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Items 1 to 28 of about 28
1. Okutur K, Hasbal B, Aydin K, Bozkurt M, Namal E, Oz B, Kaynak K, Demir G: Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia. J Korean Med Sci; 2010 Dec;25(12):1805-8
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  • [Title] Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia.
  • Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported.
  • Chest tomography showed a mass in the right middle lobe.
  • Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG.
  • Computed tomography detected recurrence and chemotherapy was started.
  • After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass.
  • βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Chorionic Gonadotropin, beta Subunit, Human / blood. Gynecomastia / etiology. Lung Neoplasms / diagnosis
  • [MeSH-minor] Brain Neoplasms / radiotherapy. Brain Neoplasms / secondary. Humans. Lymph Nodes / surgery. Male. Middle Aged. Recurrence. Risk Factors. Tomography, X-Ray Computed

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  • (PMID = 21165299.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
  • [Other-IDs] NLM/ PMC2995238
  • [Keywords] NOTNLM ; Chorionic Gonadotropin / Gynecomastia / Lung Neoplasms / Pleomorphic Carcinoma
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2. Rossi G, Cavazza A, Marchioni A, Migaldi M, Bavieri M, Facciolongo N, Petruzzelli S, Longo L, Tamberi S, Crinò L: Kit expression in small cell carcinomas of the lung: effects of chemotherapy. Mod Pathol; 2003 Oct;16(10):1041-7
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  • [Title] Kit expression in small cell carcinomas of the lung: effects of chemotherapy.
  • A significant number of small cell lung carcinomas shows overexpression of the proto-oncogene c-kit product, a tyrosine kinase known as Kit or CD117.
  • This molecular pathway seems somewhat implicated in promoting the neoplastic growth of small cell lung carcinoma.
  • The current pharmacological availability of its selective inhibitor, together with the promising clinical results in the management of CD117-positive neoplasms such as advanced gastrointestinal stromal tumors, aroused great interest among oncologists in also adopting this therapeutic strategy in other CD117-positive tumors.
  • We evaluated a series of 27 small cell lung carcinomas, comparing the expression of CD117 of the primary naïve tumor (before first-line chemotherapy) with the expression of the same neoplasm after postchemotherapy relapse.
  • At diagnosis, 21 of 27 cases (78%) showed strong immunoreactivity for CD117.
  • No originally CD117-negative small cell carcinomas displayed immunoreactivity after chemotherapy.
  • CD117 expression was not statistically correlated with overall survival, occurrence of chemoresistance, or clinical response to chemotherapy.
  • We also evaluated CD117 expression in a series of 46 surgically resected non-small cell lung carcinomas (8 squamous cell carcinomas, 10 adenocarcinomas, 5 pleomorphic carcinomas, 10 typical and 3 atypical carcinoids, and 10 large cell neuroendocrine carcinomas).
  • We speculate that loss of CD117 expression after chemotherapy in a high proportion of SCLC indicates that in this tumor, Kit unlikely represents the product of a constitutive mutation, as instead shown in gastrointestinal stromal tumors.
  • Keeping this finding in mind, oncologists could re-test CD117 expression in relapsing small cell lung carcinomas in order to establish the best candidates for enrollment in ongoing clinical trials with Kit inhibitors.
  • Practically speaking, CD117 may be helpful in discriminating between pulmonary high-grade neuroendocrine tumors and other histotypes, but pathologists should be aware that treated small cell lung carcinomas may remain unstained in a not insignificant number of cases.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Carcinoma, Small Cell / metabolism. Lung Neoplasms / drug therapy. Lung Neoplasms / metabolism. Proto-Oncogene Proteins c-kit / metabolism

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  • (PMID = 14559988.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; Q20Q21Q62J / Cisplatin
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3. Ito K, Oizumi S, Fukumoto S, Harada M, Ishida T, Fujita Y, Harada T, Kojima T, Yokouchi H, Nishimura M, Hokkaido Lung Cancer Clinical Study Group: Clinical characteristics of pleomorphic carcinoma of the lung. Lung Cancer; 2010 May;68(2):204-10
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  • [Title] Clinical characteristics of pleomorphic carcinoma of the lung.
  • BACKGROUND: Pleomorphic carcinoma of the lung is a malignant epithelial tumor that contains carcinomatous and sarcomatoid components.
  • METHOD: We retrospectively investigated 22 cases of pleomorphic carcinoma of the lung.
  • Nineteen patients were male and 3 were female, and their mean age at diagnosis was 68.3 years (+/-10.1).
  • Chest computed tomography (CT) findings revealed that the tumors were quite large (mean diameter 45.3+/-21.9mm; range 14-110mm), and 21 tumors were peripherally located.
  • Positron emission tomography with 18-fluorodeoxy-glucose (FDG-PET) was performed in 12 patients, and the Standardized Uptake Value (SUV) tended to be high (9.44+/-4.98).
  • Patients who had received surgical treatment with proper follow-up care survived longer than those who did not undergo surgery.
  • Responses to chemotherapy were generally poor, although 1 patient exhibited partial response to gefitinib.
  • CONCLUSIONS: Pulmonary pleomorphic carcinoma has strong malignant potential with frequent distant metastases, as has already been reported.
  • However, this study demonstrated that surgical treatment and appropriate follow-up therapy might result in better prognoses.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Lung Neoplasms / physiopathology
  • [MeSH-minor] Aged. Aged, 80 and over. Disease Progression. Drug Resistance, Neoplasm. Female. Hemoptysis. Humans. Male. Middle Aged. Neoplasm Metastasis. Positron-Emission Tomography. Retrospective Studies. Tomography, X-Ray Computed

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19577320.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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4. Nosaka S, Murayama M, Beppu T, Katsuda K, Nakao M, Enomoto M: [Pleomorphic carcinoma of the lung; report of a case]. Kyobu Geka; 2008 Jun;61(6):512-5
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  • [Title] [Pleomorphic carcinoma of the lung; report of a case].
  • Chest radiography and computed tomography (CT) showed a tumor mass near the right hilum and atelectasis of the middle lobe.
  • Histological findings showed adenocarcinoma comprised of spindle cell component, finally diagnosing as pleomorphic carcinoma of the lung.
  • After the operation, systemic chemotherapy, including paclitaxel and carboplatin was performed.
  • [MeSH-major] Carcinoma / surgery. Lung Neoplasms / surgery
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / secondary. Carboplatin / administration & dosage. Chemotherapy, Adjuvant. Fatal Outcome. Female. Humans. Lymph Node Excision. Paclitaxel / administration & dosage. Pneumonectomy. Treatment Outcome

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  • (PMID = 18536305.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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5. Tsushima M, Matsuo K, Mizuta M, Ueda Y, Fujiwara K, Yonei T, Yamadori I, Sato T: [Pleomorphic carcinoma of the lung with uncommon initial manifestation of intestinal perforation]. Nihon Kokyuki Gakkai Zasshi; 2009 Jun;47(6):507-11
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  • [Title] [Pleomorphic carcinoma of the lung with uncommon initial manifestation of intestinal perforation].
  • A 47-year-old woman suddenly developed abdominal pain and visited the emergency room of our hospital.
  • Histological examination of the resected tissue revealed undifferentiated carcinoma, but the histological differentiation could not be determined.
  • We used immunohistochemical staining to distinguish primary non-small cell lung cancer from colon cancer; the resected tumor was positive for TTF-1 and CK7, but negative for CK20.
  • Therefore, by using immunohistochemical staining we could diagnose the tumor of the large intestine as metastasis from non-small cell lung cancer.
  • After the operation, systemic chemotherapy with carboplatin and docetaxel was repeated, but the lung tumor did not regress and the patient died.
  • Autopsy examination confirmed the histology of the lung tumor as pleomorphic carcinoma.
  • In Japan, this is the first report in which the initial manifestation of lung cancer was perforation of the large intestine due to metastasis.
  • [MeSH-major] Carcinoma / pathology. Intestinal Perforation / etiology. Lung Neoplasms / pathology. Sigmoid Diseases / etiology. Sigmoid Neoplasms / secondary

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  • (PMID = 19601528.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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6. Nakamura S, Horiuchi N, Katsura D, Shichijo K, Yoshida S, Harada E, Matsushita T, Oshima Y, Matsuzaki Y, Tamaki Y, Kimura S, Takeichi T, Fujimoto H, Masuda K, Iwasaka N, Shinomiya S: [A long-surviving patient with lung pleomorphic carcinoma treated with postoperative carboplatin and paclitaxel combination chemotherapy]. Gan To Kagaku Ryoho; 2008 Jun;35(6):965-8
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  • [Title] [A long-surviving patient with lung pleomorphic carcinoma treated with postoperative carboplatin and paclitaxel combination chemotherapy].
  • Chest computed tomography revealed a tumor of right upper lung and interstitial pneumonia in the surrounding lung parenchyma.
  • He was operated upon and diagnosed with stage IIB pleomorphic carcinoma of the lung with invasion of the chest wall.
  • He underwent three courses of postoperative carboplatin (CBDCA) (area under the curve 5 on day 1, every 3 weeks and paclitaxel(PTX) (200 mg/m(2); day 1, every 3 weeks) combination chemotherapy.
  • According to previous reports, lung pleomorphic carcinoma is aggressive and has a poor prognosis.
  • Further, the significance of chemotherapy in the management of this disease has not been established.
  • Postoperative combination chemotherapy of CBDCA and PTX may result in a good prognosis for this disease.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carboplatin / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology. Paclitaxel / therapeutic use
  • [MeSH-minor] Humans. Male. Middle Aged. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18633226.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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7. Ushiki A, Koizumi T, Kobayashi N, Kanda S, Yasuo M, Yamamoto H, Kubo K, Aoyagi D, Nakayama J: Genetic heterogeneity of EGFR mutation in pleomorphic carcinoma of the lung: response to gefitinib and clinical outcome. Jpn J Clin Oncol; 2009 Apr;39(4):267-70
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  • [Title] Genetic heterogeneity of EGFR mutation in pleomorphic carcinoma of the lung: response to gefitinib and clinical outcome.
  • Somatic epidermal growth factor receptor (EGFR) mutations in exons 19 and 21 have been found in non-small cell lung cancer (NSCLC) and are associated with the therapeutic response to gefitinib in patients with advanced NSCLC.
  • We report a case of pleomorphic carcinoma of the lung with different EGFR mutations.
  • Prior to gefitinib treatment, an exon 19 deletion of EGFR mutation was positive in the specimens obtained from pleural effusion and left cervical lymph node, histologically proven to be adenocarcinoma.
  • However, the response to gefitinib was poor and the patient died of progressive disease 4 months after the initiation of gefitinib therapy.
  • Postmortem examination revealed the major histological component to be of the sarcomatoid or pleomorphic type with scant mixed adenocarcinoma, resulting in a histological diagnosis of pleomorphic carcinoma of the lung.
  • Although the adenocarcinomatous tissue was still positive for exon 19 deletion of EGFR mutation alone, sarcomatous components had both the exons 19 deletion and 20 T790M mutation concomitantly, thought to be a gefitinib resistance mutation.
  • Pulmonary pleomorphic carcinoma is a rare NSCLC composed of biphasic and heterogeneous malignant cell populations.
  • The present case suggested that expression of different EGFR mutations is related to the biphasic histological appearance in pulmonary pleomorphic carcinoma.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / genetics. Genes, erbB-1 / genetics. Lung Neoplasms / drug therapy. Lung Neoplasms / genetics. Neoplasms, Multiple Primary / drug therapy. Neoplasms, Multiple Primary / genetics. Sequence Deletion
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / genetics. Adenocarcinoma / secondary. Antineoplastic Agents / therapeutic use. Fatal Outcome. Humans. Lymphatic Metastasis. Male. Middle Aged. Quinazolines / therapeutic use. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Treatment Outcome

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  • (PMID = 19155283.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
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8. Yilmaz A, Sulu E, Arinç S, Saltürk C, Okur E, Aksoy F, Halezeroğlu S: Pleomorphic carcinoma of the lung: a report of six cases. Tuberk Toraks; 2007;55(3):290-4
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  • [Title] Pleomorphic carcinoma of the lung: a report of six cases.
  • We presented six patients with pleomorphic carcinoma of the lung.
  • The diagnosis of pleomorphic carcinoma was established with cutting needle biopsy in one case and with thoracotomy in five cases.
  • Epithelial component was squamous cell carcinoma in three cases and adenocarcinoma in the other three cases.
  • She received chemotherapy and died two months after therapy.
  • Treatment modality was lobectomy in three cases and pneumonectomy in two cases.
  • Survival time for patients after surgery was 2 to 20 months.
  • In conclusion, pleomorphic carcinoma is a rare tumor of the lung.
  • Diagnosis is frequently established with thoracotomy.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17978928.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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9. Kikuchi R, Isowa N, Tokuyasu H, Kawasaki Y, Onuma H, Miura H: Three cases of resected pleomorphic carcinoma. Ann Thorac Cardiovasc Surg; 2010 Aug;16(4):264-9
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  • [Title] Three cases of resected pleomorphic carcinoma.
  • Pleomorphic carcinoma (PC) is a rare malignancy of the lung.
  • After 3 courses of adjuvant chemotherapy, he is alive without relapse 56 months after the operation.
  • Case 2: The patient was a 60-year-old man with left high back pain whose chest roentgenogram showed a mass shadow in the left upper lung field.
  • A left upper lobectomy with partial resection of S6 was performed after induction chemotherapy.
  • He died of infection 4 months after the operation during adjuvant chemotherapy.
  • Case 3: A 78-year-old man with hemoptysis underwent aortic arch replacement after a diagnosis of impending rupture of an aortic aneurysm.
  • During the operation, a tumor in the left upper lung lobe was detected.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / pathology. Lung Neoplasms / surgery
  • [MeSH-minor] Aged. Antineoplastic Agents / administration & dosage. Chemotherapy, Adjuvant. Humans. Male. Middle Aged. Neoadjuvant Therapy. Pneumonectomy

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  • (PMID = 21057444.001).
  • [ISSN] 2186-1005
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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10. Aketa A, Yamada G, Aketa K, Ohnishi T, Takahashi Y, Kudoh K, Tanaka S, Shiratori M, Takahashi H, Watanabe A, Satoh M, Abe S: [Two younger male patients with rapidly progressing pulmonary pleomorphic carcinoma]. Nihon Kokyuki Gakkai Zasshi; 2004 Feb;42(2):164-9
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  • [Title] [Two younger male patients with rapidly progressing pulmonary pleomorphic carcinoma].
  • We report 2 cases of pulmonary pleomorphic carcinoma.
  • The pathological diagnosis was pleomorphic carcinoma, p-T4 N2 M0.
  • After the operation, we performed systemic chemotherapy, including cisplatin and irinotecanm with little effect (PD).
  • Pathological diagnosis was pleomorphic carcinoma, p-T4 N0 M0.
  • After the operation, the mediastinum was subjected to radiation therapy.
  • We performed systemic chemotherapy with substances including cisplatin, gemcitabine and vinorelbine, but with little effect (PD).
  • Both cases had rapidly growing neoplasms showing little sensitivity to chemotherapy or radiotherapy.
  • Pulmonary pleomorphic carcinoma is suggested to be type of lung cancer with a poor prognosis when the tumor is not resected in the early stages.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / therapy. Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / therapy. Lung Neoplasms / diagnosis. Lung Neoplasms / therapy. Neoplasms, Multiple Primary
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / therapy. Adult. Age Factors. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy. Chemotherapy, Adjuvant. Disease Progression. Fatal Outcome. Humans. Lymph Node Excision. Male. Neoplasm Invasiveness. Neoplasm Staging. Pneumonectomy. Radiotherapy, Adjuvant

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  • (PMID = 15007917.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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11. Yangui I, Smaoui M, Khabir A, Ayoub A, Boudawara T: [A rare primary pulmonary tumor: pleomorphic carcinoma]. Presse Med; 2007 Feb;36(2 Pt 1):243-6
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  • [Title] [A rare primary pulmonary tumor: pleomorphic carcinoma].
  • INTRODUCTION: Pleomorphic carcinoma is a rare malignancy in the family of non-small cell lung cancers.
  • Computed tomography showed a peripheral tumor of the right upper lobe, and the radiography showed signs of malignancy.
  • Pathologic examination of the transparietal biopsy confirmed the tumor diagnosis, classifying it as stage III A.
  • The patient underwent 2 cycles of induction chemotherapy that combined gemcitabine and cisplatin.
  • The patient died 4 months after diagnosis.
  • DISCUSSION: Pleomorphic carcinoma is identified by purely histologic criteria: the concomitant presence of malignant epithelial and homologous sarcomatoid spindle-cell components.
  • Like the other non-small cell lung cancers, treatment is primarily surgical, and the invasive character of this tumor makes it very difficult.
  • Pleomorphic carcinoma has a poorer prognosis than conventional non-small cell lung cancers despite surgery, irradiation and chemotherapy, because relapse occurs early.
  • [MeSH-major] Carcinoma / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Humans. Radiography, Thoracic. Treatment Outcome

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  • (PMID = 17259034.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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12. Hirano H, Yoshida T, Sakamoto T, Yoshimura H, Fukuoka M, Tachibana S, Saito H, Ohkubo E, Nakasho K, Nishigami T: Pulmonary pleomorphic carcinoma producing hCG. Pathol Int; 2007 Oct;57(10):698-702
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  • [Title] Pulmonary pleomorphic carcinoma producing hCG.
  • An 80-year-old woman with a pleomorphic carcinoma (PC) producing hCG was admitted to Nippon Steel Hirohata Hospital because of an abnormal shadow on CT seen during a follow-up examination after surgery for breast cancer.
  • A diagnosis of PC was made due to hCG expression in approximately 20% of the spindle and polygonal cells on immunohistology.
  • The patient died due to metastases 1 year after the operation, even though the patient had been at stage 1B at the time of the operation and appropriate chemotherapy had been given.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Non-Small-Cell Lung / metabolism. Carcinosarcoma / metabolism. Chorionic Gonadotropin / metabolism. Lung Neoplasms / metabolism
  • [MeSH-minor] Aged, 80 and over. Combined Modality Therapy. Fatal Outcome. Female. Humans. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 17803660.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin
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13. Raveglia F, Mezzetti M, Panigalli T, Furia S, Giuliani L, Conforti S, Meda S: Personal experience in surgical management of pulmonary pleomorphic carcinoma. Ann Thorac Surg; 2004 Nov;78(5):1742-7
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  • [Title] Personal experience in surgical management of pulmonary pleomorphic carcinoma.
  • BACKGROUND: Pleomorphic carcinoma is a rare epithelial malignant tumor.
  • Pulmonary pleomorphic carcinoma was introduced by the 1999 World Health Organization classification as a new peculiar type of lung carcinoma showing concurrent malignant epithelial and sarcomatoid spindle cell elements.
  • My colleagues and I report a series of patients surgically treated for pulmonary pleomorphic carcinoma to describe our experience with this malignant neoplasm.
  • METHODS: Twenty cases of pleomorphic pulmonary carcinoma were collected and studied clinicopathologically.
  • Histologic diagnosis was established by using light microscopic examination and immunohistochemistry.
  • RESULTS: We postoperatively diagnosed 20 cases of pleomorphic carcinoma: 14 cases were exclusively spindle and giant-cell carcinomas, 2 cases were spindle and giant-cell carcinoma combined with adenocarcinoma, 2 were combined with squamous cell carcinoma, and 2 were combined with large cell carcinoma.
  • CONCLUSIONS: The prognosis of patients with pleomorphic carcinoma was poor, despite surgery and adjuvant chemotherapy, because of early relapse of disease.
  • In case of preoperatively proven pulmonary pleomorphic carcinoma, surgery should be recommended to N0 patients.
  • [MeSH-major] Carcinoma / surgery. Lung Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Carcinoma, Giant Cell / mortality. Carcinoma, Giant Cell / pathology. Carcinoma, Giant Cell / surgery. Cell Differentiation. Disease-Free Survival. Female. Follow-Up Studies. Humans. Life Tables. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 15511465.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 20
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14. Nagase H, Yokouchi H, Ide Y, Okada K, Yanagisawa T, Mukai R, Ota H, Maruyama K, Murata K, Kinuta M: [The case of a person who was revealed by adrenal metastasis of pulmonary pleomorphic carcinoma]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2747-9
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  • [Title] [The case of a person who was revealed by adrenal metastasis of pulmonary pleomorphic carcinoma].
  • Computed tomography revealed a tumor of right adrenal gland and a tumor of upper lobe of the right lung.
  • At first adrenal tumor was diagnosed as primary adrenal cancer because its histological findings did not coincide with those of common histologic types of lung cancer.
  • As there were possibilities that one of adrenal or lung tumor was primary and the other was metastatic or both of the two were double primary, we performed right upper lobectomy.
  • Lung tumor was diagnosed as primary pleomorphic carcinoma containing spindle-shaped tumor cells and adenocarcinoma, and then the diagnosis of adrenal tumor was corrected as metastasis of lung cancer.
  • Two months after the lung operation, cervical lymph node swelling, metastasis of stomach and local recurrence of adrenal tumor appeared.
  • After he underwent six courses of systemic chemotherapy of carboplatin and paclitaxel, a clinical complete response was obtained and no recurrence is observed for 4 years.
  • [MeSH-major] Adenocarcinoma / pathology. Adrenal Gland Neoplasms / secondary. Lung Neoplasms / pathology
  • [MeSH-minor] Adrenalectomy. Humans. Male. Middle Aged. Neoplasms, Unknown Primary / diagnosis. Pneumonectomy

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  • (PMID = 21224700.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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15. Uruga H, Fujii T, Kurosaki A, Hanada S, Takaya H, Miyamoto A, Morokawa N, Kishi K: [A case of pulmonary tumor thrombotic microangiopathy caused by carcinoma (salivary duct carcinoma) ex pleomorphic adenoma]. Nihon Kokyuki Gakkai Zasshi; 2010 Jun;48(6):463-8
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  • [Title] [A case of pulmonary tumor thrombotic microangiopathy caused by carcinoma (salivary duct carcinoma) ex pleomorphic adenoma].
  • A 53-year-old man with carcinoma (salivary duct carcinoma) ex pleomorphic adenoma was admitted to our hospital because of dyspnea.
  • He received chemotherapy in July 2007, and was subsequently followed up without chemotherapy.
  • Tc-99m-MAA lung perfusion images showed multiple small defects in both lungs.
  • A diagnosis of pulmonary tumor thrombotic microangiopathy (PTTM) was made.
  • [MeSH-major] Carcinoma / complications. Lung Neoplasms / complications. Salivary Ducts. Salivary Gland Neoplasms / complications. Thrombotic Microangiopathies / etiology
  • [MeSH-minor] Humans. Lung / blood supply. Male. Microcirculation. Middle Aged

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  • (PMID = 20608093.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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16. Kakegawa S, Kawashima O, Sugano M, Nagashima T, Morishita Y: [Pleomorphic lung cancer; a clinicopathologic study]. Kyobu Geka; 2006 Feb;59(2):110-3
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  • [Title] [Pleomorphic lung cancer; a clinicopathologic study].
  • Pulmonary pleomorphic carcinoma is a comparatively rare histologic type of lung carcinoma, and the incidence among all lung carcinomas has been reported to be 0.4%.
  • We reported our experience with 8 patients who had been diagnosed as pulmonary pleomorphic carcinoma, and discussed clinicopathologically the preoperative diagnosis and treatment.
  • In 2 of 8 patients, preoperative transbronchial lung biopsy revealed spindle cell component, highly suggesting pulmonary pleomorphic carcinoma.
  • All patients underwent surgical treatment and 2 of then had incomplete resections because of intrathoracic disseminations or carcinomatous pericarditis.
  • Although the preoperative diagnosis of biphasic tumor such as pulmonary pleomorphic carcinoma is difficult, it is possible to suspect the diagnosis when sarcomatous components were detected by preoperative biopsy.
  • The efficacy of chemotherapy and radiotherapy have not been established yet, and thus we would like to emphasize that surgery might be the treatment of choice.
  • [MeSH-major] Lung Neoplasms / pathology. Neoplasms, Multiple Primary

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  • (PMID = 16482903.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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17. Yasunaga M, Ohishi Y, Nishimura I, Tamiya S, Iwasa A, Takagi E, Inoue T, Yahata H, Kobayashi H, Wake N, Tsuneyoshi M: Ovarian undifferentiated carcinoma resembling giant cell carcinoma of the lung. Pathol Int; 2008 Apr;58(4):244-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian undifferentiated carcinoma resembling giant cell carcinoma of the lung.
  • Giant cell carcinoma (GCC) is a highly aggressive variant of sarcomatoid carcinoma of the lung.
  • To date, however, there have been no reported cases of ovarian carcinoma mainly composed of GCC.
  • Herein is reported the case of a 54-year-old Japanese woman with an undifferentiated ovarian carcinoma producing granulocyte colony-stimulating factor (G-CSF) and an inflammatory cytokine.
  • Histologically, the tumor was composed of cohesive nests or discohesive pleomorphic mononucleated or multinucleated tumor giant cells, accompanied by inflammatory cell infiltration and emperipolesis.
  • Adjuvant chemotherapy was administered but induced severe heart failure and severe neutropenia, probably due to the presence of hypercytokinemia and excess G-CSF.
  • Upon the appearance of these fatal side-effects the chemotherapy was immediately discontinued and replaced with radiotherapy.
  • The recognition of this type of ovarian tumor is important for clinical management, because adjuvant chemotherapy is the standard treatment for clinical management of epithelial ovarian cancer.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Giant Cell / diagnosis. Lung Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Biomarkers, Tumor / metabolism. Chemotherapy, Adjuvant / adverse effects. Diagnosis, Differential. Disease-Free Survival. Fallopian Tubes / surgery. Female. Granulocyte Colony-Stimulating Factor / metabolism. Humans. Middle Aged. Mucin-1 / metabolism. Ovariectomy. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 18324918.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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18. Huang R, Jaffer S: Imprint cytology of metastatic sialoblastoma. A case report. Acta Cytol; 2003 Nov-Dec;47(6):1123-6
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  • There is only 1 brief description of the cytologic findings of metastatic sialoblastoma and 1 poorly documented case of lung metastasis in the literature.
  • CASE: A 75-month-old girl with a history of recurrent sialoblastoma initially diagnosed at 21 months and treated with multiple incomplete surgical excisions, chemotherapy and radiation presented with a solitary lung nodule.
  • The differential diagnoses include neoplasms composed of either basaloid cells and/or admixed hyaline matrix material and included pleomorphic adenoma, basal cell adenoma and adenoid cystic carcinoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / secondary. Lung Neoplasms / secondary. Neoplasms, Germ Cell and Embryonal / secondary. Neoplasms, Glandular and Epithelial / secondary. Parotid Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child, Preschool. Diagnosis, Differential. Disease Progression. Epithelial Cells / pathology. Female. Humans. Neoplasm Metastasis / pathology. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Parotid Gland / pathology. Parotid Gland / surgery. Treatment Outcome

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  • (PMID = 14674095.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Amin RM, Kokubo T, Hiroshima K, Narita M, Itou K, Kuroki M, Tanizawa T, Nakatani Y: Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma. Pathol Int; 2005 Oct;55(10):649-54
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  • [Title] Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma.
  • Two years after testicular resection was carried out in a 40-year-old man that revealed mixed germ cell tumor of more than one histological type (seminoma, embryonal cell carcinoma, and yolk sac tumor), he presented with an asymptomatic pulmonary nodule in his left lower lobe.
  • Video-assisted thoracoscopic partial resection of the tumor revealed a 24 x 20 mm teratoma with somatic-type malignancy in which pleomorphic rhabdomyosarcoma was a major element.
  • One year later, asymptomatic tumor recurrence occurred at both edges of the stapler line as 22 x 20 mm and 10 x 5 mm nodules composed only of pleomorphic rhabdomyosarcoma.
  • Throughout the course there was no abdominal lymph node swelling detected by computed tomography (CT) and tumor markers were normal.
  • Adjuvant chemotherapy was started after the tumor recurrence.
  • Currently, the patient is still undergoing chemotherapy 5 months after the tumor recurrence.
  • In conclusion, despite the fact that primary pulmonary rhabdromyosarcoma is a rare neoplasm, metastatic pulmonary germ cell tumor with somatic-type malignancy showing predominantly rhabdomyosarcomatous differentiation should be considered in the differential diagnosis of such lesions of the lung.
  • [MeSH-major] Lung Neoplasms / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Rhabdomyosarcoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Male. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 16185296.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Hosono T, Ohno S, Nakazawa S, Oshikawa K, Bando M, Sohara Y, Sugiyama Y: [Two cases of lung cancer in the third decade of life]. Nihon Kokyuki Gakkai Zasshi; 2004 Sep;42(9):859-64
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  • [Title] [Two cases of lung cancer in the third decade of life].
  • We report two cases of lung cancer in the third decade of life.
  • A diagnosis of adenocarcinoma consisting of bronchial gland cells was made by bronchial biopsy.
  • Although he was treated with cisplatin-based chemotherapy and gefitinib, he died of lung cancer.
  • Since histologic examination at thoracotomy revealed lung cancer, left lower lobectomy and lymph node dissection were performed.
  • Histological examination of the resected specimen revealed pleomorphic carcinoma.
  • Although the absolute number of young adults with lung cancer has been increasing, the relative incidence among all cases of lung cancer has been decreasing.
  • In some cases, young adults with lung cancer have been misdiagnosed as having bronchial asthma or pulmonary tuberculosis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / radiography. Lung Neoplasms / radiography
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Bone Neoplasms / secondary. Female. Humans. Male. Quinazolines / therapeutic use. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 15500157.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; S65743JHBS / gefitinib
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21. Lewin SN, Aghajanian C, Moreira AL, Soslow RA: Extrauterine epithelioid trophoblastic tumors presenting as primary lung carcinomas: morphologic and immunohistochemical features to resolve a diagnostic dilemma. Am J Surg Pathol; 2009 Dec;33(12):1809-14
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  • [Title] Extrauterine epithelioid trophoblastic tumors presenting as primary lung carcinomas: morphologic and immunohistochemical features to resolve a diagnostic dilemma.
  • Our objective was to describe the clinicopathologic features of epithelioid trophoblastic tumors (ETTs) in a series of patients who presented with elevated beta-human chorionic gonadotrophin (hCG) levels and extrauterine lesions resembling primary lung carcinomas.
  • Imaging revealed isolated pulmonary lesions, 2 to 8.5 cm in size, resembling primary lung carcinomas.
  • Two patients received multiagent chemotherapy consisting of etoposide, methotrexate, dactinomycin, alternating with cisplatin and etoposide, and all underwent pulmonary resection.
  • Histologically, the cytologic features, epithelioid growth pattern, and hyaline-like material simulated the appearance of nonsmall cell lung carcinoma, but overall, the histologic features along with the immunophenotype supported classification as ETT.
  • The rarity of ETT and its resemblance to squamous and pleomorphic carcinomas of lung have led to diagnostic difficulties.
  • Correlating clinical indices with specific morphologic and immunohistochemical features can ensure diagnostic accuracy and appropriate treatment for favorable outcomes.
  • [MeSH-major] Epithelioid Cells / pathology. Immunohistochemistry. Lung Neoplasms / pathology. Trophoblastic Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Biomarkers, Tumor / blood. Chemotherapy, Adjuvant. Chorionic Gonadotropin, beta Subunit, Human / blood. Diagnosis, Differential. Endometrium / pathology. Female. Humans. Immunophenotyping. Middle Aged. Pneumonectomy. Predictive Value of Tests. Pregnancy. Thoracoscopy. Treatment Outcome. Up-Regulation

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  • (PMID = 19773636.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin, beta Subunit, Human
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22. Grundmann JU, Weisshaar E, Franke I, Bonnekoh B, Gollnick H: Lung carcinoma with congenital plantar keratoderma as a variant of Clarke-Howel-Evans syndrome. Int J Dermatol; 2003 Jun;42(6):461-3
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  • [Title] Lung carcinoma with congenital plantar keratoderma as a variant of Clarke-Howel-Evans syndrome.
  • A 32-year-old man was admitted to the Magdeburg University Hospital with icterus and for further diagnosis of suspected hepatitis.
  • The patient's history revealed the excision of a lymph node metastasis of the left groin showing pleomorphic macrocellular infiltrates, 2 months previously.
  • Further investigations revealed icterus of the sclera and multiple, firm tumors, which were located in the deep subcutaneous tissue, on the left hip, thigh, and buttock.
  • From thorough clinical, laboratory and staging investigations, a non-small-cell bronchogenic carcinoma, with metastases of the liver, kidneys, adrenal glands, and several skin sites, was diagnosed.
  • Chemotherapy could not be continued because of a Karnowsky index below 20%.
  • [MeSH-major] Keratoderma, Palmoplantar / genetics. Lung Neoplasms / drug therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Drug Therapy, Combination. Fatal Outcome. Fluorouracil / therapeutic use. Humans. Male. Mitomycin / therapeutic use. Neoplasm Metastasis

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  • (PMID = 12786874.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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23. Carvalho L: Reclassifying bronchial-pulmonary carcinoma: differentiating histological type in biopsies by immunohistochemistry. Rev Port Pneumol; 2009 Nov-Dec;15(6):1101-19
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  • [Title] Reclassifying bronchial-pulmonary carcinoma: differentiating histological type in biopsies by immunohistochemistry.
  • The current state of molecular knowledge on lung cancer demands a histological classification which goes beyond small-cell and non-small-cell carcinoma to provide support for tailored therapy in aiding in understanding of the drugs currently available.
  • As diagnosis and follow-up in the vast majority of lung cancer cases is based on biopsies and cytology samples, Immunohistochemical Bronchial Pulmonary Carcinoma Classification (IBPCC) is necessary to reveal the raft of characteristics available.
  • The immunohistochemical panel clarifies the main morphology and cytology characteristics to maintain the leading histological types as squamous cell carcinoma (high weight molecular cytokeratins/HWMC), adenosquamous carcinoma (CK7, TTF1, HWMA), neuroendocrine carcinoma (Chrg, Syn, CD56, TTF1, Ki67), adenocarcinoma (CK7, CK20, TTF1) and bring the polymorphic and pleomorphic carcinomas under a single banner of pleomorphic carcinoma (Ck7, TTF1, HWMC, VMT, Desmin, Actin) which shelters large cell carcinomas and sarcomatoid carcinomas.
  • Lung cancer chemotherapy will still be based on platinum and gemcitabine for the near future and the IBPCC is a simple and efficient tool for streamlining the registration of lung cancer histological characteristics in biopsies and other reduced samples to support clinical evidence and trials.
  • [MeSH-major] Adenocarcinoma / classification. Adenocarcinoma / pathology. Bronchial Neoplasms / classification. Bronchial Neoplasms / pathology. Lung Neoplasms / classification. Lung Neoplasms / pathology

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  • (PMID = 19859629.001).
  • [ISSN] 2172-6825
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] eng; por
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Portugal
  • [Number-of-references] 80
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24. McLean SR, Shousha S, Francis N, Lim A, Eccles S, Nathan M, Brock CS, Palmieri C: Metastatic ductal eccrine adenocarcinoma masquerading as an invasive ductal carcinoma of the male breast. J Cutan Pathol; 2007 Dec;34(12):934-8
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  • [Title] Metastatic ductal eccrine adenocarcinoma masquerading as an invasive ductal carcinoma of the male breast.
  • We report the case of a 38-year-old man with metastatic ductal eccrine adenocarcinoma (DEA) of the left breast responding to 5-flourouracil, epirubicin and cyclophosphamide (FEC) chemotherapy.
  • A punch biopsy of the breast lesion resulted in a diagnosis of metastatic invasive ductal carcinoma (IDC) of the breast.
  • He received palliative radiotherapy to the spine and also received six cycles of FEC chemotherapy and was subsequently commenced on tamoxifen and ibandronate.
  • There was a symptomatic and radiological response to the FEC chemotherapy.
  • This showed tumor cells that were polygonal with darkly stained pleomorphic nuclei and abundant eosinophilic cytoplasm and were also localized to areas of fibrotic stroma containing eccrine glands and ducts but did not appear to involve mammary tissue.
  • Both the morphological and the immunohistochemical characteristics of the tumor were consistent with a revised diagnosis of DEA rather than IDC.
  • In addition, clinical response to FEC by metastatic DEA has not been previously documented, and this therapeutic regimen warrants further investigation.
  • [MeSH-major] Adenocarcinoma / pathology. Breast Neoplasms, Male / pathology. Carcinoma, Ductal, Breast / pathology. Eccrine Glands / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Bone Density Conservation Agents / therapeutic use. Bone Neoplasms / secondary. Bone Neoplasms / therapy. Cyclophosphamide / therapeutic use. Diphosphonates / therapeutic use. Epirubicin / therapeutic use. Fluorouracil / therapeutic use. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Lymphatic Metastasis / pathology. Male. Radiotherapy. Tamoxifen / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 18001417.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Bone Density Conservation Agents; 0 / Diphosphonates; 094ZI81Y45 / Tamoxifen; 114084-78-5 / ibandronic acid; 3Z8479ZZ5X / Epirubicin; 8N3DW7272P / Cyclophosphamide; U3P01618RT / Fluorouracil
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25. Whatley WS, Thompson JW, Rao B: Salivary gland tumors in survivors of childhood cancer. Otolaryngol Head Neck Surg; 2006 Mar;134(3):385-8
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  • The most common second malignancies are acute leukemia, bone and soft tissue tumors, and carcinoma of the skin, breast, and thyroid.
  • RESULTS: Twelve survivors of childhood cancer developed a salivary gland neoplasm after completion of treatment.
  • These patients were initially treated for a variety of childhood cancers with a combination of radiation and chemotherapy.
  • The pathology of the salivary gland tumors were mucoepidermoid carcinoma (10), adenoid cystic carcinoma (1) , and pleomorphic adenoma (1).
  • CONCLUSION: Radiation and chemotherapy used to treat patients with childhood malignancies increases the risk of developing a second neoplasm of salivary gland origin.
  • The majority of these neoplasms are malignant; mucoepidermoid carcinoma occurs most frequently.
  • The treatment of these tumors includes surgical excision of the primary, with neck dissection in patients with clinical evidence of nodal metastasis, and postoperative radiation added for pathologies with adverse features.
  • [MeSH-major] Neoplasms, Second Primary / diagnosis. Salivary Gland Neoplasms / diagnosis. Survivors
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / surgery. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Male. Neck Dissection. Neoplasms / drug therapy. Neoplasms / radiotherapy. Radiotherapy, Adjuvant. Registries. Retrospective Studies. Risk Factors


26. Lüdike A, Knolle J, Schön R, Hinze P, Hofmann HS, Schreiber J: [Primary pulmonary rhabdomyosarcoma as a rare differential diagnosis of small cell lung cancer]. Pneumologie; 2005 Jul;59(7):456-60
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  • [Title] [Primary pulmonary rhabdomyosarcoma as a rare differential diagnosis of small cell lung cancer].
  • Primary pulmonary rhabdomyosarcoma is a rare entity and the histological differential diagnosis can be difficult.
  • Histological examination revealed a typical small cell carcinoma and histological examination of biopsies obtained from a tumor in the left upper lobe of the lung was compatible with a small cell carcinoma.
  • Despite chemotherapy there was a progressive tumor growth.
  • Bronchial biopsies again showed a small cell tumor, although immunohistochemistry proved it to be a pleomorphic rhabdomyosarcoma.
  • Due to the progressive tumor growth with necrosis and superinfection and a lack of further metastases lobectomy of the left upper lobe was performed, complicated by postoperative pleural empyema, limiting the possibilities of adjuvant therapy.
  • Laminectomy and extirpation of the spinal metastases, local radiotherapy and chemotherapy with iphosphamide and doxorubicine led to partial remission and clinical improvement for few months only.
  • The patient died from metastatic primary rhabdomyosarcoma of the lung.
  • This rare tumor mimicked small cell lung cancer.
  • Appraisal of the atypical clinical course and a close dialogue between pathologists and clinicians enabled the correct diagnosis.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Lung Neoplasms / pathology. Rhabdomyosarcoma / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Diagnosis, Differential. Fatal Outcome. Female. Humans. Recurrence

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  • (PMID = 16047279.001).
  • [ISSN] 0934-8387
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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27. Michael H, Lucia J, Foster RS, Ulbright TM: The pathology of late recurrence of testicular germ cell tumors. Am J Surg Pathol; 2000 Feb;24(2):257-73
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  • A total of 91 men had histologically documented late recurrences of testicular germ cell tumors characterized by a complete response to treatment with a subsequent disease-free interval of at least 2 years and no evidence of a second primary lesion.
  • Ninety percent of the patients for whom information was available received chemotherapy shortly after their initial diagnosis of testicular germ cell tumors; most of the other patients were known to have stage I disease initially.
  • Thus, teratoma was the most common type of neoplasm in late recurrences.
  • Excluding teratoma coexisting with other types of neoplasms, yolk sac tumor was the most frequent type of tumor in patients with late recurrence.
  • It occurred in 47% of patients, either alone or with teratoma, another nonteratomatous germ cell tumor type, or a "nongerm cell malignant tumor."
  • Unusual types of yolk sac tumor, including glandular, parietal, clear cell, and pleomorphic patterns, were seen frequently in late recurrences and often raised differential diagnostic problems with "nongerm cell" carcinomas.
  • A smaller number of late recurrences consisted of other types of neoplasms.
  • Most of these nonteratomatous germ cell tumors other than yolk sac tumor were embryonal carcinoma, although rarely seminoma and choriocarcinoma were encountered.
  • "Nongerm cell malignant tumors," including both sarcomas and carcinomas of various types, occurred in 23% of late-recurrence patients, either alone or with a nonteratomatous germ cell tumor.
  • Late recurrences were seen in many different sites in these patients, including the retroperitoneum, abdomen, pelvis, liver, mediastinum, lung, bone (femur, vertebra, and rib), lymph nodes outside the retroperitoneum and mediastinum (supraclavicular, neck, and axillary regions), scrotum and inguinal regions, adrenal gland, chest wall, and buttocks.
  • Patients whose late recurrences consisted of pure "nongerm cell malignant tumor" or pure germ cell tumor (yolk sac tumor or other types) had a much worse prognosis: Only 36% to 37% were alive with no evidence of disease.
  • Patients with two different types of nonteratomatous malignancies in their late recurrences had a dismal clinical course: Only 17% with both yolk sac tumor and other nonteratomatous germ cell tumor had no evidence of disease, whereas no patient with both nonteratomatous germ cell tumor and "nongerm cell malignant tumor" was disease free.
  • Furthermore, late recurrence is not likely to respond to chemotherapy and is best treated by surgical excision when possible.
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Embryonal / complications. Carcinoma, Embryonal / pathology. Carcinoma, Embryonal / therapy. Choriocarcinoma / complications. Choriocarcinoma / pathology. Choriocarcinoma / therapy. Endodermal Sinus Tumor / complications. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / therapy. Fluorescent Antibody Technique, Direct. Humans. Male. Neoplasm Staging. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Sarcoma / complications. Sarcoma / pathology. Sarcoma / therapy. Seminoma / complications. Seminoma / pathology. Seminoma / therapy. Teratoma / complications. Teratoma / pathology. Teratoma / therapy

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  • (PMID = 10680894.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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28. Pogodzinski MS, Sabri AN, Lewis JE, Olsen KD: Retrospective study and review of polymorphous low-grade adenocarcinoma. Laryngoscope; 2006 Dec;116(12):2145-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fifteen patients had their initial treatment at our institution, and four patients presented with a recurrent tumor.
  • One patient had regional nodal disease 20 years after the initial procedure, and another had lung metastasis.
  • No patients received chemotherapy.
  • The most common initial diagnoses were polymorphous low-grade adenocarcinoma, adenoid cystic carcinoma, and pleomorphic adenoma.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Salivary Glands, Minor






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