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Items 1 to 21 of about 21
1. Colwell AS, D'Cunha J, Vargas SO, Parker B, Dal Cin P, Maddaus MA: Synovial sarcoma of the pleura: a clinical and pathologic study of three cases. J Thorac Cardiovasc Surg; 2002 Oct;124(4):828-32
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  • [Title] Synovial sarcoma of the pleura: a clinical and pathologic study of three cases.
  • Synovial sarcomas are rare soft tissue malignancies that most commonly affect the extremities in the vicinity of large joints.
  • A variety of pleural cavity sarcomas have been described, including liposarcoma,(3) chondrosarcoma,(4) osteosarcoma,(5) and malignant schwannoma.(6) Pleural synovial sarcoma, however, is a much rarer entity.
  • In fact, pleural synovial sarcoma was first described only 6 years ago(7) and has not yet been reported in the surgical literature.
  • Because of its rarity, pleural synovial sarcoma is often mistaken for the histologically similar malignant mesothelioma, the most common of the pleural neoplasms.
  • This is a critical distinction, because synovial sarcoma may be extremely aggressive.
  • Studies in the last 10 years have shown it to be extremely sensitive to ifosfamide-based chemotherapy, and survival of patients with synovial sarcoma has recently increased with chemotherapy, with 5-year survivals now as high as 57%.(8-10) In this report, we describe 3 cases of synovial sarcoma of the pleura.
  • [MeSH-major] Pleural Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Fatal Outcome. Female. Humans. In Situ Hybridization, Fluorescence. Male. Tomography, X-Ray Computed

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  • (PMID = 12324743.001).
  • [ISSN] 0022-5223
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Hillerdal G, Elmberger G: Malignant mediastinal tumor with bone formation--mesothelioma or sarcoma? J Thorac Oncol; 2007 Oct;2(10):983-4
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  • [Title] Malignant mediastinal tumor with bone formation--mesothelioma or sarcoma?
  • Here, we report a 57-year old man who presented with a mediastinal tumor containing scattered irregular calcifications with some scattered pleural thickening of the right pleura.
  • Biopsy showed a sarcoma with bone formation.
  • Since the tumor was pressing against the large vessels and heart, a debulking was performed, followed by Pemetrexed and Carboplatin treatment.
  • However, the tumor grew rapidly and spread to the pleura, involved the heart, and the patient succumbed.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Mesothelioma / pathology. Osteogenesis. Sarcoma / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Calcification, Physiologic. Carboplatin / administration & dosage. Glutamates / administration & dosage. Guanine / administration & dosage. Guanine / analogs & derivatives. Humans. Male. Middle Aged. Pemetrexed. Pleural Effusion, Malignant / drug therapy. Pleural Effusion, Malignant / etiology. Pleural Neoplasms / drug therapy. Pleural Neoplasms / pathology. Thoracoscopy

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  • (PMID = 17909365.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glutamates; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine; BG3F62OND5 / Carboplatin
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3. Kinderyte R, Alisauskaite L, Juodzbaliene EB, Juozaityte E: [Angiosarcoma of the breast: a case report and literature review]. Medicina (Kaunas); 2006;42(7):580-5
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  • Sarcoma of the breast is a rare tumor (makes up 0.5 to 1% of all malignant breast tumors).
  • After surgery the diagnosis of hematoma was made.
  • After review of histopathology slides the likely diagnosis of angiosarcoma of the breast was made.
  • The effect of chemotherapy and radiotherapy was only partial and short.
  • The tumor extended further to the lungs, pleura, and peritoneum.
  • A patient from the time of diagnosis survived for 8 months.
  • The mean survival of patients with angiosarcoma of the breast, described in literature, ranges from 13 to 22 months, and the treatment in this case most likely could not have an effect on survival of the patient.
  • [MeSH-minor] Adult. Breast / pathology. Diagnosis, Differential. Female. Humans. Lung Neoplasms / radiography. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Mastectomy, Simple. Prognosis. Radiography, Thoracic. Time Factors

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  • (PMID = 16861841.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Lithuania
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4. Caliandro R, Terrier P, Regnard JF, De Montpréville V, Ruffié P: [Primary biphasic synovial sarcoma of the pleura]. Rev Mal Respir; 2000 Apr;17(2):498-502
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  • [Title] [Primary biphasic synovial sarcoma of the pleura].
  • However, the atypical clinical course, the early development of lung metastases and a new reading of histologic documents led to the diagnosis of primary pleural synovial sarcoma.
  • Only a complete immuno-histochemical study confronted with the clinical course can lead to the correct diagnosis.
  • Because the efficacy of chemotherapy and/or radiotherapy is poor, surgery remains the basis of treatment, whenever possible.
  • [MeSH-major] Pleural Neoplasms / pathology. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Male. Mesothelioma / pathology. Neoplasm Recurrence, Local / pathology. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 10859770.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] FRANCE
  • [Number-of-references] 14
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5. Nishiyama N, Iwata T, Izumi N, Tsukioka T, Nagano K, Suehiro S: Aggressive repeat surgery for a recurrent synovial sarcoma in the pleura. Ann Thorac Cardiovasc Surg; 2009 Feb;15(1):46-9
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  • [Title] Aggressive repeat surgery for a recurrent synovial sarcoma in the pleura.
  • We present a case of synovial sarcoma that underwent pneumonectomy for a recurrence of the disease.
  • A 31-year-old female, who in June 2005 had undergone surgical resection of a monophasic synovial sarcoma in the left pleural cavity combined with the affected left diaphragm, was admitted to our hospital in January 2007 and underwent chemotherapy with ifosfamide, pirarubicin, and methotrexate for a recurrent synovial sarcoma in the left pleural cavity.
  • The chest computed tomography revealed multiple tumors in the left pleura, and the tumors increased rapidly to occupy the left hemithorax.
  • Pathological examination revealed dense proliferation of atypical spindle cells, the same findings as in the initial operation, and a diagnosis of synovial sarcoma was made.
  • External radiation therapy up to 60 Gray was given to the tumor remaining around the descending aorta.
  • Although optimal strategies for synovial sarcoma have yet to be established, aggressive repeat surgery could be considered in selected cases even when response to chemotherapy is insufficient and complete resection is difficult.
  • [MeSH-major] Neoplasm Recurrence, Local. Pleural Neoplasms / surgery. Pneumonectomy. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Radiotherapy, Adjuvant. Reoperation. Thoracotomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19262450.001).
  • [ISSN] 2186-1005
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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6. Iwata T, Nishiyama N, Izumi N, Tsukioka T, Suehiro S: Metastatic monophasic synovial sarcoma of the pleura. Ann Thorac Cardiovasc Surg; 2007 Aug;13(4):258-61
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  • [Title] Metastatic monophasic synovial sarcoma of the pleura.
  • Pleural metastasis of synovial sarcoma that originally developed in the soft tissue is a very rare entity.
  • An asymptomatic 25-year-old female, with a history of a resected synovial sarcoma in her left brachial muscle and pulmonary metastasectomy of the right lung, presented a small nodule in the periphery of the left lung on a routine chest-computed tomography.
  • A soft flat red tumor approximately 2 cm in diameter was shown on the pleura of the lingula, mimicking a blood clot on the pleura.
  • The mass lay in the pleura and did not seem to invade the lung parenchyma macroscopically.
  • Intraoperative frozen sectioning evidenced metastatic synovial sarcoma.
  • Many small patchy red lesions were also found on the visceral pleura of the lung and parietal pleura of the diaphragm.
  • We diagnosed unresectable pleural metastases of synovial sarcoma and finished the operation after sampling another pulmonary pleural lesion.
  • The patient then underwent ifomide-based chemotherapy and survived for 3 years after her initial surgery.
  • Postoperative histopathological examination revealed a solid and bundle-like proliferation of a short spindle cell tumor with a monophasic pattern, which was diagnosed as a metastatic pleural synovial sarcoma.
  • [MeSH-major] Muscle Neoplasms / pathology. Pleural Neoplasms / secondary. Sarcoma, Synovial / secondary

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  • (PMID = 17717503.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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7. Zhao J, Wang MZ, Li LY, Zhang L, Zhong W: [Clinical features of pulmonary malignancies in patients younger than 30 years of age]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2010 Apr;32(2):174-8
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  • The mean time from the onset of disease to confirmed diagnosis was (5.98+/-8.95) months.
  • The proportion of tumors in limited stage was 72.73% in 11 patients with small cell lung cancer, and most patients (54.55) were not sensitive to conventional chemotherapy.
  • In 6 patients with carcinoid, 4 patients were central and the other 2 patients were peripheral, and all of them presented as Cushing syndrome; CgA, AE1/AE3, Syn, and NSE were positive in immunohistochemical staining; and surgical operation was the main treatment for them.
  • In 6 patients with carcinomas of salivary gland type, all cases were central; no lymph nodes metastasis was found in the postoperative specimen; and surgical operation was also the main treatment for these patients.
  • In 3 patients with primitive neuroectodermal tumors, the tumors were highly malignant and invasive, and the development of primitive neuroectodermal tumors was closely related with pleura.
  • Multiple nodules in bilateral lungs were presented in 2 patients with anaplastic large cell lymphomas, in which CD30 was positive in tumor cells; chemotherapy was the main therapy for these two patients.
  • In one patient with synovial sarcoma, the tumor was giant and highly malignant and invasive; it was divided into many cavities filled with bloody fluid and white cheese-like substances; immunohistochemical analysis showed positive vimentin and AE1/AE3.
  • The treatment strategy should be based on the specific conditions of each patient.

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  • (PMID = 20450548.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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8. Sales Badia JG, Galbis Caravajal JM, Viñals Larruga B, Luna Arnal D, Cordero Rodríguez P, Cuevas Sanz JM: [Pneumonectomy with extracorporeal circulation to treat pulmonary metastasis]. Arch Bronconeumol; 2007 Mar;43(3):180-2
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  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Arm. Chemotherapy, Adjuvant. Combined Modality Therapy. Femoral Neoplasms / drug therapy. Femoral Neoplasms / pathology. Femoral Neoplasms / surgery. Heart Atria / pathology. Heart Atria / surgery. Humans. Male. Pericardiectomy / methods. Pericardium / pathology. Pericardium / surgery. Pleura / pathology. Pleura / surgery. Pulmonary Veins / pathology. Pulmonary Veins / surgery. Sarcoma / pathology. Sarcoma / radiotherapy. Sarcoma / surgery. Thoracic Wall / pathology. Thoracic Wall / surgery. Tomography, X-Ray Computed

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  • (PMID = 17386197.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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9. Veronesi G, Spaggiari L, Mazzarol G, De Pas M, Leo F, Solli P, Pastorino U: Huge malignant localized fibrous tumor of the pleura. J Cardiovasc Surg (Torino); 2000 Oct;41(5):781-4
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  • [Title] Huge malignant localized fibrous tumor of the pleura.
  • The malignant variant of the pleura is exceptional and differential diagnosis with the more frequent benign type or with other neoplasms such as soft tissue sarcoma and mesothelioma is rarely possible in a preoperative setting.
  • The best treatment of this disease is radical surgical resection.
  • No definitive data exist about the role of chemotherapy.
  • We report a case of a giant right intrathoracic mass whose preoperative diagnosis, from an open biopsy, was consistent with sarcoma and, in a second review, with fibrous tumor of the pleura without any indication about malignancy.
  • In consideration of the apparent local radicality we did not perform any adjuvant treatment.
  • Six months after the operation a wide local recurrence was evident and a systemic treatment with Ifosfamide and Adriamicina is still in progress.
  • Preoperative diagnosis of malignancy has an important role as a therapeutic strategy in management of fibrous tumours of the pleura.
  • When there is suspicion of a malignant form neoadjuvant chemotherapy can represent a further tool to control poorly differentiated and large tumors, and a wide surgical resection of the lesion must be performed.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Doxorubicin / therapeutic use. Humans. Ifosfamide / therapeutic use. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Pneumonectomy

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  • (PMID = 11149649.001).
  • [ISSN] 0021-9509
  • [Journal-full-title] The Journal of cardiovascular surgery
  • [ISO-abbreviation] J Cardiovasc Surg (Torino)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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10. Ayadi L, Chaabouni S, Chabchoub I, Ayadi A, Kallel R, Fakhfakh I, Hachicha M, Boudawara T: [Primary rhabdomyosarcoma of the pleura presenting as recurrent pneumothorax]. Rev Mal Respir; 2009 Mar;26(3):333-7
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  • [Title] [Primary rhabdomyosarcoma of the pleura presenting as recurrent pneumothorax].
  • INTRODUCTION: Rhabdomyosarcoma is the most common soft tissue sarcoma in the first two decades of life.
  • It rarely arises in the thorax including the pleura.
  • Our aim is to discuss the clinical presentation, treatment and prognosis of this uncommon location of rhabdomyosarcoma.
  • CASE REPORT: We report a case of primary embryonal rhabdomyosarcoma of the pleura in a boy of 21 months.
  • A computed tomography scan showed only pleural detachment with no evidence of any pleural disease.
  • Despite chemotherapy, the tumour quickly increased in size and the infant died from acute respiratory failure.
  • CONCLUSION: Thoracic rhabdomyosarcoma is rare and remains clinically silent for a long time.
  • [MeSH-major] Pleural Neoplasms / diagnosis. Pneumothorax / etiology. Rhabdomyosarcoma / diagnosis

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  • (PMID = 19367209.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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11. Deslée G, Guillou PJ, Baehrel B, Lebargy F: Malignant mesenchymoma of the pleura. Interact Cardiovasc Thorac Surg; 2003 Sep;2(3):376-8

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  • [Title] Malignant mesenchymoma of the pleura.
  • Malignant mesenchymomas are rare soft tissue tumors of mesenchymal origin.
  • The treatment associated surgical resection, chemotherapy and radiotherapy.
  • Sixteen months after the diagnosis a metastatic retroperitoneal sarcoma with osteosarcomatous differentiation appeared without any sign of thoracic recurrence.

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  • (PMID = 17670075.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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12. Mirzoyan M, Muslimani A, Setrakian S, Swedeh M, Daw HA: Primary pleuropulmonary synovial sarcoma. Clin Lung Cancer; 2008 Sep;9(5):257-61
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  • [Title] Primary pleuropulmonary synovial sarcoma.
  • Pleuropulmonary synovial sarcoma (PPSS) is increasingly recognized as a subtype of sarcoma because of the recent identification of a distinctive chromosomal translocation specific to synovial sarcoma.
  • Soft-tissue synovial sarcoma is far more common than PPSS and typically develops in para-articular locations of the extremities, affects young and middle-aged adults, with no difference in distribution between the sexes, and has well-documented radiologic manifestations.
  • Pleuropulmonary synovial sarcoma can arise in the chest wall, heart, mediastinum, pleura, or lung, and it shares patient demographics and several imaging features with its soft-tissue counterpart.
  • On chest radiographs, PPSS typically appears as a sharply marginated mass with uniform opacity, based in the pleura or in the lung, and often accompanied by an ipsilateral pleural effusion.
  • Magnetic resonance imaging provides superior demonstration of nodular soft tissue and multilocular fluid-filled internal components of PPSS, in addition to peripheral rim enhancement after the intravenous administration of a gadoliniumbased contrast material such as gadopentetate dimeglumine.
  • Current treatment consists of surgical resection followed by chemotherapy, radiation therapy, or both.
  • [MeSH-major] Lung Neoplasms / pathology. Pleural Neoplasms / pathology. Sarcoma, Synovial / pathology

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  • (PMID = 18824448.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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13. Frazier AA, Franks TJ, Pugatch RD, Galvin JR: From the archives of the AFIP: Pleuropulmonary synovial sarcoma. Radiographics; 2006 May-Jun;26(3):923-40
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  • [Title] From the archives of the AFIP: Pleuropulmonary synovial sarcoma.
  • Pleuropulmonary synovial sarcoma (PPSS) is increasingly recognized as a subtype of sarcoma because of the recent identification of a distinctive chromosomal translocation specific to synovial sarcoma.
  • Soft-tissue synovial sarcoma is far more common than PPSS and typically develops in para-articular locations of the extremities; affects young and middle-aged adults, with no difference in distribution between the sexes; and has well-documented radiologic manifestations.
  • PPSS may arise in the chest wall, heart, mediastinum, pleura, or lung, and it shares patient demographics and several imaging features with its soft-tissue counterpart.
  • On chest radiographs, PPSS typically appears as a sharply marginated mass with uniform opacity, based either in the pleura or in the lung, and often accompanied by an ipsilateral pleural effusion.
  • Magnetic resonance imaging provides superior demonstration of nodular soft tissue and multilocular fluid-filled internal components of PPSS, in addition to peripheral rim enhancement after the intravenous administration of a gadolinium-based contrast material such as gadopentetate dimeglumine.
  • Current treatment consists of surgical resection followed by chemotherapy, radiation therapy, or both.
  • [MeSH-major] Image Enhancement / methods. Lung Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Pleural Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis

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  • (PMID = 16702463.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 47
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14. Nasilowska-Adamska B, Majewski M, Seferynska I, Szczepinski A, Tomaszewska A, Prochorec-Sobieszek M, Guz K, Torbicki A, Warzocha K, Marianska B: Predictive value of RT-PCR PML-RARA transcript monitoring for extramedullary relapse of acute promyelocytic leukemia in the pleura, heart and pericardium after allogeneic SCT. Ann Transplant; 2007;12(3):33-8
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  • [Title] Predictive value of RT-PCR PML-RARA transcript monitoring for extramedullary relapse of acute promyelocytic leukemia in the pleura, heart and pericardium after allogeneic SCT.
  • BACKGROUND: We report a patient with acute promyelocytic leukemia (APL) relapse in extremely rare sites--the pleura, heart and pericardium without evidence of bone marrow infiltration and with molecular evidence of disease after allogeneic stem cell transplantation (alloSCT).
  • After transplant, this patient remained in complete hematological and cytogenetic remission but nested RT-PCR assays with detection thresholds of 10(-3)/10(-4) were positive for PML-RARA rearranged gene even chimerism tests showed 100% of donor profile.
  • Twenty one months after transplant, the leukemic relapse in the pleura, heart and pericardium was diagnosed.
  • At that time, PML-RARA transcript detected in RT-PCR assay (10(-2)) was positive for the first time after transplant.
  • During salvage chemotherapy he died because of cardiogenic shock.
  • CONCLUSIONS: We conclude that detection of PML-RARA after alloSCT should be indication insightful diagnosis of medullary or extramedullary (EM) relapse.
  • [MeSH-major] Heart Neoplasms / diagnosis. Leukemia, Promyelocytic, Acute / genetics. Oncogene Proteins, Fusion / genetics. Pleural Neoplasms / diagnosis. Sarcoma, Myeloid / diagnosis. Stem Cell Transplantation

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  • (PMID = 18290568.001).
  • [ISSN] 1425-9524
  • [Journal-full-title] Annals of transplantation
  • [ISO-abbreviation] Ann. Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
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15. Casali PG, Stacchiotti S, Palassini E, Marrari A, Negri T, Morosi C, Messina A, Pastorino U, Gronchi A, Pilotti S: Evaluation of the antitumor activity of sunitinib malate (SM) in solitary fibrous tumor (SFT). J Clin Oncol; 2009 May 20;27(15_suppl):10571

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  • : 10571 Background: SFT is a rare soft tissue tumor, with an unpredictable metastatic potential.
  • When medical therapy is needed, cytotoxic chemotherapy is poorly active in this sarcoma subtype, but the activity of bevacizumab + temozolomide was recently reported.
  • METHODS: From April 2008, 5 patients with progressive metastatic SFT resistant to conventional chemotherapy (male/female: 3/2 - mean-age: 58 years - PS: 0-3 - site: peritoneum 3, pleura 1, bladder 1) have been treated with continuous-dosing SM 37.5 mg/day, on an individual use basis.
  • All patients were evaluated for response at least once, while 2 more patients are now starting therapy.
  • The other patient stopped therapy for progression after 3 weeks and died 2 weeks later.
  • One responsive patient stopped therapy after 3 weeks for side effects and depression.
  • The remaining 3 responsive patients are currently on treatment, although one had a focal progression after 9 months.
  • This might help address an unmet clinical need in a rare sarcoma subtype.

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  • (PMID = 27963778.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Hung JJ, Chou TY, Sun CH, Liu JS, Hsu WH: Primary synovial sarcoma of the posterior chest wall. Ann Thorac Surg; 2008 Jun;85(6):2120-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary synovial sarcoma of the posterior chest wall.
  • Synovial sarcoma is a malignant soft-tissue tumor that most commonly occurs in the extremities of young adults.
  • Only several cases of synovial sarcomas of the chest wall and pleura had been reported.
  • We present a 24-year-old man who had right back pain, chest pain, dyspnea, and intermittent fever from a huge primary synovial sarcoma of the right posterior chest wall.
  • Multimodality therapies, including surgical resection, and chemotherapy and radiation therapy were applied, but the tumor progressed rapidly and the patient died 6 months after diagnosis.
  • Prompt diagnosis and aggressive surgical resection is mandatory for primary synovial sarcoma of the chest wall because of its aggressive behavior.
  • [MeSH-major] Sarcoma, Synovial / surgery. Thoracic Neoplasms / surgery. Thoracic Wall / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Disease Progression. Humans. Male. Palliative Care. Tomography, X-Ray Computed

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  • (PMID = 18498838.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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17. Anderson TM, Dougherty TJ, Tan D, Sumlin A, Schlossin JM, Kanter PM: Photodynamic therapy for sarcoma pulmonary metastases: a preclinical toxicity study. Anticancer Res; 2003 Sep-Oct;23(5A):3713-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photodynamic therapy for sarcoma pulmonary metastases: a preclinical toxicity study.
  • However, using single beam pleural surface treatment all light doses for HPPH and Photofrin (5-40 J/cm2) were tolerated with depths of treatment effect up to 10 mm with HPPH.
  • PDT holds promise as an adjuvant treatment for sarcoma pulmonary metastases.
  • [MeSH-major] Chlorophyll / analogs & derivatives. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Photochemotherapy / adverse effects. Sarcoma, Experimental / drug therapy. Sarcoma, Experimental / secondary
  • [MeSH-minor] Animals. Dihematoporphyrin Ether / adverse effects. Dihematoporphyrin Ether / therapeutic use. Dogs. Hemorrhage / chemically induced. Lung Diseases / chemically induced. Photosensitizing Agents / adverse effects. Photosensitizing Agents / therapeutic use. Pleura / pathology

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  • (PMID = 14666668.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 1406-65-1 / Chlorophyll; 149402-51-7 / 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a; 97067-70-4 / Dihematoporphyrin Ether
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18. Gebhard S, Coindre JM, Michels JJ, Terrier P, Bertrand G, Trassard M, Taylor S, Château MC, Marquès B, Picot V, Guillou L: Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol; 2002 May;26(5):601-16
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  • [Title] Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group.
  • Treatment procedures in 51 patients consisted of simple tumorectomy (16) and wide excision (33).
  • Five and 31 patients received neoadjuvant and adjuvant chemotherapy and/or radiation therapy, respectively.
  • Follow-up (48 patients, range 7-276 months; median 38 months) showed a 45% local recurrence rate and a 42.5% metastasis rate, metastases occurring mostly in lungs and pleura.
  • Seventeen patients (35%) died of disease, of whom none was metastatic at diagnosis.
  • [MeSH-major] Liposarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Proteins / analysis. Survival Rate. Treatment Outcome

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  • (PMID = 11979090.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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19. Dursunoğlu N, Kiter G, Oztürk E, Tunç P, Colakoğlu N, Değirmencioğlu S, Yaren A: An old woman with weight loss and chest pain. Tuberk Toraks; 2010;58(1):85-8
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  • The most important entity in the differential diagnosis is metastatic synovial sarcoma.
  • A chest computerised tomography showed enlarged mediastinal lymph nodes were observed, as well as a left-sided pleural effusion.
  • Left sided thoracoscopy was performed under local anesthesia, total collapse of left lung and multiple pleural nodules were observed on the visceral pleura multiple biopsies were obtained from those nodules.
  • Pathologic examinations revealed "synovial sarcoma".
  • As skeleton single photon emission tomography was unremarkable, primary pleuropulmonary synovial sarcoma was decided as diagnosis and chemotherapy was planned for the patient.
  • Primary pleuropulmonary synovial sarcoma is a rare neoplasm of lung and pleura but it is rare entity.
  • [MeSH-major] Chest Pain / diagnosis. Lung Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis. Weight Loss
  • [MeSH-minor] Aged. Biopsy. Female. Humans. Pleural Effusion / diagnosis. Pleural Effusion / etiology. Thoracoscopy

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  • (PMID = 20517734.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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20. Antoine M: [Contribution of immunohistochemistry to the management of lung cancer: from morphology to diagnosis and treatment]. Rev Pneumol Clin; 2007 Jun;63(3):183-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Contribution of immunohistochemistry to the management of lung cancer: from morphology to diagnosis and treatment].
  • [Transliterated title] Qu'apporte l'immunohistochimie à la prise en charge du cancer bronchique? De la morphologie au diagnostic et au traitement.
  • By demonstrating the presence of carcinomatous cells within the neighboring structures (pleura) or lymph nodes, IHC contributes to lung cancer staging, particularly when there are few of these elements morphologically difficult to distinguish.
  • Finally, IHC contributes to prognosis (proliferation markers, differentiation markers) or prediction of therapeutic response (chemotherapy or targeted therapies).
  • Other morphological techniques such as hybridization in situ or molecular biology techniques will further complete the histological diagnosis in the future.
  • [MeSH-minor] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Carcinoma, Large Cell / pathology. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / pathology. Chorionic Gonadotropin, beta Subunit, Human / analysis. Forecasting. Humans. Lymph Nodes / pathology. Lymphoma / pathology. Mediastinal Neoplasms / pathology. Melanoma / pathology. Neoplasm Staging. Neuroendocrine Tumors / pathology. Pleural Neoplasms / pathology. Prognosis. Sarcoma / pathology. alpha-Fetoproteins / analysis

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  • (PMID = 17675942.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / alpha-Fetoproteins
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21. Raney RB, Anderson JR, Andrassy RJ, Crist WM, Donaldson SS, Maurer HM, Intergroup Rhabdomyosarcoma Study Group: Soft-tissue sarcomas of the diaphragm: a report from the Intergroup Rhabdomyosarcoma Study Group from 1972 to 1997. J Pediatr Hematol Oncol; 2000 Nov-Dec;22(6):510-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Soft-tissue sarcomas of the diaphragm: a report from the Intergroup Rhabdomyosarcoma Study Group from 1972 to 1997.
  • PATIENTS AND METHODS: We reviewed the records of 15 patients with sarcoma of the diaphragm who were entered on IRS Group protocols between 1972 and 1997.
  • Patient ages at diagnosis ranged from 0.5 to 20 years (median, 13 yrs), and 10 were girls.
  • RESULTS: Localized, gross residual disease after initial surgery was present in 10 patients, and five had metastases at diagnosis (pleura, 3; pericardium, 1; lungs and bones, 1).
  • Tumor subtypes were alveolar rhabdomyosarcoma (RMS) in five cases, embryonal RMS in three, undifferentiated sarcoma in three, extraosseous Ewing sarcoma in three, and unclassified sarcoma in one.
  • Treatment consisted of radiation therapy to the primary tumor and metastases when feasible, and combination chemotherapy with vincristine, actinomycin D, and cyclophosphamide with or without doxorubicin, ifosfamide, cisplatin, and etoposide.
  • Five patients (33%) are continuously failure-free and alive at a median of 8.8 years from diagnosis (range, 1.1-15 yrs).
  • However, the other 10 patients experienced relapse at 0.3 to 2 years from start of therapy (median, 1 yr).
  • Death after relapse occurred at 0.39 to 2.6 years (median, 1.6 yrs) from diagnosis.
  • CONCLUSIONS: Sarcomas of the diaphragm are generally deemed unresectable at diagnosis and/or are metastatic.
  • Treatment with more effective primary chemotherapy to shrink the tumor, followed-up by surgical resection and radiation therapy, should improve the prognosis for patients with sarcomas arising in the diaphragm, especially for the majority who have localized tumors.
  • [MeSH-major] Muscle Neoplasms / therapy. Rhabdomyosarcoma / therapy
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Diaphragm. Female. Humans. Infant. Male. Radiotherapy Dosage. Recurrence. Retrospective Studies. Survival Rate

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  • (PMID = 11132218.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-24507; United States / NCI NIH HHS / CA / CA-72989
  • [Publication-type] Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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