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Items 1 to 19 of about 19
1. Vaamonde P, Martín Martín C, del Río Valeiras M, Labella Caballero T: [A study of cervical metastases from unknown primary tumor]. Acta Otorrinolaringol Esp; 2002 Oct;53(8):601-6
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  • Cervical metastases of cancer of an unknown primary tumour (CMUPT) are infrequent but they represent botha diagnostic and therapeutic challenge for ENT physicians.
  • 73% were squamous cell carcinoma and 27% were undifferentiated carcinoma.
  • We established our protocol on diagnosis and management: panendoscopy with biopsies of nasopharynx, vallecula and pyriform sinus and ipsilateral tonsillectomy.
  • All squamous cell carcinoma were treated with radical neck surgery plus radiotherapy and the undifferentiated carcinoma with chemotherapy and radiotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / secondary. Neoplasms, Unknown Primary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 12530200.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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2. Qureshi SS, Chaturvedi P, Pai PS, Chaukar DA, Deshpande MS, Pathak KA, D'cruz AK: A prospective study of pharyngocutaneous fistulas following total laryngectomy. J Cancer Res Ther; 2005 Jan-Mar;1(1):51-6
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  • It leads to increased morbidity, delay in adjuvant treatment, prolonged hospitalization and an increase in treatment costs.
  • We undertook a prospective study to critically analyze PC fistula and its association with various tumors, patient and treatment related factors.
  • This was a prospective study that included 143 patients who underwent laryngeal surgery for squamous cell carcinoma of the larynx and pyriform sinus.
  • Use of pectoralis major myocutaneous flap to reconstruct the neopharynx, primary disease in pyriform and extensive soft tissue infiltration were significantly associated with PC fistula.
  • Prior treatment (radiotherapy and chemotherapy), type of closure (T closure, Y closure and vertical closure), Layers of closure (full thickness interrupted, submucosal interrupted, submucosal continuous) type of suture material (silk, vicryl ), age, sex, stage, preoperative tracheostomy, cut margin status, pre/postoperative hemoglobin and experience of surgeons did not relate significantly.

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  • (PMID = 17998627.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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3. Prades JM, Schmitt TM, Timoshenko AP, Simon PG, de Cornulier J, Durand M, Guillot A, Martin C: Concomitant chemoradiotherapy in pyriform sinus carcinoma. Arch Otolaryngol Head Neck Surg; 2002 Apr;128(4):384-8
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  • [Title] Concomitant chemoradiotherapy in pyriform sinus carcinoma.
  • OBJECTIVES: To test the effectiveness of concurrent chemoradiotherapy in patients with pyriform sinus carcinoma and to demonstrate the feasibility of an organ preservation approach.
  • PATIENTS: The study population comprised 46 male patients with resectable stage III and IV pyriform sinus carcinoma.
  • In protocol 1 (24 patients), carboplatin was given on days 1 through 5 and 28 through 33, with an area under the curve dose of 5 mg/mL for 1 minute per day and bifractionated radiotherapy (160 rad [1.6 Gy]/fraction) delivered on days 1 through 16 and 28 through 38.
  • A treatment break was planned on days 16 through 27.
  • In protocol 2 (22 patients), chemotherapy was given with the same dose of carboplatin on days 1 and 21, and fluorouracil (750 mg/m(2) per day) on days 1 through 7 and 21 through 28.
  • Radiotherapy with a single fraction of 180 rad (1.8 Gy)/d was delivered during the first 2 weeks and then 150 rad (1.5 Gy) twice a day during the next 3 weeks.
  • During therapy, 15 patients (63%) (protocol 1) and 19 patients (86%) (protocol 2) required unplanned hospitalization for toxic effects.
  • CONCLUSION: Concomitant chemotherapy and bifractionated radiotherapy, although toxic, leads to good locoregional control and therefore to a significant level of laryngeal preservation.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / therapeutic use. Combined Modality Therapy / adverse effects. Disease-Free Survival. Dose Fractionation. Fluorouracil / therapeutic use. Humans. Larynx. Male. Middle Aged. Survival Rate

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  • [CommentIn] Arch Otolaryngol Head Neck Surg. 2003 Dec;129(12):1351; author reply 1351 [14676171.001]
  • (PMID = 11926911.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; U3P01618RT / Fluorouracil
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4. León X, Quer M, Orús C, Morán J, Recher K: Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced pyriform sinus carcinoma. Eur Arch Otorhinolaryngol; 2002 Jan;259(1):32-6
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  • [Title] Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced pyriform sinus carcinoma.
  • An alternative to the classical treatment for locally advanced (T3-T4 stage) pyriform sinus carcinoma with surgery and postoperative radiotherapy is to begin treatment with induction chemotherapy in an organ preservation approach.
  • In patients with complete clinical response, this treatment is followed by radiotherapy; in noncomplete responders, it is followed by surgery and postoperative radiotherapy.
  • We conducted a retrospective study to evaluate such treatment in a cohort of 78 patients with locally advanced pyriform sinus carcinoma treated at a single institution between 1985 and 1997.
  • In all patients, induction chemotherapy with cisplatin and 5-fluoruracil was carried out.
  • Two patients died as a consequence of complications associated with chemotherapy treatment.
  • Of the 76 patients who completed treatment, 23 (30%) achieved a complete response at the primary site, 38 (50%) attained a partial response, and 15 patients (20%) had a stabilization-progression.
  • There were no significant differences in survival related to the subsequent treatment used (P > 0.05).
  • The larynx was preserved in 14 of the 23 patients (61%) who completed treatment with induction chemotherapy and radiotherapy.
  • The frequency of organ preservation for the group of 78 patients who began treatment with induction chemotherapy was 18%.
  • [MeSH-major] Laryngeal Neoplasms / drug therapy. Laryngeal Neoplasms / radiotherapy
  • [MeSH-minor] Cisplatin / therapeutic use. Combined Modality Therapy. Fluorouracil / therapeutic use. Humans. Neoplasm Recurrence, Local. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 11954923.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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5. Holsinger FC, Motamed M, Garcia D, Brasnu D, Ménard M, Laccourreye O: Resection of selected invasive squamous cell carcinoma of the pyriform sinus by means of the lateral pharyngotomy approach: the partial lateral pharyngectomy. Head Neck; 2006 Aug;28(8):705-11
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  • [Title] Resection of selected invasive squamous cell carcinoma of the pyriform sinus by means of the lateral pharyngotomy approach: the partial lateral pharyngectomy.
  • BACKGROUND: Although the lateral pharyngotomy is a well-known surgical procedure, to our knowledge, no published reports have described the results achieved with a lateral pharyngectomy approach in patients with isolated and previously untreated selected invasive squamous cell carcinoma of the lateral wall of the pyriform sinus.
  • METHODS: The medical files and operative charts of 30 patients with an isolated, and previously untreated, squamous cell carcinoma of the pyriform sinus, treated for cure by lateral partial pharyngectomy and primary closure, as well as postoperative radiotherapy (n = 22), and preoperative chemotherapy (n = 8), were retrospectively studied.
  • The use of a platin-based induction chemotherapy (p = .05) regimen was the only variable that was significantly statistically related to local recurrence.
  • CONCLUSION: Partial pharyngectomy by means of the lateral pharyngotomy combined with postoperative radiation therapy is an efficient and function-sparing approach to control selected invasive squamous cell carcinomas of the lateral wall of the pyriform sinus.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Pharyngeal Neoplasms / surgery. Pharyngectomy. Pharynx / surgery

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  • (PMID = 16786602.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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6. Prades JM, Lallemant B, Garrel R, Reyt E, Righini C, Schmitt T, Remini N, Saban-Roche L, Timoshenko AP, Trombert B, Guerrier B: Randomized phase III trial comparing induction chemotherapy followed by radiotherapy to concomitant chemoradiotherapy for laryngeal preservation in T3M0 pyriform sinus carcinoma. Acta Otolaryngol; 2010;130(1):150-5
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  • [Title] Randomized phase III trial comparing induction chemotherapy followed by radiotherapy to concomitant chemoradiotherapy for laryngeal preservation in T3M0 pyriform sinus carcinoma.
  • CONCLUSIONS: Conventional radiotherapy with concurrent cisplatin is significantly superior to induction cisplatin fluorouracil chemotherapy followed by radiotherapy in terms of laryngeal preservation in patients with T3 hypopharyngeal carcinoma.
  • OBJECTIVES: To compare conventional radiotherapy with concurrent cisplatin to induction chemotherapy with cisplatin fluorouracil followed by conventional radiotherapy.
  • PATIENTS AND METHODS: Seventy-one adult patients with previously untreated resectable T3 pyriform sinus squamous cell carcinoma were enrolled in the multicenter prospective randomized phase III trial.
  • RESULTS: The rates of laryngeal preservation at 2 years were 68% for the induction chemotherapy (IC) group and 92% for the chemoradiotherapy (CR) group (p = 0.016).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Cisplatin / administration & dosage. Fluorouracil / administration & dosage. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / radiotherapy. Neoadjuvant Therapy. Pyriform Sinus
  • [MeSH-minor] Cause of Death. Combined Modality Therapy. Disease-Free Survival. Humans. Laryngectomy. Neoplasm Staging. Prognosis. Prospective Studies

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  • (PMID = 19449227.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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7. Hinerman RW, Amdur RJ, Mendenhall WM, Villaret DB, Robbins KT: Hypopharyngeal carcinoma. Curr Treat Options Oncol; 2002 Feb;3(1):41-9
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  • [Title] Hypopharyngeal carcinoma.
  • For more than 20 years, the policy at the University of Florida has been to treat patients with favorable stage T1-T2 pyriform sinus carcinoma by using radiation therapy alone, or with a planned neck dissection if advanced nodal disease is present.
  • Recent data have shown that adjuvant chemotherapy administered concomitantly with radiotherapy results in improved cure rates for patients with advanced disease compared with irradiation alone.
  • Time-honored established guidelines are still used, although the edges have become blurred.
  • Therefore, patients with larger primary tumors now may be considered for organ preservation treatment with irradiation and chemotherapy, reserving surgery for salvage situations.
  • The subset of patients with advanced T4 pyriform sinus cancers (in whom cure with chemoradiation would likely result in tracheostomy and/or gastrostomy dependence) may be better served with elective surgery and postoperative irradiation.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Hypopharyngeal Neoplasms / therapy
  • [MeSH-minor] Chemotherapy, Adjuvant / methods. Health Behavior. Humans. Otorhinolaryngologic Surgical Procedures. Radiotherapy / adverse effects. Radiotherapy / methods. Substance-Related Disorders / complications. Survival Analysis

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  • (PMID = 12057086.001).
  • [ISSN] 1527-2729
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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8. Zimmer-Nowicka J, Kaczmarczyk D, Chudobiński C, Kubiak R, Niedźwiecka I, Morawiec-Bajda A: [Diagnostic problems in a case of the pyriform sinus carcinoma in a man]. Otolaryngol Pol; 2008;62(4):442-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic problems in a case of the pyriform sinus carcinoma in a man].
  • Despite a use of many diagnostic tools to assess the stage of the carcinoma of hypopharynx and larynx various problems can still arise.
  • A 45 years old man was admitted with an initial diagnosis of carcinoma of the hypopharynx with metastases to neck lymphnodes (Tin situ N1).
  • Computed tomography of the neck revealed pathologic remodeling of the thyroid cartilage.
  • An oncologist decided to commence a chemotherapy.
  • After 4 cycles of chemotherapy a second CT scan revealed a suspected neoplastic infiltration of the cricoid and thyroid cartilages.
  • After that the patients was disqualified from both radio- and chemotherapy.
  • The second specimen taken from the right pyriform sinus was a loosen fragment of the epithelium with the Ca male differentiatum G3.
  • The positron emission tomography imaging found a suspected site 11 mm in diameter situated in front of the carotid vessels.
  • Another cause of the diagnostic problems could stem form an unfinished calcification of the cartilages which produced an image of irregular areas of calcification and rarely diagnosed T in situ in a pyriform sinus.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiography. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / radiography. Hypopharynx / pathology. Hypopharynx / radiography
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed / methods

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  • (PMID = 18837220.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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9. Amdur RJ, Mendenhall WM, Stringer SP, Villaret DB, Cassisi NJ: Organ preservation with radiotherapy for T1-T2 carcinoma of the pyriform sinus. Head Neck; 2001 May;23(5):353-62
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  • [Title] Organ preservation with radiotherapy for T1-T2 carcinoma of the pyriform sinus.
  • PURPOSE: To report long-term results using radiotherapy with or without a planned neck dissection for T1-T2 carcinoma of the pyriform sinus.
  • Moderate to severe long-term complications developed in 12% of patients.
  • The addition of adjuvant chemotherapy is unlikely to improve the probability of organ preservation, but might improve locoregional control for patients with advanced nodal disease.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / surgery. Laryngeal Neoplasms / radiotherapy. Laryngeal Neoplasms / surgery. Larynx / surgery. Neck Dissection. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Postoperative Complications. Salvage Therapy. Time. Treatment Outcome

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  • [Copyright] Copyright 2001 John Wiley & Sons, Inc.
  • (PMID = 11295808.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Kania R, Hans S, Garcia D, Brasnu D, De Mones E, Laccourreye O: Supracricoid hemilaryngopharyngectomy in patients with invasive squamous cell carcinoma of the pyriform sinus. Part II: Incidence and consequences of local recurrence. Ann Otol Rhinol Laryngol; 2005 Feb;114(2):95-104
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  • [Title] Supracricoid hemilaryngopharyngectomy in patients with invasive squamous cell carcinoma of the pyriform sinus. Part II: Incidence and consequences of local recurrence.
  • Supracricoid hemilaryngopharyngectomy (SCHLP) was performed in 147 patients over a 19-year period for previously untreated invasive squamous cell carcinoma of the pyriform sinus.
  • Before operation, 97.4% of patients had an induction chemotherapy regimen.
  • As a function of T stage, the 5-year actuarial local control estimates were 96.2%, 91.1%, 92.9%, and 62.6% in patients with tumors classified as T1, T2, T3, and T4a, respectively.
  • On univariate analysis, the overall local recurrence rate varied significantly, from 5.3% to 55.6% if the apex of the pyriform sinus was invaded (p = .02), 6.9% to 18.7% if the posterior pharyngeal wall was invaded (p = .03), and 6.3% to 60% if the margins of resection were positive (p = .02).
  • In a stepwise regression model, positive margins of resection (odds ratio, 8.4; 95% confidence interval, 2.2 to 32.2; p = .002) and invasion of the apex of the pyriform sinus (odds ratio, 6.1; 95% confidence interval, 1.1 to 33.3; p = .04) were the variables statistically associated with an increased risk of local recurrence.
  • From an oncological perspective, these results suggest that SCHLP should become a major tool in the armamentarium of the head and neck surgeon and should be integrated into future trials aimed at organ preservation in patients with invasive squamous cell carcinoma of the pyriform sinus.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Laryngectomy / methods. Neoplasm Recurrence, Local / epidemiology. Pharyngeal Neoplasms / surgery. Pharyngectomy / methods

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  • (PMID = 15757187.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Lajtman Z, Manestar D: A comparison of surgery and radiotherapy in the management of advanced pyriform fossa carcinoma. Clin Otolaryngol Allied Sci; 2001 Feb;26(1):59-61

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  • [Title] A comparison of surgery and radiotherapy in the management of advanced pyriform fossa carcinoma.
  • This retrospective study analyses the outcome of treatment of 61 patients with advanced carcinoma of the pyriform fossa.
  • Thirty-two patients (group 1) underwent surgery and postoperative radiotherapy and 29 patients (group 2) had induction chemotherapy followed by radiotherapy.
  • The local recurrence-free survival at 5 years from the completion of therapy for group 1 was 54%, compared to 61% for group 2.
  • Non-surgical therapy for advanced stage pyriform fossa cancer provides survival comparable with that achieved with the standard approach of surgery and postoperative radiotherapy.
  • But, however, despite the therapy, the outcome is poor.
  • [MeSH-major] Carcinoma / radiotherapy. Carcinoma / surgery. Paranasal Sinus Neoplasms / radiotherapy. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 11298170.001).
  • [ISSN] 0307-7772
  • [Journal-full-title] Clinical otolaryngology and allied sciences
  • [ISO-abbreviation] Clin Otolaryngol Allied Sci
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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12. Walvekar RR, Pantvaidya GH, Desai SB, Chaukar DA, D'Cruz AK: Urinary bladder metastasis--an unusual presentation of distant spread from a primary pyriform sinus cancer: a case report. Auris Nasus Larynx; 2006 Dec;33(4):493-5
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  • [Title] Urinary bladder metastasis--an unusual presentation of distant spread from a primary pyriform sinus cancer: a case report.
  • We present a report of a patient with a treated and controlled pyriform sinus cancer who presented with complaints of dysuria, 8 months after completion of treatment.
  • Cystoscopy revealed a bladder mass and biopsy confirmed it to be a metastatic squamous cell carcinoma.
  • On further investigation, the patient was found to have disseminated disease for which chemotherapy was instituted.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Hypopharyngeal Neoplasms / pathology. Urinary Bladder Neoplasms / secondary

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  • (PMID = 16920307.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Fang JG, Liang EH, Luan XY, Wang TD: [Laryngeal function preservation in comprehensive therapy of carcinoma of pyriform sinus]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2000 Mar;14(3):104-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Laryngeal function preservation in comprehensive therapy of carcinoma of pyriform sinus].
  • OBJECTIVE: To investigate the sufficiency of comprehensive therapy in the preservation of laryngeal function of carcinoma of pyriform sinus.
  • METHOD: Since 1986, 33 cases of pyriform sinus carcinoma were treated, the clinical stages were as follows: stage I 2 cases, stage II 9 cases, stage III 12, stage IV 10.
  • The induced chemotherapy agents were cisplatin, methotrexate and pingyangmycin.
  • Surgical treatment include local dissection of tumor, partial hypopharynx and partial larynx dissection.
  • RESULT: Chemotherapy partial response rate was 42.4%, 3 years survive rate was 54.8%, 5 years survive rate was 38.7%.
  • CONCLUSION: The cisplatin centered combined induced chemotherapy was effective in the treatment of pyriform sinus, the laryngeal function preservation surgical treatment of pyriform sinus carcinoma in T1 T2 and selective T3 patients is practicable.
  • [MeSH-major] Hypopharyngeal Neoplasms / therapy. Larynx / physiopathology
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Prognosis. Survival Rate

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  • (PMID = 12541406.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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14. Amin R: Sustained complete remission of stage IV carcinoma of the pyriform fossa following chemotherapy. J Laryngol Otol; 2002 Feb;116(2):143-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sustained complete remission of stage IV carcinoma of the pyriform fossa following chemotherapy.
  • These tumours are frequently advanced at the time of diagnosis.
  • Treatment, thus appears difficult from the outset.
  • Although therapeutic protocols have improved, their often radical nature is synonymous with poor tolerance.
  • With neoadjuvant chemotherapy and reconstructive surgery, cure has become a possibility for an increasing number of patients.
  • However, sustained long-term remission following chemotherapy alone for advanced hypopharyngeal tumours has seldom been recorded.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Hypopharyngeal Neoplasms / drug therapy
  • [MeSH-minor] Aged. Aged, 80 and over. Cisplatin / administration & dosage. Doxorubicin / administration & dosage. Fluorouracil / administration & dosage. Humans. Lymphatic Metastasis. Male. Remission Induction. Tomography, X-Ray Computed

  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • Hazardous Substances Data Bank. DOXORUBICIN .
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  • (PMID = 11827593.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
  • [Number-of-references] 10
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15. Guo X, Shi YC, Fei SZ, Pan ZM: [Cervical lymph node metastasis of hypopharyngeal carcinoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Oct;40(10):779-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cervical lymph node metastasis of hypopharyngeal carcinoma].
  • OBJECTIVE: To investigate the characteristic of cervical lymph node metastasis of hypopharyngeal carcinoma and its influence to the prognosis.
  • METHODS: One hundred and eight hypopharyngeal carcinoma patients who accepted treatments in the 1st Affiliated Hospital of China Medical University from 1985 to 2000 were reviewed retrospectively.
  • All of them accepted surgical treatment without pre-operative chemotherapy or radiotherapy.
  • Patients with pyriform sinus cancer occupied 92.6% (100/108) of all the cases.
  • Cervical lymph node metastasis rate of pyriform sinus cancer and posterior pharyngeal wall cancer were 74. 0% and 87.
  • CONCLUSIONS Cervical lymph node metastasis rate of hypopharyngeal carcinoma is high.
  • Cervical lymph node metastasis was one of the most significant prognostic factors of hypopharyngeal carcinoma.

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  • (PMID = 16408732.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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16. Paulino AF, Singh B, Shah JP, Huvos AG: Basaloid squamous cell carcinoma of the head and neck. Laryngoscope; 2000 Sep;110(9):1479-82
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basaloid squamous cell carcinoma of the head and neck.
  • OBJECTIVE/HYPOTHESIS: Basaloid squamous cell carcinoma (BSCC), an uncommon tumor with predilection for the upper aerodigestive tract, is a distinct variant of squamous carcinoma, because of its unique histological features and ominous clinical behavior.
  • Sites of origin included the larynx (4), tongue (3), pyriform sinus (3), nose (2), floor of mouth (2), mastoid (1), tonsil (1), epiglottis (1), nasopharynx (1), trachea (1), and palate (1).
  • Treatment modalities included surgery with or without chemotherapy or radiotherapy in 13 patients, chemotherapy with irradiation in 2, chemotherapy alone in 2, and radiotherapy alone in 3.
  • Four were alive with disease at the time of writing and five died of disease.
  • Greater number of patients must be studied and compared with age-matched and stage-matched controls of conventional squamous cell carcinoma to determine whether the poor clinical outcome is related more to high-stage presentation or to the tumor's high-grade malignant cytological features.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
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  • (PMID = 10983946.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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17. Yamazaki H, Inoue T, Tanaka E, Yoshida K, Imai A, Yoshioka Y, Nakamura H, Yoshida J, Inoue T: Radiation and low dose adriamycin for the treatment of carcinoma of the hypopharynx. Anticancer Res; 2000 Nov-Dec;20(6C):4713-20
Hazardous Substances Data Bank. DOXORUBICIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiation and low dose adriamycin for the treatment of carcinoma of the hypopharynx.
  • PURPOSE: To evaluate the utility of adriamycin in radiation therapy for hypopharyngeal cancer.
  • PATIENTS AND METHODS: Forty-five patients with hypopharyngeal carcinoma without distant metastasis were treated.
  • /once a week, median 64 mg) concurrently with radiation therapy to 38 patients, 76% (34 out of 45) of whom were in an advanced stage (III or IV).
  • Radiation therapy achieved an 84% (38 out of 45) response rate at 40 Gy.
  • Treatment without voice function loss was attained for 16 patients, consisting of 15 local CR (all T1 and 12 out of 26 T2 tumors) by radical radiation therapy and one posterior wall resection for a T2 tumor.
  • In 18 patients with T2 cancer originating from the pyriform sinus, 69% local control was obtained for patients using adriamycin compared with 20% for patients without adriamycin (p = 0.17).
  • CONCLUSIONS: Radiation therapy using low dose adriamycin with or without follow-up surgery is safe and has potential to be a good option.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Doxorubicin / therapeutic use. Hypopharyngeal Neoplasms / drug therapy. Hypopharyngeal Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Combined Modality Therapy / adverse effects. Dose-Response Relationship, Radiation. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Radiotherapy / adverse effects. Survival Rate. Time Factors

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  • (PMID = 11205206.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin
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18. Yu F, Dong YL, Zu ZJ, Zhan XD, Shu JH, Yang JS, Han GS, Lu LC, Zhang K, Sun HJ, Ren KJ: [Surgical management of hypopharyngeal cancer]. Zhonghua Er Bi Yan Hou Ke Za Zhi; 2003 Aug;38(4):295-9
Genetic Alliance. consumer health - Hypopharyngeal cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Two hundred and ninety-three cases of hypopharyngeal cancer with surgical management were reviewed retrospectively, and 222 cases were originated from pyriform sinus, 13 from post-cricoid, and 21 from posterior pharyngeal wall.
  • Radiotherapy (37 cases), operation only (56 cases) and the combined treatment (operation plus radiation or chemotherapy, 200 cases) were adopted.
  • The analysis of survival rates revealed a significant difference between combined therapy and radiotherapy.
  • Conservation laryngectomy improves the quality of patient's life, and combined therapy is the best choice for hypopharyngeal cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Hypopharyngeal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Laryngectomy. Larynx / physiopathology. Larynx / surgery. Male. Middle Aged. Quality of Life. Reconstructive Surgical Procedures. Survival Rate. Treatment Outcome

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  • (PMID = 14743643.001).
  • [ISSN] 0412-3948
  • [Journal-full-title] Zhonghua er bi yan hou ke za zhi
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Chen SW, Yang SN, Liang JA, Lin FJ, Tsai MH: Prognostic impact of tumor volume in patients with stage III-IVA hypopharyngeal cancer without bulky lymph nodes treated with definitive concurrent chemoradiotherapy. Head Neck; 2009 Jun;31(6):709-16
Genetic Alliance. consumer health - Hypopharyngeal cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic impact of tumor volume in patients with stage III-IVA hypopharyngeal cancer without bulky lymph nodes treated with definitive concurrent chemoradiotherapy.
  • The pyriform sinus was the principal site of involvement in the 63 cases.
  • CONCLUSION: A patient's pGTV is a strong outcome predictor for hypopharyngeal cancer treatment using CCRT.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / therapy. Radiotherapy, Conformal / methods
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Cohort Studies. Combined Modality Therapy. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Probability. Prognosis. Proportional Hazards Models. Radiotherapy Dosage. Retrospective Studies. Risk Assessment. Survival Analysis. Taiwan. Treatment Outcome. Tumor Burden / drug effects. Tumor Burden / radiation effects

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc.
  • (PMID = 19260114.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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