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1. Inenaga C, Morii K, Tamura T, Tanaka R, Takahashi H: Mesenchymal chondrosarcoma of the sellar region. Acta Neurochir (Wien); 2003 Jul;145(7):593-7; discussion 597
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  • However, no such malignant tumour has been described in the sellar region.
  • Upon initial admission, no endocrinological abnormalities were found, and computed tomography and magnetic resonance imaging revealed a mass with calcification in the sella and right cavernous sinus.
  • INTERVENTION: For this malignant tumour, three surgical resections, two sessions of gamma-knife radiosurgery, one session of fractional irradiation, and one cycle of chemotherapy were performed, resulting in only brief arrest of the tumour growth.
  • Pathologically, the tumour consisted of undifferentiated small cells of high cellularity, and islands of hyaline cartilage.
  • CONCLUSION: Although malignant tumours in the sellar region are rare, they should be considered in the differential diagnosis of various sellar tumours typified by non-functioning pituitary adenoma, and mesenchymal chondrosarcoma is one possible candidate.

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  • (PMID = 12910404.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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2. Yaman E, Benekli M, Coskun U, Sezer K, Ozturk B, Kaya AO, Yildiz R, Uluoglu O, Buyukberber S: Intrasellar plasmacytoma: an unusual presentation of multiple myeloma. Acta Neurochir (Wien); 2008 Sep;150(9):921-4; discussion 924
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  • Occasionally, they can be misdiagnosed as a nonfunctioning adenoma because of radiological and clinical similarities.
  • Initial diagnosis of a nonfunctioning pituitary adenoma was later overruled by a repeat biopsy, which showed a plasmacytoma.
  • The tumor stained positively for CD138 and kappa light chain.
  • Further studies confirmed the diagnosis of multiple myeloma.
  • The patient was successfully treated with radiotherapy followed by systemic chemotherapy.
  • Because they have different therapeutic implications, extramedullary plasmacytomas involving pituitary gland should be considered in the differential diagnosis of a nonfunctioning pituitary mass.
  • [MeSH-major] Multiple Myeloma / complications. Multiple Myeloma / diagnosis. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / etiology. Plasmacytoma / diagnosis. Plasmacytoma / etiology
  • [MeSH-minor] Adenoma / diagnosis. Aged. Biopsy. Diagnosis, Differential. Female. Humans. Immunoglobulin kappa-Chains / metabolism. Magnetic Resonance Imaging. Sella Turcica. Syndecan-1 / metabolism

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  • (PMID = 18726062.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Immunoglobulin kappa-Chains; 0 / Syndecan-1
  • [Number-of-references] 24
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3. Gur C, Lalazar G, Salmon A, Dubiner V, Gross DJ: Metastatic pancreatic neuroendocrine tumor presenting as a pituitary space occupying lesion: a case report. Pituitary; 2008;11(3):293-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic pancreatic neuroendocrine tumor presenting as a pituitary space occupying lesion: a case report.
  • Neuroendocrine tumor metastases to the pituitary gland are very rare.
  • There are few case reports of carcinoid tumor metastases to the pituitary, but no cases of pancreatic neuroendocrine pituitary metastases have been reported.
  • In this report we present a 55-year-old female with a sellar mass, ophthalmoplegia and headaches initially thought to represent an invasive null cell pituitary adenoma.
  • However a histological (trans-sphenoidal and liver biopsies) and systemic investigation proved it to be a metastasis of an undiagnosed pancreatic neuroendocrine tumor.
  • Our patient was unique in respect to the location of the metastasis and the uncharacteristically high proliferative index of her tumor.
  • She received conventional therapy consisting of Sandostatin, chemotherapy and radiotherapy as well as labeled somatostatin following an avid uptake on octreotide scanning.
  • [MeSH-major] Neuroendocrine Tumors / secondary. Pancreatic Neoplasms / pathology. Pituitary Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Fatal Outcome. Female. Humans. Middle Aged. Radiotherapy, Adjuvant. Tomography, Emission-Computed, Single-Photon


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4. Zhang W, Murao K, Imachi H, Iwama H, Chen K, Fei Z, Zhang X, Ishida T, Tamiya T: Suppression of prolactin expression by cabergoline requires prolactin regulatory element-binding protein (PREB) in GH3 cells. Horm Metab Res; 2010 Jul;42(8):557-61
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  • The prolactin regulatory element-binding protein (PREB) is a transcriptional factor that regulates prolactin (PRL) promoter activity in the anterior pituitary.
  • Prolactinomas are the most common pituitary tumors.
  • Administration of cabergoline, a selective dopamine D2-receptor agonist, has become the initial therapy of choice for most patients with prolactinomas.
  • Samples of ten prolactinomas and ten nonfunctioning pituitary adenomas were analyzed by immunohistochemistry to detect the expression of PREB.
  • The effect of cabergoline on PREB expression was assessed by western blotting and real-time polymerase chain reaction (PCR) analysis.
  • Immunohistochemical analysis revealed strong positive PREB expression in the prolactinoma tissue, but extremely weak or undetected expression in the nonfunctioning pituitary tumor tissue.
  • Western blots probed with a PREB-specific antiserum revealed that the relative abundance of the PREB protein in the GH3 cells decreased in a dose-dependent manner in response to cabergoline treatment, as did the relative abundance of PREB mRNA.
  • [MeSH-major] DNA-Binding Proteins / metabolism. Down-Regulation / drug effects. Ergolines / pharmacology. Guanine Nucleotide Exchange Factors / metabolism. Prolactin / genetics. Transcription Factors / metabolism
  • [MeSH-minor] Cell Line, Tumor. Humans. Prolactinoma / metabolism. Prolactinoma / pathology. Promoter Regions, Genetic / genetics. Transcription, Genetic / drug effects

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20411477.001).
  • [ISSN] 1439-4286
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Ergolines; 0 / Guanine Nucleotide Exchange Factors; 0 / PREB protein, human; 0 / Transcription Factors; 9002-62-4 / Prolactin; LL60K9J05T / cabergoline
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5. Talvinen K, Tuikkala J, Grönroos J, Huhtinen H, Kronqvist P, Aittokallio T, Nevalainen O, Hiekkanen H, Nevalainen T, Sundström J: Biochemical and clinical approaches in evaluating the prognosis of colon cancer. Anticancer Res; 2006 Nov-Dec;26(6C):4745-51
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  • BACKGROUND: Colorectal adenocarcinoma is a common malignant neoplasm in the Western world.
  • To achieve optimal treatment results, the risk estimation of recurrence should be as accurate as possible.
  • MATERIALS AND METHODS: Tissue material from tumour and normal mucosa was taken from six patients and was analysed to screen aberrantly expressed genes using cDNA microarray.
  • For this purpose a tissue array material of 114 colorectal cancer patients was obtained.
  • RESULTS: Processes such as cellular defense, cell structure, motility and cell division were found to be notably represented among the most deregulated genes.
  • A significant portion of the overexpressed genes included those functioning in the cell cycle.
  • CONCLUSION: Tumour stage is superior in estimating the prognosis of patients with colonic cancer compared with the grading of cell cycle regulators or histological grade of the cancer.
  • The study of regional lymph nodes is essential to identify the patients who would benefit from adjuvant chemotherapy.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Cycle Proteins / biosynthesis. Cell Cycle Proteins / genetics. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Proteins / biosynthesis. Neoplasm Proteins / genetics. Neoplasm Staging. Oligonucleotide Array Sequence Analysis. Prognosis. Securin. Up-Regulation. cdc25 Phosphatases / biosynthesis. cdc25 Phosphatases / genetics

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  • (PMID = 17214335.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Neoplasm Proteins; 0 / Securin; 0 / pituitary tumor-transforming protein 1, human; EC 3.1.3.16 / CDC25B protein, human; EC 3.1.3.48 / cdc25 Phosphatases
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6. Svensson J, Finer N, Bouloux P, Bevan J, Jonsson B, Mattsson AF, Lundberg M, Harris PE, Koltowska-Häggström M, Monson JP, KIMS International Board: Growth hormone (GH) replacement therapy in GH deficient adults: predictors of one-year metabolic and clinical response. Growth Horm IGF Res; 2007 Feb;17(1):67-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Growth hormone (GH) replacement therapy in GH deficient adults: predictors of one-year metabolic and clinical response.
  • OBJECTIVE: This study investigated whether baseline status could predict the responsiveness to one-year growth hormone (GH) replacement therapy in adult GH deficient (GHD) patients.
  • DESIGN: A total of 380 European patients with adult onset GHD due to non-functioning pituitary adenoma that had been enrolled in Pfizer International Metabolic Database (KIMS), and that had completed one year of GH replacement therapy within KIMS, were studied.
  • Quality of life (QoL)-Assessment of GHD in Adults (QoL-AGHDA), waist circumference, waist:hip ratio, and serum lipid pattern improved.
  • Women received a higher dose of GH than men after one year, and demonstrated similar treatment response.
  • In multiple stepwise forward regression analyses, the one-year changes in QoL-AGHDA score, waist:hip ratio, and serum low density lipoprotein-cholesterol (LDL-C) level correlated inversely with the baseline values of the same variable.
  • In addition, the change after one year in QoL-AGHDA score correlated inversely with duration of hypopituitarism and baseline serum high density lipoprotein-cholesterol (HDL-C) level, and the change in waist:hip ratio correlated inversely, although more weakly, with baseline serum HDL-C level and UK citizenship and positively with baseline waist circumference and the initial GH dose.
  • Therefore, when the decision to start GH replacement is undertaken, as many outcome variables as possible should be evaluated in order to adequately evaluate the likelihood of clinical benefit.
  • Finally, women have a similar response to GH replacement as men when individualised GH dosing schedules are employed and should therefore be selected for GH therapy to a similar extent.
  • [MeSH-major] Dwarfism, Pituitary / diagnosis. Dwarfism, Pituitary / drug therapy. Growth Hormone / therapeutic use. Hormone Replacement Therapy
  • [MeSH-minor] Cohort Studies. Dose-Response Relationship, Drug. Female. Follow-Up Studies. Humans. Male. Middle Aged. Models, Statistical. Prognosis. Quality of Life. Sex Characteristics. Treatment Outcome

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  • (PMID = 17223598.001).
  • [ISSN] 1096-6374
  • [Journal-full-title] Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • [ISO-abbreviation] Growth Horm. IGF Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 9002-72-6 / Growth Hormone
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7. Cerovac V, Monteserin-Garcia J, Rubinfeld H, Buchfelder M, Losa M, Florio T, Paez-Pereda M, Stalla GK, Theodoropoulou M: The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells. Cancer Res; 2010 Jan 15;70(2):666-74
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  • [Title] The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells.
  • Rapamycin and its analogues have significant antiproliferative action against a variety of tumors.
  • Here, we investigated this model using the somatostatin analogue octreotide as a tool to decrease levels of activated Ser(473)-phosphorylated Akt (pAkt-Ser(473)) in pituitary tumor cells that express somatostatin receptors.
  • Octreotide potentiated the antiproliferative effects of rapamycin in immortalized pituitary tumor cells or human nonfunctioning pituitary adenoma cells in primary cell culture, sensitizing tumor cells even to low rapamycin concentrations.
  • Combined treatment of octreotide and rapamycin triggered G(1) cell cycle arrest, decreasing E2F transcriptional activity and cyclin E levels by increasing levels of p27/Kip1.
  • These findings show that adjuvant treatment with a somatostatin analogue can sensitize pituitary tumor cells to the antiproliferative effects of rapamycin.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / pharmacology. Octreotide / pharmacology. Pituitary Neoplasms / drug therapy. Sirolimus / pharmacology
  • [MeSH-minor] Adenoma / drug therapy. Adenoma / metabolism. Adenoma / pathology. Cell Cycle / drug effects. Cell Growth Processes / drug effects. Cell Line, Tumor. Cyclin-Dependent Kinase Inhibitor p27 / biosynthesis. Drug Synergism. Humans. Insulin Receptor Substrate Proteins / metabolism. Oncogene Protein v-akt / metabolism. Phosphorylation / drug effects. Up-Regulation


8. Lin SH, Hung YH, Lin YF: Severe hyponatremia as the presenting feature of clinically non-functional pituitary adenoma with hypopituitarism. Clin Nephrol; 2002 Jan;57(1):85-8
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  • [Title] Severe hyponatremia as the presenting feature of clinically non-functional pituitary adenoma with hypopituitarism.
  • We present two cases in which severe hyponatremia developed with weakness, light-headedness and seizure.
  • Computerized tomography of the brain revealed an adenoma of the pituitary gland.
  • These two cases illustrate that severe hyponatremia may be the presenting feature of clinically non-functional pituitary adenoma with hypopituitarism, which should be kept in mind in the differential diagnosis of hyponatremia mimicking SIADH.
  • [MeSH-major] Adenoma / complications. Hyponatremia / etiology. Pituitary Neoplasms / complications
  • [MeSH-minor] Aged. Anti-Inflammatory Agents / therapeutic use. Diagnosis, Differential. Drug Therapy, Combination. Humans. Male. Middle Aged. Prednisolone / administration & dosage. Thyroid Hormones / therapeutic use. Thyroxine / administration & dosage. Vasopressins / blood. Vasopressins / deficiency

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  • (PMID = 11837807.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Thyroid Hormones; 11000-17-2 / Vasopressins; 9PHQ9Y1OLM / Prednisolone; Q51BO43MG4 / Thyroxine
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9. Hagen C, Schroeder HD, Hansen S, Hagen C, Andersen M: Temozolomide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy. Eur J Endocrinol; 2009 Oct;161(4):631-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temozolomide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy.
  • OBJECTIVE: Aggressive pituitary tumours may be difficult to treat.
  • In a small number of cases, TMZ therapy has been reported to reduce pituitary tumour size and hormone hypersecretion.
  • DESIGN: We present three patients with pituitary tumours treated with TMZ.
  • One tumour was initially a macroprolactinoma that developed into a mixed GH- and prolactin-secreting carcinoma (patient A).
  • Two adenomas, a macroprolactinoma (patient B) and a clinically non-functioning pituitary adenoma (patient C), were highly invasive.
  • The three patients suffered from extensive tumour mass effects, and all tumours were resistant to conventional treatment.
  • RESULT: During TMZ therapy, tumour sizes were significantly reduced, hormone levels normalized and symptoms of mass effects decreased in all three cases.
  • Three years after the terminating treatment, the tumour has not regrown and hormone levels are normalized.
  • CONCLUSION: TMZ therapy significantly decreased tumour volume, hormone hypersecretion and symptoms in all three patients, corresponding to the pathological findings regarding MGMT.
  • TMZ therapy may be a new option for the treatment of resistant pituitary adenomas.


10. Deniz K, Tanriverdi F, Selçuklu A, Kontaş O, Keleştimur F: Signet ring-like cells in pituitary adenoma. Pathol Res Pract; 2008;204(3):209-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Signet ring-like cells in pituitary adenoma.
  • We describe a case of non-functioning pituitary adenoma in a 35-year-old woman with a prior history of fertility problems.
  • Histological examination of the tumor revealed signet ring-like cell areas admixed with minor conventional round-polygonal neoplastic cells.
  • The two populations of tumor cells showed strong immunoreactivity for chromogranin and synaptophysin.
  • [MeSH-major] Adenoma / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adult. Chorionic Gonadotropin / therapeutic use. Chromogranins / metabolism. Clomiphene / therapeutic use. Female. Fertility Agents, Female / therapeutic use. Headache / etiology. Humans. Immunohistochemistry. Infertility, Female / drug therapy. Magnetic Resonance Imaging. Synaptophysin / metabolism. Vision Disorders / etiology

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  • (PMID = 18207654.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin; 0 / Chromogranins; 0 / Fertility Agents, Female; 0 / Synaptophysin; 1HRS458QU2 / Clomiphene
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11. Trimarchi CP, Russo P: Cyclic estrogen-progestin hormone therapy as a new therapeutic approach in the treatment of functional alterations of the hypothalamus-pituitary-ovary axis: case reports. Endocr Res; 2002 Aug;28(3):155-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclic estrogen-progestin hormone therapy as a new therapeutic approach in the treatment of functional alterations of the hypothalamus-pituitary-ovary axis: case reports.
  • We report a first case of a 30 year-old woman affected by polycystic ovarian disease (PCOD) whose amenorrhea ceased after a 6-month combination treatment with cyclic estradiol-norethisterone acetate.
  • After the withdrawal of the hormone therapy, a stable recovery of periodic menses was observed.
  • We describe a second case of a 23 year-old woman whose amenorrhea was caused by a hypogonadotropic hypogonadism due to a non-functioning pituitary adenoma.
  • After the administration of the previously described therapy both a disappearance of the adenoma and a recover of periodic menses were observed.
  • The exogenous hormones may have reset the feedback between the hypothalamus and pituitary gland through mimicking the physiological hormones pattern of the 28-day cycle.
  • [MeSH-major] Adenoma / complications. Amenorrhea / drug therapy. Estradiol / administration & dosage. Norethindrone / administration & dosage. Norethindrone / analogs & derivatives. Pituitary Neoplasms / complications. Polycystic Ovary Syndrome / complications
  • [MeSH-minor] Adult. Drug Administration Schedule. Drug Therapy, Combination. Feedback. Female. Humans. Hypogonadism / complications. Hypothalamus / drug effects. Hypothalamus / physiopathology. Ovary / physiopathology. Pituitary Gland / drug effects. Pituitary Gland / physiopathology

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  • (PMID = 12489565.001).
  • [ISSN] 0743-5800
  • [Journal-full-title] Endocrine research
  • [ISO-abbreviation] Endocr. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4TI98Z838E / Estradiol; 9S44LIC7OJ / norethindrone acetate; T18F433X4S / Norethindrone
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12. Guerra Y, Lacuesta E, Marquez F, Raksin PB, Utset M, Fogelfeld L: Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. Pituitary; 2010;13(1):54-9
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  • [Title] Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer.
  • We report the case of a 60 year old male who complained of headache and blurry vision--that progressed to left ophthalmoplegia and ptosis--after receiving a dose of leuprolide for Prostate cancer therapy.
  • The patient underwent transsphenoidal debulking, and the tissue obtained demonstrated immunohistochemical staining for LH.
  • A literature review revealed nine previously reported cases of pituitary apoplexy after GnRH agonist therapy for prostate cancer.
  • In most cases, the sellar tissues stained for LH, consistent with a gonadotropinoma.
  • Particular attention to clinical findings suggestive of a non functioning pituitary tumor in patients receiving GnRH agonist therapy is critical as routine screening with MRI is not practical.
  • [MeSH-major] Adenoma / complications. Leuprolide / adverse effects. Pituitary Neoplasms / complications. Stroke / chemically induced
  • [MeSH-minor] Antineoplastic Agents, Hormonal / adverse effects. Gonadotropin-Releasing Hormone / agonists. Humans. Male. Middle Aged. Prostatic Neoplasms / complications. Prostatic Neoplasms / drug therapy. Sella Turcica


13. Colao A, Dorato M, Pulcrano M, Rossi FW, Auriemma RS, Lombardi G, Lastoria S: [Somatostatin analogs in the clinical management of pituitary neoplasms]. Minerva Endocrinol; 2001 Sep;26(3):181-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Somatostatin analogs in the clinical management of pituitary neoplasms].
  • The medical approach to patients with secreting or clinically non-functioning pituitary adenoma as made considerable progress thanks to the use of new somatostatin analogs.
  • Good results were obtained using slow-release analog treatment also in TSH-secreting adenomas, whereas the therapeutic efficacy of these peptides in clinically non-functioning adenomas is still controversial.
  • Treatment with somatostatin analogs improves symptoms, normalises hormone secretion and in some cases may induce a reduction in the volume of pituitary adenomas.
  • Scintigraphy with octreotide may help to select patients who respond to this form of treatment.
  • [MeSH-major] Adenoma / drug therapy. Antineoplastic Agents, Hormonal / therapeutic use. Octreotide / analogs & derivatives. Octreotide / therapeutic use. Pentetic Acid / analogs & derivatives. Peptides, Cyclic / therapeutic use. Pituitary Neoplasms / drug therapy. Somatostatin / therapeutic use
  • [MeSH-minor] Acromegaly / drug therapy. Adolescent. Adrenal Gland Neoplasms / radionuclide imaging. Adult. Aged. Carcinoma / radionuclide imaging. Humans. Indium Radioisotopes / therapeutic use. Insulin-Like Growth Factor I / secretion. Kidney Neoplasms / radionuclide imaging. Melanoma / radionuclide imaging. Middle Aged. Pheochromocytoma / radionuclide imaging. Predictive Value of Tests. Prolactinoma / drug therapy. Radiopharmaceuticals / therapeutic use. Sensitivity and Specificity. Thymoma / radionuclide imaging. Thymus Neoplasms / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging. Thyrotropin / secretion. Treatment Outcome

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  • (PMID = 11753242.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Indium Radioisotopes; 0 / Peptides, Cyclic; 0 / Radiopharmaceuticals; 118992-92-0 / lanreotide; 142694-57-3 / SDZ 215-811; 51110-01-1 / Somatostatin; 67763-96-6 / Insulin-Like Growth Factor I; 7A314HQM0I / Pentetic Acid; 9002-71-5 / Thyrotropin; RWM8CCW8GP / Octreotide
  • [Number-of-references] 95
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14. Kreitschmann-Andermahr I, Poll EM, Reineke A, Gilsbach JM, Brabant G, Buchfelder M, Fassbender W, Faust M, Kann PH, Wallaschofski H: Growth hormone deficient patients after traumatic brain injury--baseline characteristics and benefits after growth hormone replacement--an analysis of the German KIMS database. Growth Horm IGF Res; 2008 Dec;18(6):472-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All 84 TBI patients were matched with 84 patients with GHD due to non-functioning pituitary adenoma (NFPA) also included in this database.
  • Analysis of clinical and outcome variables was performed, with comparisons of childhood vs. adult TBI, and TBI vs. NFPA patients, at baseline and one-year follow-up.
  • RESULTS: TBI patients with GHD were significantly younger at the onset of pituitary disease and exhibited a significantly longer time span between GHD diagnosis and KIMS entry than NFPA patients.
  • At 1-year follow-up, insulin-like growth factor I (IGF-I) standard deviation score levels had returned to the normal range and quality of life (QoL), as measured by QoL- Assessment of Growth Hormone Deficiency in Adults (AGHDA) questionnaire, improved significantly in TBI as in NFPA patients.
  • CONCLUSION: This analysis provides preliminary data that TBI patients with GHD benefit from hGH replacement in terms of improved QoL in a similar fashion as do NFPA patients.
  • Moreover, it suggests that belated diagnosis and treatment in childhood-onset GHD due to TBI might be related to a shorter final height in these children.
  • [MeSH-major] Brain Injuries / physiopathology. Databases, Factual. Human Growth Hormone / therapeutic use
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Germany. Hormone Replacement Therapy. Humans. Hypopituitarism / complications. Hypopituitarism / drug therapy. Hypopituitarism / physiopathology. Male. Middle Aged. Pituitary Neoplasms / complications. Pituitary Neoplasms / drug therapy. Pituitary Neoplasms / physiopathology

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  • (PMID = 18829359.001).
  • [ISSN] 1532-2238
  • [Journal-full-title] Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • [ISO-abbreviation] Growth Horm. IGF Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
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15. Wu ZB, Chen Y, Lü QP, Wang CD, Su ZP, Wu JS, Zheng WM, Zhuge QC: [Natural history study of postoperative residual non-functioning pituitary adenomas]. Zhonghua Yi Xue Za Zhi; 2010 Mar 9;90(9):597-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Natural history study of postoperative residual non-functioning pituitary adenomas].
  • OBJECTIVE: To observe the postoperative residual non-functioning pituitary adenomas (PR-NFPAs) without postoperative radiotherapy and to analyze the natural history of PR-NFPAs' growth in order to provide a basis for selecting appropriate strategies of clinical treatment.
  • METHODS: We evaluated the natural history of 20 patients with PR-NFPAs who did not receive postoperative radiotherapy and drug therapy.
  • Through MRI images, the residual tumor volumes of those patients were serially measured.
  • We further calculated the monthly growth rate and the tumor volume doubling time (TVDT) and analyzed the correlations between the patient age, gender, volume of residual tumor, cavernous sinus (CS) invasion and TVDT.
  • Among which, 17 adenomas increased in volume and 3 remained unchanged during a follow-up period of 7 months to 17 years (mean 3.90 yr).
  • As to 17 patients with tumor regrowth, the tumor volume at the beginning of MRI observation period was 4.73 cm(3) and tumor volume at the last MRI observation was 16.98 cm(3).
  • Such factors as patient age, gender, volume of residual tumor and CS invasion did not affect the TVDT of PR-NFPAs.
  • CONCLUSION: The tumor growth rate of PR-NFPAs is not significantly correlated with the patient gender, age, volume of residual tumor and CS invasion.
  • In conjunctions with the volume of PR-NFPAs and the distance between residual adenoma and optic chiasm, we should take the TVDT into consideration and determine the appropriate and safe follow-up period.
  • [MeSH-major] Adenoma / pathology. Neoplasm, Residual / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Postoperative Period. Young Adult

  • MedlinePlus Health Information. consumer health - Pituitary Tumors.
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  • (PMID = 20450781.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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