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1. Geener KJ, Feroze M, Geetha K, Jacob AJ: Papillary cystic tumor of pancreas--report of two cases. Indian J Pathol Microbiol; 2002 Jan;45(1):99-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary cystic tumor of pancreas--report of two cases.
  • Two cases of Papillary cystic tumor of pancreas--one metastasizing to lymph node and the other non-metastasizing are reported for their rare occurrence.
  • The histological findings seen in metastasizing tumor were capsular invasion, infiltration to surrounding pancreatic tissue and vascular invasion with metastasis to lymph node.
  • Adjuvant chemotherapy was given for metastasizing tumor and patient is symptom free after 56 month.
  • [MeSH-major] Carcinoma, Papillary / pathology. Pancreas / pathology. Pancreatic Cyst / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Lymphatic Metastasis. Neoplasm Invasiveness

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  • (PMID = 12593574.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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2. Sperti C, Berselli M, Pasquali C, Pastorelli D, Pedrazzoli S: Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults: a case report and review of the literature. World J Gastroenterol; 2008 Feb 14;14(6):960-5
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  • [Title] Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults: a case report and review of the literature.
  • Solid-pseudopapillary tumor (SPT) is a rare neoplasm of the pancreas that usually occurs in young females.
  • It is generally considered a low-grade malignant tumor that can remain asymptomatic for several years.
  • Between 1986 and 2006, 282 cystic tumors of the pancreas were observed.
  • This was diagnosed in a 49-year-old female 13 years after the sonographic evidence of a small pancreatic cystic lesion interpreted as a pseudocyst.
  • The tumor invaded a long segment of the portal-mesenteric vein confluence, and was removed with a total pancreatectomy, resection of the portal vein and reconstruction with the internal jugular vein.
  • Chemotherapy with different drugs was started.
  • Twenty-five patients with invasion of the portal vein and/or of mesenteric vessels were retrieved from the literature, 16 recent patients with tumor relapse after potentially curative resection were also retrieved.
  • The best treatment remains a radical resection whenever possible, even in locally advanced or metastatic disease.
  • The role of chemotherapy, and/or radiotherapy, is still to be defined.
  • [MeSH-major] Cystadenoma, Papillary / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Middle Aged. Recurrence. Treatment Outcome

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  • (PMID = 18240360.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2687069
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3. Huang YD, Hung YC, Yeh LS, Chiang IP, Zeng GC, Chang WC: Synchronous ovarian endometrioid adenocarcinoma and endocervical mucinous adenocarcinoma. Taiwan J Obstet Gynecol; 2006 Sep;45(3):264-7
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  • Computed tomography showed an 18 x 16 cm right pelvic tumor, with both cystic and solid components, ascites and bilateral massive pleural effusion.
  • Extensive tumor thrombi were observed in the lymphovascular channels of the left ovary, bilateral tubes and uterus.
  • Adjuvant chemotherapy with carboplatin and paclitaxel was prescribed postoperatively, but the malignancy was not controlled due to lung, brain and vulva metastases.
  • Diagnosis should be based on histologic examination and requires appropriate treatment for both tumors.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain Neoplasms / secondary. Carcinoembryonic Antigen / metabolism. Combined Modality Therapy. Female. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis. Necrosis. Vulvar Neoplasms / secondary

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  • (PMID = 17175478.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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4. Kanter J, Wilson DB, Strasberg S: Downsizing to resectability of a large solid and cystic papillary tumor of the pancreas by single-agent chemotherapy. J Pediatr Surg; 2009 Oct;44(10):e23-5
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  • [Title] Downsizing to resectability of a large solid and cystic papillary tumor of the pancreas by single-agent chemotherapy.
  • Solid and cystic pseudopapillary tumor (SCPT) is an uncommon cancer that typically affects young women.
  • There are anecdotal reports of the use of neoadjuvant chemotherapy or radiation therapy for patients with unresectable tumors.
  • We report the case of a 14-year-old female with SCPT who was successfully downsized with gemcitabine before definitive surgical resection.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Cystadenoma, Papillary / pathology. Cystadenoma, Papillary / surgery. Deoxycytidine / analogs & derivatives. Neoadjuvant Therapy / methods. Pancreas / drug effects. Pancreas / pathology. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adolescent. Biopsy / methods. Female. Humans. Pancreatectomy. Treatment Outcome

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  • (PMID = 19853735.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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5. Snajdauf J, Rygl M, Petru O, Kalousova J, Kuklova P, Mixa V, Keil R, Hribal Z: Duodenum-sparing technique of head resection in solid pseudopapillary tumor of the pancreas in children. Eur J Pediatr Surg; 2009 Dec;19(6):354-7
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  • [Title] Duodenum-sparing technique of head resection in solid pseudopapillary tumor of the pancreas in children.
  • AIM OF STUDY: Aim of the study was to assess the complications and long-term results in children operated on for solid pseudopapillary tumor of the pancreas (SPTP) between 1993-2008 at the authors' institution with a focus on a novel duodenum-sparing technique to treat tumors of the head of the pancreas.
  • METHODS: Retrospective analysis was performed of patient data including demographics, diagnostic measures, the operative technique focusing on tumor of the head of the pancreas, complications and long-term results.
  • In 7 patients the tumor was localized in the head of the pancreas, in 4 patients in the tail, and in 2 patients both the body and tail were involved.
  • Patients with body and tail involvement underwent distal pancreatic resection.
  • She developed a biliary fistula which closed after three weeks with endoscopic stenting.
  • One patient with head resection developed a biliary fistula which closed after two weeks of stenting.
  • All patients are alive without tumor recurrence at 6 months to 16 years after operation.
  • CONCLUSION: SPTP is a rare pancreatic tumor with a low degree of malignancy.
  • No perioperative chemotherapy is necessary.
  • [MeSH-major] Biliary Fistula / etiology. Carcinoma, Papillary / surgery. Duodenum. Pancreatectomy / adverse effects. Pancreatectomy / methods. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adolescent. Child. Female. Follow-Up Studies. Humans. Male. Retrospective Studies. Treatment Outcome

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart-New York.
  • (PMID = 19821226.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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6. Hah JO, Park WK, Lee NH, Choi JH: Preoperative chemotherapy and intraoperative radiofrequency ablation for unresectable solid pseudopapillary tumor of the pancreas. J Pediatr Hematol Oncol; 2007 Dec;29(12):851-3
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  • [Title] Preoperative chemotherapy and intraoperative radiofrequency ablation for unresectable solid pseudopapillary tumor of the pancreas.
  • Solid pseudopapillary tumor (SPT) is rare primary tumor of the pancreas with low malignant potential affecting adolescent or young women.
  • Radical surgical resection is the definitive treatment for long-term survival even in the patients with metastases.
  • She received preoperative chemotherapy with cisplatinum, ifosfamide, etoposide, and vincristine followed by intraoperative radiofrequency ablation of metastatic liver lesions with surgical resection of the primary tumor successfully.
  • [MeSH-major] Carcinoma, Papillary / surgery. Carcinoma, Papillary / therapy. Catheter Ablation. Pancreatic Neoplasms / surgery. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18090937.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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7. Freda F, Procaccini E, Ruggiero R, Antropoli M, Manganiello A, Nunziata L, Petronella P, Lo Schiavo F: Solid-cystic pseudopapillary tumor of pancreas: description of two cases and literature review. Tumori; 2007 Sep-Oct;93(5):522-5
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  • [Title] Solid-cystic pseudopapillary tumor of pancreas: description of two cases and literature review.
  • The authors report the cases of two young female patients aged 17 and 27 years who underwent surgery for a rare tumor of the pancreas, Frantz's tumor or solid-cystic pseudopapillary tumor.
  • Solid-cystic pseudopapillary tumor of the pancreas is a rare tumor, accounting for 2.7% of pancreatic exocrine tumors.
  • Due to their rareness and behavior, they are often associated with diagnostic and therapeutic problems.
  • In most cases surgical treatment is curative and neither chemotherapy nor radiotherapy should be added.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Pancreatic Neoplasms / diagnosis. Pancreatic Pseudocyst / diagnosis

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  • (PMID = 18038892.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Alexandrescu DT, O'Boyle K, Feliz A, Fueg A, Wiernik PH: Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management. Clin Oncol (R Coll Radiol); 2005 Aug;17(5):358-63
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  • [Title] Metastatic solid-pseudopapillary tumour of the pancreas: clinico-biological correlates and management.
  • Solid-pseudopapillary tumour of the pancreas is a rare neoplasm of young women, currently categorised in the World Health Organization classification under exocrine pancreatic tumours.
  • We describe two patients with solid-pseudopapillary tumour of the pancreas.
  • A smaller, localised tumour in an unusually young white man was surgically excised with no evidence of recurrence after 2 years.
  • A literature review was carried out, and the main clinico-pathological features and strategies of treatment of solid-pseudopapillary tumour of the pancreas are presented.
  • Pathological, genetic and molecular features distinguish solid-pseudopapillary tumours from pancreatic ductal adenocarcinoma.
  • Furthermore, neuroendocrine differentiation can be found focally in occasional cases of solid-pseudopapillary tumour.
  • Chemotherapy and radiation therapy are used in rare cases when resection is not possible.
  • No current chemotherapy regimens are considered standard in the treatment of this tumour.
  • A rational chemotherapy protocol for such a rare tumour needs to consider its origin and clinical behaviour.
  • However, the indolent clinical progression of solid-pseudopapillary tumours is similar to that of pancreatic neuroendocrine tumour.
  • [MeSH-major] Carcinoma, Papillary / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16097567.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Soloni P, Cecchetto G, Dall'igna P, Carli M, Toffolutti T, Bisogno G: Management of unresectable solid papillary cystic tumor of the pancreas. A case report and literature review. J Pediatr Surg; 2010 May;45(5):e1-6
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  • [Title] Management of unresectable solid papillary cystic tumor of the pancreas. A case report and literature review.
  • Pancreatic solid papillary cystic tumor is a rare neoplasm with an excellent prognosis if surgical excision is complete.
  • We report on a case and review 47 more cases extracted from the published literature to assess the treatment options when solid papillary cystic tumor is considered unresectable.
  • Chemotherapy and radiotherapy were beneficial in a limited number of patients, but therapeutic decisions must be made bearing in mind that patients may be long-term survivors without any treatment because of the tumor's slow growth.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Papillary / drug therapy. Neoplasm Recurrence, Local / drug therapy. Neoplasms, Cystic, Mucinous, and Serous / drug therapy. Pancreatic Neoplasms / drug therapy
  • [MeSH-minor] Child. Female. Humans. Tomography, X-Ray Computed

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20438906.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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10. Rebhandl W, Felberbauer FX, Puig S, Paya K, Hochschorner S, Barlan M, Horcher E: Solid-pseudopapillary tumor of the pancreas (Frantz tumor) in children: report of four cases and review of the literature. J Surg Oncol; 2001 Apr;76(4):289-96
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  • [Title] Solid-pseudopapillary tumor of the pancreas (Frantz tumor) in children: report of four cases and review of the literature.
  • BACKGROUND: Solid-pseudopapillary tumor of the pancreas (SPT) is an exceptionally rare neoplasm in children.
  • PATIENTS AND METHODS: A cumulative review of the tumor's clinicopathological characteristics from the world's literature is presented.
  • Surgical procedures included three distal pancreatectomies and one partial duodenopancreatectomy (Whipple procedure).
  • Chemotherapy was initiated for this patient.
  • It is mandatory to establish this diagnosis since complete surgical removal of the tumor even in case of metastases or local invasion offers an excellent prognosis.
  • [MeSH-major] Cystadenoma, Papillary / pathology. Pancreatic Neoplasms / pathology

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  • [Copyright] Copyright 2001 Wiley-Liss, Inc.
  • (PMID = 11320522.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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11. Yang F, Jin C, Long J, Yu XJ, Xu J, Di Y, Li J, Fu de L, Ni QX: Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients. Am J Surg; 2009 Aug;198(2):210-5
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  • [Title] Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients.
  • OBJECTIVE: Solid pseudopapillary tumor (SPT) of the pancreas, which predominantly affects young women, is a relatively indolent entity with favorable prognosis.
  • Clinicopathologic factors were compared between benign and malignant cases to determine what features of the tumor could suggest malignant potential.
  • The neoplasm was localized in the pancreatic head/neck in 14 patients and in the body/tail in 12 patients.
  • All of the tumors-including 8 pancreaticoduodenectomies, 10 distal pancreatectomies, 6 local resections, 1 total pancreatectomy, and 1 central pancreatectomy-were resected successfully.
  • No patient received chemotherapy or radiotherapy after surgery.
  • One of the 2 patients with malignant SPT, in whom Ki-67 immunoreactivity was >25%, developed local recurrence with liver metastasis 4 months and died 6 months after surgery.
  • CONCLUSIONS: SPT is a rare neoplasm with low malignant potential.
  • Characteristic computed axial tomography and magnetic resonance imaging scans combined with age and sex profile should be sufficient for the decision to operate.
  • [MeSH-major] Carcinoma, Papillary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 19268906.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Choi SH, Kim SM, Oh JT, Park JY, Seo JM, Lee SK: Solid pseudopapillary tumor of the pancreas: a multicenter study of 23 pediatric cases. J Pediatr Surg; 2006 Dec;41(12):1992-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid pseudopapillary tumor of the pancreas: a multicenter study of 23 pediatric cases.
  • BACKGROUND/PURPOSE: Solid pseudopapillary tumor (SPT) is a very rare form of childhood pancreatic tumor.
  • This study was intended to analyze the clinicopathologic characteristics of this tumor in childhood.
  • Five (22%) were male, with a male-to-female ratio of 1:3.6.
  • Operative procedures performed were pylorus-preserving pancreaticoduodenectomy (n = 6, 26.1%), distal pancreatectomy (n = 7, 30.4%), distal pancreatectomy with splenectomy (n = 7, 30.4%).
  • One patient showed multiple liver metastasis 3 months after the initial operation and required adjuvant chemotherapy.
  • [MeSH-major] Carcinoma, Papillary / surgery. Pancreatic Neoplasms / surgery

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  • (PMID = 17161189.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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13. Moshel YA, Elliott RE, Monoky DJ, Wisoff JH: Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma. J Neurosurg Pediatr; 2009 Dec;4(6):495-505
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  • Diffusion tensor (DT) imaging and white matter tractography can identify the location of the PLIC in relation to the tumor and may be useful in planning the operative trajectory.
  • This result was compared with the location of the PLIC determined by a blinded radiologist with the use of DT imaging.
  • The utility of DT imaging in determining the surgical approach to a thalamic JPA, degree of resection, and neurological outcomes were all evaluated.
  • Gross-total resection of all cystic and solid tumor components was confirmed on postoperative imaging in all cases.


14. Foltys D, Moench C, Burck I, Hoppe-Lotichius M, Schad A, Teufel A, Heise M, Otto G: [The solid pseudopapillary tumor (SPT)--a rare neoplasm of the pancreas]. Z Gastroenterol; 2008 Jul;46(7):689-94
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  • [Title] [The solid pseudopapillary tumor (SPT)--a rare neoplasm of the pancreas].
  • [Transliterated title] Der solid pseudopapilläre Pankreastumor (SPT)--eine seltene Raumforderung der Bauchspeicheldrüse.
  • BACKGROUND: In general, the rare SPT is a tumour of low malignancy predominantly affecting young women.
  • In exceptional cases the tumour presents as solid pseudopapillary carcinoma (SPC) with typical malignant features and even metastases.
  • Unresectable liver metastases can be treated with RFA, TACE or chemotherapy.
  • For radical tumour removal a pancreato-duodenectomy (n = 3), a distal pancreatectomy (n = 1) and an enucleation (n = 1) were performed.
  • We encountered a mean tumour diameter of 8 cm (range: 6-15 cm), an angioinvasion (3/5) and a lymphatic infiltration (1/5).
  • Chemotherapy has resulted in a survival of over 98 months in a case of SPC with liver metastases.
  • CONCLUSION: SPT is a tumour of low malignancy.
  • Chemotherapy may prolong survival in SPC with unresectable metastases.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Pancreatectomy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Middle Aged. Treatment Outcome

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  • (PMID = 18618380.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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15. Uchida K, Joseph JM, Gapany C, Chardot C: Modified digestive reconstruction with midgut transposition after pylorus-preserving pancreaticoduodenectomy for pancreatic head tumor in childhood. J Pediatr Surg; 2008 Oct;43(10):1932-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modified digestive reconstruction with midgut transposition after pylorus-preserving pancreaticoduodenectomy for pancreatic head tumor in childhood.
  • We describe a new procedure of digestive reconstruction after pylorus-preserving pancreaticoduodenectomy in a 13-year-old girl presenting with a large solid and papillary epithelial neoplasm of the pancreatic head.
  • A midgut transposition (like in a cure of midgut malrotation) was easily performed after tumor removal with minimal additional dissection.
  • [MeSH-major] Cystadenoma, Papillary / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adolescent. Anastomosis, Roux-en-Y. Enzymes / therapeutic use. Exocrine Pancreatic Insufficiency / drug therapy. Exocrine Pancreatic Insufficiency / etiology. Female. Humans. Jejunum / surgery. Pylorus. Remission Induction

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  • (PMID = 18926236.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzymes
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16. Fritzsche FR, Kristiansen G, Frauenfelder T, Opitz I, Bode P, Moch H, Montani M: Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass. Pathol Res Pract; 2009;205(8):572-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass.
  • We present the case of a 26-year-old man with a bland medical history, who presented to the general practitioner because of severe cough and dyspnea.
  • The chest X-ray revealed a massive organ-displacing tumor in the right chest not delineable from the mediastinum.
  • The subsequent needle core biopsy was diagnostic for a mixed germ cell tumor comprising immature teratoma and seminoma.
  • After an initially good response to chemotherapy, tumor markers and tumor size were progressive.
  • The right-sided pneumonectomy revealed an intrapulmonary tumor with cystic and solid components, hemorrhage, and necrosis with a tumor diameter of 18cm.
  • Histology confirmed a teratoma with mature and immature components accompanied by residual seminomatous tumor cells.
  • We describe this exceptional large intrapulmonary germ cell tumor and discuss the spectrum of such rare tumors.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Combined Modality Therapy. Disease Progression. Fatal Outcome. Humans. Male. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 19201104.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Omae T, Takahashi M, Sasajima T, Sugawara T, Kinouchi H, Higashiyama N, Mizoi K: [Supratentorial primitive neuroectodermal tumor: report of a surgical case]. No Shinkei Geka; 2004 Jun;32(6):619-25
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  • [Title] [Supratentorial primitive neuroectodermal tumor: report of a surgical case].
  • A 15-year-old girl presented with a one-month history of headache and vomiting.
  • CT scans showed a huge, solid and cystic tumor with calcification, occupying the left anterior cranial fossa.
  • The solid portion of the tumor was hypointense on T1-weighted images, slightly hyperintense on T2-weighted images, hyperintense on diffusion- weighted images, isointense on fluid-attenuated inversion recovery (FLAIR) images, and strongly enhanced after administration of contrast medium.
  • The expansile tumor had a broad attachment to the dura matter of the anterior cranial fossa.
  • The patient underwent an uneventful extirpation of the tumor.
  • Microscopically, the solid tumor contained small, round poorly-differentiated cells with pleomorphic nuclei and brisk mitotic activity.
  • The tumor cells were immunoreactive for synaptophysin and GFAP, whereas lack of MIC2 gene product expression was confirmed using the monoclonal antibody 12E7.
  • Postoperatively, a dose of 30.6Gy was administrated to the whole brain and a boost of 19.6Gy to the T2-hyperintensity lesion.
  • The patient successively received a dose of 30.4Gy to the whole spine and Linac stereotactic radiotherapy with a marginal dose of 16.8Gy at the tumor bed.
  • Three months after radiotherapy the patient received chemotherapy using carboplatin and etoposide.
  • Follow-up MR images showed no evidence of recurrent tumor 5 months after the radiochemotherapy.
  • On the basis of MR findings on both diffusion-weighted and FLAIR images, preoperative diagnosis of sPNET may be important for choosing appropriate therapeutic strategies for this tumor.

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  • (PMID = 15352632.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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18. Shorter NA, Glick RD, Klimstra DS, Brennan MF, Laquaglia MP: Malignant pancreatic tumors in childhood and adolescence: The Memorial Sloan-Kettering experience, 1967 to present. J Pediatr Surg; 2002 Jun;37(6):887-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Malignant tumors of the pancreas are uncommon in children and adolescents and only recently have the most common tumor types been well characterized.
  • As a result, the treatment approach to these patients has yet to be standardized, and much of the information available in the literature, particularly with regard to the role of chemotherapy and radiation, is anecdotal.
  • The pathologic types were pancreatoblastoma, 5; solid pseudopapillary tumor, 7; acinar cell carcinoma, 1; nonfunctioning pancreatic endocrine neoplasm, 1; malignant VIPoma, 1; and PNET, 2.
  • A complete resection of the primary tumor was achieved in 82%, and 12 of 15 are alive, 10 with no evidence of disease.
  • Chemotherapy or radiation were used in selected cases.
  • The roles of chemotherapy and radiation remain undefined.
  • [MeSH-major] Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Acinar Cell / pathology. Carcinoma, Acinar Cell / therapy. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Neoplasm Recurrence, Local. Pancreatectomy. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Treatment Outcome. Vipoma / pathology. Vipoma / therapy

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  • [Copyright] Copyright 2002, Elsevier Science (USA). All rights reserved.
  • (PMID = 12037756.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Coulson LE, Kong CS, Zaloudek C: Epithelioid trophoblastic tumor of the uterus in a postmenopausal woman: a case report and review of the literature. Am J Surg Pathol; 2000 Nov;24(11):1558-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelioid trophoblastic tumor of the uterus in a postmenopausal woman: a case report and review of the literature.
  • We report an epithelioid trophoblastic tumor (ETT), a recently delineated type of gestational trophoblastic tumor (GTT), discovered in the uterus of a 66-year-old woman.
  • She had been treated for a hydatidiform mole 17 years previously without chemotherapy.
  • The resected uterus contained a solid/cystic tumor located entirely within the myometrium.
  • Microscopically, there was an epithelial-like growth pattern.
  • The tumor was circumscribed, with a pushing border, and the tumor cells grew in cords, nests, and sheets within which were aggregates of hyaline material and necrotic debris.
  • Most tumor cells were mononuclear and had an epithelioid appearance with distinct cell borders, eosinophilic cytoplasm, and nuclei with occasional indistinct nucleoli.
  • The histologic and immunohistochemical features were characteristic of ETT, and helped to distinguish the tumor from other trophoblastic tumors and squamous cell carcinoma.
  • Our findings indicate that ETT, like other types of GTT, can occur in postmenopausal women, even years after a gestational event.
  • [MeSH-major] Epithelioid Cells / pathology. Postmenopause. Trophoblastic Tumor, Placental Site / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Neoplasm Proteins / analysis. Pregnancy. Tomography, X-Ray Computed

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  • (PMID = 11075860.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  • [Number-of-references] 13
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20. Cavallini A, Falconi M, Bortesi L, Crippa S, Barugola G, Butturini G: Pancreatoblastoma in adults: a review of the literature. Pancreatology; 2009;9(1-2):73-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Pancreatoblastoma is a very uncommon neoplasm in adults and its management represents a great challenge with regards to different treatment options.
  • After a search on the Medline database, a review of all cases was performed as well, focusing on clinical, radiological and hystopathological features and treatment options.
  • In general, despite aggressive treatment, pancreatoblastoma in adults is associated with poorer outcome than in children, with a median survival time of 18.5 months.
  • CONCLUSION: Pancreatoblastoma is a rare neoplasm in adults.
  • The differential diagnosis includes nonfunctional pancreatic endocrine tumor, acinar cell carcinoma, solid pseudopapillary tumor and adenocarcinoma.
  • Surgical resection is the only treatment associated with long-term survival.
  • Chemotherapy may play a role as palliative treatment in advanced disease.

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  • [Copyright] Copyright 2008 S. Karger AG, Basel and IAP.
  • (PMID = 19077457.001).
  • [ISSN] 1424-3911
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 36
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21. Gurevich LE, Kazantseva IA: [A solid-pseudopapillary tumors of the pancreas]. Arkh Patol; 2010 Mar-Apr;72(2):52-6
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  • [Title] [A solid-pseudopapillary tumors of the pancreas].
  • The review presents an update of solid-pseudopapillary pancreatic tumors, a rare and inadequately studied type of tumors that are predominantly encountered in girls and young women.
  • It discusses the problems in the diagnosis based on the histological and imunophenotypical uniqueness of these tumors, which allows them to be differentiated from other types of pancreatic tumors with a less favorable prognosis.
  • The correct diagnosis of a solid-pseudopapillary tumor determines the management tactic that requires no radiation or chemotherapy in the vast majority.

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  • (PMID = 20698319.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 50
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22. Maffuz A, Bustamante Fde T, Silva JA, Torres-Vargas S: Preoperative gemcitabine for unresectable, solid pseudopapillary tumour of the pancreas. Lancet Oncol; 2005 Mar;6(3):185-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative gemcitabine for unresectable, solid pseudopapillary tumour of the pancreas.
  • [MeSH-major] Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Pancreatic Neoplasms / drug therapy
  • [MeSH-minor] Adult. Carcinoma, Papillary / drug therapy. Carcinoma, Papillary / surgery. Female. Humans. Neoadjuvant Therapy. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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  • (PMID = 15737835.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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