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1. Nitta T, Koike H, Fukabori Y, Hatori M, Ono Y, Matsui H, Suzuki K, Yamanaka H, Shigawa Y, Kanazawa T, Ogawa C: [Acute scrotum from testicular involvement in acute lymphocytic leukemia: a case report]. Nihon Hinyokika Gakkai Zasshi; 2004 Jul;95(5):722-4
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  • [Title] [Acute scrotum from testicular involvement in acute lymphocytic leukemia: a case report].
  • A 8-year-old boy with acute lymphocytic leukemia (ALL) had received chemotherapy and a complete bone marrow remission was obtained.
  • Sequentially, he had swelling and redness of left scrotum, left testicular swelling and tenderness.
  • Incision was done and enlarged and hard testis was diagnosed as testicular tumor, left orchiectomy was performed.
  • Histological diagnosis was involvement of ALL, so he received radiotherapy.
  • [MeSH-major] Bone Marrow Transplantation. Genital Diseases, Male / etiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Scrotum. Testicular Neoplasms / pathology
  • [MeSH-minor] Child. Humans. Male. Neoplasm Invasiveness. Orchiectomy

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  • (PMID = 15354719.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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2. Beleznay KM, Levesque MA, Gill S: Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain. Curr Oncol; 2009 Sep;16(5):81-3

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  • [Title] Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain.
  • Extramammary Paget disease is a rare intraepithelial neoplasm of the vulvar, penoscrotal, or perianal skin.
  • No effective therapies for metastatic disease have been reported, and prognosis for metastatic disease is poor.Here, we report the case of an Asian man who was initially diagnosed with extramammary Paget disease of the scrotum.
  • After an extensive work-up, biopsies of liver and bone marrow revealed adenocarcinoma with signet cells and immunohistochemical staining positive for keratin 7, carcinoembryonic antigen, and prolactin-induced protein, but negative for keratin 20, S100, and prostate markers, consistent with his previous biopsyproven Paget disease of the scrotum.
  • The patient was treated with 5-fluorouracil-based therapy in addition to palliative radiotherapy to selected spine levels.
  • A promising palliative response was demonstrated following 5-fluorouracil chemotherapy.A review of the literature on the pathogenesis, diagnosis, treatment options, and outcomes for metastatic extramammary Paget disease is presented.

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  • [Cites] Dermatol Surg. 2004 Feb;30(2 Pt 2):341-4 [14871231.001]
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  • (PMID = 19862365.001).
  • [ISSN] 1718-7729
  • [Journal-full-title] Current oncology (Toronto, Ont.)
  • [ISO-abbreviation] Curr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2768510
  • [Keywords] NOTNLM ; 5-fluorouracil / Paget disease / extramammary / metastatic
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3. Acar O, Akinci M, Uluocak N, Akbulut F, Kilicaslan I, Gokce O: Paratesticular metastasis of malignant melanoma: a case report. Kaohsiung J Med Sci; 2008 Jun;24(6):315-8
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  • After preliminary evaluation, he was referred to our clinic due to a right scrotal mass.
  • He was referred to the oncology department for adjuvant treatment.
  • The patient died during the third month of chemotherapy.
  • Our case was unique because the malignant melanoma was widely metastatic and involved primarily paratesticular tissues without any invasion of the testis and epididymis.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Genital Neoplasms, Male / secondary. Melanoma / diagnosis. Melanoma / pathology. Scrotum / pathology
  • [MeSH-minor] Back Pain. Biopsy. Epididymis / pathology. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Testis / pathology. Tomography, X-Ray Computed

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  • (PMID = 18635417.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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4. Philip J, Armitage DW, Phillips KR, Parr NJ: Leech therapy for penoscrotal oedema in patients with hormone-refractory prostate carcinoma. BJU Int; 2003 Apr;91(6):579-80
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  • [Title] Leech therapy for penoscrotal oedema in patients with hormone-refractory prostate carcinoma.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Edema / therapy. Leeching. Prostatic Neoplasms / drug therapy. Scrotum
  • [MeSH-minor] Aged. Drug Resistance, Neoplasm. Humans. Male

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  • (PMID = 12656920.001).
  • [ISSN] 1464-4096
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal
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5. Akramipour R, Zargooshi J, Rahimi Z: Infant with concomitant presence of hernia/hydrocele and primary paratesticular neuroblastoma: a diagnostic and therapeutic challenge. J Pediatr Hematol Oncol; 2009 May;31(5):349
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  • [Title] Infant with concomitant presence of hernia/hydrocele and primary paratesticular neuroblastoma: a diagnostic and therapeutic challenge.
  • We report an 8-month-old boy with stage 1 neuroblastoma, whose "testicular tumor" was removed during a "radical orchiectomy" by a pediatric surgeon who encountered a scrotal mass during a hernia repair.
  • Pathologic examination of the specimen suggested seminoma and the surgeon sent the patient for cisplatin-based chemotherapy.
  • The patient is tumor free after 36 months of follow-up.
  • This case shows that in presence of hernia, distorted anatomy, and inguinal testis, paratesticular tumors can be misdiagnosed for the testis and cause great diagnostic and therapeutic difficulty.
  • [MeSH-major] Genital Neoplasms, Male / complications. Genital Neoplasms, Male / pathology. Hernia, Inguinal / complications. Neuroblastoma / complications. Neuroblastoma / pathology. Testicular Hydrocele / complications
  • [MeSH-minor] Diagnostic Errors. Female. Humans. Male. Neoplasm Staging. Orchiectomy. Scrotum / pathology. Scrotum / surgery. Testis / blood supply. Testis / cytology. Testis / surgery

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  • (PMID = 19415016.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Sánchez-Ortiz R, Huang SF, Tamboli P, Prieto VG, Hester G, Pettaway CA: Melanoma of the penis, scrotum and male urethra: a 40-year single institution experience. J Urol; 2005 Jun;173(6):1958-65
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  • [Title] Melanoma of the penis, scrotum and male urethra: a 40-year single institution experience.
  • In addition, we present what is to our knowledge the largest reported series of melanoma of the scrotum (6 cases).
  • One patient died of melanoma that developed at a second primary site.
  • Six patients with scrotal melanoma were treated with WLE without local recurrences.
  • Three of the 6 patients had palpable inguinal nodes, of whom 2 died after chemotherapy for unresectable disease and 1 died of other causes 51 months after negative BILND.
  • In patients with scrotal melanoma the 5-year actuarial disease specific and recurrence-free survival rates were 33.3% and 33.3%, respectively, at a median followup of 36 months.
  • CONCLUSIONS: Partial penectomy or WLE provided effective local control for low stage penile or urethral melanomas and all scrotal lesions.
  • Patients showing clinically positive, proven metastasis died despite appropriate surgical procedures and multi-agent chemotherapy.
  • Prophylactic modified inguinal lymphadenectomy should be considered in select patients with penile, scrotal and anterior urethral melanoma.
  • [MeSH-major] Genital Neoplasms, Male / surgery. Melanoma / surgery. Penile Neoplasms / surgery. Scrotum / surgery. Urethral Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease Progression. Disease-Free Survival. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Retrospective Studies. Survival Rate

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  • [CommentIn] J Urol. 2006 Apr;175(4):1574-5; author reply 1575-6 [16516049.001]
  • (PMID = 15879790.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Black PC, Lange PH, Takayama TK: Extensive palliative surgery for advanced mesothelioma of the tunica vaginalis. Urology; 2003 Oct;62(4):748
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  • Malignant mesothelioma of the tunica vaginalis is a rare tumor managed principally by radical surgical resection.
  • Chemotherapy and radiotherapy have limited efficacy.
  • We report on a 67-year-old man with severe debilitation from multiple scrotal and inguinal recurrences of a malignant mesothelioma originating in the right tunica vaginalis.
  • Local pain from extensive tumor spread prevented ambulation.
  • Aggressive surgical debridement (total penectomy and scrotectomy) and perineal urethrostomy afforded the patient significant improvement in his quality of life before he finally died of the disease 3 years after diagnosis.
  • [MeSH-major] Deoxycytidine / analogs & derivatives. Mesothelioma / surgery. Palliative Care. Testicular Neoplasms / surgery
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Combined Modality Therapy. Debridement. Fatal Outcome. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Penis / surgery. Scrotum / surgery. Urethra / surgery

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  • (PMID = 14550461.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
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8. Shah BK, Qamruzzaman Y, Serban K, Hire E, Ying SC: First case report of locally advanced malignant nodular hidradenoma of the scrotum. Onkologie; 2010;33(12):701-3

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  • [Title] First case report of locally advanced malignant nodular hidradenoma of the scrotum.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant tumor of the eccrine glands, and most commonly involves the head, trunk, and extremities.
  • To the best of our knowledge, MNH of the scrotum has not yet been described in the English literature.
  • Despite the use of surgery, chemotherapy, radiotherapy, and hormonal therapy, optimal treatment of MNH is unclear.
  • CASE REPORT: We describe the case of a 30-year-old African American man who was diagnosed with locally advanced MNH of the scrotum and treated with surgery.
  • CONCLUSIONS: This is the first case report of MNH of the scrotum.
  • Surgery alone may be sufficient for the treatment of localized or locally advanced MNH.
  • [MeSH-major] Acrospiroma / pathology. Genital Neoplasms, Male / pathology. Scrotum / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Follow-Up Studies. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Male. Neoplasm Staging

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 21124043.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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9. Zouhair A, Weber D, Belkacémi Y, Ketterer N, Dietrich PY, Villà S, Scandolaro L, Bieri S, Studer G, Delacretaz F, Girardet C, Mirimanoff RO, Ozsahin M, Rare Cancer Network: Outcome and patterns of failure in testicular lymphoma: a multicenter Rare Cancer Network study. Int J Radiat Oncol Biol Phys; 2002 Mar 1;52(3):652-6
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  • PURPOSE: To assess the outcome and patterns of failure in patients with testicular lymphoma treated by chemotherapy (CT) and/or radiation therapy (RT).
  • Full staging workup (chest X-ray, testicular ultrasound, abdominal ultrasound, and/or thoracoabdominal computer tomography, bone marrow assessment, full blood count, lactate dehydrogenase, and cerebrospinal fluid evaluation) was completed in 18 (50%) patients.
  • External RT was delivered to scrotum alone (n = 12) or testicular, iliac, and para-aortic regions (n = 8).
  • The median RT dose was 31 Gy (range: 20-44 Gy) in a median of 17 fractions (10-24), using a median of 1.8 Gy (range: 1.5-2.5 Gy) per fraction.
  • In univariate analyses, statistically significant factors favorably influencing the outcome were early-stage and combined modality treatment.
  • Multivariate analysis revealed that the most favorable independent factors predicting the outcome were younger age, early-stage disease, and combined modality treatment.
  • [MeSH-major] Lymphoma, Non-Hodgkin / drug therapy. Lymphoma, Non-Hodgkin / radiotherapy. Testicular Neoplasms / drug therapy. Testicular Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Disease-Free Survival. Doxorubicin / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Orchiectomy. Prednisolone / administration & dosage. Prognosis. Radiotherapy Dosage. Recurrence. Retrospective Studies. Treatment Failure. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 11849786.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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10. Planelles Gómez J, Vergés Prósper A, Rubio Tortosa I, Beamud Cortés M, Pastor Navarro T, Beltrán Armada JR, San Juan de Laorden C: [Bilateral synchronic testicular tumor with germ cell intratubular neoplasia foci: case report]. Arch Esp Urol; 2007 Mar;60(2):205-7
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  • [Title] [Bilateral synchronic testicular tumor with germ cell intratubular neoplasia foci: case report].
  • [Transliterated title] Tumor testicular bilateral sincrónico con focos de neoplasia intratubular de células germinales: presentación de un caso.
  • OBJECTIVE: To report one case of bilateral synchronic testicular tumor with germ cell intratubular neoplasia foci affecting both testicles.
  • METHODS: We describe the case of a 29-year-old male presenting with a painless tumor in the left testicle for a month.
  • With the suspect of testicular tumor scrotal ultrasound, tumor markers and extension study to rule out metastasis were performed.
  • RESULTS: Ultrasound showed a hypertrophic left testicle with a lesion suspect for neoplasia, and incidental diagnosis of a hypoechoic lesion with augmented Doppler flow within the right testicle.
  • Bilateral orchyectomy was performed with the pathologic diagnosis of classic seminoma with germ cell intratubular neoplasia foci in both testicles.
  • Treatment was completed with two cycles of chemotherapy.
  • The most frequent histological type is classic seminoma.
  • The diagnosis and treatment are similar to unilateral testicular tumors except certain cases in which partial excision of the testicle may be considered.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Seminoma / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Atrophy. Carboplatin / administration & dosage. Combined Modality Therapy. Humans. Male. Orchiectomy. Remission Induction. Testis / pathology

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  • (PMID = 17484493.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin
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11. Enjoji M, Noguchi K, Watanabe H, Yoshida Y, Kotoh K, Nakashima M, Watanabe T, Nakamuta M, Nawata H: A novel tumour marker RCAS1 in a case of extramammary Paget's disease. Clin Exp Dermatol; 2003 Mar;28(2):211-3
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  • [Title] A novel tumour marker RCAS1 in a case of extramammary Paget's disease.
  • Hepatic arterial infusion chemotherapy was carried out and the tumours clearly reduced in size.
  • Serum levels of some common tumour markers were not elevated, even prior to therapy.
  • We measured serum levels of a novel tumour-associated antigen, RCAS1, because its expression was detected in the tumour cells.
  • The patient's serum RCAS1 level was elevated (22.0 U/mL) before therapy and fell during (10.5 U/mL) and after (5.0 U/mL) therapy.
  • Therefore, serum RCAS1 levels may be valuable as a potential biomarker for monitoring therapeutic efficacy against Paget's disease.
  • [MeSH-major] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Genital Neoplasms, Male / immunology. Liver Neoplasms / immunology. Paget Disease, Extramammary / immunology. Scrotum. Skin Neoplasms / immunology

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  • (PMID = 12653716.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / EBAG9 protein, human
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12. Kosan M, Gonulalan U, Ugurlu O, Seckin S, Adsan O: Embryonal paratesticular rhabdomyosarcoma: a case of young adult patient who has inguinal relapse. Int Urol Nephrol; 2007;39(4):1159-61
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  • Scrotal rhabdomyosarcomas originating from paratesticular tissue are most frequently seen in childhood and young adulthood.
  • We present a young male with inguinal relapse in the early period that we had achieved a good clinical outcome with chemotherapy and radiotherapy protocols.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Inguinal Canal / pathology. Rhabdomyosarcoma, Embryonal / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Fine-Needle. Combined Modality Therapy. Humans. Male. Neoplasm Recurrence, Local. Scrotum

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  • [Cites] J Clin Oncol. 2002 Jan 15;20(2):449-55 [11786573.001]
  • [Cites] Br J Urol. 1991 Oct;68(4):418-20 [1933165.001]
  • [Cites] J Urol. 1998 Mar;159(3):1031-4 [9474226.001]
  • (PMID = 17310317.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Michael H, Lucia J, Foster RS, Ulbright TM: The pathology of late recurrence of testicular germ cell tumors. Am J Surg Pathol; 2000 Feb;24(2):257-73
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  • A total of 91 men had histologically documented late recurrences of testicular germ cell tumors characterized by a complete response to treatment with a subsequent disease-free interval of at least 2 years and no evidence of a second primary lesion.
  • Ninety percent of the patients for whom information was available received chemotherapy shortly after their initial diagnosis of testicular germ cell tumors; most of the other patients were known to have stage I disease initially.
  • Thus, teratoma was the most common type of neoplasm in late recurrences.
  • Excluding teratoma coexisting with other types of neoplasms, yolk sac tumor was the most frequent type of tumor in patients with late recurrence.
  • It occurred in 47% of patients, either alone or with teratoma, another nonteratomatous germ cell tumor type, or a "nongerm cell malignant tumor."
  • Unusual types of yolk sac tumor, including glandular, parietal, clear cell, and pleomorphic patterns, were seen frequently in late recurrences and often raised differential diagnostic problems with "nongerm cell" carcinomas.
  • A smaller number of late recurrences consisted of other types of neoplasms.
  • Twenty percent of patients with late recurrence had a nonteratomatous germ cell tumor other than yolk sac tumor, either alone, with yolk sac tumor, or with a "nongerm cell malignant tumor."
  • Most of these nonteratomatous germ cell tumors other than yolk sac tumor were embryonal carcinoma, although rarely seminoma and choriocarcinoma were encountered.
  • "Nongerm cell malignant tumors," including both sarcomas and carcinomas of various types, occurred in 23% of late-recurrence patients, either alone or with a nonteratomatous germ cell tumor.
  • Late recurrences were seen in many different sites in these patients, including the retroperitoneum, abdomen, pelvis, liver, mediastinum, lung, bone (femur, vertebra, and rib), lymph nodes outside the retroperitoneum and mediastinum (supraclavicular, neck, and axillary regions), scrotum and inguinal regions, adrenal gland, chest wall, and buttocks.
  • Patients whose late recurrences consisted of pure "nongerm cell malignant tumor" or pure germ cell tumor (yolk sac tumor or other types) had a much worse prognosis: Only 36% to 37% were alive with no evidence of disease.
  • Patients with two different types of nonteratomatous malignancies in their late recurrences had a dismal clinical course: Only 17% with both yolk sac tumor and other nonteratomatous germ cell tumor had no evidence of disease, whereas no patient with both nonteratomatous germ cell tumor and "nongerm cell malignant tumor" was disease free.
  • Furthermore, late recurrence is not likely to respond to chemotherapy and is best treated by surgical excision when possible.
  • [MeSH-major] Germinoma / pathology. Neoplasm Recurrence, Local / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Embryonal / complications. Carcinoma, Embryonal / pathology. Carcinoma, Embryonal / therapy. Choriocarcinoma / complications. Choriocarcinoma / pathology. Choriocarcinoma / therapy. Endodermal Sinus Tumor / complications. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / therapy. Fluorescent Antibody Technique, Direct. Humans. Male. Neoplasm Staging. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / therapy. Sarcoma / complications. Sarcoma / pathology. Sarcoma / therapy. Seminoma / complications. Seminoma / pathology. Seminoma / therapy. Teratoma / complications. Teratoma / pathology. Teratoma / therapy

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  • (PMID = 10680894.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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14. Aki FT, Bilen CY, Tekin MI, Ozen H: Is scrotal violation per se a risk factor for local relapse and metastases in stage I nonseminomatous testicular cancer? Urology; 2000 Sep 1;56(3):459-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is scrotal violation per se a risk factor for local relapse and metastases in stage I nonseminomatous testicular cancer?
  • OBJECTIVES: To determine the risk of local recurrence and relapse in patients with Stage I nonseminomatous testicular cancer with scrotal violation.
  • RESULTS: Of 75 patients with Stage I nonseminomatous testicular cancer, 13 had scrotal violation.
  • The surgical margins and the spermatic cords were free of tumor in all patients.
  • Five patients (38%) in the scrotal violation group and 17 patients (27%) in the inguinal orchiectomy group experienced relapses.
  • All relapses, except one in the standard inguinal orchiectomy group, were treated successfully with chemotherapy and postchemotherapy surgery, if needed.
  • CONCLUSIONS: Scrotal violation without positive surgical margins and tumor spillage does not adversely affect relapse rate and survival.
  • Therefore, scrotal violation per se is not an exclusion criterion for the surveillance-only policy in patients with Stage I nonseminomatous testicular germ cell cancer.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / surgery. Scrotum / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Follow-Up Studies. Humans. Inguinal Canal / surgery. Male. Middle Aged. Neoplasm Recurrence, Local / etiology. Orchiectomy / adverse effects. Orchiectomy / methods. Orchiectomy / mortality. Retrospective Studies. Risk Factors. Survival Rate

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  • (PMID = 10962315.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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15. Gupta P, Singh U, Singh SK, Kapoor R, Gupta V, Das A: Bilateral symmetrical metastasis to all extraocular muscles from distant rhabdomyosarcoma. Orbit; 2010 Jun;29(3):146-8
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  • CASE REPORT: A 14-year-old male patient presented with inguinal mass involving the scrotum.
  • After 2 weeks of initial surgery the patient developed bilateral axial proptosis and radiological imaging revealed bilateral extraocular muscle thickening involving all the extraocular muscles.
  • The present report describes one such patient with favorable initial response to chemotherapy and muscle thickness reverting to normal.
  • Metastasis from a distant site should be considered in differential diagnosis when evaluating a patient with bilateral enlargement of all extraocular muscles.
  • [MeSH-major] Muscle Neoplasms / secondary. Rhabdomyosarcoma / secondary. Scrotum / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease Progression. Follow-Up Studies. Humans. Male. Neoplasm Invasiveness / pathology. Neoplasm Staging. Oculomotor Muscles. Orbital Neoplasms / drug therapy. Orbital Neoplasms / secondary. Orchiectomy / methods. Risk Assessment

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  • (PMID = 20497080.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Shimamoto K, Tanji N, Ozaw A, Sasaki T, Ikeda T, Iseda T, Yokoyama M: [Intrascrotal rhabdomyosarcoma in adult: a case report]. Nihon Hinyokika Gakkai Zasshi; 2009 May;100(4):545-9

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  • The patient was a 34-year-old man presenting with the right intra-scrotal painless mass.
  • With a diagnosis of right intrascrotal tumor, the patient underwent right high orchiectomy.
  • The pathological diagnosis of pleomorphic rhabdomyosarcoma arisen from the right spermatic cord was made.
  • Computed tomography revealed a single metastasis in the para-vena cava lymph node.
  • Systemic chemotherapy with vincristine, actinomycin D, plus cyclophosphamide (VAC therapy), and etoposide plus cisplatin (EP therapy) were made according to Intergroup Rhabdomyosarcoma Study (IRS)-IV Regimen 45.
  • But the chemotherapy was ineffective and a retoroperitoneal lymphadenectomy (RPLND) was therefore performed.
  • After 3 months following RPLND, the tumor relapsed in a pelvic lymph node involved in right ureter and ileocaecal valve.
  • Resection of the tumor with ileocaecum was performed and then intraoperative radiotherapy (15 Gy) against the tumor bed was performed to ensure the curative effects.
  • After his recovery, he received a total of 6 courses of systemic chemotherapy consisting of vincristin, ifosphamide, etoposide (IRS-IV Regimen 47).
  • The patient was rigorously followed up for 42 months after the final chemotherapy, with no tumor recurrence.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Genital Neoplasms, Male / therapy. Lymph Node Excision. Orchiectomy. Radiotherapy, Adjuvant. Rhabdomyosarcoma / therapy. Scrotum
  • [MeSH-minor] Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local / therapy. Treatment Outcome

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  • (PMID = 19514277.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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17. Zhu Y, Ye DW, Yao XD, Zhang SL, Dai B, Zhang HL, Shen YJ, Mao HR: Clinicopathological characteristics, management and outcome of metastatic penoscrotal extramammary Paget's disease. Br J Dermatol; 2009 Sep;161(3):577-82
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  • All the 10 patients received 5-fluorouracil- or docetaxel-based chemotherapy.
  • In three patients, (18)F-fluorodeoxyglucose positron emission tomography (PET)-computed tomography (CT) scans revealed occult lymph node metastases which were overlooked at conventional CT examinations.
  • Two patients had complete response to the chemotherapy, three had partial response and five had progressive disease.
  • 5-Fluorouracil- or docetaxel based-chemotherapy was effective in some patients.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Paget Disease, Extramammary / pathology. Penile Neoplasms / pathology. Scrotum / pathology
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Cadherins / analysis. Female. Fluorouracil / therapeutic use. Humans. Male. Middle Aged. Neoplasm Invasiveness. Survival Analysis. Taxoids / therapeutic use

  • Hazardous Substances Data Bank. DOCETAXEL .
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  • (PMID = 19438449.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Taxoids; 15H5577CQD / docetaxel; U3P01618RT / Fluorouracil
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18. Mistrangelo M, Mobiglia A, Cassoni P, Castellano I, Maass J, Martina MC, Bellò M, Mussa A: [Verrucous carcinoma of the anus or Buschke-Lowenstein tumor of the anus: staging and treatment. Report of 3 cases]. Suppl Tumori; 2005 May-Jun;4(3):S29-30
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  • [Title] [Verrucous carcinoma of the anus or Buschke-Lowenstein tumor of the anus: staging and treatment. Report of 3 cases].
  • INTRODUCTION: Giant condyloma acuminatum or Buschke Lowenstein tumor of the anorectal and perianal regions is an uncommon entity that commonly affects genitalia.
  • MATERIALS AND METHODS: At the Oncological Surgical Department, University of Turin, three patients were diagnosed with a Buschke Lowenstein tumor.
  • In two cases immunodeficiency was evidentiated (HIV in one case and ciclosporin treatment in the second one).
  • The lesions were up to 15 cm of diameter and in one case scrotum was invaded.
  • All patients were submitted to extensive local surgical treatment.
  • All inguinal nodes revealed negative to definitive histological exam, that confirmed the diagnosis of Buschke Lowenstein tumor of the primary lesion.
  • Local surgery with elettrocautery or laser is the first treatment of choice, even if abdominoperineal amputation sec.
  • Others treatments proposed are radiotherapy, chemotherapy, interferon, iniquimod and so on.
  • Other studies are requested to value the best treatment.
  • [MeSH-major] Anus Neoplasms / pathology. Anus Neoplasms / surgery. Carcinoma, Verrucous / pathology. Carcinoma, Verrucous / surgery
  • [MeSH-minor] Adult. Humans. Male. Neoplasm Staging

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  • (PMID = 16437884.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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19. Zhang N, Gong K, Yang Y, Na YQ: [Treatment and prognosis of scrotal extramammary Paget's disease: a report of 23 cases]. Zhonghua Nan Ke Xue; 2006 Dec;12(12):1102-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Treatment and prognosis of scrotal extramammary Paget's disease: a report of 23 cases].
  • OBJECTIVE: To evaluate the clinical manifestation, management and prognostic characteristics of scrotal extramammary Pagets disease (EMPD).
  • METHODS: Twenty-three cases of EMPD were identified and retrospectively reviewed, and the clinical findings, surgical treatment, pathologic features and prognostic characteristics were evaluated.
  • Twenty of the patients underwent operations, 2 received radiotherapy and 1 chemotherapy.
  • RESULTS: Twenty-two patients of the total number were followed up for 7 to 223 months, averaging at 119, therapy and 1 chemotherapy. of whom 12 remained cancer free, 1 died of tumor, 3 died of intercurrent disease, 4 experienced local recurrence, 1 relapsed with inguinal lymph node metastasis and 1 developed inguinal lymph node metastasis exclusively.
  • CONCLUSION: The primary treatment of choice for scrotal EMPD is radical excision.
  • Scrotal EMPD tends to occur as a slowly growing lesion, mainly in the elderly, and has a good prognosis in cases of non-invasion.
  • [MeSH-major] Genital Neoplasms, Male / therapy. Paget Disease, Extramammary / therapy. Scrotum
  • [MeSH-minor] Aged. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 17201257.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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20. May M, Seehafer M, Helke C, Gunia S, Hoschke B: [Liposarcoma of the spermatic cord--report of one new case and review of the literature]. Aktuelle Urol; 2004 Apr;35(2):130-3
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  • [Transliterated title] Liposarkom des Samenstrangs--Darstellung eines Falls.
  • Preferential treatment of spermatic cord liposarcoma is radical orchiectomy with high ligation of the cord.
  • Radiation therapy is recommended in addition to surgery in cases with evidence of more aggressive tumour behavior (i.e., high-grade tumour, lymphatic invasion, inadequate margin, or recurrence).
  • A 39-year-old-male presented with a 4-year history of a mass in the left scrotum.
  • Pathological analysis demonstrated a well-differentiated liposarcoma with tumour detection in the surgical margin.
  • In view of the incomplete surgical removal of the tumour a retroperitoneal reoperation of the testicular vessels and vas deferent with R0-resection was conducted.
  • Without any postoperative adjuvant therapy in evidence of recurrence or metastasis was noted during the 12-month follow-up period.
  • Radical orchiectomy with wide local excision of the mass is the recommended therapy, while adjuvant radiotherapy may be considered in high-grade tumours and in recurrent liposarcomas.
  • Retroperitoneal lymphadenectomy does not offer any additional therapeutic benefit, and the role of chemotherapy is not well defined.
  • Regardless of initial therapy, the risk of local recurrence always necessitates long-term followup.
  • [MeSH-major] Genital Neoplasms, Male. Liposarcoma. Spermatic Cord
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local. Orchiectomy. Radiotherapy, Adjuvant. Reoperation. Time Factors

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  • (PMID = 15146377.001).
  • [ISSN] 0001-7868
  • [Journal-full-title] Aktuelle Urologie
  • [ISO-abbreviation] Aktuelle Urol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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21. Avilés A, Neri N, Huerta-Guzmán J, Pérez F, Fernández R: Testicular lymphoma: organ-specific treatment did not improve outcome. Oncology; 2004;67(3-4):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular lymphoma: organ-specific treatment did not improve outcome.
  • OBJECTIVES: To assess whether the use of an organ-specific treatment could improve event-free survival (EFS) and overall survival as endpoints in testicular lymphoma in the early stage: IE and IIE.
  • METHODS: Thirty-four patients were selected to be treated with orchiectomy following six cycles of anthracycline-based combined chemotherapy and radiotherapy (scrotum and contralateral testis in stage IE, contralateral testis and lymph nodes in stage IIE).
  • Thus, actuarial curves at 5 years were 32% for EFS and 30% for overall survival, because all patients with failure and relapse died of tumor progression.
  • CONCLUSIONS: Testicular lymphomas remain a problem as regards defining the optimal treatment.
  • The use of a specific treatment based on organ-involved sites did not show any improvement in outcome.
  • It is evident that more specific therapies need to be explored.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, B-Cell / therapy. Orchiectomy. Testicular Neoplasms / therapy
  • [MeSH-minor] Actuarial Analysis. Aged. Anthracyclines / administration & dosage. Chemotherapy, Adjuvant. Disease-Free Survival. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Radiotherapy, Adjuvant. Survival Analysis. Treatment Outcome

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  • (PMID = 15557780.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anthracyclines
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22. Köksal Y, Yalçin B, Uner A, Akyüz C, Han U, Büyükpamukçu M: Primary testicular Burkitt lymphoma in a child. Pediatr Hematol Oncol; 2005 Dec;22(8):705-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 13-year-old boy was referred to the authors' hospital following a right inguinal orchiectomy for a right scrotal mass.
  • The left testis was found to be small with heterogeneous parenchyma by scrotal ultrasound (US) and other systemic investigations were negative for lymphoma involvement.
  • Considering stage I Burkitt lymphoma, chemotherapy was started.
  • The left testis was considered to be involved by lymphoma at initial diagnosis and chemotherapy was intensified.
  • At the end of 5 months of chemotherapy the left testis was again heterogeneous in US.
  • The patient is under regular follow-up and is in complete remission 19 months after the end of chemotherapy.
  • [MeSH-major] Burkitt Lymphoma. Scrotum / ultrasonography. Testicular Neoplasms
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Follow-Up Studies. Humans. Male. Neoplasm Staging. Remission Induction. Treatment Outcome

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  • (PMID = 16251177.001).
  • [ISSN] 0888-0018
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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23. Montgomery E, Fisher C: Paratesticular liposarcoma: a clinicopathologic study. Am J Surg Pathol; 2003 Jan;27(1):40-7
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  • One patient with WDL received radiation after his second recurrence and the myxoid/round cell liposarcoma received radiation and chemotherapy.
  • Only one example of DDL recurred, at 30 months; another patient, who refused therapy for 15 years, had a primary tumor 30 cm in diameter, displayed pulmonary metastases 1 month after excision, and died after 14 months.
  • One DDL recurred and only one of five (20%) developed metastases, but the mean follow-up for DDL was only 24 months.
  • [MeSH-major] Liposarcoma / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Retrospective Studies. Scrotum / pathology. Spermatic Cord / pathology. Testis / pathology

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  • (PMID = 12502926.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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