[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 29 of about 29
1. Zidan J, Robenstein W, Abzah A, Taman S: Treatment of Kaposi's sarcoma with vinblastine in patients with disseminated dermal disease. Isr Med Assoc J; 2001 Apr;3(4):251-3
Hazardous Substances Data Bank. VINBLASTINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of Kaposi's sarcoma with vinblastine in patients with disseminated dermal disease.
  • BACKGROUND: Classic Kaposi's sarcoma is a rare tumor with an indolent behavior.
  • Local therapy is not applicable in disseminated cutaneous disease.
  • Patients with advanced disease are usually treated with systemic chemotherapy.
  • OBJECTIVES: To assess the effectiveness and toxicity of single-agent vinblastine in the treatment of disseminated and recurrent Kaposi's sarcoma.
  • METHODS: Ten patients with wide cutaneous spread of classic Kaposi's sarcoma were treated with single-agent vinblastine, 6 mg/m2 intravenously once every 2 weeks.
  • CONCLUSIONS: Vinblastine is very effective in the treatment of extensive classic 'Kaposi's sarcoma, and results in a high response rate, long survival and disease-free survival with tolerable toxicity.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Sarcoma, Kaposi / drug therapy. Vinblastine / therapeutic use
  • [MeSH-minor] Aged. Disease-Free Survival. Drug Administration Schedule. Female. Humans. Israel. Jews. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11344835.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 5V9KLZ54CY / Vinblastine
  •  go-up   go-down


2. Lim ST, Tupule A, Espina BM, Levine AM: Weekly docetaxel is safe and effective in the treatment of advanced-stage acquired immunodeficiency syndrome-related Kaposi sarcoma. Cancer; 2005 Jan 15;103(2):417-21
Hazardous Substances Data Bank. DOCETAXEL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Weekly docetaxel is safe and effective in the treatment of advanced-stage acquired immunodeficiency syndrome-related Kaposi sarcoma.
  • BACKGROUND: Intravenous paclitaxel, 100 mg/m(2), given over 3 hours every 2 weeks is associated with a response rate of 59% in patients with recurrent or refractory acquired immunodeficiency syndrome (AIDS)-related Kaposi sarcoma (KS).
  • Moreover, no effective therapies have been defined for use after treatment failure with this agent.
  • Thereafter, if the patient experienced stable disease or better response, treatment doses were given every other week until complete disease remission, disease progression, or unacceptable toxicity occurred.
  • Ten patients (83%) had previous systemic chemotherapy, including 4 who received previous paclitaxel.
  • Treatment was well tolerated, with no Grade 4 toxicity of any type.
  • The median time to disease progression was 26 months (range, 5-53 months).
  • CONCLUSIONS: Weekly docetaxel is safe, with reasonable antitumor activity in patients with advanced-stage, recurrent, or refractory AIDS-related KS.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Sarcoma, Kaposi / drug therapy. Sarcoma, Kaposi / pathology. Skin Neoplasms / pathology. Taxoids / administration & dosage
  • [MeSH-minor] Adult. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Infusions, Intravenous. Male. Middle Aged. Neoplasm Staging. Risk Assessment. Survival Analysis. Treatment Outcome


3. Yildiz F, Genc M, Akyurek S, Cengiz M, Ozyar E, Selek U, Atahan IL: Radiotherapy in the management of Kaposi's sarcoma: comparison of 8 Gy versus 6 Gy. J Natl Med Assoc; 2006 Jul;98(7):1136-9
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiotherapy in the management of Kaposi's sarcoma: comparison of 8 Gy versus 6 Gy.
  • OBJECTIVE: To evaluate prospectively the efficacy of a single fraction of high-dose radiotherapy in patients with Kaposi's sarcoma.
  • PATIENTS: Between 1994 and 2004, 47 patients with Kaposi's sarcoma were treated at Hacettepe University, Department of Radiation Oncology.
  • Thirteen (28%) patients received chemotherapy before radiotherapy and were referred due to recurrent or progressive disease or intolerance to chemotherapy.
  • Radiotherapy consisted of a single fraction of 8 Gy in the first four years and 6 Gy thereafter.
  • Of 203 fields treated, 51 and 152 fields were treated with 8 Gy and 6 Gy, respectively.
  • Overall response rates (RR) at 12 months for 8- and 6 Gy were 93% and 86%, which were not statistically different.
  • However, the difference between complete RRs at 12 months (93% and 60% for 8 Gy and 6 Gy respectively) was significant (p<0.0001).
  • CONCLUSION: Radiotherapy is an effective mode of treatment for Kaposi's sarcoma, and a single dose of 8 Gy is more effective in terms of complete RR compared to 6 Gy, though overall response and progression-free survival rates were similar.
  • [MeSH-major] Hodgkin Disease / immunology. Sarcoma, Kaposi / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Hospitals, Teaching. Humans. Immunocompromised Host. Male. Middle Aged. Prospective Studies. Radiotherapy Dosage. Treatment Outcome. Turkey

  • MedlinePlus Health Information. consumer health - Hodgkin Disease.
  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Int J Cancer. 2005 Feb 10;113(4):632-9 [15472910.001]
  • [Cites] Int J Oncol. 1999 Jun;14(6):1097-102 [10339664.001]
  • [Cites] Anticancer Res. 1999 Sep-Oct;19(5C):4539-44 [10650807.001]
  • [Cites] N Engl J Med. 2000 Apr 6;342(14):1027-38 [10749966.001]
  • [Cites] Dermatology. 2001;202(2):119-22 [11306832.001]
  • [Cites] Cancer. 1978 May;41(5):1733-8 [417796.001]
  • [Cites] Cancer. 1980 Feb 15;45(4):684-7 [6766794.001]
  • [Cites] Cancer. 1981 Feb 15;47(4):640-4 [6784910.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1986 Nov;12(11):1931-5 [3771313.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1986 Nov;12(11):2029-32 [3095276.001]
  • [Cites] Semin Oncol. 1987 Jun;14(2 Suppl 3):19-22 [2440108.001]
  • [Cites] Dermatologica. 1990;180(1):13-7 [2307273.001]
  • [Cites] J Am Acad Dermatol. 1990 Jun;22(6 Pt 2):1237-50 [2193952.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1990 Sep;19(3):569-75 [2211205.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1991 Mar;20(3):419-22 [1995526.001]
  • [Cites] Epidemiol Rev. 1991;13:178-99 [1765111.001]
  • [Cites] Am J Clin Oncol. 1992 Jun;15(3):200-6 [1590271.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1993 Dec 1;27(5):1057-61 [8262827.001]
  • [Cites] Dermatology. 1994;188(3):182-7 [8186506.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1994 Dec 1;30(5):1207-11 [7525519.001]
  • [Cites] Int J Dermatol. 1994 Nov;33(11):755-62 [7822076.001]
  • [Cites] J Am Acad Dermatol. 1995 Jun;32(6):1000-3 [7538517.001]
  • [Cites] Dermatology. 1997;195(2):142-4 [9310721.001]
  • [Cites] Radiother Oncol. 1998 Jan;46(1):23-8 [9488123.001]
  • [Cites] J Virol. 1999 Feb;73(2):1438-46 [9882349.001]
  • [Cites] Radiother Oncol. 2005 Jul;76(1):59-62 [16019094.001]
  • (PMID = 16895284.001).
  • [ISSN] 1943-4693
  • [Journal-full-title] Journal of the National Medical Association
  • [ISO-abbreviation] J Natl Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2569458
  •  go-up   go-down


Advertisement
4. Gilaberte M, Gallardo F, Bellosillo B, Saballs P, Barranco C, Serrano S, Pujol RM: Recurrent and self-healing cutaneous monoclonal plasmablastic infiltrates in a patient with AIDS and Kaposi sarcoma. Br J Dermatol; 2005 Oct;153(4):828-32
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent and self-healing cutaneous monoclonal plasmablastic infiltrates in a patient with AIDS and Kaposi sarcoma.
  • We report a 44-year-old man with AIDS and Kaposi sarcoma (KS) previously treated with doxorubicin who, following treatment with highly active antiretroviral therapy, developed an erythematous infiltrated nodule on the right arm.
  • Two years later an infiltrated plaque developed on the abdominal wall.
  • PBL may be seen in patients with transplants or receiving chemotherapy, but is usually observed in patients with advanced AIDS.
  • The observation of recurrent self-healing EBV- and HHV-8-associated cutaneous monoclonal plasmablastic infiltrates, in a patient with AIDS and KS, expands the clinical spectrum of AIDS-associated plasmablastic lymphoproliferative disorders.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Epstein-Barr Virus Infections / complications. Herpesvirus 8, Human. Lymphoma, AIDS-Related / virology. Sarcoma, Kaposi / complications

  • Genetic Alliance. consumer health - AIDS-HIV.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16181470.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


5. Ramdial PK, Sing Y, Hadley GP, Chotey NA, Mahlakwane MS, Singh B: Paediatric intussusception caused by acquired immunodeficiency syndrome-associated Kaposi sarcoma. Pediatr Surg Int; 2010 Aug;26(8):783-7
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paediatric intussusception caused by acquired immunodeficiency syndrome-associated Kaposi sarcoma.
  • PURPOSE: To document the clinicopathological features of paediatric intussusception caused by acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma (KS).
  • Three patients each had ileal and ileocolic intussusceptions; two had recurrent intussusception.
  • One patient, who received post-surgical chemotherapy and HAART, is currently in remission.
  • Resection of the infarcted segment may relieve the presenting obstruction, but recurrent intussusception may occur because every elevated KS is a potential lead point.
  • AIDS-KS-I is rare but fatal in children, unless timely surgical intervention, optimal histopathological diagnosis, and appropriate medical management, including HAART and chemotherapy, are facilitated.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Intussusception / etiology. Sarcoma, Kaposi / complications
  • [MeSH-minor] Antiretroviral Therapy, Highly Active. Child, Preschool. Humans. Male. Retrospective Studies

  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Gastroenterol. 1995 Sep;21(2):158-62 [8583084.001]
  • [Cites] ANZ J Surg. 2007 Sep;77(9):778-81 [17685958.001]
  • [Cites] S Afr Med J. 1985 Sep 14;68(6):405-6 [4035512.001]
  • [Cites] Adv Anat Pathol. 2002 Nov;9(6):360-70 [12409645.001]
  • [Cites] Afr J Paediatr Surg. 2008 Jan-Jun;5(1):24-8 [19858659.001]
  • [Cites] MMWR Recomm Rep. 2008 Dec 5;57(RR-10):1-12 [19052530.001]
  • [Cites] Pediatr Pathol Lab Med. 1997 Mar-Apr;17(2):171-208 [9086527.001]
  • [Cites] Ital J Gastroenterol. 1994 Sep;26(7):329-33 [7812024.001]
  • [Cites] J R Coll Surg Edinb. 1987 Dec;32(6):339-41 [3448187.001]
  • [Cites] J Pediatr Surg. 1996 Dec;31(12):1607-10 [8986970.001]
  • [Cites] J Med Case Rep. 2009 Feb 11;3:61 [19210783.001]
  • [Cites] Am J Gastroenterol. 1988 Nov;83(11):1304-5 [3189268.001]
  • [Cites] Arch Dis Child. 1995 Aug;73(2):100-4; discussion 104-5 [7574850.001]
  • [Cites] Am J Gastroenterol. 1986 Nov;81(11):1073-5 [3776957.001]
  • [Cites] Hematol Oncol Clin North Am. 1996 Oct;10(5):1189-201 [8880205.001]
  • [Cites] J Pediatr Surg. 2009 Feb;44(2):373-6 [19231537.001]
  • [Cites] AIDS Clin Care. 1997 May;9(5):40, 44 [11364298.001]
  • [Cites] J Am Acad Dermatol. 1993 Mar;28(3):449-53 [8445061.001]
  • [Cites] AJR Am J Roentgenol. 1994 Feb;162(2):387-93 [8310932.001]
  • [Cites] Afr J Paediatr Surg. 2009 Jul-Dec;6(2):131 [19661651.001]
  • [Cites] J Formos Med Assoc. 2002 Aug;101(8):585-7 [12440091.001]
  • [Cites] J Pediatr Surg. 2006 Apr;41(4):817-20 [16567200.001]
  • (PMID = 20535484.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


6. Hsu CH, Chen MY, Cheng AL: Treatment of recurrent Kaposi's sarcoma of an AIDS patient with weekly paclitaxel. Anticancer Res; 2000 Mar-Apr;20(2B):1159-61
Hazardous Substances Data Bank. RANITIDINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of recurrent Kaposi's sarcoma of an AIDS patient with weekly paclitaxel.
  • Paclitaxel was recently recognized as an active chemotherapeutic agent for acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma (KS).
  • Herein, we reported an AIDS-associated KS patient whose disease progressed on the first-line chemotherapy with doxorubicin and bleomycin, but later responded well to weekly 1-hour infusion of 70 mg/m2 paclitaxel.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Antineoplastic Agents, Phytogenic / therapeutic use. Paclitaxel / therapeutic use. Sarcoma, Kaposi / drug therapy
  • [MeSH-minor] Adult. Dexamethasone / therapeutic use. Diphenhydramine / therapeutic use. Drug Administration Schedule. Humans. Infusions, Intravenous. Male. Ranitidine / therapeutic use

  • Genetic Alliance. consumer health - AIDS-HIV.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • HIV InSite. treatment guidelines - Human Herpesvirus-8 .
  • Hazardous Substances Data Bank. TAXOL .
  • Hazardous Substances Data Bank. DEXAMETHASONE .
  • Hazardous Substances Data Bank. DIPHENHYDRAMINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 10810414.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] GREECE
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 7S5I7G3JQL / Dexamethasone; 884KT10YB7 / Ranitidine; 8GTS82S83M / Diphenhydramine; P88XT4IS4D / Paclitaxel
  •  go-up   go-down


7. Mohrbacher AF, Gregory SA, Gabriel DA, Rusk JM, Giles FJ: Liposomal daunorubicin (DaunoXome) plus dexamethasone for patients with multiple myeloma. A phase II International Oncology Study Group study. Cancer; 2002 May 15;94(10):2645-52
Hazardous Substances Data Bank. DEXAMETHASONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liposomal daunorubicin (DaunoXome) plus dexamethasone for patients with multiple myeloma. A phase II International Oncology Study Group study.
  • BACKGROUND: Liposomal daunorubicin is an effective cytotoxic agent in patients with Kaposi sarcoma and hematologic malignancies.
  • Anthracycline-based chemotherapy regimens, such as vincristine/doxorubicin/dexamethasone (VAD), are standard in the treatment of patients with multiple myeloma (MM).
  • Thus, an open-label, Phase II clinical study was conducted by the International Oncology Study Group to assess the efficacy and safety of intravenous liposomal daunorubicin at a dose of 100 mg/m2 given every 3 weeks for a maximum of 6 cycles in patients with recently diagnosed MM (n = 4 patients) or recurrent/refractory MM (n = 37 patients).
  • METHODS: Liposomal daunorubicin was administered as a single agent for the initial two cycles of therapy, and dexamethasone was added to all subsequent cycles.
  • RESULTS: A partial response was achieved in six patients (17%), including one patient with disease that previously was refractory to VAD therapy.
  • The median survival in 35 patients with recurrent disease was 7.6 months.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Antineoplastic Agents, Hormonal / administration & dosage. Daunorubicin / administration & dosage. Dexamethasone / administration & dosage. Multiple Myeloma / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Drug Therapy, Combination. Female. Humans. Liposomes. Male. Middle Aged

  • Genetic Alliance. consumer health - Multiple myeloma.
  • MedlinePlus Health Information. consumer health - Multiple Myeloma.
  • Hazardous Substances Data Bank. DAUNORUBICIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12173332.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Hormonal; 0 / Liposomes; 7S5I7G3JQL / Dexamethasone; ZS7284E0ZP / Daunorubicin
  •  go-up   go-down


8. Osawa R, Kato N, Yanagi T, Yamane N: Clearance of recurrent, classical Kaposi's sarcoma using multiple paclitaxel treatments. Acta Derm Venereol; 2007;87(5):435-6
Hazardous Substances Data Bank. TAXOL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clearance of recurrent, classical Kaposi's sarcoma using multiple paclitaxel treatments.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Neoplasm Recurrence, Local / drug therapy. Paclitaxel / therapeutic use. Sarcoma, Kaposi / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Drug Administration Schedule. Humans. Male. Middle Aged. Remission Induction

  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17721656.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
  •  go-up   go-down


9. Dhillon T, Stebbing J, Bower M: Paclitaxel for AIDS-associated Kaposi's sarcoma. Expert Rev Anticancer Ther; 2005 Apr;5(2):215-9
Hazardous Substances Data Bank. TAXOL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paclitaxel for AIDS-associated Kaposi's sarcoma.
  • Treatment options are limited for patients with advanced acquired immunodeficiency syndrome-related Kaposi's sarcoma (AIDS-KS).
  • The management of early stage cutaneous AIDS-KS has been revolutionized by the introduction of highly active antiretroviral therapy and for most patients highly active antiretroviral therapy alone will control early stage AIDS-KS.
  • However, patients with advanced stage Kaposi's sarcoma with visceral disease, tumor-associated edema or extensive oral disease require systemic chemotherapy in addition to antiretrovirals.
  • The standard first-line therapy for these affected individuals is a liposomal anthracycline, and response rates of around 70% are usually achieved.
  • For patients with refractory or recurrent AIDS-KS, treatment algorithms are less well defined.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Antineoplastic Agents, Phytogenic / therapeutic use. Paclitaxel / therapeutic use. Sarcoma, Kaposi / drug therapy. Sarcoma, Kaposi / virology
  • [MeSH-minor] Algorithms. Anti-Retroviral Agents / therapeutic use. Herpesviridae Infections / complications. Humans. Neoplasm Recurrence, Local / drug therapy. Neoplasm Staging. Prognosis

  • Genetic Alliance. consumer health - AIDS-HIV.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • HIV InSite. treatment guidelines - Human Herpesvirus-8 .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15877519.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents; 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
  • [Number-of-references] 54
  •  go-up   go-down


10. Boeckle E, Boesmueller C, Wiesmayr S, Mark W, Rieger M, Tabarelli D, Graziadei I, Hoefer D, Antretter H, Stelzmueller I, Krugmann J, Zangerle R, Huemer H, Poelzl G, Margreiter R, Bonatti H: Kaposi sarcoma in solid organ transplant recipients: a single center report. Transplant Proc; 2005 May;37(4):1905-9
MedlinePlus Health Information. consumer health - Liver Transplantation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Kaposi sarcoma in solid organ transplant recipients: a single center report.
  • BACKGROUND: Human herpes virus (HHV8) is associated with Castleman's disease, primary effusion lymphoma, and the Kaposi's sarcoma (KS).
  • The heart recipient developed a tumor on the planta pedis; one renal recipient, on both legs.
  • Treatment in all cases consisted of reduction in immunosuppression, together with surgery (n = 1), chemotherapy (n = 1), or irradiation (n = 2).
  • One renal recipient died without evidence of recurrent disease from myocardial infarction.
  • The cardiac and two renal recipients are alive between 4 months and 17 years with well-functioning grafts and no evidence of recurrent disease.
  • Nevertheless, awareness of KS is important for early diagnosis and optimal treatment.
  • [MeSH-major] Heart Transplantation / physiology. Kidney Transplantation / physiology. Liver Transplantation / physiology. Sarcoma, Kaposi / complications. Sarcoma, Kaposi / therapy
  • [MeSH-minor] Adult. Drug Therapy, Combination. Female. Humans. Immunosuppression / methods. Immunosuppressive Agents / therapeutic use. Male. Middle Aged. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Heart Transplantation.
  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • MedlinePlus Health Information. consumer health - Kidney Transplantation.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15919500.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  •  go-up   go-down


11. Gabizon AA: Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest; 2001;19(4):424-36
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy.
  • Pegylated liposomal doxorubicin (Doxil, Caelyx) is a formulation of doxorubicin in poly(ethylene glycol)-coated (stealth) liposomes with a prolonged circulation time and unique toxicity profile.
  • We review the preclinical and clinical pharmacology as well as recent clinical data obtained in specific cancer types.
  • Doxil liposomes retain the drug payload during circulation and accumulate preferentially in tissues with increased microvascular permeability, as often is the case of tumors.
  • Doxil is probably one of the most active agents in AIDS-related Kaposi's sarcoma and has a definite role in management of recurrent ovarian cancer.
  • The potential of Doxil in the treatment of other cancer types and the opportunities it offers in combination with other drugs and therapeutic modalities are under active investigation.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Doxorubicin / therapeutic use
  • [MeSH-minor] Acquired Immunodeficiency Syndrome / complications. Alopecia / chemically induced. Anaphylaxis / chemically induced. Animals. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow Diseases / chemically induced. Breast Neoplasms / drug therapy. Cardiomyopathies / chemically induced. Clinical Trials, Phase I as Topic. Clinical Trials, Phase II as Topic. Clinical Trials, Phase III as Topic. Dogs. Drug Carriers. Drug Eruptions / etiology. Drug Hypersensitivity / etiology. Drug Synergism. Female. Forecasting. Half-Life. Humans. Lethal Dose 50. Liposomes. Macrophages / metabolism. Maximum Tolerated Dose. Mice. Mononuclear Phagocyte System / metabolism. Nausea / chemically induced. Neoplasms / drug therapy. Neoplasms, Experimental / drug therapy. Ovarian Neoplasms / drug therapy. Rats. Retrospective Studies. Sarcoma, Kaposi / drug therapy. Sarcoma, Kaposi / etiology. Solubility. Stomatitis / chemically induced. Suspensions. Tissue Distribution. Xenograft Model Antitumor Assays

  • HIV InSite. treatment guidelines - Human Herpesvirus-8 .
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11405181.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Drug Carriers; 0 / Liposomes; 0 / Suspensions; 80168379AG / Doxorubicin
  •  go-up   go-down


12. Tardivo JP, Del Giglio A, Paschoal LH, Baptista MS: New photodynamic therapy protocol to treat AIDS-related Kaposi's sarcoma. Photomed Laser Surg; 2006 Aug;24(4):528-31
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New photodynamic therapy protocol to treat AIDS-related Kaposi's sarcoma.
  • OBJECTIVE: The aim of this study was to evaluate the efficiency of photodynamic therapy (PDT) with phenotiazinium compounds (methylene blue and toluidine blue) and excitation by a non-coherent light source (RL50) to treat AIDS-related Kaposi's sarcoma (Sk-AIDS).
  • BACKGROUND DATA: Sk-AIDS is a malignant disease that is recurrent in AIDS patients.
  • METHODS: A single patient with multiple lesions who had undergone chemotherapy without success was treated with several applications of PDT, and the patient was closely evaluated.
  • [MeSH-major] HIV Infections / complications. Photochemotherapy / methods. Sarcoma, Kaposi / drug therapy. Skin Neoplasms / drug therapy

  • Genetic Alliance. consumer health - AIDS-HIV.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16942436.001).
  • [ISSN] 1549-5418
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


13. Ramon I, Libert M, Guillaume MP, Corazza F, Karmali R: Recurrent haemophagocytic syndrome in an HIV-infected patient. Acta Clin Belg; 2010 Jul-Aug;65(4):276-8
MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent haemophagocytic syndrome in an HIV-infected patient.
  • We describe a case of recurrent haemophagocytic syndrome (HS) in an HIV-infected patient.The first episode was associated with active human herpesvirus 8 infection and progressive Kaposi's sarcoma which was successfully treated with splenectomy, foscarnet and chemotherapy.
  • The second episode was triggered by a Clostridium difficile colitis and resolved completely after treatment with metronidazole only.
  • Recurrent HS has rarely been described in adult patients out of the setting of relapsing malignancy or autoimmune disease.The chronic immune dysregulation and suppression due to HIV-infection may predispose our patient to development of associated HS.
  • Rapidly unmasking the causative factor and timely instauration of adequate treatment are critical and may improve outcome.
  • [MeSH-major] AIDS-Related Opportunistic Infections / diagnosis. Lymphohistiocytosis, Hemophagocytic / diagnosis. Sarcoma, Kaposi / diagnosis

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - HIV/AIDS and Infections.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20954469.001).
  • [ISSN] 1784-3286
  • [Journal-full-title] Acta clinica Belgica
  • [ISO-abbreviation] Acta Clin Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  •  go-up   go-down


14. Mankan N, Madhunapantala S, Maini A: An unusual presentation of body cavity lymphoma. J Clin Oncol; 2004 Jul 15;22(14_suppl):6699

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 6699 Background: BCL (Body Cavity Lymphoma) is an uncommon primary NHL (Non-Hodgkin's lymphoms) that proliferates within serous body cavities - pleural, pericardial or peritoneal, resulting in recurrent effusions.
  • In the absence of HIV infection, it almost universally develops in the background of HHV-8/KSHV (Human Herpes Virus-8/ Kaposi's Sarcoma Herpes Virus) infection with or without EBV (Epstein Barr Virus).
  • He is heterosexual, monogamous, non-smoker and denied alcohol or intravenous drug abuse.
  • Pleural fluid was frankly hemorrhagic with 80,000 RBC/cu mm, 16,800 WBC/ cu mm with 65% lymphocytes and 26% monocytes.
  • He underwent therapeutic thoracentesis with relief of respiratory symptoms.Standard CHOP-like chemotherapy has been planned for this patient.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28014390.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


15. Harsch IA, Kraetsch HG, Amann K, Hahn EG, Ficker JH, Konturek PC: Disseminated manifestation of Kaposi's Sarcoma in newly diagnosed AIDS in an african female. Med Sci Monit; 2001 Nov-Dec;7(6):1303-6
Hazardous Substances Data Bank. STAVUDINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disseminated manifestation of Kaposi's Sarcoma in newly diagnosed AIDS in an african female.
  • BACKGROUND: Kaposi's sarcomas are the most frequent malignancies in patients with AIDS and there is increasing evidence of an association with human Herpesvirus 8 (HHV-8).
  • A reconstitution of the immune response due to different regimens of highly active antiretroviral therapy (HAART) is the most important step in treatment of Kaposi's sarcomas.
  • Local treatment options include the topic application of alitretionin (9-cis-retinoic acid) as a gel, cryotherapy with liquid nitrogen and intralesional vinblastine, as well as local laser or low-dose X-ray treatment.
  • A systemic chemotherapy can be taken under consideration in selected cases with clinical significant visceral lesions or aggressive sarcomatous behavior with anthracyclines, taxanes, as well as an immunomodulatory treatment with alpha Interferon.
  • Hospitalized due to recurrent fever and diarrhea, the diagnosis of AIDS was quickly established.
  • The physical examination revealed multiple nodular, painless skin lesions suspicious of Kaposi's sarcoma.
  • In patients with HIV-infection, nodular skin lesions should lead suspicion to Kaposi's sarcoma.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Sarcoma, Kaposi / complications
  • [MeSH-minor] AIDS Serodiagnosis. Adult. Benzoxazines. Drug Therapy, Combination. Female. Humans. Interferon-alpha / therapeutic use. Lamivudine / administration & dosage. Lamivudine / therapeutic use. Nelfinavir / administration & dosage. Nelfinavir / therapeutic use. Oxazines / administration & dosage. Oxazines / therapeutic use. Reverse Transcriptase Inhibitors / administration & dosage. Reverse Transcriptase Inhibitors / therapeutic use. Stavudine / administration & dosage. Stavudine / therapeutic use


16. Brambilla L, Labianca R, Ferrucci SM, Taglioni M, Boneschi V: Treatment of classical Kaposi's sarcoma with gemcitabine. Dermatology; 2001;202(2):119-22
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of classical Kaposi's sarcoma with gemcitabine.
  • BACKGROUND: Several drugs are active in aggressive classical Kaposi's sarcoma (CKS); chemotherapeutic agents with fewer side-effects, more rapid response and able to overcome resistance to previous treatment are advisable when treating patients in a second line.
  • Gemcitabine, an analogue of deoxycytidine with cytotoxic activity in the treatment of solid tumours, has been found to have no serious side-effects.
  • METHODS: Twelve patients with a recurrent aggressive form of CKS previously treated with chemotherapy were treated with gemcitabine.
  • The drug was administered intravenously at the dose of 1.2 g/week for 2 weeks, followed by a 1-week interval, until maximal response was reached.
  • CONCLUSION: This study shows the usefulness of treating patients affected with aggressive CKS with gemcitabine, in order to obtain control of the disease and to reduce the related symptoms as well as to overcome a possible resistance to previous treatments.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / therapeutic use. Sarcoma, Kaposi / drug therapy. Skin Neoplasms / drug therapy

  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2001 S. Karger AG, Basel.
  • (PMID = 11306832.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
  •  go-up   go-down


17. Boratyńska M, Zmonarski SC, Klinger M: Reccurence of Kaposi's sarcoma after increased exposure to sirolimus. Int Immunopharmacol; 2006 Dec 20;6(13-14):2018-22
Hazardous Substances Data Bank. SIROLIMUS .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reccurence of Kaposi's sarcoma after increased exposure to sirolimus.
  • The conversion to sirolimus treatment is recently indicated as an effective therapy of Kaposi's sarcoma (KS) in transplant patients.
  • We present two treatment modalities in patients with KS and recurrence of the disease after increasing sirolimus dose.
  • Two patients developed cutaneous tumor; one disseminated disease, including the skin, mediastinal lymph nodes and both lungs.
  • After histological confirmation of KS immunosuppression was minimized: Two were converted to sirolimus (1-2 mg/day, level 5-8 ng/ml) treatment; the third patient discontinued tacrolimus and was administered 1 g/day mycophenolate mofetil.
  • Recurrent disease developed afterwards involving diffuse interstitial infiltrates with nodular changes in both lungs.
  • For the second time the dose of sirolimus was reduced to 1 mg/day (level 4-5 ng/ml) and lung lesions regressed 5 months later.
  • IN CONCLUSION: treatment by low sirolimus or mycophenolate mofetil doses caused regression of KS.
  • [MeSH-major] Kidney Transplantation. Sarcoma, Kaposi / chemically induced. Sirolimus / adverse effects
  • [MeSH-minor] Drug Therapy, Combination. Female. Humans. Immunosuppression / adverse effects. Immunosuppressive Agents / adverse effects. Immunosuppressive Agents / therapeutic use. Male. Middle Aged. Mycophenolic Acid / adverse effects. Mycophenolic Acid / analogs & derivatives. Mycophenolic Acid / therapeutic use. Neoplasm Recurrence, Local

  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • MedlinePlus Health Information. consumer health - Kidney Transplantation.
  • Hazardous Substances Data Bank. MYCOPHENOLATE MOFETIL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17161356.001).
  • [ISSN] 1567-5769
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 9242ECW6R0 / mycophenolate mofetil; HU9DX48N0T / Mycophenolic Acid; W36ZG6FT64 / Sirolimus
  •  go-up   go-down


18. Roberts MS, Wu ZY, Siebert GA, Anissimov YG, Thompson JF, Smithers BM: Pharmacokinetics and pharmacodynamics of melphalan in isolated limb infusion for recurrent localized limb malignancy. Melanoma Res; 2001 Aug;11(4):423-31
Hazardous Substances Data Bank. MELPHALAN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pharmacokinetics and pharmacodynamics of melphalan in isolated limb infusion for recurrent localized limb malignancy.
  • It has a lower morbidity in treating localized recurrences and in transit metastases of the limb for tumours such as melanoma, Merkel cell tumour and Kaposi's sarcoma, allowing administration of high concentrations of cytotoxic agent to the affected limb under hypoxic conditions.
  • Melphalan is the preferred cytotoxic agent for the treatment of melanoma by ILP or ILI.
  • The kinetics of drug distribution in the limb was calculated using a two-compartment vascular model, where both tissue and infusate act as well-stirred compartments.
  • Recirculation and wash-out flow rates, tissue concentrations and the permeability surface area product (PS) were calculated.
  • Correlations between the PS value and the drug concentrations in the perfusate and tissue were supported by the results.
  • These data contribute to a better understanding of the distribution of melphalan during ILI in the limb, and offer the opportunity to optimize the drug regimen for patients undergoing ILI.
  • [MeSH-major] Infusion Pumps. Leg. Melphalan / pharmacokinetics. Melphalan / therapeutic use. Neoplasm Recurrence, Local / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antineoplastic Agents, Alkylating / administration & dosage. Antineoplastic Agents, Alkylating / pharmacokinetics. Antineoplastic Agents, Alkylating / therapeutic use. Carcinoma, Merkel Cell / drug therapy. Carcinoma, Merkel Cell / pathology. Dose-Response Relationship, Drug. Female. Humans. Male. Melanoma / drug therapy. Melanoma / pathology. Middle Aged. Models, Biological. Sarcoma, Kaposi / drug therapy. Sarcoma, Kaposi / pathology. Time Factors

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11479432.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; Q41OR9510P / Melphalan
  •  go-up   go-down


19. Dezube BJ, Krown SE, Lee JY, Bauer KS, Aboulafia DM: Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study. J Clin Oncol; 2006 Mar 20;24(9):1389-94
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study.
  • PURPOSE: Matrix metalloproteinases (MMPs) are involved in tumor metastasis and are overexpressed in Kaposi's sarcoma (KS) cells.
  • In a phase I trial of the MMP inhibitor COL-3 in patients with AIDS-related KS, the drug was well tolerated, KS regression was observed, and MMP-2 levels decreased significantly in responders compared with nonresponders.
  • Antiretroviral therapy was permitted but not required.
  • Study end points were progressive KS and recurrent dose-limiting toxicity.
  • Fifty-seven patients (76%) had received prior KS therapy.
  • There were significant declines in MMP-2 and MMP-9 plasma levels from baseline to minimum value with treatment (MMP-2, P < .001; MMP-9, P = .001).
  • CONCLUSION: COL-3, when administered as 50 mg/d, is both active and well tolerated in the treatment of AIDS-related KS.
  • COL-3 is a promising agent for the treatment of this opportunistic neoplasm of AIDS.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Sarcoma, Kaposi / drug therapy. Tetracyclines / therapeutic use
  • [MeSH-minor] Administration, Oral. Adult. Aged. Disease Progression. Female. Humans. Male. Matrix Metalloproteinase 2 / blood. Matrix Metalloproteinase 9 / blood. Middle Aged. Treatment Outcome

  • Genetic Alliance. consumer health - AIDS-HIV.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16549833.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U01CA070019; United States / NCI NIH HHS / CA / U01CA070047; United States / NCI NIH HHS / CA / U01CA070054; United States / NCI NIH HHS / CA / U01CA070062; United States / NCI NIH HHS / CA / U01CA070072; United States / NCI NIH HHS / CA / U01CA070079; United States / NCI NIH HHS / CA / U01CA070080; United States / NCI NIH HHS / CA / U01CA071375; United States / NCI NIH HHS / CA / U01CA083038; United States / NCI NIH HHS / CA / U01CA083118; United States / NCI NIH HHS / CA / U01CA083216; United States / NCI NIH HHS / CA / U01CA70058; United States / NCI NIH HHS / CA / U01CA70081
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tetracyclines; 0 / tetracycline CMT-3; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
  •  go-up   go-down


20. Régnier-Rosencher E, Barrou B, Marcelin AG, Jacobzone-Leveque C, Cadranel J, Leblond V, Francès C: [Primary effusion lymphoma in two kidney transplant recipients]. Ann Dermatol Venereol; 2010 Apr;137(4):285-9
MedlinePlus Health Information. consumer health - Kidney Transplantation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Lymphome des séreuses chez le transplanté rénal: deux cas.
  • BACKGROUND: Primary effusion lymphoma (PEL) is a highly malignant non-Hodgkin lymphoma associated with Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 infection (KSHV/HHV-8).
  • OBSERVATION: We describe two male kidney transplant recipients, aged 47 and 51 years, followed for Kaposi's sarcoma in skin, lymph nodes, gastrointestinal (GI) tract and lung whose disease was poorly controlled by sirolimus and chemotherapy.
  • Recurrent pleural effusion contrasted with reduction of cutaneous Kaposi lesions.
  • CONCLUSION: The contrast between a very low KHSV viral load in plasma and a very high viral load pleural effusion should alert physicians and prompt suspicion of PEL in Kaposi's sarcoma patients with recurrent serous effusion.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Epstein-Barr Virus Infections / etiology. Herpesvirus 4, Human / isolation & purification. Herpesvirus 8, Human / isolation & purification. Immunosuppressive Agents / adverse effects. Kidney Transplantation. Lymphoma, Primary Effusion / etiology. Neoplasms, Multiple Primary / etiology. Postoperative Complications / etiology
  • [MeSH-minor] Digestive System Neoplasms / drug therapy. Digestive System Neoplasms / secondary. Digestive System Neoplasms / virology. Fatal Outcome. Giant Lymph Node Hyperplasia / complications. Giant Lymph Node Hyperplasia / virology. Humans. Immunocompromised Host. Kidney Failure, Chronic / etiology. Kidney Failure, Chronic / surgery. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Lung Neoplasms / virology. Lymphatic Metastasis. Male. Middle Aged. Pleural Effusion, Malignant / cytology. Pleural Effusion, Malignant / virology. Sarcoma, Kaposi / drug therapy. Sarcoma, Kaposi / etiology. Sarcoma, Kaposi / virology. Skin Neoplasms / drug therapy. Skin Neoplasms / etiology. Skin Neoplasms / virology. Viral Load

  • Genetic Alliance. consumer health - Primary effusion lymphoma.
  • MedlinePlus Health Information. consumer health - After Surgery.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20417362.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  •  go-up   go-down


21. Flaitz CM, Nichols CM, Walling DM, Hicks MJ: Plasmablastic lymphoma: an HIV-associated entity with primary oral manifestations. Oral Oncol; 2002 Jan;38(1):96-102
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present a 50 year-old HIV-positive, bisexual, white male with a CD4 count 300/mm(3) and a viral HIV-RNA polymerase chain reaction (PCR) load of 237 copies/ml, who developed a painful, purple-red mass in the edentulous area of the maxillary right first molar.
  • In addition, the patient was being managed with antiretroviral therapy and liposomal doxorubicin for recurrent cutaneous Kaposi's sarcoma (KS).
  • Although oral KS was suspected, the gingival lesions were biopsied because they were refractory to chemotherapy and a lymphoma could not be excluded.
  • [MeSH-minor] Antiretroviral Therapy, Highly Active / methods. Diagnosis, Differential. Epstein-Barr Virus Infections / complications. Fatal Outcome. HIV Infections / drug therapy. Humans. Male. Middle Aged. Sarcoma, Kaposi / diagnosis


22. Ives NJ, Gazzard BG, Easterbrook PJ: The changing pattern of AIDS-defining illnesses with the introduction of highly active antiretroviral therapy (HAART)in a London clinic. J Infect; 2001 Feb;42(2):134-9
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The changing pattern of AIDS-defining illnesses with the introduction of highly active antiretroviral therapy (HAART)in a London clinic.
  • OBJECTIVES: To quantify the progressive impact of combination antiretroviral therapy (ART) on the incidence of AIDS-defining illnesses (ADIs) over a 9-year period.
  • Incidence rates for the 12 most frequent ADIs were compared for two time periods, 1990-1995 (pre-HAART) and 1996-1998 (post-HAART), using Poisson regression methods.
  • RESULTS: After a median follow-up of 35 months, 450 (29%) patients had developed AIDS.
  • Between the two time periods there was a significant decrease in the incidence of Pneumocystis carinii pneumonia (PCP) by 35% (4.11 per 100 person-years in 1990-1995 vs. 2.67 in 1996-1998;P= 0.007), Kaposi's sarcoma by 34% (3.27 vs. 2.17;P= 0.022) and cryptosporidiosis by 60% (0.76 vs. 0.31;P= 0.029).
  • The incidence of cerebral toxoplasmosis, cytomegalovirus, recurrent bacterial chest infections and dementia remained stable.
  • There was a clear stepwise reduction in the incidence of PCP, Kaposi's sarcoma and cryptosporidiosis with the use of non-H AART and HAART regimens relative to no ART.
  • In a multivariate analysis, the use of ART and HAART explained the progressive decrease in incidence of PCP and Kaposi's sarcoma.
  • The striking reduction in the inci-dence of PCP and Kaposi's sarcoma since 1996 can be attributed to the use of combination ART and particularly HAART.
  • [MeSH-major] AIDS-Related Opportunistic Infections / epidemiology. Acquired Immunodeficiency Syndrome / drug therapy. Anti-HIV Agents / therapeutic use. Antiretroviral Therapy, Highly Active. HIV-1
  • [MeSH-minor] Adult. Animals. Candidiasis / epidemiology. Cohort Studies. Cryptosporidiosis / epidemiology. Cryptosporidiosis / etiology. Cryptosporidium. Drug Therapy, Combination. Female. Humans. Incidence. London / epidemiology. Lymphoma, Non-Hodgkin / epidemiology. Male. Mycobacterium avium Complex. Mycobacterium avium-intracellulare Infection / epidemiology. Mycobacterium tuberculosis. Pharyngeal Diseases / epidemiology. Pneumonia, Pneumocystis / epidemiology. Pneumonia, Pneumocystis / etiology. Retrospective Studies. Sarcoma, Kaposi / epidemiology. Sarcoma, Kaposi / etiology. Tuberculosis / epidemiology. Tuberculosis / etiology


23. Duggal MS, Abudiak H, Dunn C, Tong HJ, Munyombwe T: Effect of CD4+ lymphocyte count, viral load, and duration of taking anti-retroviral treatment on presence of oral lesions in a sample of South African children with HIV+/AIDS. Eur Arch Paediatr Dent; 2010 Oct;11(5):242-6
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of CD4+ lymphocyte count, viral load, and duration of taking anti-retroviral treatment on presence of oral lesions in a sample of South African children with HIV+/AIDS.
  • AIMS: This was to determine the presence and types of oral mucosal lesions in a sample of HIV(+)/AIDS South African children taking antiretroviral therapy and to investigate the relationship between CD4(+) lymphocyte counts, viral load, duration of taking antiretroviral therapy (DART), and age on presence of oral lesions.
  • RESULTS: Oral Candidiasis was the most common lesion reported in 19/56 children, followed by Recurrent Herpetic Infection in 9 children.
  • Other lesions such as Kaposi's sarcoma, Multifocal Epithelial Hyperplasia, Oral Hairy Leukoplakia, Linear Gingival Erythema, and oral ulceration were also present.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / drug therapy. Anti-Retroviral Agents / therapeutic use. CD4 Lymphocyte Count. HIV Infections / drug therapy. HIV Seropositivity / drug therapy. Mouth Diseases / diagnosis. Viral Load / classification
  • [MeSH-minor] AIDS-Related Opportunistic Infections / diagnosis. Adolescent. Age Factors. Candidiasis, Oral / diagnosis. Child. Child, Preschool. Erythema / diagnosis. Female. Focal Epithelial Hyperplasia / diagnosis. Gingival Diseases / epidemiology. Humans. Infant. Leukoplakia, Hairy / diagnosis. Male. Mouth Neoplasms / diagnosis. Sarcoma, Kaposi / diagnosis. South Africa. Stomatitis, Herpetic / diagnosis. Time Factors

  • Genetic Alliance. consumer health - AIDS-HIV.
  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - HIV/AIDS in Women.
  • MedlinePlus Health Information. consumer health - HIV/AIDS Medicines.
  • MedlinePlus Health Information. consumer health - Mouth Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] AIDS Patient Care STDS. 2003 Jan;17(1):5-11 [12614515.001]
  • [Cites] J Oral Pathol Med. 2008 Feb;37(2):99-106 [18197855.001]
  • [Cites] East Afr Med J. 2007 Aug;84(8):383-8 [17970007.001]
  • [Cites] Pediatr Dent. 2000 Jul-Aug;22(4):287-91 [10969432.001]
  • [Cites] Oral Dis. 2004 Nov;10(6):319-26 [15533205.001]
  • [Cites] Oral Dis. 2002;8 Suppl 2:110-4 [12164643.001]
  • [Cites] Oral Dis. 2004 May;10(3):138-44 [15089922.001]
  • [Cites] Oral Dis. 2004 May;10(3):145-50 [15089923.001]
  • [Cites] Oral Dis. 2004 Jan;10(1):13-8 [14996288.001]
  • [Cites] AIDS Patient Care STDS. 2002 Apr;16(4):151-6 [12015869.001]
  • [Cites] J Oral Pathol Med. 1993 Aug;22(7):289-91 [8229864.001]
  • [Cites] BMC Oral Health. 2006 Aug 18;6:12 [16916469.001]
  • [Cites] J Oral Pathol Med. 2007 Mar;36(3):136-41 [17305634.001]
  • [Cites] Oral Dis. 2002;8 Suppl 2:49-54 [12164660.001]
  • [Cites] Science. 1996 May 24;272(5265):1167-70 [8638160.001]
  • [Cites] Oral Dis. 2006 Jul;12(4):402-7 [16792726.001]
  • [Cites] Curationis. 2007 Mar;30(1):56-61 [17515317.001]
  • [Cites] J Public Health Dent. 2008 Summer;68(3):178-81 [18248345.001]
  • [Cites] Oral Dis. 1997 May;3 Suppl 1:S31-5 [9456653.001]
  • [Cites] Adv Dent Res. 2006 Apr 01;19(1):63-8 [16672552.001]
  • [Cites] N Engl J Med. 2001 Nov 22;345(21):1522-8 [11794218.001]
  • [Cites] J Clin Pediatr Dent. 1999 Winter;23(2):85-96 [10204447.001]
  • [Cites] Int J Dermatol. 2006 Mar;45(3):280-4 [16533229.001]
  • [Cites] AIDS. 1999 Oct 22;13(15):2174-6 [10546876.001]
  • [Cites] Am J Public Health. 1995 Aug;85(8 Pt 1):1076-81 [7625499.001]
  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Aug;108(2):203-10 [19615660.001]
  • [Cites] Int J Pediatr Otorhinolaryngol. 2006 Jun;70(6):1089-96 [16406081.001]
  • [Cites] J Oral Pathol Med. 2009 Sep;38(8):613-22 [19614862.001]
  • [Cites] Ann Intern Med. 1997 Jun 15;126(12):946-54 [9182471.001]
  • [Cites] J Acquir Immune Defic Syndr. 2005 Jan 1;38(1):87-95 [15608531.001]
  • [Cites] Rev Laryngol Otol Rhinol (Bord). 2002;123(4):231-4 [12723487.001]
  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Aug;90(2):182-8 [10936837.001]
  • [Cites] AIDS. 1991 Nov;5(11):1339-43 [1768382.001]
  • [Cites] J Oral Pathol Med. 2001 Oct;30(9):549-52 [11555158.001]
  • (PMID = 20932399.001).
  • [ISSN] 1818-6300
  • [Journal-full-title] European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
  • [ISO-abbreviation] Eur Arch Paediatr Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents
  •  go-up   go-down


24. Potti A, Malik AA, Ganti AK, Koch M, Leitch J: Immunoglobulin and T-cell receptor gene-gene rearrangement in pleural cavity-based T-cell rich B-cell lymphoma in an immunocompetent patient. Leuk Lymphoma; 2002 Jan;43(1):195-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This almost exclusively occurs in patients with acquired immunodeficiency syndrome (AIDS), who invariably have a history of Kaposi sarcoma.
  • We report a rare case of a recurrent pleural effusion in an immunocompetent patient.
  • There was no evidence of lymphadenopathy or an associated mass on computerized tomography of the chest, abdomen and pelvis.
  • Cytologic examination of the pleural fluid showed an elevated white cell count with 97% lymphocytes, mostly with T-cell markers.
  • The patient responded to combination chemotherapy with cyclophosphamide, adriamycin, vincristine and prednisone.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 11908729.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


25. Di Benedetto F, Di Sandro S, De Ruvo N, Berretta M, Montalti R, Guerrini GP, Ballarin R, De Blasiis MG, Spaggiari M, Smerieri N, Iemmolo RM, Guaraldi G, Gerunda GE: Human immunodeficiency virus and liver transplantation: our point of view. Transplant Proc; 2008 Jul-Aug;40(6):1965-71
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Highly active antiretroviral therapy (HAART) has been able to improve the immune system function and survival of HIV patients with a consequent increase in the number of HIV patients affected by end-stage liver disease (ESLD).
  • METHODS: All patients were treated with HAART before transplantation; treatment was interrupted on transplantation day and was restarted once the patients' conditions stabilized.
  • Four patients suffered from a cholestatic HCV recurrent hepatitis treated with antiviral therapy (peginterferon and Ribavirin).
  • DISCUSSION: The outcome of liver transplantation in HIV patients was influenced by infections (HCV, CMV, and EBV) and Kaposi's Sarcoma.
  • Drug interaction between HAART and immunosuppressants occurs; longer follow-up and better experience may improve the management of these drug interactions.
  • [MeSH-major] HIV Infections / complications. Hepatitis C / complications. Hepatitis C / surgery. Immunosuppressive Agents / therapeutic use. Liver Failure / complications. Liver Failure / surgery. Liver Transplantation / contraindications. Liver Transplantation / methods
  • [MeSH-minor] Adult. Antiretroviral Therapy, Highly Active. CD4 Lymphocyte Count. Female. HIV Seropositivity. Humans. Male. Middle Aged. Sarcoma, Kaposi. Tissue Donors. alpha-Fetoproteins / analysis


26. Baccaglini L, Atkinson JC, Patton LL, Glick M, Ficarra G, Peterson DE: Management of oral lesions in HIV-positive patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Mar;103 Suppl:S50.e1-23
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This systematic review of the literature was conducted to evaluate the evidence for treatment of the most common oral lesions associated with HIV: oral candidiasis with or without oropharyngeal involvement (OPC), oral hairy leukoplakia (OHL), recurrent aphthous-like ulcerations (RAU), oral Kaposi's sarcoma (OKS), orolabial herpes simplex infection (HSV), oral herpes zoster infection (VZV), intraoral or perioral warts (HPV), and HIV-associated periodontal diseases.
  • Treatment of HIV-associated salivary gland disease is addressed in a different section of this World Workshop.
  • We found the largest body of evidence for treatment of OPC in HIV patients.
  • Future trials will be needed to test drugs currently in development for treatment of Candida strains that are resistant to existing therapies.
  • There were no double blind, placebo-controlled randomized clinical trials (RCT) for topical treatment of OHL, and only one RCT for systemic treatment of the lesion with desciclovir.
  • Systemic thalidomide was the only drug tested in RCT for treatment or prevention of RAU.
  • Only 1 double-blind RCT comparing vinblastine and sodium tetradecyl sulfate was identified for localized treatment of OKS.
  • Three drugs (famciclovir, acyclovir, and valaciclovir) were shown to be effective in randomized, double-blind trials for treatment or suppression of mucocutaneous HSV lesions in HIV patients.
  • In all 3 trials, the effects of these medications on orolabial HSV lesions were not reported separately.
  • There were no double-blind, placebo-controlled RCT testing topical treatments for orolabial HSV lesions in HIV patients.
  • No trials testing treatments of oral VZV were identified.
  • There were no double-blind, placebo-controlled RCT for treatment of HIV-associated intraoral or perioral warts or periodontal diseases.
  • In conclusion, there is a need for well-designed RCTs to assess the safety and efficacy of topical and systemic treatments of most oral mucosal and perioral lesions in HIV patients.
  • There is also a need to develop newer drugs for treatment of resistant fungal and viral microorganisms.
  • Finally, standardized outcome measures should be developed for future clinical trials to allow comparisons of studies using different populations.
  • [MeSH-major] HIV Infections / complications. Herpes Simplex / drug therapy. Mouth Diseases / drug therapy. Sarcoma, Kaposi / drug therapy
  • [MeSH-minor] Antiviral Agents / therapeutic use. Humans. Mouth Neoplasms / drug therapy. Mouth Neoplasms / virology. Periodontitis / virology. Warts / therapy. Warts / virology

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Herpes Simplex.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - Kaposi's Sarcoma.
  • MedlinePlus Health Information. consumer health - Mouth Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17379155.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / R13 DE016480
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents
  • [Number-of-references] 187
  •  go-up   go-down


27. Tan HH, Goh CL: Viral infections affecting the skin in organ transplant recipients: epidemiology and current management strategies. Am J Clin Dermatol; 2006;7(1):13-29
Hazardous Substances Data Bank. L-Valine .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • HHV that are important in this group of patients are herpes simplex virus (HSV) types 1 and 2, varicella-zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), HHV-6 and -7, and HHV-8, which causes Kaposi sarcoma (KS).
  • Treatment is usually with acyclovir, valaciclovir, or famciclovir.
  • In organ transplant recipients, recurrent herpes zoster can occur.
  • The present gold standard for treatment is ganciclovir, but newer drugs such as valganciclovir appear promising.
  • [MeSH-major] Antiviral Agents / administration & dosage. Organ Transplantation. Skin Diseases, Viral / diagnosis. Skin Diseases, Viral / drug therapy
  • [MeSH-minor] 2-Aminopurine / administration & dosage. 2-Aminopurine / analogs & derivatives. Acyclovir / administration & dosage. Acyclovir / analogs & derivatives. Cytomegalovirus Infections / diagnosis. Cytomegalovirus Infections / drug therapy. Cytosine / administration & dosage. Cytosine / analogs & derivatives. Drug Administration Schedule. Epstein-Barr Virus Infections / diagnosis. Epstein-Barr Virus Infections / drug therapy. Foscarnet / administration & dosage. Herpes Zoster / diagnosis. Herpes Zoster / drug therapy. Herpesviridae Infections / diagnosis. Herpesviridae Infections / drug therapy. Humans. Immunocompromised Host. Molluscum Contagiosum / diagnosis. Molluscum Contagiosum / drug therapy. Organophosphonates / administration & dosage. Papillomavirus Infections / diagnosis. Papillomavirus Infections / drug therapy. Trifluridine / administration & dosage. Valine / administration & dosage. Valine / analogs & derivatives

  • MedlinePlus Health Information. consumer health - Organ Transplantation.
  • Hazardous Substances Data Bank. Famciclovir .
  • Hazardous Substances Data Bank. CIDOFOVIR .
  • Hazardous Substances Data Bank. Valacyclovir .
  • Hazardous Substances Data Bank. Foscarnet .
  • Hazardous Substances Data Bank. ACYCLOVIR .
  • Hazardous Substances Data Bank. Trifluridine .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16489840.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Organophosphonates; 104227-87-4 / famciclovir; 364P9RVW4X / Foscarnet; 452-06-2 / 2-Aminopurine; 8J337D1HZY / Cytosine; HG18B9YRS7 / Valine; JIL713Q00N / cidofovir; MZ1IW7Q79D / valacyclovir; RMW9V5RW38 / Trifluridine; X4HES1O11F / Acyclovir
  • [Number-of-references] 124
  •  go-up   go-down


28. Aline-Fardin A, Rifle G, Martin L, Justrabo E, Bour JB, D'Athis P, Tanter Y, Mousson C: Recurent and de novo membranous glomerulopathy after kidney transplantation. Transplant Proc; 2009 Mar;41(2):669-71
MedlinePlus Health Information. consumer health - Kidney Transplantation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study was to compare the clinical characteristics of recurrent and de novo membranous glomerulopathy (MG) among a cohort of 614 recipients transplanted between 1989 and 2006.
  • HCV infection, cryoglobulinemia, monoclonal gammopathy, skin cancers, Kaposi sarcoma, diabetes mellitus, anti-HLA antibodies, and graft survival were not significantly different between the groups.
  • Seventeen MG were diagnosed in 15 patients (2.45% of the whole group), including 6 recurrent MG (35%) and 11 de novo MG (75%).
  • Recurrent MG occurred earlier than de novo MG (15.58 +/- 19.13 vs 49.27 +/- 32.71 months).
  • [MeSH-minor] Drug Therapy, Combination. Female. Follow-Up Studies. Graft Survival. Hepatitis C / complications. Hepatitis C / epidemiology. Humans. Immunosuppressive Agents / therapeutic use. Kidney Failure, Chronic / surgery. Male. Recurrence. Reverse Transcriptase Polymerase Chain Reaction. Time Factors

  • Genetic Alliance. consumer health - Transplantation.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19328952.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  •  go-up   go-down


29. Piccoli GB, Quaglia M, Quaglino P, Burdese M, Bermond F, Mezza E, Jeantet A, Segoloni GP: Acute digital gangrene in a long-term dialysis patient -- a diagnostic challenge. Med Sci Monit; 2002 Nov;8(11):CS83-9
Hazardous Substances Data Bank. WARFARIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The differential diagnosis is complex and includes immunological derangement (underlying disease, uremia), vasculopathic-atheroembolic diseases, calciphylaxis, infections, neoplasm, coagulation disorders, and adverse drug effects.
  • CASE REPORT: We report on a 50-year-old male patient with a long follow-up on renal replacement therapy (20 years), currently on daily hemodialysis.
  • The patient's history of kidney transplantation was complicated by seven acute rejection episodes and by Kaposi sarcoma; comorbidity included HLA-B27 positive ankylosing spondylitis, diffuse vascular disease, recurrent atrial fibrillation, chronic hypotension, HCV positivity.
  • Ten days after the start of warfarin for an atrial fibrillation episode, the patient developed digital necrotising ulcerations, rapidly evolving into partial symmetric digital gangrene at distal phalanxes.
  • The timing and evolution of the lesions and the finding of protein S deficiency were the clues for diagnosing warfarin-induced skin necrosis (WISN); the drug was discontinued and therapy with low-molecular weight heparin, plasma and prostacyclin achieved slow resolution of lesions.
  • [MeSH-minor] Anticoagulants / adverse effects. Databases as Topic. Diagnosis, Differential. HLA-B27 Antigen / metabolism. Humans. Male. Middle Aged. Necrosis. Renal Replacement Therapy / adverse effects. Skin / pathology. Spondylitis, Ankylosing / complications. Vascular Diseases / complications. Warfarin / adverse effects

  • MedlinePlus Health Information. consumer health - Gangrene.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 12444385.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / HLA-B27 Antigen; 5Q7ZVV76EI / Warfarin
  •  go-up   go-down






Advertisement