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Items 1 to 26 of about 26
1. Zhu S, Li Y, Liu G, Han X, Gong L, Yao L, Lan M, Zhang W: Primary lung seminoma in a 76-year-old man: a case report. Int J Clin Exp Pathol; 2010;3(7):730-5
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  • [Title] Primary lung seminoma in a 76-year-old man: a case report.
  • In this report, we present a rare case of primary seminoma in the lung of a 76-years-old man.
  • The Chest Routine Scan and CT showed there was a consolidation area in the basal segments at the lower lobe of left lung.
  • Bronchoscope also exhibited a neoplasm in left lung.
  • During left lower lobectomy, we found that adherence occurred widely in left thoracic wall, and the pleural membrane was shrinkage.
  • No chemotherapy or radiotherapy was given.
  • Patient was died at 140 days after the surgery mainly due to the dyscrasia and secondary seminoma in left 7th to 9th ribs.
  • CONCLUSION: Although primary seminoma of the lung is rare in old male population, the diagnosis should be taken into serious consideration in order to improve the treatment.
  • And in this case, primary lung seminoma is associated with high degree of malignancy and metastasis.
  • [MeSH-major] Lung Neoplasms / pathology. Seminoma / secondary

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  • (PMID = 20830245.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2933394
  • [Keywords] NOTNLM ; Seminoma / immunohistochemistry / lung
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2. Ou SH, Zell JA, Ziogas A, Anton-Culver H: Prognostic factors for survival of stage I nonsmall cell lung cancer patients : a population-based analysis of 19,702 stage I patients in the California Cancer Registry from 1989 to 2003. Cancer; 2007 Oct 1;110(7):1532-41
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  • [Title] Prognostic factors for survival of stage I nonsmall cell lung cancer patients : a population-based analysis of 19,702 stage I patients in the California Cancer Registry from 1989 to 2003.
  • BACKGROUND: Platinum-based adjuvant chemotherapy in randomized trials has failed to provide a survival benefit in patients with resected stage I nonsmall cell lung cancer (NSCLC).
  • Patient demographic factors, tumor characteristics, and treatment delivered were examined.
  • RESULTS: Advanced age at diagnosis, male sex, low socioeconomic status (SES), nonsurgical treatment, and poor histologic grade (stage IA NSCLC: hazards ratio [HR], 1.13; 95% confidence interval [95% CI], 1.08-1.19; stage IB NSCLC: HR, 1.11; 95% CI, 1.07-1.16) were associated with increased mortality risk on multivariate analysis.
  • Non-upper lobe tumor location (right middle lobe, right and left lower lobes) and tumor size > or =4 cm (vs <4 cm: HR, 1.23; 95% CI, 1.15-1.30) were additional factors that increased the risk of mortality among patients with stage IB disease.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / mortality. Lung Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / mortality. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adult. Aged. Asian Americans / statistics & numerical data. California / epidemiology. Carcinoma, Large Cell / mortality. Carcinoma, Large Cell / pathology. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Pneumonectomy / methods. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Registries. Risk Assessment. Risk Factors. Survival Rate

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  • (PMID = 17702091.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Geiger J, Walter K, Uhl M, Bley TA, Jüttner E, Brink I, Kirschbaum A, Kontny U: Imaging findings in a 3-year-old girl with type III pleuropulmonary blastoma. In Vivo; 2007 Nov-Dec;21(6):1119-22
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  • [Title] Imaging findings in a 3-year-old girl with type III pleuropulmonary blastoma.
  • Pleuropulmonary blastoma (PPB) is a rare dysembryonic intrathoracic neoplasm in children.
  • We report on a 3-year-old girl who presented with respiratory symptoms and was diagnosed as having a type III PPB according to histological results attained by open biopsy.
  • Imaging by CT and MRI revealed the exact size of the tumour involving the left lower lobe with displacement of the mediastinum and the diaphragm.
  • Additional FDG-PET was important to evaluate tumour vitality and to decide the time of surgery, which was performed after 12 weeks of chemotherapy with the CWS2002P protocol.
  • After R0 resection without complications and postoperative chemotherapy, the child continues to be in complete remission.
  • This case underlines the importance of radical surgery of the aggressive neoplasm in combination with chemotherapy and the usefulness of multimodal imaging for the optimal planning of local therapy.
  • [MeSH-major] Lung Neoplasms / diagnosis. Pleural Neoplasms / diagnosis
  • [MeSH-minor] Child, Preschool. Female. Humans. Magnetic Resonance Imaging. Positron-Emission Tomography. Tomography, X-Ray Computed


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4. Kara Gedik G, Sari O, Altinok T, Tavli L, Kaya B, Ozcan Kara P: Askin's Tumor in an Adult: Case Report and Findings on 18F-FDG PET/CT. Case Rep Med; 2009;2009:517329

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  • Primitive neuroectodermal tumor (PNET) of the chest wall or Askin's tumor is a rare neoplasm of chest wall.
  • The patient was admitted with a history of 3-month lower back pain and cough.
  • In computed tomography, there was a lesion with dimensions of 70 x 40 x 65 mm in the superior segment of the lower lobe of the left lung.
  • Positron emission tomography/computed tomography with 18F-flourodeoxyglucose revealed a pleural-based tumor in the left lung with a maximum standardized uptake value of 4.36.
  • The patient had gone through surgery, and wedge resection of the superior segment of left lobe and partial resection of the ipsilateral ribs were performed.
  • Pathology report with immunocytochemistry was consistent with PNET and the patient received chemotherapy after that.

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  • (PMID = 20049330.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2797374
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5. Guerrero A, Laflamme M, Agoff SN, Williams WM, Karmy-Jones R: Primary lymphoepithelioma-like carcinoma of the lung. Can Respir J; 2001 Nov-Dec;8(6):431-3
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  • [Title] Primary lymphoepithelioma-like carcinoma of the lung.
  • Primary lymphoepithelioma-like carcinoma (LELC) of the lung is a neoplasm seen most commonly in the nasopharynx of individuals from south China and Taiwan, and is strongly associated with the Epstein-Barr virus.
  • The case of a 62-year-old Chinese man with a rare primary lung T2N1M0 LELC of the left lower lobe is presented.
  • After it was determined that the neoplasm was of primary lung origin, adjunctive chemotherapy was initiated.
  • The role of adjunctive chemotherapy in this setting is discussed.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Granuloma, Respiratory Tract / pathology. Lung Neoplasms / pathology

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  • (PMID = 11753457.001).
  • [ISSN] 1198-2241
  • [Journal-full-title] Canadian respiratory journal
  • [ISO-abbreviation] Can. Respir. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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6. Tanimura S, Tsutsumi K, Okura M, Tanaka N, Yamamoto H, Honma K, Aida Y: [Successful removal of T4 lung cancer with left atrial invasion after induction chemotherapy]. Kyobu Geka; 2005 Oct;58(11):988-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Successful removal of T4 lung cancer with left atrial invasion after induction chemotherapy].
  • The chest X-ray revealed a large mass shadow in the right lower lobe.
  • Massive tumor extending into the left atrium was diagnosed by computed tomography (CT).
  • The effect of the chemotherapy was complete response, enabling the surgical treatment.
  • The right pneumonectomy with partial resection of the left atrium was performed by using vascular clamp.
  • The defect of the left atrium could be sutured directly.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / pathology. Heart Neoplasms / pathology. Lung Neoplasms / pathology. Pneumonectomy
  • [MeSH-minor] Cardiac Surgical Procedures. Cisplatin / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Drug Administration Schedule. Heart Atria. Humans. Male. Middle Aged. Neoplasm Invasiveness. Paclitaxel / administration & dosage

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  • (PMID = 16235848.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 17
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7. Shimizu J, Ikeda C, Arano Y, Adachi I, Morishita M, Yamaguchi S, Ishikawa N, Watanabe G, Minato H: Advanced lung cancer invading the left atrium, treated with pneumonectomy combined with left atrium resection under cardiopulmonary bypass. Ann Thorac Cardiovasc Surg; 2010 Aug;16(4):286-90
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  • [Title] Advanced lung cancer invading the left atrium, treated with pneumonectomy combined with left atrium resection under cardiopulmonary bypass.
  • Based on a bronchoscopic biopsy, it was diagnosed at a nearby clinic as an advanced left lung cancer, and he was referred to our hospital.
  • Chest computed tomography (CT) scans demonstrated a giant mass of the left lower lobe, 14 × 12 cm in size, which appeared to have invaded the left atrium (LA).
  • The patient underwent left pneumonectomy combined with LA resection using cardiopulmonary bypass (CPB), without aortic clamping, through left posterolateral thoracotomy under hypothermia (32 °C).
  • His postoperative course was uneventful, and he received 2 courses of adjuvant chemotherapy.
  • If CPB is used, the tension of the LA is removed by blood extraction into the bypass, and bradycardia is induced by a reduction of body temperature, probably reducing the risk of clamp dislocation.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Heart Neoplasms / surgery. Lung Neoplasms / surgery
  • [MeSH-minor] Aged. Cardiac Surgical Procedures. Cardiopulmonary Bypass. Heart Atria / pathology. Humans. Male. Neoplasm Invasiveness. Pneumonectomy

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  • (PMID = 21057449.001).
  • [ISSN] 2186-1005
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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8. Morawietz L, Kuhnen C, Katenkamp D, Le Coutre P, Ladhoff A, Petersen I: Unusual sarcomatoid neoplasm of the lung suggesting a myofibrosarcoma. Virchows Arch; 2005 Dec;447(6):990-5
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  • [Title] Unusual sarcomatoid neoplasm of the lung suggesting a myofibrosarcoma.
  • Myofibrosarcoma is a rare neoplasm that occurs mainly in the head and neck region and extremities of middle-aged patients.
  • We report the case of a 47-year-old male patient with a malignant mesenchymal pulmonary tumor affecting almost the entire lower left lobe.
  • Clinically suggestive for a lung carcinoma, the tumor showed typical features of a myofibrosarcoma.
  • Shortly after resection of the primary tumor, the patient showed multiple distant metastases in the contralateral lung, the mediastinal lymph nodes, the left adrenal gland, and the pectoral and deltoid muscle, which responded well to chemotherapy.
  • The case report will discuss the evidence for the final diagnosis of a primary pulmonary myofibrosarcoma and the differential diagnosis of sarcomatoid tumors of the lung.
  • [MeSH-major] Fibrosarcoma / pathology. Lung Neoplasms / pathology. Myosarcoma / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged. Nucleic Acid Hybridization. Pneumonectomy. Sarcoma / pathology

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  • (PMID = 16158184.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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9. Chang JW, Chou CL, Huang SF, Wang HM, Hsieh JJ, Hsu T, Cheung YC: Erlotinib response of EGFR-mutant gefitinib-resistant non-small-cell lung cancer. Lung Cancer; 2007 Dec;58(3):414-7
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  • [Title] Erlotinib response of EGFR-mutant gefitinib-resistant non-small-cell lung cancer.
  • Here we report a case whose active EGFR-mutant NSCLC responded to erlotinib treatment.
  • PATIENT AND METHODS: Lung specimen was obtained during diagnostic procedures from a 41-year-old Taiwanese male smoker with adenocarcinoma.
  • He received cisplatin-based chemotherapy following craniotomy to remove his brain metastasis.
  • Tumor progressed in both lung and left adrenal gland.
  • He underwent second-line docetaxel chemotherapy.
  • Complete regression of the lung tumor and partial response of the left adrenal gland mass was achieved.
  • Nine months later, the left lower lobe lung tumor and left adrenal gland tumor progressed.
  • A lung biopsy from the left lower lobe disclosed an adenocarcinoma which harbored an in-frame deletion in exon 19 (heterozygous delE746-A750) of EGFR without a second mutation such as T790M in exon 20.
  • RESULTS: This patient achieved a partial response to erlotinib treatment.
  • He remained on erlotinib for a total of 18 months until the left adrenal gland tumor progressed.
  • CONCLUSIONS: This case demonstrated that NSCLC bearing in-frame deletion in exon 19 of EGFR may respond to erlotinib treatment following gefitinib failure.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / drug therapy. Carcinoma, Non-Small-Cell Lung / genetics. Drug Resistance, Neoplasm / drug effects. Lung Neoplasms / drug therapy. Lung Neoplasms / genetics. Quinazolines / therapeutic use. Receptor, Epidermal Growth Factor / genetics
  • [MeSH-minor] Adult. Amino Acid Sequence. Base Sequence. Erlotinib Hydrochloride. Humans. Male. Mutation. Tomography, X-Ray Computed

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  • (PMID = 17618013.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
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10. Amin RM, Kokubo T, Hiroshima K, Narita M, Itou K, Kuroki M, Tanizawa T, Nakatani Y: Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma. Pathol Int; 2005 Oct;55(10):649-54
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  • [Title] Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma.
  • Two years after testicular resection was carried out in a 40-year-old man that revealed mixed germ cell tumor of more than one histological type (seminoma, embryonal cell carcinoma, and yolk sac tumor), he presented with an asymptomatic pulmonary nodule in his left lower lobe.
  • Video-assisted thoracoscopic partial resection of the tumor revealed a 24 x 20 mm teratoma with somatic-type malignancy in which pleomorphic rhabdomyosarcoma was a major element.
  • Throughout the course there was no abdominal lymph node swelling detected by computed tomography (CT) and tumor markers were normal.
  • Adjuvant chemotherapy was started after the tumor recurrence.
  • Currently, the patient is still undergoing chemotherapy 5 months after the tumor recurrence.
  • In conclusion, despite the fact that primary pulmonary rhabdromyosarcoma is a rare neoplasm, metastatic pulmonary germ cell tumor with somatic-type malignancy showing predominantly rhabdomyosarcomatous differentiation should be considered in the differential diagnosis of such lesions of the lung.
  • [MeSH-major] Lung Neoplasms / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Rhabdomyosarcoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Male. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 16185296.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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11. Munzuroglu F, Erturan S, Oz B, Dincbas FO, Demir G: Non small cell lung cancer within the small cell lung cancer radiotherapy field after 11 years. J BUON; 2009 Apr-Jun;14(2):313-6
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  • [Title] Non small cell lung cancer within the small cell lung cancer radiotherapy field after 11 years.
  • A 71-year-old male was diagnosed with a non-small cell lung cancer (NSCLC) within the radiotherapy field that was used for the treatment of a small cell lung cancer (SCLC) 11 years ago.
  • At the initial diagnosis in 1996 the patient had limited-stage SCLC located in the right upper lobe of the lung with mediastinal involvement.
  • He received 4 cycles of chemotherapy and then mediastinal radiotherapy.
  • After 11 years of disease-free period a new mass in left lower lobe of the lung was detected.
  • Bronchoscopic biopsy showed second lung cancer with epidermoid histology.
  • Although the incidence of a second lung cancer is higher in SCLC survivors, this is a unique case in the literature with second NSCLC developing in the previously irradiated side of limited-stage SCLC.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Non-Small-Cell Lung / etiology. Lung Neoplasms / diagnosis. Neoplasms, Second Primary / etiology. Small Cell Lung Carcinoma / diagnosis
  • [MeSH-minor] Aged. Combined Modality Therapy. Cranial Irradiation. Humans. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / drug therapy

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  • (PMID = 19650185.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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12. Sonobe M, Bando T, Date H: Peripheral primitive neuroectodermal tumour of the chest wall invading lung with regional lymph node metastasis. Eur J Cardiothorac Surg; 2009 Jan;35(1):185-7

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  • [Title] Peripheral primitive neuroectodermal tumour of the chest wall invading lung with regional lymph node metastasis.
  • Here we present the case of a 26-year-old man in whom peripheral primitive neuroectodermal tumour of chest wall origin invaded the left lung with regional lymph node metastasis.
  • He underwent initial resection of the left chest wall tumour with combined left lower lobectomy, left S5 segmentectomy, and lymph node dissection in order to facilitate a definitive diagnosis and also to obviate the risk of fatal bleeding due to tumour invasion of the pulmonary artery.
  • Histological examination of the resected sample revealed small round cell proliferation with neural differentiation, and confirmed lymph node involvement within the left lower lobe.
  • Diagnosis of peripheral primitive neuroectodermal tumour was confirmed.
  • After surgery, combination chemotherapy with cyclophosphamide, vincristine, doxorubicin, ifosphamide, and etoposide was given.
  • [MeSH-major] Lung / pathology. Neuroectodermal Tumors, Primitive, Peripheral / pathology. Thoracic Neoplasms / pathology. Thoracic Wall
  • [MeSH-minor] Adult. Humans. Lymphatic Metastasis. Male. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 19036597.001).
  • [ISSN] 1873-734X
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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13. Uçgun I, Akçayir Sahin I, Metintaş M, Alataş F, Erginel S, Dündar E: [Synchronous primary lung cancers: due to the four cases]. Tuberk Toraks; 2004;52(3):262-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Synchronous primary lung cancers: due to the four cases].
  • If two primary lung cancers are present in the same time, it diagnosed as synchronous lung cancer.
  • It constitutes 0.1-1.6% of all lung cancers.
  • In this report, we described four cases diagnosed synchronous multiple primary lung cancers (MPLC) in between June 1999 and May 2002.
  • Histology of lung cancers was squamous-adeno in two cases, squamous-small cell lung cancer in one case, and squamous-squamous in two cases.
  • Lesion of second primary lung cancer was unable to seen in two patient's chest X-ray.
  • Their lesions were seen by computerized tomography in one case, and by bronchoscope only in the other case.
  • Lesion site was left lower lobe, right lower lobe, right middle lobe, and left upper lobe (25% for each).
  • Diagnosis of lung cancer was made by transthoracic needle biopsy in three lesion, and made by bronchoscopic biopsy in other lesions.
  • While it is recommended that, all of MPLC lesions were staged separately and treated surgically, due to the advanced age, presence of small cell lung cancer, and inadequate post-operative respiratory reserve, surgical treatment could not apply to these patients and they received chemotherapy.
  • Due to the this report, we emphasized that diagnostic procedures should be done separately for each lesions in patients who had more than one lesion, and treatment should plane according to these results.
  • [MeSH-major] Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / drug therapy. Adenocarcinoma / radiography. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bronchoscopy. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / drug therapy. Carcinoma, Small Cell / radiography. Diagnosis, Differential. Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasms, Squamous Cell / diagnosis. Neoplasms, Squamous Cell / drug therapy. Neoplasms, Squamous Cell / radiography. Smoking / adverse effects. Tomography, X-Ray Computed

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  • (PMID = 15351940.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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14. Krieghoff B, Skuballa A, Leonhardt P, Mohr FW, Wittekind C, Bossert T, Achatzy R: [Primary synovial sarcoma of the lung - a rare tumor]. Zentralbl Chir; 2002 Aug;127(8):716-9
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  • [Title] [Primary synovial sarcoma of the lung - a rare tumor].
  • We present a 26 year old patient with a primary malignant synovial sarcoma of the lung that was observed for more than one year by a general practitioner and a pulmologist.
  • Finally, because of recurrent hemoptysis a central tumor of mesenchymal origin of the left lower lobe was diagnosed by bronchoscopy.
  • The invasion of the left atrium as far as to the mitral valve was diagnosed by MRT.
  • The partial excision of the left atrium required plastic reconstruction.
  • In the postoperative course the patient underwent chemo-therapy, 6 cycles adriablastine/ifosfamid.
  • The patient refused further radio- or chemotherapy and died 14 months after the operation.
  • Because of the small number of cases therapeutic strategy conceptions do not exist.
  • [MeSH-major] Lung Neoplasms / surgery. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adult. Bronchoscopy. Diagnosis, Differential. Diagnostic Imaging. Humans. Lung / pathology. Male. Neoplasm Staging. Pneumonectomy

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  • (PMID = 12200737.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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15. Yonemori K, Kunitoh H, Sekine I: Small-cell lung cancer with lymphadenopathy in an 18-year-old female nonsmoker. Nat Clin Pract Oncol; 2006 Jul;3(7):399-403; quiz following 403
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  • [Title] Small-cell lung cancer with lymphadenopathy in an 18-year-old female nonsmoker.
  • BACKGROUND: An asymptomatic 18-year-old female presented in December 2002 with a left pulmonary mass, and an enlarged mediastinum and left hilum, detected on a routine chest X-ray.
  • A CT scan of the chest disclosed a round tumor in the left lower lobe and marked enlargement of the ipsilateral hilar and mediastinal lymph nodes.
  • INVESTIGATIONS: CT scan of the chest, routine hematological study, sputum smear and culture for acid-fast bacilli, transbronchial lung biopsy, serum tumor markers, CT scan of the abdomen, MRI scan of the head, bone scintigraphy, lung function tests, blood gas analysis, pathological examination including hematoxylin-eosin staining and immunohistochemistry using chromogranin A, CD56 (neural cell adhesion molecule), and cytokeratin antibodies.
  • DIAGNOSIS: Limited-stage small-cell lung cancer (T1N2M0, clinical stage IIIA).
  • MANAGEMENT: Etoposide plus cisplatin chemotherapy with concurrent accelerated hyperfractionated thoracic radiotherapy, left pneumonectomy and lymph-node dissection.
  • [MeSH-major] Carcinoma, Small Cell. Lung Neoplasms. Lymphatic Diseases
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Diagnosis, Differential. Etoposide / administration & dosage. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / therapy. Neoplasm Staging. Pneumonectomy. Radiotherapy, Adjuvant. Smoking


16. Liu K, Chen HL, You QS, Huang JF, Wang H: [Clinical analysis of skip N2 metastases in stage IIIA non-small cell lung cancer]. Ai Zheng; 2009 Jul;28(7):725-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of skip N2 metastases in stage IIIA non-small cell lung cancer].
  • BACKGROUND AND OBJECTIVE: Clinical characteristics of skip N2 metastasis of stage IIIA non-small cell lung cancer (NSCLC) are not clear.
  • Moreover, the relationship between the primary tumor location and N2 positive lymph nodes were described as follows: right upper lobe cancer displayed skip-N2 nodal metastasis mostly in the 3rd and 4th station (85.7%), right middle lobe mostly in the 7th station(75.0%), right lower lobe mostly in the 3rd and 7th station(81.0%), left upper lobe mostly in the 5th and 6th station(80.0%), and left lower lobe mostly in the 7th station (65.0%).
  • Survival analysis showed that skip N2 metastasis was an independent risk factor of stage IIIA NSCLC in addition to tumor size, histology, type of resection, adjuvant chemotherapy and radiotherapy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Lymph Nodes / pathology
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Lung. Lymph Node Excision. Lymphatic Metastasis. Male. Mediastinum. Middle Aged. Neoplasm Staging. Pneumonectomy / methods. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Risk Factors. Survival Rate

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  • (PMID = 19624899.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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17. Nakagawa K: [An elderly patient with non-resectable lung cancer responding to TS-1]. Gan To Kagaku Ryoho; 2006 Nov;33(11):1615-8
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  • [Title] [An elderly patient with non-resectable lung cancer responding to TS-1].
  • A 76-year-old man had complained of hoarseness, productive cough and left chest pain in June 2005.
  • Chest radiograph and computed tomography showed a tumor 7.5x5 cm in size which contacted the aortic arch, some nodules in left upper lobe and right lower lobe of lung and left pleural effusion.
  • The broncho-fiberscopic biopsy histologically proved the tumor to be moderately differentiated squamous cell carcinoma in the left upper lobe of lung.
  • The patient was diagnosed as a non-resectable lung cancer with clinical stage IV (c-T4N2M1).
  • After this modulation of the treatment, he could take TS-1 and Jyu-zen daiho toh days 1-14, every 3 weeks.
  • The left pleural effusion and left chest pain disappeared only 2 weeks after taking TS-1.
  • In June of 2006, central necrosis of the left lung tumor was confirmed by positron emission computed tomography.
  • This case suggests that TS-1 with Jyu-zen daiho toh may be an effective treatment for elderly advanced lung cancer.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Lung Neoplasms / drug therapy. Oxonic Acid / therapeutic use. Tegafur / therapeutic use
  • [MeSH-minor] Aged. Drug Administration Schedule. Drug Combinations. Drugs, Chinese Herbal / administration & dosage. Humans. Male. Neoplasm Staging. Quality of Life

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  • (PMID = 17108728.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0 / Drugs, Chinese Herbal; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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18. Schaeffer CJ, Minai OA, Sharma N, Kanne JP, Mohammed TL: Inflammatory myofibroblastic tumor of the lung: recurrence after steroid treatment. J Thorac Imaging; 2008 Aug;23(3):191-3
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  • [Title] Inflammatory myofibroblastic tumor of the lung: recurrence after steroid treatment.
  • We report a case of a patient with inflammatory myofibroblastic tumor of the lung, which recurred after steroid treatment.
  • The diagnosis of the tumor was confirmed by a core needle lung biopsy and pathology.
  • The patient was initiated on steroid therapy, which on complete response was slowly tapered and discontinued.
  • Chest radiography and computed tomography scans depicted recurrence at the tumor resection site in the right lobe of lung and a new tumor in the left lower lobe.
  • Restarting the steroid therapy, led to regression of the tumors at both sites.
  • This is a rare case of inflammatory myofibroblastic tumor recurring poststeroid therapy and adds to the current clinical knowledge about this peculiar manifestation of this disease entity.
  • [MeSH-major] Granuloma, Plasma Cell / drug therapy. Inflammation. Lung / radiography. Lung Neoplasms / drug therapy. Neoplasm Recurrence, Local. Neoplasms, Muscle Tissue / drug therapy. Steroids / therapeutic use
  • [MeSH-minor] Dyspnea / complications. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18728547.001).
  • [ISSN] 1536-0237
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Steroids
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19. Nakajima Y, Koizumi K, Hirata T, Hirai K, Fukushima M, Yamagishi S, Kawashima T, Kinoshita H, Shimizu K: Long-term survival of Askin tumor for 10 years with 2 relapses. Ann Thorac Cardiovasc Surg; 2006 Apr;12(2):137-40
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  • Thoracic CT detected a tumor in contact with the left thoracic wall, and tumorectomy was performed in May 1995.
  • After surgery, the thoracic wall to which the tumor adhered was treated with irradiation at 50 Gy.
  • Chemotherapy was considered, but the patient did not wish to undergo this treatment.
  • Lung metastasis occurred 5 years after the first surgery, and the left lower lobe of the lung was partially resected.
  • Four years later, lobectomy of the left lower lobe of the lung was performed, due to further lung metastasis.
  • [MeSH-major] Lung Neoplasms / secondary. Neuroectodermal Tumors, Primitive / pathology. Sarcoma, Ewing / pathology. Thoracic Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Neoplasm Metastasis. Neoplasm Recurrence, Local. Survivors

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  • (PMID = 16702938.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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20. Demura Y, Saito H, Yashiki N: [Chondrosarcoma of the rib with pleural dissemination]. Kyobu Geka; 2009 May;62(5):399-403
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  • A 52-year-old woman was admitted to the hospital because of abnormal shadow of the left lung.
  • Chest computed tomography (CT) showed a 10.0 x 6.6 cm mass arising from the left chest wall.
  • The diagnosis of grade II chondrosarcoma was made with CT guided percutaneous needle biopsy.
  • Chest wall resection and partial resection of the left lower lobe including the tumor was performed.
  • Adjuvant chemotherapy using OK-432, carboplatin and etoposide was tried as treatment for pleural dissemination.
  • Multidisciplinary approach including resection of a primary tumor has potential to improve prognosis in some cell types.
  • And long term follow-up is necessary to determine effectiveness of adjuvant chemotherapy in this case.
  • [MeSH-major] Chondrosarcoma / pathology. Neoplasm Seeding. Pleural Neoplasms / secondary. Ribs. Thoracic Neoplasms / pathology

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  • (PMID = 19425383.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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21. Zhang LB, Sun YE, Yu CH, Liu Y: [Clinical diagnosis and surgical treatment of primary pulmonary lymphoma]. Zhonghua Wai Ke Za Zhi; 2006 Jan 15;44(2):97-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical diagnosis and surgical treatment of primary pulmonary lymphoma].
  • OBJECTIVE: To study the clinical characteristics, the principles of diagnosis and surgical treatment for primary pulmonary lymphoma.
  • METHOD: Ten patients with primary pulmonary lymphoma were treated surgically and their clinical characteristics, the experiences of clinical diagnosis and surgical treatment were analyzed.
  • The tumors located in left upper lobe in 2, left lower lobe in 1, right upper lobe in 3, right middle lobe in 3 and right lower lobe in 1.
  • All cases with non-Hodgkin's lymphoma received regular chemotherapy (MOPP and ABVD scheme for 1 case with Hodgkin's disease respectively, CHOP for 8 cases with non-Hodgkin's lymphoma), and 3 cases received radiotherapy postoperatively.
  • RESULTS: Eight cases were non-Hodgkin's lymphoma (B-type) and 2 cases were Hodgkin's disease (mixed type) confirmed by pathological examination.
  • Two cases with non-Hodgkin's lymphoma (stage II 2E, B-cell, low-grade) and 2 cases with Hodgkin's disease (stage IE and II 2E, mixed type) died in 24, 32, 8 and 17 months postoperatively respectively.
  • CONCLUSIONS: Primary pulmonary lymphoma is a rare type of malignant lung neoplasm without special clinical features.
  • The preoperative diagnosis is difficult.
  • Treatment modalities include surgical treatment, radiotherapy and regular chemotherapy postoperatively.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lung Neoplasms / surgery. Lymphoma / diagnosis. Lymphoma / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Lymph Node Excision. Male. Middle Aged. Pneumonectomy / methods. Retrospective Studies

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  • (PMID = 16620666.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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22. Tamesue K, Hara K, Hara F, Nakajima T: Pericardial reconstruction using a pedicle flap of the diaphragmatic central tendon. Jpn J Thorac Cardiovasc Surg; 2005 Sep;53(9):494-7
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  • Chest computed tomography and magnetic resonance imaging revealed a lobulated tumor arising from the left lower lobe.
  • At operation, the tumor tissue was found to have invaded the lingula and pericardium, involving the left phrenic nerve.
  • Resection of the left lower lobe, lingula and pericardium including the phrenic nerve was performed for extended pulmonary malignancy.
  • The postoperative histological diagnosis was pulmonary adenocarcinoma with sarcomatous elements [pT3N2M0].
  • At present, 43 months after the operation, the patient is receiving chemotherapy after having undergone cyberknife radiotherapy for brain metastasis of the tumor.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Brain Neoplasms / secondary. Brain Neoplasms / therapy. Female. Humans. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Middle Aged. Neoplasm Invasiveness. Pneumonectomy

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  • [Cites] Ann Thorac Surg. 1993 Mar;55(3):756-7 [8452443.001]
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  • (PMID = 16200891.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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23. Boroumand N, Raja V, Jones DV, Haque AK: SYT-SSX2 variant of primary pulmonary synovial sarcoma with focal expression of CD117 (c-Kit) protein and a poor clinical outcome. Arch Pathol Lab Med; 2003 Apr;127(4):e201-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pulmonary synovial sarcoma is a rare neoplasm recently recognized as a distinct entity and characterized by t(X;18) translocation and production of at least 2 fusion genes, SYT-SSX1 and SYT-SSX2.
  • Previous reports have suggested that the soft tissue synovial sarcomas with SYT-SSX2 phenotype have a favorable clinical outcome.
  • A 45-year-old woman presented with left chest pain and was found to have a left lower lobe tumor that was originally diagnosed as a sarcomatoid carcinoma.
  • After the patient underwent chemotherapy and brachytherapy, the specimen from a left pneumonectomy showed a large spindle cell tumor, which was reclassified as a synovial sarcoma based on the results of immunophenotyping and molecular genetic studies.
  • Differentiation between sarcoma and carcinosarcoma is crucial for implementing appropriate therapy.
  • Furthermore, if the tumor expresses c-Kit, it may respond to target-based therapy.
  • [MeSH-major] Genetic Variation / genetics. Lung Neoplasms / diagnosis. Lung Neoplasms / genetics. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Proteins c-kit / biosynthesis. Sarcoma, Synovial / diagnosis. Sarcoma, Synovial / genetics

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  • (PMID = 12683902.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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24. Xia R, Chen X: Effects of Danshen injection on the malignant obstructive jaundice in the SD rat model. J Huazhong Univ Sci Technolog Med Sci; 2006;26(6):686-9
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  • The liver function, morphological changes and the expressions of PCNA, VEGF and ICAM-1 in carcinoma foci, peri-carcinoma tissues, adjacent lobe (left-internal lobe) and lung tissues were observed after the treatment with the 4 agents.
  • The expressions of PCNA,VEGF and ICAM-1 PCNA, VEGF and ICAM-1 in carcinoma foci, peri-carcinoma tissues, adjacent lobe (left-internal lobe) and lung tissues were lower than those in control group and InV group, with the differences being significant (P<0.01).
  • [MeSH-major] Drugs, Chinese Herbal / therapeutic use. Jaundice, Obstructive / drug therapy. Phenanthrolines / therapeutic use
  • [MeSH-minor] Animals. Carcinoma, Hepatocellular / complications. Disease Models, Animal. Intercellular Adhesion Molecule-1 / metabolism. Liver / pathology. Liver Neoplasms / complications. Male. Neoplasm Metastasis. Proliferating Cell Nuclear Antigen / metabolism. Rats. Rats, Wistar. Vascular Endothelial Growth Factor A / metabolism

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  • [Cites] Ai Zheng. 2003 Dec;22(12):1363-6 [14693071.001]
  • (PMID = 17357489.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Phenanthrolines; 0 / Proliferating Cell Nuclear Antigen; 0 / Vascular Endothelial Growth Factor A; 0 / vascular endothelial growth factor A, rat; 126547-89-5 / Intercellular Adhesion Molecule-1; 79483-68-4 / dan-shen root extract
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25. Gundling F, Zillinger C, Schmidt T, Ingrisch H, Heitland W, Nerlich A, Schepp W: [A 67-year-old patient with diarrhoea and constipation without any pathological findings in virtual colonoscopy]. Z Gastroenterol; 2005 May;43(5):455-9
MedlinePlus Health Information. consumer health - Intestinal Obstruction.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] 67-jähriger Patient mit paradoxer Diarrhoe und unauffälliger virtueller Koloskopie.
  • A 67-year-old patient was admitted to our hospital because of diarrhoea and constipation, associated with abdominal pain in the lower right abdomen.
  • Staging showed peritoneal carcinosis with infiltration of the right ureter and lymphangiosis carcinomatosa of the pectoral lobe of the left lung.
  • After right hemicolectomy because of metastasised carcinoma of the ascending colon (pT4pN1pM1) we started palliative chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.
  • Conventional video-colonoscopy remains the gold standard for the diagnosis of colorectal carcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Colonic Diseases / diagnosis. Colonic Neoplasms / diagnosis. Colonography, Computed Tomographic. Colonoscopy. Constipation / etiology. Diarrhea / etiology. Intestinal Obstruction / diagnosis. Video Recording
  • [MeSH-minor] Aged. Colon / pathology. Diagnostic Errors. Humans. Male. Neoplasm Staging


26. Miyamoto H, Yoshida S, Imatomi M, Saitoh T, Nakata A: [Successful treatment of advanced recurent breast cancer using DMpC therapy as maintenance therapy]. Gan To Kagaku Ryoho; 2002 Mar;29(3):427-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Successful treatment of advanced recurent breast cancer using DMpC therapy as maintenance therapy].
  • A 65-year-old female who underwent radical mastectomy on 28 April 1988 felt swelling and numbness of her left lower jaw.
  • After 6 cycles of CMF therapy, the swelling and numbness of the left lower jaw were reduced, but atelectasis of the left lung upper lobe appeared.
  • After 10 cycles of paclitaxel therapy, atelectasis and bone metastasis were reduced.
  • Daily oral chemoendocrine combination therapy, DMpC therapy (5'-DFUR 800 mg/day + CPA 100 mg/day + MPA 800 mg/day) was continued for 12 months.
  • No recurrent signs and serious side effects were observed during DMpC therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / drug therapy. Neoplasm Recurrence, Local / drug therapy
  • [MeSH-minor] Aged. Bone Neoplasms / secondary. Cyclophosphamide / administration & dosage. Drug Administration Schedule. Female. Floxuridine / administration & dosage. Humans. Medroxyprogesterone Acetate / administration & dosage

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  • (PMID = 11915733.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 039LU44I5M / Floxuridine; 8N3DW7272P / Cyclophosphamide; C2QI4IOI2G / Medroxyprogesterone Acetate; V1JK16Y2JP / doxifluridine
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