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1. Xu J, Wang J, Cui L, Wu X: Malignant inguinal monophasic synovial sarcoma: report of a case and review of the literature. World J Surg Oncol; 2010;8:102
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  • [Title] Malignant inguinal monophasic synovial sarcoma: report of a case and review of the literature.
  • BACKGROUND: A synovial sarcoma (SS) is an aggressive soft tissue tumor that classically occurs in the extremities near, but rarely within large joints, in young adults.
  • This poses certain difficulties in arriving at a prompt diagnosis and appropriate treatment.
  • She underwent surgery, and later received systematic intravenous chemotherapy.
  • The pathological studies, especially the specific chromosomal translocation of a t(X;18) (p11.2;q11.2), confirmed the diagnosis as a synovial sarcoma.
  • To the best of our knowledge, this is the first report of a monophasic synovial sarcoma in the inguinal region.
  • CONCLUSION: Besides making the readership aware of the rarity of location and age of this present case, this report distinctly highlights the great value of a molecular analysis of an SYT associated genetic alteration in the diagnosis of synovial sarcoma occurring at rare sites especially when immunochemical results are equivocal.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Inguinal Canal. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Laparotomy. Tomography, X-Ray Computed. Ultrasonography, Doppler

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  • (PMID = 21092139.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ PMC2995789
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2. Park SJ, Kim HK, Kim CK, Park SK, Go ES, Kim ME, Hong DS: A case of renal synovial sarcoma: complete remission was induced by chemotherapy with doxorubicin and ifosfamide. Korean J Intern Med; 2004 Mar;19(1):62-5
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  • [Title] A case of renal synovial sarcoma: complete remission was induced by chemotherapy with doxorubicin and ifosfamide.
  • We experienced a case of primary renal synovial sarcoma in a 32 year-old woman.
  • On radiologic examination, a 12 x 10 cm-sized soft tissue mass was detected on the left kidney.
  • The tumor had histologic and immunophenotypic features that were consistent with spindle cell type monophasic synovial sarcoma.
  • Four months after complete resection of the tumor, a unilateral hematogenous metastasis developed in the lung.
  • She was treated with combined chemotherapy of doxorubicin and ifosfamide every four weeks, and complete remission was achieved.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Kidney Neoplasms / surgery. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Sarcoma, Synovial / drug therapy. Sarcoma, Synovial / secondary

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  • (PMID = 15053047.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
  • [Other-IDs] NLM/ PMC4531551
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3. Capelli M, Bertino G, Morbini P, Proh M, Falco CE, Benazzo M: CO2 laser in the treatment of laryngeal synovial sarcoma: a clinical case. Tumori; 2007 May-Jun;93(3):296-9
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  • [Title] CO2 laser in the treatment of laryngeal synovial sarcoma: a clinical case.
  • Synovial sarcoma is a rare mesenchymal neoplasm that is usually located in the limbs.
  • Two histological variants have been described, a biphasic and a monophasic variant.
  • Immunohistochemistry is determinant in the differential diagnosis between synovial sarcoma and other spindle and biphasic neoplasms.
  • The treatment of choice is conservative surgery with tumor-free margins, while radiotherapy is effective in local control of the disease after recurrence.
  • Chemotherapy is indicated for the treatment of distant metastases.
  • We present a case of monophasic synovial sarcoma of the laryngeal ventricle that was successfully treated with CO2 laser excision and we briefly review the literature on the subject.
  • [MeSH-major] Laryngeal Neoplasms / surgery. Laser Therapy / methods. Sarcoma, Synovial / surgery

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  • (PMID = 17679468.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
  • [Number-of-references] 38
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4. Iwata T, Nishiyama N, Izumi N, Tsukioka T, Suehiro S: Metastatic monophasic synovial sarcoma of the pleura. Ann Thorac Cardiovasc Surg; 2007 Aug;13(4):258-61
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  • [Title] Metastatic monophasic synovial sarcoma of the pleura.
  • Pleural metastasis of synovial sarcoma that originally developed in the soft tissue is a very rare entity.
  • An asymptomatic 25-year-old female, with a history of a resected synovial sarcoma in her left brachial muscle and pulmonary metastasectomy of the right lung, presented a small nodule in the periphery of the left lung on a routine chest-computed tomography.
  • Intraoperative frozen sectioning evidenced metastatic synovial sarcoma.
  • We diagnosed unresectable pleural metastases of synovial sarcoma and finished the operation after sampling another pulmonary pleural lesion.
  • The patient then underwent ifomide-based chemotherapy and survived for 3 years after her initial surgery.
  • Postoperative histopathological examination revealed a solid and bundle-like proliferation of a short spindle cell tumor with a monophasic pattern, which was diagnosed as a metastatic pleural synovial sarcoma.
  • [MeSH-major] Muscle Neoplasms / pathology. Pleural Neoplasms / secondary. Sarcoma, Synovial / secondary

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  • (PMID = 17717503.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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5. Artico R, Bison E, Brotto M: Monophasic synovial sarcoma of hypopharynx: case report and review of the literature. Acta Otorhinolaryngol Ital; 2004 Feb;24(1):33-6
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  • [Title] Monophasic synovial sarcoma of hypopharynx: case report and review of the literature.
  • Synovial sarcoma (SS) is a malignant mesenchymal neoplasm usually involving the lower limbs of young adults.
  • Histologically, these are characterised by a biphasic or monophasic variant, the latter being more rare and difficult to identify.
  • Cytogenetics also play an important role since both the monophasic and the biphasic forms are characterised by a reciprocal translocation (x;18) (p 11.2;q 11.2).
  • Treatment options include an aggressive surgical approach and radiotherapy, whereas the role of chemotherapy remains to be defined.
  • The case is described of monophasic synovial sarcoma located in the hypopharynx and a review is made of the literature concerning this rare neoplasm.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Hypopharyngeal Neoplasms / radiography. Sarcoma, Synovial / pathology. Sarcoma, Synovial / radiography
  • [MeSH-minor] Adult. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 15270432.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 22
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6. Srivastava A, Nielsen PG, Dal Cin P, Rosenberg AE: Monophasic synovial sarcoma of the liver. Arch Pathol Lab Med; 2005 Aug;129(8):1047-9
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  • [Title] Monophasic synovial sarcoma of the liver.
  • We report a hepatic monophasic synovial sarcoma in a 60-year-old woman who presented with right upper quadrant pain subsequent to an intrahepatic bleed from a highly vascular tumor mass.
  • The morphologic, immunophenotypic, and cytogenetic findings (t(X;18)(p11.2;icq11.2)) were consistent with a monophasic synovial sarcoma.
  • The patient was started on an aggressive 4-drug chemotherapy regimen, but died 3 months thereafter from widespread metastatic disease.
  • It would, however, be very unusual for a synovial sarcoma to present as an occult primary, and the negative radiologic workup 1 month after the partial hepatectomy also argues against this possibility.
  • The clinical presentation, radiographic findings, and subsequent course in this patient was therefore most consistent with a primary monophasic synovial sarcoma of the liver.
  • [MeSH-major] Liver Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Carcinoma, Hepatocellular / diagnosis. Chemotherapy, Adjuvant. Chromosomes, Human, Pair 18. Chromosomes, Human, X. Diagnosis, Differential. Fatal Outcome. Female. Genetic Markers. Hemangiosarcoma / diagnosis. Hepatectomy. Humans. Middle Aged. Translocation, Genetic

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  • (PMID = 16048399.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
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7. Eilber FC, Brennan MF, Eilber FR, Eckardt JJ, Grobmyer SR, Riedel E, Forscher C, Maki RG, Singer S: Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Ann Surg; 2007 Jul;246(1):105-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma.
  • PURPOSE: To determine if ifosfamide-based chemotherapy (IF) offers a survival benefit to adult patients with primary extremity synovial sarcoma.
  • PATIENTS AND METHODS: Prospectively collected patient data from 2 institutions was used to identify all adult patients (>or=16 years) with >or=5 cm, deep, primary, extremity, synovial sarcoma that underwent surgical treatment of cure from 1990 to 2002.
  • Clinical, pathologic, and treatment variables were analyzed for disease-specific survival (DSS), distant recurrence-free survival (DRFS), and local recurrence-free survival (LRFS).
  • RESULTS: Sixty-eight (67%) patients were treated with IF and 33 (33%) patients received no chemotherapy (NoC) for the primary tumor.
  • The characteristics of the IF-treated patients [median tumor size = 7.2 cm; monophasic n = 46 (68%)] were similar to NoC patients [median tumor size = 7 cm; monophasic n = 23 (70%)].
  • Smaller size (HR = 0.3 per 5-cm decrease, P < 0.0001) and treatment with IF (HR = 0.3 compared with NoC, P = 0.007) were independently associated with an improved DSS.
  • Treatment with IF was independently associated with an improved DRFS (HR = 0.4, P = 0.03) but not associated with an improved LRFS (P = 0.39).
  • CONCLUSION: Ifosfamide-based chemotherapy was associated with an improved DSS in adult patients with high-risk, primary, extremity, synovial sarcoma and should be considered in the treatment of such patients.

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  • (PMID = 17592298.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / P01CA47179
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents, Alkylating; 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
  • [Other-IDs] NLM/ PMC1899195
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8. Domşa I, Crişan D, Olinici CD: Retroperitoneal synovial sarcoma. Rom J Morphol Embryol; 2006;47(2):187-91
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  • [Title] Retroperitoneal synovial sarcoma.
  • Retroperitoneal synovial sarcomas are very rare.
  • The authors describe a 39-year-old male with a primary retroperitoneal synovial sarcoma showing a monophasic pattern.
  • The differential diagnosis, clinical evolution and principles of treatment are shortly discussed.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Retroperitoneal Neoplasms / drug therapy. Retroperitoneal Neoplasms / pathology. Sarcoma, Synovial / pathology. Thoracic Neoplasms / pathology

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  • (PMID = 17106529.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; NR7O1405Q9 / Mesna; UM20QQM95Y / Ifosfamide; MAID protocol
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9. White BE, Kaplan A, Lopez-Terrada DH, Ro JY, Benjamin RS, Ayala AG: Monophasic synovial sarcoma arising in the vulva: a case report and review of the literature. Arch Pathol Lab Med; 2008 Apr;132(4):698-702
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  • [Title] Monophasic synovial sarcoma arising in the vulva: a case report and review of the literature.
  • Synovial sarcomas most commonly arise in the soft tissue of the extremities.
  • However, synovial sarcoma occurring in the vulvar area is extremely rare.
  • Only 2 previous cases of biphasic synovial sarcoma of the vulva have been reported, but no case of vulvar monophasic synovial sarcoma has been described in the English literature.
  • We report the third case of synovial sarcoma and apparently the first case of monophasic synovial sarcoma arising in soft tissues of the vulva.
  • The tumor was located in the deep fibroadipose tissue of the right vulva (6.5 x 4.2 x 3.5 cm).
  • The histology of the lesion was that of a monophasic synovial sarcoma with a hemangiopericytic vascular pattern.
  • A subsequent molecular analysis revealed SYT-SSX2 gene fusion, which confirmed the diagnosis of synovial sarcoma.
  • After an initial wide local excision, the patient developed a recurrence in the right groin and received chemotherapy and additional surgery.
  • The patient is currently disease free, on adjuvant chemotherapy, and being followed up closely.
  • [MeSH-major] Sarcoma, Synovial / diagnosis. Vulvar Neoplasms / diagnosis

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  • (PMID = 18384223.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; 0 / SS18 protein, human; 164289-47-8 / synovial sarcoma X breakpoint proteins
  • [Number-of-references] 17
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10. Gotoh M, Furukawa S, Motoishi M, Fujimoto T, Okazaki T, Matsukura T, Hanawa T, Yamashita N, Matsui T, Kuwabara M, Matsubara Y: Synovial sarcoma of the mediastinum: report of a case. Surg Today; 2004;34(6):521-4
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  • [Title] Synovial sarcoma of the mediastinum: report of a case.
  • We report a case of synovial sarcoma of the mediastinum, a very rare tumor, in a 50-year-old man hospitalized with anterior chest pain.
  • Chest X-ray and computed tomography (CT) on admission showed a 10 x 8-cm mass in the right anterior mediastinal space, compressing the superior vena cava.
  • A diagnosis of sarcoma was established by a CT-guided percutaneous needle biopsy.
  • Systemic examination revealed no metastasis to the contralateral pleural cavity or other distant organs, and we resected the mediastinal sarcoma.
  • Pathological and immunohistochemical analyses confirmed a diagnosis of monophasic synovial sarcoma.
  • The patient is alive with recurrence 9 months after his operation, and is receiving chemotherapy with ifosfamide.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / surgery. Sarcoma, Synovial / pathology. Sarcoma, Synovial / surgery
  • [MeSH-minor] Humans. Immunohistochemistry. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 15170549.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Nishiyama N, Iwata T, Izumi N, Tsukioka T, Nagano K, Suehiro S: Aggressive repeat surgery for a recurrent synovial sarcoma in the pleura. Ann Thorac Cardiovasc Surg; 2009 Feb;15(1):46-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aggressive repeat surgery for a recurrent synovial sarcoma in the pleura.
  • Pleural synovial sarcomas are an extremely rare disease entity, and only 21 surgical cases, including this one, have been reported.
  • We present a case of synovial sarcoma that underwent pneumonectomy for a recurrence of the disease.
  • A 31-year-old female, who in June 2005 had undergone surgical resection of a monophasic synovial sarcoma in the left pleural cavity combined with the affected left diaphragm, was admitted to our hospital in January 2007 and underwent chemotherapy with ifosfamide, pirarubicin, and methotrexate for a recurrent synovial sarcoma in the left pleural cavity.
  • The chest computed tomography revealed multiple tumors in the left pleura, and the tumors increased rapidly to occupy the left hemithorax.
  • Pathological examination revealed dense proliferation of atypical spindle cells, the same findings as in the initial operation, and a diagnosis of synovial sarcoma was made.
  • External radiation therapy up to 60 Gray was given to the tumor remaining around the descending aorta.
  • Although optimal strategies for synovial sarcoma have yet to be established, aggressive repeat surgery could be considered in selected cases even when response to chemotherapy is insufficient and complete resection is difficult.
  • [MeSH-major] Neoplasm Recurrence, Local. Pleural Neoplasms / surgery. Pneumonectomy. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Female. Humans. Radiotherapy, Adjuvant. Reoperation. Thoracotomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19262450.001).
  • [ISSN] 2186-1005
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Etienne-Mastroianni B, Falchero L, Chalabreysse L, Loire R, Ranchère D, Souquet PJ, Cordier JF: Primary sarcomas of the lung: a clinicopathologic study of 12 cases. Lung Cancer; 2002 Dec;38(3):283-9
MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To study patients with primary sarcomas of the lung diagnosed in our pathology department in order to define their clinical characteristics, treatment, and prognosis.
  • The histologic diagnoses confirmed in all cases by detailed immunohistochemical study were leiomyosarcoma (7), monophasic synovial sarcoma (2), one case each of malignant peripheral nerve sheath tumor (MPNST), epithelioid sarcoma, and malignant fibrous histiocytoma.
  • Four patients received chemotherapy and two patients had radiation therapy postoperatively.
  • Treatment and prognosis do not differ from other soft tissue sarcomas.
  • [MeSH-major] Lung Neoplasms / pathology. Sarcoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 12445750.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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13. Eilber FC, Eilber FR, Eckardt JJ, Rosen G, Forscher C, Maki RG, Grobmyer SR, Brennan MF, Singer S: Impact of ifosfamide-based chemotherapy on survival in patients with primary extremity synovial sarcoma. J Clin Oncol; 2004 Jul 15;22(14_suppl):9017

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of ifosfamide-based chemotherapy on survival in patients with primary extremity synovial sarcoma.
  • : 9017 Background: The impact of adjuvant chemotherapy on the survival of patients with soft tissue sarcoma is controversial.
  • Although ifosfamide based chemotherapy (IF) has generated significant responses in the treatment of metastatic synovial sarcoma, its effect on the survival of patients with primary disease remains unclear.
  • The objective of this study is to determine if IF offers a survival benefit to patients with primary extremity synovial sarcoma.
  • METHODS: Two prospectively collected sarcoma databases were used to identify a contemporary cohort of 101 adult (≥16yrs) patients with primary, extremity, ≥5cm, deep, synovial sarcomas that underwent surgical treatment for cure from 1990 to 2002.
  • 68 patients were treated with IF and 33 received no chemotherapy (NoC).
  • Clinical, pathologic and treatment variables were analyzed for disease specific survival (DSS) and distant recurrence free survival (DRFS).
  • 90%(91/101) underwent limb-sparing surgery and 97%(88/91) of these patients received radiation therapy.
  • The characteristics of the 68 IF treated patients [median age=34, median size=7.2cm, monophasic n=47(69%)] were very similar to the 33 NoC patients [median age=37, median size=7, monophasic n=24(72%)].
  • CONCLUSIONS: Ifosfamide based chemotherapy is associated with improved DRFS and DSS in patients with large, primary, extremity synovial sarcoma.

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  • (PMID = 28013672.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Castillo Fernandez OO, Pacheco M, Lim M, Singh C: Prognostic factors in synovial sarcoma. J Clin Oncol; 2009 May 20;27(15_suppl):e21525

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors in synovial sarcoma.
  • : e21525 Background: Synovial sarcoma (SS) is a relatively rare type of soft tissue sarcoma.
  • Demographic, clinical, pathological, and therapeutic variables were reviewed.
  • Histological type; monophasic 78%, biphasic 22%.
  • TREATMENT: adjuvant treatment 52% (3 chemotherapy only, 7 radiation therapy, 4 both).
  • In patients with localized disease, time to recurrence decreased with histological grade (p=0.05 ns).

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  • (PMID = 27963455.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Abdelkrim SB, Trabelsi A, Hammedi F, Boudagga MZ, Bdioui A, Jomaa W, Mokni M: Synovial Sarcoma: A Clinicopathological and Radiological Study of 12 Cases Seen Over 18 Years. World J Oncol; 2010 Feb;1(1):14-18

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial Sarcoma: A Clinicopathological and Radiological Study of 12 Cases Seen Over 18 Years.
  • Background: Synovial sarcoma is a rare malignant soft tissue tumor characterized by a poor outcome.
  • We report herein our experience concerning synovial sarcoma and review its diagnosis, histology, treatment and prognosis.
  • Methods: This is a retrospective review, from 1990 to 2007, of cases of synovial sarcoma diagnosed at the Department of Pathology, Farhat Hached hospital, Sousse, Tunisia.
  • The clinical, radiological and pathological features as well as treatment modalities and patient's outcome were recorded.
  • Results: From 1990 to 2007, 12 cases of synovial sarcoma have been diagnosed in our department.
  • Patients' mean age at the time of diagnosis was 21 years.
  • Ten patients underwent surgery, in association with adjuvant chemotherapy in 4 cases, one of whom underwent post-operative radiotherapy.
  • Histological subtypes included monophasic synovial sarcoma in 8 cases, biphasic synovial sarcoma in 3 cases and poorly differentiated synovial sarcoma in one case.
  • At the time of analysis, 6 patients were dead with an average follow-up of 18 months.
  • Conclusions: Synovial sarcoma is a rare malignancy with a propensity for young adults and a poor prognosis.
  • Diagnosis can be suggested by radiology and definitive diagnosis is achieved after pathological analysis.

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  • [Cites] Med Sci Monit. 2008 Jun;14(6):CR305-310 [18509273.001]
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  • (PMID = 29147174.001).
  • [ISSN] 1920-454X
  • [Journal-full-title] World journal of oncology
  • [ISO-abbreviation] World J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Histology / Prognosis / Radiology / Synovial sarcoma / Treatment
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16. Paulino AC: Synovial sarcoma prognostic factors and patterns of failure. Am J Clin Oncol; 2004 Apr;27(2):122-7
Genetic Alliance. consumer health - Synovial sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial sarcoma prognostic factors and patterns of failure.
  • From 1970 to 1999, 44 patients with synovial sarcoma were seen at the University of Iowa.
  • Histologic classification was biphasic in 26 (59%) and monophasic in 18 (41%).
  • For the 37 nonmetastatic patients, local treatment consisted of wide local excision in 29 and amputation in 8; chemotherapy was administered to 10.
  • Of the 19 patients who developed distant metastasis, 5 (26%) failed >5 years and 2 (11%) failed >15 years of follow-up.
  • Late distant relapses can occur with synovial sarcoma.
  • [MeSH-major] Sarcoma, Synovial / mortality. Sarcoma, Synovial / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis. Proportional Hazards Models. Survival Analysis. Treatment Failure

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  • (PMID = 15057149.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Koh KH, Cho EY, Kim DW, Seo SW: Multivariate analysis of prognostic factors in synovial sarcoma. Orthopedics; 2009 Nov;32(11):824
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multivariate analysis of prognostic factors in synovial sarcoma.
  • Many studies have described the diversity of synovial sarcoma in terms of its biological characteristics and clinical features.
  • Moreover, much effort has been expended on the identification of prognostic factors because of unpredictable behaviors of synovial sarcomas.
  • Forty-one consecutive patients with synovial sarcoma were prospectively followed from January 1997 to March 2008.
  • Overall and progression-free survival for age, sex, tumor size, tumor location, metastasis at presentation, histologic subtype, chemotherapy, radiation therapy, and resection margin were analyzed, and standard multivariate Cox proportional hazard regression analysis was used to evaluate potential prognostic factors.
  • Tumor size (>5 cm), nonlimb-based tumors, metastasis at presentation, and a monophasic subtype were associated with poorer overall survival.
  • Multivariate analysis showed metastasis at presentation and monophasic tumor subtype affected overall survival.
  • For the progression-free survival, monophasic subtype was found to be only 1 prognostic factor.
  • The study confirmed that histologic subtype is the single most important independent prognostic factors of synovial sarcoma regardless of tumor stage.
  • [MeSH-major] Sarcoma, Synovial / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Child. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging. Prognosis. Proportional Hazards Models. Prospective Studies. Radiotherapy, Adjuvant. Young Adult

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  • (PMID = 19902890.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Okcu MF, Despa S, Choroszy M, Berrak SG, Cangir A, Jaffe N, Raney RB: Synovial sarcoma in children and adolescents: thirty three years of experience with multimodal therapy. Med Pediatr Oncol; 2001 Aug;37(2):90-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial sarcoma in children and adolescents: thirty three years of experience with multimodal therapy.
  • BACKGROUND: Synovial sarcoma (SS) is the most common type of non-rhabdomyosarcoma soft tissue sarcoma in childhood, with controversies about its prognosis and treatment.
  • PROCEDURE: We reviewed medical records of 42 children and adolescents with SS treated at our institution between 1966 and 1999 to determine treatment results and assess prognostic factors.
  • Eleven patients were dead and four others had progressed but were alive without evidence of disease after further therapy.
  • Patients with small tumors (< 5 cm) (P = 0.09) or with monophasic histology (P = 0.14) had better PFS and OS.
  • Chemotherapy did not seem to impact PFS or OS.
  • Future large multi-institutional trials are needed to address whether post-operative chemotherapy is necessary for patients with localized, surgically removed tumors, whether radiotherapy is necessary for patients with completely resected tumors, and to ascertain the order of importance of all the candidate prognostic markers.
  • [MeSH-major] Sarcoma, Synovial / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Chemotherapy, Adjuvant. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright 2001 Wiley-Liss, Inc.
  • (PMID = 11496345.001).
  • [ISSN] 0098-1532
  • [Journal-full-title] Medical and pediatric oncology
  • [ISO-abbreviation] Med. Pediatr. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Luo CW, Liu CJ, Chang KM: Synovial sarcoma of the temporomandibular joint area: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Oct;104(4):e62-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial sarcoma of the temporomandibular joint area: report of a case.
  • Synovial cell sarcoma is a relatively rare tumor of mesenchymal origin.
  • It is a high-grade neoplasm that microscopically shows a monophasic or biphasic cellular pattern and includes epithelial features as well as supporting tissue features.
  • Surgical excision is the primary mode of treatment.
  • Postoperative radiotherapy and chemotherapy also is seen to be helpful.
  • A review of relevant literature shows less than 10 cases of synovial cell sarcoma of the temporomandibular joint area reported in the English literature.
  • We report an additional case of biphasic synovial cell sarcoma arising in the temporomandibular joint area, which caused ear pain, tinnitus, and hearing loss, and we further discuss the clinical features, histopathology, differential diagnosis, and treatment modality.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Sarcoma, Synovial / pathology. Temporomandibular Joint Disorders / pathology

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  • (PMID = 17703967.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Kuehnemund M, Friedrichs N, Bootz F: [Synovial sarcoma of the head and neck]. Laryngorhinootologie; 2008 Jul;87(7):498-502
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Synovial sarcoma of the head and neck].
  • BACKGROUND: Synovial sarcoma (SS) is a mesenchymal malignancy, which predominantly occurs at the lower extremities of young adults.
  • 3 patients underwent radical surgery followed by chemotherapy, 2 in combination with irradiation.
  • 1 patient underwent primary chemotherapy and irradiation.
  • The histological diagnosis was a biphasic SS as well as a monophasic SS in 2 patients respectively.
  • CONCLUSIONS: The aggressive character of the SS as well as its high recurrence rate afford a radical therapeutic scheme enclosing surgical, chemotherapeutical and radiological treatment as well as a thorough follow-up.
  • [MeSH-major] Otorhinolaryngologic Neoplasms / diagnosis. Sarcoma, Synovial / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Child. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / diagnosis. Lymphatic Metastasis / pathology. Magnetic Resonance Imaging. Male. Mucin-1 / analysis. Neoplasm Staging. Vimentin / analysis

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  • (PMID = 18231962.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / Vimentin
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21. Henninger B, Freund M, Zelger B, Putzer D, Bonatti H, Müller L, Fiegl M, Geltner C: Primary mediastinal synovial sarcoma: a case report and review of the literature. Cases J; 2009;2:6948

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mediastinal synovial sarcoma: a case report and review of the literature.
  • Primary mediastinal synovial sarcoma is a rare malignancy with only a few cases reported so far.
  • Computed tomography revealed a mediastinal mass first described as a solitary fibrous tumor.
  • The diagnosis of synovial sarcoma was established by computed tomography-guided percutaneous needle biopsy.
  • The mass was surgically resected; pathological and immunohistochemical analyses confirmed the diagnosis of a monophasic spindle cell synovial sarcoma probably originating from phrenic nerve.
  • The patient received adjuvant chemotherapy and radiation and is free of recurrence after a follow up of 16 months.

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  • (PMID = 19918499.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2769329
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22. Mancuso T, Mezzelani A, Riva C, Fabbri A, Dal Bo L, Sampietro G, Perego P, Casali P, Zunino F, Sozzi G, Pierotti MA, Pilotti S: Analysis of SYT-SSX fusion transcripts and bcl-2 expression and phosphorylation status in synovial sarcoma. Lab Invest; 2000 Jun;80(6):805-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of SYT-SSX fusion transcripts and bcl-2 expression and phosphorylation status in synovial sarcoma.
  • Synovial sarcomas (SS) are characterized by a chromosomal translocation t(X;18)(p11.2;q11.2) which usually fuses the SYT gene from chromosome 18 to SSX1 or SSX2 genes on chromosome X.
  • Our results showed a significant correlation between the SYT-SSX2 fusion and the monophasic SS histologic subtype.
  • SYT-SSX1 fusion transcripts were present in both monophasic and biphasic tumors.
  • The SYT-SSX4 fusion type was detected in a single monophasic SS.
  • Finally, we show that bcl-2 is not phosphorylated in tumors from patients who had been preoperatively treated with radio/chemotherapy, in tumors from untreated patients, or in an SS cell line (CME-1) after in vitro treatment with cytotoxic concentrations of DNA-damaging agents or taxanes.
  • These data indicate that SS cells are unable to activate an apoptosis pathway involving bcl-2 phosphorylation/inactivation and may provide a possible explanation for the limited effectiveness of conventional pharmacological treatments of this tumor type.
  • [MeSH-major] Biomarkers, Tumor / genetics. Genes, bcl-2. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Proteins c-bcl-2 / metabolism. Sarcoma / genetics. Synovial Membrane. Transcription, Genetic

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  • (PMID = 10879732.001).
  • [ISSN] 0023-6837
  • [Journal-full-title] Laboratory investigation; a journal of technical methods and pathology
  • [ISO-abbreviation] Lab. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / SYT-SSX fusion protein
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23. Harb WJ, Luna MA, Patel SR, Ballo MT, Roberts DB, Sturgis EM: Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck; 2007 Aug;29(8):731-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension.
  • BACKGROUND: The medical literature on synovial sarcoma (SS) of the head and neck region is limited.
  • Thus, we determined whether clinical characteristics and treatment were associated with recurrence and survival rates in patients with SS of the head and neck.
  • METHODS: We retrospectively identified patients with a pathologic diagnosis of SS of the head and neck at our institution (a large tertiary comprehensive cancer center) and compared recurrence and survival rates by clinical characteristics and treatment.
  • RESULTS: Forty patients with SS of the head and neck were identified from 1945 to 2004 (first case in 1968), representing <5% of all head and neck sarcomas seen at our institution during this time period.
  • Twenty-three patients (58%) had the monophasic histologic subtype, 15 (38%) biphasic, and 2 unspecified.
  • Patients treated with surgery and adjuvant radiotherapy had higher survival and lower recurrence rates than did those treated with surgery alone or a combination of surgery, radiotherapy, and chemotherapy.
  • CONCLUSIONS: SS of the head and neck is extremely rare, and our results should be viewed with caution given the relatively small group size and treatment over a 36-year period.
  • Treatment of SS of the head and neck should be directed toward complete surgical resection.
  • Given the known sensitivity of SS to contemporary chemotherapy, a multimodality approach should be considered in the perioperative setting, especially in high risk patients.
  • [MeSH-major] Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / surgery. Neoplasm Recurrence, Local / epidemiology. Sarcoma, Synovial / mortality. Sarcoma, Synovial / surgery
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Linear Models. Male. Medical Records. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Texas / epidemiology. Treatment Outcome

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  • (PMID = 17274049.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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24. Makhlouf HR, Ahrens W, Agarwal B, Dow N, Marshalleck JJ, Lee EL, Dotto JE, Hui P, Sobin LH, Oliveira A, Miettinen M: Synovial sarcoma of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 10 cases. Am J Surg Pathol; 2008 Feb;32(2):275-81
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial sarcoma of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 10 cases.
  • Only a few synovial sarcomas arising in the gastrointestinal tract have been reported, most of them are from the esophagus.
  • We report clinical, histopathologic, and immunohistochemical features of 10 gastric synovial sarcomas.
  • None of the patients had evidence of synovial sarcoma elsewhere.
  • Histologically, 9 tumors were monophasic one also having a poorly differentiated round cell component, and one was biphasic.
  • Two patients had received chemotherapy after surgery, but none had postoperative radiation.
  • Synovial sarcoma rarely occurs as a gastric primary tumor.
  • [MeSH-major] Sarcoma, Synovial / genetics. Sarcoma, Synovial / pathology. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / genetics. Combined Modality Therapy. DNA, Neoplasm. Female. Gastrectomy. Humans. Male. Middle Aged. Molecular Biology. Neoplasm Recurrence, Local. Oncogene Proteins, Fusion / analysis. Polymerase Chain Reaction

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  • (PMID = 18223331.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Oncogene Proteins, Fusion; 0 / SYT-SSX fusion protein
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