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1. Serefhanoglu S, Goker H, Aksu S, Buyukasik Y, Sayinalp N, Haznedaroglu IC, Ozcebe OI: Spinal myeloid sarcoma in two non-leukemic patients. Intern Med; 2010;49(22):2493-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spinal myeloid sarcoma in two non-leukemic patients.
  • Myeloid sarcoma, formerly termed granulocytic sarcoma or chloroma, consists of neoplastic granulocytic precursors and myeloblasts.
  • Spinal complications of chloromas, such as cord compression secondary to epidural tumor or cauda equine syndrome have been described but are rare.
  • We herein report two cases with spinal granulocytic sarcomas in non-leukemic patients.
  • The case of a previously healthy 22-year-old man diagnosed with multiple spinal granulocytic sarcomas with no evidence of bone marrow or other hematological involvement is described.
  • And, a 43-year-old woman diagnosed cervical spinal granulocytic sarcoma with no evidence of bone marrow or other hematological involvement is described.
  • The histopathological examination was consistent with granulocytic sarcoma.
  • Granulocytic sarcoma should be considered in the differential diagnosis of an epidural mass in patients with or without acute leukemia, because early diagnosis followed by appropriate combined chemotherapy and radiation may obviate surgical intervention and eventually prevent leukemic transformation.
  • [MeSH-major] Sarcoma, Myeloid. Spinal Neoplasms

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  • (PMID = 21088356.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Amritanand R, Venkatesh K, Premkumar AJ, Sundararaj GD: Pathological dislocation of the dorsal spine following granulocytic sarcoma in a non-leukaemic patient. Eur Spine J; 2010 Jul;19 Suppl 2:S114-7
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  • [Title] Pathological dislocation of the dorsal spine following granulocytic sarcoma in a non-leukaemic patient.
  • The magnetic resonance imaging showed an enhancing soft tissue tumour.
  • The histological diagnosis of granulocytic sarcoma was confirmed by appropriate immuno-histochemical studies.
  • He declined chemotherapy and unfortunately expired 9 months later.
  • This case is presented to draw attention to the unusual presentation and to stress that granulocytic sarcoma should be kept in mind when making the differential diagnosis in patients with signs of spinal cord compression even in non-leukaemic individuals.
  • [MeSH-major] Dislocations / pathology. Sarcoma, Myeloid / pathology. Spinal Cord Compression / pathology. Spinal Neoplasms / pathology. Thoracic Vertebrae / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Fatal Outcome. Humans. Internal Fixators. Male. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology. Neurosurgical Procedures. Treatment Outcome

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  • [Cites] Neurol India. 2005 Jun;53(2):221-3 [16010065.001]
  • [Cites] Neurol Med Chir (Tokyo). 2008 Mar;48(3):131-6 [18362461.001]
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  • (PMID = 19688354.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2899635
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3. Caponetti G, Dezube BJ, Restrepo CS, Pantanowitz L: Kaposi sarcoma of the musculoskeletal system: a review of 66 patients. Cancer; 2007 Mar 15;109(6):1040-52
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  • [Title] Kaposi sarcoma of the musculoskeletal system: a review of 66 patients.
  • Kaposi sarcoma (KS) of bone and skeletal muscle is unusual.
  • They usually had bone pain with limited mobility or infrequently developed serious sequelae like spinal cord compression.
  • Computed tomography scans and magnetic resonance images were better at detecting osseous KS lesions, which frequently went undetected on plain x-ray films or bone scans.
  • Pathologic diagnosis was important to exclude similar lesions like bacillary angiomatosis.
  • Treatment options, including surgery and, in more recent patients, radiation and/or chemotherapy, had limited success.
  • [MeSH-major] Bone Neoplasms / diagnosis. Muscle Neoplasms / diagnosis. Muscle, Skeletal. Sarcoma, Kaposi / diagnosis

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  • (PMID = 17265518.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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4. Mostafavi H, Lennarson PJ, Traynelis VC: Granulocytic sarcoma of the spine. Neurosurgery; 2000 Jan;46(1):78-83; discussion 83-4
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  • [Title] Granulocytic sarcoma of the spine.
  • Spinal complications of chloromas, such as cord compression secondary to epidural tumor or cauda equina syndrome, have been described but are uncommon.
  • METHODS: We present eight new cases of spinal chloroma.
  • Treatment strategies included surgery, chemotherapy, and radiotherapy.
  • Six patients received chemotherapy, and six patients received radiotherapy at doses of 2000 to 3000 cGy in up to 30 fractions.
  • RESULTS: Patient survival ranged from 18 days to 9.5 years after diagnosis.
  • A review of the previously reported cases of granulocytic sarcoma in addition to our new cases reveals that the most effective treatment is multimodality therapy coupled with early diagnosis.
  • CONCLUSION: Increased awareness of this entity will facilitate early diagnosis and minimize potentially preventable neurological morbidity.
  • [MeSH-major] Leukemia, Myeloid / diagnosis. Spinal Cord Neoplasms / diagnosis

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  • (PMID = 10626938.001).
  • [ISSN] 0148-396X
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] UNITED STATES
  • [Number-of-references] 41
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5. Cho SH, Rhim SC, Hyun SJ, Bae CW, Khang SK: Intradural involvement of multicentric myxoid liposarcoma. J Korean Neurosurg Soc; 2010 Sep;48(3):276-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Liposarcomas are malignant tumors of the soft tissue, with myxoid liposarcoma being the second most common subtype, tending to occur in the limbs, particularly in the thighs.
  • Spinal metastasis is usual but intradural involvement is extremely rare.
  • She was histologically diagnosed with small round cell myxoid sarcoma and underwent adjuvant chemotherapy.
  • This mass consisted of extradural and intradural components causing severe compression of the spinal cord.
  • However, the patient died of multiple metastases 18 months after the first diagnosis.

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  • (PMID = 21082059.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2966733
  • [Keywords] NOTNLM ; Cervical spine / Metastasis / Multicentric / Myxoid liposarcoma / lntradural
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6. Balleari E, Panarello S, Capello E, Grosso M, Passalia C, Pitto P, Raggi F, Roccatagliata L, Cabiddu F, Ghio R: Granulocytic sarcoma: an unusual cause of spinal cord compression. Int J Clin Oncol; 2007 Jun;12(3):234-7
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  • [Title] Granulocytic sarcoma: an unusual cause of spinal cord compression.
  • A 76-year old woman presented with a large inguino-crural mass, multiple abdominal lymphoadenopathies, and neurological signs of spinal cord compression, first diagnosed as large-cell non-Hodgkin lymphoma.
  • At subsequent clinical workup, a diagnosis of granulocytic sarcoma with meningeal involvement was made.
  • Unfortunately, despite receiving intensive care, shortly after induction chemotherapy, the patient died of acute pneumonia followed by acute respiratory distress syndrome.
  • [MeSH-major] Sarcoma, Myeloid / pathology. Spinal Cord Compression / etiology. Spinal Cord Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Lymphoma, Non-Hodgkin / diagnosis. Magnetic Resonance Imaging

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  • (PMID = 17566850.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 10
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7. Kim SH, Bak KH, Kim DW, Kang TH: Primary intramedullary spinal sarcoma : a case report and review of the current literatures. J Korean Neurosurg Soc; 2010 Nov;48(5):448-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary intramedullary spinal sarcoma : a case report and review of the current literatures.
  • Primary central nervous system (CNS) sarcomas are exceedingly rare, and, to the best of our knowledge, there has not yet been a report of intramedullary sarcoma.
  • Here, we report a primary intradural intramedullary sarcoma of the spinal cord in a four-year-old boy who presented with low back pain and a radiculopathy involving both lower extremities.
  • Gross total tumor removal was performed with microelectrical pulse recording, and the patient also received adjuvant radiotherapy and chemotherapy.
  • The prognosis of primary CNS sarcoma is poor due to infiltrative nature and early CNS dissemination is common, and the treatment of choice is radical surgical resection.
  • Adjuvant therapy is also beneficial with radiotherapy and chemotherapy.

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  • (PMID = 21286485.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3030088
  • [Keywords] NOTNLM ; Central nervous system / Intramedullary / Primary / Sarcoma
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8. Landis DM, Aboulafia DM: Granulocytic sarcoma: an unusual complication of aleukemic myeloid leukemia causing spinal cord compression. A case report and literature review. Leuk Lymphoma; 2003 Oct;44(10):1753-60
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  • [Title] Granulocytic sarcoma: an unusual complication of aleukemic myeloid leukemia causing spinal cord compression. A case report and literature review.
  • Granulocytic sarcoma (chloroma) is a rare solid tumor resulting from the proliferation of myelogenous leukemia cells.
  • Chloromas usually present as soft tissue or bony masses of the head and neck in patients with acute myelogenous leukemia (AML) of the French-American-British M2 subtype.
  • Herein, we report the case of a man with a thoracic extradural chloroma whose presentation of progressive lumbar pain ultimately led to the diagnosis of M2 AML.
  • Surgical intervention prior to the onset of paraplegia and the prompt initiation of chemotherapy resulted in an excellent neurological and hematological outcome.
  • We also review the literature of previously reported cases of spinal cord-associated chloroma and focus on the clinical presentation and treatment of this disorder.
  • [MeSH-major] Leukemia, Myeloid, Acute / complications. Sarcoma, Myeloid / etiology. Spinal Cord Compression / etiology. Spinal Neoplasms / complications
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 14692530.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 58
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9. Spinazzé S, Caraceni A, Schrijvers D: Epidural spinal cord compression. Crit Rev Oncol Hematol; 2005 Dec;56(3):397-406

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidural spinal cord compression.
  • Spinal cord compression from epidural metastases (epidural spinal cord compression, ESCC) is the most common neurological complication of cancer after brain metastases.
  • Extradural compression represents 97% of spinal cord metastatic lesions.
  • The most common tumours associated with ESCC are lung and breast cancers, followed by lymphoma, myeloma, prostate cancer and sarcoma.
  • ESCC represents a medical emergency because delayed treatment can be responsible for irreversible deficits, such as paralysis and loss of sphincter control.
  • Patients with ESCC require a multidisciplinary diagnostic and therapeutic approach.
  • The median expected survival time from diagnosis usually ranges from 3 to 6 months.
  • The lack of prospective randomized trials makes the optimal treatment of ESCC controversial and the decision is to be tailored to the individual.
  • Treatment options include: bed rest, administration of corticosteroids, surgery followed by radiation therapy, radiotherapy alone and, to a limited extent, chemotherapy and hormonal therapy.
  • [MeSH-major] Epidural Neoplasms / complications. Spinal Cord Compression
  • [MeSH-minor] Female. Humans. Male. Prognosis. Treatment Outcome

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  • (PMID = 16310372.001).
  • [ISSN] 1040-8428
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 56
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10. Hsieh CT, Chiang YH, Tsai WC, Sheu LF, Liu MY: Primary spinal epidural Ewing sarcoma: a case report and review of the literature. Turk J Pediatr; 2008 May-Jun;50(3):282-6
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  • [Title] Primary spinal epidural Ewing sarcoma: a case report and review of the literature.
  • Primary extraosseous Ewing sarcoma is a rare entity, especially in the spinal epidural site.
  • Magnetic resonance imaging showed one solitary posterior extradural mass, measuring 4 x 2.2 x 2.1 cm, with severe cord compression at the level from T7 to T9.
  • The pathology confirmed a diagnosis of Ewing sarcoma after immunohistochemical staining.
  • His profound neurological deficits recovered well and no recurrence was discovered after adjuvant chemotherapy and radiotherapy.
  • [MeSH-major] Sarcoma, Ewing / pathology. Spinal Neoplasms / pathology

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  • (PMID = 18773677.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Turkey
  • [Number-of-references] 18
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11. Oliveira AM, Scheithauer BW, Salomao DR, Parisi JE, Burger PC, Nascimento AG: Primary sarcomas of the brain and spinal cord: a study of 18 cases. Am J Surg Pathol; 2002 Aug;26(8):1056-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary sarcomas of the brain and spinal cord: a study of 18 cases.
  • Median age at diagnosis of the nine female and nine male patients was 28 years (range 3-63 years).
  • Fifteen tumors arose in the cerebrum (83%), two in the cerebellum, and one in the spinal cord.
  • Histopathologically, the most common tumor types included fibrosarcoma (six), malignant fibrous histiocytoma (five), and undifferentiated sarcoma (three).
  • Immunohistochemical and ultrastructural studies supported the histologic diagnosis in 17 and six cases, respectively.
  • All patients had subtotal to gross total tumor resection; 16 also received radiotherapy and/or chemotherapy.
  • [MeSH-major] Brain Neoplasms / pathology. Sarcoma / pathology. Spinal Cord Neoplasms / pathology


12. Riffaud L, Bernard M, Lesimple T, Morandi X: Radiation-induced spinal cord glioma subsequent to treatment of Hodgkin's disease: case report and review. J Neurooncol; 2006 Jan;76(2):207-11
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  • [Title] Radiation-induced spinal cord glioma subsequent to treatment of Hodgkin's disease: case report and review.
  • Radiation-induced neoplasms of the central nervous system generally present as meningioma or sarcoma.
  • Spinal cord glioma after radiation therapy is rare and half of the cases documented occurred after treatment of Hodgkin's disease.A 39-year-old male presented with a 1-month history of gradually worsening neck ache and paraparesis.
  • The patient had been treated for stage IB Hodgkin's disease 9 years previously with combined therapy: MOPP-ABV and a 40-Gray mediastinal radiotherapy from T1 to T10.
  • Despite chemotherapy and additional radiotherapy, the patient's neurological status worsened and he died 11 months after initial presentation.
  • We suggest a strategy aimed solely at obtaining a tissue diagnosis to differentiate myelitis from tumor, and, in the event of tumor, confirming the strong likelihood of a high histopathological grade.
  • The very limited survival associated with these tumors regardless of therapy advocates palliative therapies without attempting complete resection.
  • [MeSH-major] Glioma / etiology. Hodgkin Disease / complications. Hodgkin Disease / radiotherapy. Neoplasms, Radiation-Induced / pathology. Spinal Cord Neoplasms / etiology
  • [MeSH-minor] Adult. Humans. Magnetic Resonance Imaging. Male. Spinal Cord / pathology. Tomography, X-Ray Computed

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  • (PMID = 16158216.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Ban SP, Park SH, Wang KC, Cho BK, Phi JH, Lee JY, Kim SK: Congenital paraspinal Ewing sarcoma family of tumors with an epidural extension. J Clin Neurosci; 2010 Dec;17(12):1599-601
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital paraspinal Ewing sarcoma family of tumors with an epidural extension.
  • Congenital Ewing sarcoma family of tumors (ESFT) is a rare disease, and only 12 patients have been reported.
  • Whole-spine MRI scans showed a paraspinal mass with an epidural extension from the T11 to L2 levels, causing severe spinal cord compression.
  • An initial operation was performed to confirm the pathological diagnosis.
  • The patient received adjuvant chemotherapy.
  • [MeSH-major] Bone Neoplasms / congenital. Sarcoma, Ewing / congenital. Sarcoma, Ewing / pathology. Spinal Neoplasms / congenital. Spinal Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Decompression, Surgical. Humans. Infant, Newborn. Male. Spinal Cord Compression / etiology. Spinal Cord Compression / surgery

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20817468.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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14. Verra WC, Snijders TJ, Seute T, Han KS, Nieuwenhuis HK, Rutten GJ: Myeloid sarcoma presenting as a recurrent, multifocal nerve root entrapment syndrome. J Neurooncol; 2009 Jan;91(1):59-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myeloid sarcoma presenting as a recurrent, multifocal nerve root entrapment syndrome.
  • BACKGROUND: Myeloid sarcoma is an extramedullary manifestation of haematologic malignancy, most commonly acute myeloid leukemia (AML), which can cause neurological symptoms.
  • MRI showed a mass compressing the spinal cord at level L5-S2.
  • After surgically removing the tumour pathologic examination yielded a myeloid sarcoma.
  • Combined chemotherapy and radiation therapy followed.
  • Five months later the patient developed a thoracal (Th10-Th11) radiculopathy due to a relapse of the myeloid sarcoma, followed by C8-Th1-radiculopathy caused by leptomeningeal spread.
  • CONCLUSION: This case forms the first description of recurrent, multifocal and progressive radiculopathy due to myeloid sarcoma.
  • This diagnosis should be considered in patients with radiculopathy with previous haematological malignancy and/or signs or symptoms of such disease; the absence of systemic disease activity does not rule out myeloid sarcoma.
  • [MeSH-major] Leukemia, Myeloid, Acute / complications. Nerve Compression Syndromes / etiology. Sarcoma, Myeloid / complications
  • [MeSH-minor] Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Spinal Cord / pathology. Spinal Neoplasms / complications

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  • (PMID = 18712278.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Siddiqui AA, Rehman NU: Extradural Granulocytic sarcoma causing acute paraparesis. J Coll Physicians Surg Pak; 2004 Jan;14(1):45-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extradural Granulocytic sarcoma causing acute paraparesis.
  • Radiological imaging revealed an extradural mass in the upper dorsal spine producing significant cord compression.
  • The patient showed a dramatic neurological recovery after spinal cord decompression and subsequently treated with appropriate chemotherapy and local radiotherapy.
  • [MeSH-major] Paraparesis / etiology. Sarcoma, Myeloid / diagnosis. Spinal Cord Compression / etiology. Spinal Neoplasms / diagnosis

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  • (PMID = 14764263.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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16. Widhalm G, Dietrich W, Müllauer L, Streubel B, Rabitsch W, Kotter MR, Knosp E, Roessler K: Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. J Neurosurg; 2006 Dec;105(6):916-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report.
  • The authors report the unusual case of a 35-year-old woman suffering from left leg numbness and radiculopathy due to multiple lesions in the central nervous system: one right parietal extracranial-intracranial lesion with invasion of the sensory cortex, and two intraspinal, intradural lesions compressing the spinal cord at T3-5 and S 1-4.
  • Biopsy sampling of the extracranial part of the parietal lesion led to a diagnosis of myeloid sarcoma.
  • An aggressive multimodal approach to treatment in this patient with a combination of chemotherapy, whole-body radiotherapy, and allogeneic bone marrow transplantation was started immediately.
  • To the authors' knowledge, this is the first report of a myeloid sarcoma with both intracranial and intraspinal manifestations in a patient without leukemia.
  • [MeSH-major] Brain Neoplasms / surgery. Leukemia, Myeloid, Acute / diagnosis. Neoplasms, Multiple Primary / surgery. Sarcoma, Myeloid / surgery. Skull Neoplasms / surgery. Somatosensory Cortex / pathology. Spinal Cord Compression / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Adult. Bone Marrow / pathology. Combined Modality Therapy. Decompression, Surgical. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed


17. Villa D, Knowling M: Acute saddle pulmonary embolism in Ewing sarcoma. J Pediatr Hematol Oncol; 2010 Jul;32(5):e210-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute saddle pulmonary embolism in Ewing sarcoma.
  • Two young adults had similar presentations of Ewing sarcoma, with spinal cord involvement and significant neurologic deficits.
  • Shortly after workup, stabilization, and initiation of chemotherapy, both developed acute saddle pulmonary embolism, despite prophylactic anticoagulation.
  • In both cases, prompt intravenous thrombolysis and therapeutic anticoagulation successfully managed this complication.
  • Review of the presentation, treatment options, and most current guidelines for acute saddle pulmonary embolism follow the case presentations.
  • [MeSH-major] Pulmonary Embolism / etiology. Sarcoma, Ewing / complications
  • [MeSH-minor] Adolescent. Adult. Anticoagulants / therapeutic use. Female. Humans. Male. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 20495478.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants
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18. Gunes D, Uysal KM, Cetinkaya H, Tekin HG, Yuceer N, Sarialioglu F, Olgun N: Paravertebral malignant tumors of childhood: analysis of 28 pediatric patients. Childs Nerv Syst; 2009 Jan;25(1):63-9
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  • PURPOSE: To evaluate the clinical features and treatment results of the primary paravertebral malignant tumors (PMTs) in our department.
  • Tumor diagnoses were mostly neuroblastoma (46.4%) and soft tissue sarcomas (35.7%).
  • Sixteen had cord compression (CC; 13 clinical, three radiological CC).
  • Others were managed by pediatric oncology: five with corticosteroids+/-chemotherapy (one unresponsive), one with radiotherapy (RT), and two with surgery for the clinical CC.
  • Surgery was tumor excision in nine, laminectomy in nine, laminotomy in one, and delayed surgery after chemotherapy in two cases.
  • In chemotherapy and surgery groups, there were neurologic sequela associated with the advanced disease at diagnosis in 38% and 37%, respectively.
  • The CC caused by PMTs should be initially managed with corticosteroids +/- chemotherapy to avoid the adverse late effects of RT and surgery.
  • [MeSH-major] Neuroblastoma / therapy. Spinal Cord Neoplasms / therapy. Spinal Neoplasms / therapy
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Infant. Male. Recovery of Function / physiology. Retrospective Studies. Sarcoma / therapy. Treatment Outcome

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  • (PMID = 18843494.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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19. Sevcik MA, Ghilardi JR, Peters CM, Lindsay TH, Halvorson KG, Jonas BM, Kubota K, Kuskowski MA, Boustany L, Shelton DL, Mantyh PW: Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization. Pain; 2005 May;115(1-2):128-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization.
  • As nerve growth factor (NGF) has been shown to modulate inflammatory and neuropathic pain states, we focused on a novel NGF sequestering antibody and demonstrated that two administrations of this therapy in a mouse model of bone cancer pain produces a profound reduction in both ongoing and movement-evoked bone cancer pain-related behaviors that was greater than that achieved with acute administration of 10 or 30 mg/kg of morphine.
  • This therapy also reduced several neurochemical changes associated with peripheral and central sensitization in the dorsal root ganglion and spinal cord, whereas the therapy did not influence disease progression or markers of sensory or sympathetic innervation in the skin or bone.
  • Mechanistically, the great majority of sensory fibers that innervate the bone are CGRP/TrkA expressing fibers, and if the sensitization and activation of these fibers is blocked by anti-NGF therapy there would not be another population of nociceptors, such as the non-peptidergic IB4/RET-IR nerve fibers, to take their place in signaling nociceptive events.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Femoral Neoplasms / complications. Femoral Neoplasms / drug therapy. Nerve Growth Factor / immunology. Nociceptors / drug effects. Pain / etiology. Pain / prevention & control
  • [MeSH-minor] Animals. Biomarkers / metabolism. Male. Mice. Mice, Inbred C3H. Peripheral Nerves / drug effects. Peripheral Nerves / metabolism. Sarcoma / complications. Sarcoma / diagnosis. Sarcoma / drug therapy. Spinal Cord / drug effects. Spinal Cord / metabolism. Treatment Outcome. Tumor Cells, Cultured

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  • (PMID = 15836976.001).
  • [ISSN] 0304-3959
  • [Journal-full-title] Pain
  • [ISO-abbreviation] Pain
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS048021; United States / NINDS NIH HHS / NS / NS23970
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers; 9061-61-4 / Nerve Growth Factor
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20. Bilsky MH, Schefler AC, Sandberg DI, Dunkel IJ, Rosenblum MK: Sclerosing epithelioid fibrosarcomas involving the neuraxis: report of three cases. Neurosurgery; 2000 Oct;47(4):956-9; discussion 959-60
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  • Accordingly, SEF has been regarded as a low-grade sarcoma.
  • CLINICAL PRESENTATION: Two tumors had intracranial, calvarial and extracalvarial, soft-tissue components, whereas the third tumor manifested as a paraspinal mass with extension into the T12-L1 neural foramen and invasion of the T12 nerve root.
  • In no case was there a response to adjuvant chemotherapy or radiotherapy.
  • [MeSH-major] Brain Neoplasms / diagnosis. Fibrosarcoma / diagnosis. Spinal Cord Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Sclerosis. Tomography, X-Ray Computed

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  • (PMID = 11014436.001).
  • [ISSN] 0148-396X
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
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21. Warda E, Mazurkiewicz T, Kopacz J, Gronowska S: Advances in musculoskeletal oncology: experience of the Lublin Orthopedic Clinic. Ortop Traumatol Rehabil; 2004 Oct 30;6(5):685-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Major milestones in the diagnosis and treatment of musculoskeletal tumors and tumor-like lesions are presented on the basis of the authors' 40 years of experience in the Lublin Orthopedic Clinic.
  • A prompt, adequate and complex diagnosis should be established using clinical, radiological and laboratory data.
  • The biopsy (usually trepano-biopsy) that is performed routinely can be omitted in some patients. lmmunohistochemistry tests enable adequate differential diagnosis in many cases.
  • Great progress has also been observed in treatment methods.
  • A multidisciplinary approach using neoadjuvant chemotherapy has radically improved outcomes in the treatment of ostegenic sarcoma and Ewing's sarcoma.
  • Patients with bone metastases are routinely operated for pathological fractures, large bone destruction or spinal cord compression.

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  • (PMID = 17618220.001).
  • [ISSN] 1509-3492
  • [Journal-full-title] Ortopedia, traumatologia, rehabilitacja
  • [ISO-abbreviation] Ortop Traumatol Rehabil
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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22. Passarin MG, Vattemi E, Musso AM, Romito S, Moretto G, Ghimenton C, Iuzzolino P, Doglioni C, Pedersini R: Intracranial granulocytic sarcoma after chemotherapy for pineal germinoma and testicular cancer. J Clin Oncol; 2008 Sep 20;26(27):4507-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial granulocytic sarcoma after chemotherapy for pineal germinoma and testicular cancer.
  • [MeSH-major] Brain Neoplasms / diagnosis. Meningeal Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / therapy. Pinealoma / therapy. Sarcoma, Myeloid / diagnosis. Spinal Cord Neoplasms / secondary. Testicular Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Fatal Outcome. Germinoma / diagnosis. Germinoma / therapy. Humans. Male. Neoplasm Staging. Orchiectomy. Remission Induction

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  • (PMID = 18802163.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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