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1. Mondal PK, Pal I, Misra S, Biswas S, Bera SP: Rhabdomyosarcoma of nose, nasopharynx and paranasal sinuses. Indian J Otolaryngol Head Neck Surg; 2009 Dec;61(4):317-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rhabdomyosarcoma of nose, nasopharynx and paranasal sinuses.
  • Rhabdomyosarcoma is an aggressive malignant soft tissue tumor that arises from primitive striated muscle cells called rhabdomyoblasts.
  • It is the most common soft tissue malignant tumor in children and accounts for about 7-8% of childhood cancers.
  • This article presents six cases of rhabdomyosarcoma involving the nose, nasopharynx and the paranasal sinuses four of which were treated with a combination of radiotherapy and chemotherapy and two were treated with medial maxillectomy combined with chemotherapy and radiotherapy.

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  • (PMID = 23120658.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450072
  • [Keywords] NOTNLM ; Nasopharynx / Nose / Paranasal sinuses / Rhabdomyosarcoma
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2. Jimbo H, Kamata S, Miura K, Asamoto S, Tada S, Endo T, Masubuchi T, Nakamura N, Fushimi C: Operative management of skull base malignant tumors arising from the nasal cavity and paranasal sinus: recent strategies used in 25 cases. Neurol Med Chir (Tokyo); 2010 Jan;50(1):20-6; discussion 26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Operative management of skull base malignant tumors arising from the nasal cavity and paranasal sinus: recent strategies used in 25 cases.
  • Cancers of the paranasal sinuses and nasal cavity are the most common malignant tumors of the anterior and anterolateral skull base.
  • The treatment of these tumors affecting the skull base is complex due to the significant anatomical features.
  • Using a combination of adjuvant radiation and chemotherapy, we have achieved a 2-year disease-free survival rate of 90% in these cases.
  • We believe that the optimal management of such malignant tumors involves a multimodal and multidisciplinary team approach.
  • Here we present our recent institutional experience and treatment policy employed during the past 3 years.
  • [MeSH-major] Neurosurgical Procedures / methods. Nose Neoplasms / surgery. Paranasal Sinus Neoplasms / surgery. Skull Base / pathology. Skull Base / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy / methods. Cranial Fossa, Middle / anatomy & histology. Cranial Fossa, Middle / pathology. Cranial Fossa, Middle / surgery. Drug Therapy / methods. Drug Therapy / statistics & numerical data. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Orbit / anatomy & histology. Orbit / pathology. Orbit / surgery. Osteotomy / contraindications. Osteotomy / methods. Paranasal Sinuses / anatomy & histology. Paranasal Sinuses / pathology. Paranasal Sinuses / surgery. Patient Care Team. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Radiotherapy, Adjuvant / methods. Radiotherapy, Adjuvant / statistics & numerical data. Reconstructive Surgical Procedures / methods. Retrospective Studies. Survival Rate

  • MedlinePlus Health Information. consumer health - Nasal Cancer.
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  • (PMID = 20098020.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Zagolski O, Dwivedi RC, Subramanian S, Kazi R: Non-Hodgkin's lymphoma of the sino-nasal tract in children. J Cancer Res Ther; 2010 Jan-Mar;6(1):5-10
MedlinePlus Health Information. consumer health - Nasal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-Hodgkin's lymphoma of the sino-nasal tract in children.
  • Childhood head and neck cancers are relatively uncommon.
  • Of all head and neck cancers occurring in children, non-Hodgkin's lymphoma (NHL) is the most common, others being rhabdomyosarcoma and nasopharyngeal carcinoma.
  • These can be of several different types depending on the predominant cell type and histologic appearance, the most common histological variant being diffuse large B-cell lymphoma.
  • In an attempt to simplify the classification and to develop a universally acceptable classification and staging, they have been classified and staged numerous times over the last three decades, adding more confusion to the topic.
  • Clinical presentations vary according to the histological type.
  • The low grade lymphomas present with a nasal cavity or para-nasal sinus mass associated with obstructive symptoms and/or lymphadenopathy, while high grade lymphomas present with aggressive signs and symptoms including non-healing ulcer, epistaxis, septal perforation and bony destruction.
  • The primary treatment consists of chemotherapy and / or radiation therapy, which is able to achieve remission in two-third of the patients, however, prognosis remains poor with cumulative five-year survival rates at about 30% for all the types of sino-nasal NHLs.
  • Newer targeted therapy (monoclonal antibodies) and combination therapies (including stem cells) are currently being tested in order to improve survival rates in these patients.
  • [MeSH-major] Lymphoma, Non-Hodgkin / pathology. Nose Neoplasms / pathology. Paranasal Sinus Diseases / pathology
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Child. Humans. Neoplasm Staging. Prognosis. Radiotherapy

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  • (PMID = 20479539.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 35
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4. Pauloski BR: Rehabilitation of dysphagia following head and neck cancer. Phys Med Rehabil Clin N Am; 2008 Nov;19(4):889-928, x
MedlinePlus Health Information. consumer health - Swallowing Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rehabilitation of dysphagia following head and neck cancer.
  • Patients who have cancers of the oral cavity, pharynx, or larynx may be treated with surgery, radiotherapy, chemotherapy, or a combination of these modalities.
  • Each treatment type may have a negative impact on posttreatment swallowing function; these effects are presented in this article.
  • A number of rehabilitative procedures are available to the clinician to reduce or eliminate swallowing disorders in patients treated for cancer of the head and neck.
  • The various procedures-including postures, maneuvers, modifications to bolus volume and viscosity, range-of-motion exercises, and strengthening exercises-and their efficacy in patients treated for head and neck cancer are discussed.

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  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
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  • (PMID = 18940647.001).
  • [ISSN] 1047-9651
  • [Journal-full-title] Physical medicine and rehabilitation clinics of North America
  • [ISO-abbreviation] Phys Med Rehabil Clin N Am
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / R01DC007659; United States / NIDCD NIH HHS / DC / R01 DC007659-03; United States / NCI NIH HHS / CA / R01CA95576; United States / NCI NIH HHS / CA / CA095576-05; United States / NIDCD NIH HHS / DC / R01 DC007659; United States / NIDCD NIH HHS / DC / DC007659-03; United States / NCI NIH HHS / CA / R01 CA095576; United States / NCI NIH HHS / CA / R01 CA095576-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ NIHMS79126; NLM/ PMC2593402
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5. Inaji H, Komoike Y, Motomura K, Kasugai T, Sawai Y, Koizumi M, Nose T, Koyama H: Breast-conserving treatment after neoadjuvant chemotherapy in large breast cancer. Breast Cancer; 2002;9(1):20-5
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  • [Title] Breast-conserving treatment after neoadjuvant chemotherapy in large breast cancer.
  • Several recent trials have demonstrated that neoadjuvant chemotherapy can allow more patients to successfully undergo breast-conserving treatment (BCT), and does not confer a survival disadvantage compared with standard adjuvant chemotherapy.
  • In addition, the pathological response of primary breast tumors to neoadjuvant chemotherapy appears to be a surrogate marker for patient outcome.
  • In our series, during the period from May 1995 to December 2000, 86 patients with tumors between 3.1 and 6.0 cm in diameter received epirubicin-based neoadjuvant chemotherapy.
  • The margin positive rate was 14.1%(9/64), similar to the rate after BCT for early-stage breast cancers, the largest diameter of which was smaller than 3 cm.
  • At a median follow-up of 30 months, only 3 patients in the BCT group have developed local recurrence; the local recurrence rate appears to be comparable to that after BCT for early stage breast cancers.
  • Long term follow-up is required, however, to establish whether this procedure is a safe alternative to mastectomy for patients with large breast cancers.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Breast Neoplasms / drug therapy. Breast Neoplasms / surgery. Mastectomy, Segmental. Neoadjuvant Therapy
  • [MeSH-minor] Carcinoma, Ductal, Breast / drug therapy. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / surgery. Carcinoma, Intraductal, Noninfiltrating / drug therapy. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Intraductal, Noninfiltrating / surgery. Epirubicin / administration & dosage. Female. Humans. Neoplasm Recurrence, Local

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  • (PMID = 12196717.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 3Z8479ZZ5X / Epirubicin
  • [Number-of-references] 28
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6. Preś K, Pośpiech L, Krecicki T, Nadolska B, Kubacka M, Zatoński T, Jabłonka A, Piechnik-Resler D, Jankowska-Konsur A: [Malignant neoplasm of nose and paranasal sinuses in Lower Silesia in years 1992-2001]. Wiad Lek; 2006;59(11-12):797-800
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  • [Title] [Malignant neoplasm of nose and paranasal sinuses in Lower Silesia in years 1992-2001].
  • Malignant neoplasms of the nose and paranasal sinuses occur rarely but due to late diagnosis and poor treatment effects still remain a serious problem.
  • The aim of the study was the analysis of all nose and paranasal sinus neoplasms treated at Lower Silesia in the years 1992-2001.
  • MATERIAL AND METHODS: In the years 1992-2001 in Lower Silesia region there were 182 patients treated for malignant nose and paranasal sinus tumors.
  • Principal management was combined therapy--surgery with radiotherapy in 84% of the cases.
  • Radiotherapy alone was performed in 8.8% and chemotherapy as palliative treatment in 7.1%.
  • CONCLUSIONS: Unsatisfactory results of treatment are an effect of a high advanced stage of the tumor while diagnosed.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / therapy. Nose Neoplasms / epidemiology. Nose Neoplasms / therapy. Paranasal Sinus Neoplasms / epidemiology. Paranasal Sinus Neoplasms / therapy
  • [MeSH-minor] Disease-Free Survival. Female. Humans. Lymphatic Metastasis. Male. Neoplasm Staging / classification. Nose. Poland / epidemiology. Radiotherapy, Adjuvant. Retrospective Studies. Sex Distribution. Survival Rate

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  • (PMID = 17427494.001).
  • [ISSN] 0043-5147
  • [Journal-full-title] Wiadomości lekarskie (Warsaw, Poland : 1960)
  • [ISO-abbreviation] Wiad. Lek.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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7. LoTempio MM, Wang MB, Sadeghi A: Treatment of advanced oropharyngeal cancers with chemotherapy and radiation. Ear Nose Throat J; 2003 May;82(5):367-70
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  • [Title] Treatment of advanced oropharyngeal cancers with chemotherapy and radiation.
  • We conducted a retrospective chart review of treatment outcomes in 17 adults who had been selected to undergo concomitant chemotherapy and radiation (chemo/XRT) for late-stage oropharyngeal cancers.
  • Nine patients had a primary tumor at the base of the tongue, five had a primary tumor in the tonsillar area, and three had a tumor that affected both sites.
  • Of this group, 15 patients completed one to three cycles of chemo/XRT, and the remaining two died during therapy.
  • At the most recent follow-up, 9 of the 17 patients (52.9%) were documented to still be alive; seven patients had earlier died as a result of their primary tumor or a distant metastasis, and one patient had been lost to follow-up after completing treatment.
  • At study's end, the duration of post-treatment survival ranged from 2 to 36 months (mean: 12.5).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Brachytherapy / methods. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Oropharyngeal Neoplasms / drug therapy. Oropharyngeal Neoplasms / radiotherapy. Palliative Care / methods
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiation Dosage. Retrospective Studies. Risk Assessment. Sampling Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 12789762.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Homma A, Oridate N, Suzuki F, Taki S, Asano T, Yoshida D, Onimaru R, Nishioka T, Shirato H, Fukuda S: Superselective high-dose cisplatin infusion with concomitant radiotherapy in patients with advanced cancer of the nasal cavity and paranasal sinuses: a single institution experience. Cancer; 2009 Oct 15;115(20):4705-14
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  • [Title] Superselective high-dose cisplatin infusion with concomitant radiotherapy in patients with advanced cancer of the nasal cavity and paranasal sinuses: a single institution experience.
  • BACKGROUND: The current study aimed to evaluate the efficacy of superselective high-dose cisplatin infusion with concomitant radiotherapy (RADPLAT) for previously untreated patients with advanced cancer of the nasal cavity and paranasal sinuses.
  • No patient died as a result of treatment toxicity or had a cerebrovascular accident.
  • CONCLUSIONS: Although a single institution experience, the results of the current study suggest that RADPLAT can cure the majority of patients with advanced cancer of the nasal cavity and paranasal sinuses, as well as preserve organs.
  • [MeSH-major] Cisplatin / administration & dosage. Nasal Cavity. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy. Paranasal Sinus Neoplasms / drug therapy. Paranasal Sinus Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy / adverse effects. Disease Progression. Female. Humans. Infusions, Intra-Arterial. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Survival Analysis. Thiosulfates / administration & dosage

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  • [Copyright] Copyright (c) 2009 American Cancer Society.
  • (PMID = 19634162.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Thiosulfates; Q20Q21Q62J / Cisplatin
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9. Nwaorgu OG, Onakoya PA: Inverted papilloma of the nose and paranasal sinuses: a fifteen-year review. Afr J Med Med Sci; 2002 Sep;31(3):191-4
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  • [Title] Inverted papilloma of the nose and paranasal sinuses: a fifteen-year review.
  • Inverted papilloma is a relatively rare epithelial neoplasm of the nose and paranasal sinuses accounting for 0.5-4% of all primary tumours of the nose.
  • This is a retrospective study of fifteen patients with histologically confirmed I.P. of the nose and paranasal sinuses seen from 1986 to 2000 at the Department of Otorhinolaryngology, University College Hospital, Ibadan.
  • Nine patients had conservative surgery (intranasal clearance/antrostomy and external fronto-ethmoidectomy) while the remaining six patients had radical surgery (lateral rhinotomy/medial maxillectomy) at various times.
  • The two patients with SCC had adjunct radiotherapy/chemotherapy in addition.
  • We therefore advocate radical surgery in our environment as the treatment of choice for effective limitation of recurrence.
  • [MeSH-major] Nose Neoplasms / epidemiology. Nose Neoplasms / pathology. Papilloma, Inverted / epidemiology. Papilloma, Inverted / pathology. Paranasal Sinus Neoplasms / epidemiology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Antineoplastic Agents / therapeutic use. Biopsy. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Chemotherapy, Adjuvant. Female. Hospitals, University. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasms, Second Primary / epidemiology. Neoplasms, Second Primary / pathology. Nigeria / epidemiology. Radiotherapy, Adjuvant. Retrospective Studies. Sex Distribution. Treatment Outcome

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  • (PMID = 12751555.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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10. Jang NY, Wu HG, Park CI, Heo DS, Kim DW, Lee SH, Rhee CS: Definitive radiotherapy with or without chemotherapy for T3-4N0 squamous cell carcinoma of the maxillary sinus and nasal cavity. Jpn J Clin Oncol; 2010 Jun;40(6):542-8
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  • [Title] Definitive radiotherapy with or without chemotherapy for T3-4N0 squamous cell carcinoma of the maxillary sinus and nasal cavity.
  • OBJECTIVE: To evaluate the efficacy and toxicity of definitive radiotherapy with or without chemotherapy for T3-4 squamous cell carcinoma of maxillary sinus and nasal cavity.
  • METHODS: Forty-two patients with T3-4N0 squamous cell carcinoma of maxillary sinus (n = 30) and nasal cavity (n = 12) received definitive radiotherapy.
  • Chemotherapy was used in 34 patients and elective neck irradiation was not used.
  • RESULTS: The 5-year overall survival/local control rates were 34%/29% for maxillary sinus cancer and 50%/52% for nasal cavity cancer.
  • For maxillary sinus cancers, a performance status of Eastern Cooperative Oncology Group >or=2 (P = 0.012), biologically equivalent dose <68 Gy (P = 0.011) and no use of chemotherapy (P = 0.037) were significant worse predictors for overall survival on log-rank analysis.
  • Biologically equivalent dose <68 Gy was independently associated with poor local control (hazard ratio, 3.32; 95% confidence interval, 1.38-7.97; P = 0.007) and overall survival (hazard ratio, 2.94; 95% confidence interval, 1.23-7.01; P = 0.015).
  • Regional recurrence occurred in only 1 of 30 patients with maxillary sinus cancer and 4 of 12 patients with nasal cavity.
  • CONCLUSIONS: The treatment outcome was poor and local control was a major problem.
  • High radiation dose, effective chemotherapy and elective neck irradiation for advanced nasal cavity cancers may improve disease control.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Maxillary Sinus Neoplasms / radiotherapy. Nasal Cavity. Nose Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Palliative Care. Prognosis. Radiation Injuries. Survival Rate

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  • (PMID = 20185459.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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11. Bradley PJ, Jones NS, Robertson I: Diagnosis and management of esthesioneuroblastoma. Curr Opin Otolaryngol Head Neck Surg; 2003 Apr;11(2):112-8
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  • [Title] Diagnosis and management of esthesioneuroblastoma.
  • Esthesioneuroblastoma is an uncommon malignant neoplasm of the nasal vault that in the past was considered benign or low-grade malignant.
  • Large tumors should be considered for preoperative chemotherapy and postoperative radiotherapy.
  • Local tumor recurrence is not uncommon and is generally related to the attention to local anatomic dissection.
  • Distant metastases may present at any time during the course of the disease, generally within 36 months, and may respond to local radiotherapy or systemic chemotherapy.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / diagnosis. Esthesioneuroblastoma, Olfactory / therapy. Nose Neoplasms / diagnosis. Nose Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Female. Humans. Male. Neoplasm Staging. Otorhinolaryngologic Surgical Procedures / methods. Prognosis. Radiotherapy / methods. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 14515089.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 58
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12. Wormald R, Sheahan P, Timon C: A case of head and neck cancer metastasizing to the axillary lymph nodes. Ear Nose Throat J; 2010 Aug;89(8):E24-6
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  • [Title] A case of head and neck cancer metastasizing to the axillary lymph nodes.
  • Metastases of head and neck cancers to the axillary lymph nodes are rare.
  • Positron-emission tomography/computed tomography demonstrated high F18-fluorodeoxyglucose uptake in the neck and also in the right axilla.
  • The patient was subsequently treated with chemoradiotherapy, but 6 months later he developed an SCC in the lung.
  • The lung lesion was also treated with chemotherapy, but the patient died 5 months later.
  • Our case is unique among similar cases in that our patient had not undergone any previous treatment of the neck primary.
  • [MeSH-major] Axilla. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / therapy. Drug Therapy. Head and Neck Neoplasms / pathology. Lymph Nodes / surgery. Neck Dissection. Radiotherapy
  • [MeSH-minor] Aged. Biopsy, Needle. Combined Modality Therapy. Fatal Outcome. Humans. Lymphatic Metastasis / pathology. Male. Positron-Emission Tomography

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  • (PMID = 20737365.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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13. Hu WH, Xie FY, Fang SH, Jiao JJ, Yan C, Peng WJ, Fu XY, Zhang F: [Cancer of the nasal cavity]. Zhonghua Zhong Liu Za Zhi; 2005 Feb;27(2):117-21
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  • [Title] [Cancer of the nasal cavity].
  • OBJECTIVE: To analyze the factors affecting prognosis of patients with nasal carcinoma.
  • The 5-year survival rate was 55.8% in squamous-cell carcinoma, 44.0% in adenocarcinoma, 59.7% in undifferentiated carcinoma, 76.3% in adenoid cystic carcinoma, 71.4% in mucoepidermoid carcinoma, 25.0% in rhabdomyosarcoma, 26.7% in malignant melanoma, 50.0% in neuroblastoma (P > 0.05).
  • The 5-year survival rate was 73.8% in patients whose cancer completely disappeared after treatment.
  • It was 41.6% in patients whose cancer incompletely disappeared, and 34.3% in patients whose cancer remained refractory (P < 0.01).
  • That with chemotherapy only was 25.0% whereas that of patients treated with combination treatment was 61.8% (P > 0.05).
  • CONCLUSION: Clinical stage, immediate therapeutic response and involvement of sphenoidal or maxillary sinus; but not the pathologic type, the presence of cervical metastasis nor the method of treatment, are the factors affecting the prognosis of patients with nasal carcinoma.
  • [MeSH-major] Nasal Cavity. Nose Neoplasms / mortality. Nose Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Multivariate Analysis. Prognosis. Survival Rate

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  • (PMID = 15946555.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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14. Sato H, Murai K, Kanda T, Mimura R, Hiratsuka Y: Association of chromium exposure with multiple primary cancers in the nasal cavity. Auris Nasus Larynx; 2003 Feb;30(1):93-6
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  • [Title] Association of chromium exposure with multiple primary cancers in the nasal cavity.
  • A 56-year-old man who had worked at a chromate factory for 13 years developed squamous cell carcinoma of the left nasal cavity 11 years after retirement.
  • He received intra-arterial chemotherapy, followed by surgery.
  • Two years later, an adenocarcinoma was identified in the same nasal cavity just above the previous surgical region.
  • Microsatellite markers were examined in the second tumor specimen as a possible factor for carcinogenesis; however, replication errors were not observed in any of four loci (D2S123, D3S1067, TP53, D18S474) tested.
  • The present case seems to have resulted from long-term exposure to chromium and, to our knowledge, is the first reported case with multiple primary cancers in the nasal cavity associated with chromium exposure.
  • [MeSH-major] Adrenal Gland Neoplasms / chemically induced. Carcinoma, Squamous Cell / chemically induced. Chromium / adverse effects. Nasal Cavity / pathology. Neoplasms, Multiple Primary / chemically induced. Nose Neoplasms / chemically induced

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  • (PMID = 12589859.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0R0008Q3JB / Chromium
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15. Chou RH, Wilder RB, Wong MS, Forster KM: Recent advances in radiotherapy for head and neck cancers. Ear Nose Throat J; 2001 Oct;80(10):704-7, 711-4, 716 passim
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  • [Title] Recent advances in radiotherapy for head and neck cancers.
  • Advancements in surgery have made it possible to resect cancers that had previously been regarded as incurable.
  • Similarly, new developments in radiation oncology have helped improve the outlook for patients with locally advanced or recurrent head and neck cancers.
  • These recent developments have allowed radiation oncologists to escalate the dose of radiation delivered to tumors while minimizing the dose delivered to surrounding normal tissue.
  • Additionally, more continues to be learned about the optimum delivery of chemotherapy.
  • This article provides an update on the status of these new developments in the treatment of head and neck cancers.
  • [MeSH-minor] Combined Modality Therapy. Dose Fractionation. Humans. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Conformal / methods. Radiotherapy, High-Energy / adverse effects. Radiotherapy, High-Energy / methods. Survival Rate

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  • (PMID = 11605568.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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16. Garandawa HI, Ahmad BM, Nggada HA: Nasopharyngeal cancer in North--Eastern Nigeria: clinical trends. Niger J Clin Pract; 2009 Dec;12(4):379-82

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  • [Title] Nasopharyngeal cancer in North--Eastern Nigeria: clinical trends.
  • BACKGROUND: Nasopharyngeal cancer is the malignancy of the posterior aspect of the nose called Nasopharynx.
  • AIM: To determine prevalence, clinical trends and histopathological types of Nasopharyngeal cancer in Maiduguri, North Eastern Nigeria.
  • PATIENTS AND METHOD: Fifteen year retrospective evaluation of patient's case notes and cancer registry records of 40 patients with histologically confirmed nasopharyngeal cancer between 1991-2005.
  • RESULTS: Nasopharyngeal cancers constituted 35.1% of all malignancies of ear, nose, throat during the study period.
  • The M:F was 2.1-1, the mean age was 39(+/- 16.5) years and a peak age group and its occurrence of 40-49 years.
  • The commonest histological type was squamous cell carcinoma(92.5%).
  • Patients who received chemotherapy in addition to radiotherapy and higher symptom free period.
  • CONCLUSION: Cancer is a difficult disease to diagnose at an stage.
  • A meticulous ear, nose and throat examination and thorough evaluation of nasal symptoms with associated cervical lymphadenopathy may lead to an early diagnosis of nasopharyngeal cancer's.

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  • (PMID = 20329676.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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17. Haddad R, Cohen M, Kaplan O, Greenberg R, Kashtan H: [Photodynamic therapy of nasal basal cell carcinoma]. Harefuah; 2001 Jan;140(1):25-7, 86
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  • [Title] [Photodynamic therapy of nasal basal cell carcinoma].
  • Photodynamic therapy (PDT) is a noninvasive modality used topically for several skin cancers.
  • We evaluated the effects of PDT on basal cell carcinoma (BCC) of the nose, using aminolevulinic acid (ALA) as a photosensitizer and a non-laser light source (Versa-Light).
  • A paste of 20% ALA was applied topically to biopsy-proven BCC of the nose.
  • Patients who did not respond after 2 treatments were referred for surgery.
  • [MeSH-major] Aminolevulinic Acid / therapeutic use. Carcinoma, Basal Cell / drug therapy. Nose Neoplasms / drug therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use
  • [MeSH-minor] Administration, Topical. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Recurrence. Treatment Outcome

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  • (PMID = 11242893.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Israel
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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18. Daele JJ, Vander Poorten V, Rombaux P, Hamoir M: Cancer of the nasal vestibule, nasal cavity and paranasal sinuses. B-ENT; 2005;Suppl 1:87-94; quiz 95-6
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  • [Title] Cancer of the nasal vestibule, nasal cavity and paranasal sinuses.
  • The usual clinical presentation of sinonasal tumours includes symptoms that are indistinguishable from inflammatory sinus disease, namely nasal airway obstruction, pain, and epistaxis.
  • Computed tomography is the most reliable and informative imaging tool for evaluating the cancers of the paranasal sinuses.
  • Magnetic resonance imaging is essential for tumour mapping because of the excellent tissue characterisation and the possibility of differentiating between neoplasms and retained secretions.
  • The response of sinonasal tract tumours to radiation therapy varies with the stage and histology of the tumour.
  • Management of these tumours requires a multimodal approach, involving surgery, radiation therapy and, increasingly in recent years, chemotherapy.
  • [MeSH-major] Nasal Cavity / pathology. Nose Neoplasms / diagnosis. Paranasal Sinus Neoplasms / diagnosis
  • [MeSH-minor] Chemotherapy, Adjuvant. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 16363270.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 49
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19. Hanna E, DeMonte F, Ibrahim S, Roberts D, Levine N, Kupferman M: Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results. Arch Otolaryngol Head Neck Surg; 2009 Dec;135(12):1219-24
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  • [Title] Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results.
  • OBJECTIVE: To evaluate the oncologic outcomes of patients with sinonasal cancer treated with endoscopic resection.
  • SETTING: Tertiary care academic cancer center.
  • PATIENTS: All patients with biopsy-proved malignant neoplasm of the sinonasal region who were treated with endoscopic resection between 1992 and 2007 were included in the study, and their charts were reviewed for demographics, histopathologic findings, treatment details, and outcome.
  • Of the 120 patients, 41% presented with previously untreated disease, 46% presented with persistent disease that had been partially resected, and 13% presented with recurrent disease after prior treatment.
  • The most common site of tumor origin was the nasal cavity (52%), followed by the ethmoid sinuses (28%).
  • However, the T-stage distribution was significantly different between the EEA group and the CEA group.
  • The most common tumor types were esthesioneuroblastoma (17%), sarcoma (15%), adenocarcinoma (14%), melanoma (14%), and squamous cell carcinoma (13%).
  • Of the 120 patients, 50% were treated with surgery alone, 37% received postoperative radiation therapy, and 13% were treated with surgery, radiation therapy, and chemotherapy.
  • CONCLUSIONS: To the best of our knowledge, this is the largest US series to date of patients with malignant tumors of the sinonasal tract treated with endoscopic resection.
  • Our results suggest that, in well-selected patients and with appropriate use of adjuvant therapy, endoscopic resection of sinonasal cancer results in acceptable oncologic outcomes.
  • [MeSH-minor] Adenocarcinoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / surgery. Chemotherapy, Adjuvant. Child. Craniotomy. Disease-Free Survival. Esthesioneuroblastoma, Olfactory / surgery. Ethmoid Sinus. Female. Humans. Male. Melanoma / surgery. Middle Aged. Neoplasm Recurrence, Local. Nose Neoplasms / mortality. Nose Neoplasms / surgery. Radiotherapy, Adjuvant. Retrospective Studies. Sarcoma / surgery

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  • (PMID = 20026819.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Biel MA: Photodynamic therapy treatment of early oral and laryngeal cancers. Photochem Photobiol; 2007 Sep-Oct;83(5):1063-8
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  • [Title] Photodynamic therapy treatment of early oral and laryngeal cancers.
  • Photodynamic therapy (PDT) is a nonsurgical, minimally invasive treatment that uses a light source to activate light-sensitive drugs or photosensitizers in the treatment of cancer and other diseases.
  • PDT has been successfully employed to treat early carcinomas of the oral cavity and larynx preserving normal tissue and vital functions of speech and swallowing.
  • Cure rates with a single treatment for early laryngeal and oral cancers were 91% and 94%, respectively.
  • PDT is an effective primary and alternative treatment modality for early oral cavity and laryngeal cancers.
  • [MeSH-major] Dihematoporphyrin Ether / therapeutic use. Laryngeal Neoplasms / drug therapy. Mouth Neoplasms / drug therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use

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  • (PMID = 17880501.001).
  • [ISSN] 0031-8655
  • [Journal-full-title] Photochemistry and photobiology
  • [ISO-abbreviation] Photochem. Photobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 97067-70-4 / Dihematoporphyrin Ether
  • [Number-of-references] 33
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21. Amusa YB, Adediran IA, Akinpelu VO, Famurewa OC, Olateju SO, Adegbehingbe BO, Komolafe EO, Faponle AF, Olasode BJ: Burkitt's lymphoma of the head and neck region in a Nigerian tertiary hospital. West Afr J Med; 2005 Apr-Jun;24(2):139-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Burkitt's lymphoma is endemic in Nigeria; it forms about 39% of all childhood cancers.
  • In recent times more of these cases are being seen presenting first to the Ear Nose and Throat clinic.
  • OBJECTIVE: This study is designed to look at the pattern of presentation of head and Neck Burkitt's lymphoma at a Nigerian Tertiary hospital and to evaluate current treatment modality.
  • The proportion of the tumor affecting the Head and neck region were noted.
  • The most common sites that were affected are; the jaw (65.9%), nasal and paranasal sinuses (12.2).
  • Combination Chemotherapy comprising Cyclophosphamide, Oncovin, Methotrexate and Prednisolone (COMP) was the mainstay of management.
  • The treatment outcome was only favorable in 36.6%.
  • Frank drug resistance was found in (2.6%).
  • Some complications of treatment were noted.
  • [MeSH-major] Burkitt Lymphoma / diagnosis. Head and Neck Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Surveys and Questionnaires. Time Factors. Treatment Outcome

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  • [ErratumIn] West Afr J Med. 2005 Jul-Sep;24(3):189. Adegbeingbe, OD [corrected to Adegbehingbe, BO]
  • (PMID = 16092315.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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22. Corti MA, Mainetti C: Methylaminolevulinic acid-based photodynamic therapy: the patient's view. Photomed Laser Surg; 2010 Oct;28(5):697-702
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Methylaminolevulinic acid-based photodynamic therapy: the patient's view.
  • Topical photodynamic therapy (PDT) with methylaminolevulinate (MAL) for nonmelanomatous skin cancers (NMSC) has proven efficient and safe.
  • Scarring was observed more often on the nose (21%, 3 of 14 lesions).
  • Risk factors for a greater severity of pain were lesions on the scalp (average pain score: 6.62) and on the forehead (average: 7.00) and treatment over an extended area (average: 7.32).
  • Treatment on the nose (average: 3.29) or on the thorax (average: 3.00) was less painful.
  • [MeSH-major] Aminolevulinic Acid / therapeutic use. Pain Measurement / drug effects. Photochemotherapy / methods. Precancerous Conditions / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Chi-Square Distribution. Female. Follow-Up Studies. Humans. Male. Middle Aged. Patient Satisfaction. Photosensitizing Agents / therapeutic use. Prospective Studies. Risk Assessment. Statistics, Nonparametric. Treatment Outcome

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  • (PMID = 20961234.001).
  • [ISSN] 1557-8550
  • [Journal-full-title] Photomedicine and laser surgery
  • [ISO-abbreviation] Photomed Laser Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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23. Oral pilocarpine: new preparation. Xerostomia after radiation therapy: moderately effective but costly. Prescrire Int; 2002 Aug;11(60):99-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral pilocarpine: new preparation. Xerostomia after radiation therapy: moderately effective but costly.
  • (1) Dry mouth (xerostomia) is a frequent complication of radiation therapy for cancers of the ear nose and throat.
  • Local measures such as saliva substitutes and anetholtrithione are either moderately effective, inadequately evaluated or little better than placebo. (2) Marketing authorization has been granted in France for an oral formulation of pilocarpine, an old parasympathomimetic agent, in the treatment of radiotherapy-induced xerostomia. (3) According to the results of two double-blind trials, pilocarpine (15-30 mg/day) improves symptoms in about 50 % of patients, compared to improvement in 25% of patients taking placebo.
  • The drug is slow to take effect and has little impact on daily life.
  • Pilocarpine must therefore be used with caution in patients with asthma, cardiac arrhythmia, iridocyclitis, and closed-angle glaucoma. (5) In France, this pilocarpine formulation costs 18 times more than a preparation of pilocarpine 2% eye drops used orally (off licence). (6) In practice, patients needing symptomatic treatment of xerostomia after radiotherapy may benefit from oral pilocarpine but, given its limited efficacy and its adverse effects, other local treatments should be tried first.
  • [MeSH-major] Pilocarpine / therapeutic use. Xerostomia / drug therapy
  • [MeSH-minor] Administration, Oral. Drug Costs. France. Humans. Muscarinic Agonists / administration & dosage. Muscarinic Agonists / adverse effects. Muscarinic Agonists / economics. Muscarinic Agonists / therapeutic use. Radiotherapy / adverse effects. Randomized Controlled Trials as Topic. Treatment Outcome

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  • (PMID = 12199276.001).
  • [ISSN] 1167-7422
  • [Journal-full-title] Prescrire international
  • [ISO-abbreviation] Prescrire Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Muscarinic Agonists; 01MI4Q9DI3 / Pilocarpine
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24. Dulguerov P, Allal AS: Nasal and paranasal sinus carcinoma: how can we continue to make progress? Curr Opin Otolaryngol Head Neck Surg; 2006 Apr;14(2):67-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nasal and paranasal sinus carcinoma: how can we continue to make progress?
  • PURPOSE OF REVIEW: New developments in the nasal and paranasal sinus cancers are reviewed.
  • RECENT FINDINGS: In addition to woodworking, several risk factors for nasal and paranasal sinus cancers have been identified, most notably smoking.
  • Progress in the differential diagnosis of small round cell nasal and paranasal sinus cancers allows the precise diagnosis of esthesioneuroblastoma.
  • Despite recent improvements, T staging for ethmoid and nasal cavity needs refinement.
  • An association of surgery and radiation therapy remains the best treatment modality.
  • Major developments include endoscopic resection of nasal and paranasal sinus cancers, high-precision radiotherapy techniques such as intensity-modulated radiotherapy, and proton-beam radiotherapy.
  • There is probably no role for chemotherapy in esthesioneuroblastoma.
  • Although chemotherapy is important for aggressive neoplasms, its generalized use for nasal and paranasal sinus cancers awaits the application/development of newer drugs.
  • These drugs might be applied locally since the majority of recurrences remain local.
  • SUMMARY: Progress in the treatment of nasal and paranasal sinus cancers could be achieved through better prevention and the developments of more selective treatments such as endoscopic resection, high-precision radiotherapy, and new chemotherapy drugs.
  • [MeSH-major] Carcinoma. Nasal Cavity / pathology. Nose Neoplasms. Paranasal Sinus Neoplasms
  • [MeSH-minor] Combined Modality Therapy. Humans. Lymphatic Metastasis. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Survival Analysis

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  • (PMID = 16552261.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 61
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25. Biel M: Advances in photodynamic therapy for the treatment of head and neck cancers. Lasers Surg Med; 2006 Jun;38(5):349-55
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  • [Title] Advances in photodynamic therapy for the treatment of head and neck cancers.
  • Photodynamic therapy (PDT) is an FDA-approved minimally invasive medical treatment modality that utilizes light in the presence of oxygen to activate photosensitizing agents that are relatively selectively concentrated in abnormal or neoplastic cells resulting in cell death.
  • At the present time, PDT has been approved for clinical treatment in the United States, European Union, Canada, Russia, and Japan.
  • In the United States, US Food and Drug administration approval has been given for the use of PDT in the treatment of Barrett's esophagus, obstructing esophageal carcinoma and early and obstructing tracheobronchial carcinoma using the photosensitizer Photofrin; actinic keratosis using the photosensitizer Levulan (aminolevulinic acid); and macular degeneration using the photosensitizer BPD.
  • In the EU the above noted indications have also been approved in addition to the treatment of early head and neck cancers and palliative treatment of head and neck cancer using the photosensitizer Foscan; and treatment of basal and squamous cell skin cancers using the photosensitizer Metvix.
  • [MeSH-major] Dihematoporphyrin Ether / therapeutic use. Head and Neck Neoplasms / therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ambulatory Care. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Humans. Male. Melanoma / therapy. Middle Aged. Minnesota / epidemiology. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / therapy. Papilloma / therapy. Retrospective Studies. Sarcoma, Kaposi / therapy

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16788923.001).
  • [ISSN] 0196-8092
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 97067-70-4 / Dihematoporphyrin Ether
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26. Llorente JL, Pérez-Escuredo J, Alvarez-Marcos C, Suárez C, Hermsen M: Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review. Eur Arch Otorhinolaryngol; 2009 Jan;266(1):1-7
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  • [Title] Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review.
  • Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare epithelial cancer of the nasal cavities and paranasal sinuses.
  • Standard therapeutic modalities include surgery followed by radiotherapy in advanced stages, sometimes with chemotherapy treatment.
  • The molecular genetic mechanisms underlying the development and progression of this tumor is not understood.
  • This review aims to describe the clinico-pathological characteristics of this relatively unknown tumor and to summarize the knowledge on genetic and chromosomal analyses up to the present time.
  • [MeSH-major] Adenocarcinoma / etiology. Neoplasm Recurrence, Local / pathology. Occupational Exposure / adverse effects. Paranasal Sinus Neoplasms / etiology. Wood / adverse effects
  • [MeSH-minor] Dust. Female. Genetic Predisposition to Disease / epidemiology. Humans. Immunohistochemistry. Male. Molecular Biology. Neoplasm Staging. Prognosis. Survival Analysis. Tomography, X-Ray Computed

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  • (PMID = 18560862.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Dust
  • [Number-of-references] 47
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27. Knight V, Kleinerman ES, Waldrep JC, Giovanella BC, Gilbert BE, Koshkina NV: 9-Nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice. Ann N Y Acad Sci; 2000;922:151-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 9-Nitrocamptothecin liposome aerosol treatment of human cancer subcutaneous xenografts and pulmonary cancer metastases in mice.
  • The purpose of this study was to test the anticancer properties of the water-insoluble derivative of camptothecin, 9-nitrocamptothecin (9NC), administered in a liposome formulation (L-9NC) in aerosol to mice with subcutaneous xenografts of three human cancers and in mice with murine melanoma and human osteosarcoma pulmonary metastases.
  • The drug was formulated with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 microns mass median aerodynamic diameter and a geometric standard deviation of 2.0.
  • The aerosol was generated with the nebulizer flowing at 10 l/min and delivered to mice in sealed plastic cages or in a nose-only exposure chamber.
  • With subcutaneous tumors, growth was greatly inhibited or tumors were undetectable after several weeks of treatment.
  • We also showed that oral dosage with L-9NC had no detectable effect on cancer growth, and thus the benefit from aerosol treatment was due to pulmonary deposition and not the larger fraction of drug deposited in the nose of mice during aerosol treatment which is promptly swallowed.
  • Intramuscular L-9NC in slightly larger doses than given in the aerosol had detectable anticancer activity, but it was significantly less than in mice receiving the drug by aerosol.
  • With metastatic pulmonary cancers, treated animals showed highly significantly less cancer growth than control animals.
  • L-9NC aerosol showed a major therapeutic benefit in the treatment of subcutaneous human cancer xenografts in nude mice, suggesting that cancers at systemic sites might be responsive to this treatment.
  • In addition, the strong anticancer effect of L-9NC aerosol on pulmonary metastases offers a therapeutic approach for treatment of pulmonary cancers.
  • Thus, L-9NC aerosol may have applicability in the treatment of cancers throughout the body.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Camptothecin / administration & dosage. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary
  • [MeSH-minor] Aerosols. Animals. Bone Neoplasms / drug therapy. Bone Neoplasms / pathology. Colonic Neoplasms / drug therapy. Drug Carriers. Female. Humans. Liposomes. Mammary Neoplasms, Experimental / drug therapy. Melanoma, Experimental / drug therapy. Melanoma, Experimental / secondary. Mice. Mice, Inbred C57BL. Mice, Nude. Microscopy, Electron. Osteosarcoma / drug therapy. Osteosarcoma / secondary. Particle Size. Phosphatidylcholines / administration & dosage. Phosphatidylcholines / chemistry. Xenograft Model Antitumor Assays

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  • (PMID = 11193890.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 42992; United States / NCI NIH HHS / CA / CA-16672
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aerosols; 0 / Antineoplastic Agents; 0 / Drug Carriers; 0 / Liposomes; 0 / Phosphatidylcholines; 18285-71-7 / 1,2-dilauroylphosphatidylcholine; H19C446XXB / rubitecan; XT3Z54Z28A / Camptothecin
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28. Karaman E, Duman C, Mercan H, Ozaras R, Cansız H: Relapsing deep neck infection may indicate a coexisting esophagus cancer. Kulak Burun Bogaz Ihtis Derg; 2009 Mar-Apr;19(2):103-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relapsing deep neck infection may indicate a coexisting esophagus cancer.
  • Primary head and neck cancers may present initially with neck abscesses or deep neck infections.
  • This presentation leads to delay of the diagnosis of underlying cancer.
  • Head and neck cancers which present with deep neck infection initially have rarely been described.
  • [MeSH-major] Abscess / etiology. Carcinoma, Squamous Cell / diagnosis. Esophageal Neoplasms / diagnosis. Infection / diagnosis
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Cephalosporins / therapeutic use. Cervical Vertebrae / radiography. Female. Humans. Klebsiella Infections / diagnosis. Klebsiella Infections / drug therapy. Middle Aged. Necrosis. Recurrence. Tomography, X-Ray Computed

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  • (PMID = 19796009.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Cephalosporins
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29. Baptista P, Garcia Velloso MJ, Salvinelli F, Casale M: Radioguided surgical strategy in mucosal melanoma of the nasal cavity. Clin Nucl Med; 2008 Jan;33(1):14-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radioguided surgical strategy in mucosal melanoma of the nasal cavity.
  • Sinonasal mucosal melanoma (MM), although very rare (<1% of the all MM), is second only to squamous cell carcinoma among cancers of the nasal region and still represents a challenging problem in head and neck cancer.
  • A 60-year-old woman had nasal MM stage I, which was treated with concomitant probe-guided tumor excision and an elective neck dissection after sentinel lymph node biopsy.
  • The radioactivity status of the tumor and lymph nodes were compared with the histopathologic specimen.
  • Surgical margins, sentinel lymph node, and lymphadenectomy were free of tumor.
  • The patient was seen in frequent and regular follow-up and was free of disease without any other treatment (radiotherapy, immunotherapy, or chemotherapy).
  • A multidisciplinary approach and further studies with a longer follow-up are needed to substantiate the accuracy and safety of this strategy in the treatment of an aggressive neoplasm like MM of the head and neck, which still has a very poor prognosis.
  • [MeSH-major] Melanoma / surgery. Nose Neoplasms / surgery
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Female. Gamma Cameras. Humans. Middle Aged. Radiosurgery. Sentinel Lymph Node Biopsy. Technetium Tc 99m Aggregated Albumin. Tomography, X-Ray Computed

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  • (PMID = 18097249.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Technetium Tc 99m Aggregated Albumin; 0 / technetium Tc 99m nanocolloid
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30. Price DL, Wong RJ, Randolph GW: Invasive thyroid cancer: management of the trachea and esophagus. Otolaryngol Clin North Am; 2008 Dec;41(6):1155-68, ix-x
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive thyroid cancer: management of the trachea and esophagus.
  • Well-differentiated thyroid cancer most commonly presents as an intrathyroidal tumor; however, extrathyroidal extension occurs in approximately 6% to 13% of patients and carries a significant negative impact on survival.
  • Adjuvant postoperative therapies for thyroid cancers with extrathyroidal extension include thyroid hormone suppression, radioactive iodine therapy, and external beam radiotherapy.
  • This summary reviews approaches to the management of invasive thyroid cancers involving the aerodigestive tract.

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  • (PMID = 19040976.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA009685-17; United States / NCI NIH HHS / CA / T32 CA009685; United States / NCI NIH HHS / CA / T32 CA009685-17
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 64
  • [Other-IDs] NLM/ NIHMS111817; NLM/ PMC2750808
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31. Martinez Del Pero M, Chaudhry A, Jones RB, Sivasothy P, Jani P, Jayne D: B-cell depletion with rituximab for refractory head and neck Wegener's granulomatosis: a cohort study. Clin Otolaryngol; 2009 Aug;34(4):328-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: This study aimed to evaluate the response of refractory Wegener's granulomatosis affecting the ear, nose and throat and granulomatous eye disease to B-cell depletion with rituximab.
  • MAIN OUTCOME MEASURES: Demographic and follow-up data at five time points were recorded.
  • Total Birmingham Vasculitis Assessment score decreased after rituximab at all time points (P < 0.001).
  • Four of five patients with retro-orbital involvement responded well to treatment.
  • Two patients were considered secondary failures requiring alternative therapy after an initial response.
  • Adverse events included four major chest infections, two cancers and six infusion reactions.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. B-Lymphocytes / drug effects. Granulomatosis with Polyangiitis / drug therapy. Immunologic Factors / therapeutic use. Lymphocyte Depletion / methods. Otorhinolaryngologic Diseases / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Antibodies, Antineutrophil Cytoplasmic / blood. Antibodies, Monoclonal, Murine-Derived. Cohort Studies. Cyclophosphamide / adverse effects. Cyclophosphamide / therapeutic use. Dose-Response Relationship, Drug. Drug Administration Schedule. Drug Therapy, Combination. Female. Follow-Up Studies. Humans. Immunosuppressive Agents / adverse effects. Immunosuppressive Agents / therapeutic use. Magnetic Resonance Imaging. Male. Middle Aged. Prednisolone / adverse effects. Prednisolone / therapeutic use. Recurrence. Retreatment. Rituximab. Young Adult

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  • [CommentIn] Clin Otolaryngol. 2009 Dec;34(6):581-2 [20070778.001]
  • (PMID = 19673980.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunologic Factors; 0 / Immunosuppressive Agents; 4F4X42SYQ6 / Rituximab; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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32. Gladkova ND, Maslennikova AV, Balalaeva IV, Vysel'tseva IuV, Terent'eva AB, Il'in NV, Lazareva VA: [Potential of optical coherence tomography for diagnosing mucositis in cancer of the nasal cavity and throat in the course of radio- and chemoradiotherapy]. Vopr Onkol; 2006;52(4):443-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Potential of optical coherence tomography for diagnosing mucositis in cancer of the nasal cavity and throat in the course of radio- and chemoradiotherapy].
  • The monitoring data on mucosa of the nasal cavity and throat using optical coherence tomography imaging in 14 cases during radiochemotherapy are presented.
  • Typical alterations such as reduction in contrast distinctions between tissue layers to an extent that it blurs down completely at the peak of radiation-related response are discussed.
  • [MeSH-major] Mucositis / diagnosis. Mucositis / etiology. Oropharyngeal Neoplasms / drug therapy. Oropharyngeal Neoplasms / radiotherapy. Tomography, Optical Coherence
  • [MeSH-minor] Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Female. Humans. Male. Middle Aged. Mouth Mucosa / drug effects. Mouth Mucosa / radiation effects. Radiotherapy, Adjuvant

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  • (PMID = 17024819.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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