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1. Atanasov DT, Indjov SI, Lalabonova HK, Neichev DS: Sarcomas of the mandible. Literature review and case reports. Folia Med (Plovdiv); 2004;46(2):31-5
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  • Sarcomas of the maxillofacial region are rare tumors presenting with wide variety of histopathological and clinical features.
  • The present study reports three cases (osteogenic sarcoma, fibrosarcoma, chondrosarcoma) with specific clinical and radiographic characteristics, demonstrating the differences between the various types of sarcomas.
  • Special attention is paid to the first clinical signs and symptoms, and to the differential diagnosis with inflammatory conditions (post-extraction alveolitis, chronic odontogenic osteomyelitis), benign tumors (osteoblastoclastoma, ameloblastoma, odontogenic cysts, fibrous dysplasia) and centrally developing jaw carcinomas.
  • Particular emphasis is given to CT imaging and morphological examinations in making an accurate diagnosis and providing adequate treatment.
  • Early diagnosis and precise surgical treatment (total resection or hemiexarticulation, or neck dissection if submandibular or cervical metastases are present) are essential to achieve satisfactory management of these malignant neoplasms.
  • The radiotherapy and chemotherapy administered according to the histologic features of the tumor are also of significance.
  • [MeSH-major] Chondrosarcoma / diagnosis. Fibrosarcoma / diagnosis. Mandibular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 15506548.001).
  • [ISSN] 0204-8043
  • [Journal-full-title] Folia medica
  • [ISO-abbreviation] Folia Med (Plovdiv)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Bulgaria
  • [Number-of-references] 21
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2. Gosau M, Draenert FG, Müller S, Frerich B, Bürgers R, Reichert TE, Driemel O: Two modifications in the treatment of keratocystic odontogenic tumors (KCOT) and the use of Carnoy's solution (CS)--a retrospective study lasting between 2 and 10 years. Clin Oral Investig; 2010 Feb;14(1):27-34
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  • [Title] Two modifications in the treatment of keratocystic odontogenic tumors (KCOT) and the use of Carnoy's solution (CS)--a retrospective study lasting between 2 and 10 years.
  • This retrospective study aimed at evaluating the recurrence rates of keratocystic odontogenic tumors (KCOTs) that were enucleated with and without the application of Carnoy's solution (CS).
  • Recurrence rates were investigated in correlation with the respective treatment method applied.
  • Additionally, any damage to the inferior alveolar nerve associated with treatment was analyzed.
  • Treatments consisted of enucleation with (38.9%) or without (61.1%) the application of CS.
  • [MeSH-major] Acetic Acid / therapeutic use. Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant / methods. Chloroform / therapeutic use. Ethanol / therapeutic use. Jaw Neoplasms / drug therapy. Neoplasm Recurrence, Local / prevention & control. Odontogenic Tumors / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Cautery / methods. Child. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Mandibular Nerve / drug effects. Middle Aged. Neovascularization, Pathologic / drug therapy. Retrospective Studies. Young Adult

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  • [CommentIn] Clin Oral Investig. 2010 Dec;14(6):719-21 [20838833.001]
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  • (PMID = 19294436.001).
  • [ISSN] 1436-3771
  • [Journal-full-title] Clinical oral investigations
  • [ISO-abbreviation] Clin Oral Investig
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Carnoy's solution; 3K9958V90M / Ethanol; 7V31YC746X / Chloroform; Q40Q9N063P / Acetic Acid
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3. Huguet P, Castellví J, Avila M, Alejo M, Autonell F, Basas C, Bescos MS: Ameloblastic fibrosarcoma: report of a case. Immunohistochemical study and review of the literature. Med Oral; 2001 May-Jul;6(3):173-9
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  • Ameloblastic fibrosarcoma is a rare malignant odontogenic tumour characterized by a benign epithelial component within a malignant fibrous stroma.
  • Its behaviour is relatively benign, with absence of metastatic disease, and the prognosis is reported to be good.
  • It is a paradoxical neoplasm with "sarcomatous" morphological and immunohistochemical patterns but with a favourable clinical course.
  • We report a new case of this tumour in a mandibular ramus of a 31-years-old male patient, that was surgically excised and treated with adjuvant chemotherapy and radiotherapy.
  • Five years later the patient is free of disease.
  • The growth potential of ameloblastic fibrosarcoma is evaluated and compared with a related lesion, the ameloblastic fibroma.
  • [MeSH-major] Mandibular Neoplasms / pathology. Odontogenic Tumors / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Epithelial Cells / pathology. Follow-Up Studies. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Mesoderm / pathology. Prognosis. Proliferating Cell Nuclear Antigen / analysis. Radiotherapy, Adjuvant. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 11500634.001).
  • [ISSN] 1137-2834
  • [Journal-full-title] Medicina oral : órgano oficial de la Sociedad Española de Medicina Oral y de la Academia Iberoamericana de Patología y Medicina Bucal
  • [ISO-abbreviation] Med Oral
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53
  • [Number-of-references] 16
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4. Avon SL, McComb J, Clokie C: Ameloblastic carcinoma: case report and literature review. J Can Dent Assoc; 2003 Oct;69(9):573-6
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  • It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption and tooth mobility.
  • Because the lesion is usually found unexpectedly after an incisional biopsy or the removal of a cyst, a guide to differential diagnosis is not usually useful.
  • The tumour cells resemble the cells seen in ameloblastoma, but they show cytologic atypia.
  • Direct extension of the tumour, lymph node involvement and metastasis to various sites (frequently the lung) have been reported.
  • Wide local excision is the treatment of choice.
  • Radiotherapy and chemotherapy seem to be of limited value for the treatment of ameloblastic carcinomas.
  • At the moment, there are too few reported cases to make a definite recommendation regarding treatment.
  • [MeSH-major] Ameloblastoma / pathology. Maxillary Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 14653932.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 22
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5. Ricard AS, Majoufre-Lefebvre C, Siberchicot F, Laurentjoye M: A multirecurrent ameloblastoma metastatic to the lung. Rev Stomatol Chir Maxillofac; 2010 Apr;111(2):98-100
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  • INTRODUCTION: The ameloblastoma is a rare tumor of odontogenic epithelial origin.
  • It is a neoplasm in which ameloblastic features are revealed by the primary growth in jaws and by any metastatic growth.
  • The curative treatment is surgical.
  • The results of palliative chemotherapy and radiotherapy are not always efficient.
  • [MeSH-major] Ameloblastoma / pathology. Ameloblastoma / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology. Mandibular Neoplasms / surgery
  • [MeSH-minor] Adult. Bone Transplantation. Humans. Lung / surgery. Male. Mandible / surgery. Neoplasm Recurrence, Local / surgery. Reconstructive Surgical Procedures

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  • (PMID = 20347463.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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6. Nakano H, Ota Y, Yura Y: Calcifying epithelial odontogenic tumor of the maxilla with ulcerative stomatitis: a case report. Br J Oral Maxillofac Surg; 2009 Apr;47(3):222-4
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  • [Title] Calcifying epithelial odontogenic tumor of the maxilla with ulcerative stomatitis: a case report.
  • Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic tumor, known as Pindborg tumor.
  • [MeSH-major] Gingivitis, Necrotizing Ulcerative / etiology. Maxillary Neoplasms / pathology. Odontogenic Tumors / pathology
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Calcinosis. Female. Humans. Mouth Mucosa / pathology. Mucositis / drug therapy. Mucositis / etiology. Mucositis / pathology

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  • (PMID = 18790551.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal
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7. Mosqueda Taylor A, Meneses García A, Ruíz Godoy Rivera LM, Suárez Roa Mde L, Luna Ortiz K: Malignant odontogenic tumors. A retrospective and collaborative study of seven cases. Med Oral; 2003 Mar-Apr;8(2):110-21
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  • [Title] Malignant odontogenic tumors. A retrospective and collaborative study of seven cases.
  • The frequency, clinico-pathologic features and outcome of malignant odontogenic tumors diagnosed according to the current WHO classification in three pathology services in Mexico City are presented.
  • There were seven cases (5 male and 2 female patients), which represent less than 4% of all odontogenic tumors diagnosed in these services.
  • There were six odontogenic carcinomas (two malignant ameloblastomas, two clear cell odontogenic carcinomas, one primary intraosseous carcinoma and one carcinoma arising in an odontogenic cyst) and one ameloblastic fibrosarcoma.
  • Clear cell odontogenic carcinomas occurred in the canine-premolar region, one in the maxilla and one in the mandible (one ia a man and one in a woman), while the remaining lesions affected the posterior region of the mandible, with a male predominance (4:1), which agrees with previously reported cases.
  • Surgical resection was the treatment employed in all carcinomas, while the ameloblastic fibrosarcoma was treated with chemotherapy due to its large extension, but without favorable response.
  • The patient with primary intraosseous carcinoma had submaxillary and cervical metastases and the neoplasm was the cause of death.
  • In spite of their extremely low frequency, malignant odontogenic tumors are an important cause of extensive surgical procedures in the oral and maxillofacial region.
  • [MeSH-major] Odontogenic Tumors / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Adult. Aged. Ameloblastoma / pathology. Female. Humans. Male. Mandibular Neoplasms / pathology. Middle Aged. Odontogenic Cysts / pathology. Prospective Studies. Retrospective Studies

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  • (PMID = 12618671.001).
  • [ISSN] 1137-2834
  • [Journal-full-title] Medicina oral : órgano oficial de la Sociedad Española de Medicina Oral y de la Academia Iberoamericana de Patología y Medicina Bucal
  • [ISO-abbreviation] Med Oral
  • [Language] eng; spa
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Spain
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8. Ram H, Mohammad S, Husain N, Gupta PN: Ameloblastic carcinoma. J Maxillofac Oral Surg; 2010 Dec;9(4):415-9
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  • Ameloblastic carcinoma (AC) is a rare aggressive malignant epithelial odontogenic tumor of the maxillofacial skeleton with a distinct predilection in the mandible.
  • It may appear de novo or originate from a pre-existing ameloblastoma or odontogenic cyst.
  • It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption and tooth mobility.
  • Direct extension of the tumour, lymph node involvement and metastasis to various sites has been reported.
  • Wide local excision is the treatment of choice.
  • Radiotherapy and chemotherapy have limited role in the treatment of ameloblastic carcinomas.

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  • (PMID = 22190836.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177477
  • [Keywords] NOTNLM ; Ameloblastic carcinoma / Ameloblastoma / Odontogenic tumor
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9. Yamada T, Ueno T, Moritani N, Mishima K, Hirata A, Matsumura T: Primary intraosseous squamous cell carcinomas: five new clinicopathologic case studies. J Craniomaxillofac Surg; 2009 Dec;37(8):448-53
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  • Primary intraosseous squamous cell carcinomas (PIOSCCs) are rare malignant tumours which arise from odontogenic epithelial remnants.
  • Herein we report five new PIOSCC cases, affecting three female and two male patients with a mean age of 64.4 years.
  • Histopathologically, four cases were diagnosed as well-differentiated PIOSCCs arising de novo or from odontogenic cysts.
  • In four cases, treatment consisted of surgical removal with perioperative radiotherapy or chemotherapy.
  • The lesion was not locally controlled in one case and curative treatments were rejected in another case.
  • [MeSH-major] Mandibular Neoplasms / diagnosis. Maxillary Neoplasms / diagnosis. Odontogenic Tumors / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Bone Resorption / diagnosis. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoadjuvant Therapy. Odontogenic Cysts / pathology. Palliative Care. Radiography, Panoramic. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19576790.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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10. Vigneswaran N, Fernandes R, Rodu B, Baughman RA, Siegal GP: Aggressive osteoblastoma of the mandible closely simulating calcifying epithelial odontogenic tumor. Report of two cases with unusual histopathologic findings. Pathol Res Pract; 2001;197(8):569-76
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  • [Title] Aggressive osteoblastoma of the mandible closely simulating calcifying epithelial odontogenic tumor. Report of two cases with unusual histopathologic findings.
  • Aggressive osteoblastoma is a rare bone-forming neoplasm composed of prominent epithelioid cells that demonstrate locally invasive growth with a high rate of recurrence but no metastatic potential.
  • Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy.
  • These tumors were composed of solid sheets of pleomorphic epithelioid cells, eosinophilic amorphous osteoid with foci of calcification, which closely simulated amyloid.
  • Differentiation of this tumor from histologically similar calcifying epithelial odontogenic tumor and low-grade osteosarcoma proved difficult.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Osteoblastoma / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Child. Diagnosis, Differential. Epithelioid Cells / pathology. Female. Humans. Immunohistochemistry. Male. Osteoblasts / pathology. Osteocalcin / analysis. Vimentin / analysis

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  • (PMID = 11518051.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin; 104982-03-8 / Osteocalcin
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11. Kawano K, Ono K, Yada N, Takahashi Y, Kashima K, Yokoyama S, Yanagisawa S: Malignant calcifying epithelial odontogenic tumor of the mandible: report of a case with pulmonary metastasis showing remarkable response to platinum derivatives. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jul;104(1):76-81
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  • [Title] Malignant calcifying epithelial odontogenic tumor of the mandible: report of a case with pulmonary metastasis showing remarkable response to platinum derivatives.
  • We describe a case of CEOT of the mandible, which underwent malignant transformation and developed metastatic tumors of the lung after repeated local recurrence.
  • The primary tumor revealed typical histological features of benign CEOT showing sheets of polyhedral epithelial cells associated with abundant eosinophilic amyloid-like materials.
  • On the other hand, the locally recurrent tumors had malignant features, such as increased nuclear pleomorphism with frequent mitotic figures and vascular invasion of tumor cells, as well as increased proliferative activity assessed by immunostaining for Ki-67.
  • Chemotherapy was carried out against the pulmonary metastatic lesions, which showed a drastic response after 3 courses of intravenous administration of cisplatin (CDDP).
  • To date, a total of 6 courses of CDDP and 6 courses of nedaplatin (CDGP) have been done, and the remaining pulmonary tumors have been dormant.
  • This suggests that platinum derivatives could be a chemotherapeutic agent of choice against this rare tumor.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Lung Neoplasms / drug therapy. Mandibular Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy. Odontogenic Cyst, Calcifying / drug therapy
  • [MeSH-minor] Bone Transplantation. Humans. Male. Mandible / radiography. Mandible / surgery. Middle Aged. Organoplatinum Compounds / therapeutic use

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  • (PMID = 17577547.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 8UQ3W6JXAN / nedaplatin; Q20Q21Q62J / Cisplatin
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12. Ogawa T, Hara K, Kawarai Y, Nishizaki K, Nomiya S, Takeda Y, Akagi H, Kariya S: A case of infantile neuroblastoma with intramucosal metastasis in a paranasal sinus. Int J Pediatr Otorhinolaryngol; 2000 Sep 15;55(1):61-4
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  • His initial treatment included chemotherapy and surgery, with complete response (CR) being achieved at the initial site.
  • A metastatic lesion was found in the right maxillary sinus 32 months after his initial treatment.
  • The results of biopsy were negative and the differential diagnosis from the imaging studies of CT included odontogenic disease, fungal infection, paranasal sinus cyst or hematoma, and benign tumors.
  • The histopathological diagnosis was metastatic neuroblastoma from the adrenal lesion.
  • The local field was irradiated with 20 Gy of linear accelerator (linac) radiation, then the local field was eradicated.
  • Despite further treatment his general condition deteriorated rapidly and he died 24 months after starting treatment.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Maxillary Sinus Neoplasms / secondary. Neuroblastoma / secondary
  • [MeSH-minor] Adrenalectomy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Needle. Child. Combined Modality Therapy. Disease Progression. Fatal Outcome. Humans. Male. Mucous Membrane / pathology. Tomography, X-Ray Computed

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  • (PMID = 10996238.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] IRELAND
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13. Sauk JJ, Nikitakis NG, Scheper MA: Are we on the brink of nonsurgical treatment for ameloblastoma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):68-78
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are we on the brink of nonsurgical treatment for ameloblastoma?
  • OBJECTIVE: Recent identification of altered molecular signaling pathways in neoplasia has begun to elucidate mechanisms of oncogenesis, differentiation, and tumor progression, and to suggest plausible nonsurgical considerations for treatment.
  • Here we review the sonic hedgehog (SHH) and PI3K/Akt/mTOR signaling pathways, their role in ameloblastoma, a locally aggressive odontogenic tumor, and evidence for consideration of therapeutic approaches that target these molecular pathways.
  • RESULTS: The expression of SHH signaling molecules in ameloblastomas at the mRNA and protein levels has intimated that these molecules may play a role in cell proliferation of these tumors.
  • Immunohistochemical analysis has revealed aberrant signaling in the PI3K/Akt/mTOR pathway in ameloblastomas and appears to be a valuable tool for elucidating pathogenesis and aggressiveness, and selecting optimal therapeutics.
  • CONCLUSION: The understanding of altered pathways in ameloblastoma may soon provide nonsurgical options for the treatment of this condition.
  • Thus, tumors that entirely depend on active SHH signaling for survival/growth and maintenance may well be susceptible targets for combined chemotherapy with SHH-specific inhibitors together with PI3K, Akt, or mTOR blocking agents.
  • [MeSH-major] Ameloblastoma / drug therapy. Signal Transduction / drug effects
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Hedgehog Proteins / antagonists & inhibitors. Hedgehog Proteins / physiology. Humans. Intracellular Signaling Peptides and Proteins / antagonists & inhibitors. Intracellular Signaling Peptides and Proteins / physiology. Phosphatidylinositol 3-Kinases / antagonists & inhibitors. Phosphatidylinositol 3-Kinases / physiology. Protein-Serine-Threonine Kinases / antagonists & inhibitors. Protein-Serine-Threonine Kinases / physiology. Proto-Oncogene Proteins c-akt / antagonists & inhibitors. Proto-Oncogene Proteins c-akt / physiology. TOR Serine-Threonine Kinases. Transcription Factors / antagonists & inhibitors. Transcription Factors / physiology

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20418126.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / SHH protein, human; 0 / Transcription Factors; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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14. Egwari LO, Nwokoye NN, Obisesan B, Coker AO, Nwaokorie FO, Savage KO: Bacteriological and clinical evaluation of twelve cases of post-surgical sepsis of odontogenic tumours at a referral centre. East Afr Med J; 2008 Jun;85(6):269-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bacteriological and clinical evaluation of twelve cases of post-surgical sepsis of odontogenic tumours at a referral centre.
  • OBJECTIVE: To determine the bacterial aetiology of sepsis occurring following surgery of odontogenic tumours and assess the effect of prompt and proper antibiotic usage.
  • SUBJECTS: Twelve patients with odontogenic tumours that developed sepsis postoperatively.
  • INTERVENTION: Adequate review of patient's medical history, bacteriological investigations and antibiotic therapy.
  • MAIN OUTCOME MEASURES: Bacteriological and clinical cure following antibiotic therapy based on susceptibility test results.
  • Sepsis developed in the non-compliance group much earlier than in the group that complied (p<0.001).
  • Clostridium perfringens was isolated from a case of osteosarcoma with necrotic tissues.
  • Over 92% of the streptococci were sensitive to the beta-Lactams contrast low susceptibility with S. aureus and K. pneumoniae.
  • [MeSH-major] Odontogenic Tumors / surgery. Patient Compliance. Postoperative Complications. Sepsis / drug therapy. Sepsis / microbiology
  • [MeSH-minor] Anti-Bacterial Agents / pharmacology. Anti-Bacterial Agents / therapeutic use. Bacteria / drug effects. Bacteria / isolation & purification. Drug Resistance, Bacterial. Humans. Nigeria / epidemiology. Prospective Studies. Referral and Consultation

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  • (PMID = 18817023.001).
  • [ISSN] 0012-835X
  • [Journal-full-title] East African medical journal
  • [ISO-abbreviation] East Afr Med J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Kenya
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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