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Items 1 to 18 of about 18
1. Ammerlaan AC, Houben MP, Tijssen CC, Wesseling P, Hulsebos TJ: Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation. Childs Nerv Syst; 2008 Jul;24(7):855-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Secondary meningioma in a long-term survivor of atypical teratoid/rhabdoid tumour with a germline INI1 mutation.
  • OBJECTIVE: We report on a patient who developed a meningioma more than two decades after removal at a young age of an atypical teratoid/rhabdoid tumour (AT/RT), which was due to a germline INI1 mutation, and radio- and chemotherapy.
  • MATERIALS AND METHODS: We present genetic evidence that the meningioma is not a recurrence or metastasis of the AT/RT and not due to the INI1 mutation, but is a radiation-induced tumour.
  • CONCLUSION: This is the first case illustrating that improved survival of young patients with an AT/RT after aggressive treatment may be gained at the cost of an increased risk for the development of radiation-induced, non-INI1-related tumours.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / genetics. DNA-Binding Proteins / genetics. Meningioma / secondary. Mutation / genetics. Rhabdoid Tumor / genetics. Transcription Factors / genetics

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  • (PMID = 18236049.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2413122
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2. Muscal JA, Jones JY, Paulino AC, Bertuch AA, Su J, Woo SY, Mahoney DH Jr, Chintagumpala M: Changes mimicking new leptomeningeal disease after intensity-modulated radiotherapy for medulloblastoma. Int J Radiat Oncol Biol Phys; 2009 Jan 1;73(1):214-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Acute and late changes in magnetic resonance imaging of the pediatric brain have been described after radiotherapy (RT).
  • METHODS AND MATERIALS: We performed a retrospective review of 53 consecutive children with medulloblastoma who were treated with craniospinal RT followed by IMRT to the posterior fossa and chemotherapy between 1997 and 2006.
  • RESULTS: After IMRT to the posterior fossa, 8 (15%) of 53 patients developed increased fluid-attenuated inversion-recovery signal changes in the brainstem or cerebellum and patchy, multifocal, nodular contrast enhancement at a median of 6 months.
  • In our experience, these transient changes occur at a characteristic time and location after RT, allowing them to be distinguished from leptomeningeal disease.

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  • (PMID = 18485616.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK060445-04; United States / NIDDK NIH HHS / DK / T32 DK060445; United States / NIDDK NIH HHS / DK / T32 DK060445-04; United States / NIDDK NIH HHS / DK / T32 DK06440
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS214776; NLM/ PMC2953789
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3. Regel JP, Schoch B, Sandalcioglu IE, Wieland R, Westermeier C, Stolke D, Wiedemayer H: Malignant meningioma as a second malignancy after therapy for acute lymphatic leukemia without cranial radiation. Childs Nerv Syst; 2006 Feb;22(2):172-5
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  • [Title] Malignant meningioma as a second malignancy after therapy for acute lymphatic leukemia without cranial radiation.
  • RATIONALE: Meningiomas in the pediatric age group are very rare tumors, comprising about 1-4.2% of all primary pediatric intracranial tumors.
  • CASE REPORT: We present a 17-year-old patient who suffered from an intraventricular malignant meningioma.
  • At the age of 2 years, acute lymphatic leukemia (common ALL [cALL]) was diagnosed and successfully treated with chemotherapy.
  • There was no cranial radiation therapy.
  • The tumor was removed completely.
  • Histological diagnosis revealed a malignant papillary meningioma.
  • After removal of a recurrent meningioma 16 months later, he received local radiotherapy.
  • CONCLUSION: Pathogenetic mechanisms, treatment options, and prognosis of meningiomas and secondary malignancies of this age group are discussed.
  • [MeSH-major] Drug-Related Side Effects and Adverse Reactions. Meningeal Neoplasms / etiology. Meningioma / etiology. Neoplasms, Second Primary / etiology
  • [MeSH-minor] Adolescent. Drug Therapy / methods. Humans. Magnetic Resonance Imaging / methods. Male. Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy. Tomography, X-Ray Computed / methods

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  • (PMID = 16456690.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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4. Kawahara I, Masui K, Horie N, Matsuo T, Kitagawa N, Tsutsumi K, Nagata I, Morikawa M, Hayashi T: Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood. Pediatr Neurosurg; 2007;43(1):36-41
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  • [Title] Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood.
  • BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy.
  • Although it was considered to be a poor prognostic disease, modern treatment protocols (aggressive chemotherapy and prophylactic cranial irradiation) have resulted in dramatically improved survival rates.
  • However, ALL patients who undergo this treatment are at risk of developing secondary neoplasms related to treatment, which has become an increasingly recognized problem.
  • CASE DESCRIPTION: A 3-year-old boy with ALL was successfully treated with chemotherapy (vincristine, prednisolone, mercaptopurine and methotrexate) and prophylactic cranial irradiation (total 18 Gy).
  • Computed tomography and magnetic resonance imaging revealed a parasagittal tumor of the left frontoparietal lobe with perifocal edema.
  • The tumor was completely removed surgically and pathohistologically diagnosed as atypical meningioma.
  • CONCLUSION: Long-term survivors who received radiotherapy for ALL in childhood are at risk for late complications, including radiation-induced meningioma.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / etiology. Meningioma / diagnosis. Meningioma / etiology. Neoplasms, Radiation-Induced / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
  • [MeSH-minor] Adult. Child, Preschool. Humans. Male. Radiotherapy / adverse effects. Time Factors


5. Menon R, Muzumdar D, Shah A, Goel A: Glioblastoma multiforme following cranial irradiation and chemotherapy for acute lymphocytic leukaemia. Report of 3 cases. Pediatr Neurosurg; 2007;43(5):369-74
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  • [Title] Glioblastoma multiforme following cranial irradiation and chemotherapy for acute lymphocytic leukaemia. Report of 3 cases.
  • The most common secondary neoplasms which occur following cranial radiation therapy are sarcoma and meningioma.
  • The occurrence of glioblastoma multiforme following radiation and chemotherapy in acute lymphocytic leukaemia (ALL) is rare.
  • We report 3 cases of glioblastoma multiforme in children developing 11-72 months following completion of chemotherapy/radiotherapy for ALL.
  • The exact cause for the development of glioblastoma multiforme following therapy for ALL is not clear.
  • A genetic predisposition may be essential for the occurrence of such a highly malignant primary brain tumour in leukaemia patients, irrespective of radiation and/or chemotherapy.

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17786001.001).
  • [ISSN] 1423-0305
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic
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6. Gupta R, Suri V, Jain A, Sharma MC, Sarkar C, Singh MM, Joshi NP, Puri T, Julka PK: Anaplastic meningioma in an adolescent: a report of a rare case and brief review of literature. Childs Nerv Syst; 2009 Feb;25(2):241-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic meningioma in an adolescent: a report of a rare case and brief review of literature.
  • OBJECTIVE: Anaplastic meningioma is an uncommon neoplasm in childhood and adolescence.
  • Due to the rarity, treatment options for anaplastic meningioma in this age group are not clearly outlined.
  • CASE: A 15-year-old boy presented with a left forehead swelling with a history of a left frontal tumor.
  • Radiological investigations revealed a dura-based tumor with a large extracranial and a smaller intracranial component.
  • Craniotomy with near-total excision of the tumor was performed.
  • Histopathological examination of the tumor showed features of an anaplastic meningioma.
  • The patient is currently receiving radiotherapy and chemotherapy.
  • However, he has developed scalp swellings while on radiotherapy.
  • CONCLUSION: Anaplastic meningioma is extremely rare in children.
  • Extensive sampling is required to recognize the meningothelial nature of the tumor and immunohistochemistry helps in making an accurate diagnosis in such cases.
  • Therapeutic interventions in such cases need to be closely monitored due to the aggressive behavior of this tumor.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / therapy. Meningioma / diagnosis. Meningioma / therapy
  • [MeSH-minor] Adolescent. Combined Modality Therapy. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Mucin-1 / analysis. Vimentin / analysis

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  • (PMID = 18769931.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Mucin-1; 0 / Vimentin
  • [Number-of-references] 11
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7. Ahn JY, Choi EW, Kang SH, Kim YR: Isolated meningeal chloroma (granulocytic sarcoma) in a child with acute lymphoblastic leukemia mimicking a falx meningioma. Childs Nerv Syst; 2002 Apr;18(3-4):153-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated meningeal chloroma (granulocytic sarcoma) in a child with acute lymphoblastic leukemia mimicking a falx meningioma.
  • When dural-based, granulocytic sarcoma may be indistinguishable from meningioma radiologically.
  • CASE HISTORY: We now describe one patient affected by ALL with isolated granulocytic sarcoma mimicking meningioma as initial CNS relapses.
  • A 12-year-old girl who had been diagnosed with ALL and undergone chemotherapy presented with generalized tonic-clonic seizure while in complete remission.
  • Computed tomographic scan and magnetic resonance imaging showed a small mass mimicking a meningioma at the anterior falx.
  • The patient was developed speech disturbance 6 days later.
  • Early detection and antileukemic treatment of granulocytic sarcoma are necessary and important for a favorable prognosis.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Neoplasms, Second Primary / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Sarcoma, Myeloid / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 11981624.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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8. Epstein NE, Drexler S, Schneider J: Clear cell meningioma of the cauda equina in an adult: case report and literature review. J Spinal Disord Tech; 2005 Dec;18(6):539-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell meningioma of the cauda equina in an adult: case report and literature review.
  • In the pediatric population, clear cell meningiomas are more frequently intracranial than intraspinal in location.
  • Tumors recur in up to 40% of cases within 15 postoperative months and are often managed with repeated resection with or without radiation therapy.
  • Preoperative noncontrast MR studies of the brain and cervical and thoracic spine were negative.
  • Frozen-section diagnosis confirmed clear cell tumor.
  • Differential diagnoses included meningioma versus renal cell carcinoma.
  • Negative postoperative chest, abdominal, and pelvic computed tomography studies ruled out tumor of renal cell origin.
  • Consultations with multiple oncologists and radiation therapists recommended neither radiation nor chemotherapy following this initial surgery.
  • The high recurrence rate for clear cell meningiomas in children requires repeated tumor resection with or without secondary radiation therapy.
  • Following gross total resection of lumbar tumors in adults, reserving radiation therapy for secondary recurrences provides optimal management.
  • [MeSH-major] Cauda Equina / pathology. Cauda Equina / surgery. Meningioma / diagnosis. Meningioma / surgery. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Paresis / diagnosis. Paresis / etiology. Treatment Outcome

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  • (PMID = 16306847.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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9. Brassesco MS, Valera ET, Neder L, Castro-Gamero AM, de Oliveira FM, Santos AC, Scrideli CA, Oliveira RS, Machado HR, Tone LG: Childhood radiation-associated atypical meningioma with novel complex rearrangements involving chromosomes 1 and 12. Neuropathology; 2009 Oct;29(5):585-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Childhood radiation-associated atypical meningioma with novel complex rearrangements involving chromosomes 1 and 12.
  • However, cytogenetic studies in childhood atypical radiation-induced meningioma are sporadic, mainly because this condition generally occurs after a long latent period.
  • In the present study we show the results of conventional and molecular cytogenetics in a 14-year-old boy with a secondary atypical meningioma.
  • To the best of our knowledge this is the first report of highly complex chromosome aberrations in the pediatric setting of meningioma.
  • [MeSH-major] Brain Neoplasms / genetics. Chromosome Aberrations. Meningioma / genetics. Neoplasms, Radiation-Induced / genetics. Neoplasms, Second Primary / genetics
  • [MeSH-minor] Adolescent. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 12 / genetics. Chromosomes, Human, Pair 6 / genetics. Combined Modality Therapy. Comparative Genomic Hybridization. Humans. In Situ Hybridization, Fluorescence. Magnetic Resonance Imaging. Male. Medulloblastoma / drug therapy. Medulloblastoma / pathology. Medulloblastoma / radiotherapy

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  • (PMID = 19077038.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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10. Zwerdling T, Dothage J: Meningiomas in children and adolescents. J Pediatr Hematol Oncol; 2002 Mar-Apr;24(3):199-204
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To review the diagnosis, treatment, and long-term outcome of children and adolescents with meningiomas diagnosed by a single institution and compare these findings with other published data.
  • PATIENTS AND METHODS: A 25-year retrospective analysis of 18 patients with meningioma diagnosed at Children's Hospital Medical Center, Cincinnati, Ohio was performed.
  • A literature review of published reports was undertaken to compare evaluation. treatment, and outcome for similar patients.
  • The brain was the primary location of tumor in 17 patients, with the remaining tumor located in the spine.
  • Comorbid diagnoses were common, including developmental delay, balanced chromosomal translocation, type I diabetes mellitus, neurofibromatosis, Klinefelter syndrome, and seizures.
  • Two patients were treated with radiotherapy only, one had chemotherapy only, and two underwent both.
  • CONCLUSIONS: Based on this study and a literature review, the roles of surgery, radiation, and chemotherapy remain unclear.
  • This group of patients has a high incidence of morbidity associated not only with treatment but also with preexisting diseases.
  • These data indicate the need for a national cooperative group study to better understand the evaluation, treatment, and outcome for children and adolescents who are treated for meningiomas.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Child, Preschool. Combined Modality Therapy. Diabetes Insipidus, Neurogenic / etiology. Female. Humans. Infant. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / therapy. Radiotherapy. Retrospective Studies. Seizures / etiology. Treatment Outcome

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  • (PMID = 11990306.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. La Spina M, Dollo C, Giangaspero F, Bertolini P, Russo G: Intracranial mesenchymal chondrosarcoma with osteoid formation: report of a pediatric case. Childs Nerv Syst; 2003 Sep;19(9):680-2
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  • [Title] Intracranial mesenchymal chondrosarcoma with osteoid formation: report of a pediatric case.
  • A presumptive preoperative diagnosis of meningioma was made.
  • DISCUSSION: Clinical features, therapeutic approaches and prognosis of this rare tumour are discussed with regard to the known 30 cases in the literature.
  • [MeSH-minor] Adolescent. Drug Therapy. Female. Headache / etiology. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Radiotherapy. Tomography, X-Ray Computed. Vomiting / etiology

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  • (PMID = 12700920.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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12. Kantar M, Cetingül N, Kansoy S, Anacak Y, Demirtaş E, Erşahin Y, Mutluer S: Radiotherapy-induced secondary cranial neoplasms in children. Childs Nerv Syst; 2004 Jan;20(1):46-9
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  • BACKGROUND: Secondary malignant neoplasms (SMN) in CNS tumor survivors has become problem of increasing concern over the last 20 years.
  • These tumors usually occur in a different site from the primary brain tumor several years after treatment.
  • CASE REPORT: We report secondary cranial malignant neoplasms in three patients who were treated with irradiation and chemotherapy for their primary brain tumors.
  • The first case is a male survivor of an orbital rhabdomyosarcoma who developed a meningioma 8 years later.
  • The other two cases are female survivors of ependymomas who were irradiated at the age of 3 and developed secondary gliomas 8 and 17 years after therapy respectively.
  • CONCLUSION: Patients carry a risk of developing SMNs many years later since irradiation is still an important part of the treatment.
  • An SMN may have a benign course, as in meningioma, or be a dilemma for the patient, as in glioblastoma.
  • [MeSH-major] Meningioma / etiology. Radiotherapy / adverse effects. Rhabdomyosarcoma, Embryonal / etiology

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  • [Cites] Pediatr Radiol. 2001 Sep;31(9):607-9 [11511997.001]
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  • (PMID = 14714135.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / MIB-1 antibody; 0 / S100 Proteins
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13. Beschorner R, Mittelbronn M, Koerbel A, Ernemann U, Thal DR, Scheel-Walter HG, Meyermann R, Tatagiba M: Atypical teratoid-rhabdoid tumor spreading along the trigeminal nerve. Pediatr Neurosurg; 2006;42(4):258-63
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  • [Title] Atypical teratoid-rhabdoid tumor spreading along the trigeminal nerve.
  • We here describe the case of a boy with an atypical teratoid-rhabdoid tumor (ATRT) of the 4th ventricle at 1 year of age and a local tumor recurrence at 19 months of age.
  • Due to brainstem infiltration, only incomplete tumor resection was possible each time.
  • High-dose chemotherapy, stem cell transplantation and irradiation resulted in complete tumor remission on a control MRI.
  • At 8 years of age, another tumor appeared extending from the cerebellopontine angle along the right trigeminal nerve through Meckel's cave into the cavernous sinus.
  • The trigeminal tumor was not in continuity with the primary ATRT but was located within the field of prior irradiation, neuroradiologically mimicking a schwannoma or a meningioma.
  • The origin of the trigeminal tumor as a late metastasis of the former ATRT or as a less likely irradiation-induced secondary ATRT and the operative approach are discussed.
  • [MeSH-major] Brain Neoplasms / diagnosis. Cranial Nerve Neoplasms / diagnosis. Rhabdoid Tumor / diagnosis. Teratoma / diagnosis. Trigeminal Nerve Diseases / diagnosis
  • [MeSH-minor] Chemotherapy, Adjuvant. Child. Fourth Ventricle / pathology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local / therapy. Stem Cell Transplantation

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  • [Copyright] Copyright (c) 2006 S. Karger AG, Basel.
  • (PMID = 16714870.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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14. Stavrou T, Bromley CM, Nicholson HS, Byrne J, Packer RJ, Goldstein AM, Reaman GH: Prognostic factors and secondary malignancies in childhood medulloblastoma. J Pediatr Hematol Oncol; 2001 Oct;23(7):431-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors and secondary malignancies in childhood medulloblastoma.
  • PURPOSE: Little is known of the outcome of long-term survivors of childhood medulloblastoma, one of the most common pediatric malignancies.
  • To determine the potential for secondary malignancies, a retrospective outcome evaluation in 88 consecutive cases of childhood medulloblastoma was performed.
  • PATIENTS AND METHODS: The records of all patients with childhood medulloblastoma diagnosed at Children's National Medical Center in Washington, DC from 1969 through 1997 were reviewed.
  • RESULTS: The median follow-up time was 92 months (range 6-257 months).
  • Univariate analysis showed that age at diagnosis, extent of surgical resection, presence of metastatic disease (M stage), ventriculoperitoneal shunt placement within 30 days from diagnosis, posterior fossa radiation therapy dose, and adjuvant chemotherapy significantly affected survival.
  • Multiple basal cell carcinomas developed in the areas of radiation therapy in two patients; these patients also had nevoid basal cell carcinoma syndrome (NBCCS) diagnosed.
  • One other patient died of glioblastoma multiforme 8 years after treatment of medulloblastoma.
  • A meningioma developed in another patient 10 years after radiation therapy.
  • CONCLUSION: As survival of medulloblastoma patients improves, increased surveillance regarding secondary malignancies is required, especially because radiation-induced tumors may occur many years after treatment.
  • In those patients, alternative therapy should be considered to minimize radiation therapy-related sequelae.
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Child, Preschool. Cohort Studies. Female. Humans. Infant. Male. Neoplasm Recurrence, Local. Prognosis. Radiotherapy. Retrospective Studies. Survival Rate


15. Dagcinar A, Bayrakli F, Yapicier O, Ozek M: Primary meningeal osteosarcoma of the brain during childhood. Case report. J Neurosurg Pediatr; 2008 Apr;1(4):325-9
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  • [Title] Primary meningeal osteosarcoma of the brain during childhood. Case report.
  • Primary meningeal osteosarcomas are rare tumors, with only 19 reported cases in the literature; only 4 of these, including the present case, are in pediatric patients.
  • Initial working diagnoses included meningioma and glioma.
  • After tumor enlargement and progressive symptoms, the patient underwent a large frontotemporal craniotomy and complete resection of the lesion, which recurred 6 and 12 months after the initial surgery and was surgically treated after each recurrence.
  • Because of their fast progression, they must be treated aggressively by means of surgery, chemotherapy, and radiotherapy.
  • [MeSH-major] Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Osteosarcoma / surgery

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  • (PMID = 18377310.001).
  • [ISSN] 1933-0707
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 41
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16. Nakaji P, Meltzer HS, Singel SA, Alksne JF: Improvement of aggressive and antisocial behavior after resection of temporal lobe tumors. Pediatrics; 2003 Nov;112(5):e430
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe 2 cases involving pediatric patients who presented with histories of unusually aggressive and antisocial behavior.
  • After craniotomy for tumor removal, both patients were seizure-free and had marked reductions in their aggressive behavior.
  • It is important to distinguish this subgroup of pediatric patients from those with alternative diagnoses such as attention-deficit/hyperactivity disorder or oppositional defiant disorder.
  • [MeSH-major] Aggression. Brain Neoplasms / psychology. Child Behavior Disorders / etiology. Epilepsy, Complex Partial / etiology. Temporal Lobe
  • [MeSH-minor] Adolescent. Anticonvulsants / therapeutic use. Antipsychotic Agents / therapeutic use. Child, Preschool. Combined Modality Therapy. Craniotomy. Epilepsy, Generalized / drug therapy. Epilepsy, Generalized / etiology. Epilepsy, Generalized / psychology. Epilepsy, Generalized / surgery. Ganglioglioma / psychology. Ganglioglioma / surgery. Humans. Institutionalization. Magnetic Resonance Imaging. Male. Meningeal Neoplasms / psychology. Meningeal Neoplasms / surgery. Meningioma / psychology. Meningioma / surgery. Risperidone / therapeutic use. Suicide, Attempted

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  • (PMID = 14595088.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Antipsychotic Agents; L6UH7ZF8HC / Risperidone
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17. Kobayashi H, Ishii N, Murata J, Saito H, Kubota KC, Nagashima K, Iwasaki Y: Cystic meningioangiomatosis. Pediatr Neurosurg; 2006;42(5):320-4
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  • A 14-year-old boy without any stigmata of neurofibromatosis type 2 presented intractable complex partial and generalized seizures since the age of 12 years.
  • The tumor was located in the leptomeninges and cerebral cortex.
  • The patient underwent surgical treatment because medical treatment with phenytoin and sodium valproate was not sufficient to control the seizures.
  • Histopathology showed specific features of meningioangiomatosis with meningioma-like nodules.
  • [MeSH-major] Angiomatosis / surgery. Brain Diseases / surgery. Cerebral Cortex / surgery. Meninges / surgery
  • [MeSH-minor] Adolescent. Electroencephalography. Humans. Male. Seizures / drug therapy. Seizures / etiology. Seizures / surgery

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16902347.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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18. Benesch M, Siegler N, Hoff Kv, Lassay L, Kropshofer G, Müller H, Sommer C, Rutkowski S, Fleischhack G, Urban C: Safety and toxicity of intrathecal liposomal cytarabine (Depocyte) in children and adolescents with recurrent or refractory brain tumors: a multi-institutional retrospective study. Anticancer Drugs; 2009 Oct;20(9):794-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety and toxicity of intrathecal liposomal cytarabine (Depocyte) in children and adolescents with recurrent or refractory brain tumors: a multi-institutional retrospective study.
  • This retrospective study aimed to evaluate the safety and toxicity of intrathecal liposomal cytarabine (Depocyte) in children and adolescents with refractory or recurrent brain tumors.
  • Nineteen heavily pretreated patients (males, n = 14; females, n = 5; median age at diagnosis 8.5 years; range, 1.4-22 years) were given intrathecal liposomal cytarabine on a compassionate use basis for recurrent refractory medulloblastoma (n = 12), mixed germ cell tumor (n = 2), central nervous system primitive neuroectodermal tumors of the pons (n = 1), anaplastic ependymoma (n = 1), anaplastic oligodendroglioma (n = 1), atypical teratoid rhabdoid tumor (n = 1), or rhabdoid papillary meningioma (n = 1).
  • Duration of treatment ranged from (1/2) to 10 months.
  • Eleven patients (57.9%) did not show any side effects, whereas eight patients (42.1%) developed side effects related to either chemical arachnoiditis (n = 4) or neurological progression (n = 2).
  • Less typical treatment-related symptoms (e.g. lethargy, ataxia, and slurred speech) were observed in two patients.
  • Treatment with intrathecal liposomal cytarabine was discontinued twice because of side effects.
  • In conclusion, although intrathecal liposomal cytarabine was generally well tolerated, it should be used cautiously and only with dexamethasone prophylaxis in extensively pretreated patients with recurrent brain tumors.
  • [MeSH-major] Antimetabolites, Antineoplastic / adverse effects. Brain Neoplasms / drug therapy. Cytarabine / administration & dosage. Cytarabine / adverse effects
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Compassionate Use Trials. Delayed-Action Preparations. Drug Resistance, Neoplasm. Female. Humans. Infant. Injections, Spinal. Liposomes / administration & dosage. Male. Retrospective Studies. Salvage Therapy. Young Adult

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  • (PMID = 19617818.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Delayed-Action Preparations; 0 / Liposomes; 04079A1RDZ / Cytarabine
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