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1. Ang TL, Ng VW, Fock KM, Teo EK, Chong CK: Diagnosis of a metastatic phyllodes tumor of the pancreas using EUS-FNA. JOP; 2007;8(1):35-8
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  • [Title] Diagnosis of a metastatic phyllodes tumor of the pancreas using EUS-FNA.
  • CONTEXT: Phyllodes tumors are rare fibro-epithelial lesions which make up less than 1% of all breast neoplasms.
  • Until now, there have been no published reports on the use of EUS-FNA to diagnose recurrent phyllodes tumors metastatic to the pancreas.
  • She had a past history of a left breast phyllodes tumor treated with mastectomy.
  • The diagnostic dilemma was whether this was a case of primary pancreatic cancer or a recurrent phyllodes tumor presenting as a pancreatic metastasis.
  • EUS-FNA of the mass was performed and it revealed a metastatic phyllodes tumor.
  • The patient was treated with palliative biliary stenting and was referred for palliative chemotherapy.
  • CONCLUSION: This is the first report of a recurrent phyllodes tumor metastatic to the pancreas diagnosed using EUS-FNA.
  • [MeSH-major] Breast Neoplasms / pathology. Pancreatic Neoplasms / secondary. Phyllodes Tumor / secondary


2. Parker SJ, Harries SA: Phyllodes tumours. Postgrad Med J; 2001 Jul;77(909):428-35
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  • [Title] Phyllodes tumours.
  • Phyllodes tumours are rare fibroepithelial lesions that account for less than 1% of all breast neoplasms.
  • With the non-operative management of fibroadenomas widely adopted, the importance of phyllodes tumours today lies in the need to differentiate them from other benign breast lesions.
  • All breast lumps should be triple assessed and the diagnosis of a phyllodes tumour considered in women, particularly over the age of 35 years, who present with a rapidly growing "benign" breast lump.
  • Treatment can be by either wide excision or mastectomy provided histologically clear specimen margins are ensured.
  • Approximately 20% of patients with malignant phyllodes tumours develop distant metastases.
  • The role of chemotherapy, radiotherapy, and hormonal manipulation in both the adjuvant and palliative settings remain to be defined.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 11423590.001).
  • [ISSN] 0032-5473
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 111
  • [Other-IDs] NLM/ PMC1760996
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3. Grenier J, Delbaldo C, Zelek L, Piedbois P: [Phyllodes tumors and breast sarcomas: a review]. Bull Cancer; 2010 Oct;97(10):1197-207
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  • [Title] [Phyllodes tumors and breast sarcomas: a review].
  • [Transliterated title] Tumeurs phyllodes et sarcomes du sein: mise au point.
  • Phyllodes tumors and sarcomas of the breast are non-epithelial tumors of the breast.
  • Phyllodes tumors are benign tumors, tumors of intermediate malignancy or malignant tumors.
  • The differential diagnosis with a very proliferant fibroadenoma may be difficult.
  • Histological sub-type, type of surgery (definitive or not) and stromal proliferation determine the prognosis.
  • Surgery (often radical) is the standard treatment.
  • Radiotherapy is recommended in case of high-grade tumor and after conservativetreatment.
  • Breast sarcomas are even rarer.
  • All histological types exist with a predominance of histiofibrocytome type tumors.
  • Grade, involved margins and sometimes tumor necrosis are major prognostics factors.
  • Among the various sub-types, angiosarcoma is characterized by a high risk of occurrence in irradiated fields and by a poor prognosis with a high risk of lung metastases.
  • The treatment is mostly based on mastectomy without lymph node dissection given the exceptional flooding axillary.
  • In some situations, a conservative treatment can be discussed, based on tumor size, grade and volume of the breast.
  • Systemic chemotherapy is not a standard but should be discussed in the forms at high risk of relapse (like angiosarcoma).
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology. Sarcoma / pathology
  • [MeSH-minor] Female. Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Hemangiosarcoma / therapy. Humans. Neoplasm Recurrence, Local. Prognosis

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  • (PMID = 20855241.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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4. Sugie T, Takeuchi E, Kunishima F, Yotsumoto F, Kono Y: A case of ductal carcinoma with squamous differentiation in malignant phyllodes tumor. Breast Cancer; 2007;14(3):327-32
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  • [Title] A case of ductal carcinoma with squamous differentiation in malignant phyllodes tumor.
  • Carcinoma derived from the lining epithelial cells in malignant phyllodes tumor is a rare neoplasm of the breast and belongs to the category of carcinosarcoma.
  • We report a case of ductal carcinoma with squamous differentiation arising in malignant phyllodes tumor.
  • A 54-year-old woman was admitted with a rapidly enlarging left breast mass.
  • A breast tumor with a diameter of 6 cm was located mainly in the left outer area of the breast.
  • Mammography revealed a high-density mass with an irregular margin and ultrasound showed a cystic tumor.
  • A pathological diagnosis of ductal carcinoma with squamous differentiation was made by fine needle aspiration and a core needle biopsy.
  • She underwent neoadjuvant chemotherapy followed by a modified radical mastectomy with a skin flap.
  • Histopathological examination revealed that the invasive ductal carcinoma with squamous differentiation originated from the lining epithelial cells in malignant phyllodes tumor and that there was no transition area between the carcinomatous and the sarcomatous component.
  • She experienced lung and facial bone metastases, microscopic features of which were consistent with the sarcomatous component of the original breast carcinosarcoma.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Neoplasms, Multiple Primary / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 17690514.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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5. Korula A, Varghese J, Thomas M, Vyas F, Korula A: Malignant phyllodes tumour with intraductal and invasive carcinoma and lymph node metastasis. Singapore Med J; 2008 Nov;49(11):e318-21
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  • [Title] Malignant phyllodes tumour with intraductal and invasive carcinoma and lymph node metastasis.
  • Phyllodes tumours constitute 2-3 percent of fibroepithelial breast tumours, with a 1-2 percent rate of malignancy.
  • Carcinoma in a phyllodes tumour is distinctly uncommon, but has been known to occur in benign phyllodes tumours.
  • We describe a 51-year-old woman with a malignant phyllodes tumour with foci of intraductal carcinoma within the tumour and adjacent breast tissue.
  • Though the carcinoma was found to be invasive based on the presence of carcinomatous lymph node metastasis, extensive sampling did not yield an invasive component within the breast, probably because of the marked stromal overgrowth of the phyllodes.
  • A malignant phyllodes tumour with foci of intraductal carcinoma and axillary lymph node metastases was diagnosed rather than carcinosarcoma.
  • Chemotherapy and irradiation were included in the postoperative management.
  • Coexistence of phyllodes tumour and carcinoma is rare, and extensive sampling may be necessary to find the foci of carcinoma within an extensive and obviously malignant stromal overgrowth.
  • There is little consensus on the treatment and prognosis in these cases, and it is recommended that treatment be tailored to individual patients, based on the presence of invasion, lymph node metastasis and/or distant metastasis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma / diagnosis. Carcinoma / pathology. Phyllodes Tumor / diagnosis. Phyllodes Tumor / pathology
  • [MeSH-minor] Breast / pathology. Breast / surgery. Female. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymphatic Metastasis. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Treatment Outcome

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  • (PMID = 19037540.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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6. Morales-Vásquez F, Gonzalez-Angulo AM, Broglio K, Lopez-Basave HN, Gallardo D, Hortobagyi GN, De La Garza JG: Adjuvant chemotherapy with doxorubicin and dacarbazine has no effect in recurrence-free survival of malignant phyllodes tumors of the breast. Breast J; 2007 Nov-Dec;13(6):551-6
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  • [Title] Adjuvant chemotherapy with doxorubicin and dacarbazine has no effect in recurrence-free survival of malignant phyllodes tumors of the breast.
  • The purpose of this study was to evaluate the role of adjuvant chemotherapy in malignant phyllodes tumors of the breast treated at the Instituto Nacional de Cancerología of Mexico.
  • Twenty-eight patients with malignant phyllodes tumors of the breast enrolled in a observational study from January 1993 to December 2003 to receive four cycles of adjuvant chemotherapy with doxorubicin 65 mg/m(2) over 48 hours intravenous infusion and dacarbazine 960 mg/m(2) over 48 hours intravenous infusion (n = 17) versus observation (n = 11).
  • The median tumor size was 13 cm (range, 3-30 cm), and 46% of the tumors were in the left breast.
  • The 5 year RFS rate was 58% (95% CI = 36% and 92%) for the patients who received adjuvant therapy and 86% (95% CI = 63% and 100%) for the patients who did not (p = 0.17).
  • Adjuvant chemotherapy with doxorubicin and dacarbazine did not affect patient survival.
  • Future studies to identify relevant molecular targets should be implemented in order to define effective therapies for phyllodes tumors of the breast.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Breast Neoplasms / drug therapy. Dacarbazine / administration & dosage. Doxorubicin / administration & dosage. Phyllodes Tumor / drug therapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents, Alkylating / administration & dosage. Chemotherapy, Adjuvant. Disease-Free Survival. Dose-Response Relationship, Drug. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neoplasm Staging. Treatment Outcome

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  • (PMID = 17983394.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin
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7. Shabbir J, O'Sullivan JB, Mahmood S, Byrnes G: Phyllodes tumor of breast. J Coll Physicians Surg Pak; 2003 Mar;13(3):170-1
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  • [Title] Phyllodes tumor of breast.
  • Phyllodes tumors account for 0.3%-0.5% of all the breast tumors.
  • Surgery is the mainstay of treatment as there is no proven benefit of adjuvant chemotherapy or radiotherapy.
  • We are presenting a case of 42 years old female with benign phyllodes tumor and a brief review of literature on the subject.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / surgery. Phyllodes Tumor / pathology. Phyllodes Tumor / surgery
  • [MeSH-minor] Adult. Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Mastectomy, Segmental / methods. Rare Diseases. Risk Assessment. Treatment Outcome

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  • (PMID = 12689541.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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8. Bouhafa T, Masbah O, Bekkouch I, Afqir S, Mellas N, Ismaili N, Hassouni K, Kebdani T, Jalil A, Benjaafar N, Errihani H, Elgueddari B: [Phyllodes tumors of the breast: analysis of 53 patients]. Cancer Radiother; 2009 Apr;13(2):85-91
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  • [Title] [Phyllodes tumors of the breast: analysis of 53 patients].
  • [Transliterated title] Tumeurs phyllodes du sein à propos de 53 cas.
  • PURPOSE: Phyllode tumors of the breast are fibroepithelial tumors similar to fibroadenomas but with a predominant conjunctive tissue component.
  • These are composed of a connective tissue stroma and epithelial elements.
  • They are rare with an incidence of 0.3-0.9% of all breast neoplasms.
  • The present study demonstrates the recent experiences in diagnosis, therapeutical management and clinical follow-up of this disease.
  • Median age was 37.2 years (15-67), tumor size was 1-30cm (median 10.25cm).
  • The histological diagnosis was based on the biopsy in (7.8%) cases and extemporany in 22% cases, distant metastasis occurred in two patients; the treatment consisted of a surgery.
  • CONCLUSION: The confrontation of our results to the data of the international literature shows that the diagnosis of the phyllodes tumours is histological.
  • The basis of the treatment is surgery.
  • The adjuvant radiotherapy is very important in patients at high risk for local recurrence; chemotherapy has a badly defined place.
  • The prognostic is based on the histological characters of the tissue conjunctive component of these tumours.
  • [MeSH-major] Breast Neoplasms / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / secondary. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Mastectomy. Middle Aged. Neoplasm Recurrence, Local / therapy. Radiotherapy, Adjuvant. Retrospective Studies. Young Adult

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  • (PMID = 19119040.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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9. Khan SA, Badve S: Phyllodes tumors of the breast. Curr Treat Options Oncol; 2001 Apr;2(2):139-47
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  • [Title] Phyllodes tumors of the breast.
  • Phyllodes tumor is a rare fibroepithelial neoplasm of the breast with a very variable, but usually benign, course.
  • Formerly known as cystosarcoma phyllodes, the designation "phyllodes tumor" with appropriate qualification regarding malignant potential based on pathologic features is now the agreed-upon term.
  • The most important diagnostic distinction is from fibroadenoma--phyllodes tumors require complete excision with free margins even when pathologic features suggest benignity because of a proclivity to local recurrence.
  • The most important component of therapy is wide surgical excision, and mastectomy is necessary only when free margins cannot be achieved without it.
  • The role of radiation therapy and chemotherapy is not established and has not been studied in randomized trials due to the rarity of the tumor.
  • At present, there is no consensus that patients with high-grade phyllodes tumors of the breast will benefit from either of these modalities.
  • [MeSH-major] Breast Neoplasms / surgery. Phyllodes Tumor / surgery
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cisplatin / administration & dosage. Disease-Free Survival. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Mastectomy. Mastectomy, Segmental. Practice Guidelines as Topic. Prognosis

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  • (PMID = 12057132.001).
  • [ISSN] 1527-2729
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
  • [Number-of-references] 32
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10. Tan EY, Tan PH, Yong WS, Wong HB, Ho GH, Yeo AW, Wong CY: Recurrent phyllodes tumours of the breast: pathological features and clinical implications. ANZ J Surg; 2006 Jun;76(6):476-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent phyllodes tumours of the breast: pathological features and clinical implications.
  • BACKGROUND: Phyllodes tumours (PT) of the breast are fibro-epithelial neoplasms that are known to recur locally in up to 19% of patients.
  • It is still debatable as to whether it is necessary to subject the patient to repeat surgery to obtain pathologically negative margins after a diagnosis of a benign or borderline PT is made.
  • Malignant tumours can metastasize through the haematogenous route and metastases are associated with a poor prognosis as they are poorly responsive to conventional chemotherapy.
  • Data, including age at the time of diagnosis, clinical presentation, histological features, type of surgery carried out, clinical progression and characteristics of locally recurrent disease, were analysed.
  • Comparisons were made between those with benign, borderline and malignant tumours, as well as between those who developed a malignant recurrence and those who did not.
  • RESULTS: The mean age at the time of diagnosis was 39.6 +/- 7.4 years and the mean tumour size was 6.0 +/- 5.1 cm.
  • Tumour grade did not influence the tumour size, the adequacy of surgical margins or the time interval to local recurrence or the number of recurrences.
  • The majority of recurrent tumours were histologically similar to the initial tumour; however, seven patients (19%) developed a malignant recurrence from an initially benign or borderline tumour.
  • Distant metastasis developed only in patients with malignant tumours and accounted for all three mortalities in the study.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Phyllodes Tumor / pathology
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Mastectomy. Middle Aged. Reoperation. Retrospective Studies. Time Factors. Treatment Outcome

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  • [ErratumIn] ANZ J Surg. 2006 Oct;76(10):956. Hoon, Tan Puay [corrected to Tan, Puay Hoon]; Hui, Ho G [corrected to Ho, Gay Hui]
  • (PMID = 16768772.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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11. Pandey M, Mathew A, Abraham EK, Rajan B: Primary sarcoma of the breast. J Surg Oncol; 2004 Sep 1;87(3):121-5
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  • [Title] Primary sarcoma of the breast.
  • BACKGROUND AND OBJECTIVES: Primary sarcoma occurring in breast is rare and comprises 0.5-1% of all breast neoplasm.
  • Majority of the series include both stromal and cystosarcoma phyllodes, only a few hundred cases of sarcomas other then cystosarcoma are reported.
  • PATIENTS AND METHODS: We carried out a retrospective analysis of 19 patients with primary sarcoma of the breast treated between 1982 and 2002.
  • There were eight cases of angiosarcoma, four cases of spindle cell sarcoma, two each of pleomorphic sarcoma and stromal sarcoma, and one each of malignant fibrous histiocytoma, embryonal rhabdomyosarcoma, and sarcoma (NOS).
  • Two patients received chemotherapy.
  • After a mean follow-up time of 34.5 months (median 25 months), eight patients failed.
  • Failure was local in five, opposite breast in one, and both local and distant in two.
  • CONCLUSIONS: Primary sarcomas of the breast are aggressive tumors.
  • Surgical treatment should consist of at least simple mastectomy.
  • [MeSH-major] Breast Neoplasms / surgery. Mastectomy. Sarcoma / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Child. Disease-Free Survival. Female. Hemangiosarcoma / drug therapy. Hemangiosarcoma / radiotherapy. Hemangiosarcoma / surgery. Histiocytoma, Benign Fibrous / drug therapy. Histiocytoma, Benign Fibrous / radiotherapy. Histiocytoma, Benign Fibrous / surgery. Humans. Middle Aged. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies. Rhabdomyosarcoma / drug therapy. Rhabdomyosarcoma / radiotherapy. Rhabdomyosarcoma / surgery. Survival Analysis

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  • [Copyright] Copyright 2004 Wiley-Liss, Inc.
  • [CommentIn] J Surg Oncol. 2004 Oct 1;88(1):50-1 [15384090.001]
  • (PMID = 15334638.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Guerrero MA, Ballard BR, Grau AM: Malignant phyllodes tumor of the breast: review of the literature and case report of stromal overgrowth. Surg Oncol; 2003 Jul;12(1):27-37
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  • [Title] Malignant phyllodes tumor of the breast: review of the literature and case report of stromal overgrowth.
  • Cystosarcoma phyllodes constitutes only 0.3-0.9% of all breast tumors.
  • The term "sarcoma" was initially used because of its fleshy appearance, a more modern term is Phyllodes tumor (PT).
  • The microscopic appearance of PT is that of epithelial elements and connective tissue stroma.
  • Wide local excision with 2 cm margins is the treatment of choice.
  • There is no proven benefit of radiation or chemotherapy, although radiotherapy may be useful in selected cases.
  • We present a case of a sarcomatous overgrowth in a malignant phyllodes tumor involving multiple histologic types.
  • [MeSH-major] Breast Neoplasms / surgery. Phyllodes Tumor / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Treatment Outcome

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  • (PMID = 12689668.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 56
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13. Pricop M, Ioanid N, Muscă S, Strat L, Slătineanu S: [Phyllodes tumor. The experience of the 4th Obstetrics-Gynecology Department]. Rev Med Chir Soc Med Nat Iasi; 2002 Jan-Mar;106(1):53-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Phyllodes tumor. The experience of the 4th Obstetrics-Gynecology Department].
  • Between the 1st of January 1994 and the 1st of November 2001 587 operations have been performed as treatment of breast tumors in the IVth Obstetrics and Gynecology Department.
  • The phyllodes tumor has been diagnosed in 11 cases (1.8% of the benign breast masses).
  • The most common aspect is a round, hard, unpainful breast mass.
  • The surgical treatment is mandatory but radiotherapy, chemotherapy and endocrine treatment protocols have been brought up.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor
  • [MeSH-minor] Adult. Female. Humans. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 12635360.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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14. Confavreux C, Lurkin A, Mitton N, Blondet R, Saba C, Ranchère D, Sunyach MP, Thiesse P, Biron P, Blay JY, Ray-Coquard I: Sarcomas and malignant phyllodes tumours of the breast--a retrospective study. Eur J Cancer; 2006 Nov;42(16):2715-21
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  • [Title] Sarcomas and malignant phyllodes tumours of the breast--a retrospective study.
  • BACKGROUND: Although most breast cancers are adenocarcinomas of the mammary gland, primary breast sarcomas may also arise from mammary gland mesenchymal tissue.
  • The annual incidence of primary breast sarcoma is low and has been estimated at 45 new cases per 10 million women.
  • Phyllodes tumours represent a specific subset of these breast soft tissue tumours.
  • They are composed of a connective tissue stroma and epithelial elements.
  • Pathological presentation ranges from grade I to malignant phyllodes tumours (grade III) where the stromal component clearly exhibits a sarcoma pattern.
  • SAPHYR aims to describe the characteristics of primary breast sarcomas and to define potential survival factors to be evaluated in future prospective studies.
  • No survival difference was found between malignant phyllodes (grade III) and other primary breast sarcomas (angiosarcomas excluded).
  • Histology revealed three significantly (p=0.0003) different prognostic groups: phyllodes grade I and II (DFS=57%), angiosarcomas (DFS=7%) and phyllodes grade III and other primary breast sarcomas (DFS=45%).
  • DISCUSSION: Phyllodes tumours and primary breast sarcomas are totally different from epithelial breast cancers and should be considered as a distinct group of rare tumours.
  • The first goal of treatment is to achieve negative margins (R0).
  • We propose to treat the patients according to the clinical practice guidelines in use for soft tissue sarcomas and address them to a reference centre for sarcoma.
  • Treating rare tumours in the same place should permit us to standardise pathological data and to include patients into multicentric radiotherapy or chemotherapy protocols to improve overall survival.
  • [MeSH-major] Breast Neoplasms. Phyllodes Tumor. Sarcoma
  • [MeSH-minor] Adult. Disease-Free Survival. Female. Humans. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis

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  • (PMID = 17023158.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Soumarová R, Seneklová Z, Horová H, Vojkovská H, Horová I, Budíková M, Růzicková J, Jezková B: Retrospective analysis of 25 women with malignant cystosarcoma phyllodes--treatment results. Arch Gynecol Obstet; 2004 May;269(4):278-81
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  • [Title] Retrospective analysis of 25 women with malignant cystosarcoma phyllodes--treatment results.
  • PURPOSE: Mastectomy without axillary dissection should be the standard treatment in patients with malignant form of cystosarcoma phyllodes.
  • The role of postoperative radiotherapy and chemotherapy remains to be fully established.
  • We evaluate treatment results in a group of patients with cystosarcoma phyllodes (CP) treated at our Institute.
  • PATIENTS AND METHODS: In this report we analyze treatment outcome in 25 patients with malignant cystosarcoma phyllodes treated at Masaryk Memorial Cancer Institute between 1970 and 1995.
  • Mean tumor size was 10 cm in diameter.
  • Subsequently, 17 patients (68%) received radiotherapy on the breast or chest wall.
  • Time to local relapse after surgery was 4-11 months.
  • CONCLUSION: A specific protocol for the treatment of cystosarcoma phyllodes is missing, probably due to rarity of the disease.
  • The treatment of local recurrent disease remains unsuccessful in most CP patients.
  • [MeSH-major] Breast Neoplasms / epidemiology. Neoplasm Recurrence, Local / epidemiology. Phyllodes Tumor / epidemiology
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Czech Republic / epidemiology. Disease-Free Survival. Female. Humans. Medical Records. Middle Aged. Retrospective Studies. Survival Analysis

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  • (PMID = 15205980.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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16. Udelnow A, Leinung S, Dannenberg C, Trantakis Ch, Schober R, Schönfelder M, Würl P: [A giant malignant tumour of the skull-Case report and differential diagnosis]. Zentralbl Chir; 2002 Mar;127(3):243-5
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  • [Title] [A giant malignant tumour of the skull-Case report and differential diagnosis].
  • [Transliterated title] Ein gigantischer maligner Tumor der Kalotte - Fallbericht und Differentialdiagnose.
  • The case of a 72-year-old woman with a high-partially located tumor grown within a half year to a magnitude of 8.5 x 11 x 11 cm is reported.
  • The patient remembered a mastectomy and axillary lymphadenectomy followed by chemotherapy and radiation 8 years ago.
  • Therefore we assumed a skeletal metastasis of a breast cancer.
  • Searching for the pathohistological evaluation of the former breast tumor, a cystosarcoma phylloides malignum could be found out.
  • The tumor described here can be identified as a metastasis of this rare neoplasm.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / secondary. Skull Neoplasms / secondary
  • [MeSH-minor] Aged. Craniotomy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Parietal Lobe / pathology. Parietal Lobe / surgery. Tomography, X-Ray Computed

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  • (PMID = 11935491.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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17. Khaldi L, Athanasiou ET, Hadjitheofilou CT: Primary mammary osteogenic sarcoma. Histol Histopathol; 2007 04;22(4):373-7
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  • A 78 year-old female patient underwent a total mastectomy with axillary lymph node dissection for a primary breast osteosarcoma.
  • Microscopically the tumor was identical to grade II skeletal osteosarcoma.
  • The diagnosis of this tumor fulfills certain clinicopathological criteria.
  • Mammary osteosarcoma is usually developed in phyllodes tumors or carcinosarcomas of the breast as a result of metaplasia of the epithelial component.
  • This rare tumor of the breast is occasionally associated with prior radiation therapy or well documented trauma.
  • Mammary osteosarcoma is a biologically aggressive neoplasm with a 38% five-year survival rate.
  • Surgical resection is the most effective therapy to date.
  • Adjuvant treatment -chemotherapy or radiotherapy- has shown no clear benefit.
  • [MeSH-major] Breast Neoplasms / pathology. Osteosarcoma / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Disease-Free Survival. Female. Fluorescent Antibody Technique, Indirect. Humans. In Situ Hybridization, Fluorescence. Lymph Node Excision. Mastectomy


18. Fajdić J, Gotovac N, Hrgović Z, Kristek J, Horvat V, Kaufmann M: Phyllodes tumors of the breast diagnostic and therapeutic dilemmas. Onkologie; 2007 Mar;30(3):113-8
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  • [Title] Phyllodes tumors of the breast diagnostic and therapeutic dilemmas.
  • BACKGROUND: This article compares experiences in the diagnosis and treatment of phyllodes tumors from 2 regional institutions with the relevant literature.
  • PATIENTS AND METHODS: From 1991 to 2005, 2,848 breast cancer patients were treated in our institutions, 36 (1.44%) for phyllodes tumors.
  • The average tumor size was 5.1 cm (range 1.4-19.6).
  • Wide excision with tumor-free margins was carried out in 29 (80.5%) cases and mastectomy in 7 (19.4%) cases.
  • RESULTS: Histology showed the phyllodes tumors to be benign in 27 (75.0%), malignant in 6 (16.6%), and borderline in 3 (8.3%) cases.
  • In this period, recurrences of 3 (8.3%) malignant and 2 (5.6%) benign phyllodes tumors were diagnosed and treated.
  • The steroid receptor status was of no prognostic value in our patients, and chemotherapy was used in only 1 (2.7%) patient.
  • CONCLUSION: Our study shows that tumor size, margin infiltration, mitotic activity and degree of cellular atypia are important prognostic factors.
  • Although wide local excision is usually the treatment of choice, tumor recurrence is common.
  • Axillary lymphadenectomy in malignant phyllodes tumors is, in our opinion, still controversial.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Breast / pathology. Diagnosis, Differential. Female. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Mammography. Mastectomy. Mastectomy, Segmental. Middle Aged. Mitotic Index. Necrosis. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Prognosis. Reoperation. Survival Rate

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  • (PMID = 17341897.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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19. Ueyama Y, Abe Y, Ohnishi Y, Sawa N, Hatanaka H, Handa A, Tokuda Y, Yamazaki H, Kijima H, Tamaoki N, Nakamura M: In vivo chemosensitivity of human malignant cystosarcoma phyllodes xenografts. Oncol Rep; 2000 Mar-Apr;7(2):257-60
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  • [Title] In vivo chemosensitivity of human malignant cystosarcoma phyllodes xenografts.
  • Malignant cystosarcoma phyllodes (MCSP) is a rare breast tumor.
  • Chemotherapeutic regimens for treatment of MCSP have not been established.
  • We studied the chemosensitivity of these two MCSP tumor xenografts to anticancer drugs in vivo.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Breast Neoplasms / drug therapy. Cyclophosphamide / pharmacology. Doxorubicin / pharmacology. Drug Screening Assays, Antitumor. Phyllodes Tumor / drug therapy. Vincristine / pharmacology
  • [MeSH-minor] Animals. Drug Resistance, Neoplasm. Female. Humans. Mice. Mice, Nude. Neoplasm Transplantation. P-Glycoprotein / biosynthesis. Transplantation, Heterologous

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  • (PMID = 10671667.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] GREECE
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / P-Glycoprotein; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide
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20. Chen WH, Cheng SP, Tzen CY, Yang TL, Jeng KS, Liu CL, Liu TP: Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases. J Surg Oncol; 2005 Sep 1;91(3):185-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases.
  • BACKGROUND AND OBJECTIVES: Phyllodes tumors (PTs) are uncommon biphasic breast tumors that usually occur in adult females.
  • No one morphologic finding is reliable in predicting the clinical behavior of the tumor.
  • Clinical data analyzed included age, presenting symptoms and signs, tumor size, location, type of surgery, time to recurrence, and metastasis.
  • The majority of tumors were found in the upper outer quadrant (46.0%), with an equal propensity to occur in either breast (48.8% vs. 50.0%).
  • The initial diagnosis of all 19 recurrent tumors were benign.
  • Stromal cellularity, stromal overgrowth, stromal atypia, mitotic activity, tumor margin, and heterologous stromal elements were significantly correlated with metastases (P = 0.032, 0.00008, 0.000002, 0.004, 0.005, and 0.046, respectively).
  • Mammography and breast echo were not reliable for differentiating PTs from fibroadenomas (6.9% vs. 37.9% and 3.3% vs. 45%, respectively).
  • The role of adjuvant radiotherapy and chemotherapy remains to be defined.
  • The reasons for these procedures included a diagnosis of malignancy on frozen section or because the tumors were so large, they were assumed to be carcinomas.
  • Fifteen patients in our series had tumors with infiltrating tumor margin, severe stromal overgrowth, atypia, and cellularity.
  • CONCLUSIONS: Wide excision with a clear margin may be the preferable initial therapy, even for malignant PTs.
  • Patients have tumors with infiltrating tumor margin, severe stromal overgrowth, atypia, and cellularity are at high risk for metastases.
  • [MeSH-major] Breast Neoplasms / surgery. Mastectomy / methods. Phyllodes Tumor / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Mastectomy, Segmental. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local / epidemiology. Retrospective Studies. Taiwan / epidemiology. Treatment Outcome

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16118768.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Sabban F, Collinet P, Lucot JP, Boman F, Leroy JL, Vinatier D: [Phyllodes tumor of the breast: analysis of 8 patients]. J Gynecol Obstet Biol Reprod (Paris); 2005 May;34(3 Pt 1):252-6
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  • [Title] [Phyllodes tumor of the breast: analysis of 8 patients].
  • [Transliterated title] Tumeurs phyllodes du sein: à propose de 8 patientes.
  • INTRODUCTION: Phyllodes tumors of breast are rare and usually benign.
  • Histological confirmation on the operative specimen is required to establish the diagnosis and histological pronostic of phyllode tumors.
  • MATERIALS AND METHODS: We reviewed 8 cases of phyllodes tumors and the literature to report the circumstances of occurrence of these tumors, and their specific clinical diagnosis, therapeutic, prognostic features.
  • The mean age at diagnosis was 33.4 years.
  • Mean tumor size was 3.75 cm.
  • Imaging findings were helpful for diagnosis.
  • Aspiration cytology demonstrated the phyllode tumor in 43% of patients.
  • One patient underwent mastectomy and radiotherapy and chemotherapy.
  • [MeSH-major] Breast Neoplasms / diagnosis. Phyllodes Tumor / diagnosis
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Female. Humans. Mastectomy. Mastectomy, Segmental. Middle Aged. Radiotherapy

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  • (PMID = 16012385.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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22. Di Benedetto G, Sperti V, Grassetti L, Forlini W, Scalise A, Bertani A: Temporary remission of a multirecurrent cystosarcoma phyllodes of the breast by using continuous chemotherapy. Plast Reconstr Surg; 2009 Feb;123(2):72e-73e
Hazardous Substances Data Bank. IFOSFAMIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temporary remission of a multirecurrent cystosarcoma phyllodes of the breast by using continuous chemotherapy.
  • [MeSH-major] Antineoplastic Agents, Alkylating / administration & dosage. Breast Neoplasms / drug therapy. Ifosfamide / administration & dosage. Neoplasm Recurrence, Local / drug therapy. Phyllodes Tumor / drug therapy
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Mesna / administration & dosage. Middle Aged. Protective Agents / administration & dosage. Remission Induction

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  • (PMID = 19182582.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Protective Agents; NR7O1405Q9 / Mesna; UM20QQM95Y / Ifosfamide
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