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1. Sah SP, Jain BK, Lakhey M, Rani S: Mucinous carcinoma of rectosigmoid in a 15-year-old child: a case report. Indian J Pathol Microbiol; 2002 Jan;45(1):115-7
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  • [Title] Mucinous carcinoma of rectosigmoid in a 15-year-old child: a case report.
  • A 15-year-old girl with Duke's B mucinous carcinoma of the rectosigmoid was treated with surgical resection and adjuvant chemotherapy.
  • Colorectal carcinoma is extremely rare in children and adolescents.
  • Adenocarcinoma of colon is a virulent disease in children and has a poor prognosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Colon, Sigmoid / pathology. Colorectal Neoplasms / pathology. Rectum / pathology

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  • (PMID = 12593578.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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2. Yang SW, Moon W: [A case of pseudomenbranous colitis after paclitaxel and carboplatin chemotherapy]. Korean J Gastroenterol; 2009 Nov;54(5):328-32
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  • [Title] [A case of pseudomenbranous colitis after paclitaxel and carboplatin chemotherapy].
  • Antibiotics-associated pseudomembranous colitis is well documented and caused by abnormal overgrowth of toxin producing Clostridium difficile colonizing the large bowel of patients undergoing antibiotic therapy.
  • We experienced a 67 old-years male patient diagnosed of non-small cell lung carcinoma who complained of watery diarrhea and abdominal pain after treated with paclitaxel and carboplatin.
  • Sigmoidoscopic examination revealed diffusely scattered, whitish to yellowish pseudomembrane with background edematous hyperemic mucosa from sigmoid colon to rectum.
  • The symptoms improved after stopping chemotherapy and treatment with metronidazole.
  • In patients with persistent diarrhea and abdominal pain after receiving chemotherapy agents, although rare, pseudomembranous colitis should be considered as a differential diagnosis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Carboplatin / adverse effects. Enterocolitis, Pseudomembranous / diagnosis. Paclitaxel / adverse effects
  • [MeSH-minor] Aged. Anti-Infective Agents / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Diagnosis, Differential. Humans. Lung Neoplasms / drug therapy. Male. Metronidazole / therapeutic use. Sigmoidoscopy. Tomography, X-Ray Computed

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  • (PMID = 19934614.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 140QMO216E / Metronidazole; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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3. Shin EK, Takizawa BT, Masters L, Shahabi S: The role of chemotherapy and prophylactic bilateral oophorectomy in a case of colorectal adenocarcinoma with ovarian metastases. Yale J Biol Med; 2001 Mar-Apr;74(2):101-5
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  • [Title] The role of chemotherapy and prophylactic bilateral oophorectomy in a case of colorectal adenocarcinoma with ovarian metastases.
  • On exploratory laparotomy, the mass was found to be a moderately differentiated adenocarcinoma of the sigmoid colon with metastasis to the left ovary.
  • A primary colorectal carcinoma that has metastasized to the ovaries can be difficult to distinguish clinically from an advanced primary ovarian tumor.
  • If the nature of the primary tumor is uncertain and the initial response to chemotherapy is poor, the patient's prognosis will also he poor.
  • Though controversy exists regarding the role of prophylactic bilateral oophorectomy during resection for primary colorectal cancer, later confusion can be avoided by performing this procedure when the colorectal carcinoma is first diagnosed.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Ovarian Neoplasms / secondary. Ovariectomy. Sigmoid Neoplasms / drug therapy. Sigmoid Neoplasms / surgery

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  • (PMID = 11393261.001).
  • [ISSN] 0044-0086
  • [Journal-full-title] The Yale journal of biology and medicine
  • [ISO-abbreviation] Yale J Biol Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2588692
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4. Gencosmanoglu R, Aker F, Kir G, Tozun N: Isolated metachronous splenic metastasis from synchronous colon cancer. World J Surg Oncol; 2006;4:42

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  • [Title] Isolated metachronous splenic metastasis from synchronous colon cancer.
  • BACKGROUND: Isolated splenic metastases from colorectal cancer are very rare and there are only 13 cases reported in the English literature so far.
  • CASE PRESENTATION: A 76-year-old man underwent an extended left hemicolectomy for synchronous colon cancers located at the left flexure and the sigmoid colon.
  • The tumors were staged as IIIC (T3N2M0) clinically and the patient received adjuvant chemotherapy.
  • However, a gradually rising CEA level after the 14th postoperative month necessitated further imaging studies including computed tomography of the abdomen which revealed a mass in the spleen that was subsequently confirmed by 18FDG- PET scanning to be an isolated metastasis.
  • The patient underwent splenectomy 17 months after his previous cancer surgery.
  • After an uneventful postoperative period, the patient has been symptom-free during the one-year of follow-up with normal blood CEA levels, although he did not accept to receive any further adjuvant therapy.
  • To the best of our knowledge, this 14th case of isolated splenic metastasis from colorectal carcinoma is also the first reported case of splenic metastasis demonstrated preoperatively by 18FDG PET-CT fusion scanning which revealed its solitary nature as well.
  • CONCLUSION: Isolated splenic metastasis is a rare finding in the follow-up of colorectal cancer patients and long-term survival can be achieved with splenectomy.

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  • (PMID = 16824207.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1526733
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5. Bhutani MS, Nadella P: Utility of an upper echoendoscope for endoscopic ultrasonography of malignant and benign conditions of the sigmoid/left colon and the rectum. Am J Gastroenterol; 2001 Dec;96(12):3318-22
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  • [Title] Utility of an upper echoendoscope for endoscopic ultrasonography of malignant and benign conditions of the sigmoid/left colon and the rectum.
  • OBJECTIVE: The majority of data on colonic endoscopic ultrasound (EUS) are limited to malignant lesions in the rectum and diseases of the anal sphincter.
  • The forward-oblique-viewing upper echoendoscope has been mostly applied for staging rectal cancer.
  • The purpose of our study was to evaluate the utility of a forward-oblique-viewing upper echoendoscope for EUS of malignant and benign lesions of the sigmoid/left colon and the rectum.
  • METHODS: Thirty-two EUS exams were performed for a variety of indications in the rectum and the sigmoid/left colon.
  • RESULTS: Twenty-six exams were done for staging of rectosigmoid carcinoma, follow-up after chemotherapy and/or radiation, or to look for recurrence after resection of colorectal cancer.
  • One patient subsequent to EUS imaging also underwent a linear EUS-guided fine-needle aspiration of a submucosal mass in the rectum with the fine-needle aspirate consistent with a myogenic tumor.
  • CONCLUSIONS: The forward-oblique-viewing upper echoendoscope is a versatile instrument that can be applied for EUS imaging of malignant and benign indications not only in the rectum but also in the sigmoid/left colon.
  • [MeSH-major] Colon / ultrasonography. Colonic Diseases / ultrasonography. Endoscopes / standards. Endosonography / instrumentation. Rectal Diseases / ultrasonography. Rectum / ultrasonography
  • [MeSH-minor] Colon, Sigmoid / ultrasonography. Colonic Neoplasms / ultrasonography. Humans. Neoplasm Staging / methods. Rectal Neoplasms / ultrasonography

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  • (PMID = 11774943.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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6. Jung SH, Kim HC, Yu CS, Chang HM, Ryu MH, Lee JL, Kim JS, Kim JC: [Clinicopathologic characteristics of colorectal neuroendocrine tumor]. Korean J Gastroenterol; 2006 Aug;48(2):97-103
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  • BACKGROUND/AIMS: Colorectal neuroendocrine carcinoma is a rare neoplasm exhibiting fulminant progression and having poor prognosis.
  • The purpose of this study is to verify the clinicopathologic characteristics of colorectal neuroendocrine carcinoma.
  • METHODS: From June 1997 to December 2004 at Asan Medical Center, ten patients were originally identified as colorectal neuroendocrine carcinoma on the basis of H&E and immunohistochemical staining (IHC).
  • RESULTS: Ten patients (0.2%) with colorectal neuroendocrine tumors were identified from 4,512 patients with colorectal cancer; ten neuroendocrine carcinomas and three adenocarcinomas with neuroendocrine differentiation.
  • Nine tumors were located in the rectum, two in the sigmoid, and each one in the transverse colon and cecum, respectively.
  • All patients were advanced at the time of diagnosis, with AJCC TNM staging: stage IIIB (n=2), stage IIIC (n=3), and stage IV (n=8).
  • Five patients who received chemotherapy showed median survival of 32 months (stage III) and 17.5 months (stage IV), whereas other five patients without chemotherapy died with a median survival of 6.2 months.
  • Nevertheless, improved survival may be achieved by aggressive multimodality therapy.
  • [MeSH-major] Carcinoma, Neuroendocrine / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biomarkers, Tumor / immunology. Biopsy. Chromogranin A / analysis. Chromogranin A / immunology. Drug Therapy, Combination. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Retrospective Studies. Sigmoid Neoplasms / drug therapy. Sigmoid Neoplasms / mortality. Sigmoid Neoplasms / pathology. Synaptophysin / analysis. Synaptophysin / immunology

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  • (PMID = 16929153.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Synaptophysin
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7. Tanoue Y, Tanaka N, Suzuki Y, Hata S, Yokota A: A case report of endocrine cell carcinoma in the sigmoid colon with inferior mesenteric vein tumor embolism. World J Gastroenterol; 2009 Jan 14;15(2):248-51
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  • [Title] A case report of endocrine cell carcinoma in the sigmoid colon with inferior mesenteric vein tumor embolism.
  • We report a case of endocrine cell carcinoma in the sigmoid colon with inferior mesenteric vein (IMV) tumor embolism.
  • We performed colonoscopy, computed tomography and positron emission tomography, which disclosed sigmoid colon cancer with IMV tumor embolism.
  • The tumor was diagnosed as endocrine cell carcinoma (type 4, pSS, med, INFalpha, v3, n1, stage IIIb).
  • She was treated with chemotherapy of cisplatin (CDDP) + irinotecan (CPT11).
  • This case highlights the aggressiveness of endocrine cell carcinoma with tumor embolism, and it is essential to establish an accurate diagnosis and effective treatment.

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  • (PMID = 19132778.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2653316
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8. Chintamani, Singhal V, Bansal A, Bhatnagar D, Saxena S: Isolated colostomy site recurrence in rectal cancer-two cases with review of literature. World J Surg Oncol; 2007;5:52
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  • [Title] Isolated colostomy site recurrence in rectal cancer-two cases with review of literature.
  • Various etiological factors like adenoma-cancer sequence, bile acids, recurrent and persistent physical damage at the colostomy site by faecal matter due to associated stomal stenosis have been considered responsible.
  • Both patients had received adjuvant chemotherapy following surgery.
  • CASE PRESENTATION: First case was a 30-year-old male that had reported with large bowel obstruction due to an obstructing ulcero-proliferative growth (poorly differentiated adenocarcinoma) at the colostomy site after abdomino-perineal resection, performed for low rectal cancer six years previously.
  • Second case was a 47-year-old male that presented with acute large bowel obstruction due to an annular growth (well differentiated adenocarcinoma) in the upper rectum.
  • He was managed by Hartmann's operation and the sigmoid colostomy was closed six months later.
  • Five years following closure of colostomy, he presented with two parietal masses at the previous colostomy site scar, which, on fine needle aspiration cytology were found to be well-differentiated adenocarcinomas of colorectal type.
  • CONCLUSIONS: Colostomy site/scar recurrence of rectal carcinoma is rare and could be due to various etiological factors, although the exact causative mechanism is not known.

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  • (PMID = 17567928.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 10
  • [Other-IDs] NLM/ PMC1876234
  • [General-notes] NLM/ Original DateCompleted: 20070730
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9. Lindel K, Willett CG, Shellito PC, Ott MJ, Clark J, Grossbard M, Ryan D, Ancukiewicz M: Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer. Radiother Oncol; 2001 Jan;58(1):83-7
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  • [Title] Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer.
  • BACKGROUND AND PURPOSE: To update and summarize the experience at the Massachusetts General Hospital of a treatment program of high-dose preoperative irradiation, surgical re-resection, and intraoperative radiation therapy (IORT) as a salvage treatment for patients with recurrent rectal or rectosigmoid carcinoma.
  • PATIENTS AND METHODS: From June 1978 to February 1997, the records of 69 patients with locally recurrent rectal carcinomas or rectosigmoid carcinomas without metastases referred for consideration of IORT were reviewed.
  • Chemotherapy had no significant influence on overall or disease-free survival.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Rectal Neoplasms / radiotherapy. Sigmoid Neoplasms / radiotherapy
  • [MeSH-minor] Antimetabolites, Antineoplastic / therapeutic use. Combined Modality Therapy. Disease-Free Survival. Dose-Response Relationship, Radiation. Fluorouracil / therapeutic use. Humans. Intraoperative Care. Neoplasm Staging. Preoperative Care. Salvage Therapy

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  • (PMID = 11165686.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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10. Luccichenti G, Cademartiri F, Sianesi M, Roncoroni L, Pavone P, Krestin GP: Radiologic assessment of rectosigmoid cancer before and after neoadjuvant radiation therapy: comparison between quantitation techniques. AJR Am J Roentgenol; 2005 Feb;184(2):526-30
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  • [Title] Radiologic assessment of rectosigmoid cancer before and after neoadjuvant radiation therapy: comparison between quantitation techniques.
  • OBJECTIVE: Volumetric analysis was compared with conventional unidimensional measurements for follow-up of rectosigmoid cancer before and after radiation therapy.
  • SUBJECTS AND METHODS: Fifteen patients with rectosigmoid cancer underwent helical CT before and after neoadjuvant radiation therapy.
  • The helical CT examination was performed after colon distention with air and IV administration of an antiperistaltic drug.
  • RESULTS: The mean of the differences between the volumetric analysis of the scans obtained before and after radiation therapy was 8.3 +/- 10.3 (SD) mL (-22.7%) (p <0.05).
  • The mean of the differences between the maximal wall thickness of the pre- and post-radiation therapy scans was 3.4 +/- 2.6 mm (-19.1%) (p <0.05).
  • A significant difference was observed between the variation of the maximal wall thickness and the variation of volumetric analysis in pre- and post-radiation therapy scans (p <0.05).
  • CONCLUSION: Volumetric analysis of rectosigmoid cancer is feasible.
  • [MeSH-major] Rectal Neoplasms / radiography. Rectal Neoplasms / radiotherapy. Sigmoid Neoplasms / radiography. Sigmoid Neoplasms / radiotherapy. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Female. Humans. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Male. Middle Aged. Neoadjuvant Therapy. Prospective Studies

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  • (PMID = 15671374.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Copur S, Ledakis P, Novinski D, Mleczko KL, Frankforter S, Bolton M, Fruehling RM, VanWie E, Norvell M, Muhvic J: Squamous cell carcinoma of the colon with an elevated serum squamous cell carcinoma antigen responding to combination chemotherapy. Clin Colorectal Cancer; 2001 May;1(1):55-8
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  • [Title] Squamous cell carcinoma of the colon with an elevated serum squamous cell carcinoma antigen responding to combination chemotherapy.
  • The most commonly reported anatomic locations are the rectum and the proximal colon.
  • Because of their extremely rare occurrence, it is difficult to study their natural course, clinical behavior, and response to therapy.
  • This report presents the case of a pure squamous cell colorectal cancer and provides a brief review of the literature, which includes 60 previously published cases.
  • The case of a patient with T3N2M0 primary squamous cell carcinoma of the rectosigmoid colon, which was initially treated with abdominoperineal resection followed by adjuvant chemotherapy and radiation, is presented.
  • During the follow-up, an elevated squamous cell carcinoma antigen (SCC Ag) level led to restaging computed tomography scans, which confirmed recurrent metastatic disease in the liver.
  • Response to chemotherapy with a decrease in tumor size correlated with a decrease in the serum SCC Ag level.
  • Although SCC Ag has been used as a tumor marker for squamous cell cancers of the lung, head and neck, uterine cervix, and esophagus, this is the first reported case of a squamous cell colon carcinoma presenting with an elevated SCC Ag at the time of recurrence.
  • In addition, this patient showed an objective partial response to combination chemotherapy, with a decrease in the serum level of this tumor marker.
  • [MeSH-major] Antigens, Neoplasm / blood. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Carcinoma, Squamous Cell / drug therapy. Colonic Neoplasms / drug therapy. Liver Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy. Serpins
  • [MeSH-minor] Cisplatin / administration & dosage. Etoposide / administration & dosage. Fatal Outcome. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 12445380.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Serpins; 0 / squamous cell carcinoma-related antigen; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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12. Polglase AL, McMurrick PJ, Tremayne AB, Bhathal PS: Local recurrence after curative anterior resection with principally blunt dissection for carcinoma of the rectum and rectosigmoid. Dis Colon Rectum; 2001 Jul;44(7):947-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Local recurrence after curative anterior resection with principally blunt dissection for carcinoma of the rectum and rectosigmoid.
  • PURPOSE: The aim of this study was to determine the incidence of local pelvic recurrence of carcinoma of the rectum and rectosigmoid (tumors where the lower edge is 18 cm or less from the anal verge) in a consecutive series of patients operated on by a single surgeon.
  • All patients underwent curative anterior resection and a formal anatomic dissection of the rectum where mobilization was achieved through a principally careful blunt manual technique along fascial planes, preserving an oncologic package.
  • METHOD: During the period April 1986 to December 1997, 157 consecutive anterior resections for carcinoma of the rectum and rectosigmoid were performed by one surgeon (ALP).
  • Local recurrences occurred between 16 and 38 months from the time of resection, and the cumulative risk of developing local recurrence at five years was 5.2 percent.
  • Local recurrence developed in 3 of 28 (10.7 percent) patients having ultralow anterior resection, 1 of 57 (1.8 percent) patients having low anterior resection (between 6 and 10 cm from the anal verge), and no patients having high anterior resection (above 10 cm from the anal verge).
  • The overall five-year cancer-specific survival rate of the entire group of 131 patients was 81.8 percent, and the overall probability of being disease free at five years including both local and distal recurrence was 72.9 percent.
  • Three local recurrences occurred in the 101 patients (77 percent) who did not receive any form of adjuvant therapy.
  • No recurrence occurred in the 12 patients (9.2 percent) who had adjuvant chemotherapy alone.
  • CONCLUSION: Curative anterior resection for carcinoma of the rectum and rectosigmoid with principally blunt dissection of the rectum in this study is associated with a 3.1 percent incidence and a 5.2 percent probability at five years of developing local recurrence.
  • [MeSH-major] Carcinoma / surgery. Digestive System Surgical Procedures / methods. Neoplasm Recurrence, Local. Rectal Neoplasms / surgery. Sigmoid Neoplasms / surgery
  • [MeSH-minor] Aged. Anastomosis, Surgical. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Time Factors. Treatment Outcome

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  • (PMID = 11496074.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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13. Suzuki R, Nakata K, Okamura S, Kanemura T, Yanai A, Kobayashi M, Yoshioka Y, Uji K, Yoshida A, Takeno A, Nakahira S, Miki H, Sugimoto K, Tamura S: [Case report--a long-term surviving patient who received lymph node dissection of skip metastasis from rectosigmoid cancer to bilateral lateral lymph nodes]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2598-600
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case report--a long-term surviving patient who received lymph node dissection of skip metastasis from rectosigmoid cancer to bilateral lateral lymph nodes].
  • Skip metastasis in colorectal cancer consists of about 10% of lymph node metastases.
  • A forty-two years old female received anterior resection for advanced rectosigmoid cancer.
  • Because pathological stage of the patient was stage IIIa (T3N1M0), standard adjuvant chemotherapy was provided.
  • [MeSH-minor] Adult. Carcinoembryonic Antigen / analysis. Chemotherapy, Adjuvant. Female. Humans

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  • (PMID = 21224651.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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14. Samareh Pahlavan P: The epidemiology, clinical findings and prognosis of colorectal cancer in Iran. J Clin Oncol; 2004 Jul 15;22(14_suppl):9630

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The epidemiology, clinical findings and prognosis of colorectal cancer in Iran.
  • : 9630 Background: This study was performed to evaluate the clinical features and outcome of patients with Colorectal cancer (CRC) in Iran.
  • METHODS: All cases of CRC presented to a main countryside referral University hospital (SGH) for cancers in Teheran, Iran between June 20,2000 and January 3,2003 were retrospectively reviewed to determine age, gender, subsite distribution, early symptoms, ethnicity, type of the CRC and the chemotherapy management.
  • RESULTS: A total of 200 patients were included .114 patients (57.0%) were male and 86 were female (43.0%) .Age ranged from 13-90 years with a mean of 55.15+/- 14.5 years.16.5% of patients were below 40 years of age.The tumors were classified as : appendix (n=4), cecum ( n=7), Right Cancers (RC), from the cecum to hepatic flexure (n=1), hepatic flexure ( n=2), Transverse Colon (n=19), Splenic Flexure (n=3), Left Colon (LC) from the Splenic Flexure down to Sigmoid (n=6), Sigmoid ( n=16), Rectum ( n=117), Rectosigmoid & Rectal lesions (n=16), and Colorectal lesions without known locations (n=9).
  • Non-Mucinous Adenocarcinoma was the most common (n=181, 90%), followed by Mucinous AC (n=15), SCC (n=1), Carcinoid (n=1), Melanoma (n=1), Signet ring carcinoma (n=1).
  • 37% of patients had anemia at the time of diagnosis.
  • 130 of patients underwent chemotherapy and the combination of 5-FU and Leucovorin was predominanat. (n=104, 52%) Younger patients significantly had more Mucinous AC (p=.008) and took more 5-FU.(p=0.05) Conclusions: We have no reports from the Epidemiology of CRC in Iran since 1977. the data suggested a younger age distribution for CRC .
  • we found no significant difference between age, gender and type of cancer with subsite distribution .
  • Distal (left-sided) CRC was more prevalent.
  • 30.5% of patients were diagnosed by screening studies which highly suggests the procedure.
  • Anemia was less common in our population. younger patients received medical attention and 5-FU medication earlier and more.

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  • (PMID = 28016212.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Toyooka M, Shoji Y: [A case of effective regimen of tegafur and uracil (UFT)/leucovorin (LV) plus irinotecan (CPT-11) for advanced rectal carcinoma with severe pelvic infiltration to be performed curative resection]. Gan To Kagaku Ryoho; 2007 Apr;34(4):635-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of effective regimen of tegafur and uracil (UFT)/leucovorin (LV) plus irinotecan (CPT-11) for advanced rectal carcinoma with severe pelvic infiltration to be performed curative resection].
  • Computed tomography, barium enema and colonoscopy revealed a cysto-rectal fistula and massive invasion to middle rectum and retroperitoneal space from the main tumor in the upper rectum.
  • Because of obstruction of passage of stool, sigmoid colostomy was performed.
  • Therefore, oral administration of UFT/LV+CPT-11 was considered as effective neoadjuvant chemotherapy for advanced rectal carcinoma, and this also could be a promising regimen to maintain the quality of life (QOL) for patients in ambulatory therapy.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / surgery. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Pelvic Neoplasms / pathology. Rectal Neoplasms / drug therapy. Rectal Neoplasms / surgery
  • [MeSH-minor] Administration, Oral. Aged. Ambulatory Care. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Chemotherapy, Adjuvant. Drug Administration Schedule. Drug Combinations. Humans. Leucovorin / administration & dosage. Male. Neoadjuvant Therapy. Neoplasm Invasiveness. Quality of Life. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 17431356.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / UFT(R) drug; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 7673326042 / irinotecan; Q573I9DVLP / Leucovorin; XT3Z54Z28A / Camptothecin
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16. Lincourt AE, Sing RF, Kercher KW, Stewart A, Demeter BL, Hope WW, Lang NP, Greene, Heniford BT: Association of demographic and treatment variables in long-term colon cancer survival. Surg Innov; 2008 Mar;15(1):17-25

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of demographic and treatment variables in long-term colon cancer survival.
  • The purpose of this study is to examine demographic and treatment variables because they relate to 5-year survival in colon cancer.
  • The study design is analysis of 174 471 patients with colon and rectosigmoid cancer as reported to the American College of Surgeons National Cancer Data Base.
  • Factors associated with a reduced risk of mortality included female gender (hazard ratio = 0.89; 95% confidence interval, 0.87-0.90), education status (hazard ratio = 0.87; 95% confidence interval, 0.85-0.89), increased number of lymph nodes resected (compared with <8, 8-12: hazard ratio = 0.90; 95% confidence interval, 0.89-0.92; >12: hazard ratio = 0.79; 95% confidence interval, 0.77-0.80), and addition of chemotherapy (hazard ratio = 0.69; 95% CI, 0.68-0.71).
  • Survival in colon cancer is significantly impacted by patient's age, race, gender, and education status but not by income or area of residence.
  • [MeSH-major] Colonic Neoplasms / therapy. Demography. Rectal Neoplasms / therapy. Sigmoid Neoplasms / therapy
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Sex Factors. Survival Rate. Time Factors

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  • (PMID = 18388001.001).
  • [ISSN] 1553-3506
  • [Journal-full-title] Surgical innovation
  • [ISO-abbreviation] Surg Innov
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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17. Kecmanović D, Kovacević P, Pavlov M, Sepetkovski A, Ceranić M: [Cytoreductive procedures in advanced primary ovarian carcinoma]. Acta Chir Iugosl; 2001;48(1):71-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cytoreductive procedures in advanced primary ovarian carcinoma].
  • Explorative curretage of uterus--PH findings: malignant tissue.
  • Irigography: spasticity and extraluminal compression to proximal third of rectum and distal sigmoid colon.
  • Intraoperative findings confirmed malignant deposits on the right colon serosa, so we performed right hemicolectomy with ileo-colo anastomosis, omentectomy, hysterectomy, bilateral adnexectomy, low anterior resection of the rectum, peritonectomy of pelvis and reconstruction of digestive tubus by colo-rectal anastomosis with circular stapler ILS 33.
  • One month after the operation, systemic chemotherapy consisting of Endoxan and Karboblastin was administered, for the duration of 6 months, once monthly.
  • [MeSH-major] Carcinoma / secondary. Carcinoma / surgery. Ovarian Neoplasms / surgery

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  • (PMID = 11432258.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] hrv
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Yugoslavia
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18. Aoyagi H, Kaneko J, Ono H, Isogai J, Yoshida M, Someno Y, Katsuta E, Saguchi M, Takahata T, Hasegawa K, Hamada S, Higuchi T, Sugihara K, Maejima S: [A case of unresectable and multiple advanced primary cancers of the stomach and rectosigmoid colon with hepatic metastases successfully treated with FOLFIRI for local control of a gastric lesion]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2433-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of unresectable and multiple advanced primary cancers of the stomach and rectosigmoid colon with hepatic metastases successfully treated with FOLFIRI for local control of a gastric lesion].
  • Contrast enhanced abdominal CT showed a rectosigmoid tumor invading the left pelvic wall and multiple metastatic hepatic tumors.
  • Colonoscopy showed a type-2 cancer in the rectosigmoid region.
  • The patient underwent sigmoid colostomy 3 days after admission.
  • Postoperative upper gastrointestinal endoscopy showed a type 3 cancer in the fornix.
  • From the above findings, the patient was diagnosed with unresectable gastric and rectosigmoid cancers with multiple hepatic metastases, and systemic chemotherapy was initiated.
  • The first line treatment was two courses of S-1, but it was discontinued due to PD.
  • FOLFIRI was begun as the second line treatment.
  • Twelve courses of FOLFIRI chemotherapy were performed in total.
  • However, the gastric lesion had been controlled well after the second line treatment.
  • The findings of the present study suggested that FOLFIRI could be an effective treatment for unresectable multiple advanced cancers of the stomach and colorectal cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Liver Neoplasms / secondary. Neoplasms, Multiple Primary / therapy. Sigmoid Neoplasms / pathology. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Camptothecin / analogs & derivatives. Camptothecin / therapeutic use. Fluorouracil / therapeutic use. Humans. Leucovorin / therapeutic use. Male. Middle Aged

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  • (PMID = 21224597.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; IFL protocol
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19. Abraham NS, Gossey JT, Davila JA, Al-Oudat S, Kramer JK: Receipt of recommended therapy by patients with advanced colorectal cancer. Am J Gastroenterol; 2006 Jun;101(6):1320-8
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Receipt of recommended therapy by patients with advanced colorectal cancer.
  • OBJECTIVES: To evaluate utilization of surgery, chemotherapy, and radiation therapy among patients with stage II or III colon cancer and stage II/III rectal or rectosigmoid cancer, as recommended by current national guidelines.
  • DeBakey Veterans Affairs Medical Center (Houston, TX) used 1999-2003 administrative data to identify patients with a diagnostic code for colorectal cancer.
  • Medical charts were then abstracted to identify an incident cohort with stage II or III cancer.
  • Outcome of interest was receipt of recommended therapy defined as surgery only (stage II colon) or surgery with adjuvant chemo- or radiotherapy (stage III colon or stage II/III rectal/rectosigmoid cancer).
  • Potential determinants of receipt of recommended therapy were analyzed using logistic regression.
  • A gastroenterologist diagnosed 72.5% tumors including 62 stage II colon, 62 stage III colon, and 73 stage II/III rectal cancers.
  • Referral to oncology occurred in 76% of stage II colon, 92% of stage III colon, and 99% of rectal cancers.
  • 87% of stage II and 71% of stage III colon cancer patients received recommended therapy, compared to only 42.5% of rectal cancer patients.
  • Predictors of receipt of recommended therapy among rectal cancers included being married (OR, 5.3; 95% CI: 1.6-17.1), presentation at tumor board (OR, 3.6; 95% CI: 1.2-11.2), or age<65 yr (OR, 3.5; 95% CI: 1.3-9.3).
  • When patient's comorbidity and physician's decision-making process were considered in the assessment of the outcome, only presentation at tumor board remained predictive of receipt of recommended therapy.
  • CONCLUSIONS: Most colon cancer patients at a major VA medical center receive recommended therapy.
  • Among rectal cancer patients, those presented at tumor board are most likely to receive recommended therapy.
  • [MeSH-major] Colorectal Neoplasms / therapy. Patient Acceptance of Health Care

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  • (PMID = 16771956.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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20. Liang JT, Lai HS, Lee PH: Laparoscopic medial-to-lateral approach for the curative resection of right-sided colon cancer. Ann Surg Oncol; 2007 Jun;14(6):1878-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Laparoscopic medial-to-lateral approach for the curative resection of right-sided colon cancer.
  • INTRODUCTION: Our previous randomized clinical trial comparing the laparoscopic medial-to-lateral dissection with the more classic lateral-to-medial approach for resection of rectosigmoid cancer showed that the medial approach reduces the operative time and the postoperative proinflammatory response.
  • Besides the oncologic advantages of an early vessel division and a "no-touch" dissection, we feel that the longer the lateral abdominal wall attachments of the colon are preserved, the better the exposure and the easier the dissection.
  • Encouraged by the above-mentioned positive findings, we therefore further conduct this phase II clinical trial to examine the feasibility and surgical outcomes regarding the utilization of this medial-to-lateral laparoscopic dissection approach for the curative resection of right-sided colon cancer.
  • METHODS: A total of 104 patients (from December 2000 to January, 2005) with advanced right-sided colon cancer (TNM stage II: n = 56; stage III: n = 48) requiring a curative right hemicolectomy were subjected to the laparoscopic medial-to-lateral approach that included initial exploration and ligation of ileocolic, right colic, and middle colic vessels in no-touch isolation fashion, subsequent medial-to-lateral extension of retroperitoneal dissection along Gerota fascia, opening of lesser sac by transection of gastrocolic ligament, and the final mobilization of hepatic flexure and lateral attachments of ascending colon (Fig. 1).
  • Postoperatively, adjuvant chemotherapy with Mayo Clinic Regimen was given in patients with stage III diseases.
  • RESULTS: The laparoscopic medial-to-lateral approach for a curative right hemicolectomy can be preformed with acceptable operation time (192.6 +/- 32.8 min, mean +/- standard deviation) and little blood loss (48.4 +/- 14.4 ml) through a small wound (6.0 +/- 0.8 cm).
  • During the follow-up periods (median: 30 months, range 6-55 months), recurrence of tumor developed in 6 (10.7%) of stage II and 10 (20.8%) of stage III patients, with liver metastasis in six patients, lung metastasis in 4, liver and lung metastasis in 1, intraperitoneal recurrence in 2, bone metastasis in 1, brain metastasis in 1, and port-site recurrence in 1.
  • [MeSH-major] Colectomy / methods. Colon, Ascending / surgery. Colonic Neoplasms / surgery. Laparoscopy / methods
  • [MeSH-minor] Blood Loss, Surgical. Chemotherapy, Adjuvant. Dissection / methods. Feasibility Studies. Follow-Up Studies. Hospitalization. Humans. Ileus / etiology. Ligaments / surgery. Ligation. Neoplasm Metastasis. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Pain, Postoperative / etiology. Postoperative Complications. Prospective Studies. Recovery of Function / physiology. Time Factors. Treatment Outcome

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  • (PMID = 17377832.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article
  • [Publication-country] United States
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21. Fleckenstein GH, Gunawan B, Brinck U, Wuttke W, Emons G: Simultaneous sertoli cell tumor and adenocarcinoma of the tunica vaginalis testis in a patient with testicular feminization. Gynecol Oncol; 2002 Mar;84(3):460-3
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  • Histologically, we found a well-differentiated Sertoli cell tumor and an adenocarcinoma of the tunica vaginalis testis with metastases in the sigmoid colon, rectum, and omentum.
  • After debulking surgery to optimal residual disease and four courses of chemotherapy (cisplatin and etoposide), there was no evidence of disease (clinically) for 24 months before an intraabdominal and inguinal relapse occurred.
  • Due to the unwillingness of the patient to receive salvage chemotherapy or palliative abdominal surgery, the disease progressed rapidly and she died 27 months after the initial operation.
  • CONCLUSION: This is the first reported case of an advanced carcinoma of the tunica vaginalis testis occurring simultaneously with a large Sertoli cell tumor in a patient with testicular feminization.
  • Surgical debulking and platinum-based chemotherapy rendered the patient clinically free of disease for 2 years.

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  • (PMID = 11855889.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Law WL, Chu KW: Outcomes of resection of stage IV rectal cancer with mesorectal excision. J Surg Oncol; 2006 Jun 1;93(7):523-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes of resection of stage IV rectal cancer with mesorectal excision.
  • BACKGROUND: There is no consensus as to the management of the primary rectal cancer in the presence of distant metastasis and data on the outcomes of radical resection in stage IV rectal cancer are limited.
  • This study aims to evaluate the results of resection of rectal cancer in the patients with stage IV disease and to analyze the factors that might affect the survival of these patients.
  • METHODS: Of the 744 patients with radical resection of primary rectal and rectosigmoid cancer during the study period from August 1993 to July 2002, 70 had stage IV disease on the initial presentation.
  • The median cancer-specific survival of the patients who survived the surgery was 15.2 months.
  • Multivariate analysis showed that the presence of gross residual local disease, lymph node metastasis, liver involvement of over 50%, the absence of surgical management of liver metastasis and those without chemotherapy were independent factors associated with poor survival.
  • CONCLUSIONS: Postoperative mortality and morbidity were acceptable in patients with stage IV rectal cancer.
  • Surgical management of the metastasis and the administration of chemotherapy are associated with better survival.
  • However, the optional treatment regimes are yet to be defined.
  • [MeSH-major] Lymph Nodes / pathology. Neoplasm Recurrence, Local / surgery. Rectal Neoplasms / surgery. Rectum / surgery. Sigmoid Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Liver Neoplasms / secondary. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Peritoneal Neoplasms / secondary. Survival Rate. Treatment Outcome

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16705728.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Capretti PG, Zeppieri MC, Simonetti A, Rosato S, Lovotti D, Battaini A, Capretti G, Agnes Pradelli B: [Radical peritonectomy in 37 patients with stage II and III ovarian cancer]. Minerva Chir; 2004 Jun;59(3):233-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Radical peritonectomy in 37 patients with stage II and III ovarian cancer].
  • AIM: Radical peritonectomy followed by intraperitoneal early chemotherapy and systemic chemotherapy is the treatment of choice of stage II C and III ovarian cancer, due to the low 5-years survival rate (20%) of stage III and IV.
  • METHODS: The authors present a 5-years experience in 37 patients affected by stage II C and III ovarian cancer treated by Sugarbaker's radical peritonectomy with some surgical technical differences.
  • Intraperitoneal chemotherapy with adriamycin and cisplatin is started and followed after 25 days by a systemic chemotherapy with taxol and carboplatin.
  • RESULTS: All the patients have been treated with radical peritonectomy with tumoral residual lesser than 2.5 mm; we performed 4 minor hepatectomies, 5 radical cystectomies, 35 resections of rectum and sigmoid colon with hysterectomies, bilateral salpingo-oophorectomies and pelviperitonectomies, 14 right hemicolectomies.
  • CONCLUSION: Radical surgery associated with early postoperative chemotherapy followed by systemic chemotherapy in the treatment of ovarian cancer makes it possible to achieve the best survival results and long periods of disease free.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma / pathology. Carcinoma / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Peritoneum / surgery
  • [MeSH-minor] Carboplatin / administration & dosage. Chemotherapy, Adjuvant / methods. Cisplatin / administration & dosage. Doxorubicin / administration & dosage. Female. Humans. Infusions, Parenteral. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Paclitaxel / administration & dosage. Retrospective Studies. Second-Look Surgery. Treatment Outcome

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  • (PMID = 15252388.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 80168379AG / Doxorubicin; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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24. Nair V, Rattan KN, Kaushal V, Atri R, Dhankar R, Kaur P, Kadian J: Non-familial paediatric colorectal cancers--an 18 years' experience. Trop Gastroenterol; 2009 Jan-Mar;30(1):51-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: The aim of this study was to describe our 18 years' experience with non-familial paediatric colorectal malignancies, outlining pertinent features of diagnosis, treatment and outcome.
  • After the initial surgical management, the advanced cases underwent chemotherapy and radiation therapy where required and were followed up.
  • Three tumours arose in the rectum, three in the sigmoid colon, one each in the splenic flexure and appendix, and there was one case of diffuse colonic polyposis.
  • Two cases of sigmoid carcinoma were unresectable and expired 4 months post-surgery.
  • Three patients required palliative radiation therapy.
  • Due to the advanced stage, chemotherapy was given to all the carcinoma patients.
  • One patient had local recurrence after 5 months and another developed distant metastasis.
  • Advanced stages may also require chemotherapy and radiation therapy.
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / therapy
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols. Child. Colon / pathology. Colon / surgery. Combined Modality Therapy. Female. Humans. India. Male. Palliative Care / methods. Rectum / pathology. Rectum / surgery. Treatment Outcome

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  • (PMID = 19624092.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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25. De Santis M, Ariosi P, Calò GF, Luppi G, Franchini M, Romagnoli R: [Antineoplastic perfusion with percutaneous stop-flow control in the treatment of advanced pelvic malignant neoplasms]. Radiol Med; 2000 Jul-Aug;100(1-2):56-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Antineoplastic perfusion with percutaneous stop-flow control in the treatment of advanced pelvic malignant neoplasms].
  • [Transliterated title] Perfusione antiblastica con controllo del flusso per via percutanea nel trattamento delle neoplasie maligne pelviche avanzate.
  • PURPOSE: The object of our study was to apply percutaneous stop-flow technique to advanced pelvic cancer in order to evaluate its feasibility, standardize the procedure and obtain preliminary results.
  • MATERIAL AND METHODS: April to December 1997 we submitted ten patients with advanced pelvic cancer to percutaneous stop-flow technique.
  • Seven patients had a pelvic recurrence from carcinoma of the rectum, two patients had inoperable recto-sigmoid cancer, and another one had a local recurrence of ovarian cancer.
  • All treatments were performed under general anesthesia.
  • Blood flow was interrupted for a maximum of 20 min to limit tissue damage, especially of the anal sphincter.
  • Morphological response was evaluated by CT or MR scan performed prior to and 40 days after the treatment.
  • Death followed tumor progression in 6 cases; one patient died during the procedure and another one after 7 days, both secondary to pulmonary embolism.
  • Complications included intra-arterial rupture of the balloon in one case and a large inguinal hematoma 10 days after the treatment, requiring hospitalization.
  • CONCLUSIONS: This trial supports the feasibility of using the percutaneous stop-flow procedure in an angiography room setting; the stop-flow technique failed to permit the effective control of the tumors.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Chemotherapy, Cancer, Regional Perfusion / methods. Neoplasm Recurrence, Local / drug therapy. Pelvic Neoplasms / drug therapy
  • [MeSH-minor] Aged. Anesthesia, General. Antibiotics, Antineoplastic / administration & dosage. Aorta, Abdominal / radiography. Cisplatin / administration & dosage. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Mitomycin / administration & dosage. Pelvis / pathology. Pelvis / radiography. Tomography, X-Ray Computed

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  • (PMID = 11109453.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] ITALY
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin
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26. Chen CQ, Fang LK, Ma JP, Cai SR, Dong WG, Huang YH, He YL, Zhan WH: [Regression analysis of the characteristics and outcome of colorectal cancer 1995 - 2007]. Zhonghua Yi Xue Za Zhi; 2010 Jul 13;90(26):1804-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Regression analysis of the characteristics and outcome of colorectal cancer 1995 - 2007].
  • OBJECTIVE: To explore the clinical characteristics and the prognostic factors of patients with colorectal cancer.
  • METHODS: The data of 2042 cases of colorectal cancer, pathologically confirmed at our hospital from January 1995 to December 2007, were summarized and analyzed.
  • RESULTS: The median age of all cases with colorectal cancer was 59 years old.
  • The lesions located in rectum accounted for 46.2% and those for 22.0% in sigmoid.
  • Patients under age 40 had a higher percentage of poor differentiation (33.5%) and mucinous carcinoma (16.7%).
  • The independent risk factors for patient prognosis were age, gross type, differentiation, TNM staging and surgical type.
  • Adjuvant chemotherapy was a protective factor.
  • As compared with phase I (1995 - 2001), phase II (2002 - 2007) had a higher proportions of employing stapler, Dixon operation and adjuvant chemotherapy.
  • CONCLUSION: The prognostic factors of patients with colorectal cancer are age, gross type, differentiation, TNM staging, surgical type and adjuvant chemotherapy.

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  • (PMID = 20979822.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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27. Yumuk PF, Abacioglu U, Caglar H, Gumus M, Sengoz M, Turhal NS: Outcome of rectal and sigmoid carcinoma patients receiving adjuvant chemoradiotherapy in Marmara University Hospital. J Chemother; 2003 Dec;15(6):603-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome of rectal and sigmoid carcinoma patients receiving adjuvant chemoradiotherapy in Marmara University Hospital.
  • Adjuvant chemoradiotherapy is the standard treatment in resected stage II/III rectosigmoid carcinoma.
  • Radiotherapy was started at 7th week and 45-50.4 Gy was given to pelvic region.
  • Protracted short-term infusion of 5-fluorouracil during pelvic irradiation is a safe treatment modality.
  • Further studies are needed to improve the local control of high-risk rectal and sigmoid carcinomas.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / radiotherapy. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy. Sigmoid Neoplasms / drug therapy. Sigmoid Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Colectomy / methods. Combined Modality Therapy. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Follow-Up Studies. Hospitals, University. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Survival Analysis. Turkey

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  • (PMID = 14998088.001).
  • [ISSN] 1120-009X
  • [Journal-full-title] Journal of chemotherapy (Florence, Italy)
  • [ISO-abbreviation] J Chemother
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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28. Pahlavan PS, Kanthan R: The epidemiology and clinical findings of colorectal cancer in Iran. J Gastrointestin Liver Dis; 2006 Mar;15(1):15-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The epidemiology and clinical findings of colorectal cancer in Iran.
  • BACKGROUND: This study was performed to evaluate the prevalence, clinical features and management of patients with colorectal cancer (CRC) in Iran.
  • The tumors were categorized according to their distribution as appendix (n=4), cecum ( n=7), right colon (n=1), hepatic flexure (n=2), transverse colon (n=19), splenic flexure (n=3), left colon (n=6), sigmoid ( n=16), rectum (n=117), rectosigmoid and rectal lesions (n=16), and colorectal lesions without known locations (n=9).
  • Non-mucinous adenocarcinoma (AC) was the most common histological type (n=181, 90%), followed by mucinous AC (n=15), squamous cell carcinoma (n=1), carcinoid (n=1), melanoma (n=1) and signet ring carcinoma (n=1).
  • Younger patients had a greater preponderance of mucinous AC (p=0.008) and generally underwent more extensive chemotherapy as seen with more usage of 5-Fluorouracil (p=0.05).
  • We found no significant difference between age, gender and type of cancer with subsite distribution.
  • Distal CRC was more prevalent.

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  • (PMID = 16680227.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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29. Nguyen KT, Laurent A, Dagher I, Geller DA, Steel J, Thomas MT, Marvin M, Ravindra KV, Mejia A, Lainas P, Franco D, Cherqui D, Buell JF, Gamblin TC: Minimally invasive liver resection for metastatic colorectal cancer: a multi-institutional, international report of safety, feasibility, and early outcomes. Ann Surg; 2009 Nov;250(5):842-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive liver resection for metastatic colorectal cancer: a multi-institutional, international report of safety, feasibility, and early outcomes.
  • OBJECTIVE: To evaluate a multicenter, international series on minimally invasive liver resection for colorectal carcinoma (CRC) metastasis.
  • The most common sites of primary colon cancer were sigmoid/rectum (51%), right colon (25%), and left colon (13%).
  • For those with metachronous lesions liver lesions, the median time interval from primary colon cancer surgery to liver metastasectomy was 12 months.
  • Preoperative chemotherapy was administered in 68% of cases prior to liver resection.
  • Median OR time was 234 minutes (range, 60-555 minutes) and blood loss was 200 mL (range, 20-2500 mL) with 10% receiving a blood transfusion.






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