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1. Ilyas I, Younge DA: Medical management of osteoid osteoma. Can J Surg; 2002 Dec;45(6):435-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Medical management of osteoid osteoma.
  • OBJECTIVE: To see if the results of managing osteoid osteoma with medical treatment alone is comparable to those after surgery or other ablative therapy.
  • PATIENTS: Eleven patients with osteoid osteoma treated over a 5-year period.
  • The condition was diagnosed from a typical history, patient age, standard radiography, computed tomography, bone scanning, complete blood count and measurement of the erythrocyte sedimentation rate.
  • INTERVENTIONS: Continued medical treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) for 6 months after pain ceased.
  • Surgery was done only in those who refused or could not tolerate medical treatment.
  • MAIN RESULTS: Medical treatment successfully controlled the pain in all patients.
  • In 7 patients the symptoms resolved after a mean time of 2.5 years.
  • Two patients were still taking NSAIDS 5 years from the time of diagnosis.
  • CONCLUSIONS: The natural history of osteoid osteoma is self-limited so patients should be offered nonoperative treatment, reserving ablative treatment for those who are unable or unwilling to take NSAIDs until their symptoms resolve.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Bone Neoplasms / drug therapy. Osteoma, Osteoid / drug therapy
  • [MeSH-minor] Adolescent. Adult. Child. Female. Femoral Neoplasms / drug therapy. Humans. Male. Tibia

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  • [CommentIn] Can J Surg. 2003 Feb;46(1):60-1; author reply 61 [12585802.001]
  • (PMID = 12500919.001).
  • [ISSN] 0008-428X
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
  • [Other-IDs] NLM/ PMC3684658
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2. Santiago FR, Del Mar Castellano García M, Montes JL, García MR, Fernández JM: Treatment of bone tumours by radiofrequency thermal ablation. Curr Rev Musculoskelet Med; 2009 Mar;2(1):43-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of bone tumours by radiofrequency thermal ablation.
  • Radiofrequency thermal ablation (RFTA) is considered the treatment of choice for osteoid osteomas, in which it has long been safely used.
  • Other benign conditions (chondroblastoma, osteoblastoma, giant cell tumour, etc.) can also be treated by this technique, which is less invasive than traditional surgical procedures.
  • In some cases, these patients are treated with RFTA because conventional therapies (surgery, radiotherapy, chemotherapy, etc.) have been exhausted.
  • In other cases, it is combined with conventional therapies or other percutaneous treatments, e.g., cementoplasty, offering faster pain relief and bone strengthening.
  • A multidisciplinary approach to the management of these patients is recommended to select the optimal treatment, including orthopaedic surgeons, neurosurgeons, medical and radiation oncologists and interventional radiologists.

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  • (PMID = 19468917.001).
  • [ISSN] 1935-973X
  • [Journal-full-title] Current reviews in musculoskeletal medicine
  • [ISO-abbreviation] Curr Rev Musculoskelet Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2684952
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3. Weingarten TN, Hooten WM, Obray JB: Effective analgesia with tramadol for osteofibrous dysplasia refractory to NSAID medication. J Orthop Res; 2005 Nov;23(6):1495; author reply 1496

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effective analgesia with tramadol for osteofibrous dysplasia refractory to NSAID medication.
  • [MeSH-major] Analgesics, Opioid / therapeutic use. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Fibrous Dysplasia of Bone / drug therapy. Tramadol / therapeutic use
  • [MeSH-minor] Adult. Analgesia. Bone Neoplasms / enzymology. Cyclooxygenase 1 / analysis. Cyclooxygenase 2 / analysis. Female. Humans. Osteoma, Osteoid / enzymology

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  • [CommentOn] J Orthop Res. 2002 Jan;20(1):159-62 [11853083.001]
  • (PMID = 16005174.001).
  • [ISSN] 0736-0266
  • [Journal-full-title] Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • [ISO-abbreviation] J. Orthop. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Anti-Inflammatory Agents, Non-Steroidal; 39J1LGJ30J / Tramadol; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2
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4. von Chamier G, Holl-Wieden A, Stenzel M, Raab P, Darge K, Girschick HJ, Beer M: Pitfalls in diagnostics of hip pain: osteoid osteoma and osteoblastoma. Rheumatol Int; 2010 Jan;30(3):395-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pitfalls in diagnostics of hip pain: osteoid osteoma and osteoblastoma.
  • Osteoid osteoma and osteoblastoma are benign bone tumors that occur most often in adolescents and predominantly in males.
  • Typical clinical symptoms, such as reduced range of motion of adjacent joints, nocturnal bone pain and relief of pain using non-steroidal anti-inflammatory drug therapy especially in osteoid osteoma may lead to the correct diagnosis.
  • In radiographic examinations, the initial changes are often uncharacteristic causing further delay in diagnosis.
  • Magnetic resonance imaging is increasingly used for screening, but early findings in the course of disease might not lead to the definite diagnosis.
  • Both entities (especially osteoid osteoma) occur frequently in the area of the hip.
  • To demonstrate pitfalls in the diagnostic pathway of hip pain caused by benign bone tumors, we present two cases with osteoid osteoma and one with osteoblastoma.
  • [MeSH-major] Arthralgia / etiology. Bone Neoplasms / pathology. Diagnostic Errors / prevention & control. Hip Joint / pathology. Osteoblastoma / pathology. Osteoma, Osteoid / pathology
  • [MeSH-minor] Adolescent. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Arthrography. Child. Diagnosis, Differential. Female. Femur Neck / diagnostic imaging. Femur Neck / pathology. Humans. Magnetic Resonance Imaging / methods. Male. Predictive Value of Tests. Sensitivity and Specificity. Synovial Membrane / diagnostic imaging. Synovial Membrane / pathology. Ultrasonography

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  • (PMID = 19444452.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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5. Jayakumar P, Harish S, Nnadi C, Noordeen H, Saifuddin A: Symptomatic resolution of spinal osteoid osteoma with conservative management: imaging correlation. Skeletal Radiol; 2007 Jun;36 Suppl 1:S72-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Symptomatic resolution of spinal osteoid osteoma with conservative management: imaging correlation.
  • A 10-year-old girl presented with a history of painful scoliosis.
  • Imaging performed, including computed tomography (CT) and magnetic resonance imaging (MRI), demonstrated a lesion with radiological features consistent with an osteoid osteoma (OO) of the 6th thoracic vertebra.
  • The patient was treated conservatively with non-steroidal anti-inflammatory drugs (NSAIDs).
  • The CT and MRI features of the osteoid osteoma during the period of surveillance are presented and are correlated with the corresponding clinical features.
  • [MeSH-major] Osteoma, Osteoid / drug therapy. Spinal Neoplasms / drug therapy
  • [MeSH-minor] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Child. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 16967288.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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6. Kan P, Schmidt MH: Osteoid osteoma and osteoblastoma of the spine. Neurosurg Clin N Am; 2008 Jan;19(1):65-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoid osteoma and osteoblastoma of the spine.
  • Osteoid osteomas and osteoblastomas of the spine are rare primary spine tumors consisting of osteoblasts that produce osteoid and woven bone.
  • The authors review the clinical presentation, radiologic findings, and treatment in osteoid osteoma and osteoblastoma of the spine, with an emphasis on surgical management and outcomes in recent years.
  • [MeSH-major] Osteoblastoma / diagnosis. Osteoblastoma / therapy. Osteoma, Osteoid / diagnosis. Osteoma, Osteoid / therapy. Spinal Neoplasms / diagnosis. Spinal Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Diagnostic Imaging. Female. Humans. Male. Neurosurgical Procedures / methods. Pain / drug therapy. Pain / etiology. Pain / surgery. Scoliosis / etiology. Treatment Outcome

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  • (PMID = 18156049.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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7. Gulati Y, Maheshwari AV: Brodie's abscess of the femoral neck simulating osteoid osteoma. Acta Orthop Belg; 2007 Oct;73(5):648-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brodie's abscess of the femoral neck simulating osteoid osteoma.
  • Subacute osteomyelitis (Brodie's abscess) is essentially a problem of diagnosis, and there may be considerable difficulty in distinguishing it from other benign and malignant bone lesions.
  • The authors present a case of Brodie's abscess in the femoral neck, which clinico-radiologically simulated an osteoid osteoma.
  • Retrospectively, the presence of a cortical sinus tract should have aroused suspicion.
  • [MeSH-major] Bone Neoplasms / diagnosis. Femur Neck / pathology. Osteoma, Osteoid / diagnosis. Osteomyelitis / diagnosis
  • [MeSH-minor] Adolescent. Anti-Infective Agents / therapeutic use. Bone Transplantation. Cloxacillin / therapeutic use. Combined Modality Therapy. Curettage. Diagnosis, Differential. Drug Therapy, Combination. Gentamicins / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18019923.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Gentamicins; O6X5QGC2VB / Cloxacillin
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8. Spouge AR, Thain LM: Osteoid osteoma: MR imaging revisited. Clin Imaging; 2000 Jan-Feb;24(1):19-27
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  • [Title] Osteoid osteoma: MR imaging revisited.
  • To assess and compare with computed tomography (CT) the performance of magnetic resonance (MR) imaging in the detection of osteoid osteoma, and determine the features of this lesion on MR imaging.
  • The prospective MR imaging and CT diagnosis of osteoid osteoma was determined from original radiology reports.
  • MR images were assessed retrospectively with regard to the location and signal intensity of the nidus and surrounding bone marrow and soft tissue edema.
  • These findings were correlated with the age of the patient, duration of symptoms, and drug therapy.
  • Ten patients with histologically proven osteoid osteoma who underwent MR imaging were reviewed.
  • All 10 lesions were correctly diagnosed at the time of MR imaging.
  • Signal intensity of the nidus, marrow, and soft tissue edema on MR imaging were variable.
  • Perinidal edema was most pronounced in younger patients and had no apparent relation to drug therapy.
  • MR imaging reliably demonstrates the nidus of an osteoid osteoma, which has a variable appearance related to its position relative to the cortex of the bone.
  • A predominance of cancellous osteoid osteomas are encountered in patients referred for MR imaging.
  • CT may fail to diagnose osteoid osteoma when the nidus is in a cancellous location, due to the lack of perinidal density alteration.
  • [MeSH-major] Bone Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Osteoma, Osteoid / diagnosis
  • [MeSH-minor] Adolescent. Adult. Bone and Bones / pathology. Bone and Bones / radiography. Child. Contrast Media. Female. Gadolinium DTPA. Humans. Male. Middle Aged. Prospective Studies. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 11120413.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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9. Mintz S, Velez I: Osteoid osteoma of the zygoma: report of an unusual case. J Am Dent Assoc; 2007 Jun;138(6):793-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoid osteoma of the zygoma: report of an unusual case.
  • BACKGROUND: Osteoid osteoma is a benign tumor of bone characterized by pain, usually occurring at night, that shows a dramatic response to aspirin.
  • CASE DESCRIPTION: The authors present an unusual case of an osteoid osteoma of the craniofacial bones.
  • On the basis of the images and the biopsy report, the authors made a diagnosis of osteoid osteoma.
  • In this article, they describe the treatment of and new modalities of therapy for this condition.
  • [MeSH-major] Osteoma, Osteoid / pathology. Zygoma / pathology
  • [MeSH-minor] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Aspirin / therapeutic use. Facial Pain / drug therapy. Facial Pain / etiology. Humans. Male. Middle Aged

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  • (PMID = 17545268.001).
  • [ISSN] 0002-8177
  • [Journal-full-title] Journal of the American Dental Association (1939)
  • [ISO-abbreviation] J Am Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; R16CO5Y76E / Aspirin
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10. Carpintero-Benitez P, Aguirre MA, Serrano JA, Lluch M: Effect of rofecoxib on pain caused by osteoid osteoma. Orthopedics; 2004 Nov;27(11):1188-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of rofecoxib on pain caused by osteoid osteoma.
  • In a prospective study, nine patients with osteoid osteoma were treated with a selective cyclooxygenase-2 inhibitor (rofecoxib).
  • Patient pain perception with no treatment, with conventional nonsteroidal anti-inflammatory drug (NSAID) treatment, and with rofecoxib therapy was compared using a visual analog scale.
  • Tumor response was also monitored by radiographs, computed tomography, and bone scintigraphy.
  • Four patients underwent surgery whereas in the remaining five patients, bone scintigraphy showed reduced uptake after 6 months.
  • These four patients are currently asymptomatic and are not receiving any treatment, whereas the fifth patient is still receiving therapy.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Lactones / administration & dosage. Pain, Intractable / drug therapy. Sulfones / administration & dosage
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / complications. Bone Neoplasms / radionuclide imaging. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Follow-Up Studies. Humans. Male. Osteoma, Osteoid / complications. Osteoma, Osteoid / radionuclide imaging. Pain Measurement. Prospective Studies. Risk Assessment. Severity of Illness Index. Treatment Outcome

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  • (PMID = 15566132.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Lactones; 0 / Sulfones; 0QTW8Z7MCR / rofecoxib
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11. Bottner F, Roedl R, Wortler K, Grethen C, Winkelmann W, Lindner N: Cyclooxygenase-2 inhibitor for pain management in osteoid osteoma. Clin Orthop Relat Res; 2001 Dec;(393):258-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclooxygenase-2 inhibitor for pain management in osteoid osteoma.
  • Thirteen patients with osteoid osteoma were enrolled in a prospective trial to test whether rofecoxib, a selective cyclooxygenase-2 inhibitor, is as effective for pain control as acetylsalicylic acid.
  • Each patient documented the pain level using a visual analog scale, with 0 being no pain and 10 being unbearable pain, during 2 days of no pain medication, 4 days of 500 mg acetylsalicylic acid three times a day, and 10 days of 25 mg rofecoxib once a day.
  • Oral administration of 500 mg acetylsalicylic acid three times a day led to a significant decrease in pain at night, pain at rest, and pain induced by exercise.
  • Results of the current study suggest that pain induction in osteoid osteoma is related to cyclooxygenase-2, an enzyme that is blocked by acetylsalicylic acid and rofecoxib.
  • Conservative medical treatment with rofecoxib for osteoid osteoma is recommended when percutaneous intervention is associated with significant morbidity.
  • [MeSH-major] Bone Neoplasms / complications. Cyclooxygenase Inhibitors / therapeutic use. Isoenzymes / antagonists & inhibitors. Lactones / therapeutic use. Osteoma, Osteoid / complications. Pain / drug therapy
  • [MeSH-minor] Adolescent. Adult. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Aspirin / therapeutic use. Cyclooxygenase 2. Cyclooxygenase 2 Inhibitors. Female. Humans. Male. Membrane Proteins. Pain Measurement. Prospective Studies. Prostaglandin-Endoperoxide Synthases. Sulfones

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  • (PMID = 11764357.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors; 0 / Cyclooxygenase Inhibitors; 0 / Isoenzymes; 0 / Lactones; 0 / Membrane Proteins; 0 / Sulfones; 0QTW8Z7MCR / rofecoxib; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; R16CO5Y76E / Aspirin
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12. Meijer-Jorna LB, Slingerland AC, Blaauwgeers JL: [Diagnostic image (93). A boy with a painful leg swelling. Osteoid osteoma]. Ned Tijdschr Geneeskd; 2002 Jun 22;146(25):1179
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  • [Title] [Diagnostic image (93). A boy with a painful leg swelling. Osteoid osteoma].
  • [Transliterated title] Diagnose in beeld (93). Een jongen met een pijnlijke crurale zwelling. Osteoïd osteoom.
  • A 13-year-old boy presented with a swelling on his left lower leg and suffered from pain, which was almost immediately relieved by acetylsalicylic acid.
  • Roentgenographic and histologic appearance demonstrated an osteoid osteoma in the tibia.
  • [MeSH-major] Bone Neoplasms / diagnosis. Osteoma, Osteoid / diagnosis. Tibia
  • [MeSH-minor] Adolescent. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Aspirin / therapeutic use. Humans. Male. Pain / drug therapy. Pain / etiology

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  • (PMID = 12109308.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; R16CO5Y76E / Aspirin
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13. Akgül S, Uzümcügil A, Bozkurt MF, Topçu M: Osteoid osteoma in a 16-year-old boy presenting with atrophy of the left thigh: diagnostic difficulties. Turk J Pediatr; 2008 Jul-Aug;50(4):373-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoid osteoma in a 16-year-old boy presenting with atrophy of the left thigh: diagnostic difficulties.
  • Osteoid osteoma is an osteoblastic benign lesion of the bone.
  • The pathognomonic symptom is significant pain, which responds well to nonsteroidal antiinflammatory drugs.
  • When typical clinical and radiological features are present, the diagnosis is not difficult.
  • However, if the lesion is in an area not clearly seen on plain radiographs, or clinical features are atypical, then diagnosis becomes difficult.
  • We present a case of osteoid osteoma with delayed diagnosis that presented itself with neurological signs.
  • Prominent features present in the patient included pain that responded well to medication and muscle atrophy, which led to a wider differential diagnosis.
  • Diagnosis was made approximately two years after the onset of his initial symptoms, after having been investigated and treated both in our own hospital and elsewhere.
  • This case illustrates clinical and radiological diagnostic problems of osteoid osteoma, demonstrating that it can present itself with neurological signs.
  • Correct diagnosis then requires detailed history and clinical awareness.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Femur / pathology. Osteoma, Osteoid / diagnosis. Pain / drug therapy. Pain / etiology

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  • (PMID = 19014052.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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14. Gross M, Dano I, Hocwald E, Eliashar R: Osteoid osteoma of the frontal bone. Ann Otol Rhinol Laryngol; 2003 Jun;112(6):567-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoid osteoma of the frontal bone.
  • [MeSH-major] Bone Neoplasms / diagnostic imaging. Frontal Bone. Osteoma, Osteoid / diagnostic imaging
  • [MeSH-minor] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Child. Chronic Disease. Diagnosis, Differential. Forehead. Headache / drug therapy. Headache / etiology. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 12834128.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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15. Clayer M: Osteoid osteoma in a young child: successful non-operative management. ANZ J Surg; 2002 Feb;72(2):168
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  • [Title] Osteoid osteoma in a young child: successful non-operative management.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Naproxen / therapeutic use. Osteoma, Osteoid / drug therapy
  • [MeSH-minor] Age Factors. Child. Humans. Time Factors

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  • [CommentOn] ANZ J Surg. 2001 Aug;71(8):491-3 [11504296.001]
  • (PMID = 12074075.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 57Y76R9ATQ / Naproxen
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16. Leicester AW, Trantalis JN: Osteoid osteoma in a young child: successful non-operative management. ANZ J Surg; 2001 Aug;71(8):491-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoid osteoma in a young child: successful non-operative management.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Bone Neoplasms / drug therapy. Bone Neoplasms / radiography. Naproxen / therapeutic use. Osteoma, Osteoid / drug therapy. Osteoma, Osteoid / radiography. Tibia / radiography
  • [MeSH-minor] Female. Humans. Infant. Osteosclerosis / drug therapy. Osteosclerosis / radiography

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  • [CommentIn] ANZ J Surg. 2002 Feb;72(2):168 [12074075.001]
  • (PMID = 11504296.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 57Y76R9ATQ / Naproxen
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17. Knoeller SM, Uhl M, Adler CP, Herget GW: Differential diagnosis of benign tumors and tumor-like lesions in the spine. Own cases and review of the literature. Neoplasma; 2004;51(2):117-26
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  • [Title] Differential diagnosis of benign tumors and tumor-like lesions in the spine. Own cases and review of the literature.
  • Although benign tumors and tumor-like lesions of the spine are shown in every orthopedic teaching book, it is often surprising how little attention is paid to the differential diagnosis and diagnostic investigations, respectively, since surgical treatment and postoperative control depends on exact diagnosis.
  • Bone deviations are diagnosed radiologically.
  • Different types of benign bone tumors and tumor-like lesions of the spine including osteochondroma, osteoblastoma, osteoid osteoma, aneurysmal bone cyst, eosinophilic granuloma, hemangioma, and giant cell tumor, their appearance relation to the age and location in the spine were reviewed and the common histologic subtypes described.
  • Treatment including radiation, chemotherapy and the surgical procedure as well as the postoperative treatment of patients with benign tumors and tumor-like lesions of the spine are discussed.
  • [MeSH-major] Bone Neoplasms / diagnosis. Bone Neoplasms / pathology. Spine / pathology
  • [MeSH-minor] Adult. Back Pain. Biopsy, Needle. Child. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 15190421.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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18. Ruggieri P, Angelini A, Montalti M, Pala E, Calabrò T, Ussia G, Abati CN, Mercuri M: Tumours and tumour-like lesions of the hip in the paediatric age: a review of the Rizzoli experience. Hip Int; 2009 Jan-Mar;19 Suppl 6:S35-45
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  • Bone tumours and tumour-like lesions of the hip in children are rare.
  • Delay of diagnosis is not uncommon.
  • A high index of suspicion in young patients presenting with persistent pain and without history of trauma, that is unresolved with conservative therapy should prompt further investigation, including radiographs or computed tomography scan of the pelvis.
  • Tumour-like lesions accounted for 322 cases (simple bone cyst in 255, eosinophilic granuloma in 43, aneurismal bone cyst in 34), benign tumours for 340 cases (osteoid osteoma in 229, fibrous dysplasia in 63, exostosis in 48) and malignant tumours for 80 cases (Ewing's sarcoma in 53 and osteosarcoma in 27).
  • The epidemiology, pathology, clinical presentation, and radiograph findings are discussed for each of these tumours.Treatment of these tumours differs from observation or minimally invasive treatment for most pseudotumoural lesions, intralesional excision or termoablation for benign bone tumours and wide resection for malignant bone tumours.
  • In this latter group, chemotherapy is required and often administered pre- and postoperatively.
  • [MeSH-major] Femoral Neoplasms / pathology. Hip. Osteoma, Osteoid / pathology. Sarcoma, Ewing / pathology
  • [MeSH-minor] Adolescent. Bone Cysts, Aneurysmal / epidemiology. Bone Cysts, Aneurysmal / pathology. Bone Cysts, Aneurysmal / therapy. Child. Child, Preschool. Databases, Factual. Eosinophilic Granuloma / epidemiology. Eosinophilic Granuloma / pathology. Eosinophilic Granuloma / therapy. Exostoses / epidemiology. Exostoses / pathology. Exostoses / therapy. Female. Fibrous Dysplasia, Monostotic / epidemiology. Fibrous Dysplasia, Monostotic / pathology. Fibrous Dysplasia, Monostotic / therapy. Humans. Infant. Italy / epidemiology. Male. Pain

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  • (PMID = 19306246.001).
  • [ISSN] 1724-6067
  • [Journal-full-title] Hip international : the journal of clinical and experimental research on hip pathology and therapy
  • [ISO-abbreviation] Hip Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Jakobs TF, Hoffmann RT, Vick C, Wallnöfer A, Reiser MF, Helmberger TK: [RFA of bone and soft tissue tumors]. Radiologe; 2004 Apr;44(4):370-5
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  • [Title] [RFA of bone and soft tissue tumors].
  • [Transliterated title] RFA von Tumoren des Knochens und der Weichteile.
  • A new field of RFA is the minimal invasive therapy of osseous and soft tissue tumors.
  • In the management of osteoid-osteoma, RFA is a well established treatment option.
  • A careful evaluation of indications for RFA in osseous or soft tissue neoplasms is mandatory.
  • In patients who are neither candidates for surgical tumor resection nor respond to chemotherapy, there is a need for alternative treatment options.
  • In malignancies of bone and soft-tissue tumors, RFA is a palliative treatment option.
  • Therefore, the results can not be compared to those of surgical resection or chemotherapy which essentially are employed with curative intention.
  • The high technical and clinical success together with a low complication rate makes RFA of osseous and soft tissue neoplasms a valuable supportive tool for patients not referable for surgery or systemic therapy.
  • [MeSH-major] Bone Neoplasms / therapy. Catheter Ablation / methods. Osteoma, Osteoid / therapy. Palliative Care / methods
  • [MeSH-minor] Humans. Patient Selection. Treatment Outcome

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  • [Cites] Radiology. 2004 Jan;230(1):135-41 [14631050.001]
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  • (PMID = 15048556.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 33
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20. Winkelmann S, Hirsch W, Burdach S, Horneff G: [Therapy of osteoid osteomas -- always surgically?]. Klin Padiatr; 2003 Jan-Feb;215(1):35-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Therapy of osteoid osteomas -- always surgically?].
  • [Transliterated title] Therapie der Osteoidosteome -- immer chirurgisch?
  • Osteoidosteomas are common bone tumours in childhood.
  • The tumour is benign and noninfiltrative.
  • Typical complaints are nightly pain attacks, which are relieved by nonsteroidal antiinflammatory drugs.
  • On X-ray, the classic finding is a small radiolucent area surrounded by sclerotic bone in the cortex.
  • Surgical excision is often recommended, providing the possibility for a histological diagnosis.
  • Therapeutic alternatives are percutaneous coagulation of the nidus by alcohol or laser, thermo-coagulation or high-frequency radioablation.
  • Therefore the decision to wait and see and to treat with antiinflammatory medication is a considerable therapeutic option.
  • One of them underwent an unsuccessful trial for surgical extirpation and histological examination but afterwards developed a severe hip contraction with scoliosis.
  • Pain was completely controlled upon treatment with nonsteroidal antiinflammatory drugs in both patients.
  • In conclusion, pharmacomedical therapy can be recommended, if the diagnosis is doubtlessly and a close follow up is established.
  • The risk of anaesthesia and surgical treatment should be weighted against the risk of nonsteroidal antiinflammatory drug treatment.
  • [MeSH-major] Femoral Neoplasms / therapy. Osteoma, Osteoid / therapy
  • [MeSH-minor] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Child. Diclofenac / therapeutic use. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Physical Therapy Modalities. Time Factors. Tomography, Emission-Computed. Tomography, X-Ray Computed

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  • (PMID = 12545424.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 144O8QL0L1 / Diclofenac
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21. La Spina M, Dollo C, Giangaspero F, Bertolini P, Russo G: Intracranial mesenchymal chondrosarcoma with osteoid formation: report of a pediatric case. Childs Nerv Syst; 2003 Sep;19(9):680-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial mesenchymal chondrosarcoma with osteoid formation: report of a pediatric case.
  • CASE REPORT: We present a case of a 14-year-old girl with a 3-week history of severe progressive headache and intermittent vomiting.
  • A presumptive preoperative diagnosis of meningioma was made.
  • Histologically the neoplasms had the classic features of a mesenchymal chondrosarcoma associated with the focal presence of osteoid matrix.
  • DISCUSSION: Clinical features, therapeutic approaches and prognosis of this rare tumour are discussed with regard to the known 30 cases in the literature.
  • [MeSH-major] Bone Neoplasms / complications. Chondrosarcoma, Mesenchymal / complications. Osteoma, Osteoid / etiology
  • [MeSH-minor] Adolescent. Drug Therapy. Female. Headache / etiology. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Radiotherapy. Tomography, X-Ray Computed. Vomiting / etiology

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  • (PMID = 12700920.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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22. Hsu CS, Hentz VR, Yao J: Tumours of the hand. Lancet Oncol; 2007 Feb;8(2):157-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hand tumours of soft-tissue and bony origin are frequently encountered, and clinicians must be able to distinguish typical benign entities from life-threatening or limb-threatening malignant diseases.
  • In this Review, we present a diagnostic approach to hand tumours and describe selected cancers and their treatments.
  • Soft-tissue tumours include ganglion cysts, giant-cell cancers and fibromas of the tendon sheath, epidermal inclusion cysts, lipomas, vascular lesions, peripheral-nerve tumours, skin cancers, and soft-tissue sarcomas.
  • Bony tumours encompass enchondromas, aneurysmal bone cysts, osteoid osteomas, giant-cell lesions of bone, bone sarcomas, and metastases.
  • We look at rates of recurrence and 5-year survival, and recommendations for adjunct chemotherapy and radiotherapy for malignant lesions.
  • [MeSH-major] Bone Neoplasms / pathology. Hand. Soft Tissue Neoplasms / pathology

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  • (PMID = 17267330.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 76
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23. Poggi G, Gatti C, Melazzini M, Bernardo G, Strada M, Teragni C, Delmonte A, Tagliaferri C, Bonezzi C, Barbieri M, Bernardo A, Fratino P: Percutaneous ultrasound-guided radiofrequency thermal ablation of malignant osteolyses. Anticancer Res; 2003 Nov-Dec;23(6D):4977-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Radiotherapy, surgery and chemotherapy are the cornerstones of the treatment, but these techniques are not completely effective.
  • Radiofrequency thermal ablation (RFA) may offer an alternative to conventional therapies for pain control.
  • At present, the main field of application of RFA is the treatment of primary or secondary tumors of the liver but, recently, the technique has been effectively used to treat various other tumors in organs such as the prostate, kidney, lung, brain, pancreas and breast and to control pain caused by osteoid osteomas.
  • Five patients with six painful bone metastases underwent RFA.
  • One patient was completely pain free within 48 hours of the procedure and the control of pain persisted for 88 weeks.
  • Our preliminary results confirm that ultrasound-guided RFA is a simple and safe technique for treating painful superficial bone metastases.
  • [MeSH-major] Bone Neoplasms / secondary. Bone Neoplasms / surgery. Catheter Ablation / methods. Osteolysis / surgery

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  • (PMID = 14981955.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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