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Items 1 to 31 of about 31
1. Su O, Onsun N, Demirkesen C, Aydin Y, Pirmit S, Gereli M: A case of CD4+/CD56+ hematodermic neoplasm (plasmacytoid dendritic cell neoplasm). Dermatol Online J; 2010;16(4):8
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  • [Title] A case of CD4+/CD56+ hematodermic neoplasm (plasmacytoid dendritic cell neoplasm).
  • CD4+/CD56+ hematodermic neoplasm (blastic plasmacytoid dendritic cell neoplasm) involving the skin is relatively rare and has been of significant interest in the recent literature.
  • Histological examination of skin biopsies showed an intense hematolymphoid infiltration in the dermis and in the subcutaneous tissue.
  • In situ hybridization (ISH) for Epstein-Barr virus was negative and the diagnosis was blastic NK cell lymphoma.
  • The patient was treated with a hyper-CVAD regimen (cyclophosphamide, vincristine, doxorubicine, dexamethasone, methotrexate, and cytarabine).This treatment regimen achieved partial remission but the patient died eight months after the diagnosis.
  • The patient presented with exclusively cutaneous involvement at the beginning but progressed rapidly and died shortly after despite aggressive chemotherapy.
  • Due to its rarity, we present here a case of CD4+/CD56+ hematodermic neoplasm.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. DNA Nucleotidylexotransferase / analysis. Dendritic Cells / immunology. Dendritic Cells / pathology. Dexamethasone / therapeutic use. Doxorubicin / therapeutic use. Fatal Outcome. Humans. Male. Middle Aged. Vincristine / therapeutic use

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  • (PMID = 20409415.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD4; 0 / Antigens, CD56; 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; EC 2.7.7.31 / DNA Nucleotidylexotransferase; CVAD protocol
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2. Garg PK, Khurana N, Hadke NS: Subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma. Hepatobiliary Pancreat Dis Int; 2009 Apr;8(2):209-11
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  • [Title] Subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma.
  • Gallbladder carcinoma metastasizing to breast and subcutaneous tissue is not known.
  • METHOD: This report describes an interesting and unusual case of asymptomatic gallbladder carcinoma presenting with subcutaneous and breast metastasis.
  • RESULTS: A 42-year-old woman presented with multiple subcutaneous nodules over the abdominal wall, anterior chest wall, back and in bilateral breasts.
  • The patient was investigated for a primary neoplasm.
  • She was diagnosed as a case of metastatic adenocarcinoma of the gallbladder and palliative combination chemotherapy with gemcitabine and carboplatin was given.
  • But she developed jaundice and deteriorated dramatically in a short span of time.
  • No specific therapy could be started and she was given supportive treatment.
  • She died within three weeks of diagnosis due to hepatic encephalopathy.
  • CONCLUSIONS: This report highlights an unusual metastasis of gallbladder carcinoma to the breast and subcutaneous tissue presenting as multiple lesions, which has never been reported in the English literature.

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  • (PMID = 19357037.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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3. Angeloni M, Muratori F, Magarelli N, Chalidis BE, Ricci R, Rossi B, Maccauro G: Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report. Int Semin Surg Oncol; 2008;5:11

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  • [Title] Exophytic growth of a neglected giant subcutaneous Leiomyosarcoma of the lower extremity. A case report.
  • BACKGROUND: Superficial leiomyosarcoma is an exceedingly uncommon malignant tumor which could be located either to cutaneous or subcutaneous tissues.
  • Magnetic Resonance Imaging revealed a soft-tissue mass which was well defined from the surrounding bone and muscles.
  • As initial biopsy in another hospital hadn't clarified the true nature of the lesion, new samples were taken and the diagnosis of leiomyosarcoma was established.
  • Laboratory examination showed no distant metastasis and wide excision of the neoplasm was decided.
  • After tumor resection, the remaining soft tissue and skin defect was covered with a gastrocnemius myocutaneous flap.
  • The postoperative period was uneventful and wound healing was followed by local radiotherapy and systemic chemotherapy.
  • CONCLUSION: Proper surgical management of soft tissue leiomyosarcoma continues to remain the cornerstone of treatment efficacy and the most important prognostic factor for patients' survival.
  • Reconstruction of the remaining soft tissue defect should be always performed at the same operative time when removal of giant size tumors leaves an uncovered cavity with an inadequate sleeve of muscular and skin tissues.

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  • (PMID = 18495007.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2409359
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4. Strecker EP, Heber R, Boos I, Göttmann D, Heinrich D: Preliminary experience with locoregional intraarterial chemotherapy of uterine cervical or endometrial cancer using the peripheral implantable port system (PIPS): a feasibility study. Cardiovasc Intervent Radiol; 2003 Mar-Apr;26(2):118-22
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  • [Title] Preliminary experience with locoregional intraarterial chemotherapy of uterine cervical or endometrial cancer using the peripheral implantable port system (PIPS): a feasibility study.
  • The purpose of this study was to assess the suitability of a percutaneously implantable catheter port system (PIPS) for repeated intraarterial locoregional chemotherapy (ILC) for cervical and endometrial carcinoma.
  • Chemotherapy was performed adjuvantly after surgery (n = 14) or neo-adjuvantly to enable surgery, or for palliation (n = 16).
  • Complications included catheter dislocation (n = 1), catheter thrombosis (n = 2), subcutaneous infection (n = 1), port-bed skin atrophy (n = 1), requiring port explantation in 3 patients.
  • At 2 years follow-up, complete remission was observed in 7/14 patients with adjuvant chemotherapy, partial remission in 3/14.
  • Successful down-staging could be achieved in 4/8 patients with neo-adjuvant chemotherapy.
  • The PIPS is suitable for repeated ILC which may be a valuable method for pre- and post-surgical therapy of advanced or high-risk cervical and endometrial cancer, for adjuvant chemotherapy as well as neo-adjuvantly for down-staging, or for palliation.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Endometrial Neoplasms / therapy. Infusion Pumps, Implantable. Uterine Cervical Neoplasms / therapy. Uterine Neoplasms / therapy
  • [MeSH-minor] Adult. Aorta, Abdominal / radiography. Aorta, Abdominal / surgery. Catheters, Indwelling / adverse effects. Disease Progression. Equipment Design. Equipment Safety. Feasibility Studies. Female. Femoral Artery / radiography. Femoral Artery / surgery. Fibrinolytic Agents / therapeutic use. Follow-Up Studies. Humans. Iliac Artery / radiography. Iliac Artery / surgery. Infusions, Intra-Arterial / instrumentation. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / therapy. Postoperative Complications / etiology. Postoperative Complications / mortality. Survival Analysis. Thrombosis / drug therapy. Thrombosis / etiology. Time Factors. Tissue Plasminogen Activator / therapeutic use. Treatment Outcome. Vascular Surgical Procedures. Women's Health


5. Nizza D, Simoneaux SF: Blastic plasmacytoid dendritic cell neoplasm presenting as a subcutaneous mass in an 8-year-old boy. Pediatr Radiol; 2010 Dec;40 Suppl 1:S40-2
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  • [Title] Blastic plasmacytoid dendritic cell neoplasm presenting as a subcutaneous mass in an 8-year-old boy.
  • Blastic plasmacytoid dendritic cell neoplasm (also referred to as CD4+/CD56+ hematodermic neoplasm) is a rare hematological malignancy typically seen in older adults.
  • The disease presents with nonspecific cutaneous lesions and advances toward a fatal leukemic phase despite an often favorable initial response to chemotherapy.
  • We report a case of histopathologically proven blastic plasmacytoid dendritic cell neoplasm arising in an otherwise healthy and asymptomatic 8-year-old boy who noticed a painless mass within the subcutaneous tissues below the left calf.
  • [MeSH-major] Dendritic Cells / diagnostic imaging. Dendritic Cells / pathology. Diagnostic Imaging / methods. Plasmacytoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Leg / diagnostic imaging. Leg / pathology. Male. Radionuclide Imaging

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  • (PMID = 20552185.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Zhang HY, Liu AL, Zhou LS, He MX, Wang JX: Primary cutaneous marginal zone B-cell lymphoma with amyloid deposition: report of two cases with review of literature. Chin J Cancer; 2010 Jun;29(6):634-40
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  • If there was a great amount of amyloid depositions in the skin tissue, it would be considered to be amyloid deposition disease at first, and then primary cutaneous marginal zone B-cell lymphoma (PCMZL).
  • This study was to analyze the diagnosis and differential diagnosis of two cases of PCMZL with amyloid deposition.
  • RESULTS: Case 1, a 71-year-old Chinese male, had a subcutaneous mass on the right elbow that was initially diagnosed with "amyloidosis" in 2004.
  • Three years after the initial diagnosis, he developed recurrences on the right para-auxillary that was still diagnosed with "probably amyloidosis".
  • Four years after the first diagnosis, the patient presented a lesion on the right para-auxillary with a diameter of 2 cm and a lesion on the temporal-parietal dural with a size of 6.0 cmx3.0 cmx3.0 cm.
  • Case 2, a 68-year-old Chinese male, had a subcutaneous mass next to back of the left ear with a size of 9.0 cmx5.0 cm, and he underwent a operation one year previously because of subcutaneous mass in the same site.
  • Microscopically, the tumors of both cases were located in dermis and subcutaneous, tumor cells were medium size with a nodular or diffuse distribution, and some of tumor cells were plasmacytoid/plasma cells.
  • Morphologically, the temporal-parietal dural lesion was similar to subcutaneous lesion and infiltrated into cranial (case 1).
  • Congo red staining showed positive of amyloid deposition in tumor tissues of both cases.
  • CONCLUSIONS: Our findings suggest that amyloid deposition rarely present in both primary and metastatic tumors in PCMZL, and its diagnosis should be considered to avoid misdiagnosis.
  • The patients with PCMZL should undergo regular examinations and chemotherapy as well as a long-term follow-up since it is apt to recur or relapse.
  • [MeSH-minor] Aged. Antigens, CD / metabolism. Antigens, CD45 / metabolism. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Elbow. Follow-Up Studies. Humans. Interferon Regulatory Factors / metabolism. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Prednisone / therapeutic use. Vincristine / therapeutic use

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  • (PMID = 20507739.001).
  • [ISSN] 1000-467X
  • [Journal-full-title] Chinese journal of cancer
  • [ISO-abbreviation] Chin J Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Interferon Regulatory Factors; 0 / interferon regulatory factor-4; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; EC 3.1.3.48 / Antigens, CD45; VB0R961HZT / Prednisone; CHOP protocol
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7. Tanaka H, Sasayama T, Nishihara M, Arai A, Kawamura A, Kanomata N, Itoh T, Kohmura E: Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report. Neurol Med Chir (Tokyo); 2010;50(8):689-93
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  • [Title] Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report.
  • Magnetic resonance (MR) imaging demonstrated multiple tumors in the brain, subcutaneous soft tissue, and mediastinum.
  • The patient underwent surgery, followed by chemotherapy and radiotherapy.
  • The histological diagnosis was undifferentiated high-grade sarcoma.
  • The patient underwent high-dose methotrexate therapy, but showed no response.
  • Promoter hypermethylation in the O(6)-methylguanine-deoxyribonucleic acid methyltransferase (MGMT) genes was detected and MGMT protein expression was negative in the recurrent tumor, so temozolomide (TMZ) salvage chemotherapy was given, and follow-up MR imaging showed tumor reduction.
  • [MeSH-major] Antineoplastic Agents, Alkylating / therapeutic use. Brain Neoplasms / therapy. Dacarbazine / analogs & derivatives. Neoplasm Recurrence, Local / therapy. Sarcoma / therapy
  • [MeSH-minor] Adult. Combined Modality Therapy. DNA Modification Methylases / genetics. DNA Modification Methylases / metabolism. DNA Repair Enzymes / genetics. DNA Repair Enzymes / metabolism. Female. Gene Silencing. Humans. Salvage Therapy. Soft Tissue Neoplasms / enzymology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / therapy. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism

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  • (PMID = 20805657.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Tumor Suppressor Proteins; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
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8. Le QT, Koong A, Lieskovsky YY, Narasimhan B, Graves E, Pinto H, Brown JM, Spielman D: In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys; 2008 Jul 15;71(4):1151-7
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  • METHODS AND MATERIALS: Volume-localized lactate-edited (1)H magnetic resonance spectroscopy at 1.5 T was performed in vivo on involved neck nodes and control subcutaneous tissues in 36 patients with Stage IV head and neck cancer.
  • Patients were treated with either two cycles of induction chemotherapy (tirapazamine, cisplatin, 5-fluorouracil) followed by simultaneous chemoradiotherapy or the same regimen without tirapazamine.
  • RESULTS: The lactate SI was greater for the involved nodes (median, 0.25) than for the subcutaneous tissue (median, 0.04; p = 0.07).
  • CONCLUSIONS: The lactate SI did not correlate with tumor pO(2), treatment response, or locoregional control.

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  • (PMID = 18258377.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA118582-03; United States / NCI NIH HHS / CA / P01 CA067166; United States / NCI NIH HHS / CA / P01 CA067166-120013; United States / NCI NIH HHS / CA / CA118582-03; United States / NCI NIH HHS / CA / CA-67166; United States / NCI NIH HHS / CA / CA067166-120013; United States / NCI NIH HHS / CA / 1 R01 CA118582-01; United States / NCI NIH HHS / CA / R01 CA118582
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protons; 33X04XA5AT / Lactic Acid
  • [Other-IDs] NLM/ NIHMS56580; NLM/ PMC2601688
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9. Mukai HY, Okoshi Y, Shimizu S, Katsura Y, Takei N, Hasegawa Y, Kojima H, Mori N, Nagasawa T: Successful treatment of a patient with subcutaneous panniculitis-like T-cell lymphoma with high-dose chemotherapy and total body irradiation. Eur J Haematol; 2003 Jun;70(6):413-6
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  • [Title] Successful treatment of a patient with subcutaneous panniculitis-like T-cell lymphoma with high-dose chemotherapy and total body irradiation.
  • A 24-yr-old man was referred for fever, right cheek swelling, subcutaneous tumor and liver dysfunction.
  • Physical examination showed an elastic hard subcutaneous tumor on the right cheek, left axillary lymph node swelling and multiple small subcutaneous tumors in the trunk.
  • Biopsy of the subcutaneous tumor showed proliferation of medium-sized cells with abundant clear cytoplasm and hyperchromatic nuclei among the subcutaneous fat tissues.
  • He was thus diagnosed as having subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and treated with dose-escalated CHOP regimen.
  • After three courses of the chemotherapy, he was further treated with high-dose chemotherapy and total body irradiation (TBI) with autologous peripheral blood stem cell rescue.
  • We consider that SPTCL with hemophagocytosis is an extremely aggressive disease, and high-dose chemotherapy and TBI should be included for the choice of the treatment.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / diagnosis. Lymphoma, T-Cell, Peripheral / therapy. Panniculitis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow Examination. Humans. Magnetic Resonance Imaging. Male. Neoplasm, Residual / diagnosis. Peripheral Blood Stem Cell Transplantation. Remission Induction / methods. Subcutaneous Tissue / pathology. Whole-Body Irradiation


10. Patel T, Bansal R, Trivedi P, Modi L, Shah MJ: Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report. Indian J Pathol Microbiol; 2005 Oct;48(4):482-4
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  • [Title] Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report.
  • A 25 year old woman, who had undergone chemotherapy, partial excision of tumor followed by radiotherapy of sarcomatoid mesothelioma of the pleura, presented three months later with painless widespread subcutaneous nodules.
  • It is essential to differentiate neoplasm metastatic to the skin and subcutis from primary and benign lesions of the same region.
  • FNAC is accurate and efficient, in conjugation with clinical history, and it also prevents surgical biopsy in the diagnosis of metastatic subcutaneous lesion.
  • To our knowledge, this is the first case, reported till date, in which the sarcomatoid mesothelioma metastasized to the subcutaneous tissue and was diagnosed by fine needle aspiration cytology (FNAC).
  • [MeSH-major] Mesothelioma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Pleural Neoplasms. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary. Subcutaneous Tissue

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  • (PMID = 16366102.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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11. Huang GS, Chang WC, Lee HS, Taylor JA, Cheng TY, Chen CY: Merkel cell carcinoma arising from the subcutaneous fat of the arm with intact skin. Dermatol Surg; 2005 Jun;31(6):717-9
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  • [Title] Merkel cell carcinoma arising from the subcutaneous fat of the arm with intact skin.
  • BACKGROUND: Merkel cell carcinoma is a rare malignant neuroendocrine neoplasm characteristically arising from the dermis of sunlight-exposed skin.
  • OBJECTIVE: We present a patient with primary Merkel cell carcinoma arising from subcutaneous fat, with no involvement of the overlying skin.
  • METHODS: We report a 63-year-old woman with a primary lesion of Merkel cell carcinoma that arose from the subcutaneous fat layer of the left arm.
  • The lesion presented as a subcutaneous nodule with intact overlying skin.
  • MRI showed that the nodular lesion was located entirely in the subcutaneous fat layer, with no involvement of the dermis.
  • The patient received wide excision of the lesion with dissection of the regional lymph nodes and adjuvant radiotherapy and chemotherapy.
  • RESULTS: Histopathologic examination confirmed the diagnosis of Merkel cell carcinoma with local lymphatic metastasis, and the lesion was completely located in the subcutaneous fat, with no involvement of the dermis.
  • CONCLUSION: Primary Merkel cell carcinoma may arise from the subcutaneous fat and present as an entirely subcutaneous lesion with intact skin.
  • [MeSH-major] Carcinoma, Merkel Cell / diagnosis. Neoplasms, Adipose Tissue / surgery. Skin Neoplasms / diagnosis

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  • (PMID = 15996429.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Bouillot-Eimer S, Loiseau H, Vital A: Subcutaneous tumoral seeding from a glioblastoma following stereotactic biopsy: case report and review of the literature. Clin Neuropathol; 2005 Nov-Dec;24(6):247-51
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  • [Title] Subcutaneous tumoral seeding from a glioblastoma following stereotactic biopsy: case report and review of the literature.
  • Extracranial metastases from glioblastoma are uncommon, likely because short patient survival time prevent them to occur.
  • We describe a case of glioblastoma with concomitant seeding along the stereotactic biopsy trajectory and subcutaneous metastasis.
  • A computed tomographic-guided stereotactic biopsy was performed and microscopic examination attested a diagnosis of glioblastoma.
  • Radiotherapy and chemotherapy were administered.
  • Eight months later, the patient presented with a subcutaneous tumor in the left occipital region.
  • A cranial computed tomographic scan revealed a large enhancement of the initial tumor, intracranial tumor seeding along the stereotactic biopsy trajectory, and a subcutaneous tumor.
  • Partial resection of the subcutaneous lesion was performed, and histological examination identified an extracranial metastasis from the glioblastoma.
  • Although uncommon, this observation points to the risk of tumor seeding following stereotactic biopsy, and to the close connection between this intracranial seeding and subcutaneous metastasis.
  • [MeSH-major] Brain Neoplasms / pathology. Glioblastoma / secondary. Neoplasm Seeding. Soft Tissue Neoplasms / secondary. Stereotaxic Techniques / adverse effects. Subcutaneous Tissue / pathology

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  • (PMID = 16320817.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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13. Magro CM, Crowson AN, Kovatich AJ, Burns F: Lupus profundus, indeterminate lymphocytic lobular panniculitis and subcutaneous T-cell lymphoma: a spectrum of subcuticular T-cell lymphoid dyscrasia. J Cutan Pathol; 2001 May;28(5):235-47
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  • [Title] Lupus profundus, indeterminate lymphocytic lobular panniculitis and subcutaneous T-cell lymphoma: a spectrum of subcuticular T-cell lymphoid dyscrasia.
  • INTRODUCTION: The diagnosis and classification of lymphocytic lobular panniculitis (LLP) has historically proven to be a difficult challenge.
  • 2) an indeterminate group termed indeterminate lymphocytic lobular panniculitis (ILLP) (6 patients); and 3) subcutaneous T-cell lymphoma (SCTCL) (7 patients).
  • METHOD: Skin biopsy material was studied by conventional light microscopy, through immunophenotyping performed on sections from paraffin-embedded, formalin-fixed tissue and in some cases on sections of tissue frozen after receipt in physiological (Michel's) medium, and by polymerase chain reaction single-stranded conformational polymorphism analysis to assess for clonality of T-lymphocytes.
  • RESULTS: Patients with LEP had a prior diagnosis of LE or overlying skin changes which light microscopically were characteristic of LE.
  • Cytopenia was seen in 4 LEP patients; 1 also developed fever.
  • In LEP and ILLP, lesions resolved with hydroxychloroquine and/or steroid therapy, with recurrences following cessation of therapy.
  • In the SCTCL group 4 developed hemophagocytic syndrome, 4 died within 2 years of diagnosis, and 3 went into remission following chemotherapy.
  • Similar molecular and phenotypic features indicative of subcuticular lymphoid dyscrasia were encountered in cases of LEP and ILLP including a reduction in CD5, CD7, and/or monoclonal CD3 expression, a preponderance of CD8 lymphocytes within the subcutaneous fat and T-cell clonality.
  • Cases of phenotypically abnormal and/or clonal LEP showed one or more of local destruction, lesional size progression, fever, and cytopenias, but lesions responded to hydroxychloroquine and/or prednisone therapy and death attributable to panniculitis could not be documented.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD / analysis. Child. Child, Preschool. DNA, Neoplasm / analysis. Female. Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged. Polymerase Chain Reaction

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  • (PMID = 11401667.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / DNA, Neoplasm
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14. Benez A, Fierlbeck G, Lischka G: [Subcutaneous panniculitic T-cell lymphoma]. Hautarzt; 2000 Jul;51(7):513-6

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  • [Title] [Subcutaneous panniculitic T-cell lymphoma].
  • Subcutaneous panniculitic T-cell lymphoma is categorized as a subtype of peripheral T-cell lymphoma.
  • Patients typically present with nontender subcutaneous nodules.
  • We report a 75-year old patient with a three week history of asymptomatic subcutaneous nodules.
  • The diagnosis of subcutaneous T-cell lymphoma was confirmed by immunohistological and molecular biological studies.
  • Chemotherapy had to be interrupted due to a rapid worsening of the patient's general condition.
  • She died few weeks after confirmation of diagnosis.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / diagnosis. Panniculitis / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Disease Progression. Fatal Outcome. Female. Humans. Neoplasm Staging. Skin / pathology

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  • (PMID = 10969408.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] GERMANY
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15. Nuyten DS, van de Vijver MJ: Using microarray analysis as a prognostic and predictive tool in oncology: focus on breast cancer and normal tissue toxicity. Semin Radiat Oncol; 2008 Apr;18(2):105-14
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  • [Title] Using microarray analysis as a prognostic and predictive tool in oncology: focus on breast cancer and normal tissue toxicity.
  • Gene expression profiling is currently being used in many research projects aimed at identifying gene expression signatures in malignant tumors associated with prognosis and response to therapy.
  • An important goal of such research is to develop gene expression-based diagnostic tests that can be used to guide therapy in cancer patients.
  • Here we provide examples of studies using microarrays, especially focusing on breast cancer, in a wide range of fields including prediction of prognosis, distant metastasis and local recurrence, therapy response to radio- and chemotherapy, and normal tissue response.
  • [MeSH-major] Breast Neoplasms / diagnosis. Oligonucleotide Array Sequence Analysis / methods
  • [MeSH-minor] Female. Gene Expression / genetics. Gene Expression Profiling / instrumentation. Gene Expression Profiling / methods. Gene Expression Regulation, Neoplastic / genetics. Humans. Neoplasm Metastasis / genetics. Neoplasm Recurrence, Local / genetics. Predictive Value of Tests. Prognosis. Subcutaneous Tissue / pathology. Subcutaneous Tissue / radiation effects

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  • (PMID = 18314065.001).
  • [ISSN] 1532-9461
  • [Journal-full-title] Seminars in radiation oncology
  • [ISO-abbreviation] Semin Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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16. Dillman RO, Nanci AA, Williams ST, Kim RB, Hafer RL, Coleman CL, Wang PC, Duma CM, Chen PV, Selvan SR, Cornforth AN, DePriest C: Durable complete response of refractory, progressing metastatic melanoma after treatment with a patient-specific vaccine. Cancer Biother Radiopharm; 2010 Oct;25(5):553-7
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  • [Title] Durable complete response of refractory, progressing metastatic melanoma after treatment with a patient-specific vaccine.
  • A patient with metastatic melanoma who experienced a durable complete response after treatment with a patient-specific vaccine has been described in this article.
  • This 59-year-old woman presented with cervical spine metastases and, within the year, had experienced local disease progression and, despite various therapies, metastases to the axilla, rectum, gall bladder, and multiple soft-tissue sites.
  • She had previously received radiation therapy, combination chemotherapy, interleukin-2 plus interferon biotherapy, and gamma knife radiosurgery, and undergone multiple surgical resections.
  • At the time vaccine therapy was initiated, she had multiple, new, measurable, soft-tissue metastases that were increasing in size.
  • She was treated with a vaccine consisting of autologous dendritic cells incubated with irradiated tumor cells from an autologous tumor cell line and suspended in granulocyte-macrophage colony stimulating factor (GM-CSF), with subcutaneous injections once a week for 3 weeks and monthly for 5 months.
  • There was evidence of disease regression by the completion of therapy.
  • This is the first time she has been in a complete remission since her initial diagnosis.
  • Patient-specific vaccines can sometimes induce durable complete regression of progressing soft-tissue melanoma metastases.
  • [MeSH-major] Cancer Vaccines / therapeutic use. Melanoma / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Disease Progression. Disease-Free Survival. Female. Humans. Middle Aged. Neoplasm Metastasis. Remission Induction. Treatment Outcome

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  • (PMID = 20849310.001).
  • [ISSN] 1557-8852
  • [Journal-full-title] Cancer biotherapy & radiopharmaceuticals
  • [ISO-abbreviation] Cancer Biother. Radiopharm.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cancer Vaccines
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17. Al Ali J, Ko HH, Owen D, Steinbrecher UP: Epithelioid angiosarcoma of the small bowel. Gastrointest Endosc; 2006 Dec;64(6):1018-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Angiosarcoma is a rare soft-tissue neoplasm that occurs most often in the skin and the subcutaneous tissues but very rarely in the GI tract.
  • Enteroscopy revealed small ulcerated nodules in the distal duodenum and the proximal jejunum.
  • RESULTS: The intestinal nodules were treated with argon plasma coagulation, but the patient died 6 weeks after diagnosis.
  • CONCLUSIONS: The survival rate of intestinal angiosarcoma is poor, and most cases progress rapidly, with a 2-month median survival after diagnosis.
  • Further studies are needed to establish the role of adjuvant radiation or chemotherapy in the treatment of angiosarcoma.
  • [MeSH-minor] Aged, 80 and over. Biopsy. Diagnosis, Differential. Endoscopy, Gastrointestinal. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 17140922.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Kiyohara T, Kumakiri M, Kobayashi H, Shimizu T, Ohkawara A, Ohnuki M: A case of intravascular large B-cell lymphoma mimicking erythema nodosum: the importance of multiple skin biopsies. J Cutan Pathol; 2000 Sep;27(8):413-8
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  • The lesions were accompanied with hard, tender, intradermal or subcutaneous nodules mimicking erythema nodosum.
  • The second biopsy revealed emboli of atypical lymphocytes within many of the dilated and proliferated vessels in the deep dermis and subcutaneous tissue.
  • These findings confirmed the diagnosis of intravascular large B-cell lymphoma.
  • Before the treatment, the size of the nodules decreased spontaneously by about 50% in one month and significantly in two months.
  • Although combination chemotherapy, which consisted of CHOP, brought her partial remission, she experienced neurological symptoms 6 months after the initial treatment and died of brain metastasis 9 months after the treatment.
  • 1) the first biopsy revealed non-specific findings compatible with erythema nodosum; and 2) before the treatment, the nodules regressed spontaneously.
  • [MeSH-major] Erythema Nodosum / diagnosis. Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Neoplasm Regression, Spontaneous / pathology. Neoplasms, Vascular Tissue / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Humans. Middle Aged. Skin / blood supply. Skin / pathology

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  • (PMID = 10955689.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] DENMARK
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19. Stark AM, Buhl R, Hugo HH, Mehdorn HM: Malignant peripheral nerve sheath tumours--report of 8 cases and review of the literature. Acta Neurochir (Wien); 2001;143(4):357-63; discussion 363-4
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  • BACKGROUND: Though Malignant peripheral nerve sheath tumours (MPNST) are a rare entity accounting for 5-10% of soft-tissue sarcomas they are an important differential diagnosis to benign tumours of the peripheral nervous system regarding treatment and prognosis.
  • Two patients suffered from Neurofibromatosis type 1.
  • All of these developed local recurrence with a mean disease free survival time of 10.6 months.
  • During follow up, three patients developed distant metastases located in the lung, liver and subcutaneous tissue.
  • Five out of eight patients died during follow-up with a mean survival time of 11.6 months after diagnosis.
  • INTERPRETATION: MPNST is a rare and fatal diagnosis in neurosurgery with high risk of local recurrence and occurence of distant metastases.
  • Though mulitimodal therapy including surgical resection and adjuvant radiotherapy including brachytherapy is available, the prognosis remains dismal.
  • Modern clinical studies and the development of effective chemotherapy is needed in order to gain control of the disease.
  • [MeSH-major] Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / surgery. Neoplasm Recurrence, Local / mortality. Nerve Sheath Neoplasms / mortality. Nerve Sheath Neoplasms / surgery. Spinal Cord Neoplasms / mortality. Spinal Cord Neoplasms / surgery. Thoracic Neoplasms / mortality. Thoracic Neoplasms / surgery

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  • (PMID = 11437289.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 5
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20. Koscielny S: [The Merkel cell carcinoma]. Laryngorhinootologie; 2008 Mar;87(3):205-10; quiz 211
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  • The Merkel cell carcinoma is a rare tumor of the subdermal tissue.
  • Its origin are Merkel cells or the subcutaneous pluripotential stem cells.
  • Clinically, a subcutaneous rapidly growing tumor with or without enlarged lymph nodes is seen.
  • Surgical resection of the tumor combined with neck dissection followed by radiation therapy is the current therapy of choice.
  • Different chemotherapy protocols are available for patients with distant metastasis.
  • [MeSH-major] Carcinoma, Merkel Cell / diagnosis. Head and Neck Neoplasms / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Combined Modality Therapy. Humans. Lymphatic Metastasis. Neck Dissection. Neoplasm Staging. Radiotherapy, Adjuvant. Skin / pathology

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  • (PMID = 18322889.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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21. Kahwash SB, Qualman SJ: Cutaneous lymphoblastic lymphoma in children: report of six cases with precursor B-cell lineage. Pediatr Dev Pathol; 2002 Jan-Feb;5(1):45-53
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  • Three occurred in the scalp, one in the skin of the thigh, one in the skin of the face and breast, and one in the subcutaneous tissue of the orbit.
  • None of the cases had bone marrow involvement, while two had bone involvement (maxilla, distal tibia, and distal humerus in one case, and distal tibia and orbital bone in another case); only one case had lymphadenopathy (retroperitoneal).
  • The five patients who received multiagent chemotherapy are alive with follow-up intervals of 2 to 18 years.
  • Two patients had local recurrences and were given radiation therapy (one with repeating multiagent chemotherapy).
  • One patient (diagnosed in 1962) died of disseminated disease; she had been treated with radiation therapy and 6MP only.
  • Cutaneous B-LBL must be included in the differential diagnosis of small blue cell tumors, especially in children.
  • [MeSH-minor] Adolescent. Biomarkers, Tumor / analysis. Child. Child, Preschool. Combined Modality Therapy. Fatal Outcome. Female. Flow Cytometry. Humans. Immunohistochemistry. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local

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  • (PMID = 11815868.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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22. Lammers T, Kühnlein R, Kissel M, Subr V, Etrych T, Pola R, Pechar M, Ulbrich K, Storm G, Huber P, Peschke P: Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers. J Control Release; 2005 Dec 10;110(1):103-18
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  • Copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that are being broadly implemented in the delivery of anticancer therapeutics.
  • Upon radiolabeling, the copolymers were injected i.v., and their circulation kinetics, tissue distribution and tumor accumulation were monitored in rats bearing subcutaneous Dunning AT1 tumors.
  • It was found that increasing the average molecular weight of HPMA copolymers resulted in prolonged circulation times and in increased tumor concentrations.
  • Conjugation of carboxyl and hydrazide groups, as well as introduction of spacer, drug and peptide moieties reduced the long-circulating properties of the copolymers and as a result, lower levels were found in tumors and in all organs other than kidney.
  • Tumor-to-organ ratios were comparable to unmodified control for the majority of chemically modified copolymers, indicating that functionalization does not necessarily affect the tumor targeting ability of the copolymers and suggesting that HPMA copolymer-based drug delivery systems may prove to be attractive tools for more effectively treating various forms of advanced solid malignancy.
  • [MeSH-major] Antineoplastic Agents / pharmacokinetics. Drug Carriers / pharmacokinetics. Methacrylates / pharmacokinetics. Prostatic Neoplasms / metabolism
  • [MeSH-minor] Animals. Cell Line, Tumor. Doxorubicin / analogs & derivatives. Doxorubicin / chemical synthesis. Doxorubicin / pharmacokinetics. Male. Molecular Weight. Neoplasm Transplantation. Oligopeptides / chemistry. Oligopeptides / pharmacokinetics. Polymethacrylic Acids / chemical synthesis. Polymethacrylic Acids / pharmacokinetics. Rats. Tissue Distribution

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  • (PMID = 16274831.001).
  • [ISSN] 0168-3659
  • [Journal-full-title] Journal of controlled release : official journal of the Controlled Release Society
  • [ISO-abbreviation] J Control Release
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Carriers; 0 / Methacrylates; 0 / Oligopeptides; 0 / Polymethacrylic Acids; 0 / acetyl-prolyl-histidyl-seryl-cysteinyl-asparaginamide; 0 / doxorubicin-N-(2-hydroxypropyl)methacrylamide copolymer conjugate; 27813-02-1 / hydroxypropyl methacrylate; 80168379AG / Doxorubicin
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23. Novosad CA: Principles of treatment for vaccine-associated sarcomas. Clin Tech Small Anim Pract; 2003 May;18(2):115-7
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  • [Title] Principles of treatment for vaccine-associated sarcomas.
  • In the last decade, there has been a great deal of information surrounding the etiology, diagnosis, and treatment of feline vaccine-associated sarcomas.
  • The presence of a mass in areas used for subcutaneous or intramuscular injections should alert the clinician to the possibility of a vaccine-associated sarcoma.
  • Early detection and subsequent treatment is paramount to limit local invasion and distant metastasis.
  • The current data are suggesting that a team approach with multi-modality therapy is the appropriate way to address this disease.
  • In the following article, we will discuss the history/incidence, pathology, diagnosis, and current treatment options, which include a combination of surgery, radiation, and chemotherapy for vaccine-associated sarcomas.
  • [MeSH-major] Cat Diseases / chemically induced. Cat Diseases / therapy. Sarcoma / veterinary. Soft Tissue Neoplasms / veterinary. Vaccines / adverse effects
  • [MeSH-minor] Animals. Cats. Combined Modality Therapy / veterinary. Neoplasm Staging / veterinary. Tomography, X-Ray Computed / veterinary. Vaccination / veterinary. Veterinary Medicine

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  • (PMID = 12831073.001).
  • [ISSN] 1096-2867
  • [Journal-full-title] Clinical techniques in small animal practice
  • [ISO-abbreviation] Clin Tech Small Anim Pract
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vaccines
  • [Number-of-references] 18
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24. Hwang S: Imaging of lymphoma of the musculoskeletal system. Radiol Clin North Am; 2008 Mar;46(2):379-96, x
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  • Imaging plays a crucial role in staging and the assessment of treatment response in patients who have lymphoma of the musculoskeletal system.
  • This article reviews imaging features of lymphoma of bone, muscles, cutaneous, and subcutaneous tissue.
  • At CT, lymphoma of muscle can be homogenous in attenuation, and it may not show contrast enhancement, making tumor detection more difficult.
  • Post-treatment changes often are encountered at MR imaging and positron emission tomography, and when considered in light of the patient's therapy regimen (eg, radiation therapy and granulocyte-colony stimulating factor), they usually can be differentiated from tumor.
  • Post-treatment changes include diffuse FDG uptake in marrow after chemotherapy, indicating rebound of normal marrow, and MR imaging signal abnormalities that may persist for anywhere from a few months to years after treatment.
  • [MeSH-major] Bone Neoplasms / diagnosis. Diagnostic Imaging / methods. Lymphoma / diagnosis. Muscle Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Staging

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  • [ReprintIn] Magn Reson Imaging Clin N Am. 2010 Feb;18(1):75-93 [19962094.001]
  • (PMID = 18619386.001).
  • [ISSN] 0033-8389
  • [Journal-full-title] Radiologic clinics of North America
  • [ISO-abbreviation] Radiol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 53
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25. Fender AB, Gust A, Wang N, Scott GA, Mercurio MG: Congenital leukemia cutis. Pediatr Dermatol; 2008 Jan-Feb;25(1):34-7
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  • We describe a premature neonate who was born with pancytopenia and a single subcutaneous nodule on her right lower extremity.
  • A biopsy specimen from the nodule demonstrated a dense infiltrate of pleomorphic mononuclear cells that extended throughout the dermis and into the subcutaneous tissue.
  • Immunohistochemical stains and bone marrow examination confirmed a diagnosis of acute myelogenous leukemia.
  • Induction chemotherapy was started but was complicated by multiorgan failure.
  • As leukemia cutis more typically presents as multiple infiltrative papules, nodules, or plaques, we stress the importance of including leukemia in the differential diagnosis of a solitary nodule in a neonate.
  • [MeSH-major] Infant, Premature. Leukemia, Myeloid, Acute / congenital. Leukemia, Myeloid, Acute / pathology. Neoplasm Invasiveness / pathology. Skin Neoplasms / congenital. Skin Neoplasms / pathology

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  • (PMID = 18304150.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Grundmann JU, Weisshaar E, Franke I, Bonnekoh B, Gollnick H: Lung carcinoma with congenital plantar keratoderma as a variant of Clarke-Howel-Evans syndrome. Int J Dermatol; 2003 Jun;42(6):461-3
Hazardous Substances Data Bank. FLUOROURACIL .

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  • A 32-year-old man was admitted to the Magdeburg University Hospital with icterus and for further diagnosis of suspected hepatitis.
  • Further investigations revealed icterus of the sclera and multiple, firm tumors, which were located in the deep subcutaneous tissue, on the left hip, thigh, and buttock.
  • Chemotherapy could not be continued because of a Karnowsky index below 20%.
  • [MeSH-major] Keratoderma, Palmoplantar / genetics. Lung Neoplasms / drug therapy
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Drug Therapy, Combination. Fatal Outcome. Fluorouracil / therapeutic use. Humans. Male. Mitomycin / therapeutic use. Neoplasm Metastasis

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  • (PMID = 12786874.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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27. Merriman DJ, Deavers MT, Czerniak BA, Lin PP: Massive desmoplastic fibroblastoma with scapular invasion. Orthopedics; 2010 Aug;33(8)

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The growth of this tumor is generally indolent, and most tumors are small, subcutaneous lesions.
  • The aggressive clinical features prompted the original physicians to administer chemotherapy, but the tumor exhibited no response to systemic treatment.
  • [MeSH-major] Fibroma, Desmoplastic / pathology. Scapula / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Combined Modality Therapy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Neoplasm Invasiveness. Tomography, X-Ray Computed. Young Adult

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • [CommentIn] Orthopedics. 2011 Nov;34(11):836-7; author reply 837 [22050246.001]
  • (PMID = 20704102.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Mentzel T, Kuhnen C: Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch; 2006 Nov;449(5):554-60
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  • Five neoplasms were completely excised, in one incompletely excised neoplasm additional chemotherapy was given, and in one patient a biopsy was done only so far.
  • All neoplasms arose in subcutaneous and deep soft tissues with dermal involvement in one case, and the size of the neoplasms ranged from 4 to 19 cm in largest diameter.
  • In summary, spindle cell rhabdomyosarcoma represents a rare neoplasm in adulthood characterized clinically by a rather poor prognosis, and shows a broad morphological spectrum including most likely the sclerosing, pseudovascular variant.
  • Immunohistochemically, tumour cells in RMS stain positively for CD 99 and WT1 as well, which is of importance in the differential diagnosis to other mesenchymal neoplasms, whereas fast myosin does not represent a reliable marker for RMS in adults.
  • [MeSH-major] Rhabdomyosarcoma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD99; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules
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29. Kanemoto K, Satoh H, Yamashita YT, Ishikawa H, Kamma H, Ohtsuka M, Sekizawa K: Late recurrence of small-cell lung cancer: a case report. Am J Clin Oncol; 2000 Oct;23(5):473-5
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient was given four courses of platinum-containing chemotherapy followed by chest irradiation, and good partial response (PR) was obtained.
  • The patient did well for 4 years, until he sought treatment for a painful subcutaneous tumor.
  • Chest computed tomography scan revealed the mass extending from the tumor in lung parenchyma with osteolytic lesion of the third rib bone.
  • Pathologic examination of the subcutaneous lesion revealed SCLC.
  • The patient was given two courses of the same combination chemotherapy administered as initial therapy.
  • [MeSH-major] Carcinoma, Small Cell / therapy. Lung Neoplasms / therapy. Neoplasm Recurrence, Local / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Combined Modality Therapy. Humans. Male. Osteolysis. Ribs

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  • (PMID = 11039506.001).
  • [ISSN] 0277-3732
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] UNITED STATES
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30. Angst E, Chen M, Mojadidi M, Hines OJ, Reber HA, Eibl G: Bioluminescence imaging of angiogenesis in a murine orthotopic pancreatic cancer model. Mol Imaging Biol; 2010 Dec;12(6):570-5
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • New approaches to cancer therapy include targeting angiogenesis.
  • PROCEDURES: Live in vivo bioluminescence imaging of angiogenesis was performed continuously until sacrifice in subcutaneous tumors as well as in orthotopically transplanted tumors.
  • Tumor tissue was immunostained for CD-31 and VEGFR2.
  • RESULTS: Peritumoral angiogenesis measured by light emission was detected beginning at week 3 following subcutaneous injection.

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  • (PMID = 20376570.001).
  • [ISSN] 1860-2002
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] ENG
  • [Grant] United States / NCCIH NIH HHS / AT / AT003960-03; United States / NCI NIH HHS / CA / R01 CA122042-04; United States / NCI NIH HHS / CA / CA122042-03; United States / NCI NIH HHS / CA / R01 CA104027-04; United States / NCCIH NIH HHS / AT / P01 AT003960-03; United States / NCI NIH HHS / CA / R01 CA104027; United States / NCI NIH HHS / CA / R21 CA124609; United States / NCCIH NIH HHS / AT / P01 AT003960; United States / NCI NIH HHS / CA / R01 CA122042; United States / NCI NIH HHS / CA / CA104027-04; United States / NCCIH NIH HHS / AT / P01AT003960; United States / NCI NIH HHS / CA / CA122042-04; United States / NCI NIH HHS / CA / R01 CA122042-03
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Luminescent Proteins
  • [Other-IDs] NLM/ NIHMS199684; NLM/ PMC2917614
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31. Nakahashi H, Tsukamoto N, Yamane A, Saitoh T, Uchiumi H, Handa H, Karasawa M, Murakami H, Kojima M, Nojima Y: Autologous peripheral blood stem cell transplantation to treat CHOP-refractory aggressive subcutaneous panniculitis-like T cell lymphoma. Acta Haematol; 2009;121(4):239-42
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Autologous peripheral blood stem cell transplantation to treat CHOP-refractory aggressive subcutaneous panniculitis-like T cell lymphoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, T-Cell, Cutaneous / surgery. Peripheral Blood Stem Cell Transplantation. Skin Neoplasms / surgery
  • [MeSH-minor] Asparaginase / administration & dosage. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Dexamethasone / administration & dosage. Doxorubicin / administration & dosage. Doxorubicin / analogs & derivatives. Drug Resistance, Neoplasm. Humans. Male. Neoplasm Invasiveness. Panniculitis / diagnosis. Prednisone / administration & dosage. Salvage Therapy. Subcutaneous Tissue. Transplantation, Autologous. Vincristine / administration & dosage. Young Adult






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