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1. Voutsadakis IA: Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2. J Cell Mol Med; 2007 Mar-Apr;11(2):252-85
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  • [Title] Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.
  • Inhibition of Cox-2 by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been found to inhibit proliferation of colorectal cancer cells and in epidemiologic studies has been shown to reduce colon polyp formation in genetically predisposed populations and in the general population.
  • Targeted therapies, the result of increasingly understanding carcinogenesis in the molecular level, have entered the field of anti-neoplastic treatment and are used by themselves and in combination with chemotherapy drugs.
  • Combinations of targeted drugs have started also to be investigated.
  • This article reviews the molecular pathogenesis of colorectal cancer, the roles of UPS and Cox-2 in it and puts forward a rational for their combined inhibition in colorectal cancer treatment.
  • [MeSH-major] Carcinoma / therapy. Colorectal Neoplasms / therapy. Cyclooxygenase 2 / metabolism. Cyclooxygenase Inhibitors / therapeutic use. Proteasome Endopeptidase Complex / metabolism. Ubiquitin / metabolism

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  • (PMID = 17488476.001).
  • [ISSN] 1582-1838
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors; 0 / Ubiquitin; EC 1.14.99.1 / Cyclooxygenase 2; EC 3.4.25.1 / Proteasome Endopeptidase Complex
  • [Number-of-references] 298
  • [Other-IDs] NLM/ PMC3822826
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2. Imperiale TF, Wagner DR, Lin CY, Larkin GN, Rogge JD, Ransohoff DF: Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med; 2000 Jul 20;343(3):169-74
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  • [Title] Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings.
  • BACKGROUND AND METHODS: The clinical significance of a distal colorectal polyp is uncertain.
  • We determined the risk of advanced proximal neoplasia, defined as a polyp with villous features, a polyp with high-grade dysplasia, or cancer, among persons with distal hyperplastic or neoplastic polyps as compared with the risk among persons with no distal polyps.
  • We analyzed data from 1994 consecutive asymptomatic adults (age, 50 years or older) who underwent colonoscopic screening for the first time between September 1995 and December 1998 as part of a program sponsored by an employer.
  • RESULTS: Sixty-one patients (3.1 percent) had advanced lesions in the distal colon, including 5 with cancer, and 50 (2.5 percent) had advanced proximal lesions, including 7 with cancer.
  • Twenty-three patients with advanced proximal neoplasms (46 percent) had no distal polyps.
  • The prevalence of advanced proximal neoplasia among patients with no distal polyps was 1.5 percent (23 cases among 1564 persons; 95 percent confidence interval, 0.9 to 2.1 percent).
  • Among patients with distal hyperplastic polyps, those with distal tubular adenomas, and those with advanced distal polyps, the prevalence of advanced proximal neoplasia was 4.0 percent (8 cases among 201 patients), 7.1 percent (12 cases among 168 patients), and 11.5 percent (7 cases among 61 patients), respectively.
  • The relative risk of advanced proximal neoplasia, adjusted for age and sex, was 2.6 for patients with distal hyperplastic polyps, 4.0 for those with distal tubular adenomas, and 6.7 for those with advanced distal polyps, as compared with patients who had no distal polyps.
  • CONCLUSIONS: Asymptomatic persons 50 years of age or older who have polyps in the distal colon are more likely to have advanced proximal neoplasia than are persons without distal polyps.
  • However, if colonoscopic screening is performed only in persons with distal polyps, about half the cases of advanced proximal neoplasia will not be detected.

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  • [CommentIn] N Engl J Med. 2000 Nov 30;343(22):1651; author reply 1652-4 [11184981.001]
  • [CommentIn] N Engl J Med. 2000 Nov 30;343(22):1652-4 [11184982.001]
  • [CommentIn] N Engl J Med. 2000 Nov 30;343(22):1651-2; author reply 1652-4 [11184980.001]
  • (PMID = 10900275.001).
  • [ISSN] 0028-4793
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K24 DK02756-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
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3. Song J, Sohn KJ, Medline A, Ash C, Gallinger S, Kim YI: Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice. Cancer Res; 2000 Jun 15;60(12):3191-9
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  • A recently developed murine model of intestinal tumorigenesis, which carries a heterozygous mutation in the Apc gene and a null mutation in the Msh2 gene (Apc+/-Msh2-/-), was used to determine the effect of dietary folate on intestinal tumorigenesis.
  • The 3- and 6-week diet starts represent intervention before and after the establishment of neoplastic foci, respectively.
  • Microsatellite instability was determined in matched normal and polyp DNA from the small intestine and colon at 5 loci.
  • Folate supplementation, started before the establishment of neoplastic foci, significantly decreased the number of small intestinal adenomas (by 2.7-fold; P = 0.004) and colonic ACF (by 2.8-fold; P = 0.028) and colonic adenomas (by 2.8-fold; P = 0.1) compared with a moderate degree of folate deficiency.
  • In contrast, a moderately folate-deficient diet, started after the establishment of neoplastic foci, significantly reduced the number of small intestinal adenomas (by 4.2-fold; P = 0.001) but had no effect on colonic ACF and adenomas compared with folate supplementation.
  • In conclusion, in this murine model, dietary folate supplementation significantly protects against small intestinal and colorectal tumorigenesis if it is provided before the establishment of neoplastic foci However, if it is provided after the establishment of neoplastic foci, dietary folate seems to have an opposite effect.
  • [MeSH-major] Colorectal Neoplasms / prevention & control. DNA-Binding Proteins. Diet. Folic Acid / therapeutic use. Intestinal Polyps / drug therapy. Intestinal Polyps / prevention & control
  • [MeSH-minor] Adenoma / prevention & control. Adenomatous Polyposis Coli Protein. Age Factors. Animals. Body Weight / drug effects. Colon / drug effects. CpG Islands / genetics. Cytoskeletal Proteins / genetics. Intestine, Small / drug effects. Methylation. Mice. Mice, Inbred C57BL. Microsatellite Repeats. MutS Homolog 2 Protein. Precancerous Conditions / drug therapy. Precancerous Conditions / prevention & control. Proto-Oncogene Proteins / genetics

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  • (PMID = 10866310.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Cytoskeletal Proteins; 0 / DNA-Binding Proteins; 0 / Proto-Oncogene Proteins; 935E97BOY8 / Folic Acid; EC 3.6.1.3 / Msh2 protein, mouse; EC 3.6.1.3 / MutS Homolog 2 Protein
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4. Rao CV, Swamy MV, Patlolla JM, Kopelovich L: Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice. Cancer Res; 2008 Sep 15;68(18):7670-5
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  • The styrylquinazoline CP-31398 can rescue destabilized mutant p53 expression and promote activity of wild-type p53.
  • Effects of CP-31398 on early-stage adenomas were determined by feeding 7-week-old female C57BL/6J-APC(min) (heterozygous) and wild-type C57BL/6J mice with American Institute of Nutrition-76A diets containing 0, 100, or 200 ppm of CP-31398 for 75 days.
  • During late-stage intervention, CP-31398 also significantly suppressed intestinal polyp formation, albeit to a lesser extent than observed with early intervention.
  • These observations show for the first time that the p53-modulating agent CP-31398 possesses significant chemopreventive activity in vivo against intestinal neoplastic lesions in genetically predisposed APC(min/+) mice.

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  • (PMID = 18794156.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CN / N01-CN-25114; United States / NCI NIH HHS / CA / R01 CA094962; United States / NCI NIH HHS / CA / R01 CA094962-05; United States / NCI NIH HHS / CA / CA094962-05; United States / NCI NIH HHS / CA / NCI-CA-94962
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CP 31398; 0 / Cdkn1a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Pyrimidines; 0 / Tumor Suppressor Protein p53; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / Caspase 3
  • [Other-IDs] NLM/ NIHMS60489; NLM/ PMC2597360
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5. Ohwada M, Suzuki M, Hironaka M, Irie T, Sato I: Neuroendocrine small cell carcinoma of the uterine cervix showing polypoid growth and complicated by pregnancy. Gynecol Oncol; 2001 Apr;81(1):117-9
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  • No polyp had been detected at 14 weeks of gestation.
  • The polyp was excised and diagnosed as neuroendocrine small cell carcinoma by histological examination, including Grimelius, neuron-specific enolase, and chromogranin staining.
  • After surgery, four cycles of combination chemotherapy with cisplatin and etoposide were administered, and the patient is disease-free as of 13 months after surgery.
  • CONCLUSION: When a polypoid lesion is found, especially when it demonstrates rapid growth, it may be necessary to excise and histologically examine the polyp even during pregnancy.
  • [MeSH-major] Carcinoma, Neuroendocrine / pathology. Carcinoma, Small Cell / pathology. Pregnancy Complications, Neoplastic / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Division / physiology. Female. Humans. Polyps / drug therapy. Polyps / pathology. Polyps / surgery. Pregnancy


6. Chmiel B, Nocoń G: [Secondary primary, bilocal sigmoid colon adenocarcinoma in a patient previously treated for testicular cancer]. Wiad Lek; 2004;57(5-6):288-9
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  • Frequency of neoplastic diseases among patients cured successfully from testicular cancer is higher than in normal population.
  • The patient underwent nearly total colectomy and resection of the rectal polyp.
  • Six months after operation patient did not present any features of neoplastic disease.
  • This case is an illustration of the problem of cancerogenesis within polyps of the large bowel in patients treated before by chemotherapy because of testicular cancer.
  • [MeSH-minor] Humans. Male. Middle Aged. Time Factors. Treatment Outcome

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  • (PMID = 15518079.001).
  • [ISSN] 0043-5147
  • [Journal-full-title] Wiadomości lekarskie (Warsaw, Poland : 1960)
  • [ISO-abbreviation] Wiad. Lek.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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7. Li WW, Yau TN, Leung CW, Pong WM, Chan MY: Large-cell neuroendocrine carcinoma of the uterine cervix complicating pregnancy. Hong Kong Med J; 2009 Feb;15(1):69-72
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  • Large-cell neuroendocrine cervical carcinoma is a rare and aggressive cancer that tends to spread and recur early despite intensive multimodal treatment.
  • The optimal mode of therapy is still controversial and management during pregnancy is challenging because foetal well-being must also be considered.
  • We report a patient with clinically stage IIB large-cell neuroendocrine cervical carcinoma who presented with a cervical polyp and vaginal bleeding at 18 weeks of pregnancy.
  • The patient received concurrent chemotherapy and radiation after termination of pregnancy and remained in complete remission 21 months after completion of treatment.


8. Goldstein PJ, Cabanas J, da Silva RG, Sugarbaker PH: Pseudomyxoma peritonei arising from colonic polyps. Eur J Surg Oncol; 2006 Sep;32(7):764-6
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  • This manuscript describes this disease arising from a benign or malignant colonic polyp.
  • METHODS: From a database of over 1000 pseudomyxoma peritonei patients and colorectal carcinomatosis patients, three cases were identified in which the primary tumor site was a colonic polyp.
  • RESULTS: In a review of the clinical management of these patients, all three had an event whereby neoplastic cells from the surface of the colonic polyp could have gained access to the free peritoneal cavity.
  • The patients developed the characteristic pseudomyxoma peritonei syndrome.
  • All three patients were treated with cytoreductive surgery plus perioperative hyperthermic intraperitoneal chemotherapy.
  • If pseudomyxoma peritonei develops, cytoreductive surgery and perioperative intraperitoneal chemotherapy should be considered for treatment.

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  • (PMID = 16765563.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Kuhne HP, Göller T, Schneider I, Bozkurt T, Becker HP: [Unclear per anum bleeding during pregnancy]. Chirurg; 2005 Aug;76(8):765-8
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  • Rectoscopy showed the cause to be a polyp the size of a fingertip 9 cm from the anus.
  • Seeking a prognosis optimal for the newborn child, the interdisciplinary decision was made for primary surgery with adjuvant chemotherapy.
  • [MeSH-major] Intestinal Polyps / diagnosis. Melena / etiology. Neuroendocrine Tumors / diagnosis. Pregnancy Complications / etiology. Pregnancy Complications, Neoplastic / diagnosis. Puerperal Disorders / diagnosis. Rectal Neoplasms / diagnosis


10. Mbatsogo BA, Le Bouëdec G, Michy T, Bourdel N, Fouilloux G, Dauplat J: [Endometrial cancers arising in polyps associated with tamoxifen use]. Gynecol Obstet Fertil; 2005 Dec;33(12):975-9
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  • RESULTS: A malignant transformation of polyp was found in 5 instances, meaning a rate of 4.6% i.e.
  • DISCUSSION AND CONCLUSION: The existence of endometrial polyps - symptomatic or not - does not seem compatible with the prolonged use of tamoxifen treatment owing the estrogen agonist potential effects of tamoxifen and its well-known hyperplastic and carcinogenic properties for the endometrium.
  • [MeSH-major] Antineoplastic Agents, Hormonal / adverse effects. Cell Transformation, Neoplastic / chemically induced. Endometrial Neoplasms / chemically induced. Polyps / pathology. Tamoxifen / adverse effects
  • [MeSH-minor] Aged. Aged, 80 and over. Breast Neoplasms / drug therapy. Female. Humans. Middle Aged. Risk Factors

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  • (PMID = 16321556.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen
  • [Number-of-references] 44
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11. Shailubhai K, Yu HH, Karunanandaa K, Wang JY, Eber SL, Wang Y, Joo NS, Kim HD, Miedema BW, Abbas SZ, Boddupalli SS, Currie MG, Forte LR: Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Cancer Res; 2000 Sep 15;60(18):5151-7
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  • [Title] Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP.
  • Oral replacement therapy with human uroguanylin was used to evaluate its effects on the formation of intestinal polyps in the Min/+ mouse model for colorectal cancer.
  • The intestinal R-GC signaling molecules for guanylin regulatory peptides are promising targets for prevention and/or therapeutic treatment of intestinal polyps and cancers by oral administration of human uroguanylin.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyposis Coli / prevention & control. Apoptosis / drug effects. Colonic Neoplasms / pathology. Cyclic GMP / physiology. Gastrointestinal Hormones. Peptides / pharmacology
  • [MeSH-minor] Aged. Aged, 80 and over. Amino Acid Sequence. Animals. Caco-2 Cells / drug effects. Down-Regulation / drug effects. Female. Gene Expression Regulation, Neoplastic / drug effects. Humans. Male. Mice. Mice, Inbred C57BL. Middle Aged. Molecular Sequence Data. Natriuretic Peptides. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Receptors, Cell Surface / biosynthesis. Receptors, Cell Surface / genetics. Receptors, Cell Surface / physiology. Tumor Cells, Cultured

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  • (PMID = 11016642.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Gastrointestinal Hormones; 0 / Natriuretic Peptides; 0 / Peptides; 0 / RNA, Messenger; 0 / Receptors, Cell Surface; 140653-38-9 / guanylin; 152175-68-3 / uroguanylin; H2D2X058MU / Cyclic GMP
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12. Yamamasu S, Nakai Y, Nishio J, Hyun Y, Honda KI, Hirai K, Ishiko O, Ogita S: Conservative management of placental polyp with oral administration of methotrexate. Oncol Rep; 2001 Sep-Oct;8(5):1031-3
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  • [Title] Conservative management of placental polyp with oral administration of methotrexate.
  • Surgical treatment is usually selected for placental polyp accompanied by massive bleeding but patients wishing to conserve their fecundity require conservative management.
  • A 35-year old nullipara was diagnosed as having placental polyp on the basis of typical episodes, and detection of placental polypeptide hormones and blood flow by Doppler ultrasonography and dynamic magnetic resonance imaging.
  • Oral administration of methotrexate (2.5 mg, three times a day for 5 days) was repeated for three cycles because surgical treatment was rejected.
  • Serum human placental lactogen, blood flow and the polyp disappeared sequentially following chemotherapy.
  • This report thus advocates considering conservative management for placental polyp.
  • [MeSH-major] Antimetabolites, Antineoplastic / administration & dosage. Methotrexate / administration & dosage. Placenta Diseases / drug therapy. Polyps / drug therapy. Pregnancy Complications, Neoplastic / drug therapy

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  • (PMID = 11496311.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Chorionic Gonadotropin; YL5FZ2Y5U1 / Methotrexate
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13. Niv Y: Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancer. World J Gastroenterol; 2007 Mar 28;13(12):1767-9
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  • They are more prevalent in the proximal colon and have a fast pass from polyp to cancer.
  • Resistance of colorectal cancers with a high frequency of microsatellite instability to 5-fluorouracil-based chemotherapy is well established.
  • Better knowledge of this process will have a huge impact on colorectal cancer management, prevention, treatment and prognosis.
  • [MeSH-minor] Cell Proliferation. DNA Methylation. DNA, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Gene Silencing. Humans. Promoter Regions, Genetic / genetics

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  • (PMID = 17465465.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / Nuclear Proteins
  • [Number-of-references] 24
  • [Other-IDs] NLM/ PMC4149951
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14. Morimoto LM, Newcomb PA, Ulrich CM, Bostick RM, Lais CJ, Potter JD: Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? Cancer Epidemiol Biomarkers Prev; 2002 Oct;11(10 Pt 1):1012-8
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  • Cases with hyperplastic polyps (n = 219), adenomas (n = 437), and both types of polyps (n = 138), along with colonoscopy-negative controls (n = 708), were identified at a gastroenterology practice in the Minneapolis area during 1991-1994.
  • Male sex, smoking, and alcohol consumption were associated with increased risk of all polyp groups; nonsteroidal anti-inflammatory drug use, hormone replacement therapy use, and calcium intake were associated with reduced risk.
  • There was no apparent association between increasing age and hyperplastic polyp risk (P = 0.21) in this analysis, although it was a strong risk factor for adenoma (P < 0.001).
  • The OR estimate for individuals diagnosed with both polyp types was 4.2 (95% CI, 1.9-9.3).
  • To the contrary, individuals with both polyp types may be expressing a phenotype distinct from those who have only adenomas and should be considered separately.
  • Further studies are necessary to establish which polyp phenotypes are related to smoking.
  • Overall, the similarity of the risk profiles of colorectal hyperplastic polyps, adenoma, and cancer provides additional support for the growing body of evidence that some hyperplastic polyps may have neoplastic potential.
  • [MeSH-minor] Adult. Aged. Alcohol Drinking / adverse effects. Anti-Inflammatory Agents, Non-Steroidal / adverse effects. Case-Control Studies. Female. Hormone Replacement Therapy / adverse effects. Humans. Hyperplasia. Male. Middle Aged. Phenotype. Risk Factors. Sex Factors

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  • (PMID = 12376501.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5-T32-CA09168; United States / NIEHS NIH HHS / ES / ES-07033; United States / NCI NIH HHS / CA / P01 CA 50405; United States / NCI NIH HHS / CA / T32 CA09661
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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15. Goel A, Fuerst F, Hotchkiss E, Boland CR: Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells. Cancer Biol Ther; 2006 May;5(5):529-35
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  • While there is an increasing interest in selenium chemoprevention against human colon polyp recurrence and other cancers, the mechanism(s) by which these agents inhibit carcinogenesis are uncertain.
  • However, the molecular mechanisms of action of selenomethionine, an organoselenium compound present in selenized yeast and currently being investigated in human clinical trials for colon polyp prevention, are unclear.
  • Four human colon cancer cell lines including HCT116 and RKO (wild type p53), HCT116-p53KO (isogenic control of HCT116 cells with p53 knocked out) and Caco-2 (mutant p53) were treated with 0-100 microM of selenomethionine for 24, 48 and 72 h.
  • All cell lines showed concentration and time dependent growth inhibition with selenomethionine, although HCT116 and RKO cells were the most sensitive to such treatments.
  • Cell cycle arrest and apoptosis observed in HCT116 and RKO cell lines were accompanied by a marked increase in p53 protein expression following selenium treatment.
  • [MeSH-major] Apoptosis / drug effects. Cell Division / drug effects. Colonic Neoplasms / metabolism. G2 Phase / drug effects. Selenomethionine / pharmacology. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Blotting, Western. Cell Proliferation / drug effects. Fluorescent Antibody Technique. Gene Expression Regulation, Neoplastic. Humans. Tumor Cells, Cultured

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  • (PMID = 16627976.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA 72851
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; 964MRK2PEL / Selenomethionine
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16. Chandacham A, Kietpeerakool C, Khunamornpong S, Suprasert P, Srisomboon J, Charoenkwan K, Phongnarisorn C, Cheewakraingkrai C, Siriaree S, Tantipalakorn C: Successfully conservative treatment of large cervical choriocarcinoma with profuse vaginal bleeding. J Med Assoc Thai; 2009 Jan;92(1):120-3
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  • [Title] Successfully conservative treatment of large cervical choriocarcinoma with profuse vaginal bleeding.
  • Furthermore, the majority of cases presented with abnormal vaginal bleeding that could be caused by other more common conditions including, threatened abortion, cervical polyp, cervical pregnancy, or cervical cancer.
  • Remission of cervical choriocarcinoma was accomplished with combination chemotherapy without the need of hysterectomy.
  • [MeSH-major] Choriocarcinoma / therapy. Pregnancy Complications, Neoplastic / therapy. Uterine Neoplasms / therapy
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cytarabine / administration & dosage. Diagnosis, Differential. Embolization, Therapeutic. Etoposide / administration & dosage. Female. Humans. Mitoxantrone / administration & dosage. Pregnancy. Ultrasonography, Doppler, Color

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  • (PMID = 19260253.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 6PLQ3CP4P3 / Etoposide; BZ114NVM5P / Mitoxantrone; MEA protocol
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17. Rossi G, Bonacorsi G, Longo L, Artusi T, Rivasi F: Primary high-grade mucosa-associated lymphoid tissue-type lymphoma of the cervix presenting as a common endocervical polyp. Arch Pathol Lab Med; 2001 Apr;125(4):537-40
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  • [Title] Primary high-grade mucosa-associated lymphoid tissue-type lymphoma of the cervix presenting as a common endocervical polyp.
  • We describe a rare case of primary high-grade lymphoma of mucosa-associated lymphoid tissue of the uterine cervix in a 46-year-old white woman.
  • The tumor, incidentally disclosed at gynecological examination, appeared as a single common polyp.
  • The neoplastic cells did not stain for CD5, CD10, CD23, CD43, or cyclin D1.
  • The tumor was successfully treated by multiagent chemotherapy followed by total hysterectomy.
  • To our knowledge, this case represents the second reported example of mucosa-associated lymphoid tissue-type lymphoma occurring in the uterine cervix.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Bleomycin. Cyclophosphamide. Cytarabine. Diagnosis, Differential. Epirubicin. Etoposide. Female. Humans. Hysterectomy. Immunohistochemistry. In Situ Hybridization. Methotrexate. Middle Aged. Neoplasm Proteins / analysis. Prednisone. Vincristine


18. Bese T, Simsek Y, Bese N, Ilvan S, Arvas M: Extensive pelvic endometriosis with malignant change in tamoxifen-treated postmenopausal women. Int J Gynecol Cancer; 2003 May-Jun;13(3):376-80
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  • A 74-year-old woman with a history of breast carcinoma who received tamoxifen therapy for 2 years was admitted with uterine bleeding.
  • Hysteroscopic polypectomy revealed a hyperplastic polyp.
  • As cervical cancer occurred in a short period, it might be speculated that tamoxifen might have stimulated the proliferative and mitotic activity of cervical endometrial tissue which has progressed into invasive cancer in time.
  • [MeSH-major] Adenocarcinoma / chemically induced. Adnexal Diseases / complications. Antineoplastic Agents, Hormonal / adverse effects. Cell Transformation, Neoplastic / chemically induced. Endometriosis / complications. Tamoxifen / adverse effects. Uterine Cervical Neoplasms / chemically induced
  • [MeSH-minor] Aged. Breast Neoplasms / drug therapy. Female. Gynecologic Surgical Procedures / methods. Humans. Pelvis. Postmenopause






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