qiao H, Wang L, Lv Y, Hu X, Liao W, Wang S, Li C: Long-term follow-up of in situ extramammary Paget's disease in Asian skin types IV/V treated with photodynamic therapy. Acta Derm Venereol; 2010 Mar;90(2):159-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term follow-up of in situ extramammary Paget's disease in Asian skin types IV/V treated with photodynamic therapy.
  • Photodynamic therapy is a potentially advantageous treatment for non-melanoma skin cancers.
  • We evaluated the clinical response, recurrence and adverse events of photodynamic therapy for in situ extramammary Paget's disease in 14 male and 3 female Chinese patients with 21 lesions.
  • Each lesion was irradiated with 633 nm red light three times, 1 week apart, at a total dose of 339 J/cm2, followed by three assessments at 6, 12 and 24 months.
  • The CR rate was significantly higher in scrotal lesions (66.6%) than in non-scrotal lesions (8.3%).
  • In conclusion, photodynamic therapy for extramammary Paget's disease is not recommended as the first option except for scrotal cases or lesions < 4 cm in diameter.
  • [MeSH-major] Aminolevulinic Acid / administration & dosage. Asian Continental Ancestry Group. Carcinoma in Situ / drug therapy. Paget Disease, Extramammary / drug therapy. Penile Neoplasms / drug therapy. Photochemotherapy. Photosensitizing Agents / administration & dosage. Skin Neoplasms / drug therapy
  • [MeSH-minor] Administration, Cutaneous. Aged. Aged, 80 and over. Chi-Square Distribution. China / epidemiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Patient Satisfaction. Prospective Studies. Recurrence. Scrotum / pathology. Time Factors. Treatment Outcome

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  • (PMID = 20169299.001).
  • [ISSN] 1651-2057
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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20. Stroomer JW, Roos JC, Sproll M, Quak JJ, Heider KH, Wilhelm BJ, Castelijns JA, Meyer R, Kwakkelstein MO, Snow GB, Adolf GR, van Dongen GA: Safety and biodistribution of 99mTechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients. Clin Cancer Res; 2000 Aug;6(8):3046-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety and biodistribution of 99mTechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients.
  • The CD44 protein family consists of isoforms, encoded by standard exons and up to nine alternatively spliced variant exons (v2-v10), which are expressed in a tissue-specific way.
  • Expression of v6-containing variants (CD44v6) has been related to aggressive behavior of various tumor types and was shown to be particularly high in squamous cell carcinoma (SCC).
  • Therefore, CD44v6 might be a suitable target for radioimmunoscintigraphy (RIS) and therapy.
  • RIS results obtained 21 h after injection were compared with palpation, computed tomography, and magnetic resonance imaging, with histopathology as the gold standard.
  • No drug-related adverse events were observed.
  • Besides activity uptake in tumor tissue, minimal accumulation of activity was observed in mouth, lungs, spleen, kidney, bone marrow, and scrotal area.
  • Analysis of tissue biopsies revealed high uptake in tumors, with a mean value of 14.2+/-8.4% of the injected dose/kg tumor tissue and a mean tumor:blood ratio of 2.0+/-1.4 at 40 h after injection.
  • [MeSH-major] Antibodies, Monoclonal / adverse effects. Antigens, CD44 / immunology. Carcinoma, Squamous Cell / metabolism. Glycoproteins / immunology. Head and Neck Neoplasms / metabolism. Immunoconjugates / adverse effects. Immunoconjugates / pharmacokinetics. Radiopharmaceuticals / adverse effects. Radiopharmaceuticals / pharmacokinetics. Technetium
  • [MeSH-minor] Adult. Aged. Antibodies, Neoplasm / blood. Female. Humans. Immunohistochemistry. Male. Middle Aged. Radioimmunodetection. Tissue Distribution

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  • (PMID = 10955783.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Neoplasm; 0 / Antigens, CD44; 0 / CD44v6 antigen; 0 / Glycoproteins; 0 / Immunoconjugates; 0 / Radiopharmaceuticals; 7440-26-8 / Technetium
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21. Thanakit V, Nelson SD, Udomsawaengsup S: Round cell liposarcoma of scrotum with indolent course in young adult. J Med Assoc Thai; 2005 Sep;88(9):1302-7
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  • [Title] Round cell liposarcoma of scrotum with indolent course in young adult.
  • Both myxoid and round cell types share clinical, histological features and are accepted to represent a spectrum of lesions ranging from pure myxoid to near completely round cell liposarcoma.
  • Most masses within the scrotal sac arise from the testis proper, and less likely from the extratesticular tissue.
  • Myxoid/round cell liposarcoma and round cell liposarcoma are rarely encounter in extratesticular soft tissue.
  • We reported a rare case of round cell liposarcoma (high grade myxoid liposarcoma) of extratesticular tissue.
  • To our knowledge, this is the first case of a large size (> 5cm) round cell liposarcoma arising from soft tissue within the scrotal sac of young adult with indolent course.
  • Simple excision or enucleation are inadequate therapies and wide excision of the hemiscrotum including inguinal soft tissue and nodes is recommended.
  • The role of retroperitoneal lymph node dissection and adjuvant chemotherapy remains controversial.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Liposarcoma, Myxoid / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Prognosis. Scrotum / pathology. Testicular Hydrocele / pathology

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  • (PMID = 16536120.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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22. Subramanian VS, Gilligan T, Klein EA: A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance. Nat Clin Pract Urol; 2008 Apr;5(4):220-3
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  • [Title] A case of spermatic cord teratoma in low-stage testicular cancer managed by surveillance.
  • A scrotal ultrasound scan showed a right testicular mass, suspicious for neoplasm.
  • The patient underwent right inguinal orchiectomy and was diagnosed with nonseminomatous germ cell tumor of the right testis, composed of yolk sac tumor, teratoma, and embryonal carcinoma with no evidence of metastatic disease.
  • He opted to remain under surveillance rather than undergo primary chemotherapy or retroperitoneal lymph node dissection for his clinical stage I disease.
  • Serologic relapse at 4 months after orchiectomy was successfully treated with bleomycin, etoposide and cisplatin (BEP) chemotherapy.
  • DIAGNOSIS: A 1.7 cm nodule anterior to the right psoas muscle suspicious for metastatic disease that was seen on CT 16 months after orchiectomy was pathologically confirmed as recurrent mature teratoma in the spermatic cord.
  • [MeSH-major] Genital Neoplasms, Male / therapy. Neoplasms, Germ Cell and Embryonal / surgery. Spermatic Cord / pathology. Teratoma / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chorionic Gonadotropin / blood. Disease Management. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local / therapy. Orchiectomy. alpha-Fetoproteins / analysis

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  • (PMID = 18268549.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / alpha-Fetoproteins
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23. Gemmel C, Jacek G, Lücking HC, Rebel M, Spiethoff A, Schilling D, Riemann JF: [Scrotal abscess with inguinal lymph node swelling in an 86-year-old man]. Dtsch Med Wochenschr; 2004 Sep 24;129(39):2032-4
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  • [Title] [Scrotal abscess with inguinal lymph node swelling in an 86-year-old man].
  • [Transliterated title] Skrotalabszess mit inguinaler Lymphknotenschwellung bei einem 86-jährigen Patienten.
  • HISTORY AND ADMISSION FINDINGS: An 86-year-old patient presented to our clinic with increasing redness and swelling of the right scrotum and inguinal lymphadenopathy.
  • Five and a half years before admission carcinoma of the bladder (pT1,G2) had been diagnosed and was treated with several transurethral endoscopic resections as well as repeated instillations of Bacille Calmette-Guérin (BCG) into the bladder.
  • DIAGNOSIS, TREATMENT AND COURSE: Tuberculostatic therapy was started soon after surgery.
  • After seven weeks of treatment no more mycobacteria could be detected in sputum and urine control specimens.
  • This is a rare complication with potentially serious consequences and requires rapid diagnosis and urgent treatment by a multidisciplinary team.
  • [MeSH-minor] Aged. Aged, 80 and over. Antitubercular Agents / therapeutic use. Bacteriuria / microbiology. Groin. Humans. Lymph Nodes / pathology. Male. Orchiectomy. Sputum / microbiology. Testis / microbiology. Testis / pathology. Tuberculosis, Pulmonary / drug therapy. Tuberculosis, Pulmonary / etiology. Urinary Bladder Neoplasms / therapy

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  • (PMID = 15386205.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / BCG Vaccine
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24. Bulbul MA, Hijaz A, Beaini M, Araj GF, Tawil A: Tuberculous epididymo-orchitis following intravesical BCG for superficial bladder cancer. J Med Liban; 2002 Jan-Apr;50(1-2):67-9
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  • [Title] Tuberculous epididymo-orchitis following intravesical BCG for superficial bladder cancer.
  • A seventy-two-year-old man with transitional cell carcinoma of the bladder received intravesical Bacillus Calmette-Guérin (BCG) following which he developed left testicular pain and swelling that partially resolved with conservative treatment.
  • Ten months later, he developed left testicular swelling and severe induration along with a draining scrotal sinus.
  • The patient received a six-month course of antituberculous therapy.
  • [MeSH-major] BCG Vaccine / adverse effects. Carcinoma, Transitional Cell / drug therapy. Epididymitis / etiology. Orchitis / etiology. Tuberculosis, Male Genital / etiology. Urinary Bladder Neoplasms / drug therapy

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  • (PMID = 12841318.001).
  • [ISSN] 0023-9852
  • [Journal-full-title] Le Journal médical libanais. The Lebanese medical journal
  • [ISO-abbreviation] J Med Liban
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Lebanon
  • [Chemical-registry-number] 0 / BCG Vaccine
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25. Fosså SD, Aass N, Heilo A, Daugaard G, E Skakkebaek N, Stenwig AE, Nesland JM, Looijenga LH, Oosterhuis JW: Testicular carcinoma in situ in patients with extragonadal germ-cell tumours: the clinical role of pretreatment biopsy. Ann Oncol; 2003 Sep;14(9):1412-8
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  • [Title] Testicular carcinoma in situ in patients with extragonadal germ-cell tumours: the clinical role of pretreatment biopsy.
  • BACKGROUND: The aim of this study was to determine the prevalence of testicular carcinoma in situ (CIS) in patients with a malignant extragonadal germ-cell tumour (EGGCT) and the incidence of metachronous invasive testicular cancer (TC) in relation to the pretreatment demonstration of CIS.
  • PATIENTS AND METHODS: Sixty-eight patients with EGGCT (53 retroperitoneal, 15 mediastinal) had pre-chemotherapy histological assessment of one (13) or both (55) testicle(s).
  • Five patients, four of them with proven pretreatment CIS, developed a metachronous TC.
  • CIS was demonstrated in seven of 48 trans-scrotal core biopsies, in 10 of 56 trans-scrotal surgical biopsies and in five of 11 orchiectomy specimens.
  • These patients have a considerable risk of metachronous TC development in spite of chemotherapy.

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  • (PMID = 12954581.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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26. Stern RS, Bagheri S, Nichols K, PUVA Follow Up Study: The persistent risk of genital tumors among men treated with psoralen plus ultraviolet A (PUVA) for psoriasis. J Am Acad Dermatol; 2002 Jul;47(1):33-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Since that time, fewer cohort patients have used PUVA, and genital protection among PUVA users is likely to be frequent.
  • Since May 1, 1989, the incidence of invasive penile and scrotal SCCs was elevated 52.6-fold (95% confidence interval, 19.3-114.6) compared with that expected for the general white population.
  • [MeSH-major] Carcinoma, Basal Cell / etiology. Carcinoma, Squamous Cell / etiology. Ficusin / adverse effects. Genital Neoplasms, Male / etiology. Genitalia, Male / pathology. PUVA Therapy / adverse effects. Psoriasis / drug therapy. Skin Neoplasms / etiology
  • [MeSH-minor] Adult. Age Distribution. Cohort Studies. Confidence Intervals. Dose-Response Relationship, Drug. Humans. Incidence. Male. Middle Aged. Probability. Prognosis. Prospective Studies. Risk Factors

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  • (PMID = 12077578.001).
  • [ISSN] 0190-9622
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / N01 AR 44214
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] KTZ7ZCN2EX / Ficusin
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27. Harving SS, Asmussen L, Roosen JU, Hermann G: Granulomatous epididymo-orchitis, a rare complication of intravesical bacillus Calmette-Guérin therapy for urothelial cancer. Scand J Urol Nephrol; 2009;43(4):331-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granulomatous epididymo-orchitis, a rare complication of intravesical bacillus Calmette-Guérin therapy for urothelial cancer.
  • Only a few cases of tuberculous epididymo-orchitis after bacillus Calmette-Guérin (BCG) therapy have been published.
  • This report presents a case of granulomatous epididymo-orchitis after intravesical BCG therapy in a patient presenting with pain and unilateral swelling of the scrotal content.
  • This complication should always be considered when a patient presents with these symptoms after BCG therapy.
  • Isoniazid may be used as a first choice of treatment.
  • [MeSH-major] BCG Vaccine / adverse effects. BCG Vaccine / therapeutic use. Carcinoma, Transitional Cell / drug therapy. Orchitis / chemically induced. Urinary Bladder Neoplasms / drug therapy
  • [MeSH-minor] Aged. Combined Modality Therapy. Humans. Male

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  • (PMID = 19396724.001).
  • [ISSN] 1651-2065
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BCG Vaccine
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28. Tonini G, Intagliata S, Cagli B, Segreto F, Perrone G, Onetti Muda A, Santini D, Persichetti P: Recurrent scrotal hemangiomas during treatment with sunitinib. J Clin Oncol; 2010 Dec 10;28(35):e737-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent scrotal hemangiomas during treatment with sunitinib.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Genital Neoplasms, Male / chemically induced. Hemangioma / chemically induced. Indoles / adverse effects. Pyrroles / adverse effects. Scrotum / pathology. Skin Neoplasms / chemically induced
  • [MeSH-minor] Bone Density Conservation Agents / therapeutic use. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Carcinoma, Renal Cell / drug therapy. Carcinoma, Renal Cell / secondary. Diphosphonates / therapeutic use. Humans. Imidazoles / therapeutic use. Kidney Neoplasms / drug therapy. Kidney Neoplasms / pathology. Male. Middle Aged. Recurrence

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  • (PMID = 20823408.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Bone Density Conservation Agents; 0 / Diphosphonates; 0 / Imidazoles; 0 / Indoles; 0 / Pyrroles; 0 / sunitinib; 6XC1PAD3KF / zoledronic acid
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