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1. Johnson SB, Eng TY, Giaccone G, Thomas CR Jr: Thymoma: update for the new millennium. Oncologist; 2001;6(3):239-46
MedlinePlus Health Information. consumer health - Thymus Cancer.

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  • Thymomas are relatively common tumors of the anterior superior mediastinum.
  • They are usually relatively slowly growing tumors and their prognosis depends on the macroscopic and microscopic invasion of surrounding tissues.
  • Surgery is the mainstay treatment of thymomas, and complete resection represents one of the most important prognostic factors in this disease.
  • Postoperative radiotherapy is indicated in tumors with invasion of surrounding tissues, even if resection was radical, since it improves local control and survival.
  • Cytotoxic chemotherapy has been employed in several relatively small phase II studies and in advanced disease has been demonstrated to produce a 50%-80% objective response rate.
  • Neoadjuvant cytotoxic chemotherapy and/or external beam radiotherapy has been used with some success in patients with tumors which are not readily resectable.
  • [MeSH-major] Thymoma / pathology. Thymoma / therapy. Thymus Neoplasms / pathology. Thymus Neoplasms / therapy
  • [MeSH-minor] Humans. Neoplasm Staging. Prognosis

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  • (PMID = 11423670.001).
  • [ISSN] 1083-7159
  • [Journal-full-title] The oncologist
  • [ISO-abbreviation] Oncologist
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA54174
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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2. Fujiwara K, Segawa Y, Takigawa N, Kishino D, Ida M, Eguchi K, Nakata M, Saeki H, Mandai K: Two cases of atypical carcinoid of the thymus. Intern Med; 2000 Oct;39(10):834-8
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  • Computed tomography scans of the chest in both cases revealed a large mass in the anterior mediastinum.
  • Combination chemotherapy consisting of carboplatin and etoposide was performed as initial chemotherapy in the former case and as adjuvant therapy in the latter.
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Chromogranin A. Chromogranins / analysis. Female. Humans. Immunoenzyme Techniques. Middle Aged. Neoplasm Proteins / analysis. Phosphopyruvate Hydratase / analysis. Synaptophysin / analysis. Tomography, X-Ray Computed

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  • (PMID = 11030210.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Chromogranins; 0 / Neoplasm Proteins; 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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3. Kondo K: Optimal therapy for thymoma. J Med Invest; 2008 Feb;55(1-2):17-28
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  • [Title] Optimal therapy for thymoma.
  • Thymoma is the most common tumor of the anterior mediastinum.
  • The rarity of this tumor has somewhat obscured the optimal treatment.
  • The optimal treatment for thymoma depends on its clinical stage.
  • Surgery remains the mainstay of treatment for thymic epithelial tumors.
  • Thymomas also have a high response rate to chemotherapy or radiotherapy.
  • Multimodality therapy involving surgery, chemotherapy and radiotherapy appears to increase the rate of complete resection and survival in advanced (stage III and IV) thymomas.
  • [MeSH-major] Thymoma / therapy. Thymus Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Chemotherapy, Adjuvant. Cisplatin / therapeutic use. Combined Modality Therapy. Humans. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Thymectomy. World Health Organization

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  • (PMID = 18319541.001).
  • [ISSN] 1343-1420
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 75
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4. Traficante D, Longo F, Mansueto G, Salerno M, Scirocchi R, De Petris L, Marchei P: [Combined treatment of thymoma. State of the art and our experience]. Recenti Prog Med; 2000 Oct;91(10):513-6
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  • [Title] [Combined treatment of thymoma. State of the art and our experience].
  • [Transliterated title] Trattamento integrato del timoma. Stato dell'arte e nostra esperienza.
  • Thymoma is the most common neoplasm of the anterior mediastinum and is frequently associated with paraneoplastic syndromes.
  • Surgery is the first therapeutic option, but in advanced disease a multidisciplinary approach is feasible, because of chemosensitivity and radiosensitivity of the disease.
  • Chemotherapy based on cisplatin plus anthracyclines could be performed in advanced and metastatic disease.
  • The optimal sequence of chemotherapy, radiation therapy and surgery is yet to be defined.
  • In our experience, primary chemotherapy seems to give best results in advanced thymoma with good tolerability.
  • [MeSH-major] Thymoma / therapy. Thymus Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Humans. Neoplasm Staging. Radiotherapy. Thymectomy

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  • (PMID = 11072740.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Editorial; English Abstract; Review
  • [Publication-country] ITALY
  • [Number-of-references] 24
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5. Washino S, Terauchi F, Matsuzaki A, Kobayashi Y: [Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia]. Nihon Hinyokika Gakkai Zasshi; 2008 Sep;99(6):703-8
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  • Although chemotherapy of cisplatin and 5-fluorouracil with radiotherapy was effective, thereafter recurrence was occurred in renal pelvis, and the patient died 17 months after the initiation of therapy.
  • Case 2; a 54 year old male of primary SCC of right renal pelvis with local lymphadenopathy and anterior mediastinal metastases showed marked hypercalcemia.
  • Although the patient was administered UFT with palliative radiotherapy to the anterior mediastinum, he died 2 months after the initiation of therapy.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / administration & dosage. Combined Modality Therapy. Fatal Outcome. Female. Fluorouracil / administration & dosage. Granulocyte Colony-Stimulating Factor / biosynthesis. Granulocyte Colony-Stimulating Factor / blood. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Parathyroid Hormone-Related Protein / biosynthesis. Parathyroid Hormone-Related Protein / blood. Radiotherapy. Tegafur / administration & dosage. Uracil / administration & dosage

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  • (PMID = 18939454.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; 1-UFT protocol
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6. Valente M, Schinzari G, Ricciotti A, Barone C: Role of chemotherapy in malignant thymoma. Ann Ital Chir; 2007 Sep-Oct;78(5):377-80
MedlinePlus Health Information. consumer health - Thymus Cancer.

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  • [Title] Role of chemotherapy in malignant thymoma.
  • Thymomas and thymic carcinomas, which are rare epithelial tumors arising from the thymus gland, are the most common tumors of the anterior mediastinum.
  • Surgery is the principal treatment and is curative in early stage disease.
  • Radiation therapy, either alone or in combination with chemotherapy, may be an option both in not completely and completely resected disease.
  • Chemotherapy is offered to patients with locally advanced or metastatic thymoma and induces excellent responses race and prolonged survival.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Thymoma / drug therapy. Thymus Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 18338542.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 26
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7. Vassiliou V, Tsamandas A, Katodritis N, Charoulis N, Koukouma A, Andreopoulos D, Salakou S, Zolota V, Papathanassopoulos P, Christodoulides G, Dougenis D, Kardamakis D: The role of postoperative radiotherapy in the management of patients with thymic tumors -- a retrospective study. In Vivo; 2009 Sep-Oct;23(5):843-52
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  • BACKGROUND: Thymomas are the most common tumor arising in the anterior mediastinum.
  • RESULTS: DFS (disease free survival), TS (total survival) and DSS (disease specific survival) differed significantly between stages and histological types (p<0.04).
  • Stage III (n=8) and IV (n=8) patients underwent postoperative radiotherapy, with 4/8 of stage IV disease also receiving induction chemotherapy.
  • Six out of 8 stage III-IV patients recurred (1 distant and 5 intrathoracic failure), out of whom 4 died due to disease progression despite further treatment (all type C histology).
  • [MeSH-major] Thymoma / therapy. Thymus Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Greece / epidemiology. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 19779122.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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8. Yang GC, Yee HT, Wu CD, Aye LM, Chachoua A: TIA-1+ cytotoxic large T-cell lymphoma of the mediastinum: case report. Diagn Cytopathol; 2002 Mar;26(3):154-7
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  • [Title] TIA-1+ cytotoxic large T-cell lymphoma of the mediastinum: case report.
  • A 52-year-old previously healthy Caucasian woman presented with superior vena cava syndrome, secondary to compression of a bulky anterior mediastinal mass involving the right lung.
  • Fine-needle aspiration biopsy of the mediastinum yielded large epithelioid cells intermingled with small mature lymphocytes.
  • The patient responded well to six cycles of CHOP chemotherapy, followed by radiation with a total dose of 4140 cGy delivered to the mediastinum in 23 fractions.
  • To the best of our knowledge, this case may be the first report of cytotoxic large T-cell lymphoma of the mediastinum.
  • [MeSH-minor] Biopsy, Needle. Cytoplasmic Granules / chemistry. Cytoplasmic Granules / metabolism. Cytoplasmic Granules / ultrastructure. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Poly(A)-Binding Proteins

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  • [Copyright] Copyright 2002 Wiley-Liss, Inc.
  • (PMID = 11892019.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / Poly(A)-Binding Proteins; 0 / Proteins; 0 / RNA-Binding Proteins; 0 / TIA1 protein, human
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9. Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti M, De Rosa G, Colao A, Contegiacomo A: Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: response to chemotherapy and octreotide LAR. J Endocrinol Invest; 2005 Apr;28(4):371-8
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  • [Title] Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: response to chemotherapy and octreotide LAR.
  • Neuroendocrine tumors represent a heterogeneous category of neoplasm, with conflicting diagnostic and therapeutic demands.
  • In particular, a large ovarian mass, multinodular thyroid goiter, right adrenal mass, cystic liver metastases and anterior mediastinum lymph node metastasis were present.
  • Diagnosis of poorly differentiated metastasized NEC of unknown origin was made on the basis of histological and immunohistochemical findings, and treatment with etoposide (100 mg/m2 in days 1, 2 and 3) and cisplatinum (45 mg/m2 in days 2 and 3) was initiated.
  • Rapid improvement of dyspnea and a reduction of the largest thyroid nodule, liver metastases and adrenal mass by 50% were observed after 3 months of treatment; the dimensions remained stable thereafter, while the pericardial lymph node disappeared.
  • Our patient is alive 18 months after beginning the treatment, reporting good general condition and quality of life over the whole follow-up period.
  • [MeSH-major] Adrenal Gland Neoplasms / drug therapy. Antineoplastic Agents, Hormonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / drug therapy. Liver Neoplasms / secondary. Neoplasms, Unknown Primary / drug therapy. Neuroendocrine Tumors / drug therapy. Octreotide / therapeutic use. Ovarian Neoplasms / drug therapy
  • [MeSH-minor] Aged. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Treatment Outcome

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  • (PMID = 15966513.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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10. Michel M, Pratt JW: Anterior mediastinal nonseminomatous germ cell tumor with malignant transformation: a case report. Curr Surg; 2004 Nov-Dec;61(6):576-9
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  • [Title] Anterior mediastinal nonseminomatous germ cell tumor with malignant transformation: a case report.
  • OBJECTIVE: We report a case of a 21-year-old man who presented with the unusual symptoms of heart failure and was found to have an anterior mediastinal yolk sac tumor.
  • RESULTS: The patient was treated with the current standard of neoadjuvant chemotherapy: bleomycin, etoposide, and cisplatin (BEP) with marked reduction in tumor size, followed by en bloc surgical resection.
  • CONCLUSIONS: This is a rare initial presentation of an anterior mediastinal germ-cell tumor with treatment consisting of neoadjuvant therapy and surgical resection.
  • [MeSH-minor] Adult. Cell Transformation, Neoplastic / pathology. Heart Failure / etiology. Humans. Male. Mediastinum / pathology. Neoplasm Metastasis. Teratoma / pathology

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  • (PMID = 15590027.001).
  • [ISSN] 0149-7944
  • [Journal-full-title] Current surgery
  • [ISO-abbreviation] Curr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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11. Stremmel C, Passlick B: [Surgery of mediastinal tumors]. Chirurg; 2008 Jan;79(1):9-10, 12-7
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  • Thymomas, lymphomas, and germ cell tumors are the most frequent lesions of the anterior mediastinum, whereas endodermal (bronchogenic) cysts and lymphomas are the most frequent lesions of the middle mediastinum.
  • In the posterior mediastinum, neurogenic tumors and soft-tissue sarcomas are the most frequent.
  • Surgical treatment of thymoma is the gold standard, and median sternotomy is the most frequently applied approach.
  • The decisive prognostic and therapeutic criteria are Masaoka staging, WHO classification, and R0 status.
  • Surgical treatment is highly recommended in patients with locally recurrent tumors.
  • The importance of surgical treatment of germ cell tumors is determined by a negative concentration of beta-HCG and alpha-fetoprotein and in cases of residual tumor after chemotherapy.
  • Bronchogenic cysts always require resection because of their high complication rate (66%) after conservative treatment.
  • [MeSH-minor] Adult. Age Factors. Child. Female. Humans. Incidence. Male. Mediastinoscopy. Mediastinum / pathology. Neoplasm Staging. Prognosis. Radiography. Thoracoscopy. Thoracotomy

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  • (PMID = 18058077.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
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12. Billmire D, Vinocur C, Rescorla F, Colombani P, Cushing B, Hawkins E, London WB, Giller R, Lauer S: Malignant mediastinal germ cell tumors: an intergroup study. J Pediatr Surg; 2001 Jan;36(1):18-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: This review was conducted to determine clinical characteristics and response to therapy in this rare pediatric neoplasm.
  • METHODS: An intergroup Pediatric Oncology Group (POG) 9049/Children's Cancer Study Group (CCG) 8882 randomized trial was conducted to evaluate response rate and survival with chemotherapy using etoposide, bleomycin, and high or standard dose cisplatin for high-risk malignant germ cell tumors at extragonadal sites.
  • For this review, a secondary analysis of clinical and operative findings in patients with primary site in the mediastinum was carried out.
  • Thirty-four tumors were anterior mediastinal, 2 were intrapericardial.
  • Four patients had biopsy and chemotherapy without tumor resection, and only 1 survived.
  • Fourteen patients had resection at diagnosis followed by chemotherapy with 12 survivors.
  • Eighteen patients had biopsy followed by chemotherapy and postchemotherapy tumor resection with 13 survivors.
  • Tumor size in response to chemotherapy for these 18 patients was stable or increased in 6, and decreased in 12 (mean decrease of 57% in greatest dimension).
  • Lesions often have incomplete regression with chemotherapy alone.
  • Tumor resection may be undertaken at diagnosis or after attempted shrinkage with chemotherapy.
  • Aggressive attempt at complete tumor resection should be offered to all patients even if bulky tumor persists after induction chemotherapy with expectation of a significant salvage rate.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Mediastinal Neoplasms / drug therapy. Neoplasms, Germ Cell and Embryonal / drug therapy
  • [MeSH-minor] Adolescent. Biopsy. Bleomycin / administration & dosage. Child. Child, Preschool. Cisplatin / administration & dosage. Disease-Free Survival. Etoposide / administration & dosage. Female. Humans. Infant, Newborn. Male. Survival Rate. Treatment Outcome

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  • (PMID = 11150432.001).
  • [ISSN] 0022-3468
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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13. Graeber GM, Tamim W: Current status of the diagnosis and treatment of thymoma. Semin Thorac Cardiovasc Surg; 2000 Oct;12(4):268-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current status of the diagnosis and treatment of thymoma.
  • Although thymomas are rare neoplasms, they are the most common tumor of the anterior mediastinum in adults.
  • Preferred therapy for these neoplasms is complete surgical resection.
  • Significant 5- and 10-year survival rates have been recorded for patients with advanced thymomas who have been treated by radiation therapy alone.
  • Chemotherapy may be used in patients with unresectable thymomas as well, but the results are less promising than with radiotherapy.
  • Combinations of radiotherapy and chemotherapy used on patients with unresectable thymomas have produced encouraging results.
  • Surveillance of patients with thymoma should be prolonged because late recurrence (more than 5 years after initial therapy) can be expected in a significant minority of patients.
  • Aggressive therapy of late recurrence, including resection of new tumor masses and pleural metastases, has yielded successive disease-free intervals that validate persistent treatment.
  • [MeSH-minor] Humans. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / mortality. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / therapy. Neoplasm Staging

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  • [Copyright] Copyright 2000 by W.B. Saunders Company
  • (PMID = 11154722.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] UNITED STATES
  • [Number-of-references] 53
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14. Gripp S, Bölke E, Orth K: [Thymoma]. Wien Klin Wochenschr; 2005 Sep;117(18):620-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thymoma is a rare epithelial tumor of the thymus, but the most common malignancy in the anterior mediastinum.
  • According to the WHO classification 6 histologic types of thymic epithelial tumors can be discriminated.
  • Non-invasive tumors (stage I) are usually completely resected and no further therapy is warranted.
  • For incompletely resected tumors and locally advanced invasive thymomas (stage Ill-IV) postoperative radiotherapy with 50-60 Gy is advisable.
  • Chemotherapy, preferably with Cisplatinum, is indicated with inoperable thymomas or metastatic disease.
  • [MeSH-major] Drug Therapy / methods. Neoplasm Recurrence, Local / prevention & control. Radiotherapy / methods. Thymoma / diagnosis. Thymoma / therapy. Thymus Neoplasms / diagnosis. Thymus Neoplasms / therapy

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  • (PMID = 16416343.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 99
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15. Algalarrondo V, Misra SC, Bennani SL, Mabille M, Cavailloles F, Machover D, Slama MS: Ventricular tachycardia reveals cardiac infiltration due to mediastinal lymphoma. Europace; 2010 Sep;12(9):1344-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • After being treated by chemotherapy for a mediastinum lymphoplasmocytic lymphoma, a ventricular tachycardia (VT) occurred.
  • Several imaging techniques showed that this VT was related to a tumoural infiltration of the anterior part of the right ventricle by the lymphoma.
  • Ventricular arrhythmias were controlled under antiarrhythmic drugs and chemotherapy was continued, with close cardiac follow-up.
  • [MeSH-minor] Bundle-Branch Block / etiology. Electrocardiography. Heart Ventricles / pathology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Positron-Emission Tomography. Recurrence. Tachycardia, Ventricular / diagnosis. Tachycardia, Ventricular / etiology

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  • (PMID = 20484340.001).
  • [ISSN] 1532-2092
  • [Journal-full-title] Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • [ISO-abbreviation] Europace
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Hinterthaner M, Stamatis G: [Role of mediastinoscopy and repeat mediastinoscopy today]. Chirurg; 2008 Jan;79(1):38, 40-4
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  • For patients with lung cancer preoperative evaluation of the mediastinal lymph nodes is important to estimate local operability and/or to consider the necessity of neoadjuvant treatment.
  • Cervical mediastinoscopy is generally accepted as a safe and highly accurate procedure in the staging of lung cancer.
  • Additionally extended CM and left parasternal mediastinotomy allow the exploration of the aortopulmonary window (level 5) and anterior mediastinal nodes (level 6).
  • In locally advanced lung cancer repeat mediastinoscopy was used after induction chemotherapy or chemoradiation to reexplore the upper mediastinum in order to select patients with a higher probability to undergo complete resection.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Lymphatic Metastasis / diagnosis. Mediastinoscopy. Neoplasm Staging / methods
  • [MeSH-minor] Biopsy, Fine-Needle. Fluorodeoxyglucose F18. Humans. Lung / pathology. Lymph Nodes / pathology. Positron-Emission Tomography. Radiopharmaceuticals. Sensitivity and Specificity

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  • (PMID = 18209980.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 35
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17. Shimizu Y, Tsunezuka Y, Tanaka N: [A case of unresectable advanced thymic carcinoma in an elderly woman responding to S-1 with good QOL maintained]. Gan To Kagaku Ryoho; 2008 Nov;35(11):1977-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Because an anterior mediastinum tumor was noted by CT performed in the case of additional workup of left precordial pain noticed from approximately two months ago, she was admitted to our institution.
  • Because the patient strongly hoped for oral chemotherapy on an outpatient basis, we started treatment with S-1 100 mg/day (3 weeks administration, 2 weeks withdrawal).
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Oxonic Acid / therapeutic use. Quality of Life. Tegafur / therapeutic use. Thymoma / drug therapy. Thymoma / pathology
  • [MeSH-minor] Aged. Biopsy. Drug Combinations. Female. Humans. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 19011356.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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18. Kiernan PD, Sheridan MJ, Lamberti J, Dicicco B, Wigton R, Hetrick V, Vaughan B, Graling P: Mediastinal staging of non-small cell lung carcinoma using computed and positron-emission tomography. South Med J; 2002 Oct;95(10):1168-72
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal staging of non-small cell lung carcinoma using computed and positron-emission tomography.
  • BACKGROUND: We evaluated the accuracy of computed tomography (CT) and positron-emission tomography (PET) in the mediastinal staging of non-small cell lung cancer.
  • METHODS: Between May 14, 1999, and November 28, 2000, computerized tomography (CT) and positron-emission tomography (PET) were used to clinically stage 94 consecutive patients with non-small cell carcinoma of the lung (NSCCL).
  • All patients underwent subsequent surgical staging with mediastinoscopy, anterior mediastinotomy, and/or thoracotomy with mediastinal lymphadenectomy.
  • False-negative results occurred 3 times more often with CT; false-positive results occurred twice as often with PET.
  • CONCLUSION: In addition to routine use of CT, PET seems to achieve high negative predictive value in the evaluation of mediastinal disease; PET seems particularly helpful in assessing absence of tumor in bulky nodes after neoadjuvant chemotherapy and/or radiotherapy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Lung Neoplasms / diagnosis. Mediastinum / pathology. Neoplasm Staging. Tomography, X-Ray Computed
  • [MeSH-minor] False Negative Reactions. False Positive Reactions. Humans. Sensitivity and Specificity. Tomography, Emission-Computed

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  • (PMID = 12425503.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Turk HM, Ozet A, Ozturk M, Komurcu S, Kuzhan O, Arpaci F, Ozturk B, Safali M: Isolated renal relapse of a case with non-Hodgkin's lymphoma. Med Oncol; 2010 Jun;27(2):434-8
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  • A 29-year-old woman with left pleural effusion and a mass in anterior mediastinum was admitted.
  • After induction chemotherapy (four cycles of DHAP) she underwent high dose chemotherapy (BEAM) and autologous peripheral blood stem cell transplantation.
  • Although renal infiltration generally shows a poor prognosis, long-term survival may be achieved with high dose chemotherapy and autologous peripheral blood stem cell transplantation.
  • [MeSH-major] Kidney Neoplasms / diagnosis. Kidney Neoplasms / therapy. Lymphoma, Non-Hodgkin / diagnosis. Lymphoma, Non-Hodgkin / therapy. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / therapy

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  • (PMID = 19437146.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Rieker RJ, Muley T, Klein C, Schnabel PA, Herpel E, Meister M, Schirmacher P, Dienemann H, Pfannschmidt J: An institutional study on thymomas and thymic carcinomas: experience in 77 patients. Thorac Cardiovasc Surg; 2008 Apr;56(3):143-7
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Thymomas and thymic carcinomas are rare tumors of the anterior mediastinum.
  • Patients with an incomplete resection had a 5-year survival rate of only 29 % in spite of adjuvant radiation and/or chemotherapy.
  • Due to the high rate of relapse, the poor survival rate found in incompletely resected patients as well as the failure of classical chemotherapy regimens, especially in type B2 and type B3 thymomas and thymic carcinomas, the search for new chemotherapeutic schemes is mandatory.
  • CONCLUSION: Our study shows that there are still encouraging therapeutic options for thymomas and thymic carinomas.
  • Type B2, type B3 thymomas and thymic carcinomas have worse outcomes in spite of adjuvant chemo- and radiotherapies.
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Severity of Illness Index

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  • (PMID = 18365972.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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21. Stremmel C, Dango S, Thiemann U, Kayser G, Passlick B: [Thymoma--incidence, classification and therapy]. Dtsch Med Wochenschr; 2007 Oct;132(40):2090-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thymoma--incidence, classification and therapy].
  • [Transliterated title] Thymome--Inzidenz, Klassifikation und Therapie.
  • However, they represent 50 % of all tumors of the anterior mediastinum.
  • Surgical treatment remains the gold standard and must be performed whenever possible.
  • With respect of treatment only adjuvant radiation can possibly improve long term survival and reduces local recurrence rates for incomplete resected patients.
  • There is no evidence for a benefit in patients with thymoma receiving adjuvant chemotherapy.
  • A neo-adjuvant chemotherapy in combination with an adjuvant radiotherapy improves outcome after surgical resection in stage III and IV and goes along with better survival rates.
  • A multimodal therapy strategy is advised when dealing with thymomas in stage III and IV.
  • [MeSH-minor] Chemotherapy, Adjuvant. Humans. Lymph Node Excision. Lymphatic Metastasis. Neoadjuvant Therapy. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant

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  • (PMID = 17899505.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 48
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22. Kurup A, Loehrer PJ Sr: Thymoma and thymic carcinoma: therapeutic approaches. Clin Lung Cancer; 2004 Jul;6(1):28-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thymoma and thymic carcinoma: therapeutic approaches.
  • Thymomas and thymic carcinomas, which are rare epithelial tumors arising from the thymus gland, are the most common tumors of the anterior mediastinum.
  • Surgery is the treatment of choice for localized thymic tumors, with complete resection being the most important prognostic factor.
  • Adjuvant postoperative radiation therapy may improve the outcome in patients with invasive disease, although the data are conflicting.
  • Multimodal regimens, including neoadjuvant combination chemotherapy, surgery, and/or postoperative radiation therapy, are recommended for patients with advanced thymomas and thymic carcinomas.
  • [MeSH-major] Carcinoma / therapy. Thymoma / therapy. Thymus Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Clinical Trials as Topic. Combined Modality Therapy. Humans. Neoplasm Staging

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  • (PMID = 15310414.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 2 R 35 CA 39844-08; United States / NCI NIH HHS / CA / CA 23318; United States / NCI NIH HHS / CA / P 30 CA 82709-04; United States / NCI NIH HHS / CA / R 10 CA 28171-04; United States / NCI NIH HHS / CA / U 10 CA 21115
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 54
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23. Lara PN Jr: Malignant thymoma: current status and future directions. Cancer Treat Rev; 2000 Apr;26(2):127-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant thymomas are rare indolent tumours of the anterior superior mediastinum.
  • Patients are therefore diagnosed and staged at the time of definitive surgery.
  • Surgery is the principal treatment and is curative in early stage disease.
  • Radiation therapy, either alone or in combination with chemotherapy, is an option for both incompletely or completely resected disease.
  • Chemotherapy is offered to patients with locally advanced, recurrent, or metastatic thymoma, with excellent responses and prolonged survival.
  • Multicentre co-operative group clinical trials are required to assess novel thymoma therapies to maximize patient resources in this uncommon tumour.
  • [MeSH-major] Thymoma / diagnosis. Thymoma / therapy. Thymus Neoplasms / diagnosis. Thymus Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Forecasting. Humans. Neoplasm Staging. Salvage Therapy

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  • [Copyright] Copyright 2000 Harcourt Publishers Ltd.
  • (PMID = 10772969.001).
  • [ISSN] 0305-7372
  • [Journal-full-title] Cancer treatment reviews
  • [ISO-abbreviation] Cancer Treat. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] ENGLAND
  • [Number-of-references] 37
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24. Petersdorf SH, Wood DE: Lymphoproliferative disorders presenting as mediastinal neoplasms. Semin Thorac Cardiovasc Surg; 2000 Oct;12(4):290-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The mediastinum is an uncommon location for presentation of these heterogeneous disorders, but involvement of the mediastinum may be the sole site of disease for several aggressive lymphomas.
  • Both Hodgkin's disease and non-Hodgkin's lymphoma may present in the mediastinum.
  • The most common types of non-Hodgkin's lymphoma involving the mediastinum include lymphoblastic lymphoma and mediastinal large cell lymphoma.
  • These lymphomas most commonly develop in the anterior mediastinum but may be seen in the middle and posterior mediastinum.
  • Symptoms associated with a mediastinal presentation of a lymphoproliferative disorder are often attributable to compression of mediastinal structures (eg, superior vena cava syndrome) or invasion of thoracic structures such as the pericardium or pleura.
  • Once a diagnosis has been established, therapeutic modalities usually include chemotherapy and/or radiotherapy.
  • [MeSH-minor] Humans. Neoplasm Staging

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  • [Copyright] Copyright 2000 by W.B. Saunders Company
  • (PMID = 11154724.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] UNITED STATES
  • [Number-of-references] 41
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25. Elliott KS, Borowsky ME, Bakdounes K, Huang J, Abulafia O, Lee YC: Malignant thymoma metastatic to the pelvis: a rare case and considerations for management. Gynecol Oncol; 2005 Oct;99(1):228-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Thymoma is the most common tumor of the anterior mediastinum.
  • We present an unusual case of recurrent thymoma metastatic to the pelvis and review treatment experience employing surgical, radiotherapeutic and medical modalities.
  • CASE REPORT: The present case is that of a 46-year-old woman with recurrent thymoma metastatic to a distal pelvic lymph node.
  • Resection of the pelvic recurrence followed many years of local and systemic treatment for her thoracic primary tumor.
  • Her case is unique for its involvement of pelvic anatomy and her clinical course marked by treatment-related congestive heart failure.
  • CONCLUSION: While the indolent clinical course of thyomoma frequently necessitates re-treatment and multi-modality therapy in patients suffering recurrences, treatment selection must take into account potential long-term morbidity and attendant quality of life.
  • When anatomically and technically feasible, resection of recurrent disease should be considered in attempts to avoid potential cumulative and long-term toxicity resultant from radiotherapy and chemotherapy.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Pelvic Neoplasms / secondary. Thymoma / pathology

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  • (PMID = 16055177.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Tinica G, Butcovan D, Cimpeanu C, Târcoveanu E: A mediastinal germ cell tumor of yolk sac type--case report. Chirurgia (Bucur); 2010 Nov-Dec;105(6):831-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A mediastinal germ cell tumor of yolk sac type--case report.
  • OBJECTIVE: We report an extremely rare case of germ-cell tumor localized at the level of the anterior mediastinum.
  • Computed tomographic scan of the chest showed a large anterior mediastinal mass.
  • This supported the diagnosis of Yolk sac tumor, a rare primary tumor within the mediastinum.
  • Postsurgery, the patient received a combination chemotherapy consisting of cisplatin, vepesid and bleomycin every 3 weeks for a total of 4 cycles.
  • During the treatment, the alpha-fetoprotein level, was decreasing.
  • CONCLUSION: Primary mediastinal Yolk sac neoplasm is a rare tumor.
  • In spite of modern chemotherapy, the prognosis of mediastinal yolk sac tumor remains poor.
  • The single most important prognostic indicator is whether the tumor mass can be completely excised before or after chemotherapy.
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Biopsy. Bleomycin / administration & dosage. Carcinoma / diagnosis. Cisplatin / administration & dosage. Diagnosis, Differential. Etoposide / administration & dosage. Humans. Male. Prognosis. alpha-Fetoproteins / metabolism

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  • (PMID = 21351701.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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27. Thomas PA, Payan-Defais MJ: [Epithelial tumours of the thymus]. Rev Pneumol Clin; 2010 Feb;66(1):41-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rare, they nevertheless represent 20% of all mediastinal tumours and 50% of those located in the anterior mediastinum.
  • However, even patients with an invasive disease may have a long clinical history, explaining that a 10-year or 20-year survival from diagnosis does not imply a definitive cure.
  • In daily practice, both the clinical Masaoka's staging system and the WHO histological classification condition the treatment strategies and allow to anticipate the prognosis.
  • The initial treatment, as well as that of the recurrence, is based mainly on a complete resection.
  • Postoperative radiotherapy is systematically added to the treatment of invasive tumours and/or to those with an aggressive histological subtype.
  • Inoperable or metastatic tumours require a cisplatine and anthracyclin-based chemotherapy, followed by radical surgery and/or radiotherapy.
  • [MeSH-minor] Combined Modality Therapy. Disease Progression. Humans. Myasthenia Gravis / pathology. Myasthenia Gravis / surgery. Neoplasm Invasiveness / pathology. Neoplasm Staging. Radiotherapy, Adjuvant. Survival Analysis. Thymus Gland / pathology

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20207296.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 44
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28. Port JL, Ginsberg RJ: Surgery for thymoma. Chest Surg Clin N Am; 2001 May;11(2):421-37
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although thymoma is an uncommon tumor, it represents the most frequently encountered tumor of the anterior mediastinum.
  • The initial treatment of choice for patients with thymoma that do not present with unresectable local or diffuse metastatic disease is complete surgical resection.
  • With recurrences appearing up to 5 and even 10 years postoperatively, time will tell if these minimally invasive techniques are comparable with current standard approaches.
  • Multiple studies have failed to determine conclusively the role of induction chemotherapy and adjuvant radiation.
  • Prospective multi-institutional trials are required to elucidate further the role of such therapies in these rare tumors.
  • Some promising reports on response to chemotherapy have led them to develop an induction chemotherapy protocol for patients with clinically advanced disease.
  • [MeSH-minor] Combined Modality Therapy. Humans. Neoplasm Staging. Thymectomy / methods

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  • (PMID = 11413765.001).
  • [ISSN] 1052-3359
  • [Journal-full-title] Chest surgery clinics of North America
  • [ISO-abbreviation] Chest Surg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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29. Stefanou D, Goussia AC, Arkoumani E, Metafratzi ZM, Syminelakis S, Arkoumani E, Agnantis NJ: Mucoepidermoid carcinoma of the thymus: a case presentation and a literature review. Pathol Res Pract; 2004;200(7-8):567-73
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  • As heart function tests were normal, the patient underwent radiologic examination, which showed a well-demarcated mass in the anterior mediastinum.
  • Histologic examination of the surgically resected mass showed features of a mucoepidermoid carcinoma with associated infiltration of the pleural tissue.
  • Postoperative radiotherapy and chemotherapy were performed, and the patient died two months after initial diagnosis.
  • [MeSH-minor] Combined Modality Therapy. Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Invasiveness. Pleura / pathology. Tomography, X-Ray Computed

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  • (PMID = 15462505.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 11
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30. Hernandez-Ilizaliturri FJ, Tan D, Cipolla D, Connolly G, Debb G, Ramnath N: Multimodality therapy for thymic carcinoma (TCA): results of a 30-year single-institution experience. Am J Clin Oncol; 2004 Feb;27(1):68-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multimodality therapy for thymic carcinoma (TCA): results of a 30-year single-institution experience.
  • SUMMARY: The aim of this study was to correlate the clinicopathologic features and therapeutic approaches with the outcome of patients with thymic carcinoma (TCA), an aggressive, uncommon malignancy of the anterior mediastinum.
  • The Roswell Park Cancer Institute tumor registry was used to identify patients with TCA or invasive thymic neoplasm of the epithelial type (TNET).
  • Postoperative cisplatin-based chemotherapy and radiation was administered to seven patients.
  • Incomplete surgical resection did not preclude long-term survival if multimodality platinum-based therapy was used.
  • [MeSH-major] Thymus Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Survival Analysis. Treatment Outcome

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  • [ErratumIn] Am J Clin Oncol. 2004 Apr;27(2):127
  • (PMID = 14758136.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Matsuoka T, Kobayashi S, Oka K, Sakano H, Kawano K, Katoh T: [Thymic cancer with superior vena cava invasion reconstructed by ready-made Y-graft]. Kyobu Geka; 2010 May;63(5):379-81
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  • Computed tomography (CT) showed the lobulated tumor suspected of superior vena cava (SVC) invasion, located in the anterior mediastinum, 5 x 3 cm in size.
  • Postoperative radiotherapy (RT : 12.6 Gy) was canceled for the side effect.
  • Alternatively, adjuvant chemotherapy [carboplatin (CBDCA) +paclitaxel (PTX)] was administered.
  • Additional RT (50 Gy) was given to the lesion of local recurrence 1 and half year after the operation.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Neoplasm Invasiveness / pathology. Thymus Neoplasms / pathology. Vena Cava, Superior / pathology. Vena Cava, Superior / surgery

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  • (PMID = 20446606.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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32. Rajan A, Giaccone G: Treatment of advanced thymoma and thymic carcinoma. Curr Treat Options Oncol; 2008 Dec;9(4-6):277-87
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of advanced thymoma and thymic carcinoma.
  • Although thymic epithelial tumors are rare, they are relatively common among neoplasms of the anterior superior mediastinum.
  • The mainstay of therapy is complete surgical resection.
  • Locally advanced thymoma and thymic carcinoma require a multimodality treatment approach with a combination of surgery, chemotherapy, and radiation therapy to decrease the chances of recurrence and improve survival.
  • The risk of disease recurrence lasts for a number of years after completion of primary therapy.
  • Once again, surgical resection of recurrent disease represents the cornerstone of successful therapy and is critical to long-term survival.
  • In recent years, a better understanding of the biologic basis of thymic epithelial tumors has led to the emergence of targeted therapy directed against this malignancy.
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Humans. Middle Aged. Neoplasm Staging. Survival Rate. Survivors

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  • (PMID = 19381821.001).
  • [ISSN] 1534-6277
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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33. Elkiran ET, Abali H, Aksoy S, Altundag K, Erman M, Kars A, Turker A, Tekuzman G, Ozisik Y: Thymic epithelial neoplasia: a study of 58 cases. Med Oncol; 2007;24(2):197-201
MedlinePlus Health Information. consumer health - Thymus Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thymic epithelial neoplasia: a study of 58 cases.
  • Primary thymic epithelial neoplasms (PTENs) are uncommon tumors of anterior mediastinum with a broad range of biological characteristics.
  • Eleven (19.0%) out of 58 who presented at advanced stages (at least III) received chemotherapy.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 17848744.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Okubo K, Kobayashi M, Morikawa H, Hayatsu E: Easier node dissection after chemoradiotherapy for lung cancer with collagen insertion at mediastinoscopy. Jpn J Thorac Cardiovasc Surg; 2006 Jul;54(7):268-72
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Induction chemoradiotherapy followed by anatomical resection is a current therapeutic strategy for non-small-cell lung cancer with mediastinal node involvement.
  • We evaluated a novel technique to make the mediastinal node dissection easier after induction therapy.
  • METHODS: At the end of mediastinoscopic node biopsy for staging of lung cancer, cotton-type collagen was inserted anterior and lateral to the trachea in patients with pathologically confirmed mediastinal node involvement (n=45).
  • The induction therapy consisted of concurrent use of platinum-based chemotherapy and hyperfractionated radiotherapy.
  • Surgical findings of the mediastinum and the time for node dissection were compared with those without collagen insertion at mediastinoscopy after chemoradiotherapy (n=5).
  • Mediastinal node dissection was easily accomplished by removing mediastinal tissues lateral and anterior to the collagen.
  • The times for node dissection in patients with and without collagen insertion showed no significant difference.
  • CONCLUSION: Cotton-type collagen insertion at staging mediastinoscopy for lung cancer separates the mediastinal nodes from the trachea and makes the node dissection easier after induction chemoradiotherapy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Non-Small-Cell Lung / therapy. Collagen / therapeutic use. Lung Neoplasms / diagnosis. Lung Neoplasms / therapy. Lymph Node Excision. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / surgery. Mediastinoscopy
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Female. Humans. Japan. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Remission Induction. Retrospective Studies. Sentinel Lymph Node Biopsy. Trachea / surgery. Treatment Outcome

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  • (PMID = 16898638.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 9007-34-5 / Collagen
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