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1. Schneeberger S, Kreczy A, Brandacher G, Steurer W, Margreiter R: Steroid- and ATG-resistant rejection after double forearm transplantation responds to Campath-1H. Am J Transplant; 2004 Aug;4(8):1372-4
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  • [Title] Steroid- and ATG-resistant rejection after double forearm transplantation responds to Campath-1H.
  • We herein report on immunological and histological observations in the first bilateral forearm transplant recipient.
  • The last of three rejection episodes occurring on day 95 after transplantation was resistant to steroid and antithymocyte globulin (ATG) treatment.
  • Therapy with Campath-1H, however, resulted in complete restitution of normal skin.
  • This is the first report on a successful rescue therapy with Campath-1H in a severe, steroid- and ATG-resistant rejection.
  • Hence, Campath-1H treatment might be a novel and powerful therapeutic option for multiresistant allograft rejection.
  • [MeSH-major] Antibodies, Monoclonal / pharmacology. Antibodies, Neoplasm / pharmacology. Antilymphocyte Serum / pharmacology. Drug Resistance. Forearm / pathology. Graft Rejection. Immunosuppressive Agents / therapeutic use. Organ Transplantation / methods. Steroids / pharmacology. Transplantation, Homologous / methods
  • [MeSH-minor] Adult. Antibodies, Monoclonal, Humanized. Antineoplastic Agents / pharmacology. Epidermis / pathology. Humans. Keratinocytes / pathology. Lymphocytes / pathology. Male. Necrosis. Skin / pathology. Skin Transplantation / methods. Time Factors

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  • (PMID = 15268743.001).
  • [ISSN] 1600-6135
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antibodies, Neoplasm; 0 / Antilymphocyte Serum; 0 / Antineoplastic Agents; 0 / Immunosuppressive Agents; 0 / Steroids; 3A189DH42V / alemtuzumab
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2. Einspahr JG, Xu MJ, Warneke J, Saboda K, Ranger-Moore J, Bozzo P, Duckett L, Goldman R, Lin P, Buckmeier J, Alberts DS: Reproducibility and expression of skin biomarkers in sun-damaged skin and actinic keratoses. Cancer Epidemiol Biomarkers Prev; 2006 Oct;15(10):1841-8
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  • There was a stepwise increase in putrescine and spermidine in normal, sun-damaged forearm, forearm from subjects with AK, and the AK lesion itself (P < 0.0001).
  • [MeSH-major] Biomarkers / metabolism. Keratosis / etiology. Keratosis / metabolism. Proliferating Cell Nuclear Antigen / biosynthesis. Sunscreening Agents / therapeutic use. Tumor Suppressor Protein p53 / biosynthesis. Ultraviolet Rays / adverse effects
  • [MeSH-minor] Adult. Aged. Biogenic Polyamines / metabolism. Biogenic Polyamines / radiation effects. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Female. Forearm / pathology. Forearm / radiation effects. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Neoplasms, Radiation-Induced / drug therapy. Neoplasms, Radiation-Induced / metabolism. Neoplasms, Radiation-Induced / pathology. Precancerous Conditions / drug therapy. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Reproducibility of Results. Skin Neoplasms / drug therapy. Skin Neoplasms / etiology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Treatment Outcome

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  • (PMID = 17021352.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA23074; United States / NCI NIH HHS / CA / CA27502
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biogenic Polyamines; 0 / Biomarkers; 0 / Proliferating Cell Nuclear Antigen; 0 / Sunscreening Agents; 0 / Tumor Suppressor Protein p53
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3. Shah JP, Gil Z: Current concepts in management of oral cancer--surgery. Oral Oncol; 2009 Apr-May;45(4-5):394-401
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  • Surgery is the most well established mode of initial definitive treatment for a majority of oral cancers.
  • The factors that affect choice of treatment are related to the tumor and the patient.
  • The radial forearm free flap provides excellent soft tissue and lining for soft tissue defects in the oral cavity.
  • Over the course of the past thirty years there has been improvement in the overall survival of patients with oral carcinoma largely due to the improved understanding of the biology of local progression, early identification and treatment of metastatic lymph nodes in the neck, and employment of adjuvant post-operative radiotherapy or chemoradiotherapy.
  • The role of surgery in primary squamous cell carcinomas in other sites in the head and neck has evolved with integration of multidisciplinary treatment approaches employing chemotherapy and radiotherapy either sequentially or concurrently.
  • Similarly, the role of the surgeon is essential throughout the life history of a patient with a malignant neoplasm in the head and neck area, from initial diagnosis through definitive treatment, post-treatment surveillance, management of complications, rehabilitation of the sequelae of treatment, and finally for palliation of symptoms.
  • [MeSH-minor] Antineoplastic Protocols. Bone Neoplasms / surgery. Combined Modality Therapy. Head and Neck Neoplasms / surgery. Humans. Patient Selection. Reconstructive Surgical Procedures. Skin Neoplasms / surgery. Skull Base Neoplasms / surgery. Soft Tissue Neoplasms / surgery. Surgical Flaps. Treatment Outcome


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4. Orui H, Yamakawa M, Ishikawa A, Tsuchiya T, Ogino T: Malignant intramuscular forearm tumor with overwhelming squamous element. Pathol Int; 2000 Jul;50(7):574-8
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  • [Title] Malignant intramuscular forearm tumor with overwhelming squamous element.
  • A case of a 19-year-old female patient with an intramuscular forearm tumor showing a histopathologically overwhelming squamous element is presented.
  • [MeSH-minor] Actins / analysis. Actins / genetics. Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Axilla. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Drug Therapy, Combination. Female. Forearm / pathology. Humans. Lymph Node Excision. Lymph Nodes / surgery. Magnetic Resonance Imaging. Mitomycin / administration & dosage. Oncogene Proteins, Fusion / analysis. Oncogene Proteins, Fusion / genetics. Peplomycin / administration & dosage. RNA, Messenger / metabolism. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 10886743.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] AUSTRALIA
  • [Chemical-registry-number] 0 / Actins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / SYT-SSX fusion protein; 50SG953SK6 / Mitomycin; 56H9L80NIZ / Peplomycin; 5J49Q6B70F / Vincristine; Q20Q21Q62J / Cisplatin
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5. Vetter M, Germann G, Bickert B, Sauerbier M: Current strategies for sarcoma reconstruction at the forearm and hand. J Reconstr Microsurg; 2010 Sep;26(7):455-60
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  • [Title] Current strategies for sarcoma reconstruction at the forearm and hand.
  • Multistructural reconstructive procedures are often required to achieve a sufficient reconstruction of the forearm and/or hand after radical tumor resection.
  • Clear margin (R0) resection is the main therapeutic goal for the treatment of sarcomas.
  • In our department, 20 patients with soft tissue sarcomas of the hand/forearm were treated between 1995 and 2005.
  • The average follow-up time was 42 months.
  • The most common tumor type was the myxoid fibrous histiocytoma in 10 cases.
  • Ten patients received radiation and four obtained chemotherapy postoperatively (two patients received neoadjuvant chemotherapy).
  • Our results show the necessity of plastic-surgical reconstruction of the forearm and hand as an integrative component of modern sarcoma therapy.
  • It can be concluded that plastic-surgical reconstruction of the extremity plays a key role within the multimodal concept of therapy for patients with sarcoma at the forearm and hand.
  • [MeSH-major] Forearm / surgery. Hand / surgery. Reconstructive Surgical Procedures / methods. Sarcoma / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Child. Child, Preschool. Combined Modality Therapy. Disability Evaluation. Female. Fibula / transplantation. Histiocytoma, Malignant Fibrous / pathology. Histiocytoma, Malignant Fibrous / surgery. Humans. Infant. Limb Salvage. Male. Microsurgery / methods. Middle Aged. Neoadjuvant Therapy. Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. Surveys and Questionnaires

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  • [Copyright] (c) Thieme Medical Publishers.
  • (PMID = 20458673.001).
  • [ISSN] 1098-8947
  • [Journal-full-title] Journal of reconstructive microsurgery
  • [ISO-abbreviation] J Reconstr Microsurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Müller M, Bickert B, Germann G, Sauerbier M: [Soft-tissue sarcoma of the forearm and hand. Plastic surgical management]. Chirurg; 2008 Jul;79(7):682-8
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  • [Title] [Soft-tissue sarcoma of the forearm and hand. Plastic surgical management].
  • Radical tumor resection (R0) is the main therapeutic goal in the treatment of sarcomas of the forearm and hand.
  • Sophisticated reconstructive techniques are required with the forearm and hand.
  • Twenty patients with soft-tissue sarcomas of the hand and forearm were treated in our department between January 1995 and January 2005.
  • Ten patients received radiation and four got chemotherapy (two with neoadjuvant chemotherapy).
  • The average follow-up-time was 42 months.
  • These results show the necessity of plastic surgical reconstruction of the forearm and hand as an integral component of modern sarcoma therapy.
  • Multidisciplinary cooperation is mandatory for adequate treatment.
  • [MeSH-major] Forearm / surgery. Hand / surgery. Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Infant. Limb Salvage. Male. Microsurgery. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Surgical Flaps

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  • (PMID = 18437325.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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7. Hoshi M, Takami M, Ieguchi M: Pleomorphic malignant fibrous histiocytoma: response of bone, lung, and brain metastases to chemotherapy. Radiat Med; 2008 Oct;26(8):499-503
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  • [Title] Pleomorphic malignant fibrous histiocytoma: response of bone, lung, and brain metastases to chemotherapy.
  • We present a case of pleomorphic malignant fibrous histiocytoma arising from the left forearm in a 45-year-old man who had undergone resection and radiotherapy for a tumor 3 years previously.
  • Although these metastases responded well to systemic chemotherapy, brain metastases newly appeared and caused the death of the patient.
  • These findings demonstrate that individual sarcomatous metastatic organs exhibit different sensitivities to chemotherapy.
  • It is suggested that the blood-brain barrier may play an important role in sensitivity to chemotherapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Brain Neoplasms / drug therapy. Histiocytoma, Malignant Fibrous / drug therapy. Lung Neoplasms / drug therapy. Neoplasm Recurrence, Local
  • [MeSH-minor] Acetabulum. Bone and Bones / drug effects. Brain / drug effects. Doxorubicin / administration & dosage. Forearm. Humans. Ifosfamide / administration & dosage. Lung / drug effects. Male. Middle Aged


8. Andrades P, Pehler SF, Baranano CF, Magnuson JS, Carroll WR, Rosenthal EL: Fistula analysis after radial forearm free flap reconstruction of hypopharyngeal defects. Laryngoscope; 2008 Jul;118(7):1157-63
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  • [Title] Fistula analysis after radial forearm free flap reconstruction of hypopharyngeal defects.
  • OBJECTIVE/HYPOTHESIS: To evaluate risk factors and management options for fistula formation after hypopharyngeal reconstruction using the radial forearm free flap reconstruction.
  • METHODS: Patients undergoing radial forearm free flap for hypopharyngeal reconstruction were retrospectively reviewed.
  • A total of 104 patients underwent this procedure between 2001 and 2007.
  • RESULTS: Pharyngocutaneous fistula developed in 30 (28.8%) patients.
  • Recurrence, cancer stage, cancer location, type of ablative surgery, and the addition of other oncologic procedures were identified as significant predictors of fistula formation.
  • One third of the cases responded to conservative management, and 20 cases required a surgical procedure to definitively close the fistulous track.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Female. Graft Survival. Humans. Male. Middle Aged. Neck Dissection. Neoadjuvant Therapy. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Prognosis. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Risk Factors

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  • (PMID = 18438265.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Leit ME, Tomaino MM: Principles of limb salvage surgery of the upper extremity. Hand Clin; 2004 May;20(2):v, 167-79
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  • Historically, amputation was the treatment of choice for a neoplasm of the hand, wrist, and forearm, but limb-sparing procedures have become feasible largely because of advances in diagnostic imaging, reconstructive microsurgery, and adjuvant radiotherapy and chemotherapy.
  • [MeSH-major] Bone Neoplasms / surgery. Limb Salvage. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Bone Transplantation. Fibula / transplantation. Forearm. Giant Cell Tumor of Bone / surgery. Hand. Humans. Prostheses and Implants. Surgical Flaps

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  • (PMID = 15201022.001).
  • [ISSN] 0749-0712
  • [Journal-full-title] Hand clinics
  • [ISO-abbreviation] Hand Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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10. Banga R, Ramsden J, Cox G: Recurrent squamous cell carcinoma in the neopharynx treated successfully with topical 5-fluorouracil. J Laryngol Otol; 2005 May;119(5):403-4
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  • We present the first reported case of a squamous cell carcinoma recurrence on a reconstructed flap in the pharynx treated successfully with topical chemotherapy.
  • The patient, treated for a pharyngeal cancer with resection and reconstruction with a free radial forearm flap, and post-operative radiotherapy, developed a tumour on the flap more than two years after surgery.
  • The patient was alive and well more than 28 months after this treatment, with no sign of disease recurrence.
  • Topical chemotherapy for treatment of oral cancer is well described for early disease, but we show that it may be a useful treatment in recurrent disease in selected patients.
  • [MeSH-major] Antimetabolites, Antineoplastic / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Fluorouracil / administration & dosage. Pharyngeal Neoplasms / drug therapy
  • [MeSH-minor] Administration, Topical. Aged. Humans. Male. Neoplasm Recurrence, Local. Treatment Outcome

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  • (PMID = 15949109.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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11. Pierlot A, Calteux N, Mataigne F, Colette JM: [Soft tissue sarcomas of the hand: report of a radiation-induced case]. Ann Chir Plast Esthet; 2001 Feb;46(1):45-54
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  • [Title] [Soft tissue sarcomas of the hand: report of a radiation-induced case].
  • [Transliterated title] Les sarcomes des tissus mous de la main. A propos d'un cas de sarcome radio-induit.
  • Soft tissue sarcoma surgery is based on techniques that are in the process of ongoing development.
  • In this study, the case is reported of a female patient who was operated on at the age of 14 years for a primary synoviosarcoma of the dominant hand, which was treated by conservative surgery and 60 Gy adjuvant radiotherapy.
  • Amputation of the distal third of the forearm was performed.
  • Two main factors should be taken into account in treatment strategy: i) distant metastases of high-grade soft tissue sarcomas often appear early in the course of the disease, and are not affected by surgery at the primary site;.
  • Technical progress and a multidisciplinary approach have resulted in more sophisticated treatment (allowing a larger surgical resection area, and better residual function).
  • Surgical management remains the treatment of choice, as radiotherapy and chemotherapy have not demonstrated any positive effect on patient survival.
  • [MeSH-major] Forearm. Hand. Histiocytoma, Benign Fibrous / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Sarcoma, Synovial / radiotherapy. Soft Tissue Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Amputation. Biopsy. Female. Humans. Magnetic Resonance Imaging. Neoplasm Staging. Survival Analysis. Tomography, X-Ray Computed

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  • (PMID = 11233734.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 79
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12. Kayton ML, Meyers P, Wexler LH, Gerald WL, LaQuaglia MP: Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults. J Pediatr Surg; 2006 Jan;41(1):187-93
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  • [Title] Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults.
  • PURPOSE: Alveolar soft part sarcoma is a rare soft tissue neoplasm that can affect children and adolescents.
  • To define the clinical presentation, treatment, and outcome of young people with this rare sarcoma, we reviewed our clinical experience.
  • METHODS: After institutional review board approval, we examined the records of all patients younger than 25 years old who received treatment at our institution for alveolar soft part sarcoma in the past 30 years.
  • Demographics, tumor sizes, sites and extent of disease, treatments used, progression-free survival, and overall follow-up were evaluated.
  • Primary disease sites were thigh (n = 8), trunk (n = 6), retroperitoneum (n = 2), and scalp, neck, forearm, and calf (n = 1 each).
  • Chemotherapy was used in 11 patients; radiation was used in 8.
  • We found an association between smaller tumor size and longer time to progression.
  • We were not able to demonstrate any benefit from chemotherapy or radiation.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Disease Progression. Embolization, Therapeutic. Female. Follow-Up Studies. Humans. Male. Neoplasm Metastasis. Retrospective Studies. Survival Analysis. Treatment Outcome


13. Paramo JC, Benavides C, Tang LW, Martinez A, Cabello-Inchausti B, Davila E, Mesko TW: Complete remission of previously intractable peripheral cutaneous T-cell lymphoma of the lower extremity using isolated hyperthermic limb perfusion with melphalan (1-phenylalanine mustard). Cancer Invest; 2004;22(4):545-9
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  • Initially she presented with subcutaneous indurated areas in the right forearm, scapula, and submadibular region.
  • After chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), she went into remission for 2 years before relapse of her PCTCL localized to the right lower extremity.
  • Persistent isolated disease in the extremity since then led to numerous chemotherapy regimens and localized radiation therapy.
  • Although limb preservation could not be achieved, this treatment resulted in complete clinical and pathological regression of the lesions of the perfused extremity.
  • [MeSH-major] Antineoplastic Agents, Alkylating / administration & dosage. Hyperthermia, Induced / methods. Lower Extremity. Lymphoma, T-Cell, Cutaneous / therapy. Melphalan / administration & dosage. Skin Neoplasms / therapy
  • [MeSH-minor] Aged. Amputation. Chemotherapy, Cancer, Regional Perfusion. Combined Modality Therapy. Female. Humans. Neoplasm Metastasis. Neoplasm Recurrence, Local


14. Papanastassiou I, Ioannou M, Magoulas D, Lalos S, Athanassiou AE, Ziras N, Thanopoulou E, Demertzis N: Chemoembolization facilitates limb salvage surgery in stage III soft tissue sarcoma. J BUON; 2009 Jul-Sep;14(3):507-10
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  • [Title] Chemoembolization facilitates limb salvage surgery in stage III soft tissue sarcoma.
  • A 26 year-old male was referred to our unit because of a stage III soft tissue sarcoma in the shoulder girdle-axillary area and reduced forearm-distal arm strength.
  • The patient received adjuvant chemotherapy (ifosfamide/mesna, adriamycin, and dacarbazine/MAID) and finally radiation therapy (RT; 6500 cGy total dose).
  • In stage III soft tissue sarcomas, especially in proximity with major nerve/arterial bundles, a multimodality approach is mandatory; chemoembolization is very effective in shrinking the tumor and defining its margins so as to make feasible a LSS.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Embolization, Therapeutic. Limb Salvage. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Adult. Antibiotics, Antineoplastic / therapeutic use. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Agents, Phytogenic / therapeutic use. Chemotherapy, Adjuvant. Cyclophosphamide / therapeutic use. Doxorubicin / therapeutic use. Humans. Male. Neoplasm Staging. Radiotherapy, Adjuvant. Vincristine / therapeutic use

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  • (PMID = 19810146.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Phytogenic; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide
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15. Siebenrock KA, Hertel R, Ganz R: Unexpected resection of soft-tissue sarcoma. More mutilating surgery, higher local recurrence rates, and obscure prognosis as consequences of improper surgery. Arch Orthop Trauma Surg; 2000;120(1-2):65-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unexpected resection of soft-tissue sarcoma. More mutilating surgery, higher local recurrence rates, and obscure prognosis as consequences of improper surgery.
  • Sixteen referred patients were reviewed after excision of an unexpected soft-tissue sarcoma of the extremities.
  • Four patients received adjuvant local radiation, with additional chemotherapy in 2 of them.
  • At an average follow-up of 4.5 years (range 15-149 months), 4 patients (25%) had developed distant metastases with a local recurrence in 3 (19%).
  • Evaluation by adequate imaging techniques, biopsy, and definitive resection and reconstruction should be performed by an oncologically trained orthopaedic surgeon.
  • [MeSH-major] Sarcoma / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Amputation. Chemotherapy, Adjuvant. Female. Forearm. Humans. Leg. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Radiotherapy, Adjuvant. Reoperation. Shoulder

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  • (PMID = 10653107.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY
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16. Germain MA, Bonvalot S, Rimareix F, Missana CM: [Locally advanced soft-tissue sarcomas. An innovating triad to avoid amputation: isolated limb perfusion, TNFalpha, and free microsurgical flap]. Bull Acad Natl Med; 2010 Jan;194(1):51-65; discussion 65-7
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  • [Title] [Locally advanced soft-tissue sarcomas. An innovating triad to avoid amputation: isolated limb perfusion, TNFalpha, and free microsurgical flap].
  • [Transliterated title] Sauvetage des membres atteints de sarcome localement evolué. La triade innovante: perfusion de membre isole sous CEC, TNFalpha, et transplant microchirurgical.
  • We retrospectively studied the benefits of isolated limb perfusion combined with TNFalpha administration and free flap reconstruction in locally advanced soft-tissue sarcomas of the limbs.
  • Between 2000 and 2008, we treated 37 patients (22 women and 15 men) with locally advanced soft tissue sarcomas.
  • Seventeen patients received neoadjuvant chemotherapy.
  • Sarcoma excision was combined with a complementary procedure in 10 patients (vascular graft or nerve anastomosis).
  • Reconstruction was performed with free flaps of the latissimus dorsi (n = 31), transverse rectus abdominis myocutaneous flaps (n = 4) or free forearm flaps (n = 2).
  • The procedure lasted a median of 7 hours.
  • Thirteen patients developed pulmonary metastases and seven of them died between the first and fifth years of follow-up.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Cancer, Regional Perfusion. Extremities / surgery. Sarcoma / drug therapy. Sarcoma / surgery. Soft Tissue Neoplasms / drug therapy. Soft Tissue Neoplasms / surgery. Tumor Necrosis Factor-alpha / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Lung Neoplasms / mortality. Lung Neoplasms / secondary. Male. Middle Aged. Muscle, Skeletal / transplantation. Neoadjuvant Therapy. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / surgery. Neoplasms, Radiation-Induced / drug therapy. Neoplasms, Radiation-Induced / surgery. Neoplasms, Second Primary / drug therapy. Neoplasms, Second Primary / surgery. Radiotherapy, Adjuvant. Reconstructive Surgical Procedures. Reoperation. Retrospective Studies. Skin Transplantation. Surgical Flaps. Treatment Outcome. Young Adult

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  • (PMID = 20669559.001).
  • [ISSN] 0001-4079
  • [Journal-full-title] Bulletin de l'Académie nationale de médecine
  • [ISO-abbreviation] Bull. Acad. Natl. Med.
  • [Language] fre
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha
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17. Mentzel T, Kuhnen C: Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch; 2006 Nov;449(5):554-60
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  • Four neoplasms arose on the lower extremities and one case each on the forearm, the lateral aspect of the neck and the penis.
  • Five neoplasms were completely excised, in one incompletely excised neoplasm additional chemotherapy was given, and in one patient a biopsy was done only so far.
  • All neoplasms arose in subcutaneous and deep soft tissues with dermal involvement in one case, and the size of the neoplasms ranged from 4 to 19 cm in largest diameter.
  • In summary, spindle cell rhabdomyosarcoma represents a rare neoplasm in adulthood characterized clinically by a rather poor prognosis, and shows a broad morphological spectrum including most likely the sclerosing, pseudovascular variant.
  • [MeSH-major] Rhabdomyosarcoma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • [Cites] Cancer. 2003 Aug 1;98(3):571-80 [12879475.001]
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  • (PMID = 17013628.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD99; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules
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18. Gurney TA, Eisele DW, Orloff LA, Wang SJ: Predictors of quality of life after treatment for oral cavity and oropharyngeal carcinoma. Otolaryngol Head Neck Surg; 2008 Aug;139(2):262-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictors of quality of life after treatment for oral cavity and oropharyngeal carcinoma.
  • BACKGROUND: Treatment for head and neck cancer, including surgery, radiation, and chemotherapy, can impact quality of life.
  • Eighteen percent had free-tissue transfer (fibula free flap in 8% and radial forearm free flap in 10%).
  • CONCLUSION: Stage, gastrostomy-tube dependence, complication, recurrence, and treatment modality influence quality of life.
  • A better understanding of the impact of oral cavity and oropharyngeal cancer treatment on quality of life will enable us to better advise our patients.
  • [MeSH-major] Mouth Neoplasms / therapy. Pharyngeal Neoplasms / therapy. Quality of Life
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Predictive Value of Tests. Regression Analysis. Surgical Flaps. Surveys and Questionnaires. Treatment Outcome

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  • (PMID = 18656726.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Stage AC, Pollock RE, Matin SF: Bilateral metastatic renal synovial sarcoma. Urology; 2005 Feb;65(2):389
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  • Synovial sarcoma is a malignant soft-tissue neoplasm, usually arising in close association with the joints and generally carrying a poor prognosis.
  • Treatment consisted of systemic therapy with bilateral partial nephrectomies.
  • [MeSH-major] Forearm. Kidney Neoplasms / secondary. Sarcoma, Synovial / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Amputation. Antineoplastic Agents, Alkylating / therapeutic use. Combined Modality Therapy. Female. Humans. Ifosfamide / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Middle Aged. Nephrectomy / methods

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  • (PMID = 15708068.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; UM20QQM95Y / Ifosfamide
  • [Number-of-references] 3
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20. Hirano S, Tateya I, Kitamura M, Kada S, Ishikawa S, Kanda T, Tanaka S, Ito J: Organ preservation surgery for advanced hypopharyngeal cancer. Acta Otolaryngol Suppl; 2010 Nov;(563):50-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSION: Organ preservation surgery with partial pharyngectomy preserving the larynx is feasible for the treatment of advanced hypopharyngeal cancer with comparable local control and preservation of function.
  • OBJECTIVES: To examine the feasibility and therapeutic effects of organ preservation surgery for advanced hypopharyngeal cancer.
  • Reconstruction of the pharyngolarynx was completed by primary mucosal suture in six, while free forearm flap was used in eight cases.
  • Induction chemotherapy was administered for six cases including three with T3/4 tumors.
  • [MeSH-major] Hypopharyngeal Neoplasms / therapy. Pharyngectomy
  • [MeSH-minor] Aged. Cohort Studies. Combined Modality Therapy. Female. Humans. Laryngectomy. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Retrospective Studies. Surgical Flaps. Survival Rate. Treatment Outcome

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  • (PMID = 20879819.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Disa JJ, Pusic AL, Hidalgo DA, Cordeiro PG: Microvascular reconstruction of the hypopharynx: defect classification, treatment algorithm, and functional outcome based on 165 consecutive cases. Plast Reconstr Surg; 2003 Feb;111(2):652-60; discussion 661-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microvascular reconstruction of the hypopharynx: defect classification, treatment algorithm, and functional outcome based on 165 consecutive cases.
  • Partial defects were reconstructed with radial forearm flaps (n = 52); circumferential defects were reconstructed with jejunum (n = 90); and extensive, noncircumferential longitudinal defects were reconstructed with rectus abdominis flaps (n = 23).
  • The treatment algorithm for microvascular hypopharyngeal reconstruction is based on the type of defect with partial defects with radial forearm flaps, circumferential defects reconstructed with free jejunal flaps, and extensive, multilevel defects reconstructed with rectus abdominis myocutaneous flaps.
  • [MeSH-major] Hypopharyngeal Neoplasms / surgery. Microsurgery / methods. Neoplasm Recurrence, Local / surgery. Surgical Flaps / blood supply
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Algorithms. Female. Humans. Male. Microcirculation / surgery. Middle Aged. Neoadjuvant Therapy. Postoperative Complications / etiology. Postoperative Complications / surgery. Reoperation. Risk Factors. Tissue Survival / drug effects. Tissue Survival / radiation effects

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  • [CommentIn] Plast Reconstr Surg. 2004 Feb;113(2):775; author reply 775-6 [14758269.001]
  • (PMID = 12560686.001).
  • [ISSN] 0032-1052
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Nakai N, Katoh N, Germeraad WT, Kishida T, Ueda E, Takenaka H, Mazda O, Kishimoto S: Immunohistological analysis of peptide-induced delayed-type hypersensitivity in advanced melanoma patients treated with melanoma antigen-pulsed mature monocyte-derived dendritic cell vaccination. J Dermatol Sci; 2009 Jan;53(1):40-7
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  • [Title] Immunohistological analysis of peptide-induced delayed-type hypersensitivity in advanced melanoma patients treated with melanoma antigen-pulsed mature monocyte-derived dendritic cell vaccination.
  • BACKGROUND: In melanoma patients vaccinated with monocyte-derived melanoma peptide-pulsed dendritic cells (DC), the delayed-type hypersensitivity (DTH) reactions have been examined as a surrogate marker to determine if acquired immunity is induced by DC vaccination.
  • METHODS: Seven patients previously vaccinated with monocyte-derived melanoma peptide-pulsed DCs were challenged with recall antigenic peptide injection in the skin of the forearm.
  • Using immunohistochemical techniques, the presence of immune cells and the expression of CD4, CD8, interleukin (IL)-2, IL-4, IL-10, Foxp3, CD1a, CD1d, and interferon (IFN)-gamma was investigated at the site of injection where a DTH reaction developed.
  • Biopsies taken from the DTH site revealed heavy infiltration of mononuclear cells and eosinophils in the dermis and subcutaneous tissue.
  • CONCLUSIONS: The significant induction of CD8(+)T cells as well as both Th1 and Th2-type cells at the site of DTH suggests that effective antigen presentation leading to anti-tumor immune responses has taken place.
  • [MeSH-major] Antigens, Neoplasm / therapeutic use. Cancer Vaccines / therapeutic use. Hypersensitivity, Delayed / pathology. Langerhans Cells / pathology. Melanoma / drug therapy. Skin Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antigen Presentation / immunology. Biopsy. CD8-Positive T-Lymphocytes / immunology. CD8-Positive T-Lymphocytes / pathology. Female. Humans. Male. Middle Aged. Skin / pathology. Th1 Cells / immunology. Th1 Cells / pathology. Th2 Cells / immunology. Th2 Cells / pathology. Time Factors

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  • (PMID = 18804963.001).
  • [ISSN] 0923-1811
  • [Journal-full-title] Journal of dermatological science
  • [ISO-abbreviation] J. Dermatol. Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cancer Vaccines
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23. Baliski CR, Temple WJ, Arthur K, Schachar NS: Desmoid tumors: a novel approach for local control. J Surg Oncol; 2002 Jun;80(2):96-9
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  • Although this is an unusual problem, we instituted a prospective cohort study with neoadjuvant chemotherapy and radiation, followed by surgical resection, in an effort to improve local control.
  • METHODS: Between 1985 and 1999, 13 patients with potentially resectable disease were managed with a treatment protocol of preoperative doxorubicin (30 mg continuous infusion daily for 3 days) and radiotherapy (10 x 300 cGy).
  • In one patient with a chest wall tumor, two new primary desmoid tumors developed outside the treatment area, in the ipsilateral arm and forearm.
  • Neoadjuvant treatment with doxorubicin and radiotherapy appears to be a better option than surgery alone, or surgery and adjuvant radiotherapy.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Doxorubicin / administration & dosage. Fibromatosis, Abdominal / therapy. Neoplasm Recurrence, Local / prevention & control
  • [MeSH-minor] Adolescent. Adult. Cohort Studies. Humans. Middle Aged. Neoadjuvant Therapy. Prospective Studies

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  • (PMID = 12173387.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin
  • [Number-of-references] 23
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