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1. Meyer F, Bairati I, Jobin E, Gélinas M, Fortin A, Nabid A, Têtu B: Acute adverse effects of radiation therapy and local recurrence in relation to dietary and plasma beta carotene and alpha tocopherol in head and neck cancer patients. Nutr Cancer; 2007;59(1):29-35
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  • [Title] Acute adverse effects of radiation therapy and local recurrence in relation to dietary and plasma beta carotene and alpha tocopherol in head and neck cancer patients.
  • There is a debate concerning the effects of antioxidant vitamins during radiation therapy: Can they reduce the adverse effects of therapy without reducing treatment efficacy?
  • We examined whether dietary and plasma beta carotene and alpha tocopherol were related to severe acute adverse effects of radiation therapy and to cancer local recurrence.
  • We conducted a prospective study of 540 head and neck cancer patients treated by radiation therapy.
  • Acute adverse effects of radiation therapy and local recurrence were documented.
  • Alpha tocopherol was not related to severe adverse effects or to cancer recurrence.
  • This study suggests that a higher usual dietary beta carotene intake can reduce the occurrence of severe adverse effects of radiation therapy and decrease local cancer recurrence.
  • [MeSH-major] Head and Neck Neoplasms / drug therapy. Radiation Injuries / prevention & control. alpha-Tocopherol / blood. alpha-Tocopherol / therapeutic use. beta Carotene / blood. beta Carotene / therapeutic use
  • [MeSH-minor] Antioxidants / metabolism. Antioxidants / therapeutic use. Confidence Intervals. Diet. Dietary Supplements. Double-Blind Method. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Odds Ratio. Prospective Studies. Surveys and Questionnaires

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  • (PMID = 17927499.001).
  • [ISSN] 0163-5581
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 01YAE03M7J / beta Carotene; H4N855PNZ1 / alpha-Tocopherol
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2. Schmelz EM, Xu H, Sengupta R, Du J, Banerjee S, Sarkar FH, Rishi AK, Majumdar AP: Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein. Cancer Res; 2007 Jun 1;67(11):5389-96
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  • [Title] Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein.
  • A role of the epidermal growth factor receptor (EGFR) family has been suggested in colon cancer etiology, progression, and/or severity.
  • Our recently identified pan-erbB inhibitor EGFR-related protein (ERRP) targets EGFRs by attenuating their activation and subsequent signaling leading to cellular growth inhibition.
  • In the present study, we evaluated the therapeutic effectiveness of ERRP on early and intermediate stages of colon cancer by examining regression of chemically induced aberrant crypt foci (ACF) in the colon of CF1 mice and intestinal adenomas in APC(Min+/-) (Min) mice.
  • This treatment significantly reduced the number of ACF from 25.0 +/- 3.0 (controls) to 14.9 +/- 1.6 (ERRP-treated; P = 0.011) and also reduced their size (P < 0.01).
  • In conclusion, our data show that ERRP is effective in regressing both early and intermediate intestinal lesions and could be an effective therapeutic agent for colon cancer.
  • [MeSH-major] Colonic Neoplasms / drug therapy. Drosophila Proteins / pharmacology. Receptor, Epidermal Growth Factor / antagonists & inhibitors
  • [MeSH-minor] 1,2-Dimethylhydrazine. Adenoma / chemically induced. Adenoma / drug therapy. Adenoma / metabolism. Adenoma / pathology. Animals. Apoptosis / drug effects. Carcinogens. Cell Growth Processes / drug effects. Female. Intestinal Mucosa / drug effects. Intestinal Mucosa / metabolism. Male. Mice. Mice, Inbred C57BL. NF-kappa B / antagonists & inhibitors. NF-kappa B / metabolism. Neoplasm Staging. Precancerous Conditions / chemically induced. Precancerous Conditions / drug therapy. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Receptors, Estrogen / genetics. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / pharmacology. Transforming Growth Factor alpha / metabolism

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  • (PMID = 17545620.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01 AG014343
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Drosophila Proteins; 0 / ERR protein, Drosophila; 0 / NF-kappa B; 0 / Receptors, Estrogen; 0 / Recombinant Fusion Proteins; 0 / Transforming Growth Factor alpha; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; IX068S9745 / 1,2-Dimethylhydrazine
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3. Couluris M, Mayer JL, Freyer DR, Sandler E, Xu P, Krischer JP: The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. J Pediatr Hematol Oncol; 2008 Nov;30(11):791-7
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  • [Title] The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
  • BACKGROUND: Children with cancer frequently have associated cachexia and malnutrition.
  • Appetite stimulation and increased food intake is 1 approach to combat cancer-related cachexia.
  • MATERIALS AND METHODS: Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss.
  • One patient on MA developed low cortisol levels and hyperlipidemia.
  • CONCLUSIONS: This study demonstrates that CH is a safe and effective way to promote weight gain in children with cancer/treatment-related cachexia.

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  • (PMID = 18989154.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA098543-06; United States / NCI NIH HHS / CA / U10 CA81920; United States / NCI NIH HHS / CA / U10 CA081920; United States / NCI NIH HHS / CA / U10 CA098543; None / None / / U10 CA098543-06
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Appetite Stimulants; 0 / Gastrointestinal Agents; 2YHB6175DO / Cyproheptadine; TJ2M0FR8ES / Megestrol Acetate
  • [Other-IDs] NLM/ NIHMS184870; NLM/ PMC2917791
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4. Calviello G, Serini S, Piccioni E: n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved. Curr Med Chem; 2007;14(29):3059-69
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  • [Title] n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved.
  • Increasing evidence supports the hypothesis that nutrition habits play a critical role in the incidence and growth of colorectal cancer.
  • Among dietary factors, fish-derived n-3 polyunsaturated fatty acids (PUFAs) have gained particular interest, since epidemiological studies have shown a reduced incidence of this cancer in populations consuming high levels of fish.
  • Such an anti-neoplastic activity has been related to the regulatory effects exhibited by n-3 PUFAs on cell proliferation and apoptosis.
  • Finally, it has been suggested that they may act as adjuvant therapeutic agents sensitizing tumors, including colon cancer, to different anti-neoplastic drugs.
  • Their inhibitory action has been also recently suggested for the molecular pathways driven by COX-2 and beta-catenin, known to play a major role in the development and progression of colon cancer.
  • The aim of the present review is to analyze the anti-neoplastic effect of n-3 PUFAs towards colon cancer, and examine the molecular mechanisms involved.
  • [MeSH-major] Colorectal Neoplasms / prevention & control. Fatty Acids, Omega-3 / therapeutic use. beta Catenin / metabolism
  • [MeSH-minor] Animals. Antineoplastic Agents / therapeutic use. Apoptosis / drug effects. Cell Membrane Structures / physiology. Cyclooxygenase 2 / metabolism. Humans. Inflammatory Bowel Diseases / metabolism. Neoplasm Metastasis / drug therapy. Neoplasm Metastasis / prevention & control. Neovascularization, Pathologic / prevention & control. Oxidative Stress. Vascular Endothelial Growth Factor A / antagonists & inhibitors. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 18220742.001).
  • [ISSN] 0929-8673
  • [Journal-full-title] Current medicinal chemistry
  • [ISO-abbreviation] Curr. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Fatty Acids, Omega-3; 0 / Vascular Endothelial Growth Factor A; 0 / beta Catenin; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
  • [Number-of-references] 187
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5. Iguchi H, Aramaki Y, Maruta S, Takiguchi S: Effects of anti-parathyroid hormone-related protein monoclonal antibody and osteoprotegerin on PTHrP-producing tumor-induced cachexia in nude mice. J Bone Miner Metab; 2006;24(1):16-9
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  • [Title] Effects of anti-parathyroid hormone-related protein monoclonal antibody and osteoprotegerin on PTHrP-producing tumor-induced cachexia in nude mice.
  • We have previously demonstrated that parathyroid hormone-related protein (PTHrP) is a cachexia inducer, but it is still not known what PTHrP effects on target tissues induce the cachexia.
  • Nude mice bearing PTHrP-producing human lung cancer cells (HARA-B) exhibited cachexia with hypercalcemia 3-4 weeks after inoculation, accompanied by losses in body, adipose tissue, and muscle weight.
  • OPG ameliorated hypercalcemia, as did neutralization of PTHrP with antibody; and it increased both body and adipose tissue weights.
  • These increases in body and adipose tissue weight, however, were significantly less than those in mice treated with anti-PTHrP antibody.
  • Simultaneous administration of OPG and anti-PTHrP antibody caused significant increases in body, adipose tissue, and muscle weight, along with an immediate decrease in blood ionized calcium levels.
  • These results suggest that an effect of PTHrP on target tissues other than hypercalcemia is involved in the development of cachexia.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Cachexia / drug therapy. Glycoproteins / therapeutic use. Parathyroid Hormone-Related Protein / immunology. Receptors, Cytoplasmic and Nuclear / therapeutic use. Receptors, Tumor Necrosis Factor / therapeutic use
  • [MeSH-minor] Animals. Body Weight / drug effects. Disease Models, Animal. Humans. Hypercalcemia / drug therapy. Hypercalcemia / etiology. Lung Neoplasms / complications. Mice. Mice, Nude. Neoplasm Transplantation. Osteoprotegerin. Tumor Cells, Cultured

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  • (PMID = 16369893.001).
  • [ISSN] 0914-8779
  • [Journal-full-title] Journal of bone and mineral metabolism
  • [ISO-abbreviation] J. Bone Miner. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Glycoproteins; 0 / Osteoprotegerin; 0 / Parathyroid Hormone-Related Protein; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Receptors, Tumor Necrosis Factor; 0 / TNFRSF11B protein, human; 0 / Tnfrsf11b protein, mouse
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6. Gerardi MA, Santillan A, Meisner B, Zahurak ML, Diaz Montes TP, Giuntoli RL 2nd, Bristow RE: A clinical pathway for patients undergoing primary cytoreductive surgery with rectosigmoid colectomy for advanced ovarian and primary peritoneal cancers. Gynecol Oncol; 2008 Feb;108(2):282-6
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  • Critical elements of the clinical pathway included: rapid diet advancement, early discontinuance of nasogastric suction, criteria-based utilization of parenteral nutrition, selective laboratory testing, and deferring initiation of chemotherapy until after discharge.
  • The median time to flatus was 6 days for both groups (p=0.95); however, the median time to tolerance of diet was 3 days for Group A and 6 days for Group B (p=0.013).
  • CONCLUSIONS: A critical pathway incorporating rapid diet advancement for patients undergoing primary cytoreductive surgery with rectosigmoid colectomy for ovarian and primary peritoneal cancers is feasible, safe, and associated with a significant reduction in length of hospital stay and hospital-related costs.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Diet. Female. Humans. Intubation, Gastrointestinal. Middle Aged. Neoplasm Staging. Postoperative Care / methods

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  • (PMID = 18023851.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Kieback DG, Einzmann T, Labinsky E, Fischer DC, Niebergall H, Hasenburg A: Aggressive management of recurrent ovarian cancer--the challenge of individualizing cancer therapy illustrated by a case report. Onkologie; 2004 Aug;27(4):393-7
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  • [Title] Aggressive management of recurrent ovarian cancer--the challenge of individualizing cancer therapy illustrated by a case report.
  • BACKGROUND: In clinical practice, treatment recommendations and the patient's wishes often diverge, facing the physician with difficult choices.
  • CASE REPORT: The clinical course of a 36-year-old patient with 'platinum-refractory' ovarian cancer is reported.
  • The patient experienced a symptomatic relapse 7 months after debulking surgery and completion of platinum-based first-line chemotherapy.
  • Her husband supported her, and both asked for maximal therapy, including intensive care treatment for recurrent respiratory tract infections and total parenteral nutrition (TPN).
  • Problems related to TPN and progression of disease affected her individual perception of quality of life to a much lower extent than expected and perceived by her caretakers.
  • All professional health care providers were more than once very reluctant to continue treatment and only after extensive counseling gave in to the demand of the patient for further treatment, considering the effort futile - only to be surprised by treatment response and recovery.
  • After 3 years of palliation, the tumor was resistant to all cytotoxic regimens and the patient died 2 months after withdrawal of chemotherapy.
  • CONCLUSION: This case report illustrates that also in the age of evidence-based medicine individualized treatment beyond proven strategies can offer patient benefit.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Papillary / drug therapy. Neoplasm Recurrence, Local / drug therapy. Ovarian Neoplasms / drug therapy. Palliative Care / methods. Patient Participation. Puerperal Disorders / drug therapy
  • [MeSH-minor] Adult. Critical Care / psychology. Dose-Response Relationship, Drug. Drug Administration Schedule. Drug Resistance, Neoplasm. Female. Humans. Medical Futility. Motivation. Parenteral Nutrition, Total / psychology. Quality of Life / psychology


8. Lee LT, Schally AV, Liebow C, Lee PP, Lee PH, Lee MT: Dephosphorylation of cancer protein by tyrosine phosphatases in response to analogs of luteinizing hormone-releasing hormone and somatostatin. Anticancer Res; 2008 Sep-Oct;28(5A):2599-605
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  • [Title] Dephosphorylation of cancer protein by tyrosine phosphatases in response to analogs of luteinizing hormone-releasing hormone and somatostatin.
  • The homology of substrate phosphorylation between induced PTK and PTP in the presence of hormones provided evidence that these substrates might be identical or related in tumors.
  • These findings, along with the previous cell culture results, suggest that many solid tumors may respond to treatment with analogues of somatostatin and LHRH.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Neoplasm Proteins / metabolism. Neoplasms / metabolism. Protein Tyrosine Phosphatases / metabolism. Somatostatin / analogs & derivatives. Triptorelin Pamoate / pharmacology
  • [MeSH-minor] Antineoplastic Agents, Hormonal / pharmacology. Breast Neoplasms / drug therapy. Breast Neoplasms / enzymology. Breast Neoplasms / metabolism. Epidermal Growth Factor / pharmacology. Female. Humans. Liver Neoplasms / drug therapy. Liver Neoplasms / enzymology. Liver Neoplasms / metabolism. Male. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / enzymology. Ovarian Neoplasms / metabolism. Phosphorylation. Prostatic Neoplasms / drug therapy. Prostatic Neoplasms / enzymology. Prostatic Neoplasms / metabolism

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  • (PMID = 19035284.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Hormonal; 0 / Neoplasm Proteins; 2PK59M9GFF / vapreotide; 51110-01-1 / Somatostatin; 57773-63-4 / Triptorelin Pamoate; 62229-50-9 / Epidermal Growth Factor; EC 3.1.3.48 / Protein Tyrosine Phosphatases
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9. Theobald S: [Nutrition and prostate cancer--what is the scientific evidence?]. Med Monatsschr Pharm; 2006 Oct;29(10):371-7
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  • [Title] [Nutrition and prostate cancer--what is the scientific evidence?].
  • Prostate cancer is the most frequently occurring form of cancer in German men with an incidence of 49.000 in the year 2002.
  • Among individual food groups/nutrients a high consumption of total fat, saturated fats, meat, dairy, and calcium are related to an increased risk.
  • Tomato products, soy, lycopene, selenium, marine omega-3-fatty acids and vitamin E in smokers may inversely be associated with prostate cancer.
  • Evidence from experimental studies and clinical experience suggest that application of selenium during chemotherapy and/or radiotherapy may decrease therapy related toxicities and increases the effect of the standard therapy on cancer cells.
  • For expert patients it is essential to participate in decisions concerning their standard as well as complementary therapy by developing individual self-help concepts.
  • Physicians should consider these needs when they counsel cancer patients.
  • [MeSH-minor] Diet. Humans. Male. Neoplasm Recurrence, Local / prevention & control. Selenium / therapeutic use

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  • (PMID = 17058896.001).
  • [ISSN] 0342-9601
  • [Journal-full-title] Medizinische Monatsschrift für Pharmazeuten
  • [ISO-abbreviation] Med Monatsschr Pharm
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] H6241UJ22B / Selenium
  • [Number-of-references] 0
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10. Lee WY, Huang SC, Tzeng CC, Chang TL, Hsu KF: Alterations of metastasis-related genes identified using an oligonucleotide microarray of genistein-treated HCC1395 breast cancer cells. Nutr Cancer; 2007;58(2):239-46
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  • [Title] Alterations of metastasis-related genes identified using an oligonucleotide microarray of genistein-treated HCC1395 breast cancer cells.
  • Genistein, one of the major isoflavones, potently inhibits the growth and metastasis of breast cancer.
  • We investigated the effect of genistein in HCC1395 cells, a cell line derived from an early-stage primary breast cancer.
  • We used human oligonucleotide microarrays to determine the gene expression profile altered by genistein treatment.
  • We used quantitative real-time polymerase chain reaction to verify the microarray data at the mRNA level.
  • We conclude that genistein-induced alternations of gene expression involving metastasis may be exploited for devising chemopreventive and therapeutic strategies, particularly for early-stage breast cancer.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Breast Neoplasms / drug therapy. Gene Expression Regulation, Neoplastic / drug effects. Genistein / pharmacology. Oligonucleotide Array Sequence Analysis / methods
  • [MeSH-minor] Cell Survival / drug effects. Dose-Response Relationship, Drug. Down-Regulation / drug effects. Female. Flow Cytometry. Gene Expression Profiling. Humans. Neoplasm Invasiveness. Neoplasm Metastasis / drug therapy. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 17640171.001).
  • [ISSN] 0163-5581
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; DH2M523P0H / Genistein
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11. Ramos-De la Medina A, Salgado-Nesme N, Torres-Villalobos G, Medina-Franco H: Clinicopathologic characteristics of gastric cancer in a young patient population. J Gastrointest Surg; 2004 Mar-Apr;8(3):240-4
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  • [Title] Clinicopathologic characteristics of gastric cancer in a young patient population.
  • The aim of this study was to analyze the clinicopathologic characteristics of young patients with gastric cancer with special attention to hereditary gastric cancer in a tertiary referral university hospital.
  • Charts from all patients 40 years of age or younger at the time of diagnosis, during the period from January 1, 1987 to December 31, 2001, were retrospectively reviewed.
  • Demographic variables, family history of gastric cancer, clinicopathologic characteristics, and treatment-related variables were analyzed.
  • During the study period, 558 cases of gastric cancer were seen at our institution, 83 (14.8%) were in patients 40 years of age or younger.
  • Fourteen patients (16.9%) had a family history of gastric cancer.
  • Five patients (6%) fulfilled the criteria of hereditary gastric cancer.
  • On univariate analysis, advanced tumor stage, hypoalbuminemia, low performance status, diffuse type, pangastric tumor location, noncurative surgery, and lack of adjuvant chemotherapy had a significant negative impact on survival.
  • On multivariate analysis, advanced tumor stage, pangastric tumor location, and absence of adjuvant chemotherapy were significantly associated with poor prognosis.
  • Family history of gastric cancer or hereditary gastric cancer did not have any impact on prognosis.
  • There is a high frequency of gastric cancer in young patients at our institution.
  • Family history of gastric cancer or hereditary gastric cancer did not have a significant impact on survival.
  • Complete resection and adjuvant chemotherapy appeared to confer the only chance of prolonged survival.
  • [MeSH-minor] Adult. Cadherins / genetics. Female. Humans. Male. Mexico / epidemiology. Multivariate Analysis. Neoplasm Staging. Retrospective Studies. Stomach / pathology. Survival Rate

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  • (PMID = 15019915.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
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12. Cabrera R, Nelson DR: Review article: the management of hepatocellular carcinoma. Aliment Pharmacol Ther; 2010 Feb 15;31(4):461-76
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  • The Barcelona Clinic Liver Cancer staging classification system is a clinically useful algorithm for the management of patients with hepatocellular carcinoma.
  • The simultaneous presence of cirrhosis in the patients complicates their management and monitoring for cirrhosis-related complications is important.
  • CONCLUSIONS: Early diagnosis and definitive treatment remains the key to long-term outcome.
  • Studies combining sorafenib with locoregional or other targeted molecular therapies are likely to improve responses and outcome.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Benzenesulfonates / therapeutic use. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / therapy. Liver Neoplasms / diagnosis. Liver Neoplasms / therapy. Pyridines / therapeutic use
  • [MeSH-minor] Ablation Techniques. Adult. African Continental Ancestry Group. Asian Continental Ancestry Group. Biopsy. Chemoembolization, Therapeutic. Contrast Media. Drug Eruptions / prevention & control. Female. Health Care Costs. Hepatitis B, Chronic / complications. Hepatitis B, Chronic / epidemiology. Hepatitis C, Chronic / complications. Hepatitis C, Chronic / epidemiology. Humans. Incidence. Liver Cirrhosis / complications. Liver Cirrhosis / mortality. Liver Transplantation. Male. Middle Aged. Neoplasm Staging / methods. Neovascularization, Pathologic / drug therapy. Niacinamide / analogs & derivatives. Phenylurea Compounds. Population Surveillance. Practice Guidelines as Topic. Quality of Life. Randomized Controlled Trials as Topic. Recurrence. Risk Factors. Survival Rate. Tomography, X-Ray Computed. Treatment Outcome. United States / epidemiology. Young Adult

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  • [CommentIn] Aliment Pharmacol Ther. 2010 May;31(10):1153-4 [20518755.001]
  • (PMID = 19925500.001).
  • [ISSN] 1365-2036
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Contrast Media; 0 / Phenylurea Compounds; 0 / Pyridines; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib
  • [Number-of-references] 96
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13. Yamazaki K, Boku N, Shibamoto K, Yasui H, Fukutomi A, Yoshino T, Hironaka S, Onozawa Y, Otake Y, Hasuike N, Matsubayashi H, Inui T, Yamaguchi Y, Ono H: The role of the outpatient clinic in chemotherapy for patients with unresectable or recurrent gastric cancer. Jpn J Clin Oncol; 2007 Feb;37(2):96-101
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  • [Title] The role of the outpatient clinic in chemotherapy for patients with unresectable or recurrent gastric cancer.
  • BACKGROUND: Recently, outpatient chemotherapy centers have become popular in Japan.
  • To clarify the actual conditions of outpatient clinics, we surveyed entire clinical courses of chemotherapy in patients with unresectable or recurrent gastric cancer.
  • METHODS: From the medical records of 64 patients with unresectable or recurrent gastric cancer with no prior chemotherapy, we obtained data on overall survival, non-hospitalized survival, the number of and reasons for attendance at the outpatient clinic and hospitalization, and medical conditions at discharge.
  • RESULTS: The median follow-up time was 520 days, the median survival time was 353 days, and the median non-hospitalized survival time was 282 days.
  • Patients attended the outpatient clinic 1917 times in total; 145 (8%) of these were unplanned visits for accidental disease, disease progression, or toxicity.
  • Patients were hospitalized 291 times in total: 110 (38%) of hospitalizations were unplanned or emergencies because of disease progression or toxicity.
  • Patients were discharged 290 times in total; in 56 of these discharges (19%) unresolved medical problems remained, such as toxicity, total parenteral nutrition, or symptoms related to cancer.
  • Three patients (5%) died from treatment-related leucopenia and thrombocytopenia.
  • CONCLUSIONS: Patients with unresectable and recurrent gastric cancer were treated at outpatient clinics for periods up to 80% longer than the entire clinical course of chemotherapy.
  • The role of the outpatient clinic is very important to chemotherapy for patients with unresectable or recurrent gastric cancer.
  • [MeSH-major] Ambulatory Care Facilities. Antineoplastic Agents / administration & dosage. Cancer Care Facilities. Stomach Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Emergency Medical Services. Female. Hospitalization / statistics & numerical data. Humans. Japan. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Retrospective Studies. Survival Analysis

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  • (PMID = 17272316.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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14. Laubach JP, Mitsiades CS, Roccaro AM, Ghobrial IM, Anderson KC, Richardson PG: Clinical challenges associated with bortezomib therapy in multiple myeloma and Waldenströms Macroglobulinemia. Leuk Lymphoma; 2009 May;50(5):694-702
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  • [Title] Clinical challenges associated with bortezomib therapy in multiple myeloma and Waldenströms Macroglobulinemia.
  • Optimization of bortezomib-based therapy, though, requires an understanding of the various challenges associated with use of the drug.
  • This review highlights the rationale for bortezomib therapy in patients with multiple myeloma and Waldenströms Macroglobulinemia, mechanisms of bortezomib resistance, important therapy-related side effects, and new directions for the use of proteasome inhibitors in these disorders.

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  • (PMID = 19452315.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA126119-02; United States / NCI NIH HHS / CA / R21 CA126119; United States / NCI NIH HHS / CA / R21 CA126119-02
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Boronic Acids; 0 / Protease Inhibitors; 0 / Pyrazines; 69G8BD63PP / Bortezomib
  • [Number-of-references] 68
  • [Other-IDs] NLM/ NIHMS304905; NLM/ PMC3133638
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15. Brard L, Weitzen S, Strubel-Lagan SL, Swamy N, Gordinier ME, Moore RG, Granai CO: The effect of total parenteral nutrition on the survival of terminally ill ovarian cancer patients. Gynecol Oncol; 2006 Oct;103(1):176-80
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  • [Title] The effect of total parenteral nutrition on the survival of terminally ill ovarian cancer patients.
  • OBJECTIVES: Total parenteral nutrition (TPN) for terminal ovarian cancer patients remains controversial.
  • In this study, we compared survival from time of terminal intestinal obstruction (TIO) diagnosis in patients who received TPN versus those who did not.
  • METHODS: A historical cohort of 55 patients with stage IIIC/IV epithelial ovarian cancer hospitalized for TIO between 1994 and 2002 was studied.
  • Number of chemotherapy cycles completed after TIO diagnosis, major complications of TPN, and demographics were measured.
  • RESULTS: The median survival from time of TIO diagnosis was 72 days (range 16-485) for patients receiving TPN and 41.0 days (range 4-133) for those not receiving TPN (P = 0.05), but no difference in survival was observed when adjusting for chemotherapy.
  • Patients receiving TPN after obstruction were more likely to undergo concurrent chemotherapy (64 vs. 26%, P = 0.004).
  • One major TPN-related complication was found.
  • CONCLUSIONS: Ovarian cancer patients with TIO receiving TPN had a median survival benefit of 4 weeks.
  • This benefit decreased when patients were treated with concurrent chemotherapy.
  • [MeSH-major] Intestinal Obstruction / therapy. Ovarian Neoplasms / therapy. Parenteral Nutrition, Total
  • [MeSH-minor] Cohort Studies. Epithelial Cells / pathology. Female. Humans. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate. Terminal Care


16. Chatni SS, Sainani RS, Mehta SA, Mohandas KM: Infusion chemotherapy with cisplatinum and fluorouracil in the treatment of locally-advanced and metastatic gallbladder cancer. J Cancer Res Ther; 2008 Oct-Dec;4(4):151-5
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  • [Title] Infusion chemotherapy with cisplatinum and fluorouracil in the treatment of locally-advanced and metastatic gallbladder cancer.
  • BACKGROUND: Gallbladder cancer (GBC) has a poor prognosis.
  • Chemotherapy is traditionally considered to be ineffective.
  • MATERIALS AND METHODS: A total of 65 patients with inoperable GBC received palliative chemotherapy with CDDP and 5-FU.
  • Response was assessed after three cycles of chemotherapy.
  • RESULTS: A total of 19 patients had locally advanced unresectable cancer and 46 patients had metastatic cancer.
  • A total of 212 chemotherapy cycles were administered to the patients.
  • Response evaluation after three cycles of chemotherapy revealed complete response in five patients [7.69%; 95% confidence interval (95% CI): 2.87-16.22], partial response in 17 patients (26.15%; 95% CI: 16.57-37.81), stabilization of disease in 9 patients (13.85%; 95% CI: 6.96-23.88), and progression in 21 patients (32.30%; 95% CI: 21.80-44.35).
  • The median overall survival was 5.7 months and the median time to disease progression was 3.1 months.
  • This chemotherapy combination was well tolerated.
  • There were no chemotherapy-related deaths.
  • CONCLUSIONS: Infusion chemotherapy with CDDP and 5-FU appears to have a fair amount of activity in patients of inoperable GBC, with acceptable toxicity.
  • Tumor shrinkage following treatment with this regimen enabled surgical resection in two patients.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Fluorouracil / administration & dosage. Gallbladder Neoplasms / drug therapy. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis. Prospective Studies. Treatment Outcome

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  • (PMID = 19052386.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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17. Unek IT, Celtik A, Alacacioğlu A, Cokmert S, Yavuzşen T, Doğan NS, Oztop I, Demirkan B, Yilmaz U: Gastric carcinoma during pregnancy: report of a case. Turk J Gastroenterol; 2007 Mar;18(1):41-3
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  • BACKGROUND/AIMS: Gastric cancer in pregnancy is extremely rare and often diagnosed at advanced stages.
  • Well-recognized pregnancy-related symptoms, such as nausea and epigastric discomfort, can be the first symptoms of gastric cancer.
  • Thus, the diagnosis of gastric cancer in pregnancy is difficult.
  • We herein report a case of gastric cancer in pregnancy to alert clinicians to this rare possibility.
  • Gastroscopy demonstrated a tumor originating from the cardia and invading throughout the distal corpus.
  • An explorative laparotomy revealed an unresectable gastric cancer and multiple peritoneal implants.
  • She was admitted to the medical oncology clinic and received a palliative chemotherapy.
  • A nasogastric tube was inserted for intestinal decompression, and total parenteral nutrition was administered.
  • An adequate pain medication was given.
  • CONCLUSION: Early diagnosis of gastric cancer is very important for a better outcome.
  • [MeSH-minor] Abdominal Pain / etiology. Abortion, Therapeutic. Adult. Antineoplastic Agents / therapeutic use. Ascites. Female. Humans. Neoplasm Invasiveness. Palliative Care. Pregnancy

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  • (PMID = 17450494.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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18. Dupertuis YM, Xiao WH, De Tribolet N, Pichard C, Slosman DO, Bischof Delaloye A, Buchegger F: Unlabelled iododeoxyuridine increases the rate of uptake of [125I]iododeoxyuridine in human xenografted glioblastomas. Eur J Nucl Med Mol Imaging; 2002 Apr;29(4):499-505
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  • 5-Iodo-2'-deoxyuridine (IdUrd), a thymidine (TdR) analogue, can be radiolabelled with iodine-125, an Auger radiation emitter, to provoke double-strand breaks once incorporated into DNA of cancer cells.
  • The rate of uptake of [125I]IdUrd in normal rapidly dividing tissues was also increased by 1.3- to 2.8-fold.
  • TdR completely blocked [125I]IdUrd uptake in tumours and tissues.
  • Analogues of IdUrd, such as deoxyuridine and 5-iodo-1,3-dimethyuracil, did not reproduce the effect of IdUrd on the uptake of [125I]IdUrd, suggesting that it is not related to protection against [125I]IdUrd degradation.
  • It is concluded that combined administration of unlabelled IdUrd may improve the use of radiolabelled IdUrd for cancer diagnosis or therapy.
  • [MeSH-major] DNA, Neoplasm / metabolism. Glioblastoma / metabolism. Idoxuridine / pharmacology. Iodine Radioisotopes / pharmacokinetics. Nucleic Acid Synthesis Inhibitors / pharmacology
  • [MeSH-minor] Animals. Cell Cycle / drug effects. Disease Models, Animal. Humans. In Vitro Techniques. Mice. Mice, Nude. Reference Values. Reproducibility of Results. Sensitivity and Specificity. Tissue Distribution. Transplantation, Heterologous. Tumor Cells, Cultured / metabolism. Xenograft Model Antitumor Assays / methods

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  • (PMID = 11914888.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Iodine Radioisotopes; 0 / Nucleic Acid Synthesis Inhibitors; LGP81V5245 / Idoxuridine
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19. Ramos S: Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res; 2008 May;52(5):507-26
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  • [Title] Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways.
  • Prevention of cancer through dietary intervention recently has received an increasing interest, and dietary polyphenols have become not only important potential chemopreventive, but also therapeutic, natural agents.
  • Polyphenols have been reported to interfere at the initiation, promotion and progression of cancer.
  • They might lead to the modulation of proteins in diverse pathways and require the integration of different signals for the final chemopreventive or therapeutic effect.
  • Polyphenols have been demonstrated to act on multiple key elements in signal transduction pathways related to cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis and metastasis; however, these molecular mechanisms of action are not completely characterized and many features remain to be elucidated.
  • The aim of this review is to provide insights into the molecular basis of potential chemopreventive and therapeutic activities of dietary polyphenols with emphasis in their ability to control intracellular signalling cascades considered as relevant targets in a cancer preventive approach.
  • [MeSH-major] Anticarcinogenic Agents / therapeutic use. Antineoplastic Agents / therapeutic use. Chemoprevention / methods. Flavonoids / therapeutic use. Neoplasms / drug therapy. Phenols / therapeutic use
  • [MeSH-minor] Apoptosis / drug effects. Diet. Fruit. Humans. Neoplasm Metastasis / prevention & control. Polyphenols. Signal Transduction. Vegetables

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  • (PMID = 18435439.001).
  • [ISSN] 1613-4133
  • [Journal-full-title] Molecular nutrition & food research
  • [ISO-abbreviation] Mol Nutr Food Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Antineoplastic Agents; 0 / Flavonoids; 0 / Phenols; 0 / Polyphenols
  • [Number-of-references] 179
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20. Thivat E, Thérondel S, Lapirot O, Abrial C, Gimbergues P, Gadéa E, Planchat E, Kwiatkowski F, Mouret-Reynier MA, Chollet P, Durando X: Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse. BMC Cancer; 2010;10:648
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  • [Title] Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse.
  • BACKGROUND: Weight change during chemotherapy is reported to be associated with a worse prognosis in breast cancer patients, both with weight gain and weight loss.
  • However, most studies were conducted prior to the common use of anthracycline-base chemotherapy and on North American populations with a mean BMI classified as overweight.
  • Our study was aimed to evaluate the prognostic value of weight change during anthracycline-based chemotherapy on non metastatic breast cancer (European population) with a long term follow-up.
  • METHODS: Patients included 111 women diagnosed with early stage breast cancer and locally advanced breast cancer who have been treated by anthracycline-based chemotherapy regimen between 1976 and 1989.
  • The relative percent weight variation (WV) between baseline and postchemotherapy treatment was calculated and categorized into either weight change (WV > 5%) or stable (WV < 5%).
  • Cox proportional hazard models were used to evaluate any potential association of weight change and known prognostic factors with the time to recurrence and overall survival.
  • During chemotherapy treatment, 31% of patients presented a notable weight variation which was greater than 5% of their initial weight.In multivariate analyses, weight change (> 5%) was positively associated with an increased risk of both recurrence (RR 2.28; 95% CI: 1.29-4.03) and death (RR 2.11; 95% CI: 1.21-3.66).
  • CONCLUSIONS: Our results suggest that weight change during breast-cancer chemotherapy treatment may be related to poorer prognosis with higher recurrence and higher mortality in comparison to women who maintained their weight.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / drug therapy. Weight Gain. Weight Loss
  • [MeSH-minor] Adult. Anthracyclines / administration & dosage. Body Mass Index. Chi-Square Distribution. Disease-Free Survival. Female. France. Humans. Kaplan-Meier Estimate. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Risk Factors. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 21108799.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthracyclines
  • [Other-IDs] NLM/ PMC3006393
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21. Jenkinson AD, Lim J, Agrawal N, Menzies D: Laparoscopic feeding jejunostomy in esophagogastric cancer. Surg Endosc; 2007 Feb;21(2):299-302
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  • [Title] Laparoscopic feeding jejunostomy in esophagogastric cancer.
  • BACKGROUND: Patients with esophagogastric malignancies often require nutritional supplementation in the perioperative period, especially in the setting where neoadjuvant therapy may delay tumor resection.
  • A simple technique is described here that can be performed at the time of staging laparoscopy and that has not been described before.
  • RESULTS: Forty-three patients treated over a 4-year period who had a laparoscopic feeding jejunostomy placed at the time of staging laparoscopy were reviewed.
  • Of these, 35 had preoperative chemotherapy according to a modified MRC OEO2 protocol.
  • The mean time to surgery was 10 weeks.
  • There were no conversions to an open procedure, nor were there any laparotomies for tube-related complications.
  • Mean time in the operating room for each procedure was 44 minutes.
  • It facilitates optimization of nutrition in the perioperative period for these patients, especially in those receiving preoperative chemotherapy.
  • [MeSH-major] Enteral Nutrition / methods. Jejunostomy / methods. Laparoscopy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Esophageal Neoplasms / pathology. Esophageal Neoplasms / surgery. Esophagectomy / methods. Female. Follow-Up Studies. Gastrectomy / methods. Humans. Male. Middle Aged. Neoplasm Staging. Nutritional Status. Probability. Retrospective Studies. Risk Assessment. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery. Treatment Outcome. Weight Gain

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  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
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  • [Publication-type] Journal Article
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22. Kim SC: [Surgical management of pancreatic cancer]. Korean J Gastroenterol; 2008 Feb;51(2):89-100
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  • [Title] [Surgical management of pancreatic cancer].
  • Pancreatic cancer is a major problematic concern among all forms of gastrointestinal malignancies because of its poor prognosis.
  • Although significant progress has been made in the surgical treatment in terms of increased resection rate and decreased treatment-related morbidity and mortality, the true survival rate still remains below 5% today.
  • Surgical options for pancreatic cancer are based on the its unique anatomy and physiology, catastrophic tumor biology, experience of surgeon, and status of patients.
  • Four main options exist for the surgical treatment of pancreatic cancer.
  • These include standard "Whipple" pancreaticoduodenectomy (PD), pylorus preserving PD (PPPD), distal pancreatectomy (left-side pancreatectomy), and total pancreatectomy according to the location of tumor.
  • Portal vein involvement by tumor is regarded as an anatomical extension of disease, and en bloc resection of portal vein with tumor is recommended if technically feasible, which is stated in 2002 AJCC tumor staging for pancreatic cancer.
  • In comparison of the survival rates between standard and extended resection of pancreatic head cancer, no significant survival benefit was demonstrated from the prospective reports.
  • PPPD may be superior to standard PD in respect to nutrition and quality of life without any deleterious effect upon long term survival or tumor recurrence.
  • New surgical treatment modalities including modified extended pancreatectomy, neoadjuvant chemotherapy, and radical antegrade modular distal pancreatectomy have been tried to improve the patients' survival.
  • However, early diagnosis and treatment remain as key factors for the cure of pancreatic cancer irrespective of various surgical trials.
  • [MeSH-minor] Humans. Neoplasm Staging. Pancreaticoduodenectomy. Portal Vein / pathology. Portal Vein / surgery. Prognosis. Survival Rate

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  • (PMID = 18349571.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 57
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